Publications Department. of Tumor Biology

Publications published since 1971 from OUS - Department of Tumor Biology

1416 publications found (only first 1000 shown)

Publications 2024

Akdeniz BC, Frei O, Hagen E, Filiz TT, Karthikeyan S, Pasman J, Jangmo A, Bergstedt J, Shorter JR, Zetterberg R, Meijsen J, Sønderby IE, Buil A, Tesli M, Lu Y, Sullivan P, Andreassen OA, Hovig E (2024)
COSGAP: COntainerized Statistical Genetics Analysis Pipelines
Bioinform Adv, 4 (1), vbae067
DOI 10.1093/bioadv/vbae067, PubMed 38808072
Akdeniz BC, Frei O, Shadrin A, Vetrov D, Kropotov D, Hovig E, Andreassen OA, Dale AM (2024)
Finemap-MiXeR: A variational Bayesian approach for genetic finemapping
PLoS Genet, 20 (8), e1011372
DOI 10.1371/journal.pgen.1011372, PubMed 39146375
Angulo JC, Larrinaga G, Lecumberri D, Iturregui AM, Solano-Iturri JD, Lawrie CH, Armesto M, Dorado JF, Nunes-Xavier CE, Pulido R, Manini C, López JI (2024)
Predicting Survival of Metastatic Clear Cell Renal Cell Cancer Treated with VEGFR-TKI-Based Sequential Therapy
Cancers (Basel), 16 (16)
DOI 10.3390/cancers16162786, PubMed 39199559
Bai B, Wise JF, Vodák D, Nakken S, Sharma A, Blaker YN, Brodtkorb M, Hilden V, Trøen G, Ren W, Lorenz S, Lawrence MS, Myklebost O, Kimby E, Pan-Hammarström Q, Steen CB, Meza-Zepeda LA, Beiske K, Smeland EB, Hovig E, Lingjærde OC, Holte H, Myklebust JH (2024)
Multi-omics profiling of longitudinal samples reveals early genomic changes in follicular lymphoma
Blood Cancer J, 14 (1), 147
DOI 10.1038/s41408-024-01124-5, PubMed 39191762
Bischof K, Cremaschi A, Eroukhmanoff L, Landskron J, Flage-Larsen LL, Gade A, Bjørge L, Urbanucci A, Taskén K (2024)
Patient-derived acellular ascites fluid affects drug responses in ovarian cancer cell lines through the activation of key signalling pathways
Mol Oncol (in press)
DOI 10.1002/1878-0261.13726, PubMed 39245677
Bucher-Johannessen C, Senthakumaran T, Avershina E, Birkeland E, Hoff G, Bemanian V, Tunsjø H, Rounge TB (2024)
Species-level verification of Phascolarctobacterium association with colorectal cancer
mSystems, 9 (10), e0073424
DOI 10.1128/msystems.00734-24, PubMed 39287376
Cavanaugh D, Urbanucci A, Mohamed NE, Tewari AK, Figueiro M, Kyprianou N (2024)
Link between circadian rhythm and benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS)
Prostate, 84 (5), 417-425
DOI 10.1002/pros.24656, PubMed 38193363
Dagenborg VJ, Brudvik KW, Lund-Andersen C, Torgunrud A, Lund-Iversen M, Flatmark K, Larsen SG, Yaqub S (2024)
Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy and Liver Resection is a Treatment Option for Patients With Peritoneal and Liver Metastases From Colorectal Cancer
Ann Surg, 280 (5), 745-752
DOI 10.1097/SLA.0000000000006492, PubMed 39185557
Davidson B, Holth A, Lindemann K, Zahl Eriksson AG, Nilsen TA, Torgunrud A (2024)
Molecular characteristics of tubo-ovarian carcinosarcoma at different anatomic locations
Virchows Arch (in press)
DOI 10.1007/s00428-024-03821-9, PubMed 38733380
Edsjö A, Russnes HG, Lehtiö J, Tamborero D, Hovig E, Stenzinger A, Rosenquist R, PCM4EU consortium (2024)
High-throughput molecular assays for inclusion in personalised oncology trials - State-of-the-art and beyond
J Intern Med, 295 (6), 785-803
DOI 10.1111/joim.13785, PubMed 38698538
Egeland EV, Seip K, Skourti E, Øy GF, Pettersen SJ, Pandya AD, Dahle MA, Haugen MH, Kristian A, Nakken S, Engebraaten O, Mælandsmo GM, Prasmickaite L (2024)
The SRC-family serves as a therapeutic target in triple negative breast cancer with acquired resistance to chemotherapy
Br J Cancer, 131 (10), 1656-1667
DOI 10.1038/s41416-024-02875-5, PubMed 39390250
Ellegaard MR, Ebenesersdóttir SS, Moore KHS, Petersén A, Vågene ÅJ, Bieker VC, Denham SD, Cavalleri GL, Gilbert E, Werge T, Hansen TF, Kockum I, Alfredsson L, Olsson T, Hovig E, Gilbert MTP, Stefánsson K, Stenøien HK, Helgason A, Martin MD (2024)
Corroborating written history with ancient DNA: The case of the Well-man described in an Old Norse saga
iScience, 27 (11), 111076
DOI 10.1016/j.isci.2024.111076, PubMed 39620136
Emaldi M, Alamillo-Maeso P, Rey-Iborra E, Mosteiro L, Lecumberri D, Pulido R, López JI, Nunes-Xavier CE (2024)
A functional role for glycosylated B7-H5/VISTA immune checkpoint protein in metastatic clear cell renal cell carcinoma
iScience, 27 (9), 110587
DOI 10.1016/j.isci.2024.110587, PubMed 39262813
Emaldi M, Rey-Iborra E, Marín Á, Mosteiro L, Lecumberri D, Øyjord T, Roncier N, Mælandsmo GM, Angulo JC, Errarte P, Larrinaga G, Pulido R, López JI, Nunes-Xavier CE (2024)
Impact of B7-H3 expression on metastasis, immune exhaustion and JAK/STAT and PI3K/AKT pathways in clear cell renal cell carcinoma
Oncoimmunology, 13 (1), 2419686
DOI 10.1080/2162402X.2024.2419686, PubMed 39621555
Esperon P, Neffa F, Pavicic W, Spirandelli F, Alvarez K, Mullins MJ, Rossi BM, Góngora E Silva RF, Vaccaro C, Lopéz-Köstner F, Rugeles J, Valle AD, Dominguez-Valentin M (2024)
A comprehensive characterization of the spectrum of MUTYH germline pathogenic variants in Latin America
Fam Cancer, 23 (4), 507-513
DOI 10.1007/s10689-024-00382-3, PubMed 38687439
Fleischer T, Haugen MH, Ankill J, Silwal-Pandit L, Børresen-Dale AL, Hedenfalk I, Hatschek T, Tost J, Engebraaten O, Kristensen VN (2024)
An integrated omics approach highlights how epigenetic events can explain and predict response to neoadjuvant chemotherapy and bevacizumab in breast cancer
Mol Oncol, 18 (8), 2042-2059
DOI 10.1002/1878-0261.13656, PubMed 38671580
Foote JB, Mattox TE, Keeton AB, Chen X, Smith F, Berry KL, Holmes T, Wang J, Huang CH, Ward AB, Mitra AK, Ramirez-Alcantara V, Hardy C, Fleten KG, Flatmark K, Yoon KJ, Sarvesh S, Nagaraju GP, Bandi DSR, Maxuitenko YY, Valiyaveettil J, Carstens JL, Buchsbaum DJ, Yang J, Zhou G et al. (2024)
A Novel Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth in Mouse Models of GI Cancer
bioRxiv
DOI 10.1101/2023.05.17.541233, PubMed 38328254
Guldvik IJ, Ramberg H, Kristensen G, Røder A, Mills IG, Lilleby W, Taskén KA (2024)
Systemic interrogation of immune-oncology-related proteins in patients with locally advanced prostate cancer undergoing androgen deprivation and intensity-modulated radiotherapy
World J Urol, 42 (1), 95
DOI 10.1007/s00345-024-04787-8, PubMed 38386171
Heinrich MC, Jones RL, George S, Gelderblom H, Schöffski P, von Mehren M, Zalcberg JR, Kang YK, Razak AA, Trent J, Attia S, Le Cesne A, Siontis BL, Goldstein D, Boye K, Sanchez C, Steeghs N, Rutkowski P, Druta M, Serrano C, Somaiah N, Chi P, Reichmann W, Sprott K, Achour H et al. (2024)
Ripretinib versus sunitinib in gastrointestinal stromal tumor: ctDNA biomarker analysis of the phase 3 INTRIGUE trial
Nat Med, 30 (2), 498-506
DOI 10.1038/s41591-023-02734-5, PubMed 38182785
Istvan P, Birkeland E, Avershina E, Kværner AS, Bemanian V, Pardini B, Tarallo S, de Vos WM, Rognes T, Berstad P, Rounge TB (2024)
Exploring the gut DNA virome in fecal immunochemical test stool samples reveals associations with lifestyle in a large population-based study
Nat Commun, 15 (1), 1791
DOI 10.1038/s41467-024-46033-0, PubMed 38424056
Ivarsdottir EV, Gudmundsson J, Tragante V, Sveinbjornsson G, Kristmundsdottir S, Stacey SN, Halldorsson GH, Magnusson MI, Oddsson A, Walters GB, Sigurdsson A, Saevarsdottir S, Beyter D, Thorleifsson G, Halldorsson BV, Melsted P, Stefansson H, Jonsdottir I, Sørensen E, Pedersen OB, Erikstrup C, Bøgsted M, Pøhl M, Røder A, Stroomberg HV et al. (2024)
Gene-based burden tests of rare germline variants identify six cancer susceptibility genes
Nat Genet, 56 (11), 2422-2433
DOI 10.1038/s41588-024-01966-6, PubMed 39472694
Kandathil SA, Akhondi A, Kadletz-Wanke L, Heiduschka G, Engedal N, Brkic FF (2024)
The dual role of autophagy in HPV-positive head and neck squamous cell carcinoma: a systematic review
J Cancer Res Clin Oncol, 150 (2), 56
DOI 10.1007/s00432-023-05514-3, PubMed 38291202
Katona BW, Lubinski J, Pal T, Huzarski T, Foulkes WD, Moller P, Eisen A, Randall Armel S, Neuhausen SL, Raj R, Aeilts A, Singer CF, Bordeleau L, Karlan B, Olopade O, Tung N, Zakalik D, Kotsopoulos J, Fruscio R, Eng C, Sun P, Narod SA, Hereditary Breast Cancer Clinical Study Group (2024)
The incidence of pancreatic cancer in women with a BRCA1 or BRCA2 mutation
Cancer (in press)
DOI 10.1002/cncr.35666, PubMed 39611336
Kiviaho A, Eerola SK, Kallio HML, Andersen MK, Hoikka M, Tiihonen AM, Salonen I, Spotbeen X, Giesen A, Parker CTA, Taavitsainen S, Hantula O, Marttinen M, Hermelo I, Ismail M, Midtbust E, Wess M, Devlies W, Sharma A, Krossa S, Häkkinen T, Afyounian E, Vandereyken K, Kint S, Kesseli J et al. (2024)
Single cell and spatial transcriptomics highlight the interaction of club-like cells with immunosuppressive myeloid cells in prostate cancer
Nat Commun, 15 (1), 9949
DOI 10.1038/s41467-024-54364-1, PubMed 39550375
Kotsopoulos J, Gronwald J, Huzarski T, Møller P, Pal T, McCuaig JM, Singer CF, Karlan BY, Aeilts A, Eng C, Eisen A, Bordeleau L, Foulkes WD, Tung N, Couch FJ, Fruscio R, Neuhausen SL, Zakalik D, Cybulski C, Metcalfe K, Olopade OI, Sun P, Lubinski J, Narod SA, Hereditary Breast Cancer Clinical Study Group (2024)
Bilateral Oophorectomy and All-Cause Mortality in Women With BRCA1 and BRCA2 Sequence Variations
JAMA Oncol, 10 (4), 484-492
DOI 10.1001/jamaoncol.2023.6937, PubMed 38421677
Kotsopoulos J, Lubinski J, Huzarski T, Bychkovsky BL, Moller P, Kim RH, Tung N, Eisen A, Foulkes W, Singer CF, Aeilts A, Neuhausen SL, Bordeleau L, Karlan B, Fruscio R, Eng C, Olopade O, Zakalik D, Couch F, Y Cajal TR, Sun P, Gronwald J, Narod SA (2024)
Incidence of endometrial cancer in BRCA mutation carriers
Gynecol Oncol, 189, 148-155
DOI 10.1016/j.ygyno.2024.07.687, PubMed 39173195
Kurganovs NJ, Engedal N (2024)
To eat or not to eat: a critical review on the role of autophagy in prostate carcinogenesis and prostate cancer therapeutics
Front Pharmacol, 15, 1419806
DOI 10.3389/fphar.2024.1419806, PubMed 38910881
Lamsal A, Andersen SB, Johansson I, Desgarnier MD, Wolowczyk C, Engedal N, Vietri M, Bjørkøy G, Giambelluca MS, Pettersen K (2024)
Elucidating the power of arginine restriction: taming type I interferon response in breast cancer via selective autophagy
Cell Commun Signal, 22 (1), 481
DOI 10.1186/s12964-024-01858-6, PubMed 39380098
Lubinski J, Kotsopoulos J, Moller P, Pal T, Eisen A, Peck L, Karlan BY, Aeilts A, Eng C, Bordeleau L, Foulkes WD, Tung N, Couch FJ, Fruscio R, Ramon Y Cajal T, Singer CF, Neuhausen SL, Zakalik D, Cybulski C, Gronwald J, Huzarski T, Stempa K, Dungan J, Cullinane C, Olopade OI et al. (2024)
MRI Surveillance and Breast Cancer Mortality in Women With BRCA1 and BRCA2 Sequence Variations
JAMA Oncol, 10 (4), 493-499
DOI 10.1001/jamaoncol.2023.6944, PubMed 38421676
Lund-Andersen C, Torgunrud A, Kanduri C, Dagenborg VJ, Frøysnes IS, Larsen MM, Davidson B, Larsen SG, Flatmark K (2024)
Novel drug resistance mechanisms and drug targets in BRAF-mutated peritoneal metastasis from colorectal cancer
J Transl Med, 22 (1), 646
DOI 10.1186/s12967-024-05467-2, PubMed 38982444
Mattavelli D, Wichmann G, Smussi D, Paderno A, Plana MS, Mesia RN, Compagnoni M, Medda A, Chiocca S, Calza S, Zhan Y, Rognoni C, Tarricone R, Stucchi E, Lorini L, Gurizzan C, Khelik K, Hovig E, Dietz A, Piazza C, Bossi P (2024)
Is precision medicine the solution to improve organ preservation in laryngeal/hypopharyngeal cancer? A position paper by the Preserve Research Group
Front Oncol, 14, 1433333
DOI 10.3389/fonc.2024.1433333, PubMed 39165689
Møller P, Haupt S, Ahadova A, Kloor M, Sampson JR, Sunde L, Seppälä T, Burn J, Bernstein I, Capella G, Evans DG, Lindblom A, Winship I, Macrae F, Katz L, Laish I, Vainer E, Monahan K, Half E, Horisberger K, da Silva LA, Heuveline V, Therkildsen C, Lautrup C, Klarskov LL et al. (2024)
Incidences of colorectal adenomas and cancers under colonoscopy surveillance suggest an accelerated "Big Bang" pathway to CRC in three of the four Lynch syndromes
Hered Cancer Clin Pract, 22 (1), 6
DOI 10.1186/s13053-024-00279-3, PubMed 38741120
Møller P, Hovig E (2024)
Genetic testing for prevention and treatment of cancer
Tidsskr Nor Laegeforen, 144 (13)
DOI 10.4045/tidsskr.24.0434, PubMed 39498653
Møller P, Seppälä TT, Dominguez-Valentin M, Sampson J (2024)
Commentary on Estimating cancer risk in carriers of Lynch syndrome variants in UK Biobank
J Med Genet (in press)
DOI 10.1136/jmg-2024-110385, PubMed 39375027
Narod SA, Gronwald J, Karlan B, Moller P, Huzarski T, Tung N, Aeilts A, Eisen A, Armel SR, Singer CF, Foulkes WD, Neuhausen SL, Olopade O, Pal T, Fruscio R, Metcalfe K, Raj R, Jacobson M, Sun P, Lubinski J, Kotsopoulos J (2024)
Incidence of peritoneal cancer after oophorectomy among BRCA1 and BRCA2 mutation carriers
J Natl Cancer Inst, 116 (11), 1753-1760
DOI 10.1093/jnci/djae151, PubMed 38937272
Niehusmann P, Leske H, Nygaard V, Russnes HG, Zhao S, Latysheva A, Straume Wiig U, Stankuniene B, Ulvmoen A (2024)
Desmoplastic non-infantile ganglioglioma mimicking diffuse leptomeningeal glioneuronal tumor: precision diagnostics and therapeutic implications
Acta Oncol, 63, 392-394
DOI 10.2340/1651-226X.2024.31720, PubMed 38779936
Nikolski M, Hovig E, Al-Shahrour F, Blomberg N, Scollen S, Valencia A, Saunders G (2024)
Roadmap for a European cancer data management and precision medicine infrastructure
Nat Cancer, 5 (3), 367-372
DOI 10.1038/s43018-023-00717-6, PubMed 38321342
Nunes-Xavier CE (2024)
Editorial: Co-inhibitory immune checkpoint proteins as biomarkers and therapeutic targets in cancer
Transl Oncol, 47, 102005
DOI 10.1016/j.tranon.2024.102005, PubMed 39034056
Patrick-Brown TDJH, Barratt-Due A, Trøseid M, Dyrhol-Riise AM, Nezvalova-Henriksen K, Kåsine T, Aukrust P, Olsen IC, NOR Solidarity consortium (2024)
The effects of remdesivir on long-term symptoms in patients hospitalised for COVID-19: a pre-specified exploratory analysis
Commun Med (Lond), 4 (1), 231
DOI 10.1038/s43856-024-00650-4, PubMed 39533001
Patrick-Brown TDJH, Bourner J, Kali S, Trøseid M, Yazdanpanah Y, Olliaro P, Olsen IC (2024)
Experiences and challenges with the new European Clinical Trials Regulation
Trials, 25 (1), 3
DOI 10.1186/s13063-023-07869-x, PubMed 38167484
Pulido R, López JI, Nunes-Xavier CE (2024)
B7-H3: a robust target for immunotherapy in prostate cancer
Trends Cancer, 10 (7), 584-587
DOI 10.1016/j.trecan.2024.05.003, PubMed 38839545
Ranji P, Jonasson E, Andersson L, Filges S, Luna Santamaría M, Vannas C, Dolatabadi S, Gustafsson A, Myklebost O, Håkansson J, Fagman H, Landberg G, Åman P, Ståhlberg A (2024)
Deciphering the role of FUS::DDIT3 expression and tumor microenvironment in myxoid liposarcoma development
J Transl Med, 22 (1), 389
DOI 10.1186/s12967-024-05211-w, PubMed 38671504
Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Chèneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A (2024)
JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles
Nucleic Acids Res, 52 (D1), D174-D182
DOI 10.1093/nar/gkad1059, PubMed 37962376
Ree AH, Høye E, Esbensen Y, Beitnes AR, Negård A, Bernklev L, Tetlie LK, Fretland ÅA, Hamre HM, Kersten C, Hofsli E, Guren MG, Sorbye H, Nilsen HL, Flatmark K, Meltzer S (2024)
Complete response of metastatic microsatellite-stable BRAF V600E colorectal cancer to first-line oxaliplatin-based chemotherapy and immune checkpoint blockade
Oncoimmunology, 13 (1), 2372886
DOI 10.1080/2162402X.2024.2372886, PubMed 38952672
Ree AH, Šaltytė Benth J, Hamre HM, Kersten C, Hofsli E, Guren MG, Sorbye H, Johansen C, Negård A, Bjørnetrø T, Nilsen HL, Berg JP, Flatmark K, Meltzer S (2024)
First-line oxaliplatin-based chemotherapy and nivolumab for metastatic microsatellite-stable colorectal cancer-the randomised METIMMOX trial
Br J Cancer, 130 (12), 1921-1928
DOI 10.1038/s41416-024-02696-6, PubMed 38664577
Reppe S, Gundersen S, Sandve GK, Wang Y, Andreassen OA, Medina-Gomez C, Rivadeneira F, Utheim TP, Hovig E, Gautvik KM (2024)
Identification of Transcripts with Shared Roles in the Pathogenesis of Postmenopausal Osteoporosis and Cardiovascular Disease
Int J Mol Sci, 25 (10)
DOI 10.3390/ijms25105554, PubMed 38791593
Schiffer PH, Natsidis P, Leite DJ, Robertson HE, Lapraz F, Marlétaz F, Fromm B, Baudry L, Simpson F, Høye E, Zakrzewski AC, Kapli P, Hoff KJ, Müller S, Marbouty M, Marlow H, Copley RR, Koszul R, Sarkies P, Telford MJ (2024)
Insights into early animal evolution from the genome of the xenacoelomorph worm Xenoturbella bocki
Elife, 13
DOI 10.7554/eLife.94948, PubMed 39109482
Soarez J, Vaccaro CA, Dominguez-Valentin M, Pavicic WH (2024)
Editorial: Advances in genetics and molecular diagnosis in colorectal, stomach, and pancreatic cancer vol II
Front Oncol, 14, 1448183
DOI 10.3389/fonc.2024.1448183, PubMed 39050580
Sveen A, Johannessen B, Klokkerud SM, Kraggerud SM, Meza-Zepeda LA, Bjørnslett M, Bischof K, Myklebost O, Taskén K, Skotheim RI, Dørum A, Davidson B, Lothe RA (2024)
Evolutionary mode and timing of dissemination of high-grade serous carcinomas
JCI Insight, 9 (3)
DOI 10.1172/jci.insight.170423, PubMed 38175731
Torices L, Nunes-Xavier CE, Mingo J, Luna S, Erramuzpe A, Cortés JM, Pulido R (2024)
Induction of Translational Readthrough on Protein Tyrosine Phosphatases Targeted by Premature Termination Codon Mutations in Human Disease
Methods Mol Biol, 2743, 1-19
DOI 10.1007/978-1-0716-3569-8_1, PubMed 38147205
Torices L, Nunes-Xavier CE, Pulido R (2024)
Potentiation by Protein Synthesis Inducers of Translational Readthrough of Pathogenic Premature Termination Codons in PTEN Isoforms
Cancers (Basel), 16 (16)
DOI 10.3390/cancers16162836, PubMed 39199607
Valsalakumari R, Pandya AD, Prasmickaite L, Kvalvaag A, Myrann AG, Åslund AKO, Kjos MS, Fontecha-Cuenca C, Haroon HB, Ribeiro ARS, Horejs-Hoeck J, Moghimi SM, Mørch Ý, Skotland T, Sandvig K, Mælandsmo GM, Iversen TG (2024)
Preclinical Efficacy of Cabazitaxel Loaded Poly(2-alkyl cyanoacrylate) Nanoparticle Variants
Int J Nanomedicine, 19, 3009-3029
DOI 10.2147/IJN.S450283, PubMed 38562610
van der Werf-'t Lam AS, Rodriguez-Girondo M, Villasmil M, Tops CM, van Hest L, Gille HJP, Duijkers FAM, Wagner A, Eikenboom E, Letteboer TGW, de Jong MM, Bajwa-Ten Broeke SW, Bleeker F, Gomez Garcia EB, Dominguez-Valentin M, Møller P, Suerink M, Nielsen M (2024)
Delineating genotype and parent-of-origin effect on the phenotype in MSH6-associated Lynch syndrome
Genes Chromosomes Cancer, 63 (5), e23237
DOI 10.1002/gcc.23237, PubMed 38722212
Wiig JN, Dagenborg VJ, Larsen SG (2024)
Ten-year survival and pattern of recurrence in patients with locally recurrent rectal or sigmoid cancer undergoing resection
Colorectal Dis (in press)
DOI 10.1111/codi.17226, PubMed 39635974
Zhou Y, Ray PS, Zhu J, Stein F, Rettel M, Sekaran T, Sahadevan S, Perez-Perri JI, Roth EK, Myklebost O, Meza-Zepeda LA, von Deimling A, Fu C, Brosig AN, Boye K, Nathrath M, Blattmann C, Lehner B, Hentze MW, Kulozik AE (2024)
Systematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma
Nat Commun, 15 (1), 2810
DOI 10.1038/s41467-024-47031-y, PubMed 38561347

Publications 2023

Akdeniz BC, Mattingsdal M, Dominguez-Valentin M, Frei O, Shadrin A, Puustusmaa M, Saar R, Sõber S, Møller P, Andreassen OA, Padrik P, Hovig E (2023)
A Breast Cancer Polygenic Risk Score Is Feasible for Risk Stratification in the Norwegian Population
Cancers (Basel), 15 (16)
DOI 10.3390/cancers15164124, PubMed 37627152
Anzar I, Malone B, Samarakoon P, Vardaxis I, Simovski B, Fontenelle H, Meza-Zepeda LA, Stratford R, Keung EZ, Burgess M, Tawbi HA, Myklebost O, Clancy T (2023)
The interplay between neoantigens and immune cells in sarcomas treated with checkpoint inhibition
Front Immunol, 14, 1226445
DOI 10.3389/fimmu.2023.1226445, PubMed 37799721
Arjona-Sanchez A, Martinez-López A, Moreno-Montilla MT, Mulsow J, Lozano-Lominchar P, Martínez-Torres B, Rau B, Canbay E, Sommariva A, Milione M, Deraco M, Sgarbura O, Torgunrud A, Kepenekian V, Carr NJ, Hoorens A, Delhorme JB, Wernert R, Goere D, Martin-Roman L, Cosyns S, Flatmark K, Davidson B, Khellaf L, Pereira-Perez F et al. (2023)
External multicentre validation of pseudomyxoma peritonei PSOGI-Ki67 classification
Eur J Surg Oncol, 49 (8), 1481-1488
DOI 10.1016/j.ejso.2023.03.206, PubMed 36935222
Ballinger ML, Pattnaik S, Mundra PA, Zaheed M, Rath E, Priestley P, Baber J, Ray-Coquard I, Isambert N, Causeret S, van der Graaf WTA, Puri A, Duffaud F, Le Cesne A, Seddon B, Chandrasekar C, Schiffman JD, Brohl AS, James PA, Kurtz JE, Penel N, Myklebost O, Meza-Zepeda LA, Pickett H, Kansara M et al. (2023)
Heritable defects in telomere and mitotic function selectively predispose to sarcomas
Science, 379 (6629), 253-260
DOI 10.1126/science.abj4784, PubMed 36656928
Billingham L, Brown L, Framke T, Greystoke A, Hovig E, Mathur S, Page P, Pean E, Barjesteh van Waalwijk van Doorn-Khosrovani S, Vonk R, Wissink S, Zander H, Plummer R (2023)
Histology independent drug development - Is this the future for cancer drugs?
Cancer Treat Rev, 123, 102674
DOI 10.1016/j.ctrv.2023.102674, PubMed 38176220
Bucher-Johannessen C, Birkeland EE, Vinberg E, Bemanian V, Hoff G, Berstad P, Rounge TB (2023)
Long-term follow-up of colorectal cancer screening attendees identifies differences in Phascolarctobacterium spp. using 16S rRNA and metagenome sequencing
Front Oncol, 13, 1183039
DOI 10.3389/fonc.2023.1183039, PubMed 37182146
Dominguez-Valentin M, Haupt S, Seppälä TT, Sampson JR, Sunde L, Bernstein I, Jenkins MA, Engel C, Aretz S, Nielsen M, Capella G, Balaguer F, Evans DG, Burn J, Holinski-Feder E, Bertario L, Bonanni B, Lindblom A, Levi Z, Macrae F, Winship I, Plazzer JP, Sijmons R, Laghi L, Della Valle A et al. (2023)
Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment: a report from the prospective Lynch syndrome database
EClinicalMedicine, 58, 101909
DOI 10.1016/j.eclinm.2023.101909, PubMed 37181409
Doutel D, Davidson B, Nitschke Pettersen IK, Torgunrud A (2023)
Molecular characteristics of low-grade serous carcinoma in effusions
Cytopathology, 34 (2), 99-105
DOI 10.1111/cyt.13207, PubMed 36609991
Ellingsen EB, O'Day S, Mezheyeuski A, Gromadka A, Clancy T, Kristedja TS, Milhem M, Zakharia Y (2023)
Clinical Activity of Combined Telomerase Vaccination and Pembrolizumab in Advanced Melanoma: Results from a Phase I Trial
Clin Cancer Res, 29 (16), 3026-3036
DOI 10.1158/1078-0432.CCR-23-0416, PubMed 37378632
Figlioli G, Billaud A, Wang Q, Bolla MK, Dennis J, Lush M, Kvist A, Adank MA, Ahearn TU, Antonenkova NN, Auvinen P, Behrens S, Bermisheva M, Bogdanova NV, Bojesen SE, Bonanni B, Brüning T, Camp NJ, Campbell A, Castelao JE, Cessna MH, Nbcs Collaborators, Czene K, Devilee P, Dörk T et al. (2023)
Spectrum and Frequency of Germline FANCM Protein-Truncating Variants in 44,803 European Female Breast Cancer Cases
Cancers (Basel), 15 (13)
DOI 10.3390/cancers15133313, PubMed 37444426
Getu AA, Tigabu A, Zhou M, Lu J, Fodstad Ø, Tan M (2023)
New frontiers in immune checkpoint B7-H3 (CD276) research and drug development
Mol Cancer, 22 (1), 43
DOI 10.1186/s12943-023-01751-9, PubMed 36859240
Ghannoum S, Fantini D, Zahoor M, Reiterer V, Phuyal S, Leoncio Netto W, Sørensen Ø, Iyer A, Sengupta D, Prasmickaite L, Mælandsmo GM, Köhn-Luque A, Farhan H (2023)
A combined experimental-computational approach uncovers a role for the Golgi matrix protein Giantin in breast cancer progression
PLoS Comput Biol, 19 (4), e1010995
DOI 10.1371/journal.pcbi.1010995, PubMed 37068117
Hanes R, Ayuda-Durán P, Rønneberg L, Nakken S, Hovig E, Zucknick M, Enserink JM (2023)
screenwerk: a modular tool for the design and analysis of drug combination screens
Bioinformatics, 39 (1)
DOI 10.1093/bioinformatics/btac840, PubMed 36573326
Haugen MH, von der Lippe Gythfeldt H, Egeland EV, Svartdal Normann L, Pandya AD, Vedin LL, Juell S, Tenstad E, Øy GF, Kristian A, Marangoni E, Sørlie T, Steffensen K, Maelandsmo GM, Engebraaten O (2023)
Liver X receptors induce antiproliferative effects in basal-like breast cancer
Mol Oncol, 17 (10), 2041-2055
DOI 10.1002/1878-0261.13476, PubMed 37341140
Hodan R, Rodgers-Fouche L, Chittenden A, Dominguez-Valentin M, Ferriss J, Gima L, Hamnvik OR, Idos GE, Kline K, Koeller DR, Long JM, McKenna D, Muller C, Thoman M, Wintner A, Bedrick BS, Collaborative Group of the Americas on Inherited Gastrointestinal Cancer (2023)
Cancer surveillance for transgender and gender diverse patients with Lynch syndrome: a practice resource of the Collaborative Group of the Americas on Inherited Gastrointestinal Cancer
Fam Cancer, 22 (4), 437-448
DOI 10.1007/s10689-023-00341-4, PubMed 37341816
Holme B, Bjørnerud B, Pedersen NM, de la Ballina LR, Wesche J, Haugsten EM (2023)
Automated tracking of cell migration in phase contrast images with CellTraxx
Sci Rep, 13 (1), 22982
DOI 10.1038/s41598-023-50227-9, PubMed 38151514
Hyldbakk A, Fleten KG, Snipstad S, Åslund AKO, Davies CL, Flatmark K, Mørch Y (2023)
Intraperitoneal administration of cabazitaxel-loaded nanoparticles in peritoneal metastasis models
Nanomedicine, 48, 102656
DOI 10.1016/j.nano.2023.102656, PubMed 36646195
Ibrahim EIK, Ellingsen EB, Mangsbo SM, Friberg LE (2023)
Bridging responses to a human telomerase reverse transcriptase-based peptide cancer vaccine candidate in a mechanism-based model
Int Immunopharmacol, 126, 111225
DOI 10.1016/j.intimp.2023.111225, PubMed 37988911
Ito I, Yousef AM, Dickson PN, Naini ZA, White MG, Fleten KG, Flatmark K, Fournier KF, Fowlkes NW, Shen JP (2023)
Antitumor activity of intraperitoneal paclitaxel in orthotopic patient-derived xenograft models of mucinous appendiceal adenocarcinoma
bioRxiv
DOI 10.1101/2023.02.01.526672, PubMed 36993681
Kalyanasundaram S, Lefol Y, Gundersen S, Rognes T, Alsøe L, Nilsen HL, Hovig E, Sandve GK, Domanska D (2023)
hGSuite HyperBrowser: A web-based toolkit for hierarchical metadata-informed analysis of genomic tracks
PLoS One, 18 (7), e0286330
DOI 10.1371/journal.pone.0286330, PubMed 37467208
Knutsen E, Das Sajib S, Fiskaa T, Lorens J, Gudjonsson T, Mælandsmo GM, Johansen SD, Seternes OM, Perander M (2023)
Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypes
Front Oncol, 13, 1249895
DOI 10.3389/fonc.2023.1249895, PubMed 38111531
Lamsal A, Andersen SB, Johansson I, Vietri M, Bokil AA, Kurganovs NJ, Rylander F, Bjørkøy G, Pettersen K, Giambelluca MS (2023)
Opposite and dynamic regulation of the interferon response in metastatic and non-metastatic breast cancer
Cell Commun Signal, 21 (1), 50
DOI 10.1186/s12964-023-01062-y, PubMed 36882786
López JI, Hogan MF, Sutton B, Church SE, Angulo JC, Nunes-Xavier CE (2023)
Distinct spatial landscapes in clear-cell renal cell carcinoma as revealed by whole transcriptome analysis
Immunooncol Technol, 21, 100690
DOI 10.1016/j.iotech.2023.100690, PubMed 38292905
Mo T, Brandal SHB, Geier OM, Engebråten O, Nilsen LB, Kristensen VN, Hole KH, Hompland T, Fleischer T, Seierstad T (2023)
MRI Assessment of Changes in Tumor Vascularization during Neoadjuvant Anti-Angiogenic Treatment in Locally Advanced Breast Cancer Patients
Cancers (Basel), 15 (18)
DOI 10.3390/cancers15184662, PubMed 37760629
Mraz KA, Hodan R, Rodgers-Fouche L, Arora S, Balaguer F, Guillem JG, Jeter JM, Kanth P, Li D, Liska D, Melson J, Perez K, Ricker C, Shirts BH, Vilar E, Katona BW, Dominguez-Valentin M (2023)
Current chemoprevention approaches in Lynch syndrome and Familial adenomatous polyposis: a global clinical practice survey
Front Oncol, 13, 1141810
DOI 10.3389/fonc.2023.1141810, PubMed 37293588
Møller P, Seppälä TT, Ahadova A, Crosbie EJ, Holinski-Feder E, Scott R, Haupt S, Möslein G, Winship I, Broeke SWB, Kohut KE, Ryan N, Bauerfeind P, Thomas LE, Evans DG, Aretz S, Sijmons RH, Half E, Heinimann K, Horisberger K, Monahan K, Engel C, Cavestro GM, Fruscio R, Abu-Freha N et al. (2023)
Dominantly inherited micro-satellite instable cancer - the four Lynch syndromes - an EHTG, PLSD position statement
Hered Cancer Clin Pract, 21 (1), 19
DOI 10.1186/s13053-023-00263-3, PubMed 37821984
Nakken S, Gundersen S, Bernal FLM, Polychronopoulos D, Hovig E, Wesche J (2023)
Comprehensive interrogation of gene lists from genome-scale cancer screens with oncoEnrichR
Int J Cancer, 153 (10), 1819-1828
DOI 10.1002/ijc.34666, PubMed 37551617
Namløs HM, Khelik K, Nakken S, Vodák D, Hovig E, Myklebost O, Boye K, Meza-Zepeda LA (2023)
Chromosomal instability and a deregulated cell cycle are intrinsic features of high-risk gastrointestinal stromal tumours with a metastatic potential
Mol Oncol, 17 (11), 2432-2450
DOI 10.1002/1878-0261.13514, PubMed 37622176
Normann LS, Haugen MH, Hongisto V, Aure MR, Leivonen SK, Kristensen VN, Tahiri A, Engebraaten O, Sahlberg KK, Mælandsmo GM (2023)
High-throughput screen in vitro identifies dasatinib as a candidate for combinatorial treatment with HER2-targeting drugs in breast cancer
PLoS One, 18 (1), e0280507
DOI 10.1371/journal.pone.0280507, PubMed 36706086
Nunes-Xavier CE, Emaldi M, Mingo J, Øyjord T, Mælandsmo GM, Fodstad Ø, Errarte P, Larrinaga G, Llarena R, López JI, Pulido R (2023)
The expression pattern of pyruvate dehydrogenase kinases predicts prognosis and correlates with immune exhaustion in clear cell renal cell carcinoma
Sci Rep, 13 (1), 7339
DOI 10.1038/s41598-023-34087-x, PubMed 37147361
Nunes-Xavier CE, Emaldi M, Mingo J, Øyjord T, Mælandsmo GM, Fodstad Ø, Errarte P, Larrinaga G, Llarena R, López JI, Pulido R (2023)
Author Correction: The expression pattern of pyruvate dehydrogenase kinases predicts prognosis and correlates with immune exhaustion in clear cell renal cell carcinoma
Sci Rep, 13 (1), 9186
DOI 10.1038/s41598-023-36328-5, PubMed 37280349
Nygaard V, Ree AH, Dagenborg VJ, Børresen-Dale AL, Edwin B, Fretland ÅA, Grzyb K, Haugen MH, Mælandsmo GM, Flatmark K (2023)
A PRRX1 Signature Identifies TIM-3 and VISTA as Potential Immune Checkpoint Targets in a Subgroup of Microsatellite Stable Colorectal Cancer Liver Metastases
Cancer Res Commun, 3 (2), 235-244
DOI 10.1158/2767-9764.CRC-22-0295, PubMed 36968142
Parry MA, Grist E, Mendes L, Dutey-Magni P, Sachdeva A, Brawley C, Murphy L, Proudfoot J, Lall S, Liu Y, Friedrich S, Ismail M, Hoyle A, Ali A, Haran A, Wingate A, Zakka L, Wetterskog D, Amos CL, Atako NB, Wang V, Rush HL, Jones RJ, Leung H, Cross WR et al. (2023)
Clinical testing of transcriptome-wide expression profiles in high-risk localized and metastatic prostate cancer starting androgen deprivation therapy: an ancillary study of the STAMPEDE abiraterone Phase 3 trial
Res Sq
DOI 10.21203/rs.3.rs-2488586/v1, PubMed 36798177
Patrick-Brown TDJH, Mohamed F, Thrower A, Torgunrud A, Cosyns S, Canbay E, Villeneuve L, Flatmark K, Brandl A (2023)
Determining a minimum data set for reporting clinical and radiologic data for pseudomyxoma peritonei
Pleura Peritoneum, 8 (1), 1-9
DOI 10.1515/pp-2022-0200, PubMed 37020469
Pettersen S, Øy GF, Egeland EV, Juell S, Engebråten O, Mælandsmo GM, Prasmickaite L (2023)
Breast cancer patient-derived explant cultures recapitulate in vivo drug responses
Front Oncol, 13, 1040665
DOI 10.3389/fonc.2023.1040665, PubMed 36910663
Połeć A, Ekstrøm PO, Fougner C, Sørlie T, Norum JH (2023)
Rapid assessment of 3-dimensional intra-tumor heterogeneity through cycling temperature capillary electrophoresis
BMC Res Notes, 16 (1), 167
DOI 10.1186/s13104-023-06437-5, PubMed 37568187
Pulido R, Nunes-Xavier CE (2023)
Editorial: Cell and Developmental Signalling in Neuroblastoma
Front Cell Dev Biol, 10, 1126352
DOI 10.3389/fcell.2022.1126352, PubMed 36684434
Rodgers-Fouche L, Arora S, Ricker C, Li D, Farooqi M, Balaguer F, Dominguez-Valentin M, Guillem JG, Kanth P, Liska D, Melson J, Mraz KA, Shirts BH, Vilar E, Katona BW, Hodan R (2023)
Exploring Stakeholders' Perspectives on Implementing Universal Germline Testing for Colorectal Cancer: Findings From a Clinical Practice Survey
JCO Precis Oncol, 7, e2300440
DOI 10.1200/PO.23.00440, PubMed 37897815
Rodríguez-Varela R, Moore KHS, Ebenesersdóttir SS, Kilinc GM, Kjellström A, Papmehl-Dufay L, Alfsdotter C, Berglund B, Alrawi L, Kashuba N, Sobrado V, Lagerholm VK, Gilbert E, Cavalleri GL, Hovig E, Kockum I, Olsson T, Alfredsson L, Hansen TF, Werge T, Munters AR, Bernhardsson C, Skar B, Christophersen A, Turner-Walker G et al. (2023)
The genetic history of Scandinavia from the Roman Iron Age to the present
Cell, 186 (1), 32-46.e19
DOI 10.1016/j.cell.2022.11.024, PubMed 36608656
Severson TM, Zhu Y, Prekovic S, Schuurman K, Nguyen HM, Brown LG, Hakkola S, Kim Y, Kneppers J, Linder S, Stelloo S, Lieftink C, van der Heijden M, Nykter M, van der Noort V, Sanders J, Morris B, Jenster G, van Leenders GJ, Pomerantz M, Freedman ML, Beijersbergen RL, Urbanucci A, Wessels L, Corey E et al. (2023)
Enhancer profiling identifies epigenetic markers of endocrine resistance and reveals therapeutic options for metastatic castration-resistant prostate cancer patients
medRxiv
DOI 10.1101/2023.02.24.23286403, PubMed 36865297
Solbakken AM, Flatmark K (2023)
ASO Author Reflections: Navigation-Assisted Surgery for Locally Advanced and Recurrent Rectal Cancer: The NAVI-LARRC Trial
Ann Surg Oncol, 30 (12), 7633-7634
DOI 10.1245/s10434-023-14058-2, PubMed 37573284
Solbakken AM, Sellevold S, Spasojevic M, Julsrud L, Emblemsvåg HL, Reims HM, Sørensen O, Thorgersen EB, Fauske L, Ågren JSM, Brennhovd B, Ryder T, Larsen SG, Flatmark K (2023)
Navigation-Assisted Surgery for Locally Advanced Primary and Recurrent Rectal Cancer
Ann Surg Oncol, 30 (12), 7602-7611
DOI 10.1245/s10434-023-13964-9, PubMed 37481493
Tamargo-Gómez I, Martínez-García GG, Suárez MF, Mayoral P, Bretones G, Astudillo A, Prieto-Lloret J, Sveen C, Fueyo A, Engedal N, López-Otín C, Mariño G (2023)
Analysis of ATG4C function in vivo
Autophagy, 19 (11), 2912-2933
DOI 10.1080/15548627.2023.2234799, PubMed 37459465
Thorgersen EB, Solbakken AM, Strøm TK, Goscinski M, Spasojevic M, Larsen SG, Flatmark K (2023)
Short-term results after robot-assisted surgery for primary rectal cancers requiring beyond total mesorectal excision in multiple compartments
Scand J Surg, 113 (1), 3-12
DOI 10.1177/14574969231200654, PubMed 37787437
Torices L, Nunes-Xavier CE, López JI, Pulido R (2023)
Novel anti-PTEN C2 domain monoclonal antibodies to analyse the expression and function of PTEN isoform variants
PLoS One, 18 (8), e0289369
DOI 10.1371/journal.pone.0289369, PubMed 37527256

