Nils Bolstad
- Group leader, Consultant; PhD
- +47 22 93 59 05
Publications 2024
Monoclonal Insulin Autoimmune Syndrome Successfully Treated With Plasma Cell Directed Therapy
Clin Lymphoma Myeloma Leuk (in press)
DOI 10.1016/j.clml.2024.10.005, PubMed 39500643
Clinical consequences of infliximab immunogenicity and the effect of proactive therapeutic drug monitoring: exploratory analyses of the randomised, controlled NOR-DRUM trials
Lancet Rheumatol, 6 (4), e226-e236
DOI 10.1016/S2665-9913(23)00341-7, PubMed 38402891
Therapeutic serum level for adalimumab in rheumatoid arthritis: explorative analyses of data from a randomised phase III trial
RMD Open, 10 (4)
DOI 10.1136/rmdopen-2024-004888, PubMed 39537558
Efficacy of a TNF inhibitor in chronic low back pain with Modic changes type 1: The BackToBasic study A randomized controlled trial
Arthritis Rheumatol (in press)
DOI 10.1002/art.43073, PubMed 39624017
Adalimumab serum levels and anti-drug antibodies: associations to treatment response and drug survival in inflammatory joint diseases
Rheumatology (Oxford), 63 (6), 1746-1755
DOI 10.1093/rheumatology/kead525, PubMed 37773994
Coeliac disease in the Trøndelag Health Study (HUNT), Norway, a population-based cohort of coeliac disease patients
BMJ Open, 14 (1), e077131
DOI 10.1136/bmjopen-2023-077131, PubMed 38195172
The Prevalence and Rate of Undiagnosed Celiac Disease in an Adult General Population, the Trøndelag Health Study, Norway
Clin Gastroenterol Hepatol (in press)
DOI 10.1016/j.cgh.2024.06.027, PubMed 38987013
Managing hemolysis in serum neuron-specific enolase measurements - an automated algorithm for routine practice
Scand J Clin Lab Invest, 84 (4), 225-229
DOI 10.1080/00365513.2024.2359091, PubMed 38853575
Effects of prednisolone tapering on effectiveness of infliximab in patients with ulcerative colitis: data from a retrospective cohort
BMJ Open Gastroenterol, 11 (1)
DOI 10.1136/bmjgast-2024-001343, PubMed 38719549
Performance of Faecal Immunochemical Testing for Colorectal Cancer Screening at Varying Positivity Thresholds
Aliment Pharmacol Ther, 61 (1), 122-131
DOI 10.1111/apt.18314, PubMed 39373173
Therapeutic Drug Monitoring: A Tool to Optimize Treatment of Inflammatory Joint Diseases
Arthritis Rheumatol, 76 (5), 667-669
DOI 10.1002/art.42764, PubMed 37984460
Subcutaneous Vedolizumab Treatment in a Real-World Inflammatory Bowel Disease Cohort Switched From Intravenous Vedolizumab: Eighteen-Month Prospective Follow-up Study
Crohns Colitis 360, 6 (1), otae013
DOI 10.1093/crocol/otae013, PubMed 38544907
Publications 2023
Transplacental passage of belimumab during pregnancy and follow-up of a child exposed in utero
Ann Rheum Dis, 82 (4), 577-579
DOI 10.1136/ard-2022-223684, PubMed 36604152
HLA-DQ2 is associated with anti-drug antibody formation to infliximab in patients with immune-mediated inflammatory diseases
J Intern Med, 293 (5), 648-655
DOI 10.1111/joim.13616, PubMed 36843323
Humoral immune response to SARS-CoV-2 vaccination in patients with inflammatory bowel disease on immunosuppressive medication: association to serum drug levels and disease type
Scand J Gastroenterol, 58 (8), 874-882
DOI 10.1080/00365521.2023.2177884, PubMed 36788656
Insulin autoimmune syndrome: not just one but two different diseases with therapeutic implications
Endocrinol Diabetes Metab Case Rep, 2023 (4)
DOI 10.1530/EDM-23-0032, PubMed 37988766
Switching from intravenous to subcutaneous vedolizumab maintenance treatment in patients with inflammatory bowel disease followed by therapeutic drug monitoring
Scand J Gastroenterol, 58 (8), 863-873
DOI 10.1080/00365521.2023.2176252, PubMed 36799155
Publications 2022
