Publications
Publications from OUS - Cellular membrane dynamics (Stenmark)
753 publications found
Publications 2024
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Bi-allelic variants in SNF8 cause a disease spectrum ranging from severe developmental and epileptic encephalopathy to syndromic optic atrophy
Am J Hum Genet, 111 (3), 594-613
DOI 10.1016/j.ajhg.2024.02.005, PubMed 38423010 -
Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity
Nat Immunol, 25 (5), 834-846
DOI 10.1038/s41590-024-01802-3, PubMed 38561495 -
Clathrin controls bidirectional communication between T cells and antigen presenting cells
Bioessays, 46 (4), e2300230
DOI 10.1002/bies.202300230, PubMed 38412391 -
Elucidating the power of arginine restriction: taming type I interferon response in breast cancer via selective autophagy
Cell Commun Signal, 22 (1), 481
DOI 10.1186/s12964-024-01858-6, PubMed 39380098 -
From sweat to hope: The role of exercise-induced extracellular vesicles in cancer prevention and treatment
J Extracell Vesicles, 13 (8), e12500
DOI 10.1002/jev2.12500, PubMed 39183543 -
Omegasomes control formation, expansion, and closure of autophagosomes
Bioessays, 46 (6), e2400038
DOI 10.1002/bies.202400038, PubMed 38724256 -
Transmembrane domain-driven PD-1 dimers mediate T cell inhibition
Sci Immunol, 9 (93), eade6256
DOI 10.1126/sciimmunol.ade6256, PubMed 38457513 -
Lysophagy prevents neurotoxic aggregate transmission
Proc Natl Acad Sci U S A, 121 (3), e2321181121
DOI 10.1073/pnas.2321181121, PubMed 38190545 -
Entry of nanoparticles into cells and tissues: status and challenges
Beilstein J Nanotechnol, 15, 1017-1029
DOI 10.3762/bjnano.15.83, PubMed 39161463 -
Pitfalls in lipid mass spectrometry of mammalian samples - a brief guide for biologists
Nat Rev Mol Cell Biol, 25 (10), 759-760
DOI 10.1038/s41580-024-00758-4, PubMed 38951702 -
The E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation
Cell Mol Life Sci, 81 (1), 171
DOI 10.1007/s00018-024-05165-8, PubMed 38597989 -
Preclinical Efficacy of Cabazitaxel Loaded Poly(2-alkyl cyanoacrylate) Nanoparticle Variants
Int J Nanomedicine, 19, 3009-3029
DOI 10.2147/IJN.S450283, PubMed 38562610 -
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
J Extracell Vesicles, 13 (2), e12404
DOI 10.1002/jev2.12404, PubMed 38326288 -
Intercellular transfer of cancer cell invasiveness via endosome-mediated protease shedding
Nat Commun, 15 (1), 1277
DOI 10.1038/s41467-024-45558-8, PubMed 38341434 -
A dual-purpose fusion complex in autophagy
Cell Res, 34 (3), 183-184
DOI 10.1038/s41422-023-00925-w, PubMed 38228880 -
Exosome regulation by Rubicon in ageing
Nat Cell Biol, 26 (9), 1380-1381
DOI 10.1038/s41556-024-01482-z, PubMed 39174741
Publications 2023
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Plasma and urinary extracellular vesicles as a source of RNA biomarkers for prostate cancer in liquid biopsies
Front Mol Biosci, 10, 980433
DOI 10.3389/fmolb.2023.980433, PubMed 36818049 -
Dynamics and spatial organization of Kv1.3 at the immunological synapse of human CD4+ T cells
Biophys J, 123 (15), 2271-2281
DOI 10.1016/j.bpj.2023.08.011, PubMed 37596785 -
The Lysosomal Calcium Channel TRPML1 Maintains Mitochondrial Fitness in NK Cells through Interorganelle Cross-Talk
J Immunol, 211 (9), 1348-1358
DOI 10.4049/jimmunol.2300406, PubMed 37737664 -
Protrudin-mediated ER-endosome contact sites promote phagocytosis
Cell Mol Life Sci, 80 (8), 216
DOI 10.1007/s00018-023-04862-0, PubMed 37468729 -
siRNA screening reveals that SNAP29 contributes to exosome release
Cell Mol Life Sci, 80 (7), 177
DOI 10.1007/s00018-023-04822-8, PubMed 37285022 -
Automated tracking of cell migration in phase contrast images with CellTraxx
Sci Rep, 13 (1), 22982
DOI 10.1038/s41598-023-50227-9, PubMed 38151514 -
The separate axes of TECPR1 and ATG16L1 in CASM
Autophagy, 20 (1), 214-215
DOI 10.1080/15548627.2023.2255462, PubMed 37676042 -
TECPR1 is activated by damage-induced sphingomyelin exposure to mediate noncanonical autophagy
EMBO J, 42 (17), e113105
DOI 10.15252/embj.2022113105, PubMed 37409525 -
Clathrin mediates both internalization and vesicular release of triggered T cell receptor at the immunological synapse
Proc Natl Acad Sci U S A, 120 (6), e2211368120
DOI 10.1073/pnas.2211368120, PubMed 36730202 -
Intracellular FGF1 protects cells from apoptosis through direct interaction with p53
Cell Mol Life Sci, 80 (10), 311
DOI 10.1007/s00018-023-04964-9, PubMed 37783936 -
Opposite and dynamic regulation of the interferon response in metastatic and non-metastatic breast cancer
Cell Commun Signal, 21 (1), 50
DOI 10.1186/s12964-023-01062-y, PubMed 36882786 -
Removal of hypersignaling endosomes by simaphagy
Autophagy, 20 (4), 769-791
DOI 10.1080/15548627.2023.2267958, PubMed 37840274 -
Microbiota-Associated HAF-EVs Regulate Monocytes by Triggering or Inhibiting Inflammasome Activation
Int J Mol Sci, 24 (3)
DOI 10.3390/ijms24032527, PubMed 36768851 -
ATPase activity of DFCP1 controls selective autophagy
Nat Commun, 14 (1), 4051
DOI 10.1038/s41467-023-39641-9, PubMed 37422481 -
ATPase-regulated autophagosome biogenesis
Autophagy, 20 (1), 218-219
DOI 10.1080/15548627.2023.2255967, PubMed 37722386 -
BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes
Circ Res, 132 (11), e188-e205
DOI 10.1161/CIRCRESAHA.122.321732, PubMed 37139790 -
Vesicle-mediated transport of ALIX and ESCRT-III to the intercellular bridge during cytokinesis
Cell Mol Life Sci, 80 (8), 235
DOI 10.1007/s00018-023-04864-y, PubMed 37523003 -
Lipid Biomarkers in Liquid Biopsies: Novel Opportunities for Cancer Diagnosis
Pharmaceutics, 15 (2)
DOI 10.3390/pharmaceutics15020437, PubMed 36839759 -
Modulation of lytic molecules restrain serial killing in γδ T lymphocytes
Nat Commun, 14 (1), 6035
DOI 10.1038/s41467-023-41634-7, PubMed 37758698 -
The expanding organelle lipidomes: current knowledge and challenges
Cell Mol Life Sci, 80 (8), 237
DOI 10.1007/s00018-023-04889-3, PubMed 37530856 -
Lipids in Extracellular Vesicles: What Can Be Learned about Membrane Structure and Function?
Cold Spring Harb Perspect Biol, 15 (8)
DOI 10.1101/cshperspect.a041415, PubMed 37277192 -
The GCN2/eIF2αK stress kinase regulates PP1 to ensure mitotic fidelity
EMBO Rep, 24 (8), e56100
DOI 10.15252/embr.202256100, PubMed 37291955 -
Endocytic trafficking of connexins in cancer pathogenesis
Biochim Biophys Acta Mol Basis Dis, 1869 (7), 166812
DOI 10.1016/j.bbadis.2023.166812, PubMed 37454772 -
CSPP1 stabilizes growing microtubule ends and damaged lattices from the luminal side
J Cell Biol, 222 (4)
DOI 10.1083/jcb.202208062, PubMed 36752787 -
The quick reference card "Storage of urinary EVs" - A practical guideline tool for research and clinical laboratories
J Extracell Vesicles, 12 (3), e12286
DOI 10.1002/jev2.12286, PubMed 36916183 -
Autophagosome Biogenesis
Cells, 12 (4)
DOI 10.3390/cells12040668, PubMed 36831335 -
A phosphoinositide kinase triggers migrasome formation
Cell Res, 33 (8), 577-578
DOI 10.1038/s41422-023-00822-2, PubMed 37165066
Publications 2022
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Protrudin regulates FAK activation, endothelial cell migration and angiogenesis
Cell Mol Life Sci, 79 (4), 220
DOI 10.1007/s00018-022-04251-z, PubMed 35368213 -
Extracellular Vesicles as Novel Players in Kidney Disease
J Am Soc Nephrol, 33 (3), 467-471
DOI 10.1681/ASN.2021091232, PubMed 35131841 -
SILAC-based quantitative proteomics and microscopy analysis of cancer cells treated with the N-glycolyl GM3-specific anti-tumor antibody 14F7
Front Immunol, 13, 994790
DOI 10.3389/fimmu.2022.994790, PubMed 36439103 -
Extracellular vesicles and microRNAs are altered in response to exercise, insulin sensitivity and overweight
Acta Physiol (Oxf), 236 (4), e13862
DOI 10.1111/apha.13862, PubMed 36377504 -
Measuring Autophagic Cargo Flux with Keima-Based Probes
Methods Mol Biol, 2445, 99-115
DOI 10.1007/978-1-0716-2071-7_7, PubMed 34972988 -
Photodynamic Effects with 5-Aminolevulinic Acid on Cytokines and Exosomes in Human Peripheral Blood Mononuclear Cells
Biomedicines, 10 (2)
DOI 10.3390/biomedicines10020232, PubMed 35203441 -
Strategies to inhibit FGFR4 V550L-driven rhabdomyosarcoma
Br J Cancer, 127 (11), 1939-1953
DOI 10.1038/s41416-022-01973-6, PubMed 36097178 -
3D-Structured Illumination Microscopy of Centrosomes in Human Cell Lines
Bio Protoc, 12 (6), e4360
DOI 10.21769/BioProtoc.4360, PubMed 35434191 -
Corrigendum to "Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft", [Journal of Control Release, 293 (2019) 183-192]
J Control Release, 349, 1
DOI 10.1016/j.jconrel.2022.06.040, PubMed 35792388 -
TRIM27 is an autophagy substrate facilitating mitochondria clustering and mitophagy via phosphorylated TBK1
FEBS J, 290 (4), 1096-1116
DOI 10.1111/febs.16628, PubMed 36111389 -
Nuclear Localization Sequence of FGF1 Is Not Required for Its Intracellular Anti-Apoptotic Activity in Differentiated Cells
Cells, 11 (3)
DOI 10.3390/cells11030522, PubMed 35159330 -
PHLPP1 regulates CFTR activity and lumen expansion through AMPK
Development, 149 (20)
DOI 10.1242/dev.200955, PubMed 35997536 -
FGF-FGFR signaling promotes the development of invasive cervical cancer
FEBS J, 289 (12), 3419-3421
DOI 10.1111/febs.16384, PubMed 35146913 -
Amniotic fluid stem cell-derived extracellular vesicles are independent metabolic units capable of modulating inflammasome activation in THP-1 cells
FASEB J, 36 (4), e22218
DOI 10.1096/fj.202101657R, PubMed 35218567 -
ESCRTed resistance to T cell attack
Trends Immunol, 43 (8), 598-600
DOI 10.1016/j.it.2022.06.007, PubMed 35810056 -
Biophysical and molecular mechanisms of ESCRT functions, and their implications for disease
