Published papers 2009-2023

Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3. https://pubmed.ncbi.nlm.nih.gov/37798283/
Heggelund JE, Das S, Stamnaes J, Iversen R, Sollid LM
Nat Commun 2023 Oct 05;14(1):6216.

Functional Diversity of Homologous Oxidoreductases-Tuning of Substrate Specificity by a FAD-Stacking Residue for Iron Acquisition and Flavodoxin Reduction. https://pubmed.ncbi.nlm.nih.gov/37371954/
Hammerstad M, Rugtveit AK, Dahlen S, Andersen HK, Hersleth HP
Antioxidants (Basel) 2023 Jun 06;12(6).

A homozygous POLR1A variant causes leukodystrophy and affects protein homeostasis. https://pubmed.ncbi.nlm.nih.gov/36917474/
Misceo D, Lirussi L, Strømme P, Sumathipala D, Guerin A, Wolf NI, Server A, Stensland M, Dalhus B, Tolun A, Kroes HY, Nyman TA, Nilsen HL, Frengen E
Brain 2023 Aug 01;146(8):3513.

The role of PGM1isoform 2 in PGM1-CDG: One step closer to genotype-phenotype correlation? https://pubmed.ncbi.nlm.nih.gov/36843136/
Radenkovic S, Laerdahl JK, Backe PH, Morava E
J Inherit Metab Dis 2023 Mar;46(2):159.

BCKDK deficiency: a treatable neurodevelopmental disease amenable to newborn screening. https://pubmed.ncbi.nlm.nih.gov/36729635/
Tangeraas T, Constante JR, Backe PH, Oyarzábal A, Neugebauer J, Weinhold N, Boemer F, Debray FG, Ozturk-Hism B, Evren G, Tuba EF, Ummuhan O, Footitt E, Davison J, Martinez C, Bueno C, Machado I, Rodríguez-Pombo P, Al-Sannaa N, De Los Santos M, López JM, Ozturkmen-Akay H, Karaca M, Tekin M, Pajares S, Ormazabal A, Stoway SD, Artuch R, Dixon M, Mørkrid L, García-Cazorla A
Brain 2023 Jul 03;146(7):3003.

Affinity maturation of TCR-like antibodies using phage display guided by structural modeling. https://pubmed.ncbi.nlm.nih.gov/35871543/
Frick R, Høydahl LS, Hodnebrug I, Vik ES, Dalhus B, Sollid LM, Gray JJ, Sandlie I, Løset GÅ
Protein Eng Des Sel 2022 Feb 17;35.

Studies on Protein-RNA:DNA Hybrid Interactions by Microscale Thermophoresis (MST). https://pubmed.ncbi.nlm.nih.gov/35704195/
Li M, Klungland A, Dalhus B
Methods Mol Biol 2022;2528:239-251.

Novel mutations in the HADHB gene causing a mild phenotype of mitochondrial trifunctional protein (MTP) deficiency. https://pubmed.ncbi.nlm.nih.gov/35433169/
Ørstavik K, Arntzen KA, Mathisen P, Backe PH, Tangeraas T, Rasmussen M, Kristensen E, Van Ghelue M, Jonsrud C, Bliksrud YT
JIMD Rep 2022 May;63(3):193.

ZBTB11 dysfunction: spectrum of brain abnormalities, biochemical signature and cellular consequences. https://pubmed.ncbi.nlm.nih.gov/35104841/
Sumathipala D, Strømme P, Fattahi Z, Lüders T, Sheng Y, Kahrizi K, Einarsen IH, Sloan JL, Najmabadi H, van den Heuvel L, Wevers RA, Guerrero-Castillo S, Mørkrid L, Valayannopoulos V, Backe PH, Venditti CP, van Karnebeek CD, Nilsen H, Frengen E, Misceo D
Brain 2022 Jul 29;145(7):2602.

A Silicone Oil-Free Syringe Tailored for Intravitreal Injection of Biologics. https://pubmed.ncbi.nlm.nih.gov/38983507/
Gjølberg TT, Lode HE, Melo GB, Mester S, Probst C, Sivertsen MS, Jørstad ØK, Andersen JT, Moe MC
Front. Ophthalmol., 2022 May 02, Vol 2, 882013.

Immobilization of FeFe-hydrogenase on black TiO2 nanotubes as biocathodes for the hydrogen evolution reaction. https://www.sciencedirect.com/science/article/pii/S1388248122000236
Liu X, Risbakk S., Carvalho PA, Yang M, Backe PH, Bjørås M, Norby T Chatzitakis A
Electrochemistry Communications, 2022, Feb, Vol 135, 107221.

AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR. https://pubmed.ncbi.nlm.nih.gov/34814703/
Carlson CR, Aronsen Jm, Bergan-Dahl A, Moutty MC, Lunde M, Lunde PK, Jarstadmarken H, Wanichawan P, Pereira L, Kolstad TRS, Dalhus B, Subramanian H, Hille S, Christensen G, Müller OJ, Nikolaev V, Bers DM, Sjaastad I, Shen X, Louch WE, Klussmann E, Sejersted OM
Circ Res 2022 Jan 07;130(1):27.

Synthesis and Evaluation of Fused Pyrimidines as E. coli Thymidylate Monophosphate Kinase Inhibitors. https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202103796
Blindheim F, Malme AT, Dalhus B, Sundby E, Hoff BH
ChemistrySelect, 2021, Vol 6, 45, 12852-12857.

In situ cofactor regeneration enables selective CO2 reduction in a stable and efficient enzymatic photoelectrochemical cell. https://www.sciencedirect.com/science/article/pii/S0926337321004756
Xu KQ, Chatzitakis A, Backe PH, Ruan QS, Tang JW, Rise F, Bjoras M, Norby T
Appl. Catal. B-Environ., 2021, 296, 120349.

Thioredoxin reductase from Bacillus cereus exhibits distinct reduction and NADPH-binding properties. https://pubmed.ncbi.nlm.nih.gov/34492167/
Shoor M, Gudim I, Hersleth HP, Hammerstad M
FEBS Open Bio 2021 11;11(11):3019-3031.