Publications 2022

Ahadova A, Witt J, Haupt S, Gallon R, Hüneburg R, Nattermann J, Ten Broeke S, Bohaumilitzky L, Hernandez-Sanchez A, Santibanez-Koref M, Jackson MS, Ahtiainen M, Pylvänäinen K, Andini K, Grolmusz VK, Möslein G, Dominguez-Valentin M, Møller P, Fürst D, Sijmons R, Borthwick GM, Burn J, Mecklin JP, Heuveline V, von Knebel Doeberitz M et al. (2022)
Is HLA type a possible cancer risk modifier in Lynch syndrome?
Int J Cancer, 152 (10), 2024-2031
DOI 10.1002/ijc.34312, PubMed 36214792
Alaña L, Nunes-Xavier CE, Zaldumbide L, Martin-Guerrero I, Mosteiro L, Alba-Pavón P, Villate O, García-Obregón S, González-García H, Herraiz R, Astigarraga I, Pulido R, García-Ariza M (2022)
Identification and Functional Analysis of a Novel CTNNB1 Mutation in Pediatric Medulloblastoma
Cancers (Basel), 14 (2)
DOI 10.3390/cancers14020421, PubMed 35053583
Alver TN, Heintz KM, Hovig E, Bøe SL (2022)
Cooperative induction of receptor tyrosine kinases contributes to adaptive MAPK drug resistance in melanoma through the PI3K pathway
Cancer Rep (Hoboken), 6 (2), e1736
DOI 10.1002/cnr2.1736, PubMed 36251678
Ambrosini M, Del Re M, Manca P, Hendifar A, Drilon A, Harada G, Ree AH, Klempner S, Mælandsmo GM, Flatmark K, Russnes HG, Cleary JM, Singh H, Sottotetti E, Martinetti A, Randon G, Sartore-Bianchi A, Capone I, Milione M, Di Bartolomeo M, Pietrantonio F (2022)
ALK Inhibitors in Patients With ALK Fusion-Positive GI Cancers: An International Data Set and a Molecular Case Series
JCO Precis Oncol, 6 (1), e2200015
DOI 10.1200/PO.22.00015, PubMed 35476549
Bjørklund SS, Aure MR, Häkkinen J, Vallon-Christersson J, Kumar S, Evensen KB, Fleischer T, Tost J, OSBREAC, Sahlberg KK, Mathelier A, Bhanot G, Ganesan S, Tekpli X, Kristensen VN (2022)
Subtype and cell type specific expression of lncRNAs provide insight into breast cancer
Commun Biol, 5 (1), 834
DOI 10.1038/s42003-022-03559-7, PubMed 35982125
Cao S, Wang JR, Ji S, Yang P, Dai Y, Guo S, Montierth MD, Shen JP, Zhao X, Chen J, Lee JJ, Guerrero PA, Spetsieris N, Engedal N, Taavitsainen S, Yu K, Livingstone J, Bhandari V, Hubert SM, Daw NC, Futreal PA, Efstathiou E, Lim B, Viale A, Zhang J et al. (2022)
Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression
Nat Biotechnol, 40 (11), 1624-1633
DOI 10.1038/s41587-022-01342-x, PubMed 35697807
Cavestro GM, Mannucci A, Balaguer F, Hampel H, Kupfer SS, Repici A, Sartore-Bianchi A, Seppälä TT, Valentini V, Boland CR, Brand RE, Buffart TE, Burke CA, Caccialanza R, Cannizzaro R, Cascinu S, Cercek A, Crosbie EJ, Danese S, Dekker E, Daca-Alvarez M, Deni F, Dominguez-Valentin M, Eng C, Goel A et al. (2022)
Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines
Clin Gastroenterol Hepatol, 21 (3), 581-603.e33
DOI 10.1016/j.cgh.2022.12.006, PubMed 36549470
Dominguez-Valentin M, Sampson JR, Seppälä TT, Møller P (2022)
Response to Chambuso et al
Genet Med, 24 (5), 1151
DOI 10.1016/j.gim.2022.01.005, PubMed 35216900
Ellingsen EB, Bounova G, Kerzeli I, Anzar I, Simnica D, Aamdal E, Guren T, Clancy T, Mezheyeuski A, Inderberg EM, Mangsbo SM, Binder M, Hovig E, Gaudernack G (2022)
Characterization of the T cell receptor repertoire and melanoma tumor microenvironment upon combined treatment with ipilimumab and hTERT vaccination
J Transl Med, 20 (1), 419
DOI 10.1186/s12967-022-03624-z, PubMed 36089578
Ellingsen EB, Aamdal E, Guren T, Lilleby W, Brunsvig PF, Mangsbo SM, Aamdal S, Hovig E, Mensali N, Gaudernack G, Inderberg EM (2022)
Durable and dynamic hTERT immune responses following vaccination with the long-peptide cancer vaccine UV1: long-term follow-up of three phase I clinical trials
J Immunother Cancer, 10 (5)
DOI 10.1136/jitc-2021-004345, PubMed 35613827
Emaldi M, Nunes-Xavier CE (2022)
B7-H4 Immune Checkpoint Protein Affects Viability and Targeted Therapy of Renal Cancer Cells
Cells, 11 (9)
DOI 10.3390/cells11091448, PubMed 35563753
Engedal N, Proikas-Cezanne T, Albertini MC, Žerovnik E, Lane JD (2022)
Transautophagy: Research and Translation of Autophagy Knowledge 2020
Oxid Med Cell Longev, 2022, 9792132
DOI 10.1155/2022/9792132, PubMed 35340207
Engedal N, Sønstevold T, Beese CJ, Selladurai S, Melcher T, Simensen JE, Frankel LB, Urbanucci A, Torgersen ML (2022)
Measuring Autophagic Cargo Flux with Keima-Based Probes
Methods Mol Biol, 2445, 99-115
DOI 10.1007/978-1-0716-2071-7_7, PubMed 34972988
Fiorito E, Szybowska P, Haugsten EM, Kostas M, Øy GF, Wiedlocha A, Singh S, Nakken S, Mælandsmo GM, Fletcher JA, Meza-Zepeda LA, Wesche J (2022)
Strategies to inhibit FGFR4 V550L-driven rhabdomyosarcoma
Br J Cancer, 127 (11), 1939-1953
DOI 10.1038/s41416-022-01973-6, PubMed 36097178
Fleten KG, Hyldbakk A, Einen C, Benjakul S, Strand BL, Davies CL, Mørch Ý, Flatmark K (2022)
Alginate Microsphere Encapsulation of Drug-Loaded Nanoparticles: A Novel Strategy for Intraperitoneal Drug Delivery
Mar Drugs, 20 (12)
DOI 10.3390/md20120744, PubMed 36547891
Flobak Å, Skånland SS, Hovig E, Taskén K, Russnes HG (2022)
Functional precision cancer medicine: drug sensitivity screening enabled by cell culture models
Trends Pharmacol Sci, 43 (11), 973-985
DOI 10.1016/j.tips.2022.08.009, PubMed 36163057
Fromm B, Høye E, Domanska D, Zhong X, Aparicio-Puerta E, Ovchinnikov V, Umu SU, Chabot PJ, Kang W, Aslanzadeh M, Tarbier M, Mármol-Sánchez E, Urgese G, Johansen M, Hovig E, Hackenberg M, Friedländer MR, Peterson KJ (2022)
MirGeneDB 2.1: toward a complete sampling of all major animal phyla
Nucleic Acids Res, 50 (D1), D204-D210
DOI 10.1093/nar/gkab1101, PubMed 34850127
Fusser M, Øverbye A, Pandya AD, Mørch Ý, Borgos SE, Kildal W, Snipstad S, Sulheim E, Fleten KG, Askautrud HA, Engebraaten O, Flatmark K, Iversen TG, Sandvig K, Skotland T, Mælandsmo GM (2022)
Corrigendum to "Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft", [Journal of Control Release, 293 (2019) 183-192]
J Control Release, 349, 1
DOI 10.1016/j.jconrel.2022.06.040, PubMed 35792388
Georgiesh T, Aggerholm-Pedersen N, Schöffski P, Zhang Y, Napolitano A, Bovée JVMG, Hjelle Å, Tang G, Spalek M, Nannini M, Swanson D, Baad-Hansen T, Sciot R, Hesla AC, Huang P, Dorleijn D, Haugland HK, Lacambra M, Skoczylas J, Pantaleo MA, Haas RL, Meza-Zepeda LA, Haller F, Czarnecka AM, Loong H et al. (2022)
Validation of a novel risk score to predict early and late recurrence in solitary fibrous tumour
Br J Cancer, 127 (10), 1793-1798
DOI 10.1038/s41416-022-01959-4, PubMed 36030294
Giliberto M, Santana LM, Holien T, Misund K, Nakken S, Vodak D, Hovig E, Meza-Zepeda LA, Coward E, Waage A, Taskén K, Skånland SS (2022)
Mutational analysis and protein profiling predict drug sensitivity in multiple myeloma cell lines
Front Oncol, 12, 1040730
DOI 10.3389/fonc.2022.1040730, PubMed 36523963
Gopalakrishnan S, Ebenesersdóttir SS, Lundstrøm IKC, Turner-Walker G, Moore KHS, Luisi P, Margaryan A, Martin MD, Ellegaard MR, Magnússon ÓÞ, Sigurðsson Á, Snorradóttir S, Magnúsdóttir DN, Laffoon JE, van Dorp L, Liu X, Moltke I, Ávila-Arcos MC, Schraiber JG, Rasmussen S, Juan D, Gelabert P, de-Dios T, Fotakis AK, Iraeta-Orbegozo M et al. (2022)
The population genomic legacy of the second plague pandemic
Curr Biol, 32 (21), 4743-4751.e6
DOI 10.1016/j.cub.2022.09.023, PubMed 36182700
Gorunova L, Boye K, Panagopoulos I, Berner JM, Bjerkehagen B, Hompland I, Lobmaier I, Hølmebakk T, Hveem TS, Heim S, Micci F (2022)
Cytogenetic and molecular analyses of 291 gastrointestinal stromal tumors: site-specific cytogenetic evolution as evidence of pathogenetic heterogeneity
Oncotarget, 13, 508-517
DOI 10.18632/oncotarget.28209, PubMed 35284037
Guldvik IJ, Braadland PR, Sivanesan S, Ramberg H, Kristensen G, Tennstedt P, Røder A, Schlomm T, Berge V, Eri LM, Lilleby W, Mills IG, Taskén KA (2022)
Low Blood Levels of LRG1 Before Radical Prostatectomy Identify Patients with High Risk of Progression to Castration-resistant Prostate Cancer
Eur Urol Open Sci, 45, 68-75
DOI 10.1016/j.euros.2022.09.002, PubMed 36353660
Helland Å, Russnes HG, Fagereng GL, Al-Shibli K, Andersson Y, Berg T, Bjørge L, Blix E, Bjerkehagen B, Brabrand S, Cameron MG, Dalhaug A, Dietzel D, Dønnem T, Enerly E, Flobak Å, Fluge S, Gilje B, Gjertsen BT, Grønberg BH, Grønås K, Guren T, Hamre H, Haug Å, Heinrich D et al. (2022)
Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
J Transl Med, 20 (1), 225
DOI 10.1186/s12967-022-03432-5, PubMed 35568909
Helland Å, Russnes HG, Fagereng GL, Al-Shibli K, Andersson Y, Berg T, Bjørge L, Blix E, Bjerkehagen B, Brabrand S, Cameron MG, Dalhaug A, Dietzel D, Dønnem T, Enerly E, Flobak Å, Fluge S, Gilje B, Gjertsen BT, Grønberg BH, Grønås K, Guren T, Hamre H, Haug Å, Heinrich D et al. (2022)
Correction to: Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
J Transl Med, 20 (1), 317
DOI 10.1186/s12967-022-03518-0, PubMed 35841045
Hodan R, Rodgers-Fouche L, Arora S, Dominguez-Valentin M, Kanth P, Katona BW, Mraz KA, Roberts ME, Vilar E, Soto-Azghani CM, Brand RE, Esplin ED, Perez K (2022)
Patterns of germline and somatic testing after universal tumor screening for Lynch syndrome: A clinical practice survey of active members of the Collaborative Group of the Americas on Inherited Gastrointestinal Cancer
J Genet Couns, 31 (4), 949-955
DOI 10.1002/jgc4.1567, PubMed 35218578
Høye E, Dagenborg VJ, Torgunrud A, Lund-Andersen C, Fretland ÅA, Lorenz S, Edwin B, Hovig E, Fromm B, Inderberg EM, Greiff V, Ree AH, Flatmark K (2022)
T cell receptor repertoire sequencing reveals chemotherapy-driven clonal expansion in colorectal liver metastases
Gigascience, 12
DOI 10.1093/gigascience/giad032, PubMed 37161965
Høye E, Fromm B, Böttger PHM, Domanska D, Torgunrud A, Lund-Andersen C, Abrahamsen TW, Fretland ÅA, Dagenborg VJ, Lorenz S, Edwin B, Hovig E, Flatmark K (2022)
A comprehensive framework for analysis of microRNA sequencing data in metastatic colorectal cancer
NAR Cancer, 4 (1), zcab051
DOI 10.1093/narcan/zcab051, PubMed 35047825
Li H, Engel C, Hoya M, Peterlongo P, Yannoukakos D, Livraghi L, Radice P, Thomassen M, Hansen TVO, Gerdes AM, Nielsen HR, Caputo SM, Zambelli A, Borg A, Solano A, Thomas A, Parsons MT, Antoniou AC, Leslie G, Yang X, Chenevix-Trench G, Caldes T, Kwong A, Pedersen IS, Lautrup CK et al. (2022)
Risks of breast and ovarian cancer for women harboring pathogenic missense variants in BRCA1 and BRCA2 compared with those harboring protein truncating variants
Genet Med, 24 (10), 2208
DOI 10.1016/j.gim.2022.08.005, PubMed 36205748
Meltzer S, Negård A, Bakke KM, Hamre HM, Kersten C, Hofsli E, Guren MG, Sorbye H, Flatmark K, Ree AH (2022)
Early radiologic signal of responsiveness to immune checkpoint blockade in microsatellite-stable/mismatch repair-proficient metastatic colorectal cancer
Br J Cancer, 127 (12), 2227-2233
DOI 10.1038/s41416-022-02004-0, PubMed 36229579
Metcalfe KA, Gronwald J, Tung NM, McCuaig JM, Eisen A, Elser C, Foulkes WD, Neuhausen SL, Senter L, Moller P, Bordeleau L, Fruscio R, Velsher L, Zakalik D, Olopade OI, Eng C, Pal T, Cullinane CA, Couch FJ, Kotsopoulos J, Sun P, Lubinski J, Narod SA (2022)
The risks of cancer in older women with BRCA pathogenic variants: How far have we come?
Cancer, 129 (6), 901-907
DOI 10.1002/cncr.34615, PubMed 36571512
Misund K, Hofste Op Bruinink D, Coward E, Hoogenboezem RM, Rustad EH, Sanders MA, Rye M, Sponaas AM, van der Holt B, Zweegman S, Hovig E, Meza-Zepeda LA, Sundan A, Myklebost O, Sonneveld P, Waage A (2022)
Clonal evolution after treatment pressure in multiple myeloma: heterogenous genomic aberrations and transcriptomic convergence
Leukemia, 36 (7), 1887-1897
DOI 10.1038/s41375-022-01597-y, PubMed 35643867
Mo T, Brandal SHB, Köhn-Luque A, Engebraaten O, Kristensen VN, Fleischer T, Hompland T, Seierstad T (2022)
Quantification of Tumor Hypoxia through Unsupervised Modelling of Consumption and Supply Hypoxia MR Imaging in Breast Cancer
Cancers (Basel), 14 (5)
DOI 10.3390/cancers14051326, PubMed 35267636
Møller P (2022)
The Prospective Lynch Syndrome Database: background, design, main results and complete MySQL code
Hered Cancer Clin Pract, 20 (1), 37
DOI 10.1186/s13053-022-00243-z, PubMed 36411472
Møller P, Evans DG (2022)
Inherited Cancer Genetic Epidemiology to Improve Precision Medicine
J Clin Med, 11 (3)
DOI 10.3390/jcm11030879, PubMed 35160330
Møller P, Seppälä T, Dowty JG, Haupt S, Dominguez-Valentin M, Sunde L, Bernstein I, Engel C, Aretz S, Nielsen M, Capella G, Evans DG, Burn J, Holinski-Feder E, Bertario L, Bonanni B, Lindblom A, Levi Z, Macrae F, Winship I, Plazzer JP, Sijmons R, Laghi L, Valle AD, Heinimann K et al. (2022)
Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium
Hered Cancer Clin Pract, 20 (1), 36
DOI 10.1186/s13053-022-00241-1, PubMed 36182917
Namløs HM, Skårn M, Ahmed D, Grad I, Andresen K, Kresse SH, Munthe E, Serra M, Scotlandi K, Llombart-Bosch A, Myklebost O, Lind GE, Meza-Zepeda LA (2022)
miR-486-5p expression is regulated by DNA methylation in osteosarcoma
BMC Genomics, 23 (1), 142
DOI 10.1186/s12864-022-08346-6, PubMed 35172717
Ng MYW, Charsou C, Lapao A, Singh S, Trachsel-Moncho L, Schultz SW, Nakken S, Munson MJ, Simonsen A (2022)
The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics
Nat Commun, 13 (1), 6283
DOI 10.1038/s41467-022-33933-2, PubMed 36270994
Normann LS, Haugen MH, Aure MR, Kristensen VN, Mælandsmo GM, Sahlberg KK (2022)
miR-101-5p Acts as a Tumor Suppressor in HER2-Positive Breast Cancer Cells and Improves Targeted Therapy
Breast Cancer (Dove Med Press), 14, 25-39
DOI 10.2147/BCTT.S338404, PubMed 35256859
Nunes-Xavier CE, Emaldi M, Guldvik IJ, Ramberg H, Taskén KA, Mælandsmo GM, Fodstad Ø, Llarena R, Pulido R, López JI (2022)
Correlation of expression of Major Vault Protein with androgen receptor and immune checkpoint protein B7-H3, and with poor prognosis in prostate cancer
Pathol Res Pract, 241, 154243
DOI 10.1016/j.prp.2022.154243, PubMed 36481650
Nunes-Xavier CE, Mingo J, Emaldi M, Flem-Karlsen K, Mælandsmo GM, Fodstad Ø, Llarena R, López JI, Pulido R (2022)
Heterogeneous Expression and Subcellular Localization of Pyruvate Dehydrogenase Complex in Prostate Cancer
Front Oncol, 12, 873516
DOI 10.3389/fonc.2022.873516, PubMed 35692804
Nyakas M, Fleten KG, Haugen MH, Engedal N, Sveen C, Farstad IN, Flørenes VA, Prasmickaite L, Mælandsmo GM, Seip K (2022)
AXL inhibition improves BRAF-targeted treatment in melanoma
Sci Rep, 12 (1), 5076
DOI 10.1038/s41598-022-09078-z, PubMed 35332208
Pinto R, Hauge T, Jeanmougin M, Pharo HD, Kresse SH, Honne H, Winge SB, Five MB, Kumar T, Mala T, Hauge T, Johnson E, Lind GE (2022)
Targeted genetic and epigenetic profiling of esophageal adenocarcinomas and non-dysplastic Barrett's esophagus
Clin Epigenetics, 14 (1), 77
DOI 10.1186/s13148-022-01287-7, PubMed 35701814
Pulido R, Nunes-Xavier CE (2022)
Hopes on immunotherapy targeting B7-H3 in neuroblastoma
Transl Oncol, 27, 101580
DOI 10.1016/j.tranon.2022.101580, PubMed 36327699
Ree AH, Mælandsmo GM, Flatmark K, Russnes HG, Gómez Castañeda M, Aas E (2022)
Cost-effectiveness of molecularly matched off-label therapies for end-stage cancer - the MetAction precision medicine study
Acta Oncol, 61 (8), 955-962
DOI 10.1080/0284186X.2022.2098053, PubMed 35943168
Sivanesan S, Taskén KA, Grytli HH (2022)
Association of β-Blocker Use at Time of Radical Prostatectomy With Rate of Treatment for Prostate Cancer Recurrence
JAMA Netw Open, 5 (1), e2145230
DOI 10.1001/jamanetworkopen.2021.45230, PubMed 35080602
Sohlberg E, Pfefferle A, Heggernes Ask E, Tschan-Plessl A, Jacobs B, Netskar H, Lorenz S, Kanaya M, Kosugi-Kanaya M, Meinke S, Mörtberg A, Höglund P, Sundin M, Carlsson G, Palmblad J, Malmberg KJ (2022)
Perturbed NK-cell homeostasis associated with disease severity in chronic neutropenia
Blood, 139 (5), 704-716
DOI 10.1182/blood.2021013233, PubMed 34699594
Stacchiotti S, Dürr HR, Schaefer IM, Woertler K, Haas R, Trama A, Caraceni A, Bajpai J, Baldi GG, Bernthal N, Blay JY, Boye K, Broto JM, Chen WT, Dei Tos PA, Desai J, Emhofer S, Eriksson M, Gronchi A, Gelderblom H, Hardes J, Hartmann W, Healey J, Italiano A, Jones RL et al. (2022)
Best clinical management of tenosynovial giant cell tumour (TGCT): A consensus paper from the community of experts
Cancer Treat Rev, 112, 102491
DOI 10.1016/j.ctrv.2022.102491, PubMed 36502615
Søreng K, Pankiv S, Bergsmark C, Haugsten EM, Dahl AK, de la Ballina LR, Yamamoto A, Lystad AH, Simonsen A (2022)
ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration
J Cell Sci, 135 (4)
DOI 10.1242/jcs.259138, PubMed 35099014
Taskén K, Russnes HEG, Aas E, Bjørge L, Blix ES, CONNECT Public–Private Partnership Consortium, Enerly E, Fagereng GL, Flobak Å, Gilje B, Gjertsen BT, Guren TK, Heix J, Hovig E, Hovland R, InPreD-Norway and National Molecular Tumor Board Consortium, IMPRESS-Norway Consortium, Lønning PE, Meza-Zepeda LA, Mæhle PM, Nilsen HL, Thoresen SØ, Widerberg K, Smeland S, Helland Å (2022)
A national precision cancer medicine implementation initiative for Norway
Nat Med, 28 (5), 885-887
DOI 10.1038/s41591-022-01777-4, PubMed 35513529
Tellez-Gabriel M, Tekpli X, Reine TM, Hegge B, Nielsen SR, Chen M, Moi L, Normann LS, Busund LR, Calin GA, Mælandsmo GM, Perander M, Theocharis AD, Kolset SO, Knutsen E (2022)
Serglycin Is Involved in TGF-β Induced Epithelial-Mesenchymal Transition and Is Highly Expressed by Immune Cells in Breast Cancer Tissue
Front Oncol, 12, 868868
DOI 10.3389/fonc.2022.868868, PubMed 35494005
Thomassen M, Mesman RLS, Hansen TVO, Menendez M, Rossing M, Esteban-Sánchez A, Tudini E, Törngren T, Parsons MT, Pedersen IS, Teo SH, Kruse TA, Møller P, Borg Å, Jensen UB, Christensen LL, Singer CF, Muhr D, Santamarina M, Brandao R, Andresen BS, Feng BJ, Canson D, Richardson ME, Karam R et al. (2022)
Clinical, splicing, and functional analysis to classify BRCA2 exon 3 variants: Application of a points-based ACMG/AMP approach
Hum Mutat, 43 (12), 1921-1944
DOI 10.1002/humu.24449, PubMed 35979650
Torices L, Mingo J, Rodríguez-Escudero I, Fernández-Acero T, Luna S, Nunes-Xavier CE, López JI, Mercadillo F, Currás M, Urioste M, Molina M, Cid VJ, Pulido R (2022)
Functional analysis of PTEN variants of unknown significance from PHTS patients unveils complex patterns of PTEN biological activity in disease
Eur J Hum Genet, 31 (5), 568-577
DOI 10.1038/s41431-022-01265-w, PubMed 36543932
Vaccaro CA, Soarez J, Dominguez-Valentin M, Pavicic WH (2022)
Editorial: Advances in genetics and molecular diagnosis in colorectal, stomach, and pancreatic cancer
Front Oncol, 12, 1104671
DOI 10.3389/fonc.2022.1104671, PubMed 36601476
Venizelos A, Engebrethsen C, Deng W, Geisler J, Geisler S, Iversen GT, Aas T, Aase HS, Seyedzadeh M, Steinskog ES, Myklebost O, Nakken S, Vodak D, Hovig E, Meza-Zepeda LA, Lønning PE, Knappskog S, Eikesdal HP (2022)
Clonal evolution in primary breast cancers under sequential epirubicin and docetaxel monotherapy
Genome Med, 14 (1), 86
DOI 10.1186/s13073-022-01090-2, PubMed 35948919
Xia YY, Gronwald J, Karlan B, Lubinski J, McCuaig JM, Brooks J, Moller P, Eisen A, Sun S, Senter L, Bordeleau L, Neuhausen SL, Singer CF, Tung N, Foulkes WD, Sun P, Narod SA, Kotsopoulos J, Hereditary Ovarian Cancer Clinical Study Group (2022)
Contraceptive use and the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation
Gynecol Oncol, 164 (3), 514-521
DOI 10.1016/j.ygyno.2022.01.014, PubMed 35063280
Zavaleta E, Solis N, Palacios MI, Zevallos-Escobar LE, Corales EV, Bazo-Alvarez JC, Dominguez-Barrera C, Campos A, Wernhoff P, Ekstrøm PO, Møller P, Visnovska T, Hovig E, Balazar-Palacios J, Alvarez-Valenzuela K, Nakken S, Dominguez-Valentin M (2022)
Genetic Characterization in High-Risk Individuals from a Low-Resource City of Peru
Cancers (Basel), 14 (22)
DOI 10.3390/cancers14225603, PubMed 36428697

