Publications 2024

Akdeniz BC, Frei O, Hagen E, Filiz TT, Karthikeyan S, Pasman J, Jangmo A, Bergstedt J, Shorter JR, Zetterberg R, Meijsen J, Sønderby IE, Buil A, Tesli M, Lu Y, Sullivan P, Andreassen OA, Hovig E (2024)
COSGAP: COntainerized Statistical Genetics Analysis Pipelines
Bioinform Adv, 4 (1), vbae067
DOI 10.1093/bioadv/vbae067, PubMed 38808072

Andersson P, Linge J, Gurholt TP, Sønderby IE, Hindley G, Andreassen OA, Dahlqvist Leinhard O (2024)
Poor muscle health and cardiometabolic risks associated with antidepressant treatment
Obesity (Silver Spring), 32 (10), 1857-1869
DOI 10.1002/oby.24085, PubMed 39315407

Gurholt TP, Borda MG, Parker N, Fominykh V, Kjelkenes R, Linge J, van der Meer D, Sønderby IE, Duque G, Westlye LT, Aarsland D, Andreassen OA (2024)
Linking sarcopenia, brain structure and cognitive performance: a large-scale UK Biobank study
Brain Commun, 6 (2), fcae083
DOI 10.1093/braincomms/fcae083, PubMed 38510210

Gurholt TP, Elvsåshagen T, Bahrami S, Rahman Z, Shadrin A, Askeland-Gjerde DE, van der Meer D, Frei O, Kaufmann T, Sønderby IE, Halvorsen S, Westlye LT, Andreassen OA (2024)
Large-scale brainstem neuroimaging and genetic analyses provide new insights into the neuronal mechanisms of hypertension
HGG Adv, 6 (1), 100392
DOI 10.1016/j.xhgg.2024.100392, PubMed 39663699

Ivarsdottir EV, Gudmundsson J, Tragante V, Sveinbjornsson G, Kristmundsdottir S, Stacey SN, Halldorsson GH, Magnusson MI, Oddsson A, Walters GB, Sigurdsson A, Saevarsdottir S, Beyter D, Thorleifsson G, Halldorsson BV, Melsted P, Stefansson H, Jonsdottir I, Sørensen E, Pedersen OB, Erikstrup C, Bøgsted M, Pøhl M, Røder A, Stroomberg HV et al. (2024)
Gene-based burden tests of rare germline variants identify six cancer susceptibility genes
Nat Genet, 56 (11), 2422-2433
DOI 10.1038/s41588-024-01966-6, PubMed 39472694

Kopal J, Kumar K, Shafighi K, Saltoun K, Modenato C, Moreau CA, Huguet G, Jean-Louis M, Martin CO, Saci Z, Younis N, Douard E, Jizi K, Beauchamp-Chatel A, Kushan L, Silva AI, van den Bree MBM, Linden DEJ, Owen MJ, Hall J, Lippé S, Draganski B, Sønderby IE, Andreassen OA, Glahn DC et al. (2024)
Using rare genetic mutations to revisit structural brain asymmetry
Nat Commun, 15 (1), 2639
DOI 10.1038/s41467-024-46784-w, PubMed 38531844

Kopal J, Kumar K, Shafighi K, Saltoun K, Modenato C, Moreau CA, Huguet G, Jean-Louis M, Martin CO, Saci Z, Younis N, Douard E, Jizi K, Beauchamp-Chatel A, Kushan L, Silva AI, van den Bree MBM, Linden DEJ, Owen MJ, Hall J, Lippé S, Draganski B, Sønderby IE, Andreassen OA, Glahn DC et al. (2024)
Author Correction: Using rare genetic mutations to revisit structural brain asymmetry
Nat Commun, 15 (1), 3098
DOI 10.1038/s41467-024-47545-5, PubMed 38600109