Risk factors for anti-drug antibody formation to infliximab: Secondary analyses of a randomised controlled trial
J Intern Med, 292 (3), 477-491
DOI 10.1111/joim.13495, PubMed 35411981
Drug Levels Associated With Optimal Discrimination Between Remission and Nonremission and Comparison of Antibody Assays During First Year of Stable Infliximab Maintenance Therapy in Inflammatory Bowel Disease
Ther Drug Monit, 44 (2), 290-300
DOI 10.1097/FTD.0000000000000913, PubMed 34387220
Assessing Immunogenicity of Biologic Drugs in Inflammatory Joint Diseases: Progress Towards Personalized Medicine
BioDrugs, 36 (6), 731-748
DOI 10.1007/s40259-022-00559-1, PubMed 36315391
The development and validation of a high-capacity serological assay for celiac disease
Clin Biochem, 107, 13-18
DOI 10.1016/j.clinbiochem.2022.05.010, PubMed 35660483
Publications 2021
Rheumatoid factor and falsely elevated results in commercial immunoassays: data from an early arthritis cohort
Rheumatol Int, 41 (9), 1657-1665
DOI 10.1007/s00296-021-04865-9, PubMed 33944985
Serum etanercept concentrations in relation to disease activity and treatment response assessed by ultrasound, biomarkers and clinical disease activity scores: results from a prospective observational study of patients with rheumatoid arthritis
RMD Open, 7 (3)
DOI 10.1136/rmdopen-2021-001985, PubMed 34911811
Serum golimumab concentration and anti-drug antibodies are associated with treatment response and drug survival in patients with inflammatory joint diseases: data from the NOR-DMARD study
Scand J Rheumatol, 50 (6), 445-454
DOI 10.1080/03009742.2021.1875040, PubMed 33650469
Infliximab clearance decreases in the second and third trimesters of pregnancy in inflammatory bowel disease
United European Gastroenterol J, 9 (1), 91-101
DOI 10.1177/2050640620964619, PubMed 33079627
Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction in Patients With Chronic Immune-Mediated Inflammatory Diseases-Reply
JAMA, 326 (11), 1069-1070
DOI 10.1001/jama.2021.11480, PubMed 34546304
Effect of Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction on Disease Remission in Patients With Chronic Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial
JAMA, 325 (17), 1744-1754
DOI 10.1001/jama.2021.4172, PubMed 33944876
Effect of Therapeutic Drug Monitoring vs Standard Therapy During Maintenance Infliximab Therapy on Disease Control in Patients With Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial
JAMA, 326 (23), 2375-2384
DOI 10.1001/jama.2021.21316, PubMed 34932077
Publications 2020
Therapeutic thresholds and mechanisms for primary non-response to infliximab in inflammatory bowel disease
Scand J Gastroenterol, 55 (8), 884-890
DOI 10.1080/00365521.2020.1786852, PubMed 32631131
The effect of infliximab in patients with chronic low back pain and Modic changes (the BackToBasic study): study protocol of a randomized, double blind, placebo-controlled, multicenter trial
BMC Musculoskelet Disord, 21 (1), 698
DOI 10.1186/s12891-020-03720-5, PubMed 33087100
Falsely markedly elevated 25-hydroxyvitamin D in patients with monoclonal gammopathies
Clin Chem Lab Med, 59 (4), 663-669
DOI 10.1515/cclm-2020-1411, PubMed 33119540
Efficacy and Safety of CT-P13 in Inflammatory Bowel Disease after Switching from Originator Infliximab: Exploratory Analyses from the NOR-SWITCH Main and Extension Trials
BioDrugs, 34 (5), 681-694
DOI 10.1007/s40259-020-00438-7, PubMed 32965617
Phase 1/2a study of 177Lu-lilotomab satetraxetan in relapsed/refractory indolent non-Hodgkin lymphoma
Blood Adv, 4 (17), 4091-4101
DOI 10.1182/bloodadvances.2020002583, PubMed 32877524
