Publications by Jo Waaler

20 publications found

Publications 2021

  1. Mygland L, Brinch SA, Strand MF, Olsen PA, Aizenshtadt A, Lund K, Solberg NT, Lycke M, Thorvaldsen TE, Espada S, Misaghian D, Page CM, Agafonov O, Nygård S, Chi NW, Lin E, Tan J, Yu Y, Costa M, Krauss S, Waaler J (2021)
    Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines
    iScience, 24 (7), 102807
    DOI 10.1016/j.isci.2021.102807, PubMed 34337362

Publications 2020

  1. Kierulf-Vieira KS, Sandberg CJ, Waaler J, Lund K, Skaga E, Saberniak BM, Panagopoulos I, Brandal P, Krauss S, Langmoen IA, Vik-Mo EO (2020)
    A Small-Molecule Tankyrase Inhibitor Reduces Glioma Stem Cell Proliferation and Sphere Formation
    Cancers (Basel), 12 (6)
    DOI 10.3390/cancers12061630, PubMed 32575464
  2. Lien VT, Kristiansen MK, Pettersen S, Haugen MH, Krauss S, Olberg DE, Waaler J, Klaveness J (2020)
    Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation (vol 9, pg 37092, 2019)
    RSC Adv., 10 (9), 4927
    DOI 10.1039/d0ra90007a
  3. Waaler J, Leenders RGG, Sowa ST, Alam Brinch S, Lycke M, Nieczypor P, Aertssen S, Murthy S, Galera-Prat A, Damen E, Wegert A, Nazaré M, Lehtiö L, Krauss S (2020)
    Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor
    J Med Chem, 63 (13), 6834-6846
    DOI 10.1021/acs.jmedchem.0c00208, PubMed 32511917
  4. Waaler J, Mygland L, Tveita A, Strand MF, Solberg NT, Olsen PA, Aizenshtadt A, Fauskanger M, Lund K, Brinch SA, Lycke M, Dybing E, Nygaard V, Bøe SL, Heintz KM, Hovig E, Hammarström C, Corthay A, Krauss S (2020)
    Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models
    Commun Biol, 3 (1), 196
    DOI 10.1038/s42003-020-0916-2, PubMed 32332858
  5. Wang H, Kuusela S, Rinnankoski-Tuikka R, Dumont V, Bouslama R, Ramadan UA, Waaler J, Linden AM, Chi NW, Krauss S, Pirinen E, Lehtonen S (2020)
    Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice
    Int J Obes (Lond), 44 (8), 1691-1702
    DOI 10.1038/s41366-020-0573-z, PubMed 32317752

Publications 2019

  1. Lien VT, Kristiansen MK, Pettersen S, Haugen MH, Olberg DE, Waaler J, Klaveness J (2019)
    Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation
    RSC Adv., 9 (63), 37092-37100
    DOI 10.1039/c9ra08954c

Publications 2018

  1. Norum JH, Skarpen E, Brech A, Kuiper R, Waaler J, Krauss S, Sørlie T (2018)
    The tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology
    Biol Res, 51 (1), 3
    DOI 10.1186/s40659-017-0151-6, PubMed 29316982

Publications 2017

  1. Anumala UR, Waaler J, Nkizinkiko Y, Ignatev A, Lazarow K, Lindemann P, Olsen PA, Murthy S, Obaji E, Majouga AG, Leonov S, von Kries JP, Lehtiö L, Krauss S, Nazaré M (2017)
    Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach
    J Med Chem, 60 (24), 10013-10025
    DOI 10.1021/acs.jmedchem.7b00883, PubMed 29155568
  2. Solberg NT, Waaler J, Lund K, Mygland L, Olsen PA, Krauss S (2017)
    TANKYRASE Inhibition Enhances the Antiproliferative Effect of PI3K and EGFR Inhibition, Mutually Affecting β-CATENIN and AKT Signaling in Colorectal Cancer
    Mol Cancer Res, 16 (3), 543-553
    DOI 10.1158/1541-7786.MCR-17-0362, PubMed 29222171
  3. Vehus T, Waaler J, Krauss S, Lundanes E, Wilson SR (2017)
    Combining HIC, SEC, and IEX with Fluorescence Polarization for Drug Target Discovery
    LC GC Eur., 30 (5), 232-239