Non-flipping DNA glycosylase AlkD scans DNA without formation of a stable interrogation complex. https://pubmed.ncbi.nlm.nih.gov/34267321/
Ahmadi A, Till K, Backe PH, Blicher P, Diekmann R, Schüttpelz M, Glette K, Tørresen J, Bjørås M, Rowe AD, Dalhus B
Commun Biol 2021 07 15;4(1):876.

A novel somatic mutation in GNB2 provides new insights to the pathogenesis of Sturge-Weber syndrome. https://pubmed.ncbi.nlm.nih.gov/34124757/
Fjær R, Marciniak K, Sundnes O, Hjorthaug H, Sheng Y, Hammarström C, Sitek JC, Vigeland MD, Backe PH, Øye AM, Fosse JH, Stav-Noraas TE, Uchiyama Y, Matsumoto N, Comi A, Pevsner J, Haraldsen G, Selmer KK
Hum Mol Genet 2021 10 13;30(21):1919-1931.

CdgL is a degenerate nucleotide cyclase domain protein affecting flagellin synthesis and motility in Bacillus thuringiensis. https://pubmed.ncbi.nlm.nih.gov/34082027/
Smith V, Nilssen IKB, Hegna IK, Dalhus B, Fagerlund A, Økstad OA
Res Microbiol 2021 Jun-Aug;172(4-5):103850.

Overview of structurally homologous flavoprotein oxidoreductases containing the low Mr thioredoxin reductase-like fold - A functionally diverse group https://pubmed.ncbi.nlm.nih.gov/33684359/
Hammerstad M, Hersleth HP
Arch Biochem Biophys 2021 05 15;702():108826.

High performance and toxicity assessment of Ta3N5 nanotubes for photoelectrochemical water splitting. https://www.sciencedirect.com/science/article/pii/S0920586119306947
Xu KQ, Chatzitakis A, Risbakk S, Yang MY, Backe PH, Grandcolas M, Bjoras M, Norby T
Catal. Today, 2021, 361, 57-62.

Molecular Characterization of Two Homozygous Factor VII Variants Associated with Intracranial Bleeding. https://pubmed.ncbi.nlm.nih.gov/33742435/
Andersen E, Chollet ME, Sletten M, Stavik B, Skarpen E, Backe PH, Thiede B, Glosli H, Henriksson CE, Iversen N
Thromb Haemost 2021 Dec;121(12):1588-1598.

The Crystal Structures of Bacillithiol Disulfide Reductase Bdr (YpdA) Provide Structural and Functional Insight into a New Type of FAD-Containing NADPH-Dependent Oxidoreductase. https://pubmed.ncbi.nlm.nih.gov/33326741/
Hammerstad M, Gudim I, Hersleth HP
Biochemistry 2020 Dec 29;59(51):4793-4798.

An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics. https://pubmed.ncbi.nlm.nih.gov/33055243/
Bern M, Nilsen J, Ferrarese M, Sand KMK, Gjølberg TT, Lode HE, Davidson RJ, Camire RM, Bækkevold ES, Foss S, Grevys A, Dalhus B, Wilson J, Høydahl LS, Christianson GJ, Roopenian DC, Schlothauer T, Michaelsen TE, Moe MC, Lombardi S, Pinotti M, Sandlie I, Branchini A, Andersen JT
Sci Transl Med 2020 10 14;12(565).

Peptides containing the PCNA interacting motif APIM bind to the β-clamp and inhibit bacterial growth and mutagenesis. https://pubmed.ncbi.nlm.nih.gov/32347931/
Nedal A, Ræder SB, Dalhus B, Helgesen E, Forstrøm RJ, Lindland K, Sumabe BK, Martinsen JH, Kragelund BB, Skarstad K, Bjørås M, Otterlei M
Nucleic Acids Res 2020 06 04;48(10):5540-5554.

An intact C-terminal end of albumin is required for its long half-life in humans. https://pubmed.ncbi.nlm.nih.gov/32313072/
Nilsen J, Trabjerg E, Grevys A, Azevedo C, Brennan SO, Stensland M, Wilson J, Sand KMK, Bern M, Dalhus B, Roopenian DC, Sandlie I, Rand KD, Andersen JT
Commun Biol 2020 04 20;3(1):181.

Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the α-D-phosphohexomutase superfamily. https://pubmed.ncbi.nlm.nih.gov/32221390/
Backe PH, Laerdahl JK, Kittelsen LS, Dalhus B, Mørkrid L, Bjørås M
Sci Rep 2020 03 27;10(1):5656.

N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells. https://pubmed.ncbi.nlm.nih.gov/31844323/
Abakir A, Giles TC, Cristini A, Foster JM, Dai N, Starczak M, Rubio-Roldan A, Li M, Eleftheriou M, Crutchley J, Flatt L, Young L, Gaffney DJ, Denning C, Dalhus B, Emes RD, Gackowski D, Corrêa IR, Garcia-Perez JL, Klungland A, Gromak N, Ruzov A
Nat Genet 2020 01;52(1):48-55.

A new method for pharmaceutical compounding and storage of anti-VEGF biologics for intravitreal use in silicone oil-free prefilled plastic syringes. https://pubmed.ncbi.nlm.nih.gov/31792234/
Lode HE, Gjølberg TT, Foss S, Sivertsen MS, Brustugun J, Andersson Y, Jørstad ØK, Moe MC, Andersen JT
Sci Rep 2019 Dec 02;9(1):18021.

Additive manufacturing of laminar flow cells for single-molecule experiments. https://pubmed.ncbi.nlm.nih.gov/31727950/
Ahmadi A, Till K, Hafting Y, Schüttpelz M, Bjørås M, Glette K, Tørresen J, Rowe AD, Dalhus B
Sci Rep 2019 Nov 14;9(1):16784.