Szabo A, O'Connell KS, Akkouh IA, Ueland T, Sønderby IE, Hope S, Røe AB, Dønnum MS, Sjaastad I, Steen NE, Ueland T, Sæther LS, Osete JR, Andreassen OA, Nærland T, Djurovic S (2024)
Elevated levels of peripheral and central nervous system immune markers reflect innate immune dysregulation in autism spectrum disorder
Psychiatry Res, 342, 116245
DOI 10.1016/j.psychres.2024.116245, PubMed 39481220

Publications 2023

Boen R, Kaufmann T, Frei O, van der Meer D, Djurovic S, Andreassen OA, Selmer KK, Alnæs D, Sønderby IE (2023)
No signs of neurodegenerative effects in 15q11.2 BP1-BP2 copy number variant carriers in the UK Biobank
Transl Psychiatry, 13 (1), 61
DOI 10.1038/s41398-023-02358-w, PubMed 36807331

Boen R, Kaufmann T, van der Meer D, Frei O, Agartz I, Ames D, Andersson M, Armstrong NJ, Artiges E, Atkins JR, Bauer J, Benedetti F, Boomsma DI, Brodaty H, Brosch K, Buckner RL, Cairns MJ, Calhoun V, Caspers S, Cichon S, Corvin AP, Crespo-Facorro B, Dannlowski U, David FS, de Geus EJC et al. (2023)
Beyond the Global Brain Differences: Intraindividual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers
Biol Psychiatry, 95 (2), 147-160
DOI 10.1016/j.biopsych.2023.08.018, PubMed 37661008

Kopal J, Kumar K, Saltoun K, Modenato C, Moreau CA, Martin-Brevet S, Huguet G, Jean-Louis M, Martin CO, Saci Z, Younis N, Tamer P, Douard E, Maillard AM, Rodriguez-Herreros B, Pain A, Richetin S, Kushan L, Silva AI, van den Bree MBM, Linden DEJ, Owen MJ, Hall J, Lippé S, Draganski B et al. (2023)
Rare CNVs and phenome-wide profiling highlight brain structural divergence and phenotypical convergence
Nat Hum Behav, 7 (6), 1001-1017
DOI 10.1038/s41562-023-01541-9, PubMed 36864136

Kumar K, Modenato C, Moreau C, Ching CRK, Harvey A, Martin-Brevet S, Huguet G, Jean-Louis M, Douard E, Martin CO, Younis N, Tamer P, Maillard AM, Rodriguez-Herreros B, Pain A, 16p11.2 European Consortium, Simons Searchlight Consortium, Kushan L, Isaev D, Alpert K, Ragothaman A, Turner JA, Wang L, Ho TC, Schmaal L, Silva AI et al. (2023)
Subcortical Brain Alterations in Carriers of Genomic Copy Number Variants
Am J Psychiatry, 180 (9), 685-698
DOI 10.1176/appi.ajp.20220304, PubMed 37434504

Oddsson A, Sulem P, Sveinbjornsson G, Arnadottir GA, Steinthorsdottir V, Halldorsson GH, Atlason BA, Oskarsson GR, Helgason H, Nielsen HS, Westergaard D, Karjalainen JM, Katrinardottir H, Fridriksdottir R, Jensson BO, Tragante V, Ferkingstad E, Jonsson H, Gudjonsson SA, Beyter D, Moore KHS, Thordardottir HB, Kristmundsdottir S, Stefansson OA, Rantapää-Dahlqvist S et al. (2023)
Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality
Nat Commun, 14 (1), 3453
DOI 10.1038/s41467-023-38951-2, PubMed 37301908

Oddsson A, Sulem P, Sveinbjornsson G, Arnadottir GA, Steinthorsdottir V, Halldorsson GH, Atlason BA, Oskarsson GR, Helgason H, Nielsen HS, Westergaard D, Karjalainen JM, Katrinardottir H, Fridriksdottir R, Jensson BO, Tragante V, Ferkingstad E, Jonsson H, Gudjonsson SA, Beyter D, Moore KHS, Thordardottir HB, Kristmundsdottir S, Stefansson OA, Rantapää-Dahlqvist S et al. (2023)
Publisher Correction: Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality
Nat Commun, 14 (1), 3923
DOI 10.1038/s41467-023-39492-4, PubMed 37400429

