The role of CD45 phosphatase activity and its regulation via natural ligands to control BCR signaling strength in normal B cell development
To decipher how the BCR signal strength controls fate decision of autoreactive clones in central and peripheral tolerance mechanisms in autoimmunity/autoimmune diseases
To delineate how the B cells proliferation capacity and longevity is -along with other factors- regulated by the BCR signaling strength in immunodeficiencies and hematological malignancies
To investigate CD45 phosphatase activity regulation of BCR signaling strength in the development of effective humoral immune response against viruses
Recent publications
Szodoray P, Andersen TK, Heinzelbecker J, Imbery JF, Huszthy PC, Stanford SM, Bogen B, Landsverk OB, Bottini N, Tveita A, Munthe LA, Nakken B(2021) Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity Cell Rep, 36(6), 109525 DOI 10.1016/j.celrep.2021.109525, PubMed 34380042
Papp G, Szabó K, Jámbor I, Mile M, Berki AR, Arany AC, Makra G, Szodoray P, Csiki Z, Balogh L(2021) Regular Exercise May Restore Certain Age-Related Alterations of Adaptive Immunity and Rebalance Immune Regulation Front Immunol, 12, 639308 DOI 10.3389/fimmu.2021.639308, PubMed 33936054
Szabó K, Jámbor I, Szántó A, Horváth IF, Tarr T, Nakken B, Szodoray P, Papp G(2021) The Imbalance of Circulating Follicular T Helper Cell Subsets in Primary Sjögren's Syndrome Associates With Serological Alterations and Abnormal B-Cell Distribution Front Immunol, 12, 639975 DOI 10.3389/fimmu.2021.639975, PubMed 33815392
Get in touch
Peter Szodoray Institute of Immunology, Rikshospitalet, Oslo University Hospital Sognsvannsveien 20., Section A2. 2nd. floor, Room: A3.2079, 0372 Oslo, Norway Phone: + 47 23 07 30 65 Cell: + 47 94 269082 Fax: + 47 23 07 35 10 Email: szodoray@gmail.com, peter.szodoray@medisin.uio.no, petszo@ous-hf.no