The SH3 domains of the protein kinases ITK and LCK compete for adjacent sites on T cell-specific adapter protein. https://pubmed.ncbi.nlm.nih.gov/31484725/
Andersen TCB, Kristiansen PE, Huszenicza Z, Johansson MU, Gopalakrishnan RP, Kjelstrup H, Boyken S, Sundvold-Gjerstad V, Granum S, Sørli M, Backe PH, Fulton DB, Karlsson BG, Andreotti AH, Spurkland A
J Biol Chem 2019 Oct 18;294(42):15480-15494.

Inhibiting nucleolin reduces inflammation induced by mitochondrial DNA in cardiomyocytes exposed to hypoxia and reoxygenation. https://pubmed.ncbi.nlm.nih.gov/31412132/
Mariero LH, Torp MK, Heiestad CM, Baysa A, Li Y, Valen G, Vaage J, Stensløkken KO
Br J Pharmacol 2019 Nov;176(22):4360-4372.

Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca2+-Dependent Arrhythmia. https://pubmed.ncbi.nlm.nih.gov/30943765/
Ottesen AH, Carlson CR, Eken OS, Sadredini M, Myhre PL, Shen X, Dalhus B, Laver DR, Lunde PK, Kurola J, Lunde M, Hoff JE, Godang K, Sjaastad I, Pettilä V, Stridsberg M, Edwards AG, Lunde IG, Omland T, Stokke MK, Christensen G, Røsjø H
Circ Arrhythm Electrophysiol 2019 04;12(4):e007045.

Biallelic POLR3A variants confirmed as a frequent cause of hereditary ataxia and spastic paraparesis. https://pubmed.ncbi.nlm.nih.gov/30847471/
Rydning SL, Koht J, Sheng Y, Sowa P, Hjorthaug HS, Wedding IM, Erichsen AK, Hovden IA, Backe PH, Tallaksen CME, Vigeland MD, Selmer KK
Brain 2019 04 01;142(4):e12.

Structural and Thermodynamic Signatures of Ligand Binding to the Enigmatic Chitinase D of Serratia proteamaculans. https://pubmed.ncbi.nlm.nih.gov/30789732/
Madhuprakash J, Dalhus B, Vaaje-Kolstad G, Sakuda S, Podile AR, Eijsink VGH, Sørlie M
J Phys Chem B 2019 Mar 14;123(10):2270-2279.

Specificity of Escherichia coli Heat-Labile Enterotoxin Investigated by Single-Site Mutagenesis and Crystallography https://pubmed.ncbi.nlm.nih.gov/30736336/
Heggelund JE, Heim JB, Bajc G, Hodnik V, Anderluh G, Krengel U
Int J Mol Sci 2019 Feb 06;20(3).

Breaking the speed limit with multimode fast scanning of DNA by Endonuclease V. https://pubmed.ncbi.nlm.nih.gov/30568191/
Ahmadi A, Rosnes I, Blicher P, Diekmann R, Schüttpelz M, Glette K, Tørresen J, Bjørås M, Dalhus B, Rowe AD
Nat Commun 2018 12 19;9(1):5381.

Human and mouse albumin bind their respective neonatal Fc receptors differently. https://pubmed.ncbi.nlm.nih.gov/30279529/
Nilsen J, Bern M, Sand KMK, Grevys A, Dalhus B, Sandlie I, Andersen JT
Sci Rep 2018 Oct 02;8(1):14648.

The Characterization of Different Flavodoxin Reductase-Flavodoxin (FNR-Fld) Interactions Reveals an Efficient FNR-Fld Redox Pair and Identifies a Novel FNR Subclass. https://pubmed.ncbi.nlm.nih.gov/30142264/
Gudim I, Hammerstad M, Lofstad M, Hersleth HP
Biochemistry 2018 Sep 18;57(37):5427-5436.

Hb Oslo [β42(CD1)Phe→Ile; HBB: c.127T>A]: A Novel Unstable Hemoglobin Variant Found in a Norwegian Patient. https://pubmed.ncbi.nlm.nih.gov/30032685/
Grimholt RM, Vestli A, Urdal P, Bechensteen AG, Fjeld B, Dalhus B, Klingenberg O
Hemoglobin 2018 Mar;42(2):78-83.

Key Residues Affecting Transglycosylation Activity in Family 18 Chitinases: Insights into Donor and Acceptor Subsites. https://pubmed.ncbi.nlm.nih.gov/29939724/
Madhuprakash J, Dalhus B, Rani TS, Podile AR, Eijsink VGH, Sørlie M
Biochemistry 2018 Jul 24;57(29):4325-4337.

Publisher Correction: Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability. https://pubmed.ncbi.nlm.nih.gov/29651030/
Bosshard M, Aprigliano R, Gattiker C, Palibrk V, Markkanen E, Hoff Backe P, Pellegrino S, Raymond FL, Froyen G, Altmeyer M, Bjørås M, Dianov GL, van Loon B
Sci Rep 2018 Apr 12;8(1):6010.

Biallelic variants in KIF14 cause intellectual disability with microcephaly. https://pubmed.ncbi.nlm.nih.gov/29343805/
Makrythanasis P, Maroofian R, Stray-Pedersen A, Musaev D, Zaki MS, Mahmoud IG, Selim L, Elbadawy A, Jhangiani SN, Coban Akdemir ZH, Gambin T, Sorte HS, Heiberg A, McEvoy-Venneri J, James KN, Stanley V, Belandres D, Guipponi M, Santoni FA, Ahangari N, Tara F, Doosti M, Iwaszkiewicz J, Zoete V, Backe PH, Hamamy H, Gleeson JG, Lupski JR, Karimiani EG, Antonarakis SE
Eur J Hum Genet 2018 03;26(3):330-339.

Structural determinants of bacterial lytic polysaccharide monooxygenase functionality. https://pubmed.ncbi.nlm.nih.gov/29222333/
Forsberg Z, Bissaro B, Gullesen J, Dalhus B, Vaaje-Kolstad G, Eijsink VGH
J Biol Chem 2018 01 26;293(4):1397-1412.

Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability. https://pubmed.ncbi.nlm.nih.gov/29118367/
Bosshard M, Aprigliano R, Gattiker C, Palibrk V, Markkanen E, Hoff Backe P, Pellegrino S, Raymond FL, Froyen G, Altmeyer M, Bjørås M, Dianov GL, van Loon B
Sci Rep 2017 Nov 08;7(1):15050.

