Research Projects

  • The role of CD45 phosphatase activity and its regulation via natural ligands to control BCR signaling strength in normal B cell development 
  • To decipher how the BCR signal strength controls fate decision of autoreactive clones in central and peripheral tolerance mechanisms in autoimmunity/autoimmune diseases 
  • To delineate how the B cells proliferation capacity and longevity is -along with other factors- regulated by the BCR signaling strength in immunodeficiencies and hematological malignancies
  • To investigate CD45 phosphatase activity regulation of BCR signaling strength in the development of effective humoral immune response against viruses     
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