Publications 2022

Granerud G, Elvsåshagen T, Arntzen E, Juhasz K, Emilsen NM, Sønderby IE, Nærland T, Malt EA (2022)
A family study of symbolic learning and synaptic plasticity in autism spectrum disorder
Front Hum Neurosci, 16, 950922
DOI 10.3389/fnhum.2022.950922, PubMed 36504626

van der Meer D, Gurholt TP, Sønderby IE, Shadrin AA, Hindley G, Rahman Z, de Lange AG, Frei O, Leinhard OD, Linge J, Simon R, Beck D, Westlye LT, Halvorsen S, Dale AM, Karlsen TH, Kaufmann T, Andreassen OA (2022)
The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition
Commun Biol, 5 (1), 1271
DOI 10.1038/s42003-022-04237-4, PubMed 36402844

Publications 2021

Gurholt TP, Kaufmann T, Frei O, Alnæs D, Haukvik UK, van der Meer D, Moberget T, O'Connell KS, Leinhard OD, Linge J, Simon R, Smeland OB, Sønderby IE, Winterton A, Steen NE, Westlye LT, Andreassen OA (2021)
Population-based body-brain mapping links brain morphology with anthropometrics and body composition
Transl Psychiatry, 11 (1), 295
DOI 10.1038/s41398-021-01414-7, PubMed 34006848

Modenato C, Martin-Brevet S, Moreau CA, Rodriguez-Herreros B, Kumar K, Draganski B, Sønderby IE, Jacquemont S (2021)
Lessons Learned From Neuroimaging Studies of Copy Number Variants: A Systematic Review
Biol Psychiatry, 90 (9), 596-610
DOI 10.1016/j.biopsych.2021.05.028, PubMed 34509290

O'Connell KS, Sønderby IE, Frei O, van der Meer D, Athanasiu L, Smeland OB, Alnæs D, Kaufmann T, Westlye LT, Steen VM, Andreassen OA, Hughes T, Djurovic S (2021)
Association between complement component 4A expression, cognitive performance and brain imaging measures in UK Biobank
Psychol Med, 52 (15), 1-11 (in press)
DOI 10.1017/S0033291721000179, PubMed 33653435

Sønderby IE, Ching CRK, Thomopoulos SI, van der Meer D, Sun D, Villalon-Reina JE, Agartz I, Amunts K, Arango C, Armstrong NJ, Ayesa-Arriola R, Bakker G, Bassett AS, Boomsma DI, Bülow R, Butcher NJ, Calhoun VD, Caspers S, Chow EWC, Cichon S, Ciufolini S, Craig MC, Crespo-Facorro B, Cunningham AC, Dale AM et al. (2021)
Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs
Hum Brain Mapp, 43 (1), 300-328
DOI 10.1002/hbm.25354, PubMed 33615640

Sønderby IE, van der Meer D, Moreau C, Kaufmann T, Walters GB, Ellegaard M, Abdellaoui A, Ames D, Amunts K, Andersson M, Armstrong NJ, Bernard M, Blackburn NB, Blangero J, Boomsma DI, Brodaty H, Brouwer RM, Bülow R, Bøen R, Cahn W, Calhoun VD, Caspers S, Ching CRK, Cichon S, Ciufolini S et al. (2021)
1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans
Transl Psychiatry, 11 (1), 182
DOI 10.1038/s41398-021-01213-0, PubMed 33753722

