Publications by Andreas Brech

126 publications found

Publications 2024

1. Pankiv S, Dahl AK, Aas A, Andersen RL, Brech A, Holland P, Singh S, Bindesbøll C, Simonsen A (2024)
   BEACH domain proteins function as cargo-sorting adaptors in secretory and endocytic pathways
   J Cell Biol, 223 (12)
   DOI 10.1083/jcb.202408173, PubMed 39514288
2. Totland MZ, Knudsen LM, Rasmussen NL, Omori Y, Sørensen V, Elster VCW, Stenersen JM, Larsen M, Jensen CL, Zickfeldt Lade AA, Bruusgaard E, Basing S, Kryeziu K, Brech A, Aasen T, Lothe RA, Leithe E (2024)
   The E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation
   Cell Mol Life Sci, 81 (1), 171
   DOI 10.1007/s00018-024-05165-8, PubMed 38597989
3. Wenzel EM, Pedersen NM, Elfmark LA, Wang L, Kjos I, Stang E, Malerød L, Brech A, Stenmark H, Raiborg C (2024)
   Intercellular transfer of cancer cell invasiveness via endosome-mediated protease shedding
   Nat Commun, 15 (1), 1277
   DOI 10.1038/s41467-024-45558-8, PubMed 38341434

Publications 2023

1. Clement D, Szabo EK, Krokeide SZ, Wiiger MT, Vincenti M, Palacios D, Chang YT, Grimm C, Patel S, Stenmark H, Brech A, Majhi RK, Malmberg KJ (2023)
   The Lysosomal Calcium Channel TRPML1 Maintains Mitochondrial Fitness in NK Cells through Interorganelle Cross-Talk
   J Immunol, 211 (9), 1348-1358
   DOI 10.4049/jimmunol.2300406, PubMed 37737664
2. Hessvik NP, Sagini K, Romero S, Ramirez-Garrastacho M, Rodriguez M, Tutturen AEV, Kvalvaag A, Stang E, Brech A, Sandvig K, Llorente A (2023)
   siRNA screening reveals that SNAP29 contributes to exosome release
   Cell Mol Life Sci, 80 (7), 177
   DOI 10.1007/s00018-023-04822-8, PubMed 37285022
3. Perdreau-Dahl H, Lipsett DB, Frisk M, Kermani F, Carlson CR, Brech A, Shen X, Bergan-Dahl A, Hou Y, Tuomainen T, Tavi P, Jones PP, Lunde M, Wasserstrom JA, Laporte J, Ullrich ND, Christensen G, Morth JP, Louch WE (2023)
   BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes
   Circ Res, 132 (11), e188-e205
   DOI 10.1161/CIRCRESAHA.122.321732, PubMed 37139790
4. Pust S, Brech A, Wegner CS, Stenmark H, Haglund K (2023)
   Vesicle-mediated transport of ALIX and ESCRT-III to the intercellular bridge during cytokinesis
   Cell Mol Life Sci, 80 (8), 235
   DOI 10.1007/s00018-023-04864-y, PubMed 37523003
5. Sandoz PA, Kuhnigk K, Szabo EK, Thunberg S, Erikson E, Sandström N, Verron Q, Brech A, Watzl C, Wagner AK, Alici E, Malmberg KJ, Uhlin M, Önfelt B (2023)
   Modulation of lytic molecules restrain serial killing in γδ T lymphocytes
   Nat Commun, 14 (1), 6035
   DOI 10.1038/s41467-023-41634-7, PubMed 37758698
6. Totland MZ, Omori Y, Sørensen V, Kryeziu K, Aasen T, Brech A, Leithe E (2023)
   Endocytic trafficking of connexins in cancer pathogenesis
   Biochim Biophys Acta Mol Basis Dis, 1869 (7), 166812
   DOI 10.1016/j.bbadis.2023.166812, PubMed 37454772

Publications 2022

1. Espeland K, Kleinauskas A, Juzenas P, Brech A, Darvekar S, Vasovic V, Warloe T, Christensen E, Jahnsen J, Peng Q (2022)
   Photodynamic Effects with 5-Aminolevulinic Acid on Cytokines and Exosomes in Human Peripheral Blood Mononuclear Cells
   Biomedicines, 10 (2)
   DOI 10.3390/biomedicines10020232, PubMed 35203441
2. Garcia-Garcia J, Berge AKM, Overå KS, Larsen KB, Bhujabal Z, Brech A, Abudu YP, Lamark T, Johansen T, Sjøttem E (2022)
   TRIM27 is an autophagy substrate facilitating mitochondria clustering and mitophagy via phosphorylated TBK1
   FEBS J, 290 (4), 1096-1116
   DOI 10.1111/febs.16628, PubMed 36111389
3. Radulovic M, Wenzel EM, Gilani S, Holland LK, Lystad AH, Phuyal S, Olkkonen VM, Brech A, Jäättelä M, Maeda K, Raiborg C, Stenmark H (2022)
   Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair
   EMBO J, 41 (24), e112677
   DOI 10.15252/embj.2022112677, PubMed 36408828