Publications 2016

  1. Vehus T, Roberg-Larsen H, Waaler J, Aslaksen S, Krauss S, Wilson SR, Lundanes E (2016)
    Versatile, sensitive liquid chromatography mass spectrometry - Implementation of 10 μm OT columns suitable for small molecules, peptides and proteins
    Sci Rep, 6, 37507
    DOI 10.1038/srep37507, PubMed 27897190

Publications 2015

  1. Haikarainen T, Waaler J, Ignatev A, Nkizinkiko Y, Venkannagari H, Obaji E, Krauss S, Lehtiö L (2015)
    Development and structural analysis of adenosine site binding tankyrase inhibitors
    Bioorg Med Chem Lett, 26 (2), 328-333
    DOI 10.1016/j.bmcl.2015.12.018, PubMed 26706174
  2. Thorvaldsen TE, Pedersen NM, Wenzel EM, Schultz SW, Brech A, Liestøl K, Waaler J, Krauss S, Stenmark H (2015)
    Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes
    Mol Cancer Res, 13 (11), 1487-501
    DOI 10.1158/1541-7786.MCR-15-0125, PubMed 26124443
  3. Zhong L, Ding Y, Bandyopadhyay G, Waaler J, Börgeson E, Smith S, Zhang M, Phillips SA, Mahooti S, Mahata SK, Shao J, Krauss S, Chi NW (2015)
    The PARsylation activity of tankyrase in adipose tissue modulates systemic glucose metabolism in mice
    Diabetologia, 59 (3), 582-91
    DOI 10.1007/s00125-015-3815-1, PubMed 26631215

Publications 2013

  1. Lau T, Chan E, Callow M, Waaler J, Boggs J, Blake RA, Magnuson S, Sambrone A, Schutten M, Firestein R, Machon O, Korinek V, Choo E, Diaz D, Merchant M, Polakis P, Holsworth DD, Krauss S, Costa M (2013)
    A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth
    Cancer Res, 73 (10), 3132-44
    DOI 10.1158/0008-5472.CAN-12-4562, PubMed 23539443
  2. Stratford EW, Daffinrud J, Munthe E, Castro R, Waaler J, Krauss S, Myklebost O (2013)
    The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines
    Cancer Med, 3 (1), 36-46
    DOI 10.1002/cam4.170, PubMed 24403055
  3. Voronkov A, Holsworth DD, Waaler J, Wilson SR, Ekblad B, Perdreau-Dahl H, Dinh H, Drewes G, Hopf C, Morth JP, Krauss S (2013)
    Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitor
    J Med Chem, 56 (7), 3012-23
    DOI 10.1021/jm4000566, PubMed 23473363

Publications 2012

  1. Waaler J, Machon O, Tumova L, Dinh H, Korinek V, Wilson SR, Paulsen JE, Pedersen NM, Eide TJ, Machonova O, Gradl D, Voronkov A, von Kries JP, Krauss S (2012)
    A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice
    Cancer Res, 72 (11), 2822-32
    DOI 10.1158/0008-5472.CAN-11-3336, PubMed 22440753

Publications 2011

  1. Waaler J, Machon O, von Kries JP, Wilson SR, Lundenes E, Wedlich D, Gradl D, Paulsen JE, Machonova O, Dembinski JL, Dinh H, Krauss S (2011)
    Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth
    Cancer Res, 71 (1), 197-205
    DOI 10.1158/0008-5472.CAN-10-1282, PubMed 21199802

 
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