Maternal placental growth factor and soluble fms-like tyrosine kinase-1 reference ranges in post-term pregnancies: A prospective observational study
PLoS One, 15 (10), e0240473
DOI 10.1371/journal.pone.0240473, PubMed 33079955
Colorectal Cancer Screening With Repeated Fecal Immunochemical Test Versus Sigmoidoscopy: Baseline Results From a Randomized Trial
Gastroenterology, 160 (4), 1085-1096.e5
DOI 10.1053/j.gastro.2020.11.037, PubMed 33227280
Exploratory Analysis of CA125-MGL and -STn Glycoforms in the Differential Diagnostics of Pelvic Masses
J Appl Lab Med, 5 (2), 263-272
DOI 10.1093/jalm/jfz012, PubMed 32445385
Therapeutic drug monitoring of infliximab compared to standard clinical treatment with infliximab: study protocol for a randomised, controlled, open, parallel-group, phase IV study (the NOR-DRUM study)
Trials, 21 (1), 13
DOI 10.1186/s13063-019-3734-4, PubMed 31907007
OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation
Cell Rep, 30 (12), 4165-4178.e7
DOI 10.1016/j.celrep.2020.02.063, PubMed 32209476
Publications 2019
Real world data on effectiveness, safety and therapeutic drug monitoring of vedolizumab in patients with inflammatory bowel disease. A single center cohort
Scand J Gastroenterol, 54 (1), 41-48
DOI 10.1080/00365521.2018.1548646, PubMed 30650312
Determination of lower cut-off levels of adalimumab associated with biochemical remission in Crohn's disease
JGH Open, 4 (3), 410-416
DOI 10.1002/jgh3.12266, PubMed 32514446
Associations between certolizumab pegol serum levels, anti-drug antibodies and treatment response in patients with inflammatory joint diseases: data from the NOR-DMARD study
Arthritis Res Ther, 21 (1), 256
DOI 10.1186/s13075-019-2009-5, PubMed 31783773
Long-term efficacy and safety of biosimilar infliximab (CT-P13) after switching from originator infliximab: open-label extension of the NOR-SWITCH trial
J Intern Med, 285 (6), 653-669
DOI 10.1111/joim.12880, PubMed 30762274
A Fully Automated Method for the Determination of Serum Belatacept and Its Application in a Pharmacokinetic Investigation in Renal Transplant Recipients
Ther Drug Monit, 41 (1), 11-18
DOI 10.1097/FTD.0000000000000580, PubMed 30633722
Publications 2018
Subtherapeutic concentrations of infliximab and adalimumab are associated with increased disease activity in Crohn's disease
Therap Adv Gastroenterol, 11, 1756284818759930
DOI 10.1177/1756284818759930, PubMed 29623105
Drug concentrations and anti-drug antibodies during treatment with biosimilar infliximab (CT-P13) in routine care
Scand J Rheumatol, 47 (5), 418-421
DOI 10.1080/03009742.2017.1376110, PubMed 29310493
Switching from originator to biosimilar infliximab - real world data of a prospective 18 months follow-up of a single-centre IBD population
Scand J Gastroenterol, 53 (6), 692-699
DOI 10.1080/00365521.2018.1463391, PubMed 29852793
Auto-antibodies against the angiotensin II type I receptor in women with uteroplacental acute atherosis and preeclampsia at delivery and several years postpartum
J Reprod Immunol, 128, 23-29
DOI 10.1016/j.jri.2018.05.008, PubMed 29843114
Chronic fatigue is highly prevalent in survivors of autologous stem cell transplantation and associated with IL-6, neuroticism, cardiorespiratory fitness, and obesity
Bone Marrow Transplant, 54 (4), 607-610
DOI 10.1038/s41409-018-0342-y, PubMed 30262906
Prognostic role of carcinoembryonic antigen and carbohydrate antigen 19-9 in metastatic colorectal cancer: a BRAF-mutant subset with high CA 19-9 level and poor outcome
Br J Cancer, 118 (12), 1609-1616
DOI 10.1038/s41416-018-0115-9, PubMed 29872151
Pro-gastrin-releasing peptide and outcome in patients with heart failure and anaemia: results from the RED-HF study
ESC Heart Fail, 5 (6), 1052-1059