Publications 2021

1. Agudo-Canalejo J, Schultz SW, Chino H, Migliano SM, Saito C, Koyama-Honda I, Stenmark H, Brech A, May AI, Mizushima N, Knorr RL (2021)
   Wetting regulates autophagy of phase-separated compartments and the cytosol
   Nature, 591 (7848), 142-146
   DOI 10.1038/s41586-020-2992-3, PubMed 33473217
2. Khezri R, Holland P, Schoborg TA, Abramovich I, Takáts S, Dillard C, Jain A, O'Farrell F, Schultz SW, Hagopian WM, Quintana EM, Ng R, Katheder NS, Rahman MM, Teles Reis JG, Brech A, Jasper H, Rusan NM, Jahren AH, Gottlieb E, Rusten TE (2021)
   Host autophagy mediates organ wasting and nutrient mobilization for tumor growth
   EMBO J, 40 (18), e107336
   DOI 10.15252/embj.2020107336, PubMed 34309071
3. Ravussin A, Brech A, Tooze SA, Stenmark H (2021)
   The phosphatidylinositol 3-phosphate-binding protein SNX4 controls ATG9A recycling and autophagy
   J Cell Sci, 134 (3)
   DOI 10.1242/jcs.250670, PubMed 33468622
4. Schultz SW, Agudo-Canalejo J, Chino H, Migliano SM, Saito C, Koyama-Honda I, Stenmark H, Brech A, Mizushima N, Knorr RL, May AI (2021)
   Should I bend or should I grow: the mechanisms of droplet-mediated autophagosome formation
   Autophagy, 17 (4), 1046-1048
   DOI 10.1080/15548627.2021.1887548, PubMed 33629888
5. Tan KW, Nähse V, Campsteijn C, Brech A, Schink KO, Stenmark H (2021)
   JIP4 is recruited by the phosphoinositide-binding protein Phafin2 to promote recycling tubules on macropinosomes
   J Cell Sci, 134 (14)
   DOI 10.1242/jcs.258495, PubMed 34109410
6. Valko A, Perez-Pandolfo S, Sorianello E, Brech A, Wappner P, Melani M (2021)
   Adaptation to hypoxia in Drosophila melanogaster requires autophagy
   Autophagy, 18 (4), 909-920
   DOI 10.1080/15548627.2021.1991191, PubMed 34793268
7. Weisheit S, Wegner CS, Ailte I, Radulovic M, Weyergang A, Selbo PK, Brech A (2021)
   Inhibiting autophagy increases the efficacy of low-dose photodynamic therapy
   Biochem Pharmacol, 194, 114837
   DOI 10.1016/j.bcp.2021.114837, PubMed 34780750

Publications 2020

1. Caglayan S, Hashim A, Cieslar-Pobuda A, Jensen V, Behringer S, Talug B, Chu DT, Pecquet C, Rogne M, Brech A, Brorson SH, Nagelhus EA, Hannibal L, Boschi A, Taskén K, Staerk J (2020)
   Optic Atrophy 1 Controls Human Neuronal Development by Preventing Aberrant Nuclear DNA Methylation
   iScience, 23 (6), 101154
   DOI 10.1016/j.isci.2020.101154, PubMed 32450518
2. Jakobi AJ, Huber ST, Mortensen SA, Schultz SW, Palara A, Kuhm T, Shrestha BK, Lamark T, Hagen WJH, Wilmanns M, Johansen T, Brech A, Sachse C (2020)
   Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake
   Nat Commun, 11 (1), 440
   DOI 10.1038/s41467-020-14343-8, PubMed 31974402
3. Laiouar S, Berns N, Brech A, Riechmann V (2020)
   RabX1 Organizes a Late Endosomal Compartment that Forms Tubular Connections to Lysosomes Consistent with a "Kiss and Run" Mechanism
   Curr Biol, 30 (7), 1177-1188.e5
   DOI 10.1016/j.cub.2020.01.048, PubMed 32059769
4. Liese S, Wenzel EM, Kjos I, Rojas Molina R, Schultz SW, Brech A, Stenmark H, Raiborg C, Carlson A (2020)
   Protein crowding mediates membrane remodeling in upstream ESCRT-induced formation of intraluminal vesicles
   Proc Natl Acad Sci U S A, 117 (46), 28614-28624
   DOI 10.1073/pnas.2014228117, PubMed 33139578
5. Vietri M, Schultz SW, Bellanger A, Jones CM, Petersen LI, Raiborg C, Skarpen E, Pedurupillay CRJ, Kjos I, Kip E, Timmer R, Jain A, Collas P, Knorr RL, Grellscheid SN, Kusumaatmaja H, Brech A, Micci F, Stenmark H, Campsteijn C (2020)
   Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation
   Nat Cell Biol, 22 (7), 856-867
   DOI 10.1038/s41556-020-0537-5, PubMed 32601372

Publications 2019

1. Goodridge JP, Jacobs B, Saetersmoen ML, Clement D, Hammer Q, Clancy T, Skarpen E, Brech A, Landskron J, Grimm C, Pfefferle A, Meza-Zepeda L, Lorenz S, Wiiger MT, Louch WE, Ask EH, Liu LL, Oei VYS, Kjällquist U, Linnarsson S, Patel S, Taskén K, Stenmark H, Malmberg KJ (2019)
   Remodeling of secretory lysosomes during education tunes functional potential in NK cells
   Nat Commun, 10 (1), 514
   DOI 10.1038/s41467-019-08384-x, PubMed 30705279
2. Hoem G, Bowitz Larsen K, Øvervatn A, Brech A, Lamark T, Sjøttem E, Johansen T (2019)
   The FMRpolyGlycine Protein Mediates Aggregate Formation and Toxicity Independent of the CGG mRNA Hairpin in a Cellular Model for FXTAS
   Front Genet, 10, 249
   DOI 10.3389/fgene.2019.00249, PubMed 30984240
3. Holdgaard SG, Cianfanelli V, Pupo E, Lambrughi M, Lubas M, Nielsen JC, Eibes S, Maiani E, Harder LM, Wesch N, Foged MM, Maeda K, Nazio F, de la Ballina LR, Dötsch V, Brech A, Frankel LB, Jäättelä M, Locatelli F, Barisic M, Andersen JS, Bekker-Jensen S, Lund AH, Rogov VV, Papaleo E et al. (2019)
   Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites
   Nat Commun, 10 (1), 4176
   DOI 10.1038/s41467-019-12094-9, PubMed 31519908
4. Luhr M, Torgersen ML, Szalai P, Hashim A, Brech A, Staerk J, Engedal N (2019)
   The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress
   J Biol Chem, 294 (20), 8197-8217
   DOI 10.1074/jbc.RA118.002829, PubMed 30926605
5. Zhen Y, Spangenberg H, Munson MJ, Brech A, Schink KO, Tan KW, Sørensen V, Wenzel EM, Radulovic M, Engedal N, Simonsen A, Raiborg C, Stenmark H (2019)
   ESCRT-mediated phagophore sealing during mitophagy
   Autophagy, 16 (5), 826-841
   DOI 10.1080/15548627.2019.1639301, PubMed 31366282