Stereotyped antibody responses target posttranslationally modified gluten in celiac disease. https://pubmed.ncbi.nlm.nih.gov/28878138/
Snir O, Chen X, Gidoni M, du Pré MF, Zhao Y, Steinsbø Ø, Lundin KE, Yaari G, Sollid LM
JCI Insight 2017 Sep 07;2(17).

A TCRα framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions. https://pubmed.ncbi.nlm.nih.gov/28878121/
Gunnarsen KS, Høydahl LS, Risnes LF, Dahal-Koirala S, Neumann RS, Bergseng E, Frigstad T, Frick R, du Pré MF, Dalhus B, Lundin KE, Qiao SW, Sollid LM, Sandlie I, Løset GÅ
JCI Insight 2017 Sep 07;2(17).

Visualization of PML nuclear import complexes reveals FG-repeat nucleoporins at cargo retrieval sites. https://pubmed.ncbi.nlm.nih.gov/28402725/
Lång A, Eriksson J, Schink KO, Lång E, Blicher P, Polec A, Brech A, Dalhus B, Bøe SO
Nucleus 2017 Jul 04;8(4):404-420.

Measurement of FNR-NrdI Interaction by Microscale Thermophoresis (MST). https://pubmed.ncbi.nlm.nih.gov/34541225/
Gudim I, Lofstad M, Hammerstad M, Hersleth HP
Bio-protocol, 2017, 7(8), s e2223.

Novel UCHL1 mutations reveal new insights into ubiquitin processing. https://pubmed.ncbi.nlm.nih.gov/28007905/
Rydning SL, Backe PH, Sousa MML, Iqbal Z, Øye AM, Sheng Y, Yang M, Lin X, Slupphaug G, Nordenmark TH, Vigeland MD, Bjørås M, Tallaksen CM, Selmer KK
Hum Mol Genet 2017 03 15;26(6):1031-1040.

A potential founder variant in CARMIL2/RLTPR in three Norwegian families with warts, molluscum contagiosum, and T-cell dysfunction. https://pubmed.ncbi.nlm.nih.gov/27896283/
Sorte HS, Osnes LT, Fevang B, Aukrust P, Erichsen HC, Backe PH, Abrahamsen TG, Kittang OB, Øverland T, Jhangiani SN, Muzny DM, Vigeland MD, Samarakoon P, Gambin T, Akdemir ZH, Gibbs RA, Rødningen OK, Lyle R, Lupski JR, Stray-Pedersen A
Mol Genet Genomic Med 2016 Nov;4(6):604-616.

Characterization of the Neisseria meningitidis Helicase RecG. https://pubmed.ncbi.nlm.nih.gov/27736945/
Beyene GT, Balasingham SV, Frye SA, Namouchi A, Homberset H, Kalayou S, Riaz T, Tønjum T
PLoS One 2016;11(10):e0164588.

Activation of the Class Ib Ribonucleotide Reductase by a Flavodoxin Reductase in Bacillus cereus
Lofstad M, Gudim I, Hammerstad M, Røhr ÅK, Hersleth HP.
Biochemistry. 2016 Sep 13;55(36):4998-5001.

Regulation of Human Endonuclease V Activity and Relocalization to Cytoplasmic Stress Granules
Nawaz MS, Vik ES, Berges N, Fladeby C, Bjørås M, Dalhus B, Alseth I.
J Biol Chem. 2016 Aug 29. pii: jbc.M116.730911. [Epub ahead of print]

Axitinib blocks Wnt/β-catenin signaling and directs asymmetric cell division in cancer
Qu Y, Gharbi N, Yuan X, Olsen JR, Blicher P, Dalhus B, Brokstad KA, Lin B, Øyan AM, Zhang W, Kalland KH, Ke X.
Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9339-44.

Crystal structure and MD simulation of mouse EndoV reveal wedge motif plasticity in this inosine-specific endonuclease
Nawaz MS, Vik ES, Ronander ME, Solvoll AM, Blicher P, Bjørås M, Alseth I, Dalhus B.
Sci Rep. 2016 Apr 25;6:24979.

TRIM21 Immune Signaling Is More Sensitive to Antibody Affinity Than Its Neutralization Activity
Foss S, Watkinson RE, Grevys A, McAdam MB, Bern M, Høydahl LS, Dalhus B, Michaelsen TE, Sandlie I, James LC, Andersen JT.
J Immunol. 2016 Apr 15;196(8):3452-9. 

Structural and Functional Analysis of a Lytic Polysaccharide Monooxygenase Important for Efficient Utilization of Chitin in Cellvibrio japonicus 
Forsberg Z, Nelson CE, Dalhus B, Mekasha S, Loose JS, Crouch LI, Røhr ÅK, Gardner JG, Eijsink VG, Vaaje-Kolstad G.
J Biol Chem. 2016 Apr 1;291(14):7300-12.

Structural and functional characterization of a small chitin-active lytic polysaccharide monooxygenase domain of a multi-modular chitinase from Jonesia denitrificans
Mekasha S, Forsberg Z, Dalhus B, Bacik JP, Choudhary S, Schmidt-Dannert C, Vaaje-Kolstad G, Eijsink VG.
FEBS Lett. 2016 Jan;590(1):34-42.

Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger 1 Regulates Its Activity by Dephosphorylating Serine 68-phosphorylated Phospholemman 
Hafver TL, Hodne K, Wanichawan P, Aronsen JM, Dalhus B, Lunde PK, Lunde M, Martinsen M, Enger UH, Fuller W, Sjaastad I, Louch WE, Sejersted OM, Carlson CR.
J Biol Chem. 2016 Feb 26;291(9):4561-79. 

Mutation analysis in Norwegian families with hereditary hemorrhagic telangiectasia: founder mutations in ACVRL1
Heimdal K, Dalhus B, Rødningen OK, Kroken M, Eiklid K, Dheyauldeen S, Røysland T, Andersen R, Kulseth MA.
Clin Genet. 2016 Feb;89(2):182-6. 