Curr Opin Cell Biol, 75, 102062
DOI 10.1016/j.ceb.2022.01.007, PubMed 35248976 -
The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics
Nat Commun, 13 (1), 6283
DOI 10.1038/s41467-022-33933-2, PubMed 36270994 -
Are doping tests in sports trustworthy?: Athletes suffer from insufficiently defined criteria for doping tests: Athletes suffer from insufficiently defined criteria for doping tests
EMBO Rep, 23 (3), e54431
DOI 10.15252/embr.202154431, PubMed 35156749 -
Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair
EMBO J, 41 (24), e112677
DOI 10.15252/embj.2022112677, PubMed 36408828 -
Integrin α11β1 and syndecan-4 dual receptor ablation attenuate cardiac hypertrophy in the pressure overloaded heart
Am J Physiol Heart Circ Physiol, 322 (6), H1057-H1071
DOI 10.1152/ajpheart.00635.2021, PubMed 35522553 -
Modulation of Ricin Intoxication by the Autophagy Inhibitor EACC
Toxins (Basel), 14 (5)
DOI 10.3390/toxins14050360, PubMed 35622606 -
Biodistribution, pharmacokinetics and excretion studies of intravenously injected nanoparticles and extracellular vesicles: Possibilities and challenges
Adv Drug Deliv Rev, 186, 114326
DOI 10.1016/j.addr.2022.114326, PubMed 35588953 -
Need for more focus on lipid species in studies of biological and model membranes
Prog Lipid Res, 86, 101160
DOI 10.1016/j.plipres.2022.101160, PubMed 35288150 -
ER as master regulator of membrane trafficking and organelle function
J Cell Biol, 221 (10)
DOI 10.1083/jcb.202205135, PubMed 36108241 -
ER-endosome contacts master the ins and outs of secretory endosomes
J Cell Biol, 221 (12)
DOI 10.1083/jcb.202210033, PubMed 36355088 -
On the surface-to-bulk partition of proteins in extracellular vesicles
Colloids Surf B Biointerfaces, 218, 112728
DOI 10.1016/j.colsurfb.2022.112728, PubMed 35969923
Publications 2021
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Wetting regulates autophagy of phase-separated compartments and the cytosol
Nature, 591 (7848), 142-146
DOI 10.1038/s41586-020-2992-3, PubMed 33473217 -
Cosegregation of asymmetric features during cell division
Open Biol, 11 (8), 210116
DOI 10.1098/rsob.210116, PubMed 34343465 -
FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability
Commun Biol, 4 (1), 127
DOI 10.1038/s42003-021-01647-8, PubMed 33514811 -
Host autophagy mediates organ wasting and nutrient mobilization for tumor growth
EMBO J, 40 (18), e107336
DOI 10.15252/embj.2020107336, PubMed 34309071 -
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
Autophagy, 17 (1), 1-382
DOI 10.1080/15548627.2020.1797280, PubMed 33634751 -
Fibroblast Growth Factor 2 Conjugated with Monomethyl Auristatin E Inhibits Tumor Growth in a Mouse Model
Biomacromolecules, 22 (10), 4169-4180
DOI 10.1021/acs.biomac.1c00662, PubMed 34542998 -
GAK and PRKCD are positive regulators of PRKN-independent mitophagy
Nat Commun, 12 (1), 6101
DOI 10.1038/s41467-021-26331-7, PubMed 34671015 -
Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines
iScience, 24 (7), 102807
DOI 10.1016/j.isci.2021.102807, PubMed 34337362 -
Effects of a Unique Combination of the Whole-Body Low Dose Radiotherapy with Inactivation of Two Immune Checkpoints and/or a Heat Shock Protein on the Transplantable Lung Cancer in Mice
Int J Mol Sci, 22 (12)
DOI 10.3390/ijms22126309, PubMed 34208396 -
The phosphatidylinositol 3-phosphate-binding protein SNX4 controls ATG9A recycling and autophagy
J Cell Sci, 134 (3)
DOI 10.1242/jcs.250670, PubMed 33468622 -
The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes
Nat Commun, 12 (1), 6577
DOI 10.1038/s41467-021-26775-x, PubMed 34772942 -
Should I bend or should I grow: the mechanisms of droplet-mediated autophagosome formation
Autophagy, 17 (4), 1046-1048
DOI 10.1080/15548627.2021.1887548, PubMed 33629888 -
Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling
Cells, 10 (6)
DOI 10.3390/cells10061342, PubMed 34071546 -
First person - Kia Wee Tan
J. Cell Sci., 134 (14), jcs259055
DOI 10.1242/jcs.259055 -
JIP4 is recruited by the phosphoinositide-binding protein Phafin2 to promote recycling tubules on macropinosomes
J Cell Sci, 134 (14)
DOI 10.1242/jcs.258495, PubMed 34109410 -
Adaptation to hypoxia in Drosophila melanogaster requires autophagy
Autophagy, 18 (4), 909-920
DOI 10.1080/15548627.2021.1991191, PubMed 34793268 -
Inhibiting autophagy increases the efficacy of low-dose photodynamic therapy
Biochem Pharmacol, 194, 114837
DOI 10.1016/j.bcp.2021.114837, PubMed 34780750 -
Roles of the FGF-FGFR Signaling System in Cancer Development and Inflammation
Cells, 10 (9)
DOI 10.3390/cells10092231, PubMed 34571880 -
The GAS6-AXL signaling pathway triggers actin remodeling that drives membrane ruffling, macropinocytosis, and cancer-cell invasion
Proc Natl Acad Sci U S A, 118 (28)
DOI 10.1073/pnas.2024596118, PubMed 34244439 -
Sealing holes in cellular membranes
EMBO J, 40 (7), e106922
DOI 10.15252/embj.2020106922, PubMed 33644904
Publications 2020
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Colorectal cysts as a validating tool for CAR therapy
BMC Biotechnol, 20 (1), 30
DOI 10.1186/s12896-020-00623-0, PubMed 32487146 -
Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake
Nat Commun, 11 (1), 440
DOI 10.1038/s41467-020-14343-8, PubMed 31974402 -
FGF2-Derived PeptibodyF2-MMAE Conjugate for Targeted Delivery of Cytotoxic Drugs into Cancer Cells Overexpressing FGFR1
Cancers (Basel), 12 (10)
DOI 10.3390/cancers12102992, PubMed 33076489 -
RabX1 Organizes a Late Endosomal Compartment that Forms Tubular Connections to Lysosomes Consistent with a "Kiss and Run" Mechanism
Curr Biol, 30 (7), 1177-1188.e5
DOI 10.1016/j.cub.2020.01.048, PubMed 32059769 -
Protein crowding mediates membrane remodeling in upstream ESCRT-induced formation of intraluminal vesicles
Proc Natl Acad Sci U S A, 117 (46), 28614-28624
DOI 10.1073/pnas.2014228117, PubMed 33139578 -
Clathrin regulates Wnt/β-catenin signaling by affecting Golgi to plasma membrane transport of transmembrane proteins
J Cell Sci, 133 (13)
DOI 10.1242/jcs.244467, PubMed 32546530 -
Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy
EMBO J, 39 (24), e104948
DOI 10.15252/embj.2020104948, PubMed 33226137 -
Dual Targeting of BRAF and mTOR Signaling in Melanoma Cells with Pyridinyl Imidazole Compounds
Cancers (Basel), 12 (6)
DOI 10.3390/cancers12061516, PubMed 32531927 -
Protrudin-mediated ER-endosome contact sites promote MT1-MMP exocytosis and cell invasion
J Cell Biol, 219 (8)
DOI 10.1083/jcb.202003063, PubMed 32479595 -
LRRK2 to the rescue of damaged endomembranes
EMBO J, 39 (18), e106162
DOI 10.15252/embj.2020106162, PubMed 32803793 -
Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation
Nat Cell Biol, 22 (7), 856-867
DOI 10.1038/s41556-020-0537-5, PubMed 32601372 -
Photochemically-Induced Release of Lysosomal Sequestered Sunitinib: Obstacles for Therapeutic Efficacy
Cancers (Basel), 12 (2)
DOI 10.3390/cancers12020417, PubMed 32053965 -
STEEP mediates STING ER exit and activation of signaling
Nat Immunol, 21 (8), 868-879
DOI 10.1038/s41590-020-0730-5, PubMed 32690950 -
Author Correction: STEEP mediates STING ER exit and activation of signaling
Nat Immunol, 21 (11), 1468-1469
DOI 10.1038/s41590-020-0803-5, PubMed 32929276
Publications 2019
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Transcription-mediated organization of the replication initiation program across large genes sets common fragile sites genome-wide
Nat Commun, 10 (1), 5693
DOI 10.1038/s41467-019-13674-5, PubMed 31836700 -
A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling
Cell Rep, 28 (7), 1907-1922.e6
DOI 10.1016/j.celrep.2019.07.025, PubMed 31412255 -
Remodeling of secretory lysosomes during education tunes functional potential in NK cells
Nat Commun, 10 (1), 514
DOI 10.1038/s41467-019-08384-x, PubMed 30705279 -
The FMRpolyGlycine Protein Mediates Aggregate Formation and Toxicity Independent of the CGG mRNA Hairpin in a Cellular Model for FXTAS
Front Genet, 10, 249
DOI 10.3389/fgene.2019.00249, PubMed 30984240 -
Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites
Nat Commun, 10 (1), 4176
DOI 10.1038/s41467-019-12094-9, PubMed 31519908 -
Centralspindlin Recruits ALIX to the Midbody during Cytokinetic Abscission in Drosophila via a Mechanism Analogous to Virus Budding
Curr Biol, 29 (20), 3538-3548.e7
DOI 10.1016/j.cub.2019.09.025, PubMed 31607533 -
The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress
J Biol Chem, 294 (20), 8197-8217
DOI 10.1074/jbc.RA118.002829, PubMed 30926605 -
Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth
Elife, 8
DOI 10.7554/eLife.51063, PubMed 31868590 -
Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma
Oncogene, 38 (50), 7473-7490
DOI 10.1038/s41388-019-0956-6, PubMed 31444413 -
CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor
PLoS Biol, 17 (4), e2007044
DOI 10.1371/journal.pbio.2007044, PubMed 30933966 -
The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2
PLoS Pathog, 15 (3), e1007684
DOI 10.1371/journal.ppat.1007684, PubMed 30883606 -
WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling
Nat Commun, 10 (1), 2850
DOI 10.1038/s41467-019-10794-w, PubMed 31253801 -
Tumor suppression by control of matrix metalloproteinase recycling
Mol Cell Oncol, 6 (6), e1646606
DOI 10.1080/23723556.2019.1646606, PubMed 31692886 -
Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1/2 Pathway
Cells, 8 (6)
DOI 10.3390/cells8060518, PubMed 31146385 -
Simultaneous defeat of MCF7 and MDA-MB-231 resistances by a hypericin PDT-tamoxifen hybrid therapy
NPJ Breast Cancer, 5, 13
DOI 10.1038/s41523-019-0108-8, PubMed 30993194 -
The many functions of ESCRTs
Nat Rev Mol Cell Biol, 21 (1), 25-42
DOI 10.1038/s41580-019-0177-4, PubMed 31705132 -