Publications 2018

1. Malerød L, Le Borgne R, Lie-Jensen A, Eikenes ÅH, Brech A, Liestøl K, Stenmark H, Haglund K (2018)
   Centrosomal ALIX regulates mitotic spindle orientation by modulating astral microtubule dynamics
   EMBO J, 37 (13)
   DOI 10.15252/embj.201797741, PubMed 29858227
2. Mejlvang J, Olsvik H, Svenning S, Bruun JA, Abudu YP, Larsen KB, Brech A, Hansen TE, Brenne H, Hansen T, Stenmark H, Johansen T (2018)
   Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy
   J Cell Biol, 217 (10), 3640-3655
   DOI 10.1083/jcb.201711002, PubMed 30018090
3. Norum JH, Skarpen E, Brech A, Kuiper R, Waaler J, Krauss S, Sørlie T (2018)
   The tankyrase inhibitor G007-LK inhibits small intestine LGR5⁺ stem cell proliferation without altering tissue morphology
   Biol Res, 51 (1), 3
   DOI 10.1186/s40659-017-0151-6, PubMed 29316982
4. Olsvik HL, Svenning S, Abudu YP, Brech A, Stenmark H, Johansen T, Mejlvang J (2018)
   Endosomal microautophagy is an integrated part of the autophagic response to amino acid starvation
   Autophagy, 15 (1), 182-183
   DOI 10.1080/15548627.2018.1532265, PubMed 30295124
5. Wenzel EM, Schultz SW, Schink KO, Pedersen NM, Nähse V, Carlson A, Brech A, Stenmark H, Raiborg C (2018)
   Concerted ESCRT and clathrin recruitment waves define the timing and morphology of intraluminal vesicle formation
   Nat Commun, 9 (1), 2932
   DOI 10.1038/s41467-018-05345-8, PubMed 30050131

Publications 2017

1. Ailte I, Lingelem AB, Kvalvaag AS, Kavaliauskiene S, Brech A, Koster G, Dommersnes PG, Bergan J, Skotland T, Sandvig K (2017)
   Exogenous lysophospholipids with large head groups perturb clathrin-mediated endocytosis
   Traffic, 18 (3), 176-191
   DOI 10.1111/tra.12468, PubMed 28067430
2. Katheder NS, Khezri R, O'Farrell F, Schultz SW, Jain A, Rahman MM, Schink KO, Theodossiou TA, Johansen T, Juhász G, Bilder D, Brech A, Stenmark H, Rusten TE (2017)
   Microenvironmental autophagy promotes tumour growth
   Nature, 541 (7637), 417-420
   DOI 10.1038/nature20815, PubMed 28077876
3. Lång A, Eriksson J, Schink KO, Lång E, Blicher P, Połeć A, Brech A, Dalhus B, Bøe SO (2017)
   Visualization of PML nuclear import complexes reveals FG-repeat nucleoporins at cargo retrieval sites
   Nucleus, 8 (4), 404-420
   DOI 10.1080/19491034.2017.1306161, PubMed 28402725
4. O'Farrell F, Lobert VH, Sneeggen M, Jain A, Katheder NS, Wenzel EM, Schultz SW, Tan KW, Brech A, Stenmark H, Rusten TE (2017)
   Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation
   Nat Cell Biol, 19 (12), 1412-1423
   DOI 10.1038/ncb3631, PubMed 29084199
5. Olsen CE, Weyergang A, Edwards VT, Berg K, Brech A, Weisheit S, Høgset A, Selbo PK (2017)
   Development of resistance to photodynamic therapy (PDT) in human breast cancer cells is photosensitizer-dependent: Possible mechanisms and approaches for overcoming PDT-resistance
   Biochem Pharmacol, 144, 63-77
   DOI 10.1016/j.bcp.2017.08.002, PubMed 28784290
6. Totland MZ, Bergsland CH, Fykerud TA, Knudsen LM, Rasmussen NL, Eide PW, Yohannes Z, Sørensen V, Brech A, Lothe RA, Leithe E (2017)
   The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions
   J Cell Sci, 130 (17), 2867-2882
   DOI 10.1242/jcs.202408, PubMed 28733455

