Publications 2023

Villatoro A, Cuminetti V, Bernal A, Torroja C, Cossío I, Benguría A, Ferré M, Konieczny J, Vázquez E, Rubio A, Utnes P, Tello A, You X, Fenton CG, Paulssen RH, Zhang J, Sánchez-Cabo F, Dopazo A, Vik A, Anderssen E, Hidalgo A, Arranz L (2023)
Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation
Nat Commun, 14 (1), 12
DOI 10.1038/s41467-022-35700-9, PubMed 36596811

Villatoro A, Cuminetti V, Bernal A, Torroja C, Cossío I, Benguría A, Ferré M, Konieczny J, Vázquez E, Rubio A, Utnes P, Tello A, You X, Fenton CG, Paulssen RH, Zhang J, Sánchez-Cabo F, Dopazo A, Vik A, Anderssen E, Hidalgo A, Arranz L (2023)
Author Correction: Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation
Nat Commun, 14 (1), 3874
DOI 10.1038/s41467-023-39601-3, PubMed 37391415

Publications 2022

Arranz L (2022)
The Hematology of Tomorrow Is Here-Preclinical Models Are Not: Cell Therapy for Hematological Malignancies
Cancers (Basel), 14 (3)
DOI 10.3390/cancers14030580, PubMed 35158848

Vilaplana-Lopera N, Cuminetti V, Almaghrabi R, Papatzikas G, Rout AK, Jeeves M, González E, Alyahyawi Y, Cunningham A, Erdem A, Schnütgen F, Raghavan M, Potluri S, Cazier JB, Schuringa JJ, Reed MAC, Arranz L, Günther UL, Garcia P (2022)
Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells
Elife, 11
DOI 10.7554/eLife.75908, PubMed 36052997

Publications 2021

Martínez de Toda I, Rattan SIS, De la Fuente M, Arranz L (2021)
Female Mice Reaching Exceptionally High Old Age Have Preserved 20S Proteasome Activities
Antioxidants (Basel), 10 (9)
DOI 10.3390/antiox10091397, PubMed 34573029

Maté I, Martínez de Toda I, Arranz L, Álvarez-Sala JL, De la Fuente M (2021)
Accelerated immunosenescence, oxidation and inflammation lead to a higher biological age in COPD patients
Exp Gerontol, 154, 111551
DOI 10.1016/j.exger.2021.111551, PubMed 34530106

Publications 2020

Villatoro A, Konieczny J, Cuminetti V, Arranz L (2020)
Leukemia Stem Cell Release From the Stem Cell Niche to Treat Acute Myeloid Leukemia
Front Cell Dev Biol, 8, 607
DOI 10.3389/fcell.2020.00607, PubMed 32754595

Publications 2019

Cuminetti V, Arranz L (2019)
Bone Marrow Adipocytes: The Enigmatic Components of the Hematopoietic Stem Cell Niche
J Clin Med, 8 (5)
DOI 10.3390/jcm8050707, PubMed 31109063

Publications 2018

Bernal A, Arranz L (2018)
Nestin-expressing progenitor cells: function, identity and therapeutic implications
Cell Mol Life Sci, 75 (12), 2177-2195
DOI 10.1007/s00018-018-2794-z, PubMed 29541793

Grimolizzi F, Arranz L (2018)
Multiple faces of succinate beyond metabolism in blood
Haematologica, 103 (10), 1586-1592
DOI 10.3324/haematol.2018.196097, PubMed 29954939

Konieczny J, Arranz L (2018)
Updates on Old and Weary Haematopoiesis
Int J Mol Sci, 19 (9)
DOI 10.3390/ijms19092567, PubMed 30158459

Thiyagarajan D, Pedersen HL, Seredkina N, Horvei KD, Arranz L, Sonneveld R, Nijenhuis T, van der Vlag J, Rekvig OP (2018)
IL-1β Promotes a New Function of DNase I as a Transcription Factor for the Fas Receptor Gene
Front Cell Dev Biol, 6, 7
DOI 10.3389/fcell.2018.00007, PubMed 29468159

Publications 2017

Arranz L, Arriero MDM, Villatoro A (2017)
Interleukin-1β as emerging therapeutic target in hematological malignancies and potentially in their complications
Blood Rev, 31 (5), 306-317
DOI 10.1016/j.blre.2017.05.001, PubMed 28495184