Publications 2021

Andersson Y, Fleten KG, Abrahamsen TW, Reed W, Davidson B, Flatmark K (2021)
Anti-Angiogenic Treatment in Pseudomyxoma Peritonei-Still a Strong Preclinical Rationale
Cancers (Basel), 13 (11)
DOI 10.3390/cancers13112819, PubMed 34198773
Barkovskaya A, Goodwin CM, Seip K, Hilmarsdottir B, Pettersen S, Stalnecker C, Engebraaten O, Briem E, Der CJ, Moestue SA, Gudjonsson T, Maelandsmo GM, Prasmickaite L (2021)
Detection of phenotype-specific therapeutic vulnerabilities in breast cells using a CRISPR loss-of-function screen
Mol Oncol, 15 (8), 2026-2045
DOI 10.1002/1878-0261.12951, PubMed 33759347
Baxter JS, Johnson N, Tomczyk K, Gillespie A, Maguire S, Brough R, Fachal L, Michailidou K, Bolla MK, Wang Q, Dennis J, Ahearn TU, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Aronson KJ, Augustinsson A, Becher H, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Bogdanova NV, Bojesen SE et al. (2021)
Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element
Am J Hum Genet, 108 (7), 1190-1203
DOI 10.1016/j.ajhg.2021.05.013, PubMed 34146516
Boye K, Longhi A, Guren T, Lorenz S, Næss S, Pierini M, Taksdal I, Lobmaier I, Cesari M, Paioli A, Løndalen AM, Setola E, Hompland I, Meza-Zepeda LA, Sundby Hall K, Palmerini E (2021)
Pembrolizumab in advanced osteosarcoma: results of a single-arm, open-label, phase 2 trial
Cancer Immunol Immunother, 70 (9), 2617-2624
DOI 10.1007/s00262-021-02876-w, PubMed 33580363
Cangiano M, Grudniewska M, Salji MJ, Nykter M, Jenster G, Urbanucci A, Granchi Z, Janssen B, Hamilton G, Leung HY, Beumer IJ (2021)
Gene Regulation Network Analysis on Human Prostate Orthografts Highlights a Potential Role for the JMJD6 Regulon in Clinical Prostate Cancer
Cancers (Basel), 13 (9)
DOI 10.3390/cancers13092094, PubMed 33925994
Christensen SB, Simonsen HT, Engedal N, Nissen P, Møller JV, Denmeade SR, Isaacs JT (2021)
From Plant to Patient: Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development
Prog Chem Org Nat Prod, 115, 59-114
DOI 10.1007/978-3-030-64853-4_2, PubMed 33797641
Dagenborg VJ, Marshall SE, Grzyb K, Fretland ÅA, Lund-Iversen M, Mælandsmo GM, Ree AH, Edwin B, Yaqub S, Flatmark K (2021)
Low Concordance Between T-Cell Densities in Matched Primary Tumors and Liver Metastases in Microsatellite Stable Colorectal Cancer
Front Oncol, 11, 671629
DOI 10.3389/fonc.2021.671629, PubMed 34178659
Dominguez-Valentin M, Plazzer JP, Sampson JR, Engel C, Aretz S, Jenkins MA, Sunde L, Bernstein I, Capella G, Balaguer F, Macrae F, Winship IM, Thomas H, Evans DG, Burn J, Greenblatt M, de Vos Tot Nederveen Cappel WH, Sijmons RH, Nielsen M, Bertario L, Bonanni B, Tibiletti MG, Cavestro GM, Lindblom A, Valle AD et al. (2021)
No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in MLH1 and MSH2: A Prospective Lynch Syndrome Database Study
J Clin Med, 10 (13)
DOI 10.3390/jcm10132856, PubMed 34203177
Ellingsen EB, Mangsbo SM, Hovig E, Gaudernack G (2021)
Telomerase as a Target for Therapeutic Cancer Vaccines and Considerations for Optimizing Their Clinical Potential
Front Immunol, 12, 682492
DOI 10.3389/fimmu.2021.682492, PubMed 34290704
Engebraaten O, Yau C, Berg K, Borgen E, Garred Ø, Berstad MEB, Fremstedal ASV, DeMichele A, Veer LV', Esserman L, Weyergang A (2021)
RAB5A expression is a predictive biomarker for trastuzumab emtansine in breast cancer
Nat Commun, 12 (1), 6427
DOI 10.1038/s41467-021-26018-z, PubMed 34741021
Erdélyi K, Ditrói T, Johansson HJ, Czikora Á, Balog N, Silwal-Pandit L, Ida T, Olasz J, Hajdú D, Mátrai Z, Csuka O, Uchida K, Tóvári J, Engebraten O, Akaike T, Børresen Dale AL, Kásler M, Lehtiö J, Nagy P (2021)
Reprogrammed transsulfuration promotes basal-like breast tumor progression via realigning cellular cysteine persulfidation
Proc Natl Acad Sci U S A, 118 (45)
DOI 10.1073/pnas.2100050118, PubMed 34737229
Flatmark K, Torgunrud A, Fleten KG, Davidson B, Juul HV, Mensali N, Lund-Andersen C, Inderberg EM (2021)
Peptide vaccine targeting mutated GNAS: a potential novel treatment for pseudomyxoma peritonei
J Immunother Cancer, 9 (10)
DOI 10.1136/jitc-2021-003109, PubMed 34711663
Fleten KG, Eksteen JJ, Mauseth B, Camilio KA, Vasskog T, Sveinbjørnsson B, Rekdal Ø, Mælandsmo GM, Flatmark K (2021)
Oncolytic peptides DTT-205 and DTT-304 induce complete regression and protective immune response in experimental murine colorectal cancer
Sci Rep, 11 (1), 6731
DOI 10.1038/s41598-021-86239-6, PubMed 33762676
Georgiesh T, Namløs HM, Sharma N, Lorenz S, Myklebost O, Bjerkehagen B, Meza-Zepeda LA, Boye K (2021)
Clinical and molecular implications of NAB2-STAT6 fusion variants in solitary fibrous tumour
Pathology, 53 (6), 713-719
DOI 10.1016/j.pathol.2020.11.010, PubMed 33745702
Grad I, Hanes R, Ayuda-Durán P, Kuijjer ML, Enserink JM, Meza-Zepeda LA, Myklebost O (2021)
Discovery of novel candidates for anti-liposarcoma therapies by medium-scale high-throughput drug screening
PLoS One, 16 (3), e0248140
DOI 10.1371/journal.pone.0248140, PubMed 33690666
Guerriero I, Ramberg H, Sagini K, Ramirez-Garrastacho M, Taskén KA, Llorente A (2021)
Implication of β2-adrenergic receptor and miR-196a correlation in neurite outgrowth of LNCaP prostate cancer cells
PLoS One, 16 (6), e0253828
DOI 10.1371/journal.pone.0253828, PubMed 34191854
Guldvik IJ, Ekseth L, Kishan AU, Stensvold A, Inderberg EM, Lilleby W (2021)
Circulating Tumor Cell Persistence Associates with Long-Term Clinical Outcome to a Therapeutic Cancer Vaccine in Prostate Cancer
J Pers Med, 11 (7)
DOI 10.3390/jpm11070605, PubMed 34206815
Gundersen S, Boddu S, Capella-Gutierrez S, Drabløs F, Fernández JM, Kompova R, Taylor K, Titov D, Zerbino D, Hovig E (2021)
Recommendations for the FAIRification of genomic track metadata
F1000Res, 10
DOI 10.12688/f1000research.28449.1, PubMed 34249331
Haugen MH, Lingjærde OC, Hedenfalk I, Garred Ø, Borgen E, Loman N, Hatschek T, Børresen-Dale AL, Naume B, Mills GB, Mælandsmo GM, Engebraaten O (2021)
Protein Signature Predicts Response to Neoadjuvant Treatment With Chemotherapy and Bevacizumab in HER2-Negative Breast Cancers
JCO Precis Oncol, 5
DOI 10.1200/PO.20.00086, PubMed 34036235
Hovda T, Hoff SR, Larsen M, Romundstad L, Sahlberg KK, Hofvind S (2021)
True and Missed Interval Cancer in Organized Mammographic Screening: A Retrospective Review Study of Diagnostic and Prior Screening Mammograms
Acad Radiol, 29 Suppl 1, S180-S191
DOI 10.1016/j.acra.2021.03.022, PubMed 33926794
Hølmebakk T, Boye K (2021)
ASO Author Reflections: How to Identify Patients at Genuinely High Risk of Recurrence from Localized Gastrointestinal Stromal Tumor of the Stomach?
Ann Surg Oncol, 28 (11), 6846-6847
DOI 10.1245/s10434-021-09608-5, PubMed 33687615
Hølmebakk T, Boye K (2021)
Correction to: ASO Author Reflections: How to Identify Patients at Genuinely High Risk of Recurrence from Localized Gastrointestinal Stromal Tumor of the Stomach?
Ann Surg Oncol, 28 (Suppl 3), 873
DOI 10.1245/s10434-021-09939-3, PubMed 33829360
Hølmebakk T, Wiedswang AM, Meza-Zepeda LA, Hompland I, Lobmaier IVK, Berner JM, Stoldt S, Boye K (2021)
Integrating Anatomical, Molecular and Clinical Risk Factors in Gastrointestinal Stromal Tumor of the Stomach
Ann Surg Oncol, 28 (11), 6837-6845
DOI 10.1245/s10434-021-09605-8, PubMed 33651216
Haakensen VD, Nowak AK, Ellingsen EB, Farooqi SJ, Bjaanæs MM, Horndalsveen H, Mcculloch T, Grundberg O, Cedres SM, Helland Å (2021)
NIPU: a randomised, open-label, phase II study evaluating nivolumab and ipilimumab combined with UV1 vaccination as second line treatment in patients with malignant mesothelioma
J Transl Med, 19 (1), 232
DOI 10.1186/s12967-021-02905-3, PubMed 34059094
Kanduri C, Sandve GK, Hovig E, De S, Layer RM (2021)
Editorial: Genomic Colocalization and Enrichment Analyses
Front Genet, 11, 617876
DOI 10.3389/fgene.2020.617876, PubMed 33574832
Kang W, Fromm B, Houben AJ, Høye E, Bezdan D, Arnan C, Thrane K, Asp M, Johnson R, Biryukova I, Friedländer MR (2021)
MapToCleave: High-throughput profiling of microRNA biogenesis in living cells
Cell Rep, 37 (7), 110015
DOI 10.1016/j.celrep.2021.110015, PubMed 34788611
Karvelsson ST, Sigurdsson A, Seip K, Grinde MT, Wang Q, Johannsson F, Mælandsmo GM, Moestue SA, Rolfsson O, Halldorsson S (2021)
EMT-Derived Alterations in Glutamine Metabolism Sensitize Mesenchymal Breast Cells to mTOR Inhibition
Mol Cancer Res, 19 (9), 1546-1558
DOI 10.1158/1541-7786.MCR-20-0962, PubMed 34088869
Karvelsson ST, Wang Q, Hilmarsdottir B, Sigurdsson A, Moestue SA, Mælandsmo GM, Halldorsson S, Gudmundsson S, Rolfsson O (2021)
Argininosuccinate lyase is a metabolic vulnerability in breast development and cancer
NPJ Syst Biol Appl, 7 (1), 36
DOI 10.1038/s41540-021-00195-5, PubMed 34535676
Kim SJ, Lubinski J, Huzarski T, Møller P, Armel S, Karlan BY, Senter L, Eisen A, Foulkes WD, Singer CF, Tung N, Bordeleau L, Neuhausen SL, Olopade OI, Eng C, Weitzel JN, Fruscio R, Narod SA, Kotsopoulos J, Hereditary Ovarian Cancer Clinical Study Group (2021)
Weight Gain and the Risk of Ovarian Cancer in BRCA1 and BRCA2 Mutation Carriers
Cancer Epidemiol Biomarkers Prev, 30 (11), 2038-2043
DOI 10.1158/1055-9965.EPI-21-0296, PubMed 34426412
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM et al. (2021)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹
Autophagy, 17 (1), 1-382
DOI 10.1080/15548627.2020.1797280, PubMed 33634751
Krzyscik MA, Zakrzewska M, Sørensen V, Øy GF, Brunheim S, Haugsten EM, Mælandsmo GM, Wiedlocha A, Otlewski J (2021)
Fibroblast Growth Factor 2 Conjugated with Monomethyl Auristatin E Inhibits Tumor Growth in a Mouse Model
Biomacromolecules, 22 (10), 4169-4180
DOI 10.1021/acs.biomac.1c00662, PubMed 34542998
Kukkonen K, Taavitsainen S, Huhtala L, Uusi-Makela J, Granberg KJ, Nykter M, Urbanucci A (2021)
Chromatin and Epigenetic Dysregulation of Prostate Cancer Development, Progression, and Therapeutic Response
Cancers (Basel), 13 (13)
DOI 10.3390/cancers13133325, PubMed 34283056
Kværner AS, Birkeland E, Bucher-Johannessen C, Vinberg E, Nordby JI, Kangas H, Bemanian V, Ellonen P, Botteri E, Natvig E, Rognes T, Hovig E, Lyle R, Ambur OH, de Vos WM, Bultman S, Hjartåker A, Landberg R, Song M, Blix HS, Ursin G, Randel KR, de Lange T, Hoff G, Holme Ø et al. (2021)
The CRCbiome study: a large prospective cohort study examining the role of lifestyle and the gut microbiome in colorectal cancer screening participants
BMC Cancer, 21 (1), 930
DOI 10.1186/s12885-021-08640-8, PubMed 34407780
Larrinaga G, Calvete-Candenas J, Solano-Iturri JD, Martín AM, Pueyo A, Nunes-Xavier CE, Pulido R, Dorado JF, López JI, Angulo JC (2021)
(Pro)renin Receptor Is a Novel Independent Prognostic Marker in Invasive Urothelial Carcinoma of the Bladder
Cancers (Basel), 13 (22)
DOI 10.3390/cancers13225642, PubMed 34830803
Larsen SG, Goscinski MA, Dueland S, Steigen SE, Hofsli E, Torgunrud A, Lund-Iversen M, Dagenborg VJ, Flatmark K, Sorbye H (2021)
Impact of KRAS, BRAF and microsatellite instability status after cytoreductive surgery and HIPEC in a national cohort of colorectal peritoneal metastasis patients
Br J Cancer, 126 (5), 726-735
DOI 10.1038/s41416-021-01620-6, PubMed 34887523
Lesueur F, Easton DF, Renault AL, Tavtigian SV, Bernstein JL, Kote-Jarai Z, Eeles RA, Plaseska-Karanfia D, Feliubadaló L, Spanish ATM working group, Arun B, Herold N, Versmold B, Schmutzler RK, GC-HBOC, Nguyen-Dumont T, Southey MC, Dorling L, Dunning AM, Ghiorzo P, Dalmasso BS, Cavaciuti E, Le Gal D, Roberts NJ, Dominguez-Valentin M et al. (2021)
First international workshop of the ATM and cancer risk group (4-5 December 2019)
Fam Cancer, 21 (2), 211-227
DOI 10.1007/s10689-021-00248-y, PubMed 34125377
Li H, Engel C, de la Hoya M, Peterlongo P, Yannoukakos D, Livraghi L, Radice P, Thomassen M, Hansen TVO, Gerdes AM, Nielsen HR, Caputo SM, Zambelli A, Borg A, Solano A, Thomas A, Parsons MT, Antoniou AC, Leslie G, Yang X, Chenevix-Trench G, Caldes T, Kwong A, Pedersen IS, Lautrup CK et al. (2021)
Risks of breast and ovarian cancer for women harboring pathogenic missense variants in BRCA1 and BRCA2 compared with those harboring protein truncating variants
Genet Med, 24 (1), 119-129
DOI 10.1016/j.gim.2021.08.016, PubMed 34906479
Luna S, Torices L, Mingo J, Amo L, Rodríguez-Escudero I, Ruiz-Ibarlucea P, Erramuzpe A, Cortés JM, Tejada MI, Molina M, Nunes-Xavier CE, López JI, Cid VJ, Pulido R (2021)
A global analysis of the reconstitution of PTEN function by translational readthrough of PTEN pathogenic premature termination codons
Hum Mutat, 42 (5), 551-566
DOI 10.1002/humu.24186, PubMed 33600059
Lund-Andersen C, Torgunrud A, Fleten KG, Flatmark K (2021)
Omics analyses in peritoneal metastasis-utility in the management of peritoneal metastases from colorectal cancer and pseudomyxoma peritonei: a narrative review
J Gastrointest Oncol, 12 (Suppl 1), S191-S203
DOI 10.21037/jgo-20-136, PubMed 33968437
Mariathasan AB, Boye K, Dueland S, Flatmark K, Larsen SG (2021)
Metastases in locally advanced rectal cancer undergoing curatively intended treatment
Eur J Surg Oncol, 47 (9), 2377-2383
DOI 10.1016/j.ejso.2021.04.023, PubMed 34049768
Mattingsdal M, Ebenesersdóttir SS, Moore KHS, Andreassen OA, Hansen TF, Werge T, Kockum I, Olsson T, Alfredsson L, Helgason A, Stefánsson K, Hovig E (2021)
The genetic structure of Norway
Eur J Hum Genet, 29 (11), 1710-1718
DOI 10.1038/s41431-021-00899-6, PubMed 34002043
Meltzer S, Torgunrud A, Abrahamsson H, Solbakken AM, Flatmark K, Dueland S, Bakke KM, Bousquet PA, Negård A, Johansen C, Lyckander LG, Larsen FO, Schou JV, Redalen KR, Ree AH (2021)
The circulating soluble form of the CD40 costimulatory immune checkpoint receptor and liver metastasis risk in rectal cancer
Br J Cancer, 125 (2), 240-246
DOI 10.1038/s41416-021-01377-y, PubMed 33837301
Moghaddam S, Jalali A, O'Neill A, Murphy L, Gorman L, Reilly AM, Heffernan Á, Lynch T, Power R, O'Malley KJ, Taskèn KA, Berge V, Solhaug VA, Klocker H, Murphy TB, Watson RW (2021)
Integrating Serum Biomarkers into Prediction Models for Biochemical Recurrence Following Radical Prostatectomy
Cancers (Basel), 13 (16)
DOI 10.3390/cancers13164162, PubMed 34439316
Moller P, Sampson JR, Dominguez-Valentin M, Seppala TT (2021)
Towards evidence-based personalised precision medicine for Lynch syndrome
Lancet Oncol., 22 (9), E383
Morra A, Escala-Garcia M, Beesley J, Keeman R, Canisius S, Ahearn TU, Andrulis IL, Anton-Culver H, Arndt V, Auer PL, Augustinsson A, Beane Freeman LE, Becher H, Beckmann MW, Behrens S, Bojesen SE, Bolla MK, Brenner H, Brüning T, Buys SS, Caan B, Campa D, Canzian F, Castelao JE, Chang-Claude J et al. (2021)
Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment
Breast Cancer Res, 23 (1), 86
DOI 10.1186/s13058-021-01450-7, PubMed 34407845
Munson MJ, Mathai BJ, Ng MYW, Trachsel-Moncho L, de la Ballina LR, Schultz SW, Aman Y, Lystad AH, Singh S, Singh S, Wesche J, Fang EF, Simonsen A (2021)
GAK and PRKCD are positive regulators of PRKN-independent mitophagy
Nat Commun, 12 (1), 6101
DOI 10.1038/s41467-021-26331-7, PubMed 34671015
Møller P, Sampson J, Dominguez-Valentin M, Burn J, Sunde L, Möslein G, Mecklin JP, Seppälä T (2021)
Correction to: Letter to the Editor-Recent advances in Lynch syndrome
Fam Cancer, 20 (2), 119
DOI 10.1007/s10689-021-00246-0, PubMed 33792829
Møller P, Sampson JR, Dominguez-Valentin M, Seppälä TT (2021)
Towards evidence-based personalised precision medicine for Lynch syndrome
Lancet Oncol, 22 (9), e383
DOI 10.1016/S1470-2045(21)00400-9, PubMed 34478667
Nakken S, Lilleby W, Switlyk MD, Knudsen KE, Lilleby O, Zhao S, Kaveh F, Ekstrøm PO, Urbanucci A, Hovig E (2021)
The Quandary of DNA-Based Treatment Assessment in De Novo Metastatic Prostate Cancer in the Era of Precision Oncology
J Pers Med, 11 (5)
DOI 10.3390/jpm11050330, PubMed 33922147
Nakken S, Saveliev V, Hofmann O, Møller P, Myklebost O, Hovig E (2021)
Cancer Predisposition Sequencing Reporter (CPSR): A flexible variant report engine for high-throughput germline screening in cancer
Int J Cancer, 149 (11), 1955-1960
DOI 10.1002/ijc.33749, PubMed 34310709
Normann LS, Aure MR, Leivonen SK, Haugen MH, Hongisto V, Kristensen VN, Mælandsmo GM, Sahlberg KK (2021)
MicroRNA in combination with HER2-targeting drugs reduces breast cancer cell viability in vitro
Sci Rep, 11 (1), 10893
DOI 10.1038/s41598-021-90385-2, PubMed 34035375
Nunes-Xavier CE, Kildal W, Kleppe A, Danielsen HE, Waehre H, Llarena R, Maelandsmo GM, Fodstad Ø, Pulido R, López JI (2021)
Immune checkpoint B7-H3 protein expression is associated with poor outcome and androgen receptor status in prostate cancer
Prostate, 81 (12), 838-848
DOI 10.1002/pros.24180, PubMed 34125445
Nunes-Xavier CE, Zaldumbide L, Mosteiro L, López-Almaraz R, García de Andoin N, Aguirre P, Emaldi M, Torices L, López JI, Pulido R (2021)
Protein Tyrosine Phosphatases in Neuroblastoma: Emerging Roles as Biomarkers and Therapeutic Targets
Front Cell Dev Biol, 9, 811297
DOI 10.3389/fcell.2021.811297, PubMed 34957126
Oksvold MP, Berglund UW, Gad H, Bai B, Stokke T, Rein ID, Pham T, Sanjiv K, Øy GF, Norum JH, Smeland EB, Myklebust JH, Helleday T, Våtsveen TK (2021)
Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma
Sci Rep, 11 (1), 6317
DOI 10.1038/s41598-021-85613-8, PubMed 33737576
Pandya AD, Iversen TG, Moestue S, Grinde MT, Mørch Ý, Snipstad S, Åslund AKO, Øy GF, Kildal W, Engebråten O, Sandvig K, Skotland T, Mælandsmo GM (2021)
Biodistribution of Poly(alkyl cyanoacrylate) Nanoparticles in Mice and Effect on Tumor Infiltration of Macrophages into a Patient-Derived Breast Cancer Xenograft
Nanomaterials (Basel), 11 (5)
DOI 10.3390/nano11051140, PubMed 33924869
Park J, Choi JY, Choi J, Chung S, Song N, Park SK, Han W, Noh DY, Ahn SH, Lee JW, Kim MK, Jee SH, Wen W, Bolla MK, Wang Q, Dennis J, Michailidou K, Shah M, Conroy DM, Harrington PA, Mayes R, Czene K, Hall P, Teras LR, Patel AV et al. (2021)
Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer: Can Gene-Environment Interactions Be Detected Only among Candidate SNPs from Genome-Wide Association Studies?
Cancers (Basel), 13 (10)
DOI 10.3390/cancers13102370, PubMed 34069208
Pavlović M, Scheffer L, Motwani K, Kanduri C, Kompova R, Vazov N, Waagan K, Bernal FLM, Costa AA, Corrie B, Akbar R, Al Hajj GS, Balaban G, Brusko TM, Chernigovskaya M, Christley S, Cowell LG, Frank R, Grytten I, Gundersen S, Haff IH, Hovig E, Hsieh PH, Klambauer G, Kuijjer ML et al. (2021)
The immuneML ecosystem for machine learning analysis of adaptive immune receptor repertoires
Nat Mach Intell, 3 (11), 936-944
DOI 10.1038/s42256-021-00413-z, PubMed 37396030
Peneder P, Stütz AM, Surdez D, Krumbholz M, Semper S, Chicard M, Sheffield NC, Pierron G, Lapouble E, Tötzl M, Ergüner B, Barreca D, Rendeiro AF, Agaimy A, Boztug H, Engstler G, Dworzak M, Bernkopf M, Taschner-Mandl S, Ambros IM, Myklebost O, Marec-Bérard P, Burchill SA, Brennan B, Strauss SJ et al. (2021)
Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden
Nat Commun, 12 (1), 3230
DOI 10.1038/s41467-021-23445-w, PubMed 34050156
Ramberg H, Richardsen E, de Souza GA, Rakaee M, Stensland ME, Braadland PR, Nygård S, Ögren O, Guldvik IJ, Berge V, Svindland A, Taskén KA, Andersen S (2021)
Proteomic analyses identify major vault protein as a prognostic biomarker for fatal prostate cancer
Carcinogenesis, 42 (5), 685-693
DOI 10.1093/carcin/bgab015, PubMed 33609362
Ramirez-Garrastacho M, Bajo-Santos C, Line A, Martens-Uzunova ES, de la Fuente JM, Moros M, Soekmadji C, Tasken KA, Llorente A (2021)
Extracellular vesicles as a source of prostate cancer biomarkers in liquid biopsies: a decade of research
Br J Cancer, 126 (3), 331-350
DOI 10.1038/s41416-021-01610-8, PubMed 34811504
Schläfli AM, Tokarchuk I, Parejo S, Jutzi S, Berezowska S, Engedal N, Tschan MP (2021)
ALK inhibition activates LC3B-independent, protective autophagy in EML4-ALK positive lung cancer cells
Sci Rep, 11 (1), 9011
DOI 10.1038/s41598-021-87966-6, PubMed 33907223
Seppälä TT, Dominguez-Valentin M, Crosbie EJ, Engel C, Aretz S, Macrae F, Winship I, Capella G, Thomas H, Hovig E, Nielsen M, Sijmons RH, Bertario L, Bonanni B, Tibiletti MG, Cavestro GM, Mints M, Gluck N, Katz L, Heinimann K, Vaccaro CA, Green K, Lalloo F, Hill J, Schmiegel W et al. (2021)
Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report
Eur J Cancer, 148, 124-133
DOI 10.1016/j.ejca.2021.02.022, PubMed 33743481
Seppälä TT, Latchford A, Negoi I, Sampaio Soares A, Jimenez-Rodriguez R, Sánchez-Guillén L, Evans DG, Ryan N, Crosbie EJ, Dominguez-Valentin M, Burn J, Kloor M, Knebel Doeberitz MV, Duijnhoven FJBV, Quirke P, Sampson JR, Møller P, Möslein G, European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP) (2021)
European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender
Br J Surg, 108 (5), 484-498
DOI 10.1002/bjs.11902, PubMed 34043773
Solis N, Zavaleta E, Wernhoff P, Dominguez-Barrera C, Dominguez-Valentin M (2021)
Challenges to Bringing Personalized Medicine to a Low-Resource Setting in Peru
Int J Environ Res Public Health, 18 (4)
DOI 10.3390/ijerph18041470, PubMed 33557277
Stabell M, Sæther T, Røhr ÅK, Gabrielsen OS, Myklebost O (2021)
Methylation-dependent SUMOylation of the architectural transcription factor HMGA2
Biochem Biophys Res Commun, 552, 91-97
DOI 10.1016/j.bbrc.2021.02.099, PubMed 33744765
Stjepanovic N, Lubinski J, Moller P, Randall Armel S, Foulkes WD, Tung N, Neuhausen SL, Kotsopoulos J, Sun P, Sun S, Eisen A, Narod SA, Hereditary Breast Cancer Clinical Study Group (2021)
Breast cancer risk after age 60 among BRCA1 and BRCA2 mutation carriers
Breast Cancer Res Treat, 187 (2), 515-523
DOI 10.1007/s10549-020-06072-9, PubMed 33423179
Sveen A, Johannessen B, Eilertsen IA, Røsok BI, Gulla M, Eide PW, Bruun J, Kryeziu K, Meza-Zepeda LA, Myklebost O, Bjørnbeth BA, Skotheim RI, Nesbakken A, Lothe RA (2021)
The expressed mutational landscape of microsatellite stable colorectal cancers
Genome Med, 13 (1), 142
DOI 10.1186/s13073-021-00955-2, PubMed 34470667
Svendsen HA, Meling TR, Nygaard V, Waagene S, Russnes H, Juell S, Rogne SG, Pahnke J, Helseth E, Fodstad Ø, Maelandsmo GM (2021)
Novel human melanoma brain metastasis models in athymic nude fox1^nu mice: Site-specific metastasis patterns reflecting their clinical origin
Cancer Med, 10 (23), 8604-8613
DOI 10.1002/cam4.4334, PubMed 34612023
Szybowska P, Kostas M, Wesche J, Haugsten EM, Wiedlocha A (2021)
Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling
Cells, 10 (6)
DOI 10.3390/cells10061342, PubMed 34071546
Sønstevold T, Engedal N, Torgersen ML (2021)
Perturbation of Cellular Redox Homeostasis Dictates Divergent Effects of Polybutyl Cyanoacrylate (PBCA) Nanoparticles on Autophagy
Cells, 10 (12)
DOI 10.3390/cells10123432, PubMed 34943939
Sørensen O, Andersen AM, Larsen SG, Giercksky KE, Flatmark K (2021)
Correction to: Intraperitoneal mitomycin C improves survival compared to cytoreductive surgery alone in an experimental model of highgrade pseudomyxoma peritonei
Clin Exp Metastasis, 38 (2), 253
DOI 10.1007/s10585-021-10084-0, PubMed 33649933
Tamhane T, Njenga RW, Burden RE, Bueth H, Maelandsmo GM, Haugen MH, Scott CJ, Brix K (2021)
Trafficking of Full-Length and N-Terminally Truncated Cathepsin B in Human Colorectal Carcinoma Cells
Appl. Sci.-Basel, 11 (24), 11936
DOI 10.3390/app112411936
Thorgersen EB, Asvall J, Frøysnes IS, Schjalm C, Larsen SG, Dueland S, Andersson Y, Fodstad Ø, Mollnes TE, Flatmark K (2021)
Increased Local Inflammatory Response to MOC31PE Immunotoxin After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Ann Surg Oncol, 28 (9), 5252-5262
DOI 10.1245/s10434-021-10022-0, PubMed 34019185
Thorgersen EB, Flatmark K (2021)
ASO Author Reflections: The Peritoneum is an Active Immunological Compartment
Ann Surg Oncol, 28 (9), 5263-5264
DOI 10.1245/s10434-021-10036-8, PubMed 33939046
Torices L, de Las Heras J, Arango-Lasprilla JC, Cortés JM, Nunes-Xavier CE, Pulido R (2021)
MMADHC premature termination codons in the pathogenesis of cobalamin D disorder: Potential of translational readthrough reconstitution
Mol Genet Metab Rep, 26, 100710
DOI 10.1016/j.ymgmr.2021.100710, PubMed 33552904
Taavitsainen S, Engedal N, Cao S, Handle F, Erickson A, Prekovic S, Wetterskog D, Tolonen T, Vuorinen EM, Kiviaho A, Nätkin R, Häkkinen T, Devlies W, Henttinen S, Kaarijärvi R, Lahnalampi M, Kaljunen H, Nowakowska K, Syvälä H, Bläuer M, Cremaschi P, Claessens F, Visakorpi T, Tammela TLJ, Murtola T et al. (2021)
Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse
Nat Commun, 12 (1), 5307
DOI 10.1038/s41467-021-25624-1, PubMed 34489465
Valsalakumari R, Yadava SK, Szwed M, Pandya AD, Mælandsmo GM, Torgersen ML, Iversen TG, Skotland T, Sandvig K, Giri J (2021)
Mechanism of cellular uptake and cytotoxicity of paclitaxel loaded lipid nanocapsules in breast cancer cells
Int J Pharm, 597, 120217
DOI 10.1016/j.ijpharm.2021.120217, PubMed 33486035
van der Zanden TM, Mooij MG, Vet NJ, Neubert A, Rascher W, Lagler FB, Male C, Grytli H, Halvorsen T, de Hoog M, de Wildt SN (2021)
Benefit-Risk Assessment of Off-Label Drug Use in Children: The Bravo Framework
Clin Pharmacol Ther, 110 (4), 952-965
DOI 10.1002/cpt.2336, PubMed 34145575
Vikan AK, Kostas M, Haugsten EM, Selbo PK, Wesche J (2021)
Efficacy and Selectivity of FGF2-Saporin Cytosolically Delivered by PCI in Cells Overexpressing FGFR1
Cells, 10 (6)
DOI 10.3390/cells10061476, PubMed 34204611
Wang N, Bai D, Kristiansen E, Deng R, Zhang S (2021)
AKIP1 promotes tumor progression by cancer-related pathways and predicts prognosis in tongue squamous cell carcinoma
Am J Transl Res, 13 (11), 12338-12351
PubMed 34956456
Wiedlocha A, Haugsten EM, Zakrzewska M (2021)
Roles of the FGF-FGFR Signaling System in Cancer Development and Inflammation
Cells, 10 (9)
DOI 10.3390/cells10092231, PubMed 34571880
Aamdal E, Inderberg EM, Ellingsen EB, Rasch W, Brunsvig PF, Aamdal S, Heintz KM, Vodák D, Nakken S, Hovig E, Nyakas M, Guren TK, Gaudernack G (2021)
Combining a Universal Telomerase Based Cancer Vaccine With Ipilimumab in Patients With Metastatic Melanoma - Five-Year Follow Up of a Phase I/IIa Trial
Front Immunol, 12, 663865
DOI 10.3389/fimmu.2021.663865, PubMed 34046035