Crosstalk between p38 and Erk 1/2 in Downregulation of FGF1-Induced Signaling
Int J Mol Sci, 20 (8)
DOI 10.3390/ijms20081826, PubMed 31013829 -
ESCRT-mediated phagophore sealing during mitophagy
Autophagy, 16 (5), 826-841
DOI 10.1080/15548627.2019.1639301, PubMed 31366282
Publications 2018
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Gamma irradiation during gametogenesis in young adult zebrafish causes persistent genotoxicity and adverse reproductive effects
Ecotoxicol Environ Saf, 154, 19-26
DOI 10.1016/j.ecoenv.2018.02.031, PubMed 29453161 -
Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors
Mol Cell Proteomics, 17 (5), 850-870
DOI 10.1074/mcp.RA117.000538, PubMed 29371290 -
Translocation of Exogenous FGF1 and FGF2 Protects the Cell against Apoptosis Independently of Receptor Activation
J Mol Biol, 430 (21), 4087-4101
DOI 10.1016/j.jmb.2018.08.004, PubMed 30099027 -
Centrosomal ALIX regulates mitotic spindle orientation by modulating astral microtubule dynamics
EMBO J, 37 (13)
DOI 10.15252/embj.201797741, PubMed 29858227 -
Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy
J Cell Biol, 217 (10), 3640-3655
DOI 10.1083/jcb.201711002, PubMed 30018090 -
The tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology
Biol Res, 51 (1), 3
DOI 10.1186/s40659-017-0151-6, PubMed 29316982 -
Endosomal microautophagy is an integrated part of the autophagic response to amino acid starvation
Autophagy, 15 (1), 182-183
DOI 10.1080/15548627.2018.1532265, PubMed 30295124 -
ESCRT-mediated lysosome repair precedes lysophagy and promotes cell survival
EMBO J, 37 (21)
DOI 10.15252/embj.201899753, PubMed 30314966 -
ESCRTs in membrane sealing
Biochem Soc Trans, 46 (4), 773-778
DOI 10.1042/BST20170435, PubMed 29903934 -
Orchestrating Nuclear Envelope Sealing during Mitosis
Dev Cell, 47 (5), 541-542
DOI 10.1016/j.devcel.2018.11.020, PubMed 30513298 -
Concerted ESCRT and clathrin recruitment waves define the timing and morphology of intraluminal vesicle formation
Nat Commun, 9 (1), 2932
DOI 10.1038/s41467-018-05345-8, PubMed 30050131 -
Proximity Labeling by a Recombinant APEX2-FGF1 Fusion Protein Reveals Interaction of FGF1 with the Proteoglycans CD44 and CSPG4
Biochemistry, 57 (26), 3807-3816
DOI 10.1021/acs.biochem.8b00120, PubMed 29812912
Publications 2017
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Exogenous lysophospholipids with large head groups perturb clathrin-mediated endocytosis
Traffic, 18 (3), 176-191
DOI 10.1111/tra.12468, PubMed 28067430 -
ErbB3 interacts with Hrs and is sorted to lysosomes for degradation
Biochim Biophys Acta Mol Cell Res, 1864 (12), 2241-2252
DOI 10.1016/j.bbamcr.2017.08.011, PubMed 28867611 -
PtdIns3P controls mTORC1 signaling through lysosomal positioning
J Cell Biol, 216 (12), 4217-4233
DOI 10.1083/jcb.201611073, PubMed 29030394 -
Microenvironmental autophagy promotes tumour growth
Nature, 541 (7637), 417-420
DOI 10.1038/nature20815, PubMed 28077876 -
Microenvironment and tumors-a nurturing relationship
Autophagy, 13 (7), 1241-1243
DOI 10.1080/15548627.2017.1310361, PubMed 28632995 -
Cytotoxic Conjugates of Fibroblast Growth Factor 2 (FGF2) with Monomethyl Auristatin E for Effective Killing of Cells Expressing FGF Receptors
ACS Omega, 2 (7), 3792-3805
DOI 10.1021/acsomega.7b00116, PubMed 30023704 -
Visualization of PML nuclear import complexes reveals FG-repeat nucleoporins at cargo retrieval sites
Nucleus, 8 (4), 404-420
DOI 10.1080/19491034.2017.1306161, PubMed 28402725 -
Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation
Nat Cell Biol, 19 (12), 1412-1423
DOI 10.1038/ncb3631, PubMed 29084199 -
Development of resistance to photodynamic therapy (PDT) in human breast cancer cells is photosensitizer-dependent: Possible mechanisms and approaches for overcoming PDT-resistance
Biochem Pharmacol, 144, 63-77
DOI 10.1016/j.bcp.2017.08.002, PubMed 28784290 -
Suppressing mTORC1 on the lysosome
EMBO J, 36 (13), 1809-1810
DOI 10.15252/embj.201797469, PubMed 28623241 -
Targeting Tankyrase to Fight WNT-dependent Tumours
Basic Clin Pharmacol Toxicol, 121 (2), 81-88
DOI 10.1111/bcpt.12786, PubMed 28371398 -
Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and β-Catenin Degradation
PLoS One, 12 (1), e0170508
DOI 10.1371/journal.pone.0170508, PubMed 28107521 -
The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions
J Cell Sci, 130 (17), 2867-2882
DOI 10.1242/jcs.202408, PubMed 28733455
Publications 2016
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Novel ESCRT functions in cell biology: spiraling out of control?
Curr Opin Cell Biol, 41, 1-8
DOI 10.1016/j.ceb.2016.03.008, PubMed 27031044 -
Cellular Functions and Molecular Mechanisms of the ESCRT Membrane-Scission Machinery
Trends Biochem Sci, 42 (1), 42-56
DOI 10.1016/j.tibs.2016.08.016, PubMed 27669649 -
ALIX and ESCRT-I/II function as parallel ESCRT-III recruiters in cytokinetic abscission
J Cell Biol, 212 (5), 499-513
DOI 10.1083/jcb.201507009, PubMed 26929449 -
Mitotic cells form actin-based bridges with adjacent cells to provide intercellular communication during rounding
Cell Cycle, 15 (21), 2943-2957
DOI 10.1080/15384101.2016.1231280, PubMed 27625181 -
Effects of perfluorinated alkyl acids on cellular responses of MCF-10A mammary epithelial cells in monolayers and on acini formation in vitro
Toxicol Lett, 259, 95-107
DOI 10.1016/j.toxlet.2016.08.004, PubMed 27511595 -
Proximity Labeling Reveals Molecular Determinants of FGFR4 Endosomal Transport
J Proteome Res, 15 (10), 3841-3855
DOI 10.1021/acs.jproteome.6b00652, PubMed 27615514 -
PIKfyve inhibition increases exosome release and induces secretory autophagy
Cell Mol Life Sci, 73 (24), 4717-4737
DOI 10.1007/s00018-016-2309-8, PubMed 27438886 -
HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels
Nat Commun, 7, 13889
DOI 10.1038/ncomms13889, PubMed 28004827 -
Antibody Staining in Drosophila Germaria
Methods Mol Biol, 1457, 19-33
DOI 10.1007/978-1-4939-3795-0_3, PubMed 27557571 -
Focusing the Spotlight on the Zebrafish Intestine to Illuminate Mechanisms of Colorectal Cancer
Adv Exp Med Biol, 916, 411-37
DOI 10.1007/978-3-319-30654-4_18, PubMed 27165364 -
ESCRT proteins restrict constitutive NF-κB signaling by trafficking cytokine receptors
Sci Signal, 9 (411), ra8
DOI 10.1126/scisignal.aad0848, PubMed 26787452 -
TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation
J Cell Sci, 129 (19), 3562-3573
DOI 10.1242/jcs.190017, PubMed 27562068 -
The Abscission Checkpoint: Making It to the Final Cut
Trends Cell Biol, 27 (1), 1-11
DOI 10.1016/j.tcb.2016.10.001, PubMed 27810282 -
Formation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity
PLoS One, 11 (8), e0160507
DOI 10.1371/journal.pone.0160507, PubMed 27482906 -
Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer
Nat Commun, 7, 10318
DOI 10.1038/ncomms10318, PubMed 26754771 -
Plasma membrane repairs by small GTPase Rab3a
J Cell Biol, 213 (6), 613-5
DOI 10.1083/jcb.201606006, PubMed 27325788 -
Phosphoinositides in membrane contact sites
Biochem Soc Trans, 44 (2), 425-30
DOI 10.1042/BST20150190, PubMed 27068950 -
ER-endosome contact sites in endosome positioning and protrusion outgrowth
Biochem Soc Trans, 44 (2), 441-6
DOI 10.1042/BST20150246, PubMed 27068952 -
Phosphoinositides in Control of Membrane Dynamics
Annu Rev Cell Dev Biol, 32, 143-171
DOI 10.1146/annurev-cellbio-111315-125349, PubMed 27576122 -
Genetic Screen in Drosophila Larvae Links ird1 Function to Toll Signaling in the Fat Body and Hemocyte Motility
PLoS One, 11 (7), e0159473
DOI 10.1371/journal.pone.0159473, PubMed 27467079 -
Arv1 promotes cell division by recruiting IQGAP1 and myosin to the cleavage furrow
Cell Cycle, 15 (5), 628-43
DOI 10.1080/15384101.2016.1146834, PubMed 27104745 -
Interaction with epsin 1 regulates the constitutive clathrin-dependent internalization of ErbB3
Biochim Biophys Acta, 1863 (6 Pt A), 1179-88
DOI 10.1016/j.bbamcr.2016.03.011, PubMed 26975582 -
Closing a gap in the nuclear envelope
Curr Opin Cell Biol, 40, 90-97
DOI 10.1016/j.ceb.2016.03.001, PubMed 27016712
Publications 2015
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Surface Trafficking of APP and BACE in Live Cells
Traffic, 16 (6), 655-75
DOI 10.1111/tra.12270, PubMed 25712587 -
Instability restricts signaling of multiple fibroblast growth factors
Cell Mol Life Sci, 72 (12), 2445-59
DOI 10.1007/s00018-015-1856-8, PubMed 25854632 -
Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy
Autophagy, 11 (9), 1458-70
DOI 10.1080/15548627.2015.1067359, PubMed 26207339 -
Enrichment of nuclear S100A4 during G2/M in colorectal cancer cells: possible association with cyclin B1 and centrosomes
Clin Exp Metastasis, 32 (8), 755-67
DOI 10.1007/s10585-015-9742-1, PubMed 26349943 -
ALIX and ESCRT-III coordinately control cytokinetic abscission during germline stem cell division in vivo
PLoS Genet, 11 (1), e1004904
DOI 10.1371/journal.pgen.1004904, PubMed 25635693 -
Src64 controls a novel actin network required for proper ring canal formation in the Drosophila male germline
Development, 142 (23), 4107-18
DOI 10.1242/dev.124370, PubMed 26628094 -
Dynamic Escherichia coli SeqA complexes organize the newly replicated DNA at a considerable distance from the replisome
Nucleic Acids Res, 43 (5), 2730-43
DOI 10.1093/nar/gkv146, PubMed 25722374 -
p62/Sequestosome-1, Autophagy-related Gene 8, and Autophagy in Drosophila Are Regulated by Nuclear Factor Erythroid 2-related Factor 2 (NRF2), Independent of Transcription Factor TFEB
J Biol Chem, 290 (24), 14945-62
DOI 10.1074/jbc.M115.656116, PubMed 25931115 -
Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth
Nature, 520 (7546), 234-8
DOI 10.1038/nature14359, PubMed 25855459 -