Publications 2016

1. Fykerud TA, Knudsen LM, Totland MZ, Sørensen V, Dahal-Koirala S, Lothe RA, Brech A, Leithe E (2016)
   Mitotic cells form actin-based bridges with adjacent cells to provide intercellular communication during rounding
   Cell Cycle, 15 (21), 2943-2957
   DOI 10.1080/15384101.2016.1231280, PubMed 27625181
2. Hessvik NP, Øverbye A, Brech A, Torgersen ML, Jakobsen IS, Sandvig K, Llorente A (2016)
   PIKfyve inhibition increases exosome release and induces secretory autophagy
   Cell Mol Life Sci, 73 (24), 4717-4737
   DOI 10.1007/s00018-016-2309-8, PubMed 27438886
3. Puvirajesinghe TM, Bertucci F, Jain A, Scerbo P, Belotti E, Audebert S, Sebbagh M, Lopez M, Brech A, Finetti P, Charafe-Jauffret E, Chaffanet M, Castellano R, Restouin A, Marchetto S, Collette Y, Gonçalvès A, Macara I, Birnbaum D, Kodjabachian L, Johansen T, Borg JP (2016)
   Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer
   Nat Commun, 7, 10318
   DOI 10.1038/ncomms10318, PubMed 26754771

Publications 2015

1. Eikenes ÅH, Malerød L, Lie-Jensen A, Sem Wegner C, Brech A, Liestøl K, Stenmark H, Haglund K (2015)
   Src64 controls a novel actin network required for proper ring canal formation in the Drosophila male germline
   Development, 142 (23), 4107-18
   DOI 10.1242/dev.124370, PubMed 26628094
2. Raiborg C, Wenzel EM, Pedersen NM, Olsvik H, Schink KO, Schultz SW, Vietri M, Nisi V, Bucci C, Brech A, Johansen T, Stenmark H (2015)
   Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth
   Nature, 520 (7546), 234-8
   DOI 10.1038/nature14359, PubMed 25855459
3. Thorvaldsen TE, Pedersen NM, Wenzel EM, Schultz SW, Brech A, Liestøl K, Waaler J, Krauss S, Stenmark H (2015)
   Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes
   Mol Cancer Res, 13 (11), 1487-501
   DOI 10.1158/1541-7786.MCR-15-0125, PubMed 26124443
4. Vietri M, Schink KO, Campsteijn C, Wegner CS, Schultz SW, Christ L, Thoresen SB, Brech A, Raiborg C, Stenmark H (2015)
   Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing
   Nature, 522 (7555), 231-5
   DOI 10.1038/nature14408, PubMed 26040712

Publications 2014

1. Haugsten EM, Brech A, Liestøl K, Norman JC, Wesche J (2014)
   Photoactivation approaches reveal a role for Rab11 in FGFR4 recycling and signalling
   Traffic, 15 (6), 665-83
   DOI 10.1111/tra.12168, PubMed 24589086
2. Oksvold MP, Kullmann A, Forfang L, Kierulf B, Li M, Brech A, Vlassov AV, Smeland EB, Neurauter A, Pedersen KW (2014)
   Expression of B-cell surface antigens in subpopulations of exosomes released from B-cell lymphoma cells
   Clin Ther, 36 (6), 847-862.e1
   DOI 10.1016/j.clinthera.2014.05.010, PubMed 24952935
3. Phuyal S, Skotland T, Hessvik NP, Simolin H, Øverbye A, Brech A, Parton RG, Ekroos K, Sandvig K, Llorente A (2014)
   The ether lipid precursor hexadecylglycerol stimulates the release and changes the composition of exosomes derived from PC-3 cells
   J Biol Chem, 290 (7), 4225-37
   DOI 10.1074/jbc.M114.593962, PubMed 25519911
4. Rørtveit R, Reiten MR, Lingaas F, Sveri SB, Brech A, Espenes A, Jansen JH (2014)
   Glomerular Collagen V Codeposition and Hepatic Perisinusoidal Collagen III Accumulation in Canine Collagen Type III Glomerulopathy
   Vet Pathol, 52 (6), 1134-41
   DOI 10.1177/0300985814560237, PubMed 25487411
5. Wegner CS, Schink KO, Stenmark H, Brech A (2014)
   Monitoring phosphatidylinositol 3-phosphate in multivesicular endosome biogenesis
   Methods Enzymol, 534, 3-23
   DOI 10.1016/B978-0-12-397926-1.00001-9, PubMed 24359945

Publications 2013

1. Amoasii L, Hnia K, Chicanne G, Brech A, Cowling BS, Müller MM, Schwab Y, Koebel P, Ferry A, Payrastre B, Laporte J (2013)
   Myotubularin and PtdIns3P remodel the sarcoplasmic reticulum in muscle in vivo
   J Cell Sci, 126 (Pt 8), 1806-19
   DOI 10.1242/jcs.118505, PubMed 23444364
2. Eikenes ÅH, Brech A, Stenmark H, Haglund K (2013)
   Spatiotemporal control of Cindr at ring canals during incomplete cytokinesis in the Drosophila male germline
   Dev Biol, 377 (1), 9-20
   DOI 10.1016/j.ydbio.2013.02.021, PubMed 23499247
3. Hämälistö S, Pouwels J, de Franceschi N, Saari M, Ivarsson Y, Zimmermann P, Brech A, Stenmark H, Ivaska J (2013)
   A ZO-1/α5β1-integrin complex regulates cytokinesis downstream of PKCε in NCI-H460 cells plated on fibronectin
   PLoS One, 8 (8), e70696
   DOI 10.1371/journal.pone.0070696, PubMed 23967087
4. Knævelsrud H, Søreng K, Raiborg C, Håberg K, Rasmuson F, Brech A, Liestøl K, Rusten TE, Stenmark H, Neufeld TP, Carlsson SR, Simonsen A (2013)
   Membrane remodeling by the PX-BAR protein SNX18 promotes autophagosome formation
   J Cell Biol, 202 (2), 331-49
   DOI 10.1083/jcb.201205129, PubMed 23878278
5. Shahzidi S, Brech A, Sioud M, Li X, Suo Z, Nesland JM, Peng Q (2013)
   Lamin A/C cleavage by caspase-6 activation is crucial for apoptotic induction by photodynamic therapy with hexaminolevulinate in human B-cell lymphoma cells
   Cancer Lett, 339 (1), 25-32
   DOI 10.1016/j.canlet.2013.07.026, PubMed 23916608
6. Wu X, Chen JY, Brech A, Fang C, Wang J, Helm PJ, Peng Q (2013)
   The use of femto-second lasers to trigger powerful explosions of gold nanorods to destroy cancer cells
   Biomaterials, 34 (26), 6157-62
   DOI 10.1016/j.biomaterials.2013.04.048, PubMed 23706782

