Light Meets Precision:
EIC Pathfinder Project SCALPEL Pioneering a Revolutionary Photoimmunotherapy for Cancer
Theo Theodossiou, Project coordinator
In a groundbreaking effort to revolutionise modern oncology, the SCALPEL project launches a Europe wide initiative aimed at redefining cancer treatment by using light to precisely ‘click’ tags to cancer cells, enabling the immune system to recognise and destroy them with unparalleled accuracy. Project coordinator is Theo Theodossiou, head of the Protonics project group at the Department of Radiation Biology at OUH.
The multidisciplinary initiative funded by the European Innovation Council Pathfinder programme under Horizon Europe with a total budget of more than EUR 4 million aims to revolutionise modern oncology offering new hope for millions worldwide.
Published in Level 2 journals, first or last author from Oslo University Hospital.
Fleur du Pré M, Blazevski J, Dewan AE, Stamnaes J, Kanduri C, Sandve GK, Johannesen MK, Lindstad CB, Hnida K, Fugger L, Melino G, Qiao SW, Sollid LM(2026) Correction: B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2 J Exp Med, 223(3) DOI 10.1084/jem.2019086002062026c, PubMed 41678279
Rakaee M, Nassar AH, Tafavvoghi M, Jabar F, Bou Farhat E, Adib E, Andersen S, Busund LR, Pøhl M, Helland Å, Gusev A, Ricciuti B, Sholl LM, Donnem T, Kwiatkowski DJ(2026) Ancestry-Associated Performance Variability of Open-Source AI Models for EGFR Prediction in Lung Cancer JAMA Oncol(in press) DOI 10.1001/jamaoncol.2025.6430, PubMed 41678173
Kvam TM, Goksøyr IW, Rog J, van de Vooren IJ, Stewart LH, Autran I, Berthold-Losleben M, Mørch-Johnsen L, Holst R, Clausen I, Andreassen OA(2026) MDMA-assisted therapy as a treatment for major depressive disorder: proof of principle study - CORRIGENDUM Br J Psychiatry, 1(in press) DOI 10.1192/bjp.2026.10579, PubMed 41664469