DOI 10.1002/ehf2.12312, PubMed 30145817
Publications 2017
Assays for Infliximab Drug Levels and Antibodies: A Matter of Scales and Categories
Scand J Immunol, 86 (3), 165-170
DOI 10.1111/sji.12572, PubMed 28561325
Cerebrospinal Fluid S100B and Alzheimer's Disease Biomarkers in Hip Fracture Patients with Delirium
Dement Geriatr Cogn Dis Extra, 7 (3), 374-385
DOI 10.1159/000481853, PubMed 29282410
Switching from originator infliximab to biosimilar CT-P13 compared with maintained treatment with originator infliximab (NOR-SWITCH): a 52-week, randomised, double-blind, non-inferiority trial
Lancet, 389 (10086), 2304-2316
DOI 10.1016/S0140-6736(17)30068-5, PubMed 28502609
Lowered reference limits for hCG improve follow-up of patients with hCG-producing tumors
Clin Biochem, 52, 73-79
DOI 10.1016/j.clinbiochem.2017.11.016, PubMed 29198759
Renal Function Influences Diagnostic Markers in Serum and Urine: A Study of Guanidinoacetate, Creatine, Human Epididymis Protein 4, and Neutrophil Gelatinase-Associated Lipocalin in Children
J Appl Lab Med, 2 (3), 297-308
DOI 10.1373/jalm.2016.022145, PubMed 33636843
Publications 2016
A unique set of 6 circulating microRNAs for early detection of non-small cell lung cancer
Oncotarget, 7 (24), 37250-37259
DOI 10.18632/oncotarget.9363, PubMed 27191990
Tomato-based randomized controlled trial in prostate cancer patients: Effect on PSA
Clin Nutr, 36 (3), 672-679
DOI 10.1016/j.clnu.2016.06.014, PubMed 27406859
Publications 2015
Perinatal Asphyxia May Influence the Level of Beta-Amyloid (1-42) in Cerebrospinal Fluid: An Experimental Study on Newborn Pigs
PLoS One, 10 (10), e0140966
DOI 10.1371/journal.pone.0140966, PubMed 26501201
HE4 as an Early Detection Biomarker of Epithelial Ovarian Cancer: Investigations in Prediagnostic Specimens From the Janus Serumbank
Int J Gynecol Cancer, 25 (9), 1608-15
DOI 10.1097/IGC.0000000000000532, PubMed 26501436
Publications 2013
Heterophilic antibody interference in immunometric assays
Best Pract Res Clin Endocrinol Metab, 27 (5), 647-61
DOI 10.1016/j.beem.2013.05.011, PubMed 24094636
Publications 2012
Belief is only half the truth--or why screening for heterophilic antibody interference in certain assays makes double sense
Ann Clin Biochem, 49 (Pt 4), 381-6
DOI 10.1258/acb.2012.011228, PubMed 22740684
A man with abdominal pain: enough evidence for surgery?
Clin Chem, 58 (8), 1187-90
DOI 10.1373/clinchem.2011.167015, PubMed 22843812
Heterophilic antibody interference in commercial immunoassays; a screening study using paired native and pre-blocked sera (vol 49, pg 2001, 2011)
Clin. Chem. Lab. Med., 50 (2), 409
DOI 10.1515/cclm-2012-0038
The Accu-Chek Mobile blood glucose monitoring system used under controlled conditions meets ISO 15197 standards in the hands of diabetes patients
Scand J Clin Lab Invest, 72 (5), 374-9
DOI 10.3109/00365513.2012.677544, PubMed 22900743
Publications 2011
Heterophilic antibody interference in commercial immunoassays; a screening study using paired native and pre-blocked sera
Clin Chem Lab Med, 49 (12), 2001-6
DOI 10.1515/CCLM.2011.702, PubMed 21899496
Human epididymis protein 4 reference limits and natural variation in a Nordic reference population
Tumour Biol, 33 (1), 141-8
DOI 10.1007/s13277-011-0256-4, PubMed 22105734
Publications 2008
Expression and purification of NEIL3, a human DNA glycosylase homolog
Protein Expr Purif, 65 (2), 160-4
DOI 10.1016/j.pep.2008.11.014, PubMed 19121397
Publications 2007
The capacity to remove 8-oxoG is enhanced in newborn neural stem/progenitor cells and decreases in juvenile mice and upon cell differentiation
DNA Repair (Amst), 6 (6), 723-32
DOI 10.1016/j.dnarep.2006.12.008, PubMed 17236821