Publications 2020

Aghayan DL, Kazaryan AM, Dagenborg VJ, Røsok BI, Fagerland MW, Waaler Bjørnelv GM, Kristiansen R, Flatmark K, Fretland ÅA, Edwin B, OSLO-COMET Survival Study Collaborators (2020)
Long-Term Oncologic Outcomes After Laparoscopic Versus Open Resection for Colorectal Liver Metastases : A Randomized Trial
Ann Intern Med, 174 (2), 175-182
DOI 10.7326/M20-4011, PubMed 33197213
Ahadova A, Seppälä TT, Engel C, Gallon R, Burn J, Holinski-Feder E, Steinke-Lange V, Möslein G, Nielsen M, Ten Broeke SW, Laghi L, Dominguez-Valentin M, Capella G, Macrae F, Scott R, Hüneburg R, Nattermann J, Hoffmeister M, Brenner H, Bläker H, von Knebel Doeberitz M, Sampson JR, Vasen H, Mecklin JP, Møller P et al. (2020)
The "unnatural" history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance
Int J Cancer, 148 (4), 800-811
DOI 10.1002/ijc.33224, PubMed 32683684
Álvarez K, Orellana P, De la Fuente M, Canales T, Pinto E, Heine C, Solar B, Hurtado C, Møller P, Kronberg U, Zarate AJ, Dominguez-Valentin M, López-Köstner F (2020)
Spectrum and Frequency of Tumors, Cancer Risk and Survival in Chilean Families with Lynch Syndrome: Experience of the Implementation of a Registry
J Clin Med, 9 (6)
DOI 10.3390/jcm9061861, PubMed 32549215
Arstad C, Taskén K, Refinetti P, Axcrona U, Giercksky KE, Ekstrøm PO (2020)
Somatic Mitochondrial DNA Point Mutations Used as Biomarkers to Demonstrate Genomic Heterogeneity in Primary Prostate Cancer
Prostate Cancer, 2020, 7673684
DOI 10.1155/2020/7673684, PubMed 32908706
Barkovskaya A, Seip K, Prasmickaite L, Mills IG, Moestue SA, Itkonen HM (2020)
Inhibition of O-GlcNAc transferase activates tumor-suppressor gene expression in tamoxifen-resistant breast cancer cells
Sci Rep, 10 (1), 16992
DOI 10.1038/s41598-020-74083-z, PubMed 33046784
Chen B, Dragomir MP, Fabris L, Bayraktar R, Knutsen E, Liu X, Tang C, Li Y, Shimura T, Ivkovic TC, De Los Santos MC, Anfossi S, Shimizu M, Shah MY, Ling H, Shen P, Multani AS, Pardini B, Burks JK, Katayama H, Reineke LC, Huo L, Syed M, Song S, Ferracin M et al. (2020)
The Long Noncoding RNA CCAT2 Induces Chromosomal Instability Through BOP1-AURKB Signaling
Gastroenterology, 159 (6), 2146-2162.e33
DOI 10.1053/j.gastro.2020.08.018, PubMed 32805281
Dagenborg VJ, Marshall SE, Yaqub S, Grzyb K, Boye K, Lund-Iversen M, Høye E, Berstad AE, Fretland ÅA, Edwin B, Ree AH, Flatmark K (2020)
Neoadjuvant chemotherapy is associated with a transient increase of intratumoral T-cell density in microsatellite stable colorectal liver metastases
Cancer Biol Ther, 21 (5), 432-440
DOI 10.1080/15384047.2020.1721252, PubMed 32098573
De Las Heras J, Diez I, Jimenez-Marin A, Cabrera A, Ramos-Usuga D, Diaz-Fernandez MV, Torices L, Nunes-Xavier CE, Pulido R, Arango-Lasprilla JC, Cortes JM (2020)
Brain Circuit Alterations and Cognitive Disability in Late-Onset Cobalamin D Disorder
J Clin Med, 9 (4)
DOI 10.3390/jcm9040990, PubMed 32252256
Dillard P, Köksal H, Maggadottir SM, Winge-Main A, Pollmann S, Menard M, Myhre MR, Mælandsmo GM, Flørenes VA, Gaudernack G, Kvalheim G, Wälchli S, Inderberg EM (2020)
Targeting Telomerase with an HLA Class II-Restricted TCR for Cancer Immunotherapy
Mol Ther, 29 (3), 1199-1213
DOI 10.1016/j.ymthe.2020.11.019, PubMed 33212301
Dominguez-Valentin M, Crosbie EJ, Engel C, Aretz S, Macrae F, Winship I, Capella G, Thomas H, Nakken S, Hovig E, Nielsen M, Sijmons RH, Bertario L, Bonanni B, Tibiletti MG, Cavestro GM, Mints M, Gluck N, Katz L, Heinimann K, Vaccaro CA, Green K, Lalloo F, Hill J, Schmiegel W et al. (2020)
Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report
Genet Med, 23 (4), 705-712
DOI 10.1038/s41436-020-01029-1, PubMed 33257847
Dominguez-Valentin M, Sampson JR, Møller P, Seppälä TT, PLSD Collaborators (2020)
Analysis in the Prospective Lynch Syndrome Database identifies sarcoma as part of the Lynch syndrome tumor spectrum
Int J Cancer, 148 (2), 512-513
DOI 10.1002/ijc.33214, PubMed 32783184
Dominguez-Valentin M, Sampson JR, Seppälä TT, Ten Broeke SW, Plazzer JP, Nakken S, Engel C, Aretz S, Jenkins MA, Sunde L, Bernstein I, Capella G, Balaguer F, Thomas H, Evans DG, Burn J, Greenblatt M, Hovig E, de Vos Tot Nederveen Cappel WH, Sijmons RH, Bertario L, Tibiletti MG, Cavestro GM, Lindblom A, Della Valle A et al. (2020)
Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database
Genet Med, 22 (9), 1569
DOI 10.1038/s41436-020-0892-4, PubMed 32690931
Dominguez-Valentin M, Seppälä TT, Engel C, Aretz S, Macrae F, Winship I, Capella G, Thomas H, Hovig E, Nielsen M, Sijmons RH, Bertario L, Bonanni B, Tibiletti MG, Cavestro GM, Mints M, Gluck N, Katz L, Heinimann K, Vaccaro CA, Green K, Lalloo F, Hill J, Schmiegel W, Vangala D et al. (2020)
Risk-Reducing Gynecological Surgery in Lynch Syndrome: Results of an International Survey from the Prospective Lynch Syndrome Database
J Clin Med, 9 (7)
DOI 10.3390/jcm9072290, PubMed 32708519
Flatmark K, Mohamed F (2020)
ASO Author Reflections: Estimating the Prevalence of Pseudomyxoma Peritonei in Europe Using a Novel Statistical Method
Ann Surg Oncol, 27 (Suppl 3), 771-772
DOI 10.1245/s10434-020-08691-4, PubMed 32495284
Flem-Karlsen K, Fodstad Ø, Nunes-Xavier CE (2020)
B7-H3 Immune Checkpoint Protein in Human Cancer
Curr Med Chem, 27 (24), 4062-4086
DOI 10.2174/0929867326666190517115515, PubMed 31099317
Flem-Karlsen K, Nyakas M, Farstad IN, McFadden E, Wernhoff P, Jacobsen KD, Flørenes VA, Mælandsmo GM (2020)
Soluble AXL as a marker of disease progression and survival in melanoma
PLoS One, 15 (1), e0227187
DOI 10.1371/journal.pone.0227187, PubMed 31917795
Fleten KG, Lund-Andersen C, Waagene S, Abrahamsen TW, Mørch Y, Boye K, Torgunrud A, Flatmark K (2020)
Experimental Treatment of Mucinous Peritoneal Metastases Using Patient-Derived Xenograft Models
Transl Oncol, 13 (8), 100793
DOI 10.1016/j.tranon.2020.100793, PubMed 32447231
Fromm B, Domanska D, Høye E, Ovchinnikov V, Kang W, Aparicio-Puerta E, Johansen M, Flatmark K, Mathelier A, Hovig E, Hackenberg M, Friedländer MR, Peterson KJ (2020)
MirGeneDB 2.0: the metazoan microRNA complement
Nucleic Acids Res, 48 (D1), D132-D141
DOI 10.1093/nar/gkz885, PubMed 31598695
Fromm B, Domanska D, Høye E, Ovchinnikov V, Kang W, Aparicio-Puerta E, Johansen M, Flatmark K, Mathelier A, Hovig E, Hackenberg M, Friedländer MR, Peterson KJ (2020)
MirGeneDB 2.0: the metazoan microRNA complement
Nucleic Acids Res, 48 (D1), D1172
DOI 10.1093/nar/gkz1016, PubMed 31642479
Georgiesh T, Boye K, Bjerkehagen B (2020)
A novel risk score to predict early and late recurrence in solitary fibrous tumour
Histopathology, 77 (1), 123-132
DOI 10.1111/his.14078, PubMed 31991494
Guldvik IJ, Zuber V, Braadland PR, Grytli HH, Ramberg H, Lilleby W, Thiede B, Zucknick M, Saatcioglu F, Gislefoss R, Kvåle R, George A, Grönberg H, Wiklund F, Neal DE, Gnanapragasam VJ, Taskén KA, Mills IG (2020)
Identification and Validation of Leucine-rich α-2-glycoprotein 1 as a Noninvasive Biomarker for Improved Precision in Prostate Cancer Risk Stratification
Eur Urol Open Sci, 21, 51-60
DOI 10.1016/j.euros.2020.08.007, PubMed 34337468
Halvorsen AR, Haugen MH, Öjlert ÅK, Lund-Iversen M, Jørgensen L, Solberg S, Mælandsmo GM, Brustugun OT, Helland Å (2020)
Protein Kinase C Isozymes Associated With Relapse Free Survival in Non-Small Cell Lung Cancer Patients
Front Oncol, 10, 590755
DOI 10.3389/fonc.2020.590755, PubMed 33324562
Hernández-Sandoval JA, Gutiérrez-Angulo M, Magaña-Torres MT, Alvizo-Rodríguez CR, Ramírez-Plascencia HHF, Flores-López BA, Valenzuela-Pérez JA, Peregrina-Sandoval J, Moreno-Ortiz JM, Domínguez-Valentín M, Ayala-Madrigal ML (2020)
Prevalence of the BRAF p.v600e variant in patients with colorectal cancer from Mexico and its estimated frequency in Latin American and Caribbean populations
J Investig Med, 68 (5), 985-991
DOI 10.1136/jim-2020-001301, PubMed 32184228
Humbert M, Morán M, de la Cruz-Ojeda P, Muntané J, Wiedmer T, Apostolova N, McKenna SL, Velasco G, Balduini W, Eckhart L, Janji B, Sampaio-Marques B, Ludovico P, Žerovnik E, Langer R, Perren A, Engedal N, Tschan MP (2020)
Assessing Autophagy in Archived Tissue or How to Capture Autophagic Flux from a Tissue Snapshot
Biology (Basel), 9 (3)
DOI 10.3390/biology9030059, PubMed 32245178
Itkonen HM, Poulose N, Steele RE, Martin SES, Levine ZG, Duveau DY, Carelli R, Singh R, Urbanucci A, Loda M, Thomas CJ, Mills IG, Walker S (2020)
Inhibition of O-GlcNAc Transferase Renders Prostate Cancer Cells Dependent on CDK9
Mol Cancer Res, 18 (10), 1512-1521
DOI 10.1158/1541-7786.MCR-20-0339, PubMed 32611550
Knutsen E, Lellahi SM, Aure MR, Nord S, Fismen S, Larsen KB, Gabriel MT, Hedberg A, Bjørklund SS, Oslo Breast Cancer Research Consortium (OSBREAC), Bofin AM, Mælandsmo GM, Sørlie T, Mortensen ES, Perander M (2020)
The expression of the long NEAT1_2 isoform is associated with human epidermal growth factor receptor 2-positive breast cancers
Sci Rep, 10 (1), 1277
DOI 10.1038/s41598-020-57759-4, PubMed 31992741
Kohvakka A, Sattari M, Shcherban A, Annala M, Urbanucci A, Kesseli J, Tammela TLJ, Kivinummi K, Latonen L, Nykter M, Visakorpi T (2020)
AR and ERG drive the expression of prostate cancer specific long noncoding RNAs
Oncogene, 39 (30), 5241-5251
DOI 10.1038/s41388-020-1365-6, PubMed 32555329
Kotsopoulos J, Karlan B, Gronwald J, Hall E, Moller P, Tung N, Zakalik D, Foulkes WD, Rosen B, Neuhausen SL, Sun P, Lubinksi J, Narod SA (2020)
Long-term outcomes following a diagnosis of ovarian cancer at the time of preventive oophorectomy among BRCA1 and BRCA2 mutation carriers
Int J Gynecol Cancer, 30 (6), 825-830
DOI 10.1136/ijgc-2019-001141, PubMed 32354794
Kramer I, Hooning MJ, Mavaddat N, Hauptmann M, Keeman R, Steyerberg EW, Giardiello D, Antoniou AC, Pharoah PDP, Canisius S, Abu-Ful Z, Andrulis IL, Anton-Culver H, Aronson KJ, Augustinsson A, Becher H, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Bogdanova NV, Bojesen SE, Bolla MK, Bonanni B, Brauch H et al. (2020)
Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk
Am J Hum Genet, 107 (5), 837-848
DOI 10.1016/j.ajhg.2020.09.001, PubMed 33022221
Lavelle TJ, Alver TN, Heintz KM, Wernhoff P, Nygaard V, Nakken S, Øy GF, Bøe SL, Urbanucci A, Hovig E (2020)
Dysregulation of MITF Leads to Transformation in MC1R-Defective Melanocytes
Cancers (Basel), 12 (7)
DOI 10.3390/cancers12071719, PubMed 32605315
Lien VT, Kristiansen MK, Pettersen S, Haugen MH, Krauss S, Olberg DE, Waaler J, Klaveness J (2020)
Correction: Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation
RSC Adv, 10 (9), 4927
DOI 10.1039/d0ra90007a, PubMed 35503286
Meltzer S, Bjørnetrø T, Lyckander LG, Flatmark K, Dueland S, Samiappan R, Johansen C, Kalanxhi E, Ree AH, Redalen KR (2020)
Corrigendum to "Circulating Exosomal miR-141-3p and miR-375 in Metastatic Progression of Rectal Cancer" [Transl Oncol 12 (8) (2019) 1038-1044]
Transl Oncol, 13 (1), 122-124
DOI 10.1016/j.tranon.2019.09.005, PubMed 31843135
Møller P (2020)
The Prospective Lynch Syndrome Database reports enable evidence-based personal precision health care
Hered Cancer Clin Pract, 18, 6
DOI 10.1186/s13053-020-0138-0, PubMed 32190163
Møller P, Dominguez-Valentin M, Rødland EA, Hovig E (2020)
Correction: Møller, P.; et al. Causes for Frequent Pathogenic BRCA1 Variants Include Low Penetrance in Fertile Ages, Recurrent De-Novo Mutations and Genetic Drift. Cancers 2019, 11, 132
Cancers (Basel), 12 (2)
DOI 10.3390/cancers12020410, PubMed 32050665
Møller P, Sampson J, Dominguez-Valentin M, Burn J, Sunde L, Möslein G, Mecklin JP, Seppälä T (2020)
Letter to the Editor-Recent advances in Lynch syndrome
Fam Cancer, 20 (2), 117-118
DOI 10.1007/s10689-020-00200-6, PubMed 32770425
Olafsdottir EJ, Borg A, Jensen MB, Gerdes AM, Johansson ALV, Barkardottir RB, Johannsson OT, Ejlertsen B, Sønderstrup IMH, Hovig E, Lænkholm AV, Hansen TVO, Olafsdottir GH, Rossing M, Jonasson JG, Sigurdsson S, Loman N, Nilsson MP, Narod SA, Tryggvadottir L (2020)
Breast cancer survival in Nordic BRCA2 mutation carriers-unconventional association with oestrogen receptor status
Br J Cancer, 123 (11), 1608-1615
DOI 10.1038/s41416-020-01056-4, PubMed 32939053
Pace M, Falappa M, Freschi A, Balzani E, Berteotti C, Lo Martire V, Kaveh F, Hovig E, Zoccoli G, Amici R, Cerri M, Urbanucci A, Tucci V (2020)
Loss of Snord116 impacts lateral hypothalamus, sleep, and food-related behaviors
JCI Insight, 5 (12)
DOI 10.1172/jci.insight.137495, PubMed 32365348
Pandya AD, Øverbye A, Sahariah P, Gaware VS, Høgset H, Masson M, Høgset A, Mælandsmo GM, Skotland T, Sandvig K, Iversen TG (2020)
Drug-Loaded Photosensitizer-Chitosan Nanoparticles for Combinatorial Chemo- and Photodynamic-Therapy of Cancer
Biomacromolecules, 21 (4), 1489-1498
DOI 10.1021/acs.biomac.0c00061, PubMed 32092254
Patrick-Brown TDJH, Carr NJ, Swanson DM, Larsen S, Mohamed F, Flatmark K (2020)
Estimating the Prevalence of Pseudomyxoma Peritonei in Europe Using a Novel Statistical Method
Ann Surg Oncol, 28 (1), 252-257
DOI 10.1245/s10434-020-08655-8, PubMed 32488520
Piñero TA, Soukarieh O, Rolain M, Alvarez K, López-Köstner F, Torrezan GT, Carraro DM, De Oliveira Nascimento IL, Bomfim TF, Machado-Lopes TMB, Freitas JC, Toralles MB, Sandes KA, Rossi BM, Junior SA, Meira J, Dominguez-Valentin M, Møller P, Vaccaro CA, Martins A, Pavicic WH (2020)
MLH1 intronic variants mapping to + 5 position of splice donor sites lead to deleterious effects on RNA splicing
Fam Cancer, 19 (4), 323-336
DOI 10.1007/s10689-020-00182-5, PubMed 32363481
Ree AH, Nygaard V, Boye K, Heinrich D, Dueland S, Bergheim IR, Johansen C, Beiske K, Negård A, Lund-Iversen M, Nygaard V, Hovig E, Nakken S, Nasser S, Julsrud L, Reisse CH, Ruud EA, Kristensen VN, Flørenes VA, Geitvik GA, Lingjærde OC, Børresen-Dale AL, Russnes HG, Mælandsmo GM, Flatmark K (2020)
Molecularly matched therapy in the context of sensitivity, resistance, and safety; patient outcomes in end-stage cancer - the MetAction study
Acta Oncol, 59 (7), 733-740
DOI 10.1080/0284186X.2020.1742377, PubMed 32208873
Refinetti P, Morgenthaler S, Thilly WG, Arstad C, Ekstrøm PO (2020)
Tracing of Human Tumor Cell Lineages by Mitochondrial Mutations
Front Oncol, 10, 523860
DOI 10.3389/fonc.2020.523860, PubMed 33344219
Saeednejad Zanjani L, Madjd Z, Axcrona U, Abolhasani M, Rasti A, Asgari M, Fodstad Ø, Andersson Y (2020)
Cytoplasmic expression of B7-H3 and membranous EpCAM expression are associated with higher grade and survival outcomes in patients with clear cell renal cell carcinoma
Ann Diagn Pathol, 46, 151483
DOI 10.1016/j.anndiagpath.2020.151483, PubMed 32143173
Salgado D, Armean IM, Baudis M, Beltran S, Capella-Gutierrez S, Carvalho-Silva D, Dominguez Del Angel V, Dopazo J, Furlong LI, Gao B, Garcia L, Gerloff D, Gut I, Gyenesei A, Habermann N, Hancock JM, Hanauer M, Hovig E, Johansson LF, Keane T, Korbel J, Lauer KB, Laurie S, Leskošek B, Lloyd D et al. (2020)
The ELIXIR Human Copy Number Variations Community: building bioinformatics infrastructure for research
F1000Res, 9
DOI 10.12688/f1000research.24887.1, PubMed 34367618
Seppälä TT, Dominguez-Valentin M, Sampson JR, Møller P (2020)
Prospective observational data informs understanding and future management of Lynch syndrome: insights from the Prospective Lynch Syndrome Database (PLSD)
Fam Cancer, 20 (1), 35-39
DOI 10.1007/s10689-020-00193-2, PubMed 32507935
Serguienko A, Braadland P, Meza-Zepeda LA, Bjerkehagen B, Myklebost O (2020)
Accurate 3-gene-signature for early diagnosis of liposarcoma progression
Clin Sarcoma Res, 10, 4
DOI 10.1186/s13569-020-0126-1, PubMed 32158531
Steinhaeuser SS, Morera E, Budkova Z, Schepsky A, Wang Q, Rolfsson O, Riedel A, Krueger A, Hilmarsdottir B, Maelandsmo GM, Valdimarsdottir B, Sigurdardottir AK, Agnarsson BA, Jonasson JG, Ingthorsson S, Traustadottir GA, Oskarsson T, Gudjonsson T (2020)
ECM1 secreted by HER2-overexpressing breast cancer cells promotes formation of a vascular niche accelerating cancer cell migration and invasion
Lab Invest, 100 (7), 928-944
DOI 10.1038/s41374-020-0415-6, PubMed 32203150
Sønstevold T, Engedal N, Mørch Ý, Iversen TG, Skotland T, Sandvig K, Torgersen ML (2020)
Structural Variants of poly(alkylcyanoacrylate) Nanoparticles Differentially Affect LC3 and Autophagic Cargo Degradation
J Biomed Nanotechnol, 16 (4), 432-445
DOI 10.1166/jbn.2020.2906, PubMed 32970976
Tadele DS, Robertson J, Crispin R, Herrera MC, Chlubnová M, Piechaczyk L, Ayuda-Durán P, Singh SK, Gedde-Dahl T, Fløisand Y, Skavland J, Wesche J, Gjertsen BT, Enserink JM (2020)
A cell competition-based small molecule screen identifies a novel compound that induces dual c-Myc depletion and p53 activation
J Biol Chem, 296, 100179
DOI 10.1074/jbc.RA120.015285, PubMed 33303632
Torgersen ML, Judge PJ, Bada Juarez JF, Pandya AD, Fusser M, Davies CW, Maciejewska MK, Yin DJ, Maelandsmo GM, Skotland T, Watts A, Sandvig K (2020)
Physicochemical Characterization, Toxicity and In Vivo Biodistribution Studies of a Discoidal, Lipid-Based Drug Delivery Vehicle: Lipodisq Nanoparticles Containing Doxorubicin
J Biomed Nanotechnol, 16 (4), 419-431
DOI 10.1166/jbn.2020.2911, PubMed 32970975
Wise JF, Nakken S, Steen CB, Vodák D, Trøen G, Johannessen B, Lingjærde OC, Hilden V, Blaker YN, Bai B, Aasheim LB, Pasanen A, Lorenz S, Sveen A, Lothe RA, Myklebost O, Leppä S, Meza-Zepeda LA, Beiske K, Lawrence MS, Hovig E, Myklebust JH, Smeland EB, Holte H (2020)
Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series
Blood Adv, 4 (9), 1859-1866
DOI 10.1182/bloodadvances.2019001325, PubMed 32374878
Waaler J, Mygland L, Tveita A, Strand MF, Solberg NT, Olsen PA, Aizenshtadt A, Fauskanger M, Lund K, Brinch SA, Lycke M, Dybing E, Nygaard V, Bøe SL, Heintz KM, Hovig E, Hammarström C, Corthay A, Krauss S (2020)
Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models
Commun Biol, 3 (1), 196
DOI 10.1038/s42003-020-0916-2, PubMed 32332858
Zhao S, Agafonov O, Azab A, Stokowy T, Hovig E (2020)
Accuracy and efficiency of germline variant calling pipelines for human genome data
Sci Rep, 10 (1), 20222
DOI 10.1038/s41598-020-77218-4, PubMed 33214604

Publications 2019

Abrahamsson H, Porojnicu AC, Lindstrøm JC, Dueland S, Flatmark K, Hole KH, Seierstad T, Moan J, Redalen KR, Meltzer S, Ree AH (2019)
High level of circulating vitamin D during neoadjuvant therapy may lower risk of metastatic progression in high-risk rectal cancer
BMC Cancer, 19 (1), 488
DOI 10.1186/s12885-019-5724-z, PubMed 31122213
Aghayan DL, Fretland ÅA, Kazaryan AM, Sahakyan MA, Dagenborg VJ, Bjørnbeth BA, Flatmark K, Kristiansen R, Edwin B (2019)
Laparoscopic versus open liver resection in the posterosuperior segments: a sub-group analysis from the OSLO-COMET randomized controlled trial
HPB (Oxford), 21 (11), 1485-1490
DOI 10.1016/j.hpb.2019.03.358, PubMed 30962136
Andersson Y, Inderberg EM, Kvalheim G, Herud TM, Engebraaten O, Flatmark K, Dueland S, Fodstad Ø (2019)
Immune stimulatory effect of anti-EpCAM immunotoxin - improved overall survival of metastatic colorectal cancer patients
Acta Oncol, 59 (4), 404-409
DOI 10.1080/0284186X.2019.1704864, PubMed 31876430
Bains SJ, Abrahamsson H, Flatmark K, Dueland S, Hole KH, Seierstad T, Redalen KR, Meltzer S, Ree AH (2019)
Immunogenic cell death by neoadjuvant oxaliplatin and radiation protects against metastatic failure in high-risk rectal cancer
Cancer Immunol Immunother, 69 (3), 355-364
DOI 10.1007/s00262-019-02458-x, PubMed 31893287
Barkovskaya A, Seip K, Hilmarsdottir B, Maelandsmo GM, Moestue SA, Itkonen HM (2019)
O-GlcNAc Transferase Inhibition Differentially Affects Breast Cancer Subtypes
Sci Rep, 9 (1), 5670
DOI 10.1038/s41598-019-42153-6, PubMed 30952976
Briem E, Ingthorsson S, Traustadottir GA, Hilmarsdottir B, Gudjonsson T (2019)
Application of the D492 Cell Lines to Explore Breast Morphogenesis, EMT and Cancer Progression in 3D Culture
J Mammary Gland Biol Neoplasia, 24 (2), 139-147
DOI 10.1007/s10911-018-09424-w, PubMed 30684066
Brudvik KW, Jones RP, Giuliante F, Shindoh J, Passot G, Chung MH, Song J, Li L, Dagenborg VJ, Fretland ÅA, Røsok B, De Rose AM, Ardito F, Edwin B, Panettieri E, Larocca LM, Yamashita S, Conrad C, Aloia TA, Poston GJ, Bjørnbeth BA, Vauthey JN (2019)
RAS Mutation Clinical Risk Score to Predict Survival After Resection of Colorectal Liver Metastases
Ann Surg, 269 (1), 120-126
DOI 10.1097/SLA.0000000000002319, PubMed 28549012
Braadland PR, Ramberg H, Grytli HH, Urbanucci A, Nielsen HK, Guldvik IJ, Engedal A, Ketola K, Wang W, Svindland A, Mills IG, Bjartell A, Taskén KA (2019)
The β₂-Adrenergic Receptor Is a Molecular Switch for Neuroendocrine Transdifferentiation of Prostate Cancer Cells
Mol Cancer Res, 17 (11), 2154-2168
DOI 10.1158/1541-7786.MCR-18-0605, PubMed 31395667
Braadland PR, Urbanucci A (2019)
Chromatin reprogramming as an adaptation mechanism in advanced prostate cancer
Endocr Relat Cancer, 26 (4), R211-R235
DOI 10.1530/ERC-18-0579, PubMed 30844748
Calvete J, Larrinaga G, Errarte P, Martín AM, Dotor A, Esquinas C, Nunes-Xavier CE, Pulido R, López JI, Angulo JC (2019)
The coexpression of fibroblast activation protein (FAP) and basal-type markers (CK 5/6 and CD44) predicts prognosis in high-grade invasive urothelial carcinoma of the bladder
Hum Pathol, 91, 61-68
DOI 10.1016/j.humpath.2019.07.002, PubMed 31279874
Camilio KA, Wang MY, Mauseth B, Waagene S, Kvalheim G, Rekdal Ø, Sveinbjørnsson B, Mælandsmo GM (2019)
Combining the oncolytic peptide LTX-315 with doxorubicin demonstrates therapeutic potential in a triple-negative breast cancer model
Breast Cancer Res, 21 (1), 9
DOI 10.1186/s13058-018-1092-x, PubMed 30670061
Crosbie EJ, Ryan NAJ, Arends MJ, Bosse T, Burn J, Cornes JM, Crawford R, Eccles D, Frayling IM, Ghaem-Maghami S, Hampel H, Kauff ND, Kitchener HC, Kitson SJ, Manchanda R, McMahon RFT, Monahan KJ, Menon U, Møller P, Möslein G, Rosenthal A, Sasieni P, Seif MW, Singh N, Skarrott P et al. (2019)
The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome
Genet Med, 21 (10), 2390-2400
DOI 10.1038/s41436-019-0489-y, PubMed 30918358
Debik J, Euceda LR, Lundgren S, Gythfeldt HVL, Garred Ø, Borgen E, Engebraaten O, Bathen TF, Giskeødegård GF (2019)
Assessing Treatment Response and Prognosis by Serum and Tissue Metabolomics in Breast Cancer Patients
J Proteome Res, 18 (10), 3649-3660
DOI 10.1021/acs.jproteome.9b00316, PubMed 31483662
Della Valle A, Rossi BM, Palmero EI, Antelo M, Vaccaro CA, López-Kostner F, Alvarez K, Cruz-Correa M, Bruno LI, Forones NM, Mindiola JAR, Buleje J, Spirandelli F, Bohorquez M, Cock-Rada AM, Sullcahuaman Y, Nascimento I, Abe-Sandes K, Lino-Silva LS, Petracchi F, Mampel A, Rodriguez Y, Rossi NT, Yañez CB, Rubio C et al. (2019)
A snapshot of current genetic testing practice in Lynch syndrome: The results of a representative survey of 33 Latin American existing centres/registries
Eur J Cancer, 119, 112-121
DOI 10.1016/j.ejca.2019.07.017, PubMed 31442815
Dominguez-Valentin M, Nakken S, Tubeuf H, Vodak D, Ekstrøm PO, Nissen AM, Morak M, Holinski-Feder E, Holth A, Capella G, Davidson B, Evans DG, Martins A, Møller P, Hovig E (2019)
Results of multigene panel testing in familial cancer cases without genetic cause demonstrated by single gene testing
Sci Rep, 9 (1), 18555
DOI 10.1038/s41598-019-54517-z, PubMed 31811167
Dominguez-Valentin M, Sampson JR, Seppälä TT, Ten Broeke SW, Plazzer JP, Nakken S, Engel C, Aretz S, Jenkins MA, Sunde L, Bernstein I, Capella G, Balaguer F, Thomas H, Evans DG, Burn J, Greenblatt M, Hovig E, de Vos Tot Nederveen Cappel WH, Sijmons RH, Bertario L, Tibiletti MG, Cavestro GM, Lindblom A, Della Valle A et al. (2019)
Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database
Genet Med, 22 (1), 15-25
DOI 10.1038/s41436-019-0596-9, PubMed 31337882
Dominguez-Valentin M, Seppälä TT, Sampson JR, Macrae F, Winship I, Evans DG, Scott RJ, Burn J, Möslein G, Bernstein I, Pylvänäinen K, Renkonen-Sinisalo L, Lepistö A, Lindblom A, Plazzer JP, Tjandra D, Thomas H, Green K, Lalloo F, Crosbie EJ, Hill J, Capella G, Pineda M, Navarro M, Vidal JB et al. (2019)
Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database report
Hered Cancer Clin Pract, 17, 28
DOI 10.1186/s13053-019-0127-3, PubMed 31636762
Dörk T, Peterlongo P, Mannermaa A, Bolla MK, Wang Q, Dennis J, Ahearn T, Andrulis IL, Anton-Culver H, Arndt V, Aronson KJ, Augustinsson A, Freeman LEB, Beckmann MW, Beeghly-Fadiel A, Behrens S, Bermisheva M, Blomqvist C, Bogdanova NV, Bojesen SE, Brauch H, Brenner H, Burwinkel B, Canzian F, Chan TL et al. (2019)
Two truncating variants in FANCC and breast cancer risk
Sci Rep, 9 (1), 12524
DOI 10.1038/s41598-019-48804-y, PubMed 31467304
Escala-Garcia M, Guo Q, Dörk T, Canisius S, Keeman R, Dennis J, Beesley J, Lecarpentier J, Bolla MK, Wang Q, Abraham J, Andrulis IL, Anton-Culver H, Arndt V, Auer PL, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Bernstein L, Blomqvist C, Boeckx B, Bojesen SE, Bonanni B, Børresen-Dale AL et al. (2019)
Genome-wide association study of germline variants and breast cancer-specific mortality
Br J Cancer, 120 (6), 647-657
DOI 10.1038/s41416-019-0393-x, PubMed 30787463
Flem-Karlsen K, McFadden E, Omar N, Haugen MH, Øy GF, Ryder T, Gullestad HP, Hermann R, Mælandsmo GM, Flørenes VA (2019)
Targeting AXL and the DNA Damage Response Pathway as a Novel Therapeutic Strategy in Melanoma
Mol Cancer Ther, 19 (3), 895-905
DOI 10.1158/1535-7163.MCT-19-0290, PubMed 31871265
Flem-Karlsen K, Tekle C, Øyjord T, Flørenes VA, Mælandsmo GM, Fodstad Ø, Nunes-Xavier CE (2019)
p38 MAPK activation through B7-H3-mediated DUSP10 repression promotes chemoresistance
Sci Rep, 9 (1), 5839
DOI 10.1038/s41598-019-42303-w, PubMed 30967582
Flørenes VA, Flem-Karlsen K, McFadden E, Bergheim IR, Nygaard V, Nygård V, Farstad IN, Øy GF, Emilsen E, Giller-Fleten K, Ree AH, Flatmark K, Gullestad HP, Hermann R, Ryder T, Wernhoff P, Mælandsmo GM (2019)
A Three-dimensional Ex Vivo Viability Assay Reveals a Strong Correlation Between Response to Targeted Inhibitors and Mutation Status in Melanoma Lymph Node Metastases
Transl Oncol, 12 (7), 951-958
DOI 10.1016/j.tranon.2019.04.001, PubMed 31096111
Forthun RB, Hovland R, Schuster C, Puntervoll H, Brodal HP, Namløs HM, Aasheim LB, Meza-Zepeda LA, Gjertsen BT, Knappskog S, Straume O (2019)
ctDNA detected by ddPCR reveals changes in tumour load in metastatic malignant melanoma treated with bevacizumab
Sci Rep, 9 (1), 17471
DOI 10.1038/s41598-019-53917-5, PubMed 31767937
Fretland ÅA, Dagenborg VJ, Waaler Bjørnelv GM, Aghayan DL, Kazaryan AM, Barkhatov L, Kristiansen R, Fagerland MW, Edwin B, Andersen MH (2019)
Quality of life from a randomized trial of laparoscopic or open liver resection for colorectal liver metastases
Br J Surg, 106 (10), 1372-1380
DOI 10.1002/bjs.11227, PubMed 31322735
Frøysnes IS, Andersson Y, Larsen SG, Davidson B, Øien JT, Julsrud L, Fodstad Ø, Dueland S, Flatmark K (2019)
ImmunoPeCa trial: Long-term outcome following intraperitoneal MOC31PE immunotoxin treatment in colorectal peritoneal metastasis
Eur J Surg Oncol, 47 (1), 134-138
DOI 10.1016/j.ejso.2019.04.014, PubMed 31036394
Goodridge JP, Jacobs B, Saetersmoen ML, Clement D, Hammer Q, Clancy T, Skarpen E, Brech A, Landskron J, Grimm C, Pfefferle A, Meza-Zepeda L, Lorenz S, Wiiger MT, Louch WE, Ask EH, Liu LL, Oei VYS, Kjällquist U, Linnarsson S, Patel S, Taskén K, Stenmark H, Malmberg KJ (2019)
Remodeling of secretory lysosomes during education tunes functional potential in NK cells
Nat Commun, 10 (1), 514
DOI 10.1038/s41467-019-08384-x, PubMed 30705279
Grinde MT, Hilmarsdottir B, Tunset HM, Henriksen IM, Kim J, Haugen MH, Rye MB, Mælandsmo GM, Moestue SA (2019)
Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer
Breast Cancer Res, 21 (1), 61
DOI 10.1186/s13058-019-1141-0, PubMed 31088535
Handle F, Prekovic S, Helsen C, Van den Broeck T, Smeets E, Moris L, Eerlings R, Kharraz SE, Urbanucci A, Mills IG, Joniau S, Attard G, Claessens F (2019)
Drivers of AR indifferent anti-androgen resistance in prostate cancer cells
Sci Rep, 9 (1), 13786
DOI 10.1038/s41598-019-50220-1, PubMed 31551480
Hanes R, Munthe E, Grad I, Han J, Karlsen I, McCormack E, Meza-Zepeda LA, Stratford EW, Myklebost O (2019)
Preclinical Evaluation of the Pan-FGFR Inhibitor LY2874455 in FRS2-Amplified Liposarcoma
Cells, 8 (2)
DOI 10.3390/cells8020189, PubMed 30795553
Hansen EP, Fromm B, Andersen SD, Marcilla A, Andersen KL, Borup A, Williams AR, Jex AR, Gasser RB, Young ND, Hall RS, Stensballe A, Ovchinnikov V, Yan Y, Fredholm M, Thamsborg SM, Nejsum P (2019)
Exploration of extracellular vesicles from Ascaris suum provides evidence of parasite-host cross talk
J Extracell Vesicles, 8 (1), 1578116
DOI 10.1080/20013078.2019.1578116, PubMed 30815237
Hausken J, Fretland ÅA, Edwin B, Andersen MH, Dagenborg VJ, Bjørnelv GMW, Kristiansen R, Røysland K, Kvarstein G, Tønnessen TI (2019)
Intravenous Patient-controlled Analgesia Versus Thoracic Epidural Analgesia After Open Liver Surgery: A Prospective, Randomized, Controlled, Noninferiority Trial
Ann Surg, 270 (2), 193-199
DOI 10.1097/SLA.0000000000003209, PubMed 30676382
Hausott B, Förste A, Zach F, Mangger S, Haugsten EM, Klimaschewski L (2019)
Endocytosis and Transport of Growth Factor Receptors in Peripheral Axon Regeneration: Novel Lessons from Neurons Expressing Lysine-Deficient FGF Receptor Type 1 in vitro
Anat Rec (Hoboken), 302 (8), 1268-1275
DOI 10.1002/ar.24120, PubMed 30950230
Itkonen HM, Urbanucci A, Martin SE, Khan A, Mathelier A, Thiede B, Walker S, Mills IG (2019)
High OGT activity is essential for MYC-driven proliferation of prostate cancer cells
Theranostics, 9 (8), 2183-2197
DOI 10.7150/thno.30834, PubMed 31149037
Johansson HJ, Socciarelli F, Vacanti NM, Haugen MH, Zhu Y, Siavelis I, Fernandez-Woodbridge A, Aure MR, Sennblad B, Vesterlund M, Branca RM, Orre LM, Huss M, Fredlund E, Beraki E, Garred Ø, Boekel J, Sauer T, Zhao W, Nord S, Höglander EK, Jans DC, Brismar H, Haukaas TH, Bathen TF et al. (2019)
Breast cancer quantitative proteome and proteogenomic landscape
Nat Commun, 10 (1), 1600
DOI 10.1038/s41467-019-09018-y, PubMed 30962452
Juraleviciute M, Pozniak J, Nsengimana J, Harland M, Randerson-Moor J, Wernhoff P, Bassarova A, Øy GF, Trøen G, Flørenes VA, Bishop DT, Herlyn M, Newton-Bishop J, Slipicevic A (2019)
MX 2 is a novel regulator of cell cycle in melanoma cells
Pigment Cell Melanoma Res, 33 (3), 446-457
DOI 10.1111/pcmr.12837, PubMed 31660681
Kanduri C, Bock C, Gundersen S, Hovig E, Sandve GK (2019)
Colocalization analyses of genomic elements: approaches, recommendations and challenges
Bioinformatics, 35 (9), 1615-1624
DOI 10.1093/bioinformatics/bty835, PubMed 30307532
Kotsopoulos J, Lubinski J, Lynch HT, Tung N, Armel S, Senter L, Singer CF, Fruscio R, Couch F, Weitzel JN, Karlan B, Foulkes WD, Moller P, Eisen A, Ainsworth P, Neuhausen SL, Olopade O, Sun P, Gronwald J, Narod SA, Hereditary Breast Cancer Clinical Study Group (2019)
Oophorectomy and risk of contralateral breast cancer among BRCA1 and BRCA2 mutation carriers
Breast Cancer Res Treat, 175 (2), 443-449
DOI 10.1007/s10549-019-05162-7, PubMed 30756284
Lai X, Geier OM, Fleischer T, Garred Ø, Borgen E, Funke SW, Kumar S, Rognes ME, Seierstad T, Børresen-Dale AL, Kristensen VN, Engebraaten O, Köhn-Luque A, Frigessi A (2019)
Toward Personalized Computer Simulation of Breast Cancer Treatment: A Multiscale Pharmacokinetic and Pharmacodynamic Model Informed by Multitype Patient Data
Cancer Res, 79 (16), 4293-4304
DOI 10.1158/0008-5472.CAN-18-1804, PubMed 31118201
Lien VT, Kristiansen MK, Pettersen S, Haugen MH, Olberg DE, Waaler J, Klaveness J (2019)
Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation
RSC Adv, 9 (63), 37092-37100
DOI 10.1039/c9ra08954c, PubMed 35539091
Lien VT, Pettersen S, Haugen MH, Olberg DE, Maelandsmo GM, Klaveness J (2019)
Design, synthesis and biological evaluation of 6-substituted quinolines derived from cabozantinib as c-Met inhibitors
Arch Pharm (Weinheim), 352 (9), e1900101
DOI 10.1002/ardp.201900101, PubMed 31414521
Lindholm EM, Ragle Aure M, Haugen MH, Kleivi Sahlberg K, Kristensen VN, Nebdal D, Børresen-Dale AL, Lingjaerde OC, Engebraaten O (2019)
miRNA expression changes during the course of neoadjuvant bevacizumab and chemotherapy treatment in breast cancer
Mol Oncol, 13 (10), 2278-2296
DOI 10.1002/1878-0261.12561, PubMed 31402562
Lund-Andersen C, Nakken S, Nygård S, Fromm B, Aasheim LB, Davidson B, Julsrud L, Abrahamsen TW, Kristensen AT, Dybdahl B, Larsen SG, Hovig E, Flatmark K (2019)
Integrative genomic analysis of peritoneal malignant mesothelioma: understanding a case with extraordinary chemotherapy response
Cold Spring Harb Mol Case Stud, 5 (2)
DOI 10.1101/mcs.a003566, PubMed 30862609
Mauseth B, Camilio KA, Shi J, Hammarström CL, Rekdal Ø, Sveinbjørnsson B, Line PD (2019)
The Novel Oncolytic Compound LTX-401 Induces Antitumor Immune Responses in Experimental Hepatocellular Carcinoma
Mol Ther Oncolytics, 14, 139-148
DOI 10.1016/j.omto.2019.05.002, PubMed 31211244
Meltzer S, Bakke KM, Rød KL, Negård A, Flatmark K, Solbakken AM, Kristensen AT, Fuglestad AJ, Kersten C, Dueland S, Seierstad T, Hole KH, Lyckander LG, Larsen FO, Schou JV, Patrick Brown D, Abrahamsson H, Redalen KR, Ree AH (2019)
Sex-related differences in primary metastatic site in rectal cancer; associated with hemodynamic factors?
Clin Transl Radiat Oncol, 21, 5-10
DOI 10.1016/j.ctro.2019.11.006, PubMed 31872084
Meltzer S, Bjørnetrø T, Lyckander LG, Flatmark K, Dueland S, Samiappan R, Johansen C, Kalanxhi E, Ree AH, Redalen KR (2019)
Circulating Exosomal miR-141-3p and miR-375 in Metastatic Progression of Rectal Cancer
Transl Oncol, 12 (8), 1038-1044
DOI 10.1016/j.tranon.2019.04.014, PubMed 31146167
Menden MP, Wang D, Mason MJ, Szalai B, Bulusu KC, Guan Y, Yu T, Kang J, Jeon M, Wolfinger R, Nguyen T, Zaslavskiy M, AstraZeneca-Sanger Drug Combination DREAM Consortium, Jang IS, Ghazoui Z, Ahsen ME, Vogel R, Neto EC, Norman T, Tang EKY, Garnett MJ, Veroli GYD, Fawell S, Stolovitzky G, Guinney J et al. (2019)
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
Nat Commun, 10 (1), 2674
DOI 10.1038/s41467-019-09799-2, PubMed 31209238
Metcalfe K, Eisen A, Senter L, Armel S, Bordeleau L, Meschino WS, Pal T, Lynch HT, Tung NM, Kwong A, Ainsworth P, Karlan B, Moller P, Eng C, Weitzel JN, Sun P, Lubinski J, Narod SA, Hereditary Breast Cancer Clinical Study Group (2019)
International trends in the uptake of cancer risk reduction strategies in women with a BRCA1 or BRCA2 mutation
Br J Cancer, 121 (1), 15-21
DOI 10.1038/s41416-019-0446-1, PubMed 30971774
Mingo J, Luna S, Gaafar A, Nunes-Xavier CE, Torices L, Mosteiro L, Ruiz R, Guerra I, Llarena R, Angulo JC, López JI, Pulido R (2019)
Precise definition of PTEN C-terminal epitopes and its implications in clinical oncology
NPJ Precis Oncol, 3, 11
DOI 10.1038/s41698-019-0083-4, PubMed 30993208
Møller P, Dominguez-Valentin M, Rødland EA, Hovig E (2019)
Causes for Frequent Pathogenic BRCA1 Variants Include Low Penetrance in Fertile Ages, Recurrent De-Novo Mutations and Genetic Drift
Cancers (Basel), 11 (2)
DOI 10.3390/cancers11020132, PubMed 30678073
Namløs HM, Boye K, Meza-Zepeda LA (2019)
Cell-free DNA in blood as a noninvasive insight into the sarcoma genome
Mol Aspects Med, 72, 100827
DOI 10.1016/j.mam.2019.10.004, PubMed 31703948
Njølstad PR, Andreassen OA, Brunak S, Børglum AD, Dillner J, Esko T, Franks PW, Freimer N, Groop L, Heimer H, Hougaard DM, Hovig E, Hveem K, Jalanko A, Kaprio J, Knudsen GP, Melbye M, Metspalu A, Mortensen PB, Palmgren J, Palotie A, Reed W, Stefánsson H, Stitziel NO, Sullivan PF et al. (2019)
Roadmap for a precision-medicine initiative in the Nordic region
Nat Genet, 51 (6), 924-930
DOI 10.1038/s41588-019-0391-1, PubMed 30988515
Nome ME, Euceda LR, Jabeen S, Debik J, Bathen TF, Giskeødegård GF, Taskén KA, Maelandsmo GM, Halvorsen B, Yndestad A, Borgen E, Garred Ø, Aukrust P, Ueland T, Engebraaten O, Kristensen VN, Tekpli X (2019)
Serum levels of inflammation-related markers and metabolites predict response to neoadjuvant chemotherapy with and without bevacizumab in breast cancers
Int J Cancer, 146 (1), 223-235
DOI 10.1002/ijc.32638, PubMed 31444972
Nunes-Xavier CE, Angulo JC, Pulido R, López JI (2019)
A Critical Insight into the Clinical Translation of PD-1/PD-L1 Blockade Therapy in Clear Cell Renal Cell Carcinoma
Curr Urol Rep, 20 (1), 1
DOI 10.1007/s11934-019-0866-8, PubMed 30645700
Nunes-Xavier CE, Aurtenetxe O, Zaldumbide L, López-Almaraz R, Erramuzpe A, Cortés JM, López JI, Pulido R (2019)
Protein tyrosine phosphatase PTPN1 modulates cell growth and associates with poor outcome in human neuroblastoma
Diagn Pathol, 14 (1), 134
DOI 10.1186/s13000-019-0919-9, PubMed 31837707
Nunes-Xavier CE, Zaldumbide L, Aurtenetxe O, López-Almaraz R, López JI, Pulido R (2019)
Dual-Specificity Phosphatases in Neuroblastoma Cell Growth and Differentiation
Int J Mol Sci, 20 (5)
DOI 10.3390/ijms20051170, PubMed 30866462
Nyakas M, Aamdal E, Jacobsen KD, Guren TK, Aamdal S, Hagene KT, Brunsvig P, Yndestad A, Halvorsen B, Tasken KA, Aukrust P, Maelandsmo GM, Ueland T (2019)
Prognostic biomarkers for immunotherapy with ipilimumab in metastatic melanoma
Clin Exp Immunol, 197 (1), 74-82
DOI 10.1111/cei.13283, PubMed 30821848
Nygård S, Lingjærde OC, Caldas C, Hovig E, Børresen-Dale AL, Helland Å, Haakensen VD (2019)
PathTracer: High-sensitivity detection of differential pathway activity in tumours
Sci Rep, 9 (1), 16332
DOI 10.1038/s41598-019-52529-3, PubMed 31704995
Pandya AD, Jäger E, Bagheri Fam S, Höcherl A, Jäger A, Sincari V, Nyström B, Štěpánek P, Skotland T, Sandvig K, Hrubý M, Mælandsmo GM (2019)
Paclitaxel-loaded biodegradable ROS-sensitive nanoparticles for cancer therapy
Int J Nanomedicine, 14, 6269-6285
DOI 10.2147/IJN.S208938, PubMed 31496685
Pashov A, Shivarov V, Hadzhieva M, Kostov V, Ferdinandov D, Heintz KM, Pashova S, Todorova M, Vassilev T, Kieber-Emmons T, Meza-Zepeda LA, Hovig E (2019)
Diagnostic Profiling of the Human Public IgM Repertoire With Scalable Mimotope Libraries
Front Immunol, 10, 2796
DOI 10.3389/fimmu.2019.02796, PubMed 31849974
Pfefferle A, Jacobs B, Netskar H, Ask EH, Lorenz S, Clancy T, Goodridge JP, Sohlberg E, Malmberg KJ (2019)
Intra-lineage Plasticity and Functional Reprogramming Maintain Natural Killer Cell Repertoire Diversity
Cell Rep, 29 (8), 2284-2294.e4
DOI 10.1016/j.celrep.2019.10.058, PubMed 31747601
Pitman KE, Alluri SR, Kristian A, Aarnes EK, Lyng H, Riss PJ, Malinen E (2019)
Influx rate of ¹⁸F-fluoroaminosuberic acid reflects cystine/glutamate antiporter expression in tumour xenografts
Eur J Nucl Med Mol Imaging, 46 (10), 2190-2198
DOI 10.1007/s00259-019-04375-8, PubMed 31264167
Pitman KE, Bakke KM, Kristian A, Malinen E (2019)
Ultra-early changes in vascular parameters from dynamic contrast enhanced MRI of breast cancer xenografts following systemic therapy with doxorubicin and liver X receptor agonist
Cancer Imaging, 19 (1), 88
DOI 10.1186/s40644-019-0280-y, PubMed 31856923
Pulido R, Mingo J, Gaafar A, Nunes-Xavier CE, Luna S, Torices L, Angulo JC, López JI (2019)
Precise Immunodetection of PTEN Protein in Human Neoplasia
Cold Spring Harb Perspect Med, 9 (12)
DOI 10.1101/cshperspect.a036293, PubMed 31501265
Ree AH, Nygaard V, Russnes HG, Heinrich D, Nygaard V, Johansen C, Bergheim IR, Hovig E, Beiske K, Negård A, Børresen-Dale AL, Flatmark K, Mælandsmo GM (2019)
Responsiveness to PD-1 Blockade in End-Stage Colon Cancer with Gene Locus 9p24.1 Copy-Number Gain
Cancer Immunol Res, 7 (5), 701-706
DOI 10.1158/2326-6066.CIR-18-0777, PubMed 30804006
Saeednejad Zanjani L, Madjd Z, Rasti A, Asgari M, Abolhasani M, Tam KJ, Roudi R, Mælandsmo GM, Fodstad Ø, Andersson Y (2019)
Spheroid-Derived Cells From Renal Adenocarcinoma Have Low Telomerase Activity and High Stem-Like and Invasive Characteristics
Front Oncol, 9, 1302
DOI 10.3389/fonc.2019.01302, PubMed 31921617
Sampson JR, Dominguez-Valentin M, Seppälä TT, Møller P (2019)
Response to Tolva et al
Genet Med, 22 (4), 813-814
DOI 10.1038/s41436-019-0717-5, PubMed 31801985
Seppälä TT, Ahadova A, Dominguez-Valentin M, Macrae F, Evans DG, Therkildsen C, Sampson J, Scott R, Burn J, Möslein G, Bernstein I, Holinski-Feder E, Pylvänäinen K, Renkonen-Sinisalo L, Lepistö A, Lautrup CK, Lindblom A, Plazzer JP, Winship I, Tjandra D, Katz LH, Aretz S, Hüneburg R, Holzapfel S, Heinimann K et al. (2019)
Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report
Hered Cancer Clin Pract, 17, 8
DOI 10.1186/s13053-019-0106-8, PubMed 30858900
Shu X, Wu L, Khankari NK, Shu XO, Wang TJ, Michailidou K, Bolla MK, Wang Q, Dennis J, Milne RL, Schmidt MK, Pharoah PDP, Andrulis IL, Hunter DJ, Simard J, Easton DF, Zheng W, Breast Cancer Association Consortium (2019)
Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis
Int J Epidemiol, 48 (3), 795-806
DOI 10.1093/ije/dyy201, PubMed 30277539
Sneeggen M, Pedersen NM, Campsteijn C, Haugsten EM, Stenmark H, Schink KO (2019)
WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling
Nat Commun, 10 (1), 2850
DOI 10.1038/s41467-019-10794-w, PubMed 31253801
Szybowska P, Kostas M, Wesche J, Wiedlocha A, Haugsten EM (2019)
Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1/2 Pathway
Cells, 8 (6)
DOI 10.3390/cells8060518, PubMed 31146385
Sørensen O, Andersen AM, Larsen SG, Giercksky KE, Flatmark K (2019)
Intraperitoneal mitomycin C improves survival compared to cytoreductive surgery alone in an experimental model of high-grade pseudomyxoma peritonei
Clin Exp Metastasis, 36 (6), 511-518
DOI 10.1007/s10585-019-09991-0, PubMed 31541325
Tekpli X, Lien T, Røssevold AH, Nebdal D, Borgen E, Ohnstad HO, Kyte JA, Vallon-Christersson J, Fongaard M, Due EU, Svartdal LG, Sveli MAT, Garred Ø, OSBREAC, Frigessi A, Sahlberg KK, Sørlie T, Russnes HG, Naume B, Kristensen VN (2019)
An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment
Nat Commun, 10 (1), 5499
DOI 10.1038/s41467-019-13329-5, PubMed 31796750
Ten Broeke SW, Rodríguez-Girondo M, Suerink M, Aretz S, Bernstein I, Capellá G, Engel C, Gomez-Garcia EB, van Hest LP, von Knebel Doeberitz M, Lagerstedt-Robinson K, Letteboer TGW, Moller P, van Os TA, Pineda M, Rahner N, Olderode-Berends MJW, von Salomé J, Schackert HK, Spruijt L, Steinke-Lange V, Wagner A, Tops CMJ, Nielsen M (2019)
The Apparent Genetic Anticipation in PMS2-Associated Lynch Syndrome Families Is Explained by Birth-cohort Effect
Cancer Epidemiol Biomarkers Prev, 28 (6), 1010-1014
DOI 10.1158/1055-9965.EPI-18-0576, PubMed 30824524
Tolios A, De Las Rivas J, Hovig E, Trouillas P, Scorilas A, Mohr T (2019)
Computational approaches in cancer multidrug resistance research: Identification of potential biomarkers, drug targets and drug-target interactions
Drug Resist Updat, 48, 100662
DOI 10.1016/j.drup.2019.100662, PubMed 31927437
Webb M, Manley K, Olivan M, Guldvik I, Palczynska M, Hurst R, Connell SP, Mills IG, Brewer DS, Mills R, Cooper CS, Clark J (2019)
Methodology for the at-home collection of urine samples for prostate cancer detection
Biotechniques, 68 (2), 65-71
DOI 10.2144/btn-2019-0092, PubMed 31779479
Zakrzewska M, Opalinski L, Haugsten EM, Otlewski J, Wiedlocha A (2019)
Crosstalk between p38 and Erk 1/2 in Downregulation of FGF1-Induced Signaling
Int J Mol Sci, 20 (8)
DOI 10.3390/ijms20081826, PubMed 31013829