Publications 2020

Córdova-Palomera A, van der Meer D, Kaufmann T, Bettella F, Wang Y, Alnæs D, Doan NT, Agartz I, Bertolino A, Buitelaar JK, Coynel D, Djurovic S, Dørum ES, Espeseth T, Fazio L, Franke B, Frei O, Håberg A, Le Hellard S, Jönsson EG, Kolskår KK, Lund MJ, Moberget T, Nordvik JE, Nyberg L et al. (2020)
Genetic control of variability in subcortical and intracranial volumes
Mol Psychiatry, 26 (8), 3876-3883
DOI 10.1038/s41380-020-0664-1, PubMed 32047264

Grasby KL, Jahanshad N, Painter JN, Colodro-Conde L, Bralten J, Hibar DP, Lind PA, Pizzagalli F, Ching CRK, McMahon MAB, Shatokhina N, Zsembik LCP, Thomopoulos SI, Zhu AH, Strike LT, Agartz I, Alhusaini S, Almeida MAA, Alnæs D, Amlien IK, Andersson M, Ard T, Armstrong NJ, Ashley-Koch A, Atkins JR et al. (2020)
The genetic architecture of the human cerebral cortex
Science, 367 (6484)
DOI 10.1126/science.aay6690, PubMed 32193296

Sønderby IE, Gústafsson Ó, Doan NT, Hibar DP, Martin-Brevet S, Abdellaoui A, Ames D, Amunts K, Andersson M, Armstrong NJ, Bernard M, Blackburn N, Blangero J, Boomsma DI, Bralten J, Brattbak HR, Brodaty H, Brouwer RM, Bülow R, Calhoun V, Caspers S, Cavalleri G, Chen CH, Cichon S, Ciufolini S et al. (2020)
Correction: Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia
Mol Psychiatry, 25 (3), 692-695
DOI 10.1038/s41380-019-0358-8, PubMed 30705424

Thompson PM, Jahanshad N, Ching CRK, Salminen LE, Thomopoulos SI, Bright J, Baune BT, Bertolín S, Bralten J, Bruin WB, Bülow R, Chen J, Chye Y, Dannlowski U, de Kovel CGF, Donohoe G, Eyler LT, Faraone SV, Favre P, Filippi CA, Frodl T, Garijo D, Gil Y, Grabe HJ, Grasby KL et al. (2020)
ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries
Transl Psychiatry, 10 (1), 100
DOI 10.1038/s41398-020-0705-1, PubMed 32198361

Writing Committee for the ENIGMA-CNV Working Group, van der Meer D, Sønderby IE, Kaufmann T, Walters GB, Abdellaoui A, Ames D, Amunts K, Andersson M, Armstrong NJ, Bernard M, Blackburn NB, Blangero J, Boomsma DI, Brodaty H, Brouwer RM, Bülow R, Cahn W, Calhoun VD, Caspers S, Cavalleri GL, Ching CRK, Cichon S, Ciufolini S, Corvin A et al. (2020)
Association of Copy Number Variation of the 15q11.2 BP1-BP2 Region With Cortical and Subcortical Morphology and Cognition
JAMA Psychiatry, 77 (4), 420-430
DOI 10.1001/jamapsychiatry.2019.3779, PubMed 31665216

Publications 2019

Gudmundsson OO, Walters GB, Ingason A, Johansson S, Zayats T, Athanasiu L, Sonderby IE, Gustafsson O, Nawaz MS, Jonsson GF, Jonsson L, Knappskog PM, Ingvarsdottir E, Davidsdottir K, Djurovic S, Knudsen GPS, Askeland RB, Haraldsdottir GS, Baldursson G, Magnusson P, Sigurdsson E, Gudbjartsson DF, Stefansson H, Andreassen OA, Haavik J et al. (2019)
Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder
Transl Psychiatry, 9 (1), 258
DOI 10.1038/s41398-019-0599-y, PubMed 31624239