Publications 2014

Arranz L, Sánchez-Aguilera A, Martín-Pérez D, Isern J, Langa X, Tzankov A, Lundberg P, Muntión S, Tzeng YS, Lai DM, Schwaller J, Skoda RC, Méndez-Ferrer S (2014)
Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms
Nature, 512 (7512), 78-81
DOI 10.1038/nature13383, PubMed 25043017

Isern J, García-García A, Martín AM, Arranz L, Martín-Pérez D, Torroja C, Sánchez-Cabo F, Méndez-Ferrer S (2014)
The neural crest is a source of mesenchymal stem cells with specialized hematopoietic stem cell niche function
Elife, 3, e03696
DOI 10.7554/eLife.03696, PubMed 25255216

Sánchez-Aguilera A, Arranz L, Martín-Pérez D, García-García A, Stavropoulou V, Kubovcakova L, Isern J, Martín-Salamanca S, Langa X, Skoda RC, Schwaller J, Méndez-Ferrer S (2014)
Estrogen signaling selectively induces apoptosis of hematopoietic progenitors and myeloid neoplasms without harming steady-state hematopoiesis
Cell Stem Cell, 15 (6), 791-804
DOI 10.1016/j.stem.2014.11.002, PubMed 25479752

Publications 2013

Arranz L, Urbano-Ispizúa A, Méndez-Ferrer S (2013)
Mitochondria underlie different metabolism of hematopoietic stem and progenitor cells
Haematologica, 98 (7), 993-5
DOI 10.3324/haematol.2013.084293, PubMed 23813642

Isern J, Martín-Antonio B, Ghazanfari R, Martín AM, López JA, del Toro R, Sánchez-Aguilera A, Arranz L, Martín-Pérez D, Suárez-Lledó M, Marín P, Van Pel M, Fibbe WE, Vázquez J, Scheding S, Urbano-Ispizúa Á, Méndez-Ferrer S (2013)
Self-renewing human bone marrow mesenspheres promote hematopoietic stem cell expansion
Cell Rep, 3 (5), 1714-24
DOI 10.1016/j.celrep.2013.03.041, PubMed 23623496

Publications 2012

Arranz L, Naudí A, De la Fuente M, Pamplona R (2012)
Exceptionally old mice are highly resistant to lipoxidation-derived molecular damage
Age (Dordr), 35 (3), 621-35
DOI 10.1007/s11357-012-9391-0, PubMed 22367548

Publications 2011

Arranz L, De Castro NM, Baeza I, Giménez-Llort L, De la Fuente M (2011)
Effect of environmental enrichment on the immunoendocrine aging of male and female triple-transgenic 3xTg-AD mice for Alzheimer's disease
J Alzheimers Dis, 25 (4), 727-37
DOI 10.3233/JAD-2011-110236, PubMed 21593564

Baeza I, De Castro NM, Arranz L, Fdez-Tresguerres J, De la Fuente M (2011)
Ovariectomy causes immunosenescence and oxi-inflamm-ageing in peritoneal leukocytes of aged female mice similar to that in aged males
Biogerontology, 12 (3), 227-38
DOI 10.1007/s10522-010-9317-0, PubMed 21197577

Publications 2010

Arranz L, Caamaño JH, Lord JM, De la Fuente M (2010)
Preserved immune functions and controlled leukocyte oxidative stress in naturally long-lived mice: possible role of nuclear factor kappa B
J Gerontol A Biol Sci Med Sci, 65 (9), 941-50
DOI 10.1093/gerona/glq101, PubMed 20558495

Arranz L, De Castro NM, Baeza I, De la Fuente M (2010)
Differential expression of Toll-like receptor 2 and 4 on peritoneal leukocyte populations from long-lived and non-selected old female mice
Biogerontology, 11 (4), 475-82
DOI 10.1007/s10522-010-9270-y, PubMed 20306223

Arranz L, De Castro NM, Baeza I, Maté I, Viveros MP, De la Fuente M (2010)
Environmental enrichment improves age-related immune system impairment: long-term exposure since adulthood increases life span in mice
Rejuvenation Res, 13 (4), 415-28
DOI 10.1089/rej.2009.0989, PubMed 20707722