ER-endosome contact sites: molecular compositions and functions
EMBO J, 34 (14), 1848-58
DOI 10.15252/embj.201591481, PubMed 26041457 -
CSPP-L Associates with the Desmosome of Polarized Epithelial Cells and Is Required for Normal Spheroid Formation
PLoS One, 10 (8), e0134789
DOI 10.1371/journal.pone.0134789, PubMed 26241740 -
Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes
Mol Cancer Res, 13 (11), 1487-501
DOI 10.1158/1541-7786.MCR-15-0125, PubMed 26124443 -
Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing
Nature, 522 (7555), 231-5
DOI 10.1038/nature14408, PubMed 26040712 -
The novel HSP90 inhibitor NVP-AUY922 shows synergistic anti-leukemic activity with cytarabine in vivo
Exp Cell Res, 340 (2), 220-6
DOI 10.1016/j.yexcr.2015.12.017, PubMed 26748184 -
Cellular functions of Rab GTPases at a glance
J Cell Sci, 128 (17), 3171-6
DOI 10.1242/jcs.166074, PubMed 26272922 -
Functional specialization of chordate CDK1 paralogs during oogenic meiosis
Cell Cycle, 14 (6), 880-93
DOI 10.1080/15384101.2015.1006000, PubMed 25714331
Publications 2014
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Trans-splicing and operons in metazoans: translational control in maternally regulated development and recovery from growth arrest
Mol Biol Evol, 32 (3), 585-99
DOI 10.1093/molbev/msu336, PubMed 25525214 -
Investigating spermatogenesis in Drosophila melanogaster
Methods, 68 (1), 218-27
DOI 10.1016/j.ymeth.2014.04.020, PubMed 24798812 -
Photoactivation approaches reveal a role for Rab11 in FGFR4 recycling and signalling
Traffic, 15 (6), 665-83
DOI 10.1111/tra.12168, PubMed 24589086 -
PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1
Biochem J, 461 (3), 383-90
DOI 10.1042/BJ20140132, PubMed 24840251 -
Promyelocytic leukemia bodies tether to early endosomes during mitosis
Cell Cycle, 13 (11), 1749-55
DOI 10.4161/cc.28653, PubMed 24675887 -
The ether lipid precursor hexadecylglycerol stimulates the release and changes the composition of exosomes derived from PC-3 cells
J Biol Chem, 290 (7), 4225-37
DOI 10.1074/jbc.M114.593962, PubMed 25519911 -
An ER clamp for endosome fission
EMBO J, 34 (2), 136-7
DOI 10.15252/embj.201490707, PubMed 25502456 -
Regulation of the Tumor-Suppressor Function of the Class III Phosphatidylinositol 3-Kinase Complex by Ubiquitin and SUMO
Cancers (Basel), 7 (1), 1-29
DOI 10.3390/cancers7010001, PubMed 25545884 -
Association of CHMP4B and autophagy with micronuclei: implications for cataract formation
Biomed Res Int, 2014, 974393
DOI 10.1155/2014/974393, PubMed 24741567 -
CK2 involvement in ESCRT-III complex phosphorylation
Arch Biochem Biophys, 545, 83-91
DOI 10.1016/j.abb.2014.01.006, PubMed 24440309 -
Nucleolin regulates phosphorylation and nuclear export of fibroblast growth factor 1 (FGF1)
PLoS One, 9 (3), e90687
DOI 10.1371/journal.pone.0090687, PubMed 24595027 -
Ribosomal readthrough at a short UGA stop codon context triggers dual localization of metabolic enzymes in Fungi and animals
PLoS Genet, 10 (10), e1004685
DOI 10.1371/journal.pgen.1004685, PubMed 25340584 -
ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4
Nat Cell Biol, 16 (6), 550-60
DOI 10.1038/ncb2959, PubMed 24814515 -
Monitoring phosphatidylinositol 3-phosphate in multivesicular endosome biogenesis
Methods Enzymol, 534, 3-23
DOI 10.1016/B978-0-12-397926-1.00001-9, PubMed 24359945
Publications 2013
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Myotubularin and PtdIns3P remodel the sarcoplasmic reticulum in muscle in vivo
J Cell Sci, 126 (Pt 8), 1806-19
DOI 10.1242/jcs.118505, PubMed 23444364 -
Photochemical internalization (PCI) of immunotoxins targeting CD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties
J Control Release, 168 (3), 317-26
DOI 10.1016/j.jconrel.2013.03.023, PubMed 23567040 -
Spatiotemporal control of Cindr at ring canals during incomplete cytokinesis in the Drosophila male germline
Dev Biol, 377 (1), 9-20
DOI 10.1016/j.ydbio.2013.02.021, PubMed 23499247 -
Phosphatidylinositol 5-phosphate is a second messenger important for cell migration
Commun Integr Biol, 6 (5), e25446
DOI 10.4161/cib.25446, PubMed 24265857 -
Molecular mechanisms of the membrane sculpting ESCRT pathway
Cold Spring Harb Perspect Biol, 5 (9)
DOI 10.1101/cshperspect.a016766, PubMed 24003212 -
TRAF6 mediates ubiquitination of KIF23/MKLP1 and is required for midbody ring degradation by selective autophagy
Autophagy, 9 (12), 1955-64
DOI 10.4161/auto.26085, PubMed 24128730 -
Membrane remodeling by the PX-BAR protein SNX18 promotes autophagosome formation
J Cell Biol, 202 (2), 331-49
DOI 10.1083/jcb.201205129, PubMed 23878278 -
Basic presynaptic functions in hippocampal neurons are not affected by acute or chronic lithium treatment
J Neural Transm (Vienna), 121 (2), 211-9
DOI 10.1007/s00702-013-1087-9, PubMed 24036894 -
RSK2 regulates endocytosis of FGF receptor 1 by phosphorylation on serine 789
Oncogene, 33 (40), 4823-36
DOI 10.1038/onc.2013.425, PubMed 24141780 -
Phosphoinositide 3-kinases as accelerators and brakes of autophagy
FEBS J, 280 (24), 6322-37
DOI 10.1111/febs.12486, PubMed 23953235 -
Two-tiered control of epithelial growth and autophagy by the insulin receptor and the ret-like receptor, stitcher
PLoS Biol, 11 (7), e1001612
DOI 10.1371/journal.pbio.1001612, PubMed 23935447 -
Class III phosphatidylinositol 3-kinase and its catalytic product PtdIns3P in regulation of endocytic membrane traffic
FEBS J, 280 (12), 2730-42
DOI 10.1111/febs.12116, PubMed 23289851 -
Phosphatidylinositol 3-phosphate, a lipid that regulates membrane dynamics, protein sorting and cell signalling
Bioessays, 35 (10), 900-12
DOI 10.1002/bies.201300064, PubMed 23881848 -
Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation
PLoS One, 8 (7), e68072
DOI 10.1371/journal.pone.0068072, PubMed 23840886 -
Lamin A/C cleavage by caspase-6 activation is crucial for apoptotic induction by photodynamic therapy with hexaminolevulinate in human B-cell lymphoma cells
Cancer Lett, 339 (1), 25-32
DOI 10.1016/j.canlet.2013.07.026, PubMed 23916608 -
The use of femto-second lasers to trigger powerful explosions of gold nanorods to destroy cancer cells
Biomaterials, 34 (26), 6157-62
DOI 10.1016/j.biomaterials.2013.04.048, PubMed 23706782 -
ERK-mediated phosphorylation of fibroblast growth factor receptor 1 on Ser777 inhibits signaling
Sci Signal, 6 (262), ra11
DOI 10.1126/scisignal.2003087, PubMed 23405013
Publications 2012
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Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression
FEBS Lett, 586 (11), 1584-91
DOI 10.1016/j.febslet.2012.04.046, PubMed 22673570 -
OikoBase: a genomics and developmental transcriptomics resource for the urochordate Oikopleura dioica
Nucleic Acids Res, 41 (Database issue), D845-53
DOI 10.1093/nar/gks1159, PubMed 23185044 -
Profiling of microRNAs in exosomes released from PC-3 prostate cancer cells
Biochim Biophys Acta, 1819 (11-12), 1154-63
DOI 10.1016/j.bbagrm.2012.08.016, PubMed 22982408 -
Cullin-3 regulates late endosome maturation
Proc Natl Acad Sci U S A, 109 (3), 823-8
DOI 10.1073/pnas.1118744109, PubMed 22219362 -
Guidelines for the use and interpretation of assays for monitoring autophagy
Autophagy, 8 (4), 445-544
DOI 10.4161/auto.19496, PubMed 22966490 -
Antibody crossreactivity between the tumour suppressor PHLPP1 and the proto-oncogene β-catenin
EMBO Rep, 14 (1), 10-1
DOI 10.1038/embor.2012.188, PubMed 23229585 -
The ESCRT machinery mediates polarization of fibroblasts through regulation of myosin light chain
J Cell Sci, 125 (Pt 1), 29-36
DOI 10.1242/jcs.088310, PubMed 22266905 -
Selective autophagy in Drosophila
Int J Cell Biol, 2012, 146767
DOI 10.1155/2012/146767, PubMed 22567011 -
p62 at the interface of autophagy, oxidative stress signaling, and cancer
Antioxid Redox Signal, 17 (5), 786-93
DOI 10.1089/ars.2011.4394, PubMed 22074114 -
Effect of cycloheximide on epidermal growth factor receptor trafficking and signaling
FEBS Lett, 586 (20), 3575-81
DOI 10.1016/j.febslet.2012.08.022, PubMed 22971756 -
Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration
EMBO Rep, 14 (1), 57-64
DOI 10.1038/embor.2012.183, PubMed 23154468 -
The PtdIns3P-binding protein Phafin 2 mediates epidermal growth factor receptor degradation by promoting endosome fusion
Traffic, 13 (11), 1547-63
DOI 10.1111/j.1600-0854.2012.01400.x, PubMed 22816767 -
Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1
Biochem J, 441 (1), 399-406
DOI 10.1042/BJ20111424, PubMed 21936852 -
The oncoprotein ErbB3 is endocytosed in the absence of added ligand in a clathrin-dependent manner
Carcinogenesis, 33 (5), 1031-9
DOI 10.1093/carcin/bgs128, PubMed 22436610 -
FGF1-gold nanoparticle conjugates targeting FGFR efficiently decrease cell viability upon NIR irradiation
Int J Nanomedicine, 7, 5915-27
DOI 10.2147/IJN.S36575, PubMed 23226697 -
A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice
Cancer Res, 72 (11), 2822-32
DOI 10.1158/0008-5472.CAN-11-3336, PubMed 22440753 -
Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnα1 and Kpnβ1
Traffic, 13 (5), 650-64
DOI 10.1111/j.1600-0854.2012.01341.x, PubMed 22321063
Publications 2011
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Cell biology. Growth signaling from inside
Science, 334 (6056), 611-2
DOI 10.1126/science.1214355, PubMed 22053037 -
p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects
Autophagy, 7 (6), 572-83
DOI 10.4161/auto.7.6.14943, PubMed 21325881 -
Septation of infectious hyphae is critical for appressoria formation and virulence in the smut fungus Ustilago maydis
PLoS Pathog, 7 (5), e1002044
DOI 10.1371/journal.ppat.1002044, PubMed 21625538 -
The AAA-type ATPases Pex1p and Pex6p and their role in peroxisomal matrix protein import in Saccharomyces cerevisiae