Publications 2018

Córdova-Palomera A, Kaufmann T, Bettella F, Wang Y, Doan NT, van der Meer D, Alnæs D, Rokicki J, Moberget T, Sønderby IE, Andreassen OA, Westlye LT (2018)
Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories
Eur J Hum Genet, 26 (7), 1049-1059
DOI 10.1038/s41431-018-0134-2, PubMed 29700391

Hughes T, Sønderby IE, Polushina T, Hansson L, Holmgren A, Athanasiu L, Melbø-Jørgensen C, Hassani S, Hoeffding LK, Herms S, Bergen SE, Karlsson R, Song J, Rietschel M, Nöthen MM, Forstner AJ, Hoffmann P, Hultman CM, Landén M, Cichon S, Werge T, Andreassen OA, Le Hellard S, Djurovic S (2018)
Elevated expression of a minor isoform of ANK3 is a risk factor for bipolar disorder
Transl Psychiatry, 8 (1), 210
DOI 10.1038/s41398-018-0175-x, PubMed 30297702

Stokowy T, Polushina T, Sønderby IE, Karlsson R, Giddaluru S, Le Hellard S, Bergen SE, Sullivan PF, Andreassen OA, Djurovic S, Hultman CM, Steen VM (2018)
Genetic variation in 117 myelination-related genes in schizophrenia: Replication of association to lipid biosynthesis genes
Sci Rep, 8 (1), 6915
DOI 10.1038/s41598-018-25280-4, PubMed 29720671

Sønderby IE, Gústafsson Ó, Doan NT, Hibar DP, Martin-Brevet S, Abdellaoui A, Ames D, Amunts K, Andersson M, Armstrong NJ, Bernard M, Blackburn N, Blangero J, Boomsma DI, Bralten J, Brattbak HR, Brodaty H, Brouwer RM, Bülow R, Calhoun V, Caspers S, Cavalleri G, Chen CH, Cichon S, Ciufolini S et al. (2018)
Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia
Mol Psychiatry, 25 (3), 584-602
DOI 10.1038/s41380-018-0118-1, PubMed 30283035

van der Meer D, Rokicki J, Kaufmann T, Córdova-Palomera A, Moberget T, Alnæs D, Bettella F, Frei O, Doan NT, Sønderby IE, Smeland OB, Agartz I, Bertolino A, Bralten J, Brandt CL, Buitelaar JK, Djurovic S, van Donkelaar M, Dørum ES, Espeseth T, Faraone SV, Fernández G, Fisher SE, Franke B, Haatveit B et al. (2018)
Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes
Mol Psychiatry, 25 (11), 3053-3065
DOI 10.1038/s41380-018-0262-7, PubMed 30279459

Publications 2015

Athanasiu L, Smorr LL, Tesli M, Røssberg JI, Sønderby IE, Spigset O, Djurovic S, Andreassen OA (2015)
Genome-wide association study identifies common variants associated with pharmacokinetics of psychotropic drugs
J Psychopharmacol, 29 (8), 884-91
DOI 10.1177/0269881115584469, PubMed 25944848

Goulart LF, Bettella F, Sønderby IE, Schork AJ, Thompson WK, Mattingsdal M, Steen VM, Zuber V, Wang Y, Dale AM, PRACTICAL/ELLIPSE consortium, Andreassen OA, Djurovic S (2015)
MicroRNAs enrichment in GWAS of complex human phenotypes
BMC Genomics, 16 (1), 304
DOI 10.1186/s12864-015-1513-5, PubMed 25884492

Hughes T, Hansson L, Sønderby IE, Athanasiu L, Zuber V, Tesli M, Song J, Hultman CM, Bergen SE, Landén M, Melle I, Andreassen OA, Djurovic S (2015)
A Loss-of-Function Variant in a Minor Isoform of ANK3 Protects Against Bipolar Disorder and Schizophrenia
Biol Psychiatry, 80 (4), 323-330
DOI 10.1016/j.biopsych.2015.09.021, PubMed 26682468