Publications 2018

Aurtenetxe O, Zaldumbide L, Erramuzpe A, López R, López JI, Cortés JM, Pulido R, Nunes-Xavier CE (2018)
DUSP5 expression associates with poor prognosis in human neuroblastoma
Exp Mol Pathol, 105 (3), 272-278
DOI 10.1016/j.yexmp.2018.08.008, PubMed 30171833
Berg J, Halvorsen AR, Bengtson MB, Taskén KA, Mælandsmo GM, Yndestad A, Halvorsen B, Brustugun OT, Aukrust P, Ueland T, Helland Å (2018)
Levels and prognostic impact of circulating markers of inflammation, endothelial activation and extracellular matrix remodelling in patients with lung cancer and chronic obstructive pulmonary disease
BMC Cancer, 18 (1), 739
DOI 10.1186/s12885-018-4659-0, PubMed 30005623
Birkeland E, Zhang S, Poduval D, Geisler J, Nakken S, Vodak D, Meza-Zepeda LA, Hovig E, Myklebost O, Knappskog S, Lønning PE (2018)
Patterns of genomic evolution in advanced melanoma
Nat Commun, 9 (1), 2665
DOI 10.1038/s41467-018-05063-1, PubMed 29991680
Bousquet PA, Meltzer S, Sønstevold L, Esbensen Y, Dueland S, Flatmark K, Sitter B, Bathen TF, Seierstad T, Redalen KR, Eide L, Ree AH (2018)
Markers of Mitochondrial Metabolism in Tumor Hypoxia, Systemic Inflammation, and Adverse Outcome of Rectal Cancer
Transl Oncol, 12 (1), 76-83
DOI 10.1016/j.tranon.2018.09.010, PubMed 30273860
Boye K, Berner JM, Hompland I, Bruland ØS, Stoldt S, Sundby Hall K, Bjerkehagen B, Hølmebakk T (2018)
Genotype and risk of tumour rupture in gastrointestinal stromal tumour
Br J Surg, 105 (2), e169-e175
DOI 10.1002/bjs.10743, PubMed 29341147
Briem E, Budkova Z, Sigurdardottir AK, Hilmarsdottir B, Kricker J, Timp W, Magnusson MK, Traustadottir GA, Gudjonsson T (2018)
MiR-203a is differentially expressed during branching morphogenesis and EMT in breast progenitor cells and is a repressor of peroxidasin
Mech Dev, 155, 34-47
DOI 10.1016/j.mod.2018.11.002, PubMed 30508578
Braadland PR, Giskeødegård G, Sandsmark E, Bertilsson H, Euceda LR, Hansen AF, Guldvik IJ, Selnæs KM, Grytli HH, Katz B, Svindland A, Bathen TF, Eri LM, Nygård S, Berge V, Taskén KA, Tessem MB (2018)
Ex vivo metabolic fingerprinting identifies biomarkers predictive of prostate cancer recurrence following radical prostatectomy
Br J Cancer, 118 (6), e11
DOI 10.1038/bjc.2017.470, PubMed 29462127
Bråte J, Neumann RS, Fromm B, Haraldsen AAB, Tarver JE, Suga H, Donoghue PCJ, Peterson KJ, Ruiz-Trillo I, Grini PE, Shalchian-Tabrizi K (2018)
Unicellular Origin of the Animal MicroRNA Machinery
Curr Biol, 28 (20), 3288-3295.e5
DOI 10.1016/j.cub.2018.08.018, PubMed 30318349
Dominguez-Valentin M, Evans DGR, Nakken S, Tubeuf H, Vodak D, Ekstrøm PO, Nissen AM, Morak M, Holinski-Feder E, Martins A, Møller P, Hovig E (2018)
Genetic variants of prospectively demonstrated phenocopies in BRCA1/2 kindreds
Hered Cancer Clin Pract, 16, 4
DOI 10.1186/s13053-018-0086-0, PubMed 29371908
Dominguez-Valentin M, Nakken S, Tubeuf H, Vodak D, Ekstrøm PO, Nissen AM, Morak M, Holinski-Feder E, Martins A, Møller P, Hovig E (2018)
Potentially pathogenic germline CHEK2 c.319+2T>A among multiple early-onset cancer families
Fam Cancer, 17 (1), 141-153
DOI 10.1007/s10689-017-0011-0, PubMed 28608266
Dominguez-Valentin M, Nakken S, Tubeuf H, Vodak D, Ekstrøm PO, Nissen AM, Morak M, Holinski-Feder E, Martins A, Møller P, Hovig E (2018)
Identification of genetic variants for clinical management of familial colorectal tumors
BMC Med Genet, 19 (1), 26
DOI 10.1186/s12881-018-0533-9, PubMed 29458332
Ebenesersdóttir SS, Sandoval-Velasco M, Gunnarsdóttir ED, Jagadeesan A, Guðmundsdóttir VB, Thordardóttir EL, Einarsdóttir MS, Moore KHS, Sigurðsson Á, Magnúsdóttir DN, Jónsson H, Snorradóttir S, Hovig E, Møller P, Kockum I, Olsson T, Alfredsson L, Hansen TF, Werge T, Cavalleri GL, Gilbert E, Lalueza-Fox C, Walser JW, Kristjánsdóttir S, Gopalakrishnan S et al. (2018)
Ancient genomes from Iceland reveal the making of a human population
Science, 360 (6392), 1028-1032
DOI 10.1126/science.aar2625, PubMed 29853688
Eng MS, Kaur J, Prasmickaite L, Engesæter BØ, Weyergang A, Skarpen E, Berg K, Rosenblum MG, Mælandsmo GM, Høgset A, Ferrone S, Selbo PK (2018)
Enhanced targeting of triple-negative breast carcinoma and malignant melanoma by photochemical internalization of CSPG4-targeting immunotoxins
Photochem Photobiol Sci, 17 (5), 539-551
DOI 10.1039/C7PP00358G, PubMed 29565434
Fafilek B, Balek L, Bosakova MK, Varecha M, Nita A, Gregor T, Gudernova I, Krenova J, Ghosh S, Piskacek M, Jonatova L, Cernohorsky NH, Zieba JT, Kostas M, Haugsten EM, Wesche J, Erneux C, Trantirek L, Krakow D, Krejci P (2018)
The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases
Sci Signal, 11 (548)
DOI 10.1126/scisignal.aap8608, PubMed 30228226
Flem-Karlsen K, Fodstad Ø, Tan M, Nunes-Xavier CE (2018)
B7-H3 in Cancer - Beyond Immune Regulation
Trends Cancer, 4 (6), 401-404
DOI 10.1016/j.trecan.2018.03.010, PubMed 29860983
Fretland ÅA, Dagenborg VJ, Bjørnelv GMW, Kazaryan AM, Kristiansen R, Fagerland MW, Hausken J, Tønnessen TI, Abildgaard A, Barkhatov L, Yaqub S, Røsok BI, Bjørnbeth BA, Andersen MH, Flatmark K, Aas E, Edwin B (2018)
Laparoscopic Versus Open Resection for Colorectal Liver Metastases: The OSLO-COMET Randomized Controlled Trial
Ann Surg, 267 (2), 199-207
DOI 10.1097/SLA.0000000000002353, PubMed 28657937
Fromm B, Kang W, Rovira C, Cayota A, Witwer K, Friedländer MR, Tosar JP (2018)
Plant microRNAs in human sera are likely contaminants
J Nutr Biochem, 65, 139-140
DOI 10.1016/j.jnutbio.2018.07.019, PubMed 30266285
Fromm B, Tosar JP, Lu Y, Halushka MK, Witwer KW (2018)
Human and Cow Have Identical miR-21-5p and miR-30a-5p Sequences, Which Are Likely Unsuited to Study Dietary Uptake from Cow Milk
J Nutr, 148 (9), 1506-1507
DOI 10.1093/jn/nxy144, PubMed 30184228
Fusser M, Øverbye A, Pandya AD, Mørch Ý, Borgos SE, Kildal W, Snipstad S, Sulheim E, Fleten KG, Askautrud HA, Engebraaten O, Flatmark K, Iversen TG, Sandvig K, Skotland T, Mælandsmo GM (2018)
Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft
J Control Release, 293, 183-192
DOI 10.1016/j.jconrel.2018.11.029, PubMed 30529259
González ML, Causada-Calo N, Santino JP, Dominguez-Valentin M, Ferro FA, Sammartino I, Kalfayan PG, Verzura MA, Piñero TA, Cajal AR, Pavicic W, Vaccaro C (2018)
Universal determination of microsatellite instability using BAT26 as a single marker in an Argentine colorectal cancer cohort
Fam Cancer, 17 (3), 395-402
DOI 10.1007/s10689-017-0052-4, PubMed 29128931
Gouravan S, Meza-Zepeda LA, Myklebost O, Stratford EW, Munthe E (2018)
Preclinical Evaluation of Vemurafenib as Therapy for BRAF^V600E Mutated Sarcomas
Int J Mol Sci, 19 (4)
DOI 10.3390/ijms19040969, PubMed 29570692
Halushka MK, Fromm B, Peterson KJ, McCall MN (2018)
Big Strides in Cellular MicroRNA Expression
Trends Genet, 34 (3), 165-167
DOI 10.1016/j.tig.2017.12.015, PubMed 29361313
Ibrahim I, Dominguez-Valentin M, Segal B, Zeitouni A, da Silva SD (2018)
Mitochondrial mutations associated with hearing and balance disorders
Mutat Res, 810, 39-44
DOI 10.1016/j.mrfmmm.2018.03.003, PubMed 29615272
Jacobs B, Pfefferle A, Clement D, Berg-Larsen A, Saetersmoen ML, Lorenz S, Wiiger MT, Goodridge JP, Malmberg KJ (2018)
Induction of the BIM Short Splice Variant Sensitizes Proliferating NK Cells to IL-15 Withdrawal
J Immunol, 202 (3), 736-746
DOI 10.4049/jimmunol.1801146, PubMed 30578306
Kalanxhi E, Meltzer S, Schou JV, Larsen FO, Dueland S, Flatmark K, Jensen BV, Hole KH, Seierstad T, Redalen KR, Nielsen DL, Ree AH (2018)
Systemic immune response induced by oxaliplatin-based neoadjuvant therapy favours survival without metastatic progression in high-risk rectal cancer
Br J Cancer, 118 (10), 1322-1328
DOI 10.1038/s41416-018-0085-y, PubMed 29695770
Kim SJ, Huzarski T, Gronwald J, Singer CF, Møller P, Lynch HT, Armel S, Karlan BY, Foulkes WD, Neuhausen SL, Senter L, Eisen A, Eng C, Panchal S, Pal T, Olopade O, Zakalik D, Lubinski J, Narod SA, Kotsopoulos J, (2018)
Prospective evaluation of body size and breast cancer risk among BRCA1 and BRCA2 mutation carriers
Int J Epidemiol, 47 (3), 987-997
DOI 10.1093/ije/dyy039, PubMed 29547931
Kostas M, Haugsten EM, Zhen Y, Sørensen V, Szybowska P, Fiorito E, Lorenz S, Jones N, de Souza GA, Wiedlocha A, Wesche J (2018)
Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors
Mol Cell Proteomics, 17 (5), 850-870
DOI 10.1074/mcp.RA117.000538, PubMed 29371290
Kotsopoulos J, Gronwald J, Karlan B, Rosen B, Huzarski T, Moller P, Lynch HT, Singer CF, Senter L, Neuhausen SL, Tung N, Eisen A, Foulkes WD, Ainsworth P, Sun P, Lubinski J, Narod SA, Hereditary Ovarian Cancer Clinical Study Group (2018)
Age-specific ovarian cancer risks among women with a BRCA1 or BRCA2 mutation
Gynecol Oncol, 150 (1), 85-91
DOI 10.1016/j.ygyno.2018.05.011, PubMed 29793803
Kotsopoulos J, Gronwald J, Karlan BY, Huzarski T, Tung N, Moller P, Armel S, Lynch HT, Senter L, Eisen A, Singer CF, Foulkes WD, Jacobson MR, Sun P, Lubinski J, Narod SA, Hereditary Breast Cancer Clinical Study Group (2018)
Hormone Replacement Therapy After Oophorectomy and Breast Cancer Risk Among BRCA1 Mutation Carriers
JAMA Oncol, 4 (8), 1059-1065
DOI 10.1001/jamaoncol.2018.0211, PubMed 29710224
Kresse SH, Namløs HM, Lorenz S, Berner JM, Myklebost O, Bjerkehagen B, Meza-Zepeda LA (2018)
Evaluation of commercial DNA and RNA extraction methods for high-throughput sequencing of FFPE samples
PLoS One, 13 (5), e0197456
DOI 10.1371/journal.pone.0197456, PubMed 29771965
Köger N, Paulsen L, López-Kostner F, Della Valle A, Vaccaro CA, Palmero EI, Alvarez K, Sarroca C, Neffa F, Kalfayan PG, Gonzalez ML, Rossi BM, Reis RM, Brieger A, Zeuzem S, Hinrichsen I, Dominguez-Valentin M, Plotz G (2018)
Evaluation of MLH1 variants of unclear significance
Genes Chromosomes Cancer, 57 (7), 350-358
DOI 10.1002/gcc.22536, PubMed 29520894
Løvf M, Zhao S, Axcrona U, Johannessen B, Bakken AC, Carm KT, Hoff AM, Myklebost O, Meza-Zepeda LA, Lie AK, Axcrona K, Lothe RA, Skotheim RI (2018)
Multifocal Primary Prostate Cancer Exhibits High Degree of Genomic Heterogeneity
Eur Urol, 75 (3), 498-505
DOI 10.1016/j.eururo.2018.08.009, PubMed 30181068
Mariathasan AB, Boye K, Giercksky KE, Brennhovd B, Gullestad HP, Emblemsvåg HL, Grøholt KK, Dueland S, Flatmark K, Larsen SG (2018)
Beyond total mesorectal excision in locally advanced rectal cancer with organ or pelvic side-wall involvement
Eur J Surg Oncol, 44 (8), 1226-1232
DOI 10.1016/j.ejso.2018.03.029, PubMed 29691115
Mavaddat N, Michailidou K, Dennis J, Lush M, Fachal L, Lee A, Tyrer JP, Chen TH, Wang Q, Bolla MK, Yang X, Adank MA, Ahearn T, Aittomäki K, Allen J, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Aronson KJ, Auer PL, Auvinen P, Barrdahl M, Beane Freeman LE, Beckmann MW et al. (2018)
Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes
Am J Hum Genet, 104 (1), 21-34
DOI 10.1016/j.ajhg.2018.11.002, PubMed 30554720
Mikalsen SG, Mikalsen LTG, Sandvik JA, Aarnes EK, Fenne S, Flatmark K, Lyng H, Edin NFJ, Pettersen EO (2018)
Low dose-rate irradiation with [³H]-labelled valine to selectively target hypoxic cells in a human colorectal cancer xenograft model
Acta Oncol, 57 (9), 1216-1224
DOI 10.1080/0284186X.2018.1457223, PubMed 29630428
Møller P, Hovig E (2018)
Retraction Note to: The BRCA2 variant c.68-7 T > A is associated with breast cancer
Hered Cancer Clin Pract, 16, 10
DOI 10.1186/s13053-018-0093-1, PubMed 29745381
Namløs HM, Boye K, Mishkin SJ, Barøy T, Lorenz S, Bjerkehagen B, Stratford EW, Munthe E, Kudlow BA, Myklebost O, Meza-Zepeda LA (2018)
Noninvasive Detection of ctDNA Reveals Intratumor Heterogeneity and Is Associated with Tumor Burden in Gastrointestinal Stromal Tumor
Mol Cancer Ther, 17 (11), 2473-2480
DOI 10.1158/1535-7163.MCT-18-0174, PubMed 30097488
Nunes-Xavier CE, Mingo J, López JI, Pulido R (2018)
The role of protein tyrosine phosphatases in prostate cancer biology
Biochim Biophys Acta Mol Cell Res, 1866 (1), 102-113
DOI 10.1016/j.bbamcr.2018.06.016, PubMed 30401533
Prasmickaite L, Tenstad EM, Pettersen S, Jabeen S, Egeland EV, Nord S, Pandya A, Haugen MH, Kristensen VN, Børresen-Dale AL, Oslo Breast Cancer Research Consortium (OSBREAC), Engebråten O, Maelandsmo GM (2018)
Basal-like breast cancer engages tumor-supportive macrophages via secreted factors induced by extracellular S100A4
Mol Oncol, 12 (9), 1540-1558
DOI 10.1002/1878-0261.12319, PubMed 29741811
Prencipe M, Fabre A, Murphy TB, Vargyas E, O'Neill A, Bjartell A, Tasken KA, Grytli HH, Svindland A, Berge V, Eri LM, Gallagher W, Watson RW (2018)
Role of serum response factor expression in prostate cancer biochemical recurrence
Prostate, 78 (10), 724-730
DOI 10.1002/pros.23516, PubMed 29608018
Saeednejad Zanjani L, Madjd Z, Abolhasani M, Rasti A, Shariftabrizi A, Mehrazma M, Fodstad Ø, Asgari M (2018)
Human telomerase reverse transcriptase protein expression predicts tumour aggressiveness and survival in patients with clear cell renal cell carcinoma
Pathology, 51 (1), 21-31
DOI 10.1016/j.pathol.2018.08.019, PubMed 30466948
Seip K, Jørgensen K, Haselager MV, Albrecht M, Haugen MH, Egeland EV, Lucarelli P, Engebraaten O, Sauter T, Mælandsmo GM, Prasmickaite L (2018)
Stroma-induced phenotypic plasticity offers phenotype-specific targeting to improve melanoma treatment
Cancer Lett, 439, 1-13
DOI 10.1016/j.canlet.2018.09.023, PubMed 30240588
Spasojevic M, Mariathasan AB, Goscinski M, Thorgersen EB, Solbakken AM, Gullestad HP, Ryder T, Flatmark K, Larsen SG (2018)
Vertical Rectus Abdominis Musculocutaneous Flap Repair Improves Perineal Wound Healing after Abdominoperineal Resection for Irradiated Locally Advanced Rectal Cancer
Ann Surg Oncol, 25 (5), 1357-1365
DOI 10.1245/s10434-018-6363-3, PubMed 29497909
Tarver JE, Taylor RS, Puttick MN, Lloyd GT, Pett W, Fromm B, Schirrmeister BE, Pisani D, Peterson KJ, Donoghue PCJ (2018)
Well-Annotated microRNAomes Do Not Evidence Pervasive miRNA Loss
Genome Biol Evol, 10 (6), 1457-1470
DOI 10.1093/gbe/evy096, PubMed 29788279
Ten Broeke SW, van der Klift HM, Tops CMJ, Aretz S, Bernstein I, Buchanan DD, de la Chapelle A, Capella G, Clendenning M, Engel C, Gallinger S, Gomez Garcia E, Figueiredo JC, Haile R, Hampel HL, Hopper JL, Hoogerbrugge N, von Knebel Doeberitz M, Le Marchand L, Letteboer TGW, Jenkins MA, Lindblom A, Lindor NM, Mensenkamp AR, Møller P et al. (2018)
Cancer Risks for PMS2-Associated Lynch Syndrome
J Clin Oncol, 36 (29), 2961-2968
DOI 10.1200/JCO.2018.78.4777, PubMed 30161022
Vaccaro CA, López-Kostner F, Adriana DV, Palmero EI, Rossi BM, Antelo M, Solano A, Carraro DM, Forones NM, Bohorquez M, Lino-Silva LS, Buleje J, Spirandelli F, Abe-Sandes K, Nascimento I, Sullcahuaman Y, Sarroca C, Gonzalez ML, Herrando AI, Alvarez K, Neffa F, Galvão HC, Esperon P, Golubicki M, Cisterna D et al. (2018)
From colorectal cancer pattern to the characterization of individuals at risk: Picture for genetic research in Latin America
Int J Cancer, 145 (2), 318-326
DOI 10.1002/ijc.31920, PubMed 30303536
Vodák D, Lorenz S, Nakken S, Aasheim LB, Holte H, Bai B, Myklebost O, Meza-Zepeda LA, Hovig E (2018)
Sample-Index Misassignment Impacts Tumour Exome Sequencing
Sci Rep, 8 (1), 5307
DOI 10.1038/s41598-018-23563-4, PubMed 29593270
Westrøm S, Bønsdorff TB, Bruland ØS, Larsen RH (2018)
Therapeutic Effect of α-Emitting ²²⁴Ra-Labeled Calcium Carbonate Microparticles in Mice with Intraperitoneal Ovarian Cancer
Transl Oncol, 11 (2), 259-267
DOI 10.1016/j.tranon.2017.12.011, PubMed 29413758
Westrøm S, Malenge M, Jorstad IS, Napoli E, Bruland ØS, Bønsdorff TB, Larsen RH (2018)
Ra-224 labeling of calcium carbonate microparticles for internal α-therapy: Preparation, stability, and biodistribution in mice
J Labelled Comp Radiopharm, 61 (6), 472-486
DOI 10.1002/jlcr.3610, PubMed 29380410
Zhen Y, Haugsten EM, Singh SK, Wesche J (2018)
Proximity Labeling by a Recombinant APEX2-FGF1 Fusion Protein Reveals Interaction of FGF1 with the Proteoglycans CD44 and CSPG4
Biochemistry, 57 (26), 3807-3816
DOI 10.1021/acs.biochem.8b00120, PubMed 29812912