Biochim Biophys Acta, 1823 (1), 150-8
DOI 10.1016/j.bbamcr.2011.09.005, PubMed 21963882 -
The phosphoinositide 3-kinase Vps34p is required for pexophagy in Saccharomyces cerevisiae
Biochem J, 434 (1), 161-70
DOI 10.1042/BJ20101115, PubMed 21121900 -
Structure and functions of stable intercellular bridges formed by incomplete cytokinesis during development
Commun Integr Biol, 4 (1), 1-9
DOI 10.4161/cib.4.1.13550, PubMed 21509167 -
Clathrin- and dynamin-independent endocytosis of FGFR3--implications for signalling
PLoS One, 6 (7), e21708
DOI 10.1371/journal.pone.0021708, PubMed 21779335 -
Generation of human adult mesenchymal stromal/stem cells expressing defined xenogenic vascular endothelial growth factor levels by optimized transduction and flow cytometry purification
Tissue Eng Part C Methods, 18 (4), 283-92
DOI 10.1089/ten.TEC.2011.0413, PubMed 22070632 -
Molecular mechanisms of ubiquitin-dependent membrane traffic
Annu Rev Biophys, 40, 119-42
DOI 10.1146/annurev-biophys-042910-155404, PubMed 21332354 -
The driver of malignancy in KG-1a leukemic cells, FGFR1OP2-FGFR1, encodes an HSP90 addicted oncoprotein
Cell Signal, 23 (11), 1758-66
DOI 10.1016/j.cellsig.2011.06.010, PubMed 21745565 -
SPG20, a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesis
Oncogene, 30 (37), 3967-78
DOI 10.1038/onc.2011.109, PubMed 21499309 -
Cell polarity and migration: emerging role for the endosomal sorting machinery
Physiology (Bethesda), 26 (3), 171-80
DOI 10.1152/physiol.00054.2010, PubMed 21670163 -
Cargo-dependent degradation of ESCRT-I as a feedback mechanism to modulate endosomal sorting
Traffic, 12 (9), 1211-26
DOI 10.1111/j.1600-0854.2011.01220.x, PubMed 21564451 -
Basic and discovery-based translational research on cancer was on the agenda at the 21st Congress of the European Association for Cancer Research (EACR) in Oslo, Norway, 26-29 June 2010
Clin. Transl. Oncol., 13 (1), 1-2
DOI 10.1007/s12094-011-0608-y -
Histone variant innovation in a rapidly evolving chordate lineage
BMC Evol Biol, 11, 208
DOI 10.1186/1471-2148-11-208, PubMed 21756361 -
Endocytosis and signaling
Curr Opin Cell Biol, 23 (4), 393-403
DOI 10.1016/j.ceb.2011.03.008, PubMed 21474295 -
Cell biology. A helix for the final cut
Science, 331 (6024), 1533-4
DOI 10.1126/science.1204208, PubMed 21436431 -
Shaping development with ESCRTs
Nat Cell Biol, 14 (1), 38-45
DOI 10.1038/ncb2381, PubMed 22193162 -
CIN85 regulates ubiquitination and degradative endosomal sorting of the EGF receptor
Exp Cell Res, 317 (13), 1804-16
DOI 10.1016/j.yexcr.2011.05.016, PubMed 21635887 -
A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis
PLoS One, 6 (3), e17086
DOI 10.1371/journal.pone.0017086, PubMed 21455500 -
Cell differentiation: midbody remnants - junk or fate factors?
Curr Biol, 21 (23), R958-60
DOI 10.1016/j.cub.2011.10.035, PubMed 22153165 -
Simultaneously targeting mitochondria and endoplasmic reticulum by photodynamic therapy induces apoptosis in human lymphoma cells
Photochem Photobiol Sci, 10 (11), 1773-82
DOI 10.1039/c1pp05169e, PubMed 21881674 -
Connexin43 acts as a colorectal cancer tumor suppressor and predicts disease outcome
Int J Cancer, 131 (3), 570-81
DOI 10.1002/ijc.26392, PubMed 21866551 -
Harald Stenmark: hands on FYVE-fingers. Interview by Caitlin Sedwick
J Cell Biol, 192 (4), 544-5
DOI 10.1083/jcb.1924pi, PubMed 21339328 -
Ligand-induced downregulation of TrkA is partly regulated through ubiquitination by Cbl
FEBS Lett, 585 (12), 1741-7
DOI 10.1016/j.febslet.2011.04.056, PubMed 21570973 -
cAMP induces autophagy via a novel pathway involving ERK, cyclin E and Beclin 1
Autophagy, 7 (10), 1199-211
DOI 10.4161/auto.7.10.16649, PubMed 21750416 -
Splenic marginal zone lymphoma with VH1-02 gene rearrangement expresses poly- and self-reactive antibodies with similar reactivity
Blood, 118 (12), 3331-9
DOI 10.1182/blood-2011-03-341651, PubMed 21725051 -
ESCRT proteins and cell signalling
Traffic, 12 (10), 1291-7
DOI 10.1111/j.1600-0854.2011.01210.x, PubMed 21518165 -
Fibroblast growth factors and their receptors in cancer
Biochem J, 437 (2), 199-213
DOI 10.1042/BJ20101603, PubMed 21711248 -
Translocation of exogenous FGF1 into cytosol and nucleus is a periodic event independent of receptor kinase activity
Exp Cell Res, 317 (7), 1005-15
DOI 10.1016/j.yexcr.2011.01.003, PubMed 21223966
Publications 2010
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Protein secretion: unconventional exit by exophagy
Curr Biol, 20 (9), R415-8
DOI 10.1016/j.cub.2010.03.011, PubMed 20462486 -
p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy
Autophagy, 6 (3), 330-44
DOI 10.4161/auto.6.3.11226, PubMed 20168092 -
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy
Mol Cell, 38 (2), 265-79
DOI 10.1016/j.molcel.2010.04.007, PubMed 20417604 -
An inhibitory role of the G-protein regulator AGS3 in mTOR-dependent macroautophagy
PLoS One, 5 (1), e8877
DOI 10.1371/journal.pone.0008877, PubMed 20126274 -
Cindr interacts with anillin to control cytokinesis in Drosophila melanogaster
Curr Biol, 20 (10), 944-50
DOI 10.1016/j.cub.2010.03.068, PubMed 20451383 -
Intracellular Mycobacterium avium intersect transferrin in the Rab11(+) recycling endocytic pathway and avoid lipocalin 2 trafficking to the lysosomal pathway
J Infect Dis, 201 (5), 783-92
DOI 10.1086/650493, PubMed 20121435 -
Roles of fibroblast growth factor receptors in carcinogenesis
Mol Cancer Res, 8 (11), 1439-52
DOI 10.1158/1541-7786.MCR-10-0168, PubMed 21047773 -
The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes
Immunity, 33 (4), 583-96
DOI 10.1016/j.immuni.2010.09.010, PubMed 20933442 -
UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy
Autophagy, 6 (7), 863-70
DOI 10.4161/auto.6.7.13033, PubMed 20724836 -
Ubiquitination of alpha 5 beta 1 integrin controls fibroblast migration through lysosomal degradation of fibronectin-integrin complexes
Dev Cell, 19 (1), 148-59
DOI 10.1016/j.devcel.2010.06.010, PubMed 20643357 -
Ubiquitination of α-integrin cytoplasmic tails
Commun Integr Biol, 3 (6), 583-5
DOI 10.4161/cib.3.6.13176, PubMed 21331246 -
Autophagy and its physiological relevance in arthropods: current knowledge and perspectives
Autophagy, 6 (5), 575-88
DOI 10.4161/auto.6.5.11962, PubMed 20458176 -
Divide and ProsPer: the emerging role of PtdIns3P in cytokinesis
Trends Cell Biol, 20 (11), 642-9
DOI 10.1016/j.tcb.2010.08.010, PubMed 20880709 -
Autophagy as a trigger for cell death Autophagic degradation of inhibitor of apoptosis dBruce controls DNA fragmentation during late oogenesis in Drosophila
Autophagy, 6 (8), 1214-+
DOI 10.4161/auto.6.8.13694 -
Autophagy as a trigger for cell death: autophagic degradation of inhibitor of apoptosis dBruce controls DNA fragmentation during late oogenesis in Drosophila
Autophagy, 6 (8), 1214-5
DOI 10.4161/auto.6.8.13694, PubMed 20935512 -
Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis
J Cell Biol, 190 (4), 523-31
DOI 10.1083/jcb.201002035, PubMed 20713604 -
FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport
J Cell Biol, 188 (2), 253-69
DOI 10.1083/jcb.200907015, PubMed 20100911 -
ESCRT & Co
Biol Cell, 102 (5), 293-318
DOI 10.1042/BC20090161, PubMed 20222872 -
p62, an autophagy hero or culprit?
Nat Cell Biol, 12 (3), 207-9
DOI 10.1038/ncb0310-207, PubMed 20190829 -
PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody
Nat Cell Biol, 12 (4), 362-71
DOI 10.1038/ncb2036, PubMed 20208530 -
Cytokinesis and cancer (vol 584, pg 2652, 2010)
FEBS Lett., 584 (18), 4128
DOI 10.1016/j.febslet.2010.08.016 -
Cytokinesis and cancer
FEBS Lett, 584 (12), 2652-61
DOI 10.1016/j.febslet.2010.03.044, PubMed 20371245 -
CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice
EMBO J, 29 (14), 2421-32
DOI 10.1038/emboj.2010.120, PubMed 20551902 -
Time-resolved ultrastructural detection of phosphatidylinositol 3-phosphate
J Histochem Cytochem, 58 (11), 1025-32
DOI 10.1369/jhc.2010.955815, PubMed 20713985 -
Activation of the ustilagic acid biosynthesis gene cluster in Ustilago maydis by the C2H2 zinc finger transcription factor Rua1
Appl Environ Microbiol, 76 (8), 2633-40
DOI 10.1128/AEM.02211-09, PubMed 20173069 -
A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic
Exp Cell Res, 316 (20), 3368-78
DOI 10.1016/j.yexcr.2010.07.008, PubMed 20643123
Publications 2009
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Monitoring autophagic degradation of p62/SQSTM1
Methods Enzymol, 452, 181-97
DOI 10.1016/S0076-6879(08)03612-4, PubMed 19200883 -
Autophagy in tumour suppression and promotion
Mol Oncol, 3 (4), 366-75
DOI 10.1016/j.molonc.2009.05.007, PubMed 19559660 -
Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101
J Cell Sci, 122 (Pt 21), 3883-93
DOI 10.1242/jcs.053801, PubMed 19808888 -
ESCRTing membrane deformation
Cell, 136 (1), 15-7
DOI 10.1016/j.cell.2008.12.029, PubMed 19135881 -
Cell death during Drosophila melanogaster early oogenesis is mediated through autophagy
Autophagy, 5 (3), 298-302
DOI 10.4161/auto.5.3.7454, PubMed 19066465 -
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins
Nature, 458 (7237), 445-52
DOI 10.1038/nature07961, PubMed 19325624 -
Disruption of Vps4 and JNK function in Drosophila causes tumour growth
PLoS One, 4 (2), e4354
DOI 10.1371/journal.pone.0004354, PubMed 19194501 -
The role of ESCRT proteins in attenuation of cell signalling
Biochem Soc Trans, 37 (Pt 1), 137-42
DOI 10.1042/BST0370137, PubMed 19143618 -
Dual degradation mechanisms ensure disposal of NHE6 mutant protein associated with neurological disease
Exp Cell Res, 315 (17), 3014-27
DOI 10.1016/j.yexcr.2009.07.012, PubMed 19619532 -
How do ESCRT proteins control autophagy?