Publications 2012

1. Deosaran E, Larsen KB, Hua R, Sargent G, Wang Y, Kim S, Lamark T, Jauregui M, Law K, Lippincott-Schwartz J, Brech A, Johansen T, Kim PK (2012)
   NBR1 acts as an autophagy receptor for peroxisomes
   J Cell Sci, 126 (Pt 4), 939-52
   DOI 10.1242/jcs.114819, PubMed 23239026
2. Fykerud TA, Kjenseth A, Schink KO, Sirnes S, Bruun J, Omori Y, Brech A, Rivedal E, Leithe E (2012)
   Smad ubiquitination regulatory factor-2 controls gap junction intercellular communication by modulating endocytosis and degradation of connexin43
   J Cell Sci, 125 (Pt 17), 3966-76
   DOI 10.1242/jcs.093500, PubMed 22623726
3. Hessvik NP, Phuyal S, Brech A, Sandvig K, Llorente A (2012)
   Profiling of microRNAs in exosomes released from PC-3 prostate cancer cells
   Biochim Biophys Acta, 1819 (11-12), 1154-63
   DOI 10.1016/j.bbagrm.2012.08.016, PubMed 22982408
4. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A et al. (2012)
   Guidelines for the use and interpretation of assays for monitoring autophagy
   Autophagy, 8 (4), 445-544
   DOI 10.4161/auto.19496, PubMed 22966490
5. Oppelt A, Lobert VH, Haglund K, Mackey AM, Rameh LE, Liestøl K, Schink KO, Pedersen NM, Wenzel EM, Haugsten EM, Brech A, Rusten TE, Stenmark H, Wesche J (2012)
   Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration
   EMBO Rep, 14 (1), 57-64
   DOI 10.1038/embor.2012.183, PubMed 23154468
6. Pedersen NM, Raiborg C, Brech A, Skarpen E, Roxrud I, Platta HW, Liestøl K, Stenmark H (2012)
   The PtdIns3P-binding protein Phafin 2 mediates epidermal growth factor receptor degradation by promoting endosome fusion
   Traffic, 13 (11), 1547-63
   DOI 10.1111/j.1600-0854.2012.01400.x, PubMed 22816767

Publications 2011

1. Haugsten EM, Zakrzewska M, Brech A, Pust S, Olsnes S, Sandvig K, Wesche J (2011)
   Clathrin- and dynamin-independent endocytosis of FGFR3--implications for signalling
   PLoS One, 6 (7), e21708
   DOI 10.1371/journal.pone.0021708, PubMed 21779335
2. Malerød L, Pedersen NM, Sem Wegner CE, Lobert VH, Leithe E, Brech A, Rivedal E, Liestøl K, Stenmark H (2011)
   Cargo-dependent degradation of ESCRT-I as a feedback mechanism to modulate endosomal sorting
   Traffic, 12 (9), 1211-26
   DOI 10.1111/j.1600-0854.2011.01220.x, PubMed 21564451
3. Sirnes S, Bruun J, Kolberg M, Kjenseth A, Lind GE, Svindland A, Brech A, Nesbakken A, Lothe RA, Leithe E, Rivedal E (2011)
   Connexin43 acts as a colorectal cancer tumor suppressor and predicts disease outcome
   Int J Cancer, 131 (3), 570-81
   DOI 10.1002/ijc.26392, PubMed 21866551
4. Ugland H, Naderi S, Brech A, Collas P, Blomhoff HK (2011)
   cAMP induces autophagy via a novel pathway involving ERK, cyclin E and Beclin 1
   Autophagy, 7 (10), 1199-211
   DOI 10.4161/auto.7.10.16649, PubMed 21750416
5. Warsame AA, Aasheim HC, Nustad K, Trøen G, Tierens A, Wang V, Randen U, Dong HP, Heim S, Brech A, Delabie J (2011)
   Splenic marginal zone lymphoma with VH1-02 gene rearrangement expresses poly- and self-reactive antibodies with similar reactivity
   Blood, 118 (12), 3331-9
   DOI 10.1182/blood-2011-03-341651, PubMed 21725051