Susceptibility to infections, without concomitant hyper-IgE, reported in 1976, is caused by hypomorphic mutation in the phosphoglucomutase 3 (PGM3) gene.
Lundin KE, Hamasy A, Backe PH, Moens LN, Falk-Sörqvist E, Elgstøen KB, Mørkrid L, Bjørås M, Granert C, Norlin AC, Nilsson M, Christensson B, Stenmark S, Smith CI
Clin Immunol 2015 Dec;161(2):366-72. Epub 2015 okt 19

TRIM21: a cytosolic Fc receptor with broad antibody isotype specificity.
Foss S, Watkinson R, Sandlie I, James LC, Andersen JT
Immunol Rev 2015 Nov;268(1):328-39.

Generalized epilepsy in a family with basal ganglia calcifications and mutations in SLC20A2 and CHRNB2.
Fjaer R, Brodtkorb E, Øye AM, Sheng Y, Vigeland MD, Kvistad KA, Backe PH, Selmer KK
Eur J Med Genet 2015 Nov;58(11):624-8. Epub 2015 okt 19

The Inner Membrane Protein PilG Interacts with DNA and the Secretin PilQ in Transformation.
Frye SA, Lång E, Beyene GT, Balasingham SV, Homberset H, Rowe AD, Ambur OH, Tønjum T
PLoS One 2015;10(8):e0134954. Epub 2015 aug 6

Structural Basis for Antigen Recognition by Transglutaminase 2-specific Autoantibodies in Celiac Disease.
Chen X, Hnida K, Graewert MA, Andersen JT, Iversen R, Tuukkanen A, Svergun D, Sollid LM
J Biol Chem 2015 Aug 28;290(35):21365-75. Epub 2015 jul 9

The role of albumin receptors in regulation of albumin homeostasis: Implications for drug delivery.
Bern M, Sand KM, Nilsen J, Sandlie I, Andersen JT
J Control Release 2015 Aug 10;211():144-62. Epub 2015 jun 6

Structural Features of a Bacteroidetes-Affiliated Cellulase Linked with a Polysaccharide Utilization Locus.
Naas AE, MacKenzie AK, Dalhus B, Eijsink VG, Pope PB
Sci Rep 2015;5():11666. Epub 2015 jul 2

Secretoneurin is a novel prognostic cardiovascular biomarker associated with cardiomyocyte calcium handling.
Ottesen AH, Louch WE, Carlson CR, Landsverk OJ, Kurola J, Johansen RF, Moe MK, Aronsen Jm, Høiseth AD, Jarstadmarken H, Nygård S, Bjørås M, Sjaastad I, Pettilä V, Stridsberg M, Omland T, Christensen G, Røsjø H
J Am Coll Cardiol 2015 Feb 3;65(4):339-51.

Molecular analysis of maple syrup urine disease in Jordanian families.
Jaradat SA, Al-Qa'qa' K, Amayreh W, Backe PH, Al-Hawamdeh A, Karam M, Alzoubi B, Deebajah H, Rababah BA
Meta Gene, 2015, doi:10.1016/j.mgene.2015.10.002

Publications 2014  

Interaction with both domain I and III of albumin is required for optimal pH-dependent binding to the neonatal Fc receptor (FcRn).
Sand KM, Bern M, Nilsen J, Dalhus B, Gunnarsen KS, Cameron J, Grevys A, Bunting K, Sandlie I, Andersen JT. 
J Biol Chem. 2014 Dec 12;289(50):34583-94.

Molecular basis of calpain cleavage and inactivation of the sodium-calcium exchanger 1 in heart failure.
Wanichawan P, Hafver TL, Hodne K, Aronsen JM, Lunde IG, Dalhus B, Lunde M, Kvaløy H, Louch WE, Tønnessen T, Sjaastad I, Sejersted OM, Carlson CR.
J Biol Chem. 2014 Dec 5;289(49):33984-98.

Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies.
Sand KM, Dalhus B, Christianson GJ, Bern M, Foss S, Cameron J, Sleep D, Bjørås M, Roopenian DC, Sandlie I, Andersen JT.
J Biol Chem. 2014 Jun 13;289(24):17228-39.

Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding.
Andersen JT, Dalhus B, Viuff D, Ravn BT, Gunnarsen KS, Plumridge A, Bunting K, Antunes F, Williamson R, Athwal S, Allan E, Evans L, Bjørås M, Kjærulff S, Sleep D, Sandlie I, Cameron J.
J Biol Chem. 2014 May 9;289(19):13492-502. 

A dominant STIM1 mutation causes Stormorken syndrome.
Misceo D, Holmgren A, Louch WE, Holme PA, Mizobuchi M, Morales RJ, De Paula AM, Stray-Pedersen A, Lyle R, Dalhus B, Christensen G, Stormorken H, Tjønnfjord GE, Frengen E.
Hum Mutat. 2014 May;35(5):556-64.

Publications 2013

Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin.
Krokeide SZ, Laerdahl JK, Salah M, Luna L, Cederkvist FH, Fleming AM, Burrows CJ, Dalhus B, Bjørås M.
DNA Repair (Amst). 2013 2013 Dec;12(12):1159-64.

Genotype-phenotype analysis of S326C OGG1 polymorphism: a risk factor for oxidative pathologies.
Simonelli V, Camerini S, Mazzei F, Van Loon B, Allione A, D'Errico M, Barone F, Minoprio A, Ricceri F, Guarrera S, Russo A, Dalhus B, Crescenzi M, Hubscher U, Bjoras M, Matullo G, Dogliotti E.
Free Radic Biol Med. 2013 Oct;63:401-9.

A new family of proteins related to the HEAT-like repeat DNA glycosylases with affinity for branched DNA structures.
Backe PH, Simm R, Laerdahl JK, Dalhus B, Fagerlund A, Okstad OA, Rognes T, Alseth I, Kolstø AB, Bjørås M.
J Struct Biol. 2013 Jul;183(1):66-75.

