Publications 2022

Brinch SA, Amundsen-Isaksen E, Espada S, Hammarström C, Aizenshtadt A, Olsen PA, Holmen L, Høyem M, Scholz H, Grødeland G, Sowa ST, Galera-Prat A, Lehtiö L, Meerts IATM, Leenders RGG, Wegert A, Krauss S, Waaler J (2022)
The Tankyrase Inhibitor OM-153 Demonstrates Antitumor Efficacy and a Therapeutic Window in Mouse Models
Cancer Res Commun, 2 (4), 233-245
DOI 10.1158/2767-9764.CRC-22-0027, PubMed 36873622

Publications 2021

Mygland L, Brinch SA, Strand MF, Olsen PA, Aizenshtadt A, Lund K, Solberg NT, Lycke M, Thorvaldsen TE, Espada S, Misaghian D, Page CM, Agafonov O, Nygård S, Chi NW, Lin E, Tan J, Yu Y, Costa M, Krauss S, Waaler J (2021)
Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines
iScience, 24 (7), 102807
DOI 10.1016/j.isci.2021.102807, PubMed 34337362

Publications 2017

Espada S, Stavik B, Holm S, Sagen EL, Bjerkeli V, Skjelland M, Dahl TB, Espevik T, Kanse S, Sandset PM, Skretting G, Halvorsen B (2017)
Tissue factor pathway inhibitor attenuates ER stress-induced inflammation in human M2-polarized macrophages
Biochem Biophys Res Commun, 491 (2), 442-448
DOI 10.1016/j.bbrc.2017.07.070, PubMed 28712870

Stavik B, Holm S, Espada S, Iversen N, Sporsheim B, Bjerkeli V, Dahl TB, Sandset PM, Skjelland M, Espevik T, Skretting G, Halvorsen B (2017)
Increased expression of TFPI in human carotid stenosis
Thromb Res, 155, 31-37
DOI 10.1016/j.thromres.2017.04.024, PubMed 28482260

Publications 2016

Stavik B, Espada S, Cui XY, Iversen N, Holm S, Mowinkel MC, Halvorsen B, Skretting G, Sandset PM (2016)
EPAS1/HIF-2 alpha-mediated downregulation of tissue factor pathway inhibitor leads to a pro-thrombotic potential in endothelial cells
Biochim Biophys Acta, 1862 (4), 670-678
DOI 10.1016/j.bbadis.2016.01.017, PubMed 26826018

Publications 2014

Delgado-Buenrostro NL, Medina-Reyes EI, Lastres-Becker I, Freyre-Fonseca V, Ji Z, Hernández-Pando R, Marquina B, Pedraza-Chaverri J, Espada S, Cuadrado A, Chirino YI (2014)
Nrf2 protects the lung against inflammation induced by titanium dioxide nanoparticles: A positive regulator role of Nrf2 on cytokine release
Environ Toxicol, 30 (7), 782-92
DOI 10.1002/tox.21957, PubMed 24615891

McCreath KJ, Espada S, Gálvez BG, Benito M, de Molina A, Sepúlveda P, Cervera AM (2014)
Targeted disruption of the SUCNR1 metabolic receptor leads to dichotomous effects on obesity
Diabetes, 64 (4), 1154-67
DOI 10.2337/db14-0346, PubMed 25352636

Publications 2013

Zúñiga-Toalá A, Medina-Campos ON, Espada S, Cuadrado A, Pedraza-Chaverri J (2013)
Nordihydroguaiaretic acid induces heme oxygenase-1 (HO-1) and cytoprotection in a phosphatidyl inositol 3 kinase (PI3K)-dependent way in renal epithelial (LLC-PK1) cells
Journal of Medicinal Plants Research, 7 (5), 186-190
DOI 10.5897/JMPR, PublikaID 219

Publications 2011

Rojo AI, Medina-Campos ON, Rada P, Zúñiga-Toalá A, López-Gazcón A, Espada S, Pedraza-Chaverri J, Cuadrado A (2011)
Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3
Free Radic Biol Med, 52 (2), 473-87
DOI 10.1016/j.freeradbiomed.2011.11.003, PubMed 22142471

Publications 2010

Espada S, Ortega F, Molina-Jijón E, Rojo AI, Pérez-Sen R, Pedraza-Chaverri J, Miras-Portugal MT, Cuadrado A (2010)
The purinergic P2Y(13) receptor activates the Nrf2/HO-1 axis and protects against oxidative stress-induced neuronal death
Free Radic Biol Med, 49 (3), 416-26
DOI 10.1016/j.freeradbiomed.2010.04.031, PubMed 20447456

Publications 2009

Espada S, Rojo AI, Salinas M, Cuadrado A (2009)
The muscarinic M1 receptor activates Nrf2 through a signaling cascade that involves protein kinase C and inhibition of GSK-3beta: connecting neurotransmission with neuroprotection
J Neurochem, 110 (3), 1107-19
DOI 10.1111/j.1471-4159.2009.06208.x, PubMed 19558456

Publications 2008

Guzmán-Beltrán S, Espada S, Orozco-Ibarra M, Pedraza-Chaverri J, Cuadrado A (2008)
Nordihydroguaiaretic acid activates the antioxidant pathway Nrf2/HO-1 and protects cerebellar granule neurons against oxidative stress
Neurosci Lett, 447 (2-3), 167-71
DOI 10.1016/j.neulet.2008.09.079, PubMed 18852027