Development and validation of immunoassays for novel immunotherapy drugs such as KEYTRUDA (pembrolizumab), OPDIVO (nivolumab) and YERVOY (ipilimumab), for monitoring drug levels in patients with lung cancer and malignant melanoma.
Developing assays for measuring different monoclonal antibodies used in the treatment of patients with autoimmune diseases. These assays are used in the clinical routine and in several ongoing clinical trials.
Detection of antibodies to transglutaminase in the HUNT4-cohort using an in-house dual label assay in collaborative study “Coeliac disease in HUNT”.
Late effects after testicular cancer; thyroid and kidney function, in collaboration with National Advisory Unit on Late Effects after Cancer Treatment.
Screening for patient antibodies to HH1, a novel antibody-based drug used in lymphoma clinical trials (Lymrit).
Part of the collaboration study “Hallmarks in lung cancer”; validating different markers for potential development of assays clinically useful indaily practice.
Investigating the potential effect of combinatorial treatment of melanoma with PLX4032 (vemurafenib) and HER antibodies (in vitro studies).
Validating immunoassays for human epidermal growth factor receptors 2, 3 and 4 as tumour markers for HER2 positive breast cancer.
Recent publications
Levernæs MCS, Farhat B, Oulie I, Abdullah SS, Paus E, Reubsaet L, Halvorsen TG(2019) Immunocapture sample clean-up in determination of low abundant protein biomarkers - a feasibility study of peptide capture by anti-protein antibodies RSC Adv, 9(60), 34902-34911 DOI 10.1039/c9ra05071j, PubMed 35702551
Klaasen RA, Warren DJ, Iversen R, Bolstad N, Andersen IL, Mjønes P, Rønne E, Lundin KEA, Sollid LM, Ness-Jensen E(2022) The development and validation of a high-capacity serological assay for celiac disease Clin Biochem(in press) DOI 10.1016/j.clinbiochem.2022.05.010, PubMed 35660483
Syversen SW, Jyssum I, Tveter AT, Tran TT, Sexton J, Provan SA, Mjaaland S, Warren DJ, Kvien TK, Grødeland G, Nissen-Meyer LSH, Ricanek P, Chopra A, Andersson AM, Kro GB, Jahnsen J, Munthe LA, Haavardsholm EA, Vaage JT, Lund-Johansen F, Jørgensen KK, Goll GL(2022) Immunogenicity and Safety of Standard and Third-Dose SARS-CoV-2 Vaccination in Patients Receiving Immunosuppressive Therapy Arthritis Rheumatol(in press) DOI 10.1002/art.42153, PubMed 35507355