Publications 2017

Andersson Y, Haavardtun SI, Davidson B, Dørum A, Fleten KG, Fodstad Ø, Flatmark K (2017)
MOC31PE immunotoxin - targeting peritoneal metastasis from epithelial ovarian cancer
Oncotarget, 8 (37), 61800-61809
DOI 10.18632/oncotarget.18694, PubMed 28977905
Arstad C, Refinetti P, Kristensen AT, Giercksky KE, Ekstrøm PO (2017)
Is detection of intraperitoneal exfoliated tumor cells after surgical resection of rectal cancer a prognostic factor of survival?
BMC Cancer, 17 (1), 406
DOI 10.1186/s12885-017-3365-7, PubMed 28592327
Aure MR, Vitelli V, Jernström S, Kumar S, Krohn M, Due EU, Haukaas TH, Leivonen SK, Vollan HK, Lüders T, Rødland E, Vaske CJ, Zhao W, Møller EK, Nord S, Giskeødegård GF, Bathen TF, Caldas C, Tramm T, Alsner J, Overgaard J, Geisler J, Bukholm IR, Naume B, Schlichting E et al. (2017)
Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome
Breast Cancer Res, 19 (1), 44
DOI 10.1186/s13058-017-0812-y, PubMed 28356166
Bakke KM, Hole KH, Dueland S, Grøholt KK, Flatmark K, Ree AH, Seierstad T, Redalen KR (2017)
Diffusion-weighted magnetic resonance imaging of rectal cancer: tumour volume and perfusion fraction predict chemoradiotherapy response and survival
Acta Oncol, 56 (6), 813-818
DOI 10.1080/0284186X.2017.1287951, PubMed 28464745
Behjati S, Tarpey PS, Haase K, Ye H, Young MD, Alexandrov LB, Farndon SJ, Collord G, Wedge DC, Martincorena I, Cooke SL, Davies H, Mifsud W, Lidgren M, Martin S, Latimer C, Maddison M, Butler AP, Teague JW, Pillay N, Shlien A, McDermott U, Futreal PA, Baumhoer D, Zaikova O et al. (2017)
Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma
Nat Commun, 8, 15936
DOI 10.1038/ncomms15936, PubMed 28643781
Berg KCG, Eide PW, Eilertsen IA, Johannessen B, Bruun J, Danielsen SA, Bjørnslett M, Meza-Zepeda LA, Eknæs M, Lind GE, Myklebost O, Skotheim RI, Sveen A, Lothe RA (2017)
Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies
Mol Cancer, 16 (1), 116
DOI 10.1186/s12943-017-0691-y, PubMed 28683746
Braadland PR, Giskeødegård G, Sandsmark E, Bertilsson H, Euceda LR, Hansen AF, Guldvik IJ, Selnæs KM, Grytli HH, Katz B, Svindland A, Bathen TF, Eri LM, Nygård S, Berge V, Taskén KA, Tessem MB (2017)
Ex vivo metabolic fingerprinting identifies biomarkers predictive of prostate cancer recurrence following radical prostatectomy
Br J Cancer, 117 (11), 1656-1664
DOI 10.1038/bjc.2017.346, PubMed 28972967
Byrne AT, Alférez DG, Amant F, Annibali D, Arribas J, Biankin AV, Bruna A, Budinská E, Caldas C, Chang DK, Clarke RB, Clevers H, Coukos G, Dangles-Marie V, Eckhardt SG, Gonzalez-Suarez E, Hermans E, Hidalgo M, Jarzabek MA, de Jong S, Jonkers J, Kemper K, Lanfrancone L, Mælandsmo GM, Marangoni E et al. (2017)
Interrogating open issues in cancer precision medicine with patient-derived xenografts
Nat Rev Cancer, 17 (4), 254-268
DOI 10.1038/nrc.2016.140, PubMed 28104906
Byrne AT, Alférez DG, Amant F, Annibali D, Arribas J, Biankin AV, Bruna A, Budinská E, Caldas C, Chang DK, Clarke RB, Clevers H, Coukos G, Dangles-Marie V, Eckhardt SG, Gonzalez-Suarez E, Hermans E, Hidalgo M, Jarzabek MA, de Jong S, Jonkers J, Kemper K, Lanfrancone L, Mælandsmo GM, Marangoni E et al. (2017)
Interrogating open issues in cancer medicine with patient-derived xenografts
Nat Rev Cancer, 17 (10), 632 (in press)
DOI 10.1038/nrc.2017.85, PubMed 28912576
Clancy T, Dannenfelser R, Troyanskaya O, Malmberg KJ, Hovig E, Kristensen V (2017)
Bioinformatics Approaches to Profile the Tumor Microenvironment for Immunotherapeutic Discovery
Curr Pharm Des, 23 (32), 4716-4725
DOI 10.2174/1381612823666170710154936, PubMed 28699527
Domanska D, Vodák D, Lund-Andersen C, Salvatore S, Hovig E, Sandve GK (2017)
The rainfall plot: its motivation, characteristics and pitfalls
BMC Bioinformatics, 18 (1), 264
DOI 10.1186/s12859-017-1679-8, PubMed 28521741
Egeland EV, Boye K, Park D, Synnestvedt M, Sauer T, Oslo Breast Cancer Consortium (OSBREAC), Naume B, Borgen E, Mælandsmo GM (2017)
Prognostic significance of S100A4-expression and subcellular localization in early-stage breast cancer
Breast Cancer Res Treat, 162 (1), 127-137
DOI 10.1007/s10549-016-4096-1, PubMed 28058579
Egger B, Bachmann L, Fromm B (2017)
Atp8 is in the ground pattern of flatworm mitochondrial genomes
BMC Genomics, 18 (1), 414
DOI 10.1186/s12864-017-3807-2, PubMed 28549457
Eide N, Faye RS, Høifødt HK, Sandvik L, Qvale GA, Faber R, Jebsen P, Kvalheim G, Fodstad Ø (2017)
The Results of Stricter Inclusion Criteria in an Immunomagnetic Detection Study of Micrometastatic Cells in Bone Marrow of Uveal Melanoma Patients - Relevance for Dormancy
Pathol Oncol Res, 25 (1), 255-262
DOI 10.1007/s12253-017-0355-7, PubMed 29098521
Engkvist ME, Stratford EW, Lorenz S, Meza-Zepeda LA, Myklebost O, Munthe E (2017)
Analysis of the miR-34 family functions in breast cancer reveals annotation error of miR-34b
Sci Rep, 7 (1), 9655
DOI 10.1038/s41598-017-10189-1, PubMed 28848235
Euceda LR, Haukaas TH, Giskeodegard GF, Vettukattil R, Engel J, Silwal-Pandit L, Lundgren S, Borgen E, Garred O, Postma G, Buydens LMC, Borresen-Dale AL, Engebraaten O, Bathen TF (2017)
Evaluation of metabolomic changes during neoadjuvant chemotherapy combined with bevacizumab in breast cancer using MR spectroscopy
Metabolomics, 13 (4), 37
DOI 10.1007/s11306-017-1168-0
Flem-Karlsen K, Tekle C, Andersson Y, Flatmark K, Fodstad Ø, Nunes-Xavier CE (2017)
Immunoregulatory protein B7-H3 promotes growth and decreases sensitivity to therapy in metastatic melanoma cells
Pigment Cell Melanoma Res, 30 (5), 467-476
DOI 10.1111/pcmr.12599, PubMed 28513992
Fromm B, Ovchinnikov V, Høye E, Bernal D, Hackenberg M, Marcilla A (2017)
On the presence and immunoregulatory functions of extracellular microRNAs in the trematode Fasciola hepatica
Parasite Immunol, 39 (2)
DOI 10.1111/pim.12399, PubMed 27809346
Frøysnes IS, Andersson Y, Larsen SG, Davidson B, Øien JT, Olsen KH, Giercksky KE, Julsrud L, Fodstad Ø, Dueland S, Flatmark K (2017)
Novel Treatment with Intraperitoneal MOC31PE Immunotoxin in Colorectal Peritoneal Metastasis: Results From the ImmunoPeCa Phase 1 Trial
Ann Surg Oncol, 24 (7), 1916-1922
DOI 10.1245/s10434-017-5814-6, PubMed 28224367
Graudenzi A, Cava C, Bertoli G, Fromm B, Flatmark K, Mauri G, Castiglioni I (2017)
Pathway-based classification of breast cancer subtypes
Front Biosci (Landmark Ed), 22 (10), 1697-1712
DOI 10.2741/4566, PubMed 28410140
Halldorsson S, Rohatgi N, Magnusdottir M, Choudhary KS, Gudjonsson T, Knutsen E, Barkovskaya A, Hilmarsdottir B, Perander M, Mælandsmo GM, Gudmundsson S, Rolfsson Ó (2017)
Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transition
Cancer Lett, 396, 117-129
DOI 10.1016/j.canlet.2017.03.019, PubMed 28323032
Helland Å, Brustugun OT, Nakken S, Halvorsen AR, Dønnem T, Bremnes R, Busund LT, Sun J, Lorenz S, Solberg SK, Jørgensen LH, Vodak D, Myklebost O, Hovig E, Meza-Zepeda LA (2017)
High number of kinome-mutations in non-small cell lung cancer is associated with reduced immune response and poor relapse-free survival
Int J Cancer, 141 (1), 184-190
DOI 10.1002/ijc.30726, PubMed 28387924
Hilmarsdottir B, Briem E, Halldorsson S, Kricker J, Ingthorsson S, Gustafsdottir S, Mælandsmo GM, Magnusson MK, Gudjonsson T (2017)
Inhibition of PTP1B disrupts cell-cell adhesion and induces anoikis in breast epithelial cells
Cell Death Dis, 8 (5), e2769
DOI 10.1038/cddis.2017.177, PubMed 28492548
Hompland I, Bruland ØS, Hølmebakk T, Poulsen JP, Stoldt S, Hall KS, Boye K (2017)
Prediction of long-term survival in patients with metastatic gastrointestinal stromal tumor: analysis of a large, single-institution cohort
Acta Oncol, 56 (10), 1317-1323
DOI 10.1080/0284186X.2017.1330555, PubMed 28557540
Jernström S, Hongisto V, Leivonen SK, Due EU, Tadele DS, Edgren H, Kallioniemi O, Perälä M, Mælandsmo GM, Sahlberg KK (2017)
Drug-screening and genomic analyses of HER2-positive breast cancer cell lines reveal predictors for treatment response
Breast Cancer (Dove Med Press), 9, 185-198
DOI 10.2147/BCTT.S115600, PubMed 28356768
Jiao X, Aravidis C, Marikkannu R, Rantala J, Picelli S, Adamovic T, Liu T, Maguire P, Kremeyer B, Luo L, von Holst S, Kontham V, Thutkawkorapin J, Margolin S, Du Q, Lundin J, Michailidou K, Bolla MK, Wang Q, Dennis J, Lush M, Ambrosone CB, Andrulis IL, Anton-Culver H, Antonenkova NN et al. (2017)
PHIP - a novel candidate breast cancer susceptibility locus on 6q14.1
Oncotarget, 8 (61), 102769-102782
DOI 10.18632/oncotarget.21800, PubMed 29262523
Kanduri C, Domanska D, Hovig E, Sandve GK (2017)
Genome build information is an essential part of genomic track files
Genome Biol, 18 (1), 175
DOI 10.1186/s13059-017-1312-1, PubMed 28911336
Kivinummi K, Urbanucci A, Leinonen K, Tammela TLJ, Annala M, Isaacs WB, Bova GS, Nykter M, Visakorpi T (2017)
The expression of AURKA is androgen regulated in castration-resistant prostate cancer
Sci Rep, 7 (1), 17978
DOI 10.1038/s41598-017-18210-3, PubMed 29269934
Kristian A, Holtedahl JE, Torheim T, Futsaether C, Hernes E, Engebraaten O, Mælandsmo GM, Malinen E (2017)
Dynamic 2-Deoxy-2-[¹⁸F]Fluoro-D-Glucose Positron Emission Tomography for Chemotherapy Response Monitoring of Breast Cancer Xenografts
Mol Imaging Biol, 19 (2), 271-279
DOI 10.1007/s11307-016-0998-x, PubMed 27541026
Landfors M, Johansen J, Aronsen JM, Vågbø CB, Doré LC, He C, Sjaastad I, Sætrom P, Fedorcsák P, Dahl JA, Aanes H, Fußer M, Klungland A (2017)
Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation
Cell Discov, 3, 17013
DOI 10.1038/celldisc.2017.13, PubMed 28529766
Lim S, Phillips JB, Madeira da Silva L, Zhou M, Fodstad O, Owen LB, Tan M (2017)
Interplay between Immune Checkpoint Proteins and Cellular Metabolism
Cancer Res, 77 (6), 1245-1249
DOI 10.1158/0008-5472.CAN-16-1647, PubMed 28246276
Lunde NN, Haugen MH, Bodin Larsen KB, Damgaard I, Pettersen SJ, Kasem R, Rut W, Drag M, Poreba M, Johansen HT, Solberg R (2017)
Glycosylation is important for legumain localization and processing to active forms but not for cystatin E/M inhibitory functions
Biochimie, 139, 27-37
DOI 10.1016/j.biochi.2017.05.009, PubMed 28528272
Meisal R, Rounge TB, Christiansen IK, Eieland AK, Worren MM, Molden TF, Kommedal Ø, Hovig E, Leegaard TM, Ambur OH (2017)
HPV Genotyping of Modified General Primer-Amplicons Is More Analytically Sensitive and Specific by Sequencing than by Hybridization
PLoS One, 12 (1), e0169074
DOI 10.1371/journal.pone.0169074, PubMed 28045981
Møller P, Hovig E (2017)
The BRCA2 variant c.68-7 T>A is associated with breast cancer
Hered Cancer Clin Pract, 15, 20 (Retracted)
DOI 10.1186/s13053-017-0080-y, PubMed 29158857
Møller P, Seppälä TT, Bernstein I, Holinski-Feder E, Sala P, Gareth Evans D, Lindblom A, Macrae F, Blanco I, Sijmons RH, Jeffries J, Vasen HFA, Burn J, Nakken S, Hovig E, Rødland EA, Tharmaratnam K, de Vos Tot Nederveen Cappel WH, Hill J, Wijnen JT, Jenkins MA, Green K, Lalloo F, Sunde L, Mints M et al. (2017)
Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database
Gut, 67 (7), 1306-1316
DOI 10.1136/gutjnl-2017-314057, PubMed 28754778
Namløs HM, Zaikova O, Bjerkehagen B, Vodák D, Hovig E, Myklebost O, Boye K, Meza-Zepeda LA (2017)
Use of liquid biopsies to monitor disease progression in a sarcoma patient: a case report
BMC Cancer, 17 (1), 29
DOI 10.1186/s12885-016-2992-8, PubMed 28061772
Nestvold J, Wang MY, Camilio KA, Zinöcker S, Tjelle TE, Lindberg A, Haug BE, Kvalheim G, Sveinbjørnsson B, Rekdal Ø (2017)
Oncolytic peptide LTX-315 induces an immune-mediated abscopal effect in a rat sarcoma model
Oncoimmunology, 6 (8), e1338236
DOI 10.1080/2162402X.2017.1338236, PubMed 28920000
Nygaard V, Rødland EA, Hovig E (2017)
Reply to Towfic and others' letter to the editor
Biostatistics, 18 (3), 586-587
DOI 10.1093/biostatistics/kxx001, PubMed 28334081
Ovchinnikov VY, Mordvinov VA, Fromm B (2017)
Extreme conservation of miRNA complements in opisthorchiids
Parasitol Int, 66 (6), 773-776
DOI 10.1016/j.parint.2017.09.006, PubMed 28916307
Ree AH, Russnes HG, Heinrich D, Dueland S, Boye K, Nygaard V, Silwal-Pandit L, Østrup O, Hovig E, Nygaard V, Rødland EA, Nakken S, Øien JT, Johansen C, Bergheim IR, Skarpeteig V, Sathermugathevan M, Sauer T, Lund-Iversen M, Beiske K, Nasser S, Julsrud L, Reisse CH, Ruud EA, Flørenes VA et al. (2017)
Implementing precision cancer medicine in the public health services of Norway: the diagnostic infrastructure and a cost estimate
ESMO Open, 2 (2), e000158
DOI 10.1136/esmoopen-2017-000158, PubMed 28761742
Refinetti P, Arstad C, Thilly WG, Morgenthaler S, Ekstrøm PO (2017)
Mapping mitochondrial heteroplasmy in a Leydig tumor by laser capture micro-dissection and cycling temperature capillary electrophoresis
BMC Clin Pathol, 17, 6
DOI 10.1186/s12907-017-0042-3, PubMed 28405177
Rossi BM, Palmero EI, López-Kostner F, Sarroca C, Vaccaro CA, Spirandelli F, Ashton-Prolla P, Rodriguez Y, de Campos Reis Galvão H, Reis RM, Escremim de Paula A, Capochin Romagnolo LG, Alvarez K, Della Valle A, Neffa F, Kalfayan PG, Spirandelli E, Chialina S, Gutiérrez Angulo M, Castro-Mujica MDC, Sanchez de Monte J, Quispe R, da Silva SD, Rossi NT, Barletta-Carrillo C et al. (2017)
A survey of the clinicopathological and molecular characteristics of patients with suspected Lynch syndrome in Latin America
BMC Cancer, 17 (1), 623
DOI 10.1186/s12885-017-3599-4, PubMed 28874130
Rustad EH, Coward E, Skytøen ER, Misund K, Holien T, Standal T, Børset M, Beisvag V, Myklebost O, Meza-Zepeda LA, Dai HY, Sundan A, Waage A (2017)
Monitoring multiple myeloma by quantification of recurrent mutations in serum
Haematologica, 102 (7), 1266-1272
DOI 10.3324/haematol.2016.160564, PubMed 28385781
Saeednejad Zanjani L, Madjd Z, Abolhasani M, Andersson Y, Rasti A, Shariftabrizi A, Asgari M (2017)
Cytoplasmic expression of CD133 stemness marker is associated with tumor aggressiveness in clear cell renal cell carcinoma
Exp Mol Pathol, 103 (2), 218-228
DOI 10.1016/j.yexmp.2017.10.001, PubMed 29050853
Saldova R, Haakensen VD, Rødland E, Walsh I, Stöckmann H, Engebraaten O, Børresen-Dale AL, Rudd PM (2017)
Serum N-glycome alterations in breast cancer during multimodal treatment and follow-up
Mol Oncol, 11 (10), 1361-1379
DOI 10.1002/1878-0261.12105, PubMed 28657165
Seppälä T, Pylvänäinen K, Evans DG, Järvinen H, Renkonen-Sinisalo L, Bernstein I, Holinski-Feder E, Sala P, Lindblom A, Macrae F, Blanco I, Sijmons R, Jeffries J, Vasen H, Burn J, Nakken S, Hovig E, Rødland EA, Tharmaratnam K, de Vos Tot Nederveen Cappel WH, Hill J, Wijnen J, Jenkins M, Genuardi M, Green K et al. (2017)
Colorectal cancer incidence in path_MLH1 carriers subjected to different follow-up protocols: a Prospective Lynch Syndrome Database report
Hered Cancer Clin Pract, 15, 18
DOI 10.1186/s13053-017-0078-5, PubMed 29046738
Serguienko A, Hanes R, Grad I, Wang MY, Myklebost O, Munthe E (2017)
PP2A Regulatory Subunit B55γ is a Gatekeeper of Osteoblast Maturation and Lineage Maintenance
Stem Cells Dev, 26 (19), 1375-1383
DOI 10.1089/scd.2017.0129, PubMed 28805158
Simovski B, Vodák D, Gundersen S, Domanska D, Azab A, Holden L, Holden M, Grytten I, Rand K, Drabløs F, Johansen M, Mora A, Lund-Andersen C, Fromm B, Eskeland R, Gabrielsen OS, Ferkingstad E, Nakken S, Bengtsen M, Nederbragt AJ, Thorarensen HS, Akse JA, Glad I, Hovig E, Sandve GK (2017)
GSuite HyperBrowser: integrative analysis of dataset collections across the genome and epigenome
Gigascience, 6 (7), 1-12
DOI 10.1093/gigascience/gix032, PubMed 28459977
Sveen A, Johannessen B, Tengs T, Danielsen SA, Eilertsen IA, Lind GE, Berg KCG, Leithe E, Meza-Zepeda LA, Domingo E, Myklebost O, Kerr D, Tomlinson I, Nesbakken A, Skotheim RI, Lothe RA (2017)
Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1
Genome Med, 9 (1), 46
DOI 10.1186/s13073-017-0434-0, PubMed 28539123
Sveinbjørnsson B, Camilio KA, Haug BE, Rekdal Ø (2017)
LTX-315: a first-in-class oncolytic peptide that reprograms the tumor microenvironment
Future Med Chem, 9 (12), 1339-1344
DOI 10.4155/fmc-2017-0088, PubMed 28490192
Umu SU, Langseth H, Bucher-Johannessen C, Fromm B, Keller A, Meese E, Lauritzen M, Leithaug M, Lyle R, Rounge TB (2017)
A comprehensive profile of circulating RNAs in human serum
RNA Biol, 15 (2), 242-250
DOI 10.1080/15476286.2017.1403003, PubMed 29219730
Urbanucci A, Barfeld SJ, Kytölä V, Itkonen HM, Coleman IM, Vodák D, Sjöblom L, Sheng X, Tolonen T, Minner S, Burdelski C, Kivinummi KK, Kohvakka A, Kregel S, Takhar M, Alshalalfa M, Davicioni E, Erho N, Lloyd P, Karnes RJ, Ross AE, Schaeffer EM, Vander Griend DJ, Knapp S, Corey E et al. (2017)
Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer
Cell Rep, 19 (10), 2045-2059
DOI 10.1016/j.celrep.2017.05.049, PubMed 28591577
Voisset E, Moravcsik E, Stratford EW, Jaye A, Palgrave CJ, Hills RK, Salomoni P, Kogan SC, Solomon E, Grimwade D (2017)
Pml nuclear body disruption cooperates in APL pathogenesis and impairs DNA damage repair pathways in mice
Blood, 131 (6), 636-648
DOI 10.1182/blood-2017-07-794784, PubMed 29191918
Wang MY, Nestvold J, Rekdal Ø, Kvalheim G, Fodstad Ø (2017)
A novel rat fibrosarcoma cell line from transformed bone marrow-derived mesenchymal stem cells with maintained in vitro and in vivo stemness properties
Exp Cell Res, 352 (2), 218-224
DOI 10.1016/j.yexcr.2017.02.005, PubMed 28189639
Westrøm S, Generalov R, Bønsdorff TB, Larsen RH (2017)
Preparation of ²¹²Pb-labeled monoclonal antibody using a novel ²²⁴Ra-based generator solution
Nucl Med Biol, 51, 1-9
DOI 10.1016/j.nucmedbio.2017.04.005, PubMed 28486098
Zanjani LS, Madjd Z, Abolhasani M, Rasti A, Fodstad O, Andersson Y, Asgari M (2017)
Increased expression of CD44 is associated with more aggressive behavior in clear cell renal cell carcinoma
Biomark Med, 12 (1), 45-61
DOI 10.2217/bmm-2017-0142, PubMed 29243496
Østrup O, Dagenborg VJ, Rødland EA, Skarpeteig V, Silwal-Pandit L, Grzyb K, Berstad AE, Fretland ÅA, Mælandsmo GM, Børresen-Dale AL, Ree AH, Edwin B, Nygaard V, Flatmark K (2017)
Molecular signatures reflecting microenvironmental metabolism and chemotherapy-induced immunogenic cell death in colorectal liver metastases
Oncotarget, 8 (44), 76290-76304
DOI 10.18632/oncotarget.19350, PubMed 29100312
Øverbye A, Holsæter AM, Markus F, Škalko-Basnet N, Iversen TG, Torgersen ML, Sønstevold T, Engebraaten O, Flatmark K, Mælandsmo GM, Skotland T, Sandvig K (2017)
Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide
Oncotarget, 8 (44), 76921-76934
DOI 10.18632/oncotarget.20217, PubMed 29100358

Publications 2016

Alonso A, Nunes-Xavier CE, Bayón Y, Pulido R (2016)
The Extended Family of Protein Tyrosine Phosphatases
Methods Mol Biol, 1447, 1-23
DOI 10.1007/978-1-4939-3746-2_1, PubMed 27514797
Alver TN, Lavelle TJ, Longva AS, Øy GF, Hovig E, Bøe SL (2016)
MITF depletion elevates expression levels of ERBB3 receptor and its cognate ligand NRG1-beta in melanoma
Oncotarget, 7 (34), 55128-55140
DOI 10.18632/oncotarget.10422, PubMed 27391157
Arstad C, Refinetti P, Warren D, Giercksky KE, Ekstrøm PO (2016)
Scanning the mitochondrial genome for mutations by cycling temperature capillary electrophoresis
Mitochondrial DNA A DNA Mapp Seq Anal, 29 (1), 19-30
DOI 10.1080/24701394.2016.1233532, PubMed 27728990
Bachmann L, Fromm B, Patella de Azambuja L, Boeger WA (2016)
The mitochondrial genome of the egg-laying flatworm Aglaiogyrodactylus forficulatus (Platyhelminthes: Monogenoidea)
Parasit Vectors, 9 (1), 285
DOI 10.1186/s13071-016-1586-2, PubMed 27188228
Ballinger ML, Goode DL, Ray-Coquard I, James PA, Mitchell G, Niedermayr E, Puri A, Schiffman JD, Dite GS, Cipponi A, Maki RG, Brohl AS, Myklebost O, Stratford EW, Lorenz S, Ahn SM, Ahn JH, Kim JE, Shanley S, Beshay V, Randall RL, Judson I, Seddon B, Campbell IG, Young MA et al. (2016)
Monogenic and polygenic determinants of sarcoma risk: an international genetic study
Lancet Oncol, 17 (9), 1261-71
DOI 10.1016/S1470-2045(16)30147-4, PubMed 27498913
Barøy T, Chilamakuri CS, Lorenz S, Sun J, Bruland ØS, Myklebost O, Meza-Zepeda LA (2016)
Genome Analysis of Osteosarcoma Progression Samples Identifies FGFR1 Overexpression as a Potential Treatment Target and CHM as a Candidate Tumor Suppressor Gene
PLoS One, 11 (9), e0163859
DOI 10.1371/journal.pone.0163859, PubMed 27685995
Björklund AT, Clancy T, Goodridge JP, Béziat V, Schaffer M, Hovig E, Ljunggren HG, Ljungman PT, Malmberg KJ (2016)
Naive Donor NK Cell Repertoires Associated with Less Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation
J Immunol, 196 (3), 1400-11
DOI 10.4049/jimmunol.1501434, PubMed 26746188
Boye K, Jacob H, Frikstad KA, Nesland JM, Maelandsmo GM, Dahl O, Nesbakken A, Flatmark K (2016)
Prognostic significance of S100A4 expression in stage II and III colorectal cancer: results from a population-based series and a randomized phase III study on adjuvant chemotherapy
Cancer Med, 5 (8), 1840-9
DOI 10.1002/cam4.766, PubMed 27273130
Braadland PR, Grytli HH, Ramberg H, Katz B, Kellman R, Gauthier-Landry L, Fazli L, Krobert KA, Wang W, Levy FO, Bjartell A, Berge V, Rennie PS, Mellgren G, Mælandsmo GM, Svindland A, Barbier O, Taskén KA (2016)
Low β₂-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism
Oncotarget, 7 (2), 1878-94
DOI 10.18632/oncotarget.6479, PubMed 26646591
Børnich C, Grytten I, Hovig E, Paulsen J, Čech M, Sandve GK (2016)
Galaxy Portal: interacting with the galaxy platform through mobile devices
Bioinformatics, 32 (11), 1743-5
DOI 10.1093/bioinformatics/btw042, PubMed 26819474
Clancy T, Hovig E (2016)
Profiling networks of distinct immune-cells in tumors
BMC Bioinformatics, 17 (1), 263
DOI 10.1186/s12859-016-1141-3, PubMed 27377892
DA Silva FC, Wernhoff P, Dominguez-Barrera C, Dominguez-Valentin M (2016)
Update on Hereditary Colorectal Cancer
Anticancer Res, 36 (9), 4399-405
DOI 10.21873/anticanres.10983, PubMed 27630275
Dahl JA, Jung I, Aanes H, Greggains GD, Manaf A, Lerdrup M, Li G, Kuan S, Li B, Lee AY, Preissl S, Jermstad I, Haugen MH, Suganthan R, Bjørås M, Hansen K, Dalen KT, Fedorcsak P, Ren B, Klungland A (2016)
Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition
Nature, 537 (7621), 548-552
DOI 10.1038/nature19360, PubMed 27626377
Di Stefano M, Paulsen J, Lien TG, Hovig E, Micheletti C (2016)
Hi-C-constrained physical models of human chromosomes recover functionally-related properties of genome organization
Sci Rep, 6, 35985
DOI 10.1038/srep35985, PubMed 27786255
Dominguez-Valentin M, Wernhoff P, Cajal AR, Kalfayan PG, Piñero TA, Gonzalez ML, Ferro A, Sammartino I, Causada Calo NS, Vaccaro CA (2016)
MLH1 Ile219Val Polymorphism in Argentinean Families with Suspected Lynch Syndrome
Front Oncol, 6, 189
DOI 10.3389/fonc.2016.00189, PubMed 27606285
Dueland S, Ree AH, Grøholt KK, Saelen MG, Folkvord S, Hole KH, Seierstad T, Larsen SG, Giercksky KE, Wiig JN, Boye K, Flatmark K (2016)
Oxaliplatin-containing Preoperative Therapy in Locally Advanced Rectal Cancer: Local Response, Toxicity and Long-term Outcome
Clin Oncol (R Coll Radiol), 28 (8), 532-9
DOI 10.1016/j.clon.2016.01.014, PubMed 26888115
Egeland EV, Flatmark K, Nesland JM, Flørenes VA, Mælandsmo GM, Boye K (2016)
Expression and clinical significance of Wee1 in colorectal cancer
Tumour Biol, 37 (9), 12133-12140
DOI 10.1007/s13277-016-5081-3, PubMed 27220319
Errarte P, Guarch R, Pulido R, Blanco L, Nunes-Xavier CE, Beitia M, Gil J, Angulo JC, López JI, Larrinaga G (2016)
The Expression of Fibroblast Activation Protein in Clear Cell Renal Cell Carcinomas Is Associated with Synchronous Lymph Node Metastases
PLoS One, 11 (12), e0169105
DOI 10.1371/journal.pone.0169105, PubMed 28033421
Evans DG, Harkness EF, Howell A, Wilson M, Hurley E, Holmen MM, Tharmaratnam KU, Hagen AI, Lim Y, Maxwell AJ, Moller P (2016)
Intensive breast screening in BRCA2 mutation carriers is associated with reduced breast cancer specific and all cause mortality
Hered Cancer Clin Pract, 14, 8
DOI 10.1186/s13053-016-0048-3, PubMed 27087880
Evensen L, Johansen PL, Koster G, Zhu K, Herfindal L, Speth M, Fenaroli F, Hildahl J, Bagherifam S, Tulotta C, Prasmickaite L, Mælandsmo GM, Snaar-Jagalska E, Griffiths G (2016)
Zebrafish as a model system for characterization of nanoparticles against cancer
Nanoscale, 8 (2), 862-77
DOI 10.1039/c5nr07289a, PubMed 26648525
Flatmark K, Høye E, Fromm B (2016)
microRNAs as cancer biomarkers
Scand J Clin Lab Invest Suppl, 245, S80-3
DOI 10.1080/00365513.2016.1210330, PubMed 27542003
Flatmark K, Saelen MG, Hole KH, Abrahamsen TW, Fleten KG, Hektoen HH, Redalen KR, Seierstad T, Dueland S, Ree AH (2016)
Individual tumor volume responses to short-course oxaliplatin-containing induction chemotherapy in locally advanced rectal cancer - Targeting the tumor for radiation sensitivity?
Radiother Oncol, 119 (3), 505-11
DOI 10.1016/j.radonc.2016.02.020, PubMed 26968754
Fleten KG, Bakke KM, Mælandsmo GM, Abildgaard A, Redalen KR, Flatmark K (2016)
Use of non-invasive imaging to monitor response to aflibercept treatment in murine models of colorectal cancer liver metastases
Clin Exp Metastasis, 34 (1), 51-62
DOI 10.1007/s10585-016-9829-3, PubMed 27812769
Fleten KG, Flørenes VA, Prasmickaite L, Hill O, Sykora J, Mælandsmo GM, Engesæter B (2016)
hvTRA, a novel TRAIL receptor agonist, induces apoptosis and sustained growth retardation in melanoma
Cell Death Discov, 2, 16081
DOI 10.1038/cddiscovery.2016.81, PubMed 28028438
Frøysnes IS, Larsen SG, Spasojevic M, Dueland S, Flatmark K (2016)
Complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastasis in Norway: Prognostic factors and oncologic outcome in a national patient cohort
J Surg Oncol, 114 (2), 222-7
DOI 10.1002/jso.24290, PubMed 27173150
Halvorsen AR, Silwal-Pandit L, Meza-Zepeda LA, Vodak D, Vu P, Sagerup C, Hovig E, Myklebost O, Børresen-Dale AL, Brustugun OT, Helland Å (2016)
TP53 Mutation Spectrum in Smokers and Never Smoking Lung Cancer Patients
Front Genet, 7, 85
DOI 10.3389/fgene.2016.00085, PubMed 27242894
Hanes R, Grad I, Lorenz S, Stratford EW, Munthe E, Reddy CC, Meza-Zepeda LA, Myklebost O (2016)
Preclinical evaluation of potential therapeutic targets in dedifferentiated liposarcoma
Oncotarget, 7 (34), 54583-54595
DOI 10.18632/oncotarget.10518, PubMed 27409346
Haugvik SP, Vodák D, Haugom L, Hovig E, Gladhaug IP, Heim S, Micci F (2016)
Transcriptomic Profiling of Tumor Aggressiveness in Sporadic Nonfunctioning Pancreatic Neuroendocrine Neoplasms
Pancreas, 45 (8), 1196-203
DOI 10.1097/MPA.0000000000000610, PubMed 26918873
Hetland G, Eide DM, Tangen JM, Haugen MH, Mirlashari MR, Paulsen JE (2016)
The Agaricus blazei-Based Mushroom Extract, Andosan™, Protects against Intestinal Tumorigenesis in the A/J Min/+ Mouse
PLoS One, 11 (12), e0167754
DOI 10.1371/journal.pone.0167754, PubMed 28002446
Hompland I, Bruland ØS, Ubhayasekhera K, Bergquist J, Boye K (2016)
Clinical implications of repeated drug monitoring of imatinib in patients with metastatic gastrointestinal stromal tumour
Clin Sarcoma Res, 6, 21
DOI 10.1186/s13569-016-0062-2, PubMed 27999655
Haakensen VD, Nygaard V, Greger L, Aure MR, Fromm B, Bukholm IR, Lüders T, Chin SF, Git A, Caldas C, Kristensen VN, Brazma A, Børresen-Dale AL, Hovig E, Helland Å (2016)
Subtype-specific micro-RNA expression signatures in breast cancer progression
Int J Cancer, 139 (5), 1117-28
DOI 10.1002/ijc.30142, PubMed 27082076
Itkonen HM, Gorad SS, Duveau DY, Martin SE, Barkovskaya A, Bathen TF, Moestue SA, Mills IG (2016)
Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism
Oncotarget, 7 (11), 12464-76
DOI 10.18632/oncotarget.7039, PubMed 26824323
Jonsson M, Ragnum HB, Julin CH, Yeramian A, Clancy T, Frikstad KM, Seierstad T, Stokke T, Matias-Guiu X, Ree AH, Flatmark K, Lyng H (2016)
Hypoxia-independent gene expression signature associated with radiosensitisation of prostate cancer cell lines by histone deacetylase inhibition
Br J Cancer, 115 (8), 929-939
DOI 10.1038/bjc.2016.278, PubMed 27599042
Joshi S, Schjølberg AR, Ekstrøm PO, De Angelis PM, Zucknick M, Andersen SN, Clausen OP (2016)
Tp53/p53 status in keratoacanthomas
J Cutan Pathol, 43 (7), 571-8
DOI 10.1111/cup.12713, PubMed 27020606
Kalanxhi E, Hektoen HH, Meltzer S, Dueland S, Flatmark K, Ree AH (2016)
Circulating proteins in response to combined-modality therapy in rectal cancer identified by antibody array screening
BMC Cancer, 16, 536
DOI 10.1186/s12885-016-2601-x, PubMed 27461255
Kalanxhi E, Risberg K, Barua IS, Dueland S, Waagene S, Andersen SN, Pettersen SJ, Lindvall JM, Redalen KR, Flatmark K, Ree AH (2016)
Induction of Apoptosis in Intestinal Toxicity to a Histone Deacetylase Inhibitor in a Phase I Study with Pelvic Radiotherapy
Cancer Res Treat, 49 (2), 374-386
DOI 10.4143/crt.2016.080, PubMed 27488871
Kim E, Kim J, Maelandsmo GM, Johansen B, Moestue SA (2016)
Anti-angiogenic therapy affects the relationship between tumor vascular structure and function: A correlation study between micro-computed tomography angiography and dynamic contrast enhanced MRI
Magn Reson Med, 78 (4), 1513-1522
DOI 10.1002/mrm.26547, PubMed 27888545
Kim E, Tunset HM, Cebulla J, Vettukattil R, Helgesen H, Feuerherm AJ, Engebråten O, Mælandsmo GM, Johansen B, Moestue SA (2016)
Anti-vascular effects of the cytosolic phospholipase A2 inhibitor AVX235 in a patient-derived basal-like breast cancer model
BMC Cancer, 16, 191
DOI 10.1186/s12885-016-2225-1, PubMed 26951085
Kongsgaard A, Boye K, Fodstad Ø, Juell S, Jørgensen LH, Solberg S, Helland Å, Brustugun OT, Mælandsmo GM (2016)
Detection of disseminated tumor cells in lymph nodes from patients with early stage non-small cell lung cancer
Diagn Pathol, 11 (1), 50
DOI 10.1186/s13000-016-0504-4, PubMed 27316334
Kotsopoulos J, Huzarski T, Gronwald J, Moller P, Lynch HT, Neuhausen SL, Senter L, Demsky R, Foulkes WD, Eng C, Karlan B, Tung N, Singer CF, Sun P, Lubinski J, Narod SA (2016)
Hormone replacement therapy after menopause and risk of breast cancer in BRCA1 mutation carriers: a case-control study
Breast Cancer Res Treat, 155 (2), 365-73
DOI 10.1007/s10549-016-3685-3, PubMed 26780555
Kotsopoulos J, Huzarski T, Gronwald J, Singer CF, Moller P, Lynch HT, Armel S, Karlan B, Foulkes WD, Neuhausen SL, Senter L, Tung N, Weitzel JN, Eisen A, Metcalfe K, Eng C, Pal T, Evans G, Sun P, Lubinski J, Narod SA, Hereditary Breast Cancer Clinical Study Group (2016)
Bilateral Oophorectomy and Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
J Natl Cancer Inst, 109 (1)
DOI 10.1093/jnci/djw177, PubMed 27601060
Landfors M, Nakken S, Fusser M, Dahl JA, Klungland A, Fedorcsak P (2016)
Sequencing of FTO and ALKBH5 in men undergoing infertility work-up identifies an infertility-associated variant and two missense mutations
Fertil Steril, 105 (5), 1170-1179.e5
DOI 10.1016/j.fertnstert.2016.01.002, PubMed 26820768
Lim S, Liu H, Madeira da Silva L, Arora R, Liu Z, Phillips JB, Schmitt DC, Vu T, McClellan S, Lin Y, Lin W, Piazza GA, Fodstad O, Tan M (2016)
Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α
Cancer Res, 76 (8), 2231-42
DOI 10.1158/0008-5472.CAN-15-1538, PubMed 27197253
Lindstad T, Qu S, Sikkeland J, Jin Y, Kristian A, Mælandsmo GM, Collas P, Saatcioglu F (2016)
STAMP2 is required for human adipose-derived stem cell differentiation and adipocyte-facilitated prostate cancer growth in vivo
Oncotarget, 8 (54), 91817-91827
DOI 10.18632/oncotarget.11131, PubMed 29190878
Lorenz S, Barøy T, Sun J, Nome T, Vodák D, Bryne JC, Håkelien AM, Fernandez-Cuesta L, Möhlendick B, Rieder H, Szuhai K, Zaikova O, Ahlquist TC, Thomassen GO, Skotheim RI, Lothe RA, Tarpey PS, Campbell P, Flanagan A, Myklebost O, Meza-Zepeda LA (2016)
Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations
Oncotarget, 7 (5), 5273-88
DOI 10.18632/oncotarget.6567, PubMed 26672768
Meltzer S, Kalanxhi E, Hektoen HH, Dueland S, Flatmark K, Redalen KR, Ree AH (2016)
Systemic release of osteoprotegerin during oxaliplatin-containing induction chemotherapy and favorable systemic outcome of sequential radiotherapy in rectal cancer
Oncotarget, 7 (23), 34907-17
DOI 10.18632/oncotarget.8995, PubMed 27145458
Moen LV, Ramberg H, Zhao S, Grytli HH, Sveen A, Berge V, Skotheim RI, Taskén KA, Skålhegg BS (2016)
Observed correlation between the expression levels of catalytic subunit, Cβ2, of cyclic adenosine monophosphate-dependent protein kinase and prostate cancer aggressiveness
Urol Oncol, 35 (3), 111.e1-111.e8
DOI 10.1016/j.urolonc.2016.10.002, PubMed 27838142
Munthe E, Riss PJ, Saga TA, Haraldsen I, Grad I, Bogsrud TV, Bach-Gansmo T (2016)
FDG-based quantitative comparison of glucose metabolism in vitro, exemplified by a head-to-head comparison between a triple-negative breast cancer cell line and a non-malignant foetal cell line
Clin Physiol Funct Imaging, 38 (1), 34-37
DOI 10.1111/cpf.12378, PubMed 27297457
Møller P, Seppälä T, Bernstein I, Holinski-Feder E, Sala P, Evans DG, Lindblom A, Macrae F, Blanco I, Sijmons R, Jeffries J, Vasen H, Burn J, Nakken S, Hovig E, Rødland EA, Tharmaratnam K, de Vos Tot Nederveen Cappel WH, Hill J, Wijnen J, Jenkins M, Green K, Lalloo F, Sunde L, Mints M et al. (2016)
Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database
Gut, 66 (9), 1657-1664
DOI 10.1136/gutjnl-2016-311403, PubMed 27261338
Nunes-Xavier CE, Karlsen KF, Tekle C, Pedersen C, Øyjord T, Hongisto V, Nesland JM, Tan M, Sahlberg KK, Fodstad Ø (2016)
Decreased expression of B7-H3 reduces the glycolytic capacity and sensitizes breast cancer cells to AKT/mTOR inhibitors
Oncotarget, 7 (6), 6891-901
DOI 10.18632/oncotarget.6902, PubMed 26771843
Nunes-Xavier CE, Pulido R (2016)
Global RT-PCR and RT-qPCR Analysis of the mRNA Expression of the Human PTPome
Methods Mol Biol, 1447, 25-37
DOI 10.1007/978-1-4939-3746-2_2, PubMed 27514798
Ramalho-Carvalho J, Fromm B, Henrique R, Jerónimo C (2016)
Deciphering the function of non-coding RNAs in prostate cancer
Cancer Metastasis Rev, 35 (2), 235-62
DOI 10.1007/s10555-016-9628-y, PubMed 27221068
Ramberg H, Grytli HH, Nygård S, Wang W, Ögren O, Zhao S, Løvf M, Katz B, Skotheim RI, Bjartell A, Eri LM, Berge V, Svindland A, Taskén KA (2016)
PBX3 is a putative biomarker of aggressive prostate cancer
Int J Cancer, 139 (8), 1810-20
DOI 10.1002/ijc.30220, PubMed 27273830
Refinetti P, Morgenthaler S, Ekstrøm PO (2016)
Cycling temperature capillary electrophoresis: A quantitative, fast and inexpensive method to detect mutations in mixed populations of human mitochondrial DNA
Mitochondrion, 29, 65-74
DOI 10.1016/j.mito.2016.04.006, PubMed 27166160
Safavi S, Järnum S, Vannas C, Udhane S, Jonasson E, Tomic TT, Grundevik P, Fagman H, Hansson M, Kalender Z, Jauhiainen A, Dolatabadi S, Stratford EW, Myklebost O, Eriksson M, Stenman G, Schneider-Stock R, Ståhlberg A, Åman P (2016)
HSP90 inhibition blocks ERBB3 and RET phosphorylation in myxoid/round cell liposarcoma and causes massive cell death in vitro and in vivo
Oncotarget, 7 (1), 433-45
DOI 10.18632/oncotarget.6336, PubMed 26595521
Sandhu V, Wedge DC, Bowitz Lothe IM, Labori KJ, Dentro SC, Buanes T, Skrede ML, Dalsgaard AM, Munthe E, Myklebost O, Lingjærde OC, Børresen-Dale AL, Ikdahl T, Van Loo P, Nord S, Kure EH (2016)
The Genomic Landscape of Pancreatic and Periampullary Adenocarcinoma
Cancer Res, 76 (17), 5092-102
DOI 10.1158/0008-5472.CAN-16-0658, PubMed 27488532
Seip K, Fleten KG, Barkovskaya A, Nygaard V, Haugen MH, Engesæter BØ, Mælandsmo GM, Prasmickaite L (2016)
Fibroblast-induced switching to the mesenchymal-like phenotype and PI3K/mTOR signaling protects melanoma cells from BRAF inhibitors
Oncotarget, 7 (15), 19997-20015
DOI 10.18632/oncotarget.7671, PubMed 26918352
Späth F, Andersson U, Dahlin AM, Langseth H, Hovig E, Johannesen TB, Grankvist K, Björkblom B, Wibom C, Melin B (2016)
Pre-diagnostic serum levels of EGFR and ErbB2 and genetic glioma risk variants: a nested case-control study
Tumour Biol, 37 (8), 11065-72
DOI 10.1007/s13277-015-4742-y, PubMed 26906551
Thorgersen EB, Goscinski MA, Spasojevic M, Solbakken AM, Mariathasan AB, Boye K, Larsen SG, Flatmark K (2016)
Deep Pelvic Surgical Site Infection After Radiotherapy and Surgery for Locally Advanced Rectal Cancer
Ann Surg Oncol, 24 (3), 721-728
DOI 10.1245/s10434-016-5621-5, PubMed 27766561
Vaccaro CA, Sarroca C, Rossi B, Lopez-Kostner F, Dominguez M, Calo NC, Cutait R, Valle AD, Nuñez L, Neffa F, Alvarez K, Gonzalez ML, Kalfayan P, Lynch HT, Church J (2016)
Lynch syndrome in South America: past, present and future
Fam Cancer, 15 (3), 437-45
DOI 10.1007/s10689-016-9903-7, PubMed 27007491
Våtsveen TK, Børset M, Dikic A, Tian E, Micci F, Lid AH, Meza-Zepeda LA, Coward E, Waage A, Sundan A, Kuehl WM, Holien T (2016)
VOLIN and KJON-Two novel hyperdiploid myeloma cell lines
Genes Chromosomes Cancer, 55 (11), 890-901
DOI 10.1002/gcc.22388, PubMed 27311012
Westrøm S, Bønsdorff TB, Abbas N, Bruland ØS, Jonasdottir TJ, Mælandsmo GM, Larsen RH (2016)
Evaluation of CD146 as Target for Radioimmunotherapy against Osteosarcoma
PLoS One, 11 (10), e0165382
DOI 10.1371/journal.pone.0165382, PubMed 27776176
Ylla G, Fromm B, Piulachs MD, Belles X (2016)
The microRNA toolkit of insects
Sci Rep, 6, 37736
DOI 10.1038/srep37736, PubMed 27883064