Arranz L, Lord JM, De la Fuente M (2010)
Preserved ex vivo inflammatory status and cytokine responses in naturally long-lived mice
Age (Dordr), 32 (4), 451-66
DOI 10.1007/s11357-010-9151-y, PubMed 20508994

Baeza I, De Castro NM, Arranz L, De la Fuente M (2010)
Soybean and green tea polyphenols improve immune function and redox status in very old ovariectomized mice
Rejuvenation Res, 13 (6), 665-74
DOI 10.1089/rej.2010.1049, PubMed 20818935

Publications 2009

Arranz L, de Vicente A, Muñoz M, De la Fuente M (2009)
Impaired immune function in a homeless population with stress-related disorders
Neuroimmunomodulation, 16 (4), 251-60
DOI 10.1159/000212386, PubMed 19365149

Arranz L, Giménez-Llort L, De Castro NM, Baeza I, De la Fuente M (2009)
[Social isolation during old age worsens cognitive, behavioral and immune impairment]
Rev Esp Geriatr Gerontol, 44 (3), 137-42
DOI 10.1016/j.regg.2008.12.001, PubMed 19427064

Publications 2008

Arranz L, Fernández C, Rodríguez A, Ribera JM, De la Fuente M (2008)
The glutathione precursor N-acetylcysteine improves immune function in postmenopausal women
Free Radic Biol Med, 45 (9), 1252-62
DOI 10.1016/j.freeradbiomed.2008.07.014, PubMed 18694818

Giménez-Llort L, Arranz L, Maté I, De la Fuente M (2008)
Gender-specific neuroimmunoendocrine aging in a triple-transgenic 3xTg-AD mouse model for Alzheimer's disease and its relation with longevity
Neuroimmunomodulation, 15 (4-6), 331-43
DOI 10.1159/000156475, PubMed 19047809

Publications 2007

Arranz L, Guayerbas N, De la Fuente M (2007)
Impairment of several immune functions in anxious women
J Psychosom Res, 62 (1), 1-8
DOI 10.1016/j.jpsychores.2006.07.030, PubMed 17188114

Arranz L, Guayerbas N, Siboni L, De la Fuente M (2007)
Effect of acupuncture treatment on the immune function impairment found in anxious women
Am J Chin Med, 35 (1), 35-51
DOI 10.1142/S0192415X07004606, PubMed 17265549

Baeza I, de Castro NM, Alvarado C, Alvarez P, Arranz L, Bayón J, de la Fuente M (2007)
Improvement of immune cell functions in aged mice treated for five weeks with soybean isoflavones
Ann N Y Acad Sci, 1100, 497-504
DOI 10.1196/annals.1395.054, PubMed 17460214

Llorente R, Arranz L, Marco EM, Moreno E, Puerto M, Guaza C, De la Fuente M, Viveros MP (2007)
Early maternal deprivation and neonatal single administration with a cannabinoid agonist induce long-term sex-dependent psychoimmunoendocrine effects in adolescent rats
Psychoneuroendocrinology, 32 (6), 636-50
DOI 10.1016/j.psyneuen.2007.04.002, PubMed 17553622

Viveros MP, Arranz L, Hernanz A, Miquel J, De la Fuente M (2007)
A model of premature aging in mice based on altered stress-related behavioral response and immunosenescence
Neuroimmunomodulation, 14 (3-4), 157-62
DOI 10.1159/000110640, PubMed 18073508

Zambrana C, Marco EM, Arranz L, de Castro NM, Viveros MP, de la Fuente M (2007)
Influence of aging and enriched environment on motor activity and emotional responses in mice
Ann N Y Acad Sci, 1100, 543-52
DOI 10.1196/annals.1395.060, PubMed 17460220

Publications 2005

Pérez-Alvarez L, Baeza I, Arranz L, Marco EM, Borcel E, Guaza C, Viveros MP, De la Fuente M (2005)
Behavioral, endocrine and immunological characteristics of a murine model of premature aging
Dev Comp Immunol, 29 (11), 965-76
DOI 10.1016/j.dci.2005.02.008, PubMed 15935474