Publications 2014

Zai CC, Manchia M, Sønderby IE, Yilmaz Z, De Luca V, Tiwari AK, Squassina A, Zai GC, Shaikh SA, Strauss J, King N, Le Foll B, Kaplan AS, Finseth PI, Vaaler AE, Djurovic S, Andreassen OA, Vincent JB, Kennedy JL (2014)
Investigation of the genetic interaction between BDNF and DRD3 genes in suicidical behaviour in psychiatric disorders
World J Biol Psychiatry, 16 (3), 171-9
DOI 10.3109/15622975.2014.953011, PubMed 25264289

Publications 2013

Finseth PI, Sønderby IE, Djurovic S, Agartz I, Malt UF, Melle I, Morken G, Andreassen OA, Vaaler AE, Tesli M (2013)
Association analysis between suicidal behaviour and candidate genes of bipolar disorder and schizophrenia
J Affect Disord, 163, 110-4
DOI 10.1016/j.jad.2013.12.018, PubMed 24461634

Tesli M, Egeland R, Sønderby IE, Haukvik UK, Bettella F, Hibar DP, Thompson PM, Rimol LM, Melle I, Agartz I, Djurovic S, Andreassen OA (2013)
No evidence for association between bipolar disorder risk gene variants and brain structural phenotypes
J Affect Disord, 151 (1), 291-7
DOI 10.1016/j.jad.2013.06.008, PubMed 23820096

Publications 2012

Mattingsdal M, Brown AA, Djurovic S, Sønderby IE, Server A, Melle I, Agartz I, Hovig E, Jensen J, Andreassen OA (2012)
Pathway analysis of genetic markers associated with a functional MRI faces paradigm implicates polymorphisms in calcium responsive pathways
Neuroimage, 70, 143-9
DOI 10.1016/j.neuroimage.2012.12.035, PubMed 23274185

Whiteman NK, Gloss AD, Sackton TB, Groen SC, Humphrey PT, Lapoint RT, Sønderby IE, Halkier BA, Kocks C, Ausubel FM, Pierce NE (2012)
Genes involved in the evolution of herbivory by a leaf-mining, Drosophilid fly
Genome Biol Evol, 4 (9), 900-16
DOI 10.1093/gbe/evs063, PubMed 22813779

Publications 2010

Müller R, de Vos M, Sun JY, Sønderby IE, Halkier BA, Wittstock U, Jander G (2010)
Differential effects of indole and aliphatic glucosinolates on lepidopteran herbivores
J Chem Ecol, 36 (8), 905-13
DOI 10.1007/s10886-010-9825-z, PubMed 20617455

Sønderby IE, Burow M, Rowe HC, Kliebenstein DJ, Halkier BA (2010)
A complex interplay of three R2R3 MYB transcription factors determines the profile of aliphatic glucosinolates in Arabidopsis
Plant Physiol, 153 (1), 348-63
DOI 10.1104/pp.109.149286, PubMed 20348214

Sønderby IE, Geu-Flores F, Halkier BA (2010)
Biosynthesis of glucosinolates--gene discovery and beyond
Trends Plant Sci, 15 (5), 283-90
DOI 10.1016/j.tplants.2010.02.005, PubMed 20303821

Publications 2009

Sun JY, Sønderby IE, Halkier BA, Jander G, de Vos M (2009)
Non-volatile intact indole glucosinolates are host recognition cues for ovipositing Plutella xylostella
J Chem Ecol, 35 (12), 1427-36
DOI 10.1007/s10886-009-9723-4, PubMed 20054620

Publications 2007

Sønderby IE, Hansen BG, Bjarnholt N, Ticconi C, Halkier BA, Kliebenstein DJ (2007)
A systems biology approach identifies a R2R3 MYB gene subfamily with distinct and overlapping functions in regulation of aliphatic glucosinolates
PLoS One, 2 (12), e1322
DOI 10.1371/journal.pone.0001322, PubMed 18094747