Novel Deletion Mutation Identified in a Patient with Late-Onset Combined Methylmalonic Acidemia and Homocystinuria, cblC Type.
Backe PH, Ytre-Arne M, Røhr AK, Brodtkorb E, Fowler B, Rootwelt H, Bjørås M, Mørkrid L. JIMD Rep. 2013 Apr 12. [Epub ahead of print] PMID: 23580368

Evolutionary paths of the cAMP-dependent protein kinase (PKA) catalytic subunits.
Søberg K, Jahnsen T, Rognes T, Skålhegg BS, Laerdahl JK.
PLoS One. 2013 Apr 12;8(4):e60935. 

Single transmembrane peptide DinQ modulates membrane-dependent activities.
Weel-Sneve R, Kristiansen KI, Odsbu I, Dalhus B, Booth J, Rognes T, Skarstad K, Bjørås M.
PLoS Genet. 2013;9(2):e1003260.

Structural basis of DNA loop recognition by endonuclease V.
Rosnes I, Rowe AD, Vik ES, Forstrøm RJ, Alseth I, Bjørås M, Dalhus B.
Structure. 2013 Feb 5;21(2):257-65. 

The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control.
Jobert L, Skjeldam HK, Dalhus B, Galashevskaya A, Vågbø CB, Bjørås M, Nilsen H.
Mol Cell. 2013 Jan 24;49(2):339-45. 

Sculpting of DNA at abasic sites by DNA glycosylase homolog mag2.
Dalhus B, Nilsen L, Korvald H, Huffman J, Forstrøm RJ, McMurray CT, Alseth I, Tainer JA, Bjørås M.
Structure. 2013 Jan 8;21(1):154-66.  

Publications 2012

Andersen Jan Terje, Dalhus Bjørn, Cameron Jason, Daba Muluneh Bekele, Plumridge Andrew, Evans Leslie, Brennan Stephan O, Gunnarsen Kristin Støen, Bjørås Magnar, Sleep Darrell, Sandlie Inger
Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor.
Nat Commun 2012;3(3):610.  

Vik Erik Sebastian, Alseth Ingrun, Forsbring Monika, Helle Ina Høydal, Morland Ingrid, Luna Luisa, Bjørås Magnar, Dalhus Bjørn
Biochemical mapping of human NEIL1 DNA glycosylase and AP lyase activities.
DNA Repair (Amst) 2012 Sep;11(9):766-73. Epub 2012 aug 1
PMID: 22858590

Zegeye Ephrem Debebe, Balasingham Seetha V, Laerdahl Jon K, Homberset Håvard, Tønjum Tone
Mycobacterium tuberculosis RecG binds and unwinds model DNA substrates with a preference for Holliday junctions.
Microbiology 2012 Aug;158(Pt 8):1982-93. Epub 2012 mai 24
PMID: 22628485

Fladeby Cathrine, Vik Erik Sebastian, Laerdahl Jon K, Gran Neurauter Christine, Heggelund Julie E, Thorgaard Eirik, Strøm-Andersen Pernille, Bjørås Magnar, Dalhus Bjørn, Alseth Ingrun
The human homolog of Escherichia coli endonuclease V is a nucleolar protein with affinity for branched DNA structures.
PLoS One 2012;7(11):e47466. Epub 2012 nov 5
PMID: 23139746

Ellinghaus David, Folseraas Trine, Holm Kristian, Ellinghaus Eva, Melum Espen, Balschun Tobias, Laerdahl Jon K, Shiryaev Alexey, Gotthardt Daniel N, Weismüller Tobias J, Schramm Christoph, Wittig Michael, Bergquist Annika, Björnsson Einar, Marschall Hanns-Ulrich, Vatn Morten, Teufel Andreas, Rust Christian, Gieger Christian, Wichmann H-Erich, Runz Heiko, Sterneck Martina, Rupp Christian, Braun Felix, Weersma Rinse K, Wijmenga Cisca, Ponsioen Cyriel Y, Mathew Christopher G, Rutgeerts Paul, Vermeire Séverine, Schrumpf Erik, Hov Johannes R, Manns Michael P, Boberg Kirsten M, Schreiber Stefan, Franke Andre, Karlsen Tom H
Genome-wide association analysis in Primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4.
Hepatology 2012 Jul. Epub 2012 jul 23
PMID: 22821403

Balasingham Seetha V, Zegeye Ephrem Debebe, Homberset Håvard, Rossi Marie L, Laerdahl Jon K, Bohr Vilhelm A, Tønjum Tone
Enzymatic activities and DNA substrate specificity of Mycobacterium tuberculosis DNA helicase XPB.
PLoS One 2012;7(5):e36960. Epub 2012 mai 16
PMID: 22615856

Folseraas Trine, Melum Espen, Rausch Philipp, Juran Brian D, Ellinghaus Eva, Shiryaev Alexey, Laerdahl Jon K, Ellinghaus David, Schramm Christoph, Weismüller Tobias J, Gotthardt Daniel Nils, Hov Johannes Roksund, Clausen Ole Petter, Weersma Rinse K, Janse Marcel, Boberg Kirsten Muri, Björnsson Einar, Marschall Hanns-Ulrich, Cleynen Isabelle, Rosenstiel Philip, Holm Kristian, Teufel Andreas, Rust Christian, Gieger Christian, Wichmann H-Erich, Bergquist Annika, Ryu Euijung, Ponsioen Cyriel Y, Runz Heiko, Sterneck Martina, Vermeire Severine, Beuers Ulrich, Wijmenga Cisca, Schrumpf Erik, Manns Michael P, Lazaridis Konstantinos N, Schreiber Stefan, Baines John F, Franke Andre, Karlsen Tom H
Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci.
J Hepatol 2012 Aug;57(2):366-75. Epub 2012 apr 18
PMID: 22521342

Korvald Hanne, Falnes Pål Ø, Laerdahl Jon K, Bjørås Magnar, Alseth Ingrun
The Schizosaccharomyces pombe AlkB homolog Abh1 exhibits AP lyase activity but no demethylase activity.
DNA Repair (Amst) 2012 May;11(5):453-62. Epub 2012 feb 23
PMID: 22365419