Publications 2015

Alioto TS, Buchhalter I, Derdak S, Hutter B, Eldridge MD, Hovig E, Heisler LE, Beck TA, Simpson JT, Tonon L, Sertier AS, Patch AM, Jäger N, Ginsbach P, Drews R, Paramasivam N, Kabbe R, Chotewutmontri S, Diessl N, Previti C, Schmidt S, Brors B, Feuerbach L, Heinold M, Gröbner S et al. (2015)
A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing
Nat Commun, 6, 10001
DOI 10.1038/ncomms10001, PubMed 26647970
Almåsbak H, Walseng E, Kristian A, Myhre MR, Suso EM, Munthe LA, Andersen JT, Wang MY, Kvalheim G, Gaudernack G, Kyte JA (2015)
Inclusion of an IgG1-Fc spacer abrogates efficacy of CD19 CAR T cells in a xenograft mouse model
Gene Ther, 22 (5), 391-403
DOI 10.1038/gt.2015.4, PubMed 25652098
Andersson Y, Engebraaten O, Juell S, Aamdal S, Brunsvig P, Fodstad Ø, Dueland S (2015)
Phase I trial of EpCAM-targeting immunotoxin MOC31PE, alone and in combination with cyclosporin
Br J Cancer, 113 (11), 1548-55
DOI 10.1038/bjc.2015.380, PubMed 26554649
Aure MR, Jernström S, Krohn M, Vollan HK, Due EU, Rødland E, Kåresen R, Oslo Breast Cancer Research Consortium (OSBREAC), Ram P, Lu Y, Mills GB, Sahlberg KK, Børresen-Dale AL, Lingjærde OC, Kristensen VN (2015)
Integrated analysis reveals microRNA networks coordinately expressed with key proteins in breast cancer
Genome Med, 7 (1), 21
DOI 10.1186/s13073-015-0135-5, PubMed 25873999
Bengtsen M, Klepper K, Gundersen S, Cuervo I, Drabløs F, Hovig E, Sandve GK, Gabrielsen OS, Eskeland R (2015)
c-Myb Binding Sites in Haematopoietic Chromatin Landscapes
PLoS One, 10 (7), e0133280
DOI 10.1371/journal.pone.0133280, PubMed 26208222
Bettum IJ, Gorad SS, Barkovskaya A, Pettersen S, Moestue SA, Vasiliauskaite K, Tenstad E, Øyjord T, Risa Ø, Nygaard V, Mælandsmo GM, Prasmickaite L (2015)
Metabolic reprogramming supports the invasive phenotype in malignant melanoma
Cancer Lett, 366 (1), 71-83
DOI 10.1016/j.canlet.2015.06.006, PubMed 26095603
Braadland PR, Ramberg H, Grytli HH, Taskén KA (2015)
β-Adrenergic Receptor Signaling in Prostate Cancer
Front Oncol, 4, 375
DOI 10.3389/fonc.2014.00375, PubMed 25629002
Christiansen IK, Sandve GK, Schmitz M, Dürst M, Hovig E (2015)
Transcriptionally active regions are the preferred targets for chromosomal HPV integration in cervical carcinogenesis
PLoS One, 10 (3), e0119566
DOI 10.1371/journal.pone.0119566, PubMed 25793388
Chymkowitch P, Nguéa AP, Aanes H, Koehler CJ, Thiede B, Lorenz S, Meza-Zepeda LA, Klungland A, Enserink JM (2015)
Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes
Genome Res, 25 (6), 897-906
DOI 10.1101/gr.185793.114, PubMed 25800674
Egeland EV, Boye K, Pettersen SJ, Haugen MH, Øyjord T, Malerød L, Flatmark K, Mælandsmo GM (2015)
Enrichment of nuclear S100A4 during G2/M in colorectal cancer cells: possible association with cyclin B1 and centrosomes
Clin Exp Metastasis, 32 (8), 755-67
DOI 10.1007/s10585-015-9742-1, PubMed 26349943
Eide N, Faye RS, Høifødt HK, Sandstad B, Qvale G, Faber R, Jebsen P, Kvalheim G, Fodstad Ø (2015)
Immunomagnetic detection of micrometastatic cells in bone marrow of uveal melanoma patients: a paradox
Acta Ophthalmol, 93 (1), 59-66
DOI 10.1111/aos.12462, PubMed 25613126
Eide N, Garred Ø, Beiske K, Fodstad Ø (2015)
Bilateral uveal melanomas with different gene expression detected with 7 years interval
Acta Ophthalmol, 94 (1), 99-102
DOI 10.1111/aos.12857, PubMed 26496992
Ekstrøm PO, Nakken S, Johansen M, Hovig E (2015)
Automated amplicon design suitable for analysis of DNA variants by melting techniques
BMC Res Notes, 8, 667
DOI 10.1186/s13104-015-1624-8, PubMed 26559640
Fernandez-Cuesta L, Sun R, Menon R, George J, Lorenz S, Meza-Zepeda LA, Peifer M, Plenker D, Heuckmann JM, Leenders F, Zander T, Dahmen I, Koker M, Schöttle J, Ullrich RT, Altmüller J, Becker C, Nürnberg P, Seidel H, Böhm D, Göke F, Ansén S, Russell PA, Wright GM, Wainer Z et al. (2015)
Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data
Genome Biol, 16 (1), 7
DOI 10.1186/s13059-014-0558-0, PubMed 25650807
Fretland ÅA, Kazaryan AM, Bjørnbeth BA, Flatmark K, Andersen MH, Tønnessen TI, Bjørnelv GM, Fagerland MW, Kristiansen R, Øyri K, Edwin B (2015)
Open versus laparoscopic liver resection for colorectal liver metastases (the Oslo-CoMet Study): study protocol for a randomized controlled trial
Trials, 16, 73
DOI 10.1186/s13063-015-0577-5, PubMed 25872027
Fromm B, Billipp T, Peck LE, Johansen M, Tarver JE, King BL, Newcomb JM, Sempere LF, Flatmark K, Hovig E, Peterson KJ (2015)
A Uniform System for the Annotation of Vertebrate microRNA Genes and the Evolution of the Human microRNAome
Annu Rev Genet, 49, 213-42
DOI 10.1146/annurev-genet-120213-092023, PubMed 26473382
Fromm B, Trelis M, Hackenberg M, Cantalapiedra F, Bernal D, Marcilla A (2015)
The revised microRNA complement of Fasciola hepatica reveals a plethora of overlooked microRNAs and evidence for enrichment of immuno-regulatory microRNAs in extracellular vesicles
Int J Parasitol, 45 (11), 697-702
DOI 10.1016/j.ijpara.2015.06.002, PubMed 26183562
Hektoen HH, Flatmark K, Andersson Y, Dueland S, Redalen KR, Ree AH (2015)
Early increase in circulating carbonic anhydrase IX during neoadjuvant treatment predicts favourable outcome in locally advanced rectal cancer
BMC Cancer, 15, 543
DOI 10.1186/s12885-015-1557-6, PubMed 26205955
Hektoen HH, Ree AH, Redalen KR, Flatmark K (2015)
Sulfamate inhibitor S4 influences carbonic anhydrase IX ectodomain shedding in colorectal carcinoma cells
J Enzyme Inhib Med Chem, 31 (5), 779-86
DOI 10.3109/14756366.2015.1069286, PubMed 26244271
Heramb C, Ekstrøm PO, Tharmaratnam K, Hovig E, Møller P, Mæhle L (2015)
Ten modifiers of BRCA1 penetrance validated in a Norwegian series
Hered Cancer Clin Pract, 13 (1), 14
DOI 10.1186/s13053-015-0035-0, PubMed 26052370
Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Tesic Mark M, Molina H, Kohsaka S, Di Giannatale A, Ceder S, Singh S, Williams C, Soplop N, Uryu K, Pharmer L, King T, Bojmar L, Davies AE, Ararso Y, Zhang T, Zhang H, Hernandez J, Weiss JM, Dumont-Cole VD, Kramer K et al. (2015)
Tumour exosome integrins determine organotropic metastasis
Nature, 527 (7578), 329-35
DOI 10.1038/nature15756, PubMed 26524530
Ingthorsson S, Andersen K, Hilmarsdottir B, Maelandsmo GM, Magnusson MK, Gudjonsson T (2015)
HER2 induced EMT and tumorigenicity in breast epithelial progenitor cells is inhibited by coexpression of EGFR
Oncogene, 35 (32), 4244-55
DOI 10.1038/onc.2015.489, PubMed 26686087
Ishibashi M, Manning E, Shoubridge C, Krecsmarik M, Hawkins TA, Giacomotto J, Zhao T, Mueller T, Bader PI, Cheung SW, Stankiewicz P, Bain NL, Hackett A, Reddy CC, Mechaly AS, Peers B, Wilson SW, Lenhard B, Bally-Cuif L, Gecz J, Becker TS, Rinkwitz S (2015)
Copy number variants in patients with intellectual disability affect the regulation of ARX transcription factor gene
Hum Genet, 134 (11-12), 1163-82
DOI 10.1007/s00439-015-1594-x, PubMed 26337422
Jin Y, Wang L, Qu S, Sheng X, Kristian A, Mælandsmo GM, Pällmann N, Yuca E, Tekedereli I, Gorgulu K, Alpay N, Sood A, Lopez-Berestein G, Fazli L, Rennie P, Risberg B, Wæhre H, Danielsen HE, Ozpolat B, Saatcioglu F (2015)
STAMP2 increases oxidative stress and is critical for prostate cancer
EMBO Mol Med, 7 (3), 315-31
DOI 10.15252/emmm.201404181, PubMed 25680860
Ju YS, Tubio JM, Mifsud W, Fu B, Davies HR, Ramakrishna M, Li Y, Yates L, Gundem G, Tarpey PS, Behjati S, Papaemmanuil E, Martin S, Fullam A, Gerstung M, ICGC Prostate Cancer Working Group, ICGC Bone Cancer Working Group, ICGC Breast Cancer Working Group, Nangalia J, Green AR, Caldas C, Borg Å, Tutt A, Lee MT, van't Veer LJ et al. (2015)
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
Genome Res, 25 (6), 814-24
DOI 10.1101/gr.190470.115, PubMed 25963125
Kanojia D, Nagata Y, Garg M, Lee DH, Sato A, Yoshida K, Sato Y, Sanada M, Mayakonda A, Bartenhagen C, Klein HU, Doan NB, Said JW, Mohith S, Gunasekar S, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Myklebost O, Yang H, Dugas M, Meza-Zepeda LA, Silberman AW, Forscher C et al. (2015)
Genomic landscape of liposarcoma
Oncotarget, 6 (40), 42429-44
DOI 10.18632/oncotarget.6464, PubMed 26643872
Lau C, Nygård S, Fure H, Olstad OK, Holden M, Lappegård KT, Brekke OL, Espevik T, Hovig E, Mollnes TE (2015)
CD14 and complement crosstalk and largely mediate the transcriptional response to Escherichia coli in human whole blood as revealed by DNA microarray
PLoS One, 10 (2), e0117261
DOI 10.1371/journal.pone.0117261, PubMed 25706641
Lau C, Olstad OK, Holden M, Nygård S, Fure H, Lappegård KT, Brekke OL, Espevik T, Hovig E, Mollnes TE (2015)
Gene expression profiling of Gram-negative bacteria-induced inflammation in human whole blood: The role of complement and CD14-mediated innate immune response
Genom Data, 5, 176-83
DOI 10.1016/j.gdata.2015.05.019, PubMed 26484252
Magnussen GI, Emilsen E, Giller Fleten K, Engesæter B, Nähse-Kumpf V, Fjær R, Slipicevic A, Flørenes VA (2015)
Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma
BMC Cancer, 15, 462
DOI 10.1186/s12885-015-1474-8, PubMed 26054341
Myklebost O (2015)
Personalized cancer therapy for soft tissue sarcomas: progress and pitfalls
Per Med, 12 (6), 593-602
DOI 10.2217/pme.15.20, PubMed 29750616
Møller P, Seppälä T, Bernstein I, Holinski-Feder E, Sala P, Evans DG, Lindblom A, Macrae F, Blanco I, Sijmons R, Jeffries J, Vasen H, Burn J, Nakken S, Hovig E, Rødland EA, Tharmaratnam K, de Vos Tot Nederveen Cappel WH, Hill J, Wijnen J, Green K, Lalloo F, Sunde L, Mints M, Bertario L et al. (2015)
Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database
Gut, 66 (3), 464-472
DOI 10.1136/gutjnl-2015-309675, PubMed 26657901
Naderi EH, Skah S, Ugland H, Myklebost O, Sandnes DL, Torgersen ML, Josefsen D, Ruud E, Naderi S, Blomhoff HK (2015)
Bone marrow stroma-derived PGE2 protects BCP-ALL cells from DNA damage-induced p53 accumulation and cell death
Mol Cancer, 14 (1), 14
DOI 10.1186/s12943-014-0278-9, PubMed 25623255
Naville M, Ishibashi M, Ferg M, Bengani H, Rinkwitz S, Krecsmarik M, Hawkins TA, Wilson SW, Manning E, Chilamakuri CS, Wilson DI, Louis A, Lucy Raymond F, Rastegar S, Strähle U, Lenhard B, Bally-Cuif L, van Heyningen V, FitzPatrick DR, Becker TS, Roest Crollius H (2015)
Long-range evolutionary constraints reveal cis-regulatory interactions on the human X chromosome
Nat Commun, 6, 6904
DOI 10.1038/ncomms7904, PubMed 25908307
Nygaard V, Rødland EA, Hovig E (2015)
Methods that remove batch effects while retaining group differences may lead to exaggerated confidence in downstream analyses
Biostatistics, 17 (1), 29-39
DOI 10.1093/biostatistics/kxv027, PubMed 26272994
Pitman KE, Rusten E, Kristian A, Malinen E (2015)
Variability of dynamic 18F-FDG-PET data in breast cancer xenografts
Acta Oncol, 54 (9), 1399-407
DOI 10.3109/0284186X.2015.1062140, PubMed 26217987
Prasmickaite L, Berge G, Bettum IJ, Aamdal S, Hansson J, Bastholt L, Øijordsbakken M, Boye K, Mælandsmo GM (2015)
Evaluation of serum osteopontin level and gene polymorphism as biomarkers: analyses from the Nordic Adjuvant Interferon alpha Melanoma trial
Cancer Immunol Immunother, 64 (6), 769-76
DOI 10.1007/s00262-015-1686-4, PubMed 25832001
Redalen KR, Sitter B, Bathen TF, Grøholt KK, Hole KH, Dueland S, Flatmark K, Ree AH, Seierstad T (2015)
High tumor glycine concentration is an adverse prognostic factor in locally advanced rectal cancer
Radiother Oncol, 118 (2), 393-8
DOI 10.1016/j.radonc.2015.11.031, PubMed 26705680
Ree AH, Flatmark K, Saelen MG, Folkvord S, Dueland S, Geisler J, Redalen KR (2015)
Tumor phosphatidylinositol 3-kinase signaling in therapy resistance and metastatic dissemination of rectal cancer: opportunities for signaling-adapted therapies
Crit Rev Oncol Hematol, 95 (1), 114-24
DOI 10.1016/j.critrevonc.2015.01.003, PubMed 25624177
Repetto-Llamazares AH, Larsen RH, Patzke S, Fleten KG, Didierlaurent D, Pichard A, Pouget JP, Dahle J (2015)
Targeted Cancer Therapy with a Novel Anti-CD37 Beta-Particle Emitting Radioimmunoconjugate for Treatment of Non-Hodgkin Lymphoma
PLoS One, 10 (6), e0128816
DOI 10.1371/journal.pone.0128816, PubMed 26066655
Rizos E, Siafakas N, Katsantoni E, Skourti E, Salpeas V, Rizos I, Tsoporis JN, Kastania A, Filippopoulou A, Xiros N, Margaritis D, Parker TG, Papageorgiou C, Zoumpourlis V (2015)
Correction: Let-7, Mir-98 and Mir-181 as Biomarkers for Cancer and Schizophrenia
PLoS One, 10 (8), e0135863
DOI 10.1371/journal.pone.0135863, PubMed 26266816
Rustad EH, Dai HY, Hov H, Coward E, Beisvag V, Myklebost O, Hovig E, Nakken S, Vodák D, Meza-Zepeda LA, Sandvik AK, Wader KF, Misund K, Sundan A, Aarset H, Waage A (2015)
BRAF V600E mutation in early-stage multiple myeloma: good response to broad acting drugs and no relation to prognosis
Blood Cancer J, 5 (3), e299
DOI 10.1038/bcj.2015.24, PubMed 25794135
Rydbeck H, Sandve GK, Ferkingstad E, Simovski B, Rye M, Hovig E (2015)
ClusTrack: feature extraction and similarity measures for clustering of genome-wide data sets
PLoS One, 10 (4), e0123261
DOI 10.1371/journal.pone.0123261, PubMed 25879845
Seierstad T, Hole KH, Grøholt KK, Dueland S, Ree AH, Flatmark K, Redalen KR (2015)
MRI volumetry for prediction of tumour response to neoadjuvant chemotherapy followed by chemoradiotherapy in locally advanced rectal cancer
Br J Radiol, 88 (1051), 20150097
DOI 10.1259/bjr.20150097, PubMed 25899892
Serguienko A, Grad I, Wennerstrøm AB, Meza-Zepeda LA, Thiede B, Stratford EW, Myklebost O, Munthe E (2015)
Metabolic reprogramming of metastatic breast cancer and melanoma by let-7a microRNA
Oncotarget, 6 (4), 2451-65
DOI 10.18632/oncotarget.3235, PubMed 25669981
Skrbo N, Tenstad E, Mælandsmo GM, Sørlie T, Andersen K (2015)
From autonomy to community; new perspectives on tumorigenicity and therapy resistance
Cancer Treat Rev, 41 (10), 809-13
DOI 10.1016/j.ctrv.2015.10.004, PubMed 26519005
Srivastava SK, Bhardwaj A, Arora S, Tyagi N, Singh AP, Carter JE, Scammell JG, Fodstad Ø, Singh S (2015)
Interleukin-8 is a key mediator of FKBP51-induced melanoma growth, angiogenesis and metastasis
Br J Cancer, 112 (11), 1772-81
DOI 10.1038/bjc.2015.154, PubMed 25942396
Tamhane T, Lllukkumbura R, Lu S, Maelandsmo GM, Haugen MH, Brix K (2015)
Nuclear cathepsin L activity is required for cell cycle progression of colorectal carcinoma cells
Biochimie, 122, 208-18
DOI 10.1016/j.biochi.2015.09.003, PubMed 26343556
Tamhane T, Wolters BK, Illukkumbura R, Maelandsmo GM, Haugen MH, Brix K (2015)
Construction of a plasmid coding for green fluorescent protein tagged cathepsin L and data on expression in colorectal carcinoma cells
Data Brief, 5, 468-75
DOI 10.1016/j.dib.2015.09.022, PubMed 26594658
Tran D, Verma K, Ward K, Diaz D, Kataria E, Torabi A, Almeida A, Malfoy B, Stratford EW, Mitchell DC, Bryan BA (2015)
Functional genomics analysis reveals a MYC signature associated with a poor clinical prognosis in liposarcomas
Am J Pathol, 185 (3), 717-28
DOI 10.1016/j.ajpath.2014.11.024, PubMed 25622542
Wendel T, Zhen Y, Suo Z, Bruheim S, Wiedlocha A (2015)
The novel HSP90 inhibitor NVP-AUY922 shows synergistic anti-leukemic activity with cytarabine in vivo
Exp Cell Res, 340 (2), 220-6
DOI 10.1016/j.yexcr.2015.12.017, PubMed 26748184
Wibom C, Späth F, Dahlin AM, Langseth H, Hovig E, Rajaraman P, Johannesen TB, Andersson U, Melin B (2015)
Investigation of established genetic risk variants for glioma in prediagnostic samples from a population-based nested case-control study
Cancer Epidemiol Biomarkers Prev, 24 (5), 810-6
DOI 10.1158/1055-9965.EPI-14-1106, PubMed 25713050
Zhao X, Rødland EA, Tibshirani R, Plevritis S (2015)
Molecular subtyping for clinically defined breast cancer subgroups
Breast Cancer Res, 17 (1), 29
DOI 10.1186/s13058-015-0520-4, PubMed 25849221
Østrup O, Pedersen HS, Holm HM, Hyttel P (2015)
Analysis of nucleolar morphology and protein localization as an indicator of nuclear reprogramming
Methods Mol Biol, 1222, 161-74
DOI 10.1007/978-1-4939-1594-1_12, PubMed 25287345

Publications 2014

Anninga JK, Cleton-Jansen AM, Hassan B, Amary MF, Baumhoer D, Blay JY, Brugieres L, Ferrari S, Jurgens H, Kempf-Bielack B, Kovar H, Myklebost O, Nathrath M, Picci P, Riegman P, Schilham MW, Soliman R, Stark DP, Strauss S, Sydes M, Tarpey P, Thomas D, Whelan J, Wilhelm M, Zamzam M et al. (2014)
Workshop report on the 2nd Joint ENCCA/EuroSARC European bone sarcoma network meeting: integration of clinical trials with tumour biology
Clin. Sarcoma Res., 4, 4
DOI 10.1186/2045-3329-4-4
Bagherifam S, Griffiths GW, Mælandsmo GM, Nyström B, Hasirci V, Hasirci N (2014)
Poly(sebacic anhydride) nanocapsules as carriers: effects of preparation parameters on properties and release of doxorubicin
J Microencapsul, 32 (2), 166-74
DOI 10.3109/02652048.2014.973073, PubMed 25323326
Bagherifam S, Skjeldal FM, Griffiths G, Mælandsmo GM, Engebråten O, Nyström B, Hasirci V, Hasirci N (2014)
pH-responsive nano carriers for doxorubicin delivery
Pharm Res, 32 (4), 1249-63
DOI 10.1007/s11095-014-1530-0, PubMed 25288014
Barøy T, Kresse SH, Skårn M, Stabell M, Castro R, Lauvrak S, Llombart-Bosch A, Myklebost O, Meza-Zepeda LA (2014)
Reexpression of LSAMP inhibits tumor growth in a preclinical osteosarcoma model
Mol Cancer, 13, 93
DOI 10.1186/1476-4598-13-93, PubMed 24885297
Brix K, McInnes J, Al-Hashimi A, Rehders M, Tamhane T, Haugen MH (2014)
Proteolysis mediated by cysteine cathepsins and legumain-recent advances and cell biological challenges
Protoplasma, 252 (3), 755-74
DOI 10.1007/s00709-014-0730-0, PubMed 25398648
Chilamakuri CS, Lorenz S, Madoui MA, Vodák D, Sun J, Hovig E, Myklebost O, Meza-Zepeda LA (2014)
Performance comparison of four exome capture systems for deep sequencing
BMC Genomics, 15 (1), 449
DOI 10.1186/1471-2164-15-449, PubMed 24912484
Clancy T, Hovig E (2014)
From proteomes to complexomes in the era of systems biology
Proteomics, 14 (1), 24-41
DOI 10.1002/pmic.201300230, PubMed 24243660
Clancy T, Hovig E (2014)
Differential protein network analysis of the immune cell lineage
Biomed Res Int, 2014, 363408
DOI 10.1155/2014/363408, PubMed 25309909
Esmaeili M, Moestue SA, Hamans BC, Veltien A, Kristian A, Engebråten O, Maelandsmo GM, Gribbestad IS, Bathen TF, Heerschap A (2014)
In vivo ³¹P magnetic resonance spectroscopic imaging (MRSI) for metabolic profiling of human breast cancer xenografts
J Magn Reson Imaging, 41 (3), 601-9
DOI 10.1002/jmri.24588, PubMed 24532410
Friis-Ottessen M, Burum-Auensen E, Schjølberg AR, Ekstrøm PO, Andersen SN, Clausen OP, De Angelis PM (2014)
TP53/p53 alterations and Aurora A expression in progressor and non-progressor colectomies from patients with longstanding ulcerative colitis
Int J Mol Med, 35 (1), 24-30
DOI 10.3892/ijmm.2014.1974, PubMed 25333414
Garsed DW, Marshall OJ, Corbin VD, Hsu A, Di Stefano L, Schröder J, Li J, Feng ZP, Kim BW, Kowarsky M, Lansdell B, Brookwell R, Myklebost O, Meza-Zepeda L, Holloway AJ, Pedeutour F, Choo KH, Damore MA, Deans AJ, Papenfuss AT, Thomas DM (2014)
The architecture and evolution of cancer neochromosomes
Cancer Cell, 26 (5), 653-67
DOI 10.1016/j.ccell.2014.09.010, PubMed 25517748
Grinde MT, Skrbo N, Moestue SA, Rødland EA, Borgan E, Kristian A, Sitter B, Bathen TF, Børresen-Dale AL, Mælandsmo GM, Engebraaten O, Sørlie T, Marangoni E, Gribbestad IS (2014)
Interplay of choline metabolites and genes in patient-derived breast cancer xenografts
Breast Cancer Res, 16 (1), R5
DOI 10.1186/bcr3597, PubMed 24447408
Haugen MH, Boye K, Nesland JM, Pettersen SJ, Egeland EV, Tamhane T, Brix K, Maelandsmo GM, Flatmark K (2014)
High expression of the cysteine proteinase legumain in colorectal cancer - implications for therapeutic targeting
Eur J Cancer, 51 (1), 9-17
DOI 10.1016/j.ejca.2014.10.020, PubMed 25466510
Hidalgo M, Amant F, Biankin AV, Budinská E, Byrne AT, Caldas C, Clarke RB, de Jong S, Jonkers J, Mælandsmo GM, Roman-Roman S, Seoane J, Trusolino L, Villanueva A (2014)
Patient-derived xenograft models: an emerging platform for translational cancer research
Cancer Discov, 4 (9), 998-1013
DOI 10.1158/2159-8290.CD-14-0001, PubMed 25185190
Håkelien AM, Bryne JC, Harstad KG, Lorenz S, Paulsen J, Sun J, Mikkelsen TS, Myklebost O, Meza-Zepeda LA (2014)
The regulatory landscape of osteogenic differentiation
Stem Cells, 32 (10), 2780-93
DOI 10.1002/stem.1759, PubMed 24898411
Ingebrigtsen VA, Boye K, Nesland JM, Nesbakken A, Flatmark K, Fodstad Ø (2014)
B7-H3 expression in colorectal cancer: associations with clinicopathological parameters and patient outcome
BMC Cancer, 14, 602
DOI 10.1186/1471-2407-14-602, PubMed 25139714
Kristian A, Riss P, Qu H, Milde M, Schoultz BW, Engebraaten O, Mælandsmo GM, Malinen E (2014)
Positron emission tomography and pharmacokinetics of 2-[18F]-fluoroethyl choline for metabolic studies in breast cancer xenografts
Acta Oncol, 53 (8), 1086-92
DOI 10.3109/0284186X.2014.934398, PubMed 25017377
Metsu S, Rooms L, Rainger J, Taylor MS, Bengani H, Wilson DI, Chilamakuri CS, Morrison H, Vandeweyer G, Reyniers E, Douglas E, Thompson G, Haan E, Gecz J, Fitzpatrick DR, Kooy RF (2014)
FRA2A is a CGG repeat expansion associated with silencing of AFF3
PLoS Genet, 10 (4), e1004242
DOI 10.1371/journal.pgen.1004242, PubMed 24763282
Momtazi L, Bagherifam S, Singh G, Hofgaard A, Hakkarainen M, Glomm WR, Roos N, Mælandsmo GM, Griffiths G, Nyström B (2014)
Synthesis, characterization, and cellular uptake of magnetic nanocarriers for cancer drug delivery
J Colloid Interface Sci, 433, 76-85
DOI 10.1016/j.jcis.2014.07.013, PubMed 25112915
Nilsen LB, Fangberget A, Geier OM, Engebraaten O, Borgen E, Olsen DR, Seierstad T (2014)
Associations between tumor vascularization assessed by in vivo DCE-MRI and the presence of disseminated tumor cells in bone marrow in breast cancer patients at the time of diagnosis
J Magn Reson Imaging, 40 (6), 1382-91
DOI 10.1002/jmri.24502, PubMed 24470360
Norum JH, Andersen K, Sørlie T (2014)
Lessons learned from the intrinsic subtypes of breast cancer in the quest for precision therapy
Br J Surg, 101 (8), 925-38
DOI 10.1002/bjs.9562, PubMed 24849143
Nygren MK, Tekle C, Ingebrigtsen VA, Mäkelä R, Krohn M, Aure MR, Nunes-Xavier CE, Perälä M, Tramm T, Alsner J, Overgaard J, Nesland JM, Borgen E, Børresen-Dale AL, Fodstad Ø, Sahlberg KK, Leivonen SK (2014)
Identifying microRNAs regulating B7-H3 in breast cancer: the clinical impact of microRNA-29c
Br J Cancer, 110 (8), 2072-80
DOI 10.1038/bjc.2014.113, PubMed 24577056
Nygård S, Reitan T, Clancy T, Nygaard V, Bjørnstad J, Skrbic B, Tønnessen T, Christensen G, Hovig E (2014)
Identifying pathogenic processes by integrating microarray data with prior knowledge
BMC Bioinformatics, 15, 115
DOI 10.1186/1471-2105-15-115, PubMed 24758699
Nygaard V, Prasmickaite L, Vasiliauskaite K, Clancy T, Hovig E (2014)
Melanoma brain colonization involves the emergence of a brain-adaptive phenotype
Oncoscience, 1 (1), 82-94
DOI 10.18632/oncoscience.11, PubMed 25593989
Ostrup O, Reiner AH, Aleström P, Collas P (2014)
The specific alteration of histone methylation profiles by DZNep during early zebrafish development
Biochim Biophys Acta, 1839 (11), 1307-15
DOI 10.1016/j.bbagrm.2014.09.013, PubMed 25260724
Panagopoulos I, Bjerkehagen B, Gorunova L, Berner JM, Boye K, Heim S (2014)
Several fusion genes identified by whole transcriptome sequencing in a spindle cell sarcoma with rearrangements of chromosome arm 12q and MDM2 amplification
Int J Oncol, 45 (5), 1829-36
DOI 10.3892/ijo.2014.2605, PubMed 25176350
Panagopoulos I, Gorunova L, Bjerkehagen B, Boye K, Heim S (2014)
Chromosome aberrations and HEY1-NCOA2 fusion gene in a mesenchymal chondrosarcoma
Oncol Rep, 32 (1), 40-4
DOI 10.3892/or.2014.3180, PubMed 24839999
Paulsen J, Rødland EA, Holden L, Holden M, Hovig E (2014)
A statistical model of ChIA-PET data for accurate detection of chromatin 3D interactions
Nucleic Acids Res, 42 (18), e143
DOI 10.1093/nar/gku738, PubMed 25114054
Paulsen J, Sandve GK, Gundersen S, Lien TG, Trengereid K, Hovig E (2014)
HiBrowse: multi-purpose statistical analysis of genome-wide chromatin 3D organization
Bioinformatics, 30 (11), 1620-2
DOI 10.1093/bioinformatics/btu082, PubMed 24511080
Pettersen EO, Ebbesen P, Gieling RG, Williams KJ, Dubois L, Lambin P, Ward C, Meehan J, Kunkler IH, Langdon SP, Ree AH, Flatmark K, Lyng H, Calzada MJ, Peso LD, Landazuri MO, Görlach A, Flamm H, Kieninger J, Urban G, Weltin A, Singleton DC, Haider S, Buffa FM, Harris AL et al. (2014)
Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium
J Enzyme Inhib Med Chem, 30 (5), 689-721
DOI 10.3109/14756366.2014.966704, PubMed 25347767
Ree AH, Meltzer S, Flatmark K, Dueland S, Kalanxhi E (2014)
Biomarkers of treatment toxicity in combined-modality cancer therapies with radiation and systemic drugs: study design, multiplex methods, molecular networks
Int J Mol Sci, 15 (12), 22835-56
DOI 10.3390/ijms151222835, PubMed 25501337
Ree AH, Saelen MG, Kalanxhi E, Østensen IH, Schee K, Røe K, Abrahamsen TW, Dueland S, Flatmark K (2014)
Biomarkers of histone deacetylase inhibitor activity in a phase 1 combined-modality study with radiotherapy
PLoS One, 9 (2), e89750
DOI 10.1371/journal.pone.0089750, PubMed 24587009
Skrbo N, Hjortland GO, Kristian A, Holm R, Nord S, Prasmickaite L, Engebraaten O, Mælandsmo GM, Sørlie T, Andersen K (2014)
Differential in vivo tumorigenicity of distinct subpopulations from a luminal-like breast cancer xenograft
PLoS One, 9 (11), e113278
DOI 10.1371/journal.pone.0113278, PubMed 25419568
Skårn M, Noordhuis P, Wang MY, Veuger M, Kresse SH, Egeland EV, Micci F, Namløs HM, Håkelien AM, Olafsrud SM, Lorenz S, Haraldsen G, Kvalheim G, Meza-Zepeda LA, Myklebost O (2014)
Generation and characterization of an immortalized human mesenchymal stromal cell line
Stem Cells Dev, 23 (19), 2377-89
DOI 10.1089/scd.2013.0599, PubMed 24857590
Tubio JMC, Li Y, Ju YS, Martincorena I, Cooke SL, Tojo M, Gundem G, Pipinikas CP, Zamora J, Raine K, Menzies A, Roman-Garcia P, Fullam A, Gerstung M, Shlien A, Tarpey PS, Papaemmanuil E, Knappskog S, Van Loo P, Ramakrishna M, Davies HR, Marshall J, Wedge DC, Teague JW, Butler AP et al. (2014)
Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes
Science, 345 (6196), 1251343
DOI 10.1126/science.1251343, PubMed 25082706
Wennerström AB, Lothe IM, Sandhu V, Kure EH, Myklebost O, Munthe E (2014)
Generation and characterisation of novel pancreatic adenocarcinoma xenograft models and corresponding primary cell lines
PLoS One, 9 (8), e103873
DOI 10.1371/journal.pone.0103873, PubMed 25148029
Wiiger MT, Bideli H, Fodstad O, Flatmark K, Andersson Y (2014)
The MOC31PE immunotoxin reduces cell migration and induces gene expression and cell death in ovarian cancer cells
J Ovarian Res, 7, 23
DOI 10.1186/1757-2215-7-23, PubMed 24528603