Publications 2010

1. Clausen TH, Lamark T, Isakson P, Finley K, Larsen KB, Brech A, Øvervatn A, Stenmark H, Bjørkøy G, Simonsen A, Johansen T (2010)
   p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy
   Autophagy, 6 (3), 330-44
   DOI 10.4161/auto.6.3.11226, PubMed 20168092
2. Filimonenko M, Isakson P, Finley KD, Anderson M, Jeong H, Melia TJ, Bartlett BJ, Myers KM, Birkeland HC, Lamark T, Krainc D, Brech A, Stenmark H, Simonsen A, Yamamoto A (2010)
   The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy
   Mol Cell, 38 (2), 265-79
   DOI 10.1016/j.molcel.2010.04.007, PubMed 20417604
3. Halaas O, Steigedal M, Haug M, Awuh JA, Ryan L, Brech A, Sato S, Husebye H, Cangelosi GA, Akira S, Strong RK, Espevik T, Flo TH (2010)
   Intracellular Mycobacterium avium intersect transferrin in the Rab11(+) recycling endocytic pathway and avoid lipocalin 2 trafficking to the lysosomal pathway
   J Infect Dis, 201 (5), 783-92
   DOI 10.1086/650493, PubMed 20121435
4. Lobert VH, Brech A, Pedersen NM, Wesche J, Oppelt A, Malerød L, Stenmark H (2010)
   Ubiquitination of alpha 5 beta 1 integrin controls fibroblast migration through lysosomal degradation of fibronectin-integrin complexes
   Dev Cell, 19 (1), 148-59
   DOI 10.1016/j.devcel.2010.06.010, PubMed 20643357
5. Nezis IP, Shravage BV, Sagona AP, Lamark T, Bjørkøy G, Johansen T, Rusten TE, Brech A, Baehrecke EH, Stenmark H (2010)
   Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis
   J Cell Biol, 190 (4), 523-31
   DOI 10.1083/jcb.201002035, PubMed 20713604
6. Pankiv S, Alemu EA, Brech A, Bruun JA, Lamark T, Overvatn A, Bjørkøy G, Johansen T (2010)
   FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport
   J Cell Biol, 188 (2), 253-69
   DOI 10.1083/jcb.200907015, PubMed 20100911
7. Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londoño MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MHH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O et al. (2010)
   CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice
   EMBO J, 29 (14), 2421-32
   DOI 10.1038/emboj.2010.120, PubMed 20551902
8. Stuffers S, Malerød L, Schink KO, Corvera S, Stenmark H, Brech A (2010)
   Time-resolved ultrastructural detection of phosphatidylinositol 3-phosphate
   J Histochem Cytochem, 58 (11), 1025-32
   DOI 10.1369/jhc.2010.955815, PubMed 20713985

Publications 2009

1. Bjørkøy G, Lamark T, Pankiv S, Øvervatn A, Brech A, Johansen T (2009)
   Monitoring autophagic degradation of p62/SQSTM1
   Methods Enzymol, 452, 181-97
   DOI 10.1016/S0076-6879(08)03612-4, PubMed 19200883
2. Brech A, Ahlquist T, Lothe RA, Stenmark H (2009)
   Autophagy in tumour suppression and promotion
   Mol Oncol, 3 (4), 366-75
   DOI 10.1016/j.molonc.2009.05.007, PubMed 19559660
3. Leithe E, Kjenseth A, Sirnes S, Stenmark H, Brech A, Rivedal E (2009)
   Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101
   J Cell Sci, 122 (Pt 21), 3883-93
   DOI 10.1242/jcs.053801, PubMed 19808888
4. Nezis IP, Lamark T, Velentzas AD, Rusten TE, Bjørkøy G, Johansen T, Papassideri IS, Stravopodis DJ, Margaritis LH, Stenmark H, Brech A (2009)
   Cell death during Drosophila melanogaster early oogenesis is mediated through autophagy
   Autophagy, 5 (3), 298-302
   DOI 10.4161/auto.5.3.7454, PubMed 19066465
5. Skånland SS, Wälchli S, Brech A, Sandvig K (2009)
   SNX4 in complex with clathrin and dynein: implications for endosome movement
   PLoS One, 4 (6), e5935
   DOI 10.1371/journal.pone.0005935, PubMed 19529763
6. Stuffers S, Sem Wegner C, Stenmark H, Brech A (2009)
   Multivesicular endosome biogenesis in the absence of ESCRTs
   Traffic, 10 (7), 925-37
   DOI 10.1111/j.1600-0854.2009.00920.x, PubMed 19490536
7. Vaccari T, Rusten TE, Menut L, Nezis IP, Brech A, Stenmark H, Bilder D (2009)
   Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants
   J Cell Sci, 122 (Pt 14), 2413-23
   DOI 10.1242/jcs.046391, PubMed 19571114
8. Wegner CS, Malerød L, Pedersen NM, Progida C, Bakke O, Stenmark H, Brech A (2009)
   Ultrastructural characterization of giant endosomes induced by GTPase-deficient Rab5
   Histochem Cell Biol, 133 (1), 41-55
   DOI 10.1007/s00418-009-0643-8, PubMed 19830447
9. Zheng YT, Shahnazari S, Brech A, Lamark T, Johansen T, Brumell JH (2009)
   The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway
   J Immunol, 183 (9), 5909-16
   DOI 10.4049/jimmunol.0900441, PubMed 19812211

Publications 2008

1. Lindmo K, Brech A, Finley KD, Gaumer S, Contamine D, Rusten TE, Stenmark H (2008)
   The PI 3-kinase regulator Vps15 is required for autophagic clearance of protein aggregates
   Autophagy, 4 (4), 500-6
   DOI 10.4161/auto.5829, PubMed 18326940
2. Morrison HA, Dionne H, Rusten TE, Brech A, Fisher WW, Pfeiffer BD, Celniker SE, Stenmark H, Bilder D (2008)
   Regulation of early endosomal entry by the Drosophila tumor suppressors Rabenosyn and Vps45
   Mol Biol Cell, 19 (10), 4167-76
   DOI 10.1091/mbc.e08-07-0716, PubMed 18685079
3. Nezis IP, Simonsen A, Sagona AP, Finley K, Gaumer S, Contamine D, Rusten TE, Stenmark H, Brech A (2008)
   Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain
   J Cell Biol, 180 (6), 1065-71
   DOI 10.1083/jcb.200711108, PubMed 18347073
4. Stuffers S, Brech A, Stenmark H (2008)
   ESCRT proteins in physiology and disease
   Exp Cell Res, 315 (9), 1619-26
   DOI 10.1016/j.yexcr.2008.10.013, PubMed 19013455

