Stem Cells, Ageing and Cancer
Group leader
Our research group (SAC) aims at understanding the mechanisms of stem cell malignant transformation in the context the stem cell niche.
Long life expectancy is resulting in aged societies and a remarkable increase in age-related diseases, including cancer.
Stem cells self-renew and provide the source for replenishing mature cells in the organism throughout its life. These fascinating abilities ensure tissue regeneration, but must be fine-tuned regulated as their imbalance may contribute to both, ageing and cancer.
Stem cell behaviour results from integration of cell-autonomous and extracellular signals received from the stem cell niche.
Our research interest focuses on the processes that control stem cell behaviour. Taking the hematopoietic system as the primary model, our group aims at understanding the mechanisms of stem cell malignant transformation using an integrative perspective that considers cell-autonomous alterations in the stem cell and remodelling of the stem cell niche.
Research vision
Our goal is the identification of novel and efficient therapeutic targets of clinical interest that will improve survival rates and quality of life in patients.
Research Projects:
- Stem Cell Metabolic Dysfunction in Myeloid Leukaemia and its Therapeutic Targeting
- Exploring the transformation potential of haematopoietic stem cells under niche pressure, and its therapeutic targeting
- Imaging Ageing Endothelium at the nanoscale
Funding:
Our research is currently funded by NFR FRIPRO and Centres of Excellence scheme, and the European Union’s Horizon research and innovation programme MSCA Doctoral Networks.