J Cell Sci, 122 (Pt 13), 2179-83
DOI 10.1242/jcs.050021, PubMed 19535733 -
SNX4 in complex with clathrin and dynein: implications for endosome movement
PLoS One, 4 (6), e5935
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Rab GTPases as coordinators of vesicle traffic
Nat Rev Mol Cell Biol, 10 (8), 513-25
DOI 10.1038/nrm2728, PubMed 19603039 -
Seeing is believing
Nat Rev Mol Cell Biol, 10 (9), 582
DOI 10.1038/nrm2747, PubMed 19702012 -
Multivesicular endosome biogenesis in the absence of ESCRTs
Traffic, 10 (7), 925-37
DOI 10.1111/j.1600-0854.2009.00920.x, PubMed 19490536 -
Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants
J Cell Sci, 122 (Pt 14), 2413-23
DOI 10.1242/jcs.046391, PubMed 19571114 -
Ultrastructural characterization of giant endosomes induced by GTPase-deficient Rab5
Histochem Cell Biol, 133 (1), 41-55
DOI 10.1007/s00418-009-0643-8, PubMed 19830447 -
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin
J Biol Chem, 284 (37), 25388-403
DOI 10.1074/jbc.M109.001289, PubMed 19574212 -
Size limitation in translocation of fibroblast growth factor 1 fusion proteins across the endosomal membrane
Biochemistry, 48 (30), 7209-18
DOI 10.1021/bi9007353, PubMed 19558187 -
The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway
J Immunol, 183 (9), 5909-16
DOI 10.4049/jimmunol.0900441, PubMed 19812211
Publications 2008
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Cell-cycle-dependent binding kinetics for the early endosomal tethering factor EEA1
EMBO Rep, 9 (2), 171-8
DOI 10.1038/sj.embor.7401152, PubMed 18188183 -
Quantitative analysis of autophagic activity in Drosophila neural tissues by measuring the turnover rates of pathway substrates
Methods Enzymol, 451, 639-51
DOI 10.1016/S0076-6879(08)03235-7, PubMed 19185743 -
SLC9A6 mutations cause X-linked mental retardation, microcephaly, epilepsy, and ataxia, a phenotype mimicking Angelman syndrome
Am J Hum Genet, 82 (4), 1003-10
DOI 10.1016/j.ajhg.2008.01.013, PubMed 18342287 -
PKCbetaII modulates translation independently from mTOR and through RACK1
Biochem J, 415 (1), 77-85
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Eukaryotic ribosomes host PKC activity
Biochem Biophys Res Commun, 376 (1), 65-9
DOI 10.1016/j.bbrc.2008.08.118, PubMed 18768137 -
Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis
Mol Biol Cell, 19 (8), 3390-403
DOI 10.1091/mbc.e07-12-1219, PubMed 18480409 -
The PI 3-kinase regulator Vps15 is required for autophagic clearance of protein aggregates
Autophagy, 4 (4), 500-6
DOI 10.4161/auto.5829, PubMed 18326940 -
Mechanisms and functions of endocytosis
J Cell Biol, 180 (1), 7-11
DOI 10.1083/jcb.200711073, PubMed 18195098 -
Regulation of early endosomal entry by the Drosophila tumor suppressors Rabenosyn and Vps45
Mol Biol Cell, 19 (10), 4167-76
DOI 10.1091/mbc.e08-07-0716, PubMed 18685079 -
Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain
J Cell Biol, 180 (6), 1065-71
DOI 10.1083/jcb.200711108, PubMed 18347073 -
Membranes and organelles
Curr Opin Cell Biol, 20 (4), 357-9
DOI 10.1016/j.ceb.2008.06.005, PubMed 18588977 -
ESCRTing autophagic clearance of aggregating proteins
Autophagy, 4 (2), 233-236
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ESCRT functions in autophagy and associated disease
Cell Cycle, 7 (9), 1166-72
DOI 10.4161/cc.7.9.5784, PubMed 18418046 -
ESCRT proteins in physiology and disease
Exp Cell Res, 315 (9), 1619-26
DOI 10.1016/j.yexcr.2008.10.013, PubMed 19013455 -
Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus
Mol Cell Biol, 28 (12), 4129-41
DOI 10.1128/MCB.02117-07, PubMed 18411303 -
Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation
Mol Biol Cell, 19 (8), 3454-62
DOI 10.1091/mbc.e07-10-0988, PubMed 18508924 -
FGF-1: from biology through engineering to potential medical applications
Crit Rev Clin Lab Sci, 45 (1), 91-135
DOI 10.1080/10408360701713120, PubMed 18293181
Publications 2007
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Fibroblast growth factor receptor-induced phosphorylation of STAT1 at the Golgi apparatus without translocation to the nucleus
J Cell Physiol, 212 (1), 148-56
DOI 10.1002/jcp.21014, PubMed 17311277 -
Endocytosis of the dermatan sulfate proteoglycan decorin utilizes multiple pathways and is modulated by epidermal growth factor receptor signaling
Biochimie, 89 (5), 637-57
DOI 10.1016/j.biochi.2006.12.012, PubMed 17335953 -
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease
J Cell Biol, 179 (3), 485-500
DOI 10.1083/jcb.200702115, PubMed 17984323 -
Aberrant receptor signaling and trafficking as mechanisms in oncogenesis
Crit Rev Oncog, 13 (1), 39-74
DOI 10.1615/critrevoncog.v13.i1.20, PubMed 17956217 -
Origin and evolution of self-consumption: autophagy
Adv Exp Med Biol, 607, 111-8
DOI 10.1007/978-0-387-74021-8_9, PubMed 17977463 -
Structural requirements for furin-induced cleavage and activation of Shiga toxin
Biochem Biophys Res Commun, 357 (1), 144-9
DOI 10.1016/j.bbrc.2007.03.110, PubMed 17407762 -
ESCRTs
Curr Biol, 17 (2), R42-3
DOI 10.1016/j.cub.2006.12.009, PubMed 17240322 -
Vps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradation
Traffic, 8 (11), 1617-29
DOI 10.1111/j.1600-0854.2007.00630.x, PubMed 17714434 -
A nuclear export sequence located on a beta-strand in fibroblast growth factor-1
J Biol Chem, 282 (36), 26245-56
DOI 10.1074/jbc.M611234200, PubMed 17616529 -
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
J Biol Chem, 282 (33), 24131-45
DOI 10.1074/jbc.M702824200, PubMed 17580304 -
RILP is required for the proper morphology and function of late endosomes
J Cell Sci, 120 (Pt 21), 3729-37
DOI 10.1242/jcs.017301, PubMed 17959629 -
Differential functions of Hrs and ESCRT proteins in endocytic membrane trafficking
Exp Cell Res, 314 (4), 801-13
DOI 10.1016/j.yexcr.2007.10.014, PubMed 18031739 -
Developmental biology: moonlighting at the pole
Nature, 445 (7127), 497-9
DOI 10.1038/445497a, PubMed 17268460 -
ESCRTs and Fab1 regulate distinct steps of autophagy
Curr Biol, 17 (20), 1817-25
DOI 10.1016/j.cub.2007.09.032, PubMed 17935992 -
Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
Autophagy, 4 (2), 176-84
DOI 10.4161/auto.5269, PubMed 18059160 -
Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles
Genetics, 176 (2), 1283-97
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Stimulating the cell's appetite for itself
Nat Chem Biol, 3 (6), 304-6
DOI 10.1038/nchembio0607-304, PubMed 17510644 -
Indirubin-3'-monoxime inhibits autophosphorylation of FGFR1 and stimulates ERK1/2 activity via p38 MAPK
Oncogene, 26 (44), 6372-85
DOI 10.1038/sj.onc.1210473, PubMed 17533378
Publications 2006
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The function of ubiquitin-binding protein complexes in endocytic downregulation of growth factor receptors
Crit Rev Oncog, 12 (3-4), 301; discussion 301-2
DOI 10.1615/critrevoncog.v12.i3-4.90, PubMed 17425510 -
The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor
Mol Biol Cell, 17 (6), 2513-23
DOI 10.1091/mbc.e05-10-0915, PubMed 16554368 -
Cloning and subcellular localization of a human phosphatidylinositol 3-phosphate 5-kinase, PIKfyve/Fab1
Gene, 371 (1), 34-41
DOI 10.1016/j.gene.2005.11.009, PubMed 16448788 -
Working out coupled monoubiquitination
Nat Cell Biol, 8 (11), 1218-9
DOI 10.1038/ncb1106-1218, PubMed 17077855 -
Specification of SUMO1- and SUMO2-interacting motifs
J Biol Chem, 281 (23), 16117-27
DOI 10.1074/jbc.M512757200, PubMed 16524884 -
Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting
Nat Struct Mol Biol, 13 (3), 272-7
DOI 10.1038/nsmb1051, PubMed 16462748 -
Structural basis of ubiquitin recognition by mammalian Eap45 GLUE domain
Nat Struct Mol Biol, 13 (11), 1031-2
DOI 10.1038/nsmb1163, PubMed 17057714 -
Regulation of ubiquitin-binding proteins by monoubiquitination
Nat Cell Biol, 8 (2), 163-9
DOI 10.1038/ncb1354, PubMed 16429130 -
Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity
EMBO J, 25 (4), 683-92
DOI 10.1038/sj.emboj.7600991, PubMed 16467847 -
Activation of the epidermal growth factor (EGF) receptor induces formation of EGF receptor- and Grb2-containing clathrin-coated pits
Mol Cell Biol, 26 (2), 389-401
DOI 10.1128/MCB.26.2.389-401.2006, PubMed 16382132 -
EGF-induced activation of the EGF receptor does not trigger mobilization of caveolae
Traffic, 7 (11), 1518-27
DOI 10.1111/j.1600-0854.2006.00487.x, PubMed 16984407 -
Reduced binding of FGF1 to mutant fibroblast growth factor receptor 3
Growth Factors, 24 (2), 111-9
DOI 10.1080/08977190600621388, PubMed 16801131 -
Ligand-specific dynamics of the androgen receptor at its response element in living cells
Mol Cell Biol, 27 (5), 1823-43
DOI 10.1128/MCB.01297-06, PubMed 17189428 -
Endocytic processing of connexin43 gap junctions: a morphological study
Biochem J, 393 (Pt 1), 59-67
DOI 10.1042/BJ20050674, PubMed 16162097 -
A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body
Exp Cell Res, 312 (11), 2018-27
DOI 10.1016/j.yexcr.2006.03.002, PubMed 16600212 -
Regulation of membrane traffic by phosphoinositide 3-kinases
J Cell Sci, 119 (Pt 4), 605-14
DOI 10.1242/jcs.02855, PubMed 16467569 -
How a RING finger protein and a steroid hormone control autophagy
Autophagy, 2 (4), 321-2
DOI 10.4161/auto.3091, PubMed 16874068 -
FGF-1 as a possible carrier for targeted drug delivery
Oncol Res, 16 (1), 27-34
DOI 10.3727/000000006783981242, PubMed 16783965 -
