The role of CD45 phosphatase activity and its regulation via natural ligands to control BCR signaling strength in normal B cell development
To decipher how the BCR signal strength controls fate decision of autoreactive clones in central and peripheral tolerance mechanisms in autoimmunity/autoimmune diseases
To delineate how the B cells proliferation capacity and longevity is -along with other factors- regulated by the BCR signaling strength in immunodeficiencies and hematological malignancies
To investigate CD45 phosphatase activity regulation of BCR signaling strength in the development of effective humoral immune response against viruses
Podgorica M, Drivet E, Viken JK, Richman A, Vestbøstad J, Szodoray P, Kvam AK, Wik HS, Tjønnfjord GE, Munthe LA, Frietze S, Schjerven H(2024) Transcriptome analysis of primary adult B-cell lineage acute lymphoblastic leukemia identifies pathogenic variants and gene fusions, and predicts subtypes for in depth molecular diagnosis Eur J Haematol, 112(5), 731-742 DOI 10.1111/ejh.14164, PubMed 38192186
Balogh L, Szabó K, Pucsok JM, Jámbor I, Gyetvai Á, Mile M, Barna L, Szodoray P, Tarr T, Csiki Z, Papp G(2022) The Effect of Aerobic Exercise and Low-Impact Pilates Workout on the Adaptive Immune System J Clin Med, 11(22) DOI 10.3390/jcm11226814, PubMed 36431291
Dunlock VE, Arp AB, Singh SP, Charrin S, Nguyen V, Jansen E, Schaper F, Beest MT, Zuidscherwoude M, van Deventer SJ, Nakken B, Szodoray P, Demaria MC, Wright MD, Querol Cano L, Rubinstein E, van Spriel AB(2022) Tetraspanin CD53 controls T cell immunity through regulation of CD45RO stability, mobility, and function Cell Rep, 39(13), 111006 DOI 10.1016/j.celrep.2022.111006, PubMed 35767951
Get in touch
Peter Szodoray Institute of Immunology, Rikshospitalet, Oslo University Hospital Sognsvannsveien 20., Section A2. 2nd. floor, Room: A3.2079, 0372 Oslo, Norway Phone: + 47 23 07 30 65 Cell: + 47 94 269082 Fax: + 47 23 07 35 10 Email: szodoray@gmail.com, peter.szodoray@medisin.uio.no, petszo@ous-hf.no