Publications 2013

Behjati S, Tarpey PS, Presneau N, Scheipl S, Pillay N, Van Loo P, Wedge DC, Cooke SL, Gundem G, Davies H, Nik-Zainal S, Martin S, McLaren S, Goodie V, Robinson B, Butler A, Teague JW, Halai D, Khatri B, Myklebost O, Baumhoer D, Jundt G, Hamoudi R, Tirabosco R, Amary MF et al. (2013)
Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone
Nat Genet, 45 (12), 1479-82
DOI 10.1038/ng.2814, PubMed 24162739
Bettum IJ, Vasiliauskaite K, Nygaard V, Clancy T, Pettersen SJ, Tenstad E, Mælandsmo GM, Prasmickaite L (2013)
Metastasis-associated protein S100A4 induces a network of inflammatory cytokines that activate stromal cells to acquire pro-tumorigenic properties
Cancer Lett, 344 (1), 28-39
DOI 10.1016/j.canlet.2013.10.036, PubMed 24215866
Bianchini L, Birtwisle L, Saâda E, Bazin A, Long E, Roussel JF, Michiels JF, Forest F, Dani C, Myklebost O, Birtwisle-Peyrottes I, Pedeutour F (2013)
Identification of PPAP2B as a novel recurrent translocation partner gene of HMGA2 in lipomas
Genes Chromosomes Cancer, 52 (6), 580-90
DOI 10.1002/gcc.22055, PubMed 23508853
Bruheim S, Sandvold ML, Mælandsmo GM, Fodstad O (2013)
Antitumor activity of elacytarabine combined with bevacizumab, cetuximab and trastuzumab in human NSCLC xenografts
Anticancer Res, 33 (9), 3615-21
PubMed 24023287
Bøe SL, Hovig E (2013)
Enhancing nucleic acid delivery by photochemical internalization
Ther Deliv, 4 (9), 1125-40
DOI 10.4155/tde.13.78, PubMed 24024512
Bøe SL, Hovig E (2013)
Light-induced mRNA transfection
Methods Mol Biol, 969, 89-100
DOI 10.1007/978-1-62703-260-5_6, PubMed 23296929
Bøe SL, Jørgensen JA, Longva AS, Lavelle T, Sæbøe-Larssen S, Hovig E (2013)
Light-controlled modulation of gene expression using polyamidoamine formulations
Nucleic Acid Ther, 23 (2), 160-5
DOI 10.1089/nat.2012.0413, PubMed 23530684
Clancy T, Rødland EA, Nygard S, Hovig E (2013)
Predicting physical interactions between protein complexes
Mol Cell Proteomics, 12 (6), 1723-34
DOI 10.1074/mcp.O112.019828, PubMed 23438732
Desai S, Liu Z, Yao J, Patel N, Chen J, Wu Y, Ahn EE, Fodstad O, Tan M (2013)
Heat shock factor 1 (HSF1) controls chemoresistance and autophagy through transcriptional regulation of autophagy-related protein 7 (ATG7)
J Biol Chem, 288 (13), 9165-76
DOI 10.1074/jbc.M112.422071, PubMed 23386620
Doorn J, Fernandes HA, Le BQ, van de Peppel J, van Leeuwen JP, De Vries MR, Aref Z, Quax PH, Myklebost O, Saris DB, van Blitterswijk CA, de Boer J (2013)
A small molecule approach to engineering vascularized tissue
Biomaterials, 34 (12), 3053-63
DOI 10.1016/j.biomaterials.2012.12.037, PubMed 23369216
Eide T, Ramberg H, Glackin C, Tindall D, Taskén KA (2013)
TWIST1, A novel androgen-regulated gene, is a target for NKX3-1 in prostate cancer cells
Cancer Cell Int, 13 (1), 4
DOI 10.1186/1475-2867-13-4, PubMed 23368843
Engebraaten O, Vollan HKM, Børresen-Dale AL (2013)
Triple-negative breast cancer and the need for new therapeutic targets
Am J Pathol, 183 (4), 1064-1074
DOI 10.1016/j.ajpath.2013.05.033, PubMed 23920327
Esmaeili M, Bathen TF, Engebråten O, Mælandsmo GM, Gribbestad IS, Moestue SA (2013)
Quantitative (31)P HR-MAS MR spectroscopy for detection of response to PI3K/mTOR inhibition in breast cancer xenografts
Magn Reson Med, 71 (6), 1973-81
DOI 10.1002/mrm.24869, PubMed 23878023
Flatmark K, Guldvik IJ, Svensson H, Fleten KG, Flørenes VA, Reed W, Giercksky KE, Fodstad Ø, Andersson Y (2013)
Immunotoxin targeting EpCAM effectively inhibits peritoneal tumor growth in experimental models of mucinous peritoneal surface malignancies
Int J Cancer, 133 (6), 1497-506
DOI 10.1002/ijc.28158, PubMed 23494569
Friedman R, Boye K, Flatmark K (2013)
Molecular modelling and simulations in cancer research
Biochim Biophys Acta, 1836 (1), 1-14
DOI 10.1016/j.bbcan.2013.02.001, PubMed 23416097
Fromm B, Worren MM, Hahn C, Hovig E, Bachmann L (2013)
Substantial loss of conserved and gain of novel MicroRNA families in flatworms
Mol Biol Evol, 30 (12), 2619-28
DOI 10.1093/molbev/mst155, PubMed 24025793
Grytli HH, Fagerland MW, Fosså SD, Taskén KA (2013)
Association between use of β-blockers and prostate cancer-specific survival: a cohort study of 3561 prostate cancer patients with high-risk or metastatic disease
Eur Urol, 65 (3), 635-41
DOI 10.1016/j.eururo.2013.01.007, PubMed 23351721
Grytli HH, Fagerland MW, Fosså SD, Taskén KA (2013)
Reply to Chris R. Cardwell, Samy Suissa and Liam J. Murray's letter to the editor re: Helene Hartvedt Grytli, Morten Wang Fagerland, Sophie D. Fosså, Kristin Austlid Taskén. Association between use of β-blockers and prostate cancer-specific survival: a cohort study of 3561 prostate cancer patients with high-risk or metastatic disease. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2013.01.007
Eur Urol, 64 (1), e11-2
DOI 10.1016/j.eururo.2013.03.045, PubMed 23602404
Haugen MH, Johansen HT, Pettersen SJ, Solberg R, Brix K, Flatmark K, Maelandsmo GM (2013)
Nuclear legumain activity in colorectal cancer
PLoS One, 8 (1), e52980
DOI 10.1371/journal.pone.0052980, PubMed 23326369
Haugsten EM, Oppelt A, Wesche J (2013)
Phosphatidylinositol 5-phosphate is a second messenger important for cell migration
Commun Integr Biol, 6 (5), e25446
DOI 10.4161/cib.25446, PubMed 24265857
Herlofsen SR, Bryne JC, Høiby T, Wang L, Issner R, Zhang X, Coyne MJ, Boyle P, Gu H, Meza-Zepeda LA, Collas P, Mikkelsen TS, Brinchmann JE (2013)
Genome-wide map of quantified epigenetic changes during in vitro chondrogenic differentiation of primary human mesenchymal stem cells
BMC Genomics, 14, 105
DOI 10.1186/1471-2164-14-105, PubMed 23414147
Hongisto V, Jernström S, Fey V, Mpindi JP, Kleivi Sahlberg K, Kallioniemi O, Perälä M (2013)
High-throughput 3D screening reveals differences in drug sensitivities between culture models of JIMT1 breast cancer cells
PLoS One, 8 (10), e77232
DOI 10.1371/journal.pone.0077232, PubMed 24194875
Itkonen HM, Minner S, Guldvik IJ, Sandmann MJ, Tsourlakis MC, Berge V, Svindland A, Schlomm T, Mills IG (2013)
O-GlcNAc transferase integrates metabolic pathways to regulate the stability of c-MYC in human prostate cancer cells
Cancer Res, 73 (16), 5277-87
DOI 10.1158/0008-5472.CAN-13-0549, PubMed 23720054
Jin Y, Qu S, Tesikova M, Wang L, Kristian A, Mælandsmo GM, Kong H, Zhang T, Jerónimo C, Teixeira MR, Yuca E, Tekedereli I, Gorgulu K, Alpay N, Sood AK, Lopez-Berestein G, Danielsen HE, Ozpolat B, Saatcioglu F (2013)
Molecular circuit involving KLK4 integrates androgen and mTOR signaling in prostate cancer
Proc Natl Acad Sci U S A, 110 (28), E2572-81
DOI 10.1073/pnas.1304318110, PubMed 23798432
Jørgensen JA, Longva AS, Hovig E, Bøe SL (2013)
Evaluation of biodegradable peptide carriers for light-directed targeting
Nucleic Acid Ther, 23 (2), 131-9
DOI 10.1089/nat.2012.0403, PubMed 23405950
Kongsgaard A, Borgen E, Mælandsmo GM, Flatmark K, Le H, Josefsen D, Solvoll I, Schirmer CB, Helland Å, Jørgensen L, Brustugun OT, Fodstad Ø, Boye K (2013)
Clinical significance of disseminated tumour cells in non-small cell lung cancer
Br J Cancer, 109 (5), 1264-70
DOI 10.1038/bjc.2013.450, PubMed 23942067
Kongsgaard A, Boye K, Oijordsbakken M, Lund-Iversen M, Halvorsen AR, Solberg SK, Berge G, Helland A, Brustugun OT, Mælandsmo GM (2013)
Osteopontin is a prognostic biomarker in non-small cell lung cancer
BMC Cancer, 13, 540
DOI 10.1186/1471-2407-13-540, PubMed 24215488
Kristian A, Nilsen LB, Røe K, Revheim ME, Engebråten O, Mælandsmo GM, Holm R, Malinen E, Seierstad T (2013)
Dynamic (18) F-FDG PET for Assessment of Tumor Physiology in Two Breast Carcinoma Xenografts
Nucl Med Mol Imaging, 47 (3), 173-80
DOI 10.1007/s13139-013-0211-y, PubMed 24900104
Kristian A, Revheim ME, Qu H, Mælandsmo GM, Engebråten O, Seierstad T, Malinen E (2013)
Dynamic (18)F-FDG-PET for monitoring treatment effect following anti-angiogenic therapy in triple-negative breast cancer xenografts
Acta Oncol, 52 (7), 1566-72
DOI 10.3109/0284186X.2013.813634, PubMed 23984812
Kuijjer ML, Peterse EF, van den Akker BE, Briaire-de Bruijn IH, Serra M, Meza-Zepeda LA, Myklebost O, Hassan AB, Hogendoorn PC, Cleton-Jansen AM (2013)
IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma
BMC Cancer, 13, 245
DOI 10.1186/1471-2407-13-245, PubMed 23688189
Lando M, Wilting SM, Snipstad K, Clancy T, Bierkens M, Aarnes EK, Holden M, Stokke T, Sundfør K, Holm R, Kristensen GB, Steenbergen RD, Lyng H (2013)
Identification of eight candidate target genes of the recurrent 3p12-p14 loss in cervical cancer by integrative genomic profiling
J Pathol, 230 (1), 59-69
DOI 10.1002/path.4168, PubMed 23335387
Lauvrak SU, Munthe E, Kresse SH, Stratford EW, Namløs HM, Meza-Zepeda LA, Myklebost O (2013)
Functional characterisation of osteosarcoma cell lines and identification of mRNAs and miRNAs associated with aggressive cancer phenotypes
Br J Cancer, 109 (8), 2228-36
DOI 10.1038/bjc.2013.549, PubMed 24064976
Lindholm EM, Krohn M, Iadevaia S, Kristian A, Mills GB, Mælandsmo GM, Engebraaten O (2013)
Proteomic characterization of breast cancer xenografts identifies early and late bevacizumab-induced responses and predicts effective drug combinations
Clin Cancer Res, 20 (2), 404-12
DOI 10.1158/1078-0432.CCR-13-1865, PubMed 24192926
Lorvik KB, Haabeth OA, Clancy T, Bogen B, Corthay A (2013)
Molecular profiling of tumor-specific T_H1 cells activated in vivo
Oncoimmunology, 2 (5), e24383
DOI 10.4161/onci.24383, PubMed 23762808
Moestue SA, Dam CG, Gorad SS, Kristian A, Bofin A, Mælandsmo GM, Engebråten O, Gribbestad IS, Bjørkøy G (2013)
Metabolic biomarkers for response to PI3K inhibition in basal-like breast cancer
Breast Cancer Res, 15 (1), R16
DOI 10.1186/bcr3391, PubMed 23448424
Moestue SA, Huuse EM, Lindholm EM, Bofin A, Engebraaten O, Mælandsmo GM, Akslen LA, Gribbestad IS (2013)
Low-molecular contrast agent dynamic contrast-enhanced (DCE)-MRI and diffusion-weighted (DW)-MRI in early assessment of bevacizumab treatment in breast cancer xenografts
J Magn Reson Imaging, 38 (5), 1043-53
DOI 10.1002/jmri.24079, PubMed 23908122
Nome T, Thomassen GO, Bruun J, Ahlquist T, Bakken AC, Hoff AM, Rognum T, Nesbakken A, Lorenz S, Sun J, Barros-Silva JD, Lind GE, Myklebost O, Teixeira MR, Meza-Zepeda LA, Lothe RA, Skotheim RI (2013)
Common fusion transcripts identified in colorectal cancer cell lines by high-throughput RNA sequencing
Transl Oncol, 6 (5), 546-53
DOI 10.1593/tlo.13457, PubMed 24151535
Paulsen J, Lien TG, Sandve GK, Holden L, Borgan O, Glad IK, Hovig E (2013)
Handling realistic assumptions in hypothesis testing of 3D co-localization of genomic elements
Nucleic Acids Res, 41 (10), 5164-74
DOI 10.1093/nar/gkt227, PubMed 23571755
Qu S, Olafsrud SM, Meza-Zepeda LA, Saatcioglu F (2013)
Rapid gene expression changes in peripheral blood lymphocytes upon practice of a comprehensive yoga program
PLoS One, 8 (4), e61910
DOI 10.1371/journal.pone.0061910, PubMed 23613970
Ragnum HB, Røe K, Holm R, Vlatkovic L, Nesland JM, Aarnes EK, Ree AH, Flatmark K, Seierstad T, Lilleby W, Lyng H (2013)
Hypoxia-independent downregulation of hypoxia-inducible factor 1 targets by androgen deprivation therapy in prostate cancer
Int J Radiat Oncol Biol Phys, 87 (4), 753-60
DOI 10.1016/j.ijrobp.2013.07.023, PubMed 24035332
Revheim ME, Kristian A, Malinen E, Bruland ØS, Berner JM, Holm R, Joensuu H, Seierstad T (2013)
Intermittent and continuous imatinib in a human GIST xenograft model carrying KIT exon 17 resistance mutation D816H
Acta Oncol, 52 (4), 776-82
DOI 10.3109/0284186X.2013.770920, PubMed 23480638
Rødland EA (2013)
Compact representation of k-mer de Bruijn graphs for genome read assembly
BMC Bioinformatics, 14, 313
DOI 10.1186/1471-2105-14-313, PubMed 24152242
Røe K, Bratland Å, Vlatkovic L, Ragnum HB, Saelen MG, Olsen DR, Marignol L, Ree AH (2013)
Hypoxic tumor kinase signaling mediated by STAT5A in development of castration-resistant prostate cancer
PLoS One, 8 (5), e63723
DOI 10.1371/journal.pone.0063723, PubMed 23675504
Sandberg CJ, Altschuler G, Jeong J, Strømme KK, Stangeland B, Murrell W, Grasmo-Wendler UH, Myklebost O, Helseth E, Vik-Mo EO, Hide W, Langmoen IA (2013)
Comparison of glioma stem cells to neural stem cells from the adult human brain identifies dysregulated Wnt- signaling and a fingerprint associated with clinical outcome
Exp Cell Res, 319 (14), 2230-43
DOI 10.1016/j.yexcr.2013.06.004, PubMed 23791939
Sandve GK, Gundersen S, Johansen M, Glad IK, Gunathasan K, Holden L, Holden M, Liestøl K, Nygård S, Nygaard V, Paulsen J, Rydbeck H, Trengereid K, Clancy T, Drabløs F, Ferkingstad E, Kalas M, Lien T, Rye MB, Frigessi A, Hovig E (2013)
The Genomic HyperBrowser: an analysis web server for genome-scale data
Nucleic Acids Res, 41 (Web Server issue), W133-41
DOI 10.1093/nar/gkt342, PubMed 23632163
Sandve GK, Nekrutenko A, Taylor J, Hovig E (2013)
Ten simple rules for reproducible computational research
PLoS Comput Biol, 9 (10), e1003285
DOI 10.1371/journal.pcbi.1003285, PubMed 24204232
Schee K, Lorenz S, Worren MM, Günther CC, Holden M, Hovig E, Fodstad O, Meza-Zepeda LA, Flatmark K (2013)
Deep Sequencing the MicroRNA Transcriptome in Colorectal Cancer
PLoS One, 8 (6), e66165
DOI 10.1371/journal.pone.0066165, PubMed 23824282
Skårn M, Barøy T, Stratford EW, Myklebost O (2013)
Epigenetic regulation and functional characterization of microRNA-142 in mesenchymal cells
PLoS One, 8 (11), e79231
DOI 10.1371/journal.pone.0079231, PubMed 24236112
Stratford EW, Bostad M, Castro R, Skarpen E, Berg K, Høgset A, Myklebost O, Selbo PK (2013)
Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity
Biochim Biophys Acta, 1830 (8), 4235-43
DOI 10.1016/j.bbagen.2013.04.033, PubMed 23643966
Stratford EW, Daffinrud J, Munthe E, Castro R, Waaler J, Krauss S, Myklebost O (2013)
The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines
Cancer Med, 3 (1), 36-46
DOI 10.1002/cam4.170, PubMed 24403055
Sørensen O, Andersen AM, Kristian A, Giercksky KE, Flatmark K (2013)
Impact of hyperthermia on pharmacokinetics of intraperitoneal mitomycin C in rats investigated by microdialysis
J Surg Oncol, 109 (6), 521-6
DOI 10.1002/jso.23527, PubMed 24347444
Tahiri A, Leivonen SK, Lüders T, Steinfeld I, Ragle Aure M, Geisler J, Mäkelä R, Nord S, Riis ML, Yakhini Z, Kleivi Sahlberg K, Børresen-Dale AL, Perälä M, Bukholm IR, Kristensen VN (2013)
Deregulation of cancer-related miRNAs is a common event in both benign and malignant human breast tumors
Carcinogenesis, 35 (1), 76-85
DOI 10.1093/carcin/bgt333, PubMed 24104550
Wang P, Gao Q, Suo Z, Munthe E, Solberg S, Ma L, Wang M, Westerdaal NA, Kvalheim G, Gaudernack G (2013)
Identification and characterization of cells with cancer stem cell properties in human primary lung cancer cell lines
PLoS One, 8 (3), e57020 (Retracted)
DOI 10.1371/journal.pone.0057020, PubMed 23469181
Wang P, Suo Z, Wang M, Høifødt HK, Fodstad O, Gaudernack G, Kvalheim G (2013)
In vitro and in vivo properties of CD133 expressing cells from human lung cancer cell lines
Exp Hematol Oncol, 2 (1), 16
DOI 10.1186/2162-3619-2-16, PubMed 23738757
Yri OE, Ekstrøm PO, Hilden V, Gaudernack G, Liestøl K, Smeland EB, Holte H (2013)
Influence of polymorphisms in genes encoding immunoregulatory proteins and metabolizing enzymes on susceptibility and outcome in patients with diffuse large B-cell lymphoma treated with rituximab
Leuk Lymphoma, 54 (10), 2205-14
DOI 10.3109/10428194.2013.774392, PubMed 23391141
Zhai H, Fesler A, Schee K, Fodstad O, Flatmark K, Ju J (2013)
Clinical significance of long intergenic noncoding RNA-p21 in colorectal cancer
Clin Colorectal Cancer, 12 (4), 261-6
DOI 10.1016/j.clcc.2013.06.003, PubMed 24012455

Publications 2012

Bjørnstad LG, Meza TJ, Otterlei M, Olafsrud SM, Meza-Zepeda LA, Falnes PØ (2012)
Human ALKBH4 interacts with proteins associated with transcription
PLoS One, 7 (11), e49045
DOI 10.1371/journal.pone.0049045, PubMed 23145062
Borgan E, Lindholm EM, Moestue S, Mælandsmo GM, Lingjærde OC, Gribbestad IS, Børresen-Dale AL, Engebraaten O, Sørlie T (2012)
Subtype-specific response to bevacizumab is reflected in the metabolome and transcriptome of breast cancer xenografts
Mol Oncol, 7 (1), 130-42
DOI 10.1016/j.molonc.2012.10.005, PubMed 23142657
Boye K, Nesland JM, Sandstad B, Haugland Haugen M, Mælandsmo GM, Flatmark K (2012)
EMMPRIN is associated with S100A4 and predicts patient outcome in colorectal cancer
Br J Cancer, 107 (4), 667-74
DOI 10.1038/bjc.2012.293, PubMed 22782346
Brusegard K, Stavnes HT, Nymoen DA, Flatmark K, Trope CG, Davidson B (2012)
Rab25 is overexpressed in Müllerian serous carcinoma compared to malignant mesothelioma
Virchows Arch, 460 (2), 193-202
DOI 10.1007/s00428-011-1191-x, PubMed 22249560
Cejudo-Marín R, Tárrega C, Nunes-Xavier CE, Pulido R (2012)
Caspase-3 cleavage of DUSP6/MKP3 at the interdomain region generates active MKP3 fragments that regulate ERK1/2 subcellular localization and function
J Mol Biol, 420 (1-2), 128-38
DOI 10.1016/j.jmb.2012.04.004, PubMed 22504224
Chymkowitch P, Eldholm V, Lorenz S, Zimmermann C, Lindvall JM, Bjørås M, Meza-Zepeda LA, Enserink JM (2012)
Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes
Proc Natl Acad Sci U S A, 109 (26), 10450-5
DOI 10.1073/pnas.1200067109, PubMed 22689984
Ding Y, Liu Z, Desai S, Zhao Y, Liu H, Pannell LK, Yi H, Wright ER, Owen LB, Dean-Colomb W, Fodstad O, Lu J, LeDoux SP, Wilson GL, Tan M (2012)
Receptor tyrosine kinase ErbB2 translocates into mitochondria and regulates cellular metabolism
Nat Commun, 3, 1271
DOI 10.1038/ncomms2236, PubMed 23232401
Eide N, Hoifødt HK, Nesland JM, Faye RS, Qvale GA, Faber RT, Jebsen P, Kvalheim G, Fodstad Ø (2012)
Disseminated tumour cells in bone marrow of patients with uveal melanoma
Acta Ophthalmol, 91 (4), 343-8
DOI 10.1111/j.1755-3768.2012.02449.x, PubMed 22632270
Ekstrøm PO, Warren DJ, Thilly WG (2012)
Separation principles of cycling temperature capillary electrophoresis
Electrophoresis, 33 (7), 1162-8
DOI 10.1002/elps.201100550, PubMed 22539319
Engesæter B, Engebraaten O, Flørenes VA, Mælandsmo GM (2012)
Dacarbazine and the agonistic TRAIL receptor-2 antibody lexatumumab induce synergistic anticancer effects in melanoma
PLoS One, 7 (9), e45492
DOI 10.1371/journal.pone.0045492, PubMed 23029050
Grytli HH, Fagerland MW, Fosså SD, Taskén KA, Håheim LL (2012)
Use of β-blockers is associated with prostate cancer-specific survival in prostate cancer patients on androgen deprivation therapy
Prostate, 73 (3), 250-60
DOI 10.1002/pros.22564, PubMed 22821802
Ingebrigtsen VA, Boye K, Tekle C, Nesland JM, Flatmark K, Fodstad O (2012)
B7-H3 expression in colorectal cancer: nuclear localization strongly predicts poor outcome in colon cancer
Int J Cancer, 131 (11), 2528-36
DOI 10.1002/ijc.27566, PubMed 22473715
Jørgensen JA, Hovig E, Bøe SL (2012)
Potent gene silencing in vitro at physiological pH using chitosan polymers
Nucleic Acid Ther, 22 (2), 96-102
DOI 10.1089/nat.2011.0335, PubMed 22480314
Kernstock S, Davydova E, Jakobsson M, Moen A, Pettersen S, Mælandsmo GM, Egge-Jacobsen W, Falnes PØ (2012)
Lysine methylation of VCP by a member of a novel human protein methyltransferase family
Nat Commun, 3, 1038
DOI 10.1038/ncomms2041, PubMed 22948820
Kongsgaard A, Lund-Iversen M, Berge G, Brustugun OT, Solberg SK, Mælandsmo GM, Boye K (2012)
Expression of S100A4, ephrin-A1 and osteopontin in non-small cell lung cancer
BMC Cancer, 12, 333
DOI 10.1186/1471-2407-12-333, PubMed 22853000
Kresse SH, Rydbeck H, Skårn M, Namløs HM, Barragan-Polania AH, Cleton-Jansen AM, Serra M, Liestøl K, Hogendoorn PC, Hovig E, Myklebost O, Meza-Zepeda LA (2012)
Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma
PLoS One, 7 (11), e48262
DOI 10.1371/journal.pone.0048262, PubMed 23144859
Kuijjer ML, Rydbeck H, Kresse SH, Buddingh EP, Lid AB, Roelofs H, Bürger H, Myklebost O, Hogendoorn PC, Meza-Zepeda LA, Cleton-Jansen AM (2012)
Identification of osteosarcoma driver genes by integrative analysis of copy number and gene expression data
Genes Chromosomes Cancer, 51 (7), 696-706
DOI 10.1002/gcc.21956, PubMed 22454324
Lindholm EM, Kristian A, Nalwoga H, Krüger K, Nygård S, Akslen LA, Mælandsmo GM, Engebraaten O (2012)
Effect of antiangiogenic therapy on tumor growth, vasculature and kinase activity in basal- and luminal-like breast cancer xenografts
Mol Oncol, 6 (4), 418-27
DOI 10.1016/j.molonc.2012.03.006, PubMed 22521242
Liu F, Kuo WP, Jenssen TK, Hovig E (2012)
Performance comparison of multiple microarray platforms for gene expression profiling
Methods Mol Biol, 802, 141-55
DOI 10.1007/978-1-61779-400-1_10, PubMed 22130879
Liu Z, Liu H, Desai S, Schmitt DC, Zhou M, Khong HT, Klos KS, McClellan S, Fodstad O, Tan M (2012)
miR-125b functions as a key mediator for snail-induced stem cell propagation and chemoresistance
J Biol Chem, 288 (6), 4334-45
DOI 10.1074/jbc.M112.419168, PubMed 23255607
Magnussen GI, Ree Rosnes AK, Shahzidi S, Dong HP, Emilsen E, Engesæter B, Flørenes VA (2012)
Synthetic retinoid CD437 induces apoptosis and acts synergistically with TRAIL receptor-2 agonist in malignant melanoma
Biochem Biophys Res Commun, 420 (3), 516-22
DOI 10.1016/j.bbrc.2012.03.023, PubMed 22446330
Mattingsdal M, Brown AA, Djurovic S, Sønderby IE, Server A, Melle I, Agartz I, Hovig E, Jensen J, Andreassen OA (2012)
Pathway analysis of genetic markers associated with a functional MRI faces paradigm implicates polymorphisms in calcium responsive pathways
Neuroimage, 70, 143-9
DOI 10.1016/j.neuroimage.2012.12.035, PubMed 23274185
Nakken S, Johansen M, Fillebeen J, Berge OP, Kirkerød H, Jenssen TK, Hovig E (2012)
CellLineMiner: a knowledge portal for human cell lines
Bioinformation, 8 (22), 1119-22
DOI 10.6026/97320630081119, PubMed 23251048
Namløs HM, Kresse SH, Müller CR, Henriksen J, Holdhus R, Sæter G, Bruland OS, Bjerkehagen B, Steen VM, Myklebost O (2012)
Global gene expression profiling of human osteosarcomas reveals metastasis-associated chemokine pattern
Sarcoma, 2012, 639038
DOI 10.1155/2012/639038, PubMed 22518090
Namløs HM, Meza-Zepeda LA, Barøy T, Østensen IH, Kresse SH, Kuijjer ML, Serra M, Bürger H, Cleton-Jansen AM, Myklebost O (2012)
Modulation of the osteosarcoma expression phenotype by microRNAs
PLoS One, 7 (10), e48086
DOI 10.1371/journal.pone.0048086, PubMed 23133552
Ohnstad HO, Castro R, Sun J, Heintz KM, Vassilev LT, Bjerkehagen B, Kresse SH, Meza-Zepeda LA, Myklebost O (2012)
Correlation of TP53 and MDM2 genotypes with response to therapy in sarcoma
Cancer, 119 (5), 1013-22
DOI 10.1002/cncr.27837, PubMed 23165797
Ree AH (2012)
Individualised treatment of metastatic cancer
Tidsskr Nor Laegeforen, 132 (21), 2358-9
DOI 10.4045/tidsskr.12.1130, PubMed 23160572
Ree AH, Kristensen AT, Saelen MG, de Wijn R, Edvardsen H, Jovanovic J, Abrahamsen TW, Dueland S, Flatmark K (2012)
Tumor phosphatidylinositol-3-kinase signaling and development of metastatic disease in locally advanced rectal cancer
PLoS One, 7 (11), e50806
DOI 10.1371/journal.pone.0050806, PubMed 23226389
Reikvam DH, Derrien M, Islam R, Erofeev A, Grcic V, Sandvik A, Gaustad P, Meza-Zepeda LA, Jahnsen FL, Smidt H, Johansen FE (2012)
Epithelial-microbial crosstalk in polymeric Ig receptor deficient mice
Eur J Immunol, 42 (11), 2959-70
DOI 10.1002/eji.201242543, PubMed 22865203
Saelen MG, Ree AH, Kristian A, Fleten KG, Furre T, Hektoen HH, Flatmark K (2012)
Radiosensitization by the histone deacetylase inhibitor vorinostat under hypoxia and with capecitabine in experimental colorectal carcinoma
Radiat Oncol, 7, 165
DOI 10.1186/1748-717X-7-165, PubMed 23017053
Schee K, Boye K, Abrahamsen TW, Fodstad Ø, Flatmark K (2012)
Clinical relevance of microRNA miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145 in colorectal cancer
BMC Cancer, 12, 505
DOI 10.1186/1471-2407-12-505, PubMed 23121918
Schee K, Flatmark K, Holm R, Boye K, Paus E (2012)
Investigation of nonspecific cross-reacting antigen 2 as a prognostic biomarker in bone marrow plasma from colorectal cancer patients (vol 33, pg 73, 2012)
Tumor Biol., 33 (4), 1263-1264
DOI 10.1007/s13277-012-0407-2