Both clathrin-positive and -negative coats are involved in endosomal sorting of the EGF receptor
Exp Cell Res, 312 (16), 3036-48
DOI 10.1016/j.yexcr.2006.06.004, PubMed 16859684 -
Human stratum corneum lipid organization as observed by atomic force microscopy on Langmuir-Blodgett films
J Struct Biol, 158 (3), 386-400
DOI 10.1016/j.jsb.2006.12.006, PubMed 17287132 -
Hrs makes receptors silent: a key to endosomal protein sorting
Crit Rev Oncog, 12 (3-4), 295, discussion 295-6
DOI 10.1615/critrevoncog.v12.i3-4.70, PubMed 17425508 -
A new side to ubiquitin
Trends Biochem Sci, 31 (10), 541-4
DOI 10.1016/j.tibs.2006.07.009, PubMed 16901703 -
Flat clathrin coats on endosomes mediate degradative protein sorting by scaffolding Hrs in dynamic microdomains
J Cell Sci, 119 (Pt 12), 2414-24
DOI 10.1242/jcs.02978, PubMed 16720641 -
Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors
Mol Biol Cell, 17 (9), 3989-4001
DOI 10.1091/mbc.e06-03-0239, PubMed 16837550 -
Analyzing phosphoinositides and their interacting proteins
Nat Methods, 3 (4), 251-8
DOI 10.1038/nmeth867, PubMed 16554828 -
The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport
J Cell Sci, 119 (Pt 19), 3944-57
DOI 10.1242/jcs.03153, PubMed 16954148 -
CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4
EMBO J, 25 (16), 3738-49
DOI 10.1038/sj.emboj.7601267, PubMed 16888620 -
Endosomal and non-endosomal functions of ESCRT proteins
Trends Cell Biol, 16 (6), 317-26
DOI 10.1016/j.tcb.2006.04.004, PubMed 16716591 -
Functional diversity of FGF-2 isoforms by intracellular sorting
Bioessays, 28 (5), 504-14
DOI 10.1002/bies.20405, PubMed 16615083 -
Different abilities of the four FGFRs to mediate FGF-1 translocation are linked to differences in the receptor C-terminal tail
J Cell Sci, 119 (Pt 20), 4332-41
DOI 10.1242/jcs.03209, PubMed 17003104 -
FGF-1 and FGF-2 require the cytosolic chaperone Hsp90 for translocation into the cytosol and the cell nucleus
J Biol Chem, 281 (16), 11405-12
DOI 10.1074/jbc.M600477200, PubMed 16495214 -
Structural requirements of FGF-1 for receptor binding and translocation into cells
Biochemistry, 45 (51), 15338-48
DOI 10.1021/bi0618114, PubMed 17176056
Publications 2005
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p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
J Cell Biol, 171 (4), 603-14
DOI 10.1083/jcb.200507002, PubMed 16286508 -
Alix regulates cortical actin and the spatial distribution of endosomes
J Cell Sci, 118 (Pt 12), 2625-35
DOI 10.1242/jcs.02382, PubMed 15914539 -
Fluorimetric HPLC detection of endogenous riboflavin 4',5'-cyclic phosphate in rat liver at nanomolar concentrations
Anal Biochem, 341 (2), 214-9
DOI 10.1016/j.ab.2005.01.060, PubMed 15907866 -
When and from whom do female pied flycatchers (Ficedula hypoleuca) solicit copulations
Behaviour, 142, 1059-1076
DOI 10.1163/156853905774405335 -
Different intracellular trafficking of FGF1 endocytosed by the four homologous FGF receptors
J Cell Sci, 118 (Pt 17), 3869-81
DOI 10.1242/jcs.02509, PubMed 16091423 -
Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B
Cell, 121 (3), 437-50
DOI 10.1016/j.cell.2005.02.017, PubMed 15882625 -
[Ricin--a therapeutic agent and a biological weapon]
Tidsskr Nor Laegeforen, 125 (18), 2477-9
PubMed 16186864 -
Manipulation of male quality in wild tits: effects on paternity loss
Behav. Ecol., 16 (4), 747-754
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The Rab5 effector Rabaptin-5 and its isoform Rabaptin-5delta differ in their ability to interact with the small GTPase Rab4
FEBS J, 272 (1), 37-46
DOI 10.1111/j.1742-4658.2004.04387.x, PubMed 15634330 -
Herceptin-induced inhibition of ErbB2 signaling involves reduced phosphorylation of Akt but not endocytic down-regulation of ErbB2
Int J Cancer, 116 (3), 359-67
DOI 10.1002/ijc.21015, PubMed 15800944 -
Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain
J Biol Chem, 280 (20), 19600-6
DOI 10.1074/jbc.M501510200, PubMed 15755741 -
Individual fluctuating asymmetry in pied flycatchers (Ficedula hypoleuca) persists across moults, but is not heritable and not related to fitness
Evol. Ecol. Res., 7 (3), 381-406 -
Actin-based motility of endosomes is linked to the polar tip growth of root hairs
Eur J Cell Biol, 84 (6), 609-21
DOI 10.1016/j.ejcb.2004.12.029, PubMed 16032929 -
Two nuclear localization signals required for transport from the cytosol to the nucleus of externally added FGF-1 translocated into cells
Biochemistry, 44 (16), 6071-80
DOI 10.1021/bi047403m, PubMed 15835896 -
Highly stable mutants of human fibroblast growth factor-1 exhibit prolonged biological action
J Mol Biol, 352 (4), 860-75
DOI 10.1016/j.jmb.2005.07.066, PubMed 16126225
Publications 2004
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The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation
Mol Biol Cell, 15 (9), 4337-46
DOI 10.1091/mbc.e04-03-0250, PubMed 15240819 -
Defective downregulation of receptor tyrosine kinases in cancer
EMBO J, 23 (14), 2707-12
DOI 10.1038/sj.emboj.7600292, PubMed 15229652 -
Protein targeting to endosomes and phagosomes via FYVE and PX domains
Curr Top Microbiol Immunol, 282, 89-115
DOI 10.1007/978-3-642-18805-3_4, PubMed 14594215 -
The biogenesis of multivesicular endosomes
Nat Rev Mol Cell Biol, 5 (4), 317-23
DOI 10.1038/nrm1360, PubMed 15071556 -
Early learning affects social dominance: interspecifically cross-fostered tits become subdominant
Behav. Ecol., 15 (2), 262-268
DOI 10.1093/beheco/arh010 -
Trafficking and signaling pathways of nuclear localizing protein ligands and their receptors
Bioessays, 26 (9), 993-1004
DOI 10.1002/bies.20086, PubMed 15351969 -
Cloning and characterization of the genes encoding toxic lectins in mistletoe (Viscum album L)
Eur J Biochem, 271 (12), 2350-60
DOI 10.1111/j.1432-1033.2004.04153.x, PubMed 15182350 -
Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases
J Biol Chem, 279 (31), 32786-95
DOI 10.1074/jbc.M403759200, PubMed 15159412 -
Comparison of cAMP-dependent protein kinase substrate specificity in reaction with proteins and synthetic peptides
Biochim Biophys Acta, 1747 (2), 261-6
DOI 10.1016/j.bbapap.2004.11.016, PubMed 15698961 -
The history of ricin, abrin and related toxins
Toxicon, 44 (4), 361-70
DOI 10.1016/j.toxicon.2004.05.003, PubMed 15302520 -
Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway
Dev Cell, 7 (2), 179-92
DOI 10.1016/j.devcel.2004.07.005, PubMed 15296715 -
Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes
J Cell Biol, 164 (6), 923-33
DOI 10.1083/jcb.200312018, PubMed 15007060 -
Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes
J Cell Sci, 117 (Pt 18), 4239-51
DOI 10.1242/jcs.01287, PubMed 15292400 -
The structure of an endosomal protein sorter
Dev Cell, 7 (4), 457-8
DOI 10.1016/j.devcel.2004.09.007, PubMed 15469831 -
Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits
Mol Biol Cell, 15 (8), 3591-604
DOI 10.1091/mbc.e04-01-0041, PubMed 15194809 -
Deletion mutant of FGFR4 induces onion-like membrane structures in the nucleus
J Cell Sci, 117 (Pt 9), 1807-19
DOI 10.1242/jcs.01047, PubMed 15075241 -
Acquisition of Hrs, an essential component of phagosomal maturation, is impaired by mycobacteria
Mol Cell Biol, 24 (10), 4593-604
DOI 10.1128/MCB.24.10.4593-4604.2004, PubMed 15121875 -
Phosphorylation-regulated nucleocytoplasmic trafficking of internalized fibroblast growth factor-1
Mol Biol Cell, 16 (2), 794-810
DOI 10.1091/mbc.e04-05-0389, PubMed 15574884 -
Signaling, internalization, and intracellular activity of fibroblast growth factor
Curr Top Microbiol Immunol, 286, 45-79
DOI 10.1007/978-3-540-69494-6_3, PubMed 15645710 -
Design of fully active FGF-1 variants with increased stability
Protein Eng Des Sel, 17 (8), 603-11
DOI 10.1093/protein/gzh076, PubMed 15469994
Publications 2003
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Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes
J Cell Biol, 162 (3), 435-42
DOI 10.1083/jcb.200302131, PubMed 12900395 -
STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes
J Biol Chem, 278 (14), 12513-21
DOI 10.1074/jbc.M210843200, PubMed 12551915 -
IL-7 receptor is present on human microvascular endothelial cells
Immunol Lett, 86 (2), 163-8
DOI 10.1016/s0165-2478(03)00018-x, PubMed 12644318 -
Phosphatidylinositol 3-phosphate is found in microdomains of early endosomes
Histochem Cell Biol, 120 (6), 445-53
DOI 10.1007/s00418-003-0591-7, PubMed 14618335 -
Endocytosis and signaling: a relationship under development
Cell, 115 (5), 513-21
DOI 10.1016/s0092-8674(03)00932-2, PubMed 14651844 -
The cytoplasmic tail of invariant chain modulates antigen processing and presentation
Eur J Immunol, 33 (2), 277-86
DOI 10.1002/immu.200310001, PubMed 12548558 -
Thermal depolymerization of alginate in the solid state
Carbohydr. Polym., 54 (4), 431-438
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Characterization and tissue expression of acidic fibroblast growth factor binding protein homologue in Drosophila melanogaster
Gene, 310, 185-91
DOI 10.1016/s0378-1119(03)00550-x, PubMed 12801646 -
Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors
J Biol Chem, 278 (41), 39735-46
DOI 10.1074/jbc.M304541200, PubMed 12874286 -
Translocation of FGF-1 and FGF-2 across vesicular membranes occurs during G1-phase by a common mechanism
Mol Biol Cell, 15 (2), 801-14
DOI 10.1091/mbc.e03-08-0589, PubMed 14657241 -
The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4
Dev Cell, 5 (5), 709-22