Publications 2007

1. Filimonenko M, Stuffers S, Raiborg C, Yamamoto A, Malerød L, Fisher EM, Isaacs A, Brech A, Stenmark H, Simonsen A (2007)
   Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease
   J Cell Biol, 179 (3), 485-500
   DOI 10.1083/jcb.200702115, PubMed 17984323
2. Malerød L, Stuffers S, Brech A, Stenmark H (2007)
   Vps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradation
   Traffic, 8 (11), 1617-29
   DOI 10.1111/j.1600-0854.2007.00630.x, PubMed 17714434
3. Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Øvervatn A, Bjørkøy G, Johansen T (2007)
   p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
   J Biol Chem, 282 (33), 24131-45
   DOI 10.1074/jbc.M702824200, PubMed 17580304
4. Progida C, Malerød L, Stuffers S, Brech A, Bucci C, Stenmark H (2007)
   RILP is required for the proper morphology and function of late endosomes
   J Cell Sci, 120 (Pt 21), 3729-37
   DOI 10.1242/jcs.017301, PubMed 17959629
5. Rusten TE, Vaccari T, Lindmo K, Rodahl LM, Nezis IP, Sem-Jacobsen C, Wendler F, Vincent JP, Brech A, Bilder D, Stenmark H (2007)
   ESCRTs and Fab1 regulate distinct steps of autophagy
   Curr Biol, 17 (20), 1817-25
   DOI 10.1016/j.cub.2007.09.032, PubMed 17935992
6. Simonsen A, Cumming RC, Brech A, Isakson P, Schubert DR, Finley KD (2007)
   Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
   Autophagy, 4 (2), 176-84
   DOI 10.4161/auto.5269, PubMed 18059160

Publications 2006

1. Bache KG, Stuffers S, Malerød L, Slagsvold T, Raiborg C, Lechardeur D, Wälchli S, Lukacs GL, Brech A, Stenmark H (2006)
   The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor
   Mol Biol Cell, 17 (6), 2513-23
   DOI 10.1091/mbc.e05-10-0915, PubMed 16554368
2. Husebye H, Halaas Ø, Stenmark H, Tunheim G, Sandanger Ø, Bogen B, Brech A, Latz E, Espevik T (2006)
   Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity
   EMBO J, 25 (4), 683-92
   DOI 10.1038/sj.emboj.7600991, PubMed 16467847
3. Leithe E, Brech A, Rivedal E (2006)
   Endocytic processing of connexin43 gap junctions: a morphological study
   Biochem J, 393 (Pt 1), 59-67
   DOI 10.1042/BJ20050674, PubMed 16162097
4. Lindmo K, Simonsen A, Brech A, Finley K, Rusten TE, Stenmark H (2006)
   A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body
   Exp Cell Res, 312 (11), 2018-27
   DOI 10.1016/j.yexcr.2006.03.002, PubMed 16600212
5. Rusten TE, Rodahl LM, Pattni K, Englund C, Samakovlis C, Dove S, Brech A, Stenmark H (2006)
   Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors
   Mol Biol Cell, 17 (9), 3989-4001
   DOI 10.1091/mbc.e06-03-0239, PubMed 16837550
6. Slagsvold T, Marchese A, Brech A, Stenmark H (2006)
   CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4
   EMBO J, 25 (16), 3738-49
   DOI 10.1038/sj.emboj.7601267, PubMed 16888620

Publications 2005

1. Bjørkøy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, Stenmark H, Johansen T (2005)
   p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
   J Cell Biol, 171 (4), 603-14
   DOI 10.1083/jcb.200507002, PubMed 16286508
2. Cabezas A, Bache KG, Brech A, Stenmark H (2005)
   Alix regulates cortical actin and the spatial distribution of endosomes
   J Cell Sci, 118 (Pt 12), 2625-35
   DOI 10.1242/jcs.02382, PubMed 15914539
3. Haugsten EM, Sørensen V, Brech A, Olsnes S, Wesche J (2005)
   Different intracellular trafficking of FGF1 endocytosed by the four homologous FGF receptors
   J Cell Sci, 118 (Pt 17), 3869-81
   DOI 10.1242/jcs.02509, PubMed 16091423

Publications 2004

1. Rusten TE, Lindmo K, Juhász G, Sass M, Seglen PO, Brech A, Stenmark H (2004)
   Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway
   Dev Cell, 7 (2), 179-92
   DOI 10.1016/j.devcel.2004.07.005, PubMed 15296715
2. Simonsen A, Birkeland HC, Gillooly DJ, Mizushima N, Kuma A, Yoshimori T, Slagsvold T, Brech A, Stenmark H (2004)
   Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes
   J Cell Sci, 117 (Pt 18), 4239-51
   DOI 10.1242/jcs.01287, PubMed 15292400
3. Sørensen V, Brech A, Khnykin D, Kolpakova E, Citores L, Olsnes S (2004)
   Deletion mutant of FGFR4 induces onion-like membrane structures in the nucleus
   J Cell Sci, 117 (Pt 9), 1807-19
   DOI 10.1242/jcs.01047, PubMed 15075241