Tveten Kristian, Holla Øystein L, Cameron Jamie, Strøm Thea Bismo, Berge Knut Erik, Laerdahl Jon K, Leren Trond P
Interaction between the ligand-binding domain of the LDL receptor and the C-terminal domain of PCSK9 is required for PCSK9 to remain bound to the LDL receptor during endosomal acidification.
Hum Mol Genet 2012 Mar;21(6):1402-9. Epub 2011 des 8
PMID: 22156580

Møllersen Linda, Rowe Alexander D, Illuzzi Jennifer L, Hildrestrand Gunn A, Gerhold Katharina J, Tveterås Linda, Bjølgerud Anja, Wilson David M, Bjørås Magnar, Klungland Arne
Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice.
Hum Mol Genet 2012 Nov;21(22):4939-47. Epub 2012 aug 21
PMID: 22914735

Ranneberg-Nilsen Toril, Rollag Halvor, Slettebakk Ragnhild, Backe Paul Hoff, Olsen Øyvind, Luna Luisa, Bjørås Magnar
The chromatin remodeling factor SMARCB1 forms a complex with human cytomegalovirus proteins UL114 and UL44.
PLoS One 2012;7(3):e34119. Epub 2012 mar 27
PMID: 22479537

Hereng Tuva H, Backe Paul H, Kahmann Jan, Scheich Christoph, Bjørås Magnar, Skålhegg Bjørn S, Rosendal Ken R
Structure and function of the human sperm-specific isoform of protein kinase A (PKA) catalytic subunit Ca2.
J Struct Biol 2012 Jun;178(3):300-10. Epub 2012 apr 6
PMID: 22504716

Søberg Kristoffer, Larsen Anja C V, Diskar Mandy, Backe Paul H, Bjørås Magnar, Jahnsen Tore, Laerdahl Jon K, Rognes Torbjørn, Herberg Friedrich W, Skålhegg Bjørn S
Identification and characterization of novel mutations in the human gene encoding the catalytic subunit Calpha of protein kinase A (PKA).
PLoS One 2012;7(4):e34838. Epub 2012 apr 13
PMID: 22514673

Bliksrud Yngve T, Brodtkorb Else, Backe Paul H, Woldseth Berit, Rootwelt Helge
Hereditary tyrosinaemia type I in Norway: incidence and three novel small deletions in the fumarylacetoacetase gene.
Scand J Clin Lab Invest 2012 Sep;72(5):369-73. Epub 2012 mai 4
PMID: 22554029

Payne Christina M, Baban Jamil, Horn Svein J, Backe Paul H, Arvai Andrew S, Dalhus Bjørn, Bjørås Magnar, Eijsink Vincent G H, Sørlie Morten, Beckham Gregg T, Vaaje-Kolstad Gustav
Hallmarks of processivity in glycoside hydrolases from crystallographic and computational studies of the Serratia marcescens chitinases.
J Biol Chem 2012 Oct;287(43):36322-30. Epub 2012 sep 5
PMID: 22952223

Publications 2011

Holla Øystein L, Cameron Jamie, Tveten Kristian, Strøm Thea Bismo, Berge Knut Erik, Laerdahl Jon K, Leren Trond P
Role of the C-terminal domain of PCSK9 in degradation of the LDL receptors.
J Lipid Res 2011 Oct;52(10):1787-94. Epub 2011 jul 19
PMID: 21771976

Holla Øystein L, Laerdahl Jon K, Strøm Thea Bismo, Tveten Kristian, Cameron Jamie, Berge Knut Erik, Leren Trond P
Removal of acidic residues of the prodomain of PCSK9 increases its activity towards the LDL receptor.
Biochem Biophys Res Commun 2011 Mar;406(2):234-8. Epub 2011 feb 13
PMID: 21324305

Dalhus Bjørn, Forsbring Monika, Helle Ina Høydal, Vik Erik Sebastian, Forstrøm Rune Johansen, Backe Paul Hoff, Alseth Ingrun, Bjørås Magnar
Separation-of-function mutants unravel the dual-reaction mode of human 8-oxoguanine DNA glycosylase.
Structure 2011 Jan;19(1):117-27.
PMID: 21220122

Korvald Hanne, Mølstad Moe Anne Margrethe, Cederkvist F Henning, Thiede Bernd, Laerdahl Jon K, Bjørås Magnar, Alseth Ingrun
Schizosaccharomyces pombe Ofd2 is a nuclear 2-oxoglutarate and iron dependent dioxygenase interacting with histones.
PLoS One 2011;6(9):e25188. Epub 2011 sep 16
PMID: 21949882

Laerdahl Jon K, Korvald Hanne, Nilsen Line, Dahl-Michelsen Kristin, Rognes Torbjørn, Bjørås Magnar, Alseth Ingrun
Schizosaccharomyces pombe encodes a mutated AP endonuclease 1.
DNA Repair (Amst) 2011 Mar;10(3):296-305. Epub 2010 des 28
PMID: 21193357

Lauritzen Knut H, Dalhus Bjørn, Storm Johan F, Bjørås Magnar, Klungland Arne
Modeling the impact of mitochondrial DNA damage in forebrain neurons and beyond.
Mech Ageing Dev 2011 Aug;132(8-9):424-8. Epub 2011 feb 25
PMID: 21354441

Melum Espen, Franke Andre, Schramm Christoph, Weismüller Tobias J, Gotthardt Daniel Nils, Offner Felix A, Juran Brian D, Laerdahl Jon K, Labi Verena, Björnsson Einar, Weersma Rinse K, Henckaerts Liesbet, Teufel Andreas, Rust Christian, Ellinghaus Eva, Balschun Tobias, Boberg Kirsten Muri, Ellinghaus David, Bergquist Annika, Sauer Peter, Ryu Euijung, Hov Johannes Roksund, Wedemeyer Jochen, Lindkvist Björn, Wittig Michael, Porte Robert J, Holm Kristian, Gieger Christian, Wichmann H-Erich, Stokkers Pieter, Ponsioen Cyriel Y, Runz Heiko, Stiehl Adolf, Wijmenga Cisca, Sterneck Martina, Vermeire Severine, Beuers Ulrich, Villunger Andreas, Schrumpf Erik, Lazaridis Konstantinos N, Manns Michael P, Schreiber Stefan, Karlsen Tom H
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.
Nat Genet 2011 Jan;43(1):17-9. Epub 2010 des 12
PMID: 21151127