Publications 2003

1. Bache KG, Brech A, Mehlum A, Stenmark H (2003)
   Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes
   J Cell Biol, 162 (3), 435-42
   DOI 10.1083/jcb.200302131, PubMed 12900395
2. Mousavi SA, Brech A, Berg T, Kjeken R (2003)
   Phosphoinositide 3-kinase regulates maturation of lysosomes in rat hepatocytes
   Biochem J, 372 (Pt 3), 861-9
   DOI 10.1042/BJ20021136, PubMed 12646047
3. Nilsen T, Slagsvold T, Skjerpen CS, Brech A, Stenmark H, Olsnes S (2003)
   Peroxisomal targeting as a tool for assaying potein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner
   J Biol Chem, 279 (6), 4794-801
   DOI 10.1074/jbc.M309653200, PubMed 14604990

Publications 2001

1. Kjeken R, Mousavi SA, Brech A, Gjøen T, Berg T (2001)
   Fluid phase endocytosis of [125I]iodixanol in rat liver parenchymal, endothelial and Kupffer cells
   Cell Tissue Res, 304 (2), 221-30
   DOI 10.1007/s004410100348, PubMed 11396716
2. Kjeken R, Mousavi SA, Brech A, Griffiths G, Berg T (2001)
   Wortmannin-sensitive trafficking steps in the endocytic pathway in rat liver endothelial cells
   Biochem J, 357 (Pt 2), 497-503
   DOI 10.1042/0264-6021:3570497, PubMed 11439100
3. Mousavi SA, Kjeken R, Berg TO, Seglen PO, Berg T, Brech A (2001)
   Effects of inhibitors of the vacuolar proton pump on hepatic heterophagy and autophagy
   Biochim Biophys Acta, 1510 (1-2), 243-57
   DOI 10.1016/s0005-2736(00)00354-0, PubMed 11342162

Publications 2000

1. Eliassen TM, Frøystad MK, Dannevig BH, Jankowska M, Brech A, Falk K, Romøren K, Gjøen T (2000)
   Initial events in infectious salmon anemia virus infection: evidence for the requirement of a low-pH step
   J Virol, 74 (1), 218-27
   DOI 10.1128/jvi.74.1.218-227.2000, PubMed 10590109
2. Løvdal T, Andersen E, Brech A, Berg T (2000)
   Fc receptor mediated endocytosis of small soluble immunoglobulin G immune complexes in Kupffer and endothelial cells from rat liver
   J Cell Sci, 113 ( Pt 18), 3255-66
   DOI 10.1242/jcs.113.18.3255, PubMed 10954423

Publications 1999

1. Synnes M, Prydz K, Løvdal T, Brech A, Berg T (1999)
   Fluid phase endocytosis and galactosyl receptor-mediated endocytosis employ different early endosomes
   Biochim Biophys Acta, 1421 (2), 317-28
   DOI 10.1016/s0005-2736(99)00134-0, PubMed 10518701

Publications 1998

1. Brech A, Kjeken R, Synnes M, Berg T, Roos N, Prydz K (1998)
   Endocytosed ricin and asialoorosomucoid follow different intracellular pathways in hepatocytes
   Biochim Biophys Acta, 1373 (1), 195-208
   DOI 10.1016/s0005-2736(98)00104-7, PubMed 9733965
2. Simonsen A, Lippé R, Christoforidis S, Gaullier JM, Brech A, Callaghan J, Toh BH, Murphy C, Zerial M, Stenmark H (1998)
   EEA1 links PI(3)K function to Rab5 regulation of endosome fusion
   Nature, 394 (6692), 494-8
   DOI 10.1038/28879, PubMed 9697774

Publications 1996

1. Berg T, Gudmundsen O, Brech A, Kjeken R, Gjøen T (1996)
   Clathrin-dependent and clathrin-independent endocytosis in liver cells
   Z Gastroenterol, 34 Suppl 3, 92-4
   PubMed 8767476
2. Brech A, Løvdahl T, Kjeken R, Roos N, Berg T (1996)
   Density shift of endocytic vesicles induced by uptake of colloidal gold particles in rat hepatocytes
   Z Gastroenterol, 34 Suppl 3, 79-80
   PubMed 8767471
3. Tjelle TE, Brech A, Juvet LK, Griffiths G, Berg T (1996)
   Isolation and characterization of early endosomes, late endosomes and terminal lysosomes: their role in protein degradation
   J Cell Sci, 109 ( Pt 12), 2905-14
   DOI 10.1242/jcs.109.12.2905, PubMed 9013338

Publications 1995

1. Holen I, Gordon PB, Strømhaug PE, Berg TO, Fengsrud M, Brech A, Roos N, Berg T, Seglen PO (1995)
   Inhibition of asialoglycoprotein endocytosis and degradation in rat hepatocytes by protein phosphatase inhibitors
   Biochem J, 311 ( Pt 1) (Pt 1), 317-26
   DOI 10.1042/bj3110317, PubMed 7575471
2. Kjeken R, Brech A, Løvdal T, Roos N, Berg T (1995)
   Involvement of early and late lysosomes in the degradation of mannosylated ligands by rat liver endothelial cells
   Exp Cell Res, 216 (2), 290-8
   DOI 10.1006/excr.1995.1037, PubMed 7843273

Publications 1993

1. BERG T, BRECH A, KJEKEN R, ROOS N (1993)
   PRELYSOSOMAL DEGRADATION IN RAT-LIVER ENDOTHELIAL-CELLS
   CELLS OF THE HEPATIC SINUSOID, VOL 4, 426-430
2. Brech A, Magnusson S, Stang E, Berg T, Roos N (1993)
   Receptor-mediated endocytosis of ricin in rat liver endothelial cells. An immunocytochemical study
   Eur J Cell Biol, 60 (1), 154-62
   PubMed 8462592