Benam Afsaneh V, Lång Emma, Alfsnes Kristian, Fleckenstein Burkhard, Rowe Alexander D, Hovland Eirik, Ambur Ole Herman, Frye Stephan A, Tønjum Tone
Structure-function relationships of the competence lipoprotein ComL and SSB in meningococcal transformation.
Microbiology 2011 May;157(Pt 5):1329-42. Epub 2011 feb 17
PMID: 21330432

Tveten Kristian, Holla Øystein L, Cameron Jamie, Strøm Thea Bismo, Berge Knut Erik, Laerdahl Jon K, Leren Trond P
Interaction between the ligand-binding domain of the LDL receptor and the C-terminal domain of PCSK9 is required for PCSK9 to remain bound to the LDL receptor during endosomal acidification.
Hum Mol Genet 2012 Mar;21(6):1402-9. Epub 2011 des 8
PMID: 22156580

Yang Mingyi, Aamodt Randi M, Dalhus Bjørn, Balasingham Seetha, Helle Ina, Andersen Pernille, Tønjum Tone, Alseth Ingrun, Rognes Torbjørn, Bjørås Magnar
The ada operon of Mycobacterium tuberculosis encodes two DNA methyltransferases for inducible repair of DNA alkylation damage.
DNA Repair (Amst) 2011 Jun;10(6):595-602. Epub 2011 mai 12
PMID: 21570366

Publications 2010

Brodtkorb Else, Strand Janne, Backe Paul Hoff, Lund Anne Marie, Bjørås Magnar, Rootwelt Terje, Rootwelt Helge, Woldseth Berit, Eide Lars
Four novel mutations identified in Norwegian patients result in intermittent maple syrup urine disease when combined with the R301C mutation.
Mol Genet Metab 2010 Aug;100(4):324-32. Epub 2010 mai 31
PMID: 20570198

Laerdahl Jon K, Korvald Hanne, Nilsen Line, Dahl-Michelsen Kristin, Rognes Torbjørn, Bjørås Magnar, Alseth Ingrun
Schizosaccharomyces pombe encodes a mutated AP endonuclease 1.
DNA Repair (Amst) 2011 Mar;10(3):296-305. Epub 2010 des 28
PMID: 21193357

Hov Johannes R, Keitel Verena, Laerdahl Jon K, Spomer Lina, Ellinghaus Eva, ElSharawy Abdou, Melum Espen, Boberg Kirsten M, Manke Thomas, Balschun Tobias, Schramm Christoph, Bergquist Annika, Weismüller Tobias, Gotthardt Daniel, Rust Christian, Henckaerts Liesbet, Onnie Clive M, Weersma Rinse K, Sterneck Martina, Teufel Andreas, Runz Heiko, Stiehl Adolf, Ponsioen Cyriel Y, Wijmenga Cisca, Vatn Morten H, PubMed.ItemsChoiceType2[], Stokkers Pieter C F, Vermeire Severine, Mathew Christopher G, Lie Benedicte A, Beuers Ulrich, Manns Michael P, Schreiber Stefan, Schrumpf Erik, Häussinger Dieter, Franke Andre, Karlsen Tom H
Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis.
PLoS One 2010;5(8):e12403. Epub 2010 aug 25
PMID: 20811628

Publications 2009

Dalhus Bjørn, Arvai Andrew S, Rosnes Ida, Olsen Øyvind E, Backe Paul H, Alseth Ingrun, Gao Honghai, Cao Weiguo, Tainer John A, Bjørås Magnar
Structures of endonuclease V with DNA reveal initiation of deaminated adenine repair.
Nat Struct Mol Biol 2009 Feb;16(2):138-43. Epub 2009 jan 11
PMID: 19136958

Hol Johanna, Küchler Axel M, Johansen Finn-Eirik, Dalhus Bjørn, Haraldsen Guttorm, Oynebråten Inger
Molecular requirements for sorting of the chemokine interleukin-8/CXCL8 to endothelial Weibel-Palade bodies.
J Biol Chem 2009 Aug;284(35):23532-9. Epub 2009 jul 3
PMID: 19578117

Forsbring Monika, Vik Erik S, Dalhus Bjørn, Karlsen Tom H, Bergquist Annika, Schrumpf Erik, Bjørås Magnar, Boberg Kirsten M, Alseth Ingrun
Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma.
Carcinogenesis 2009 Jul;30(7):1147-54. Epub 2009 mai 14
PMID: 19443904

Nordlund Marianne S, Warren David J, Laerdahl Jon K, Paus Elisabeth
Studies on multiple forms of proGRP in serum from small cell lung cancer patients.
Tumour Biol 2009;30(5-6):265-75. Epub 2009 nov 12
PMID: 19907206

Cameron Jamie, Holla Øystein L, Laerdahl Jon K, Kulseth Mari Ann, Berge Knut Erik, Leren Trond P
Mutation S462P in the PCSK9 gene reduces secretion of mutant PCSK9 without affecting the autocatalytic cleavage.
Atherosclerosis 2009 Mar;203(1):161-5. Epub 2008 okt 17
PMID: 19022446

Dalhus Bjørn, Laerdahl Jon K, Backe Paul H, Bjørås Magnar
DNA base repair--recognition and initiation of catalysis.
FEMS Microbiol Rev 2009 Nov;33(6):1044-78. Epub 2009 jul 3
PMID: 19659577

Krokeide Silje Z, Bolstad Nils, Laerdahl Jon K, Bjørås Magnar, Luna Luisa
Expression and purification of NEIL3, a human DNA glycosylase homolog.
Protein Expr Purif 2009 Jun;65(2):160-4. Epub 2008 des 13
PMID: 19121397