DOI 10.1016/s1534-5807(03)00321-6, PubMed 14602072 -
Phosphatidylinositol-3 kinase-dependent activation of Akt does not correlate with either high mitogenicity or cell migration induced by FGF-1
Anticancer Res, 23 (5A), 4071-7
PubMed 14666721 -
Phosphoinositide 3-kinase regulates maturation of lysosomes in rat hepatocytes
Biochem J, 372 (Pt 3), 861-9
DOI 10.1042/BJ20021136, PubMed 12646047 -
Peroxisomal targeting as a tool for assaying potein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner
J Biol Chem, 279 (6), 4794-801
DOI 10.1074/jbc.M309653200, PubMed 14604990 -
Transport of exogenous growth factors and cytokines to the cytosol and to the nucleus
Physiol Rev, 83 (1), 163-82
DOI 10.1152/physrev.00021.2002, PubMed 12506129 -
PI3P signaling regulates receptor sorting but not transport in the endosomal pathway
J Cell Biol, 162 (6), 971-9
DOI 10.1083/jcb.200303018, PubMed 12975344 -
Protein sorting into multivesicular endosomes
Curr Opin Cell Biol, 15 (4), 446-55
DOI 10.1016/s0955-0674(03)00080-2, PubMed 12892785 -
Phosphorylation of insulin-like growth factor binding protein-3 by deoxyribonucleic acid-dependent protein kinase reduces ligand binding and enhances nuclear accumulation
Endocrinology, 144 (5), 1984-93
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Time resolved spectroscopic optical coherence tomography for diffusion measurements
P SOC PHOTO-OPT INS, 4956, 197-204
DOI 10.1117/12.477645
Publications 2002
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Phosphorylation of Hrs downstream of the epidermal growth factor receptor
Eur J Biochem, 269 (16), 3881-7
DOI 10.1046/j.1432-1033.2002.03046.x, PubMed 12180964 -
The carboxyl-terminal domains of IgA and IgM direct isotype-specific polymerization and interaction with the polymeric immunoglobulin receptor
J Biol Chem, 277 (45), 42755-62
DOI 10.1074/jbc.M205502200, PubMed 12213814 -
The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking
J Cell Sci, 115 (Pt 5), 899-911
DOI 10.1242/jcs.115.5.899, PubMed 11870209 -
[A short form of the heparin-binding EGF-like growth factor with a changed EGF domain]
Mol Biol (Mosk), 36 (1), 76-83
PubMed 11862716 -
A short form of the heparin-binding EGF-like growth factor with a changed EGF domain
Mol. Biol., 36 (1), 58-64
DOI 10.1023/A:1014246423243 -
Vesicle transmembrane potential is required for translocation to the cytosol of externally added FGF-1
EMBO J, 21 (17), 4480-90
DOI 10.1093/emboj/cdf472, PubMed 12198150 -
Steroid signal transduction activated at the cell membrane: from plants to animals
Acta Biochim Pol, 49 (3), 735-45
PubMed 12422243 -
Role of Rab5 in the recruitment of hVps34/p150 to the early endosome
Traffic, 3 (6), 416-27
DOI 10.1034/j.1600-0854.2002.30605.x, PubMed 12010460 -
Early endosomal regulation of Smad-dependent signaling in endothelial cells
J Biol Chem, 277 (20), 18046-52
DOI 10.1074/jbc.M107983200, PubMed 11877415 -
Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes
Nat Cell Biol, 4 (5), 394-8
DOI 10.1038/ncb791, PubMed 11988743 -
Hrs and endocytic sorting of ubiquitinated membrane proteins
Cell Struct Funct, 27 (6), 403-8
DOI 10.1247/csf.27.403, PubMed 12576633 -
Past-A, a novel proton-associated sugar transporter, regulates glucose homeostasis in the brain
J Neurosci, 22 (21), 9160-5
DOI 10.1523/JNEUROSCI.22-21-09160.2002, PubMed 12417639 -
Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity
EMBO J, 21 (15), 4058-69
DOI 10.1093/emboj/cdf402, PubMed 12145206 -
Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor
J Biol Chem, 277 (26), 23864-71
DOI 10.1074/jbc.M112193200, PubMed 11964394 -
The phosphatidylinositol 3-phosphate-binding FYVE finger
FEBS Lett, 513 (1), 77-84
DOI 10.1016/s0014-5793(01)03308-7, PubMed 11911884 -
Expression of human protein tyrosine phosphatase epsilon in leucocytes: a potential ERK pathway-regulating phosphatase
Scand J Immunol, 56 (2), 195-203
DOI 10.1046/j.1365-3083.2002.01126.x, PubMed 12121439 -
Retrograde transport of ricin
Int J Med Microbiol, 291 (6-7), 517-21
DOI 10.1078/1438-4221-00161, PubMed 11890552
Publications 2001
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Modulation of intracellular transport of acidic fibroblast growth factor by mutations in the cytoplasmic receptor domain
J Cell Sci, 114 (Pt 9), 1677-89
DOI 10.1242/jcs.114.9.1677, PubMed 11398757 -
Ability of the Tat basic domain and VP22 to mediate cell binding, but not membrane translocation of the diphtheria toxin A-fragment
Biochemistry, 40 (14), 4349-58
DOI 10.1021/bi002443l, PubMed 11284691 -
Cellular functions of phosphatidylinositol 3-phosphate and FYVE domain proteins
Biochem J, 355 (Pt 2), 249-58
DOI 10.1042/0264-6021:3550249, PubMed 11284710 -
Phosphoinositides and phagocytosis
J Cell Biol, 155 (1), 15-7
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Cell biology. A lipid oils the endocytosis machine
Science, 291 (5506), 993-4
DOI 10.1126/science.291.5506.993, PubMed 11232585 -
Trafficking of phosphatidylinositol 3-phosphate from the trans-Golgi network to the lumen of the central vacuole in plant cells
Plant Cell, 13 (2), 287-301
DOI 10.1105/tpc.13.2.287, PubMed 11226186 -
Fluid phase endocytosis of [125I]iodixanol in rat liver parenchymal, endothelial and Kupffer cells
Cell Tissue Res, 304 (2), 221-30
DOI 10.1007/s004410100348, PubMed 11396716 -
Wortmannin-sensitive trafficking steps in the endocytic pathway in rat liver endothelial cells
Biochem J, 357 (Pt 2), 497-503
DOI 10.1042/0264-6021:3570497, PubMed 11439100 -
Two farms of the heparin-binding EGF-like growth factor precursor, a receptor for diphtheria toxin
Mol. Biol., 35 (1), 122-129
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[Two forms of precursors of a heparin-binding EGF-like growth factor-diphtheria toxin receptor]
Mol Biol (Mosk), 35 (1), 136-45
PubMed 11234372 -
Evading apoptosis by calcitriol-differentiated human leukemic HL-60 cells is not mediated by changes in CD95 receptor system but by increased sensitivity of these cells to insulin
Exp Cell Res, 270 (1), 119-27
DOI 10.1006/excr.2001.5335, PubMed 11597134 -
Effects of inhibitors of the vacuolar proton pump on hepatic heterophagy and autophagy
Biochim Biophys Acta, 1510 (1-2), 243-57
DOI 10.1016/s0005-2736(00)00354-0, PubMed 11342162 -
Ricin
Toxicon, 39 (11), 1723-8
DOI 10.1016/s0041-0101(01)00158-1, PubMed 11595634 -
Microbiology. Fighting anthrax with a mutant toxin
Science, 292 (5517), 647-8
DOI 10.1126/science.1060857, PubMed 11330322 -
A PtdIns(3)P-specific probe cycles on and off host cell membranes during Salmonella invasion of mammalian cells
Curr Biol, 11 (20), 1636-42
DOI 10.1016/s0960-9822(01)00486-9, PubMed 11676927 -
Hrs recruits clathrin to early endosomes
EMBO J, 20 (17), 5008-21
DOI 10.1093/emboj/20.17.5008, PubMed 11532964 -
Function of Hrs in endocytic trafficking and signalling
Biochem Soc Trans, 29 (Pt 4), 472-5
DOI 10.1042/bst0290472, PubMed 11498011 -
FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes
J Cell Sci, 114 (Pt 12), 2255-63
DOI 10.1242/jcs.114.12.2255, PubMed 11493665 -
PX domains: attracted by phosphoinositides
Nat Cell Biol, 3 (8), E179-82
DOI 10.1038/35087112, PubMed 11483972 -
The role of phosphoinositides in membrane transport
Curr Opin Cell Biol, 13 (4), 485-92
DOI 10.1016/s0955-0674(00)00240-4, PubMed 11454456 -
DNA binding-independent transcriptional activation by the androgen receptor through triggering of coactivators
J Biol Chem, 276 (33), 31030-6
DOI 10.1074/jbc.M104310200, PubMed 11429409 -
Introduction. Trafficking of lipids
Semin Cell Dev Biol, 12 (2), 135-7
DOI 10.1006/scdb.2000.0230, PubMed 11292379 -
Intracellular trafficking and turnover of phosphatidylinositol 3-phosphate
Semin Cell Dev Biol, 12 (2), 193-9
DOI 10.1006/scdb.2000.0236, PubMed 11292385 -
The Rab GTPase family
Genome Biol, 2 (5), REVIEWS3007
DOI 10.1186/gb-2001-2-5-reviews3007, PubMed 11387043 -
The Rab GTPase family
Genome Biol., 2 (5), 3007.1
Publications 2000
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An interaction between ricin and calreticulin that may have implications for toxin trafficking
J Biol Chem, 276 (10), 7202-8
DOI 10.1074/jbc.M009499200, PubMed 11113144 -
Rab5 regulates the kiss and run fusion between phagosomes and endosomes and the acquisition of phagosome leishmanicidal properties in RAW 264.7 macrophages
J Cell Sci, 113 Pt 19, 3531-41
DOI 10.1242/jcs.113.19.3531, PubMed 10984443 -
Initial events in infectious salmon anemia virus infection: evidence for the requirement of a low-pH step
J Virol, 74 (1), 218-27
DOI 10.1128/jvi.74.1.218-227.2000, PubMed 10590109 -
Requirement for prolonged action in the cytosol for optimal protein synthesis inhibition by diphtheria toxin
J Biol Chem, 275 (6), 4363-8
DOI 10.1074/jbc.275.6.4363, PubMed 10660606 -
Ultrastructural characterization of the delimiting membranes of isolated autophagosomes and amphisomes by freeze-fracture electron microscopy
Eur J Cell Biol, 79 (12), 871-82
DOI 10.1078/0171-9335-00125, PubMed 11152279 -
Autophagosome-associated variant isoforms of cytosolic enzymes
Biochem J, 352 Pt 3 (Pt 3), 773-81
DOI 10.1042/0264-6021:3520773, PubMed 11104685 -
Interaction of the EEA1 FYVE finger with phosphatidylinositol 3-phosphate and early endosomes. Role of conserved residues
J Biol Chem, 275 (32), 24595-600
DOI 10.1074/jbc.M906554199, PubMed 10807926 -
Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells
EMBO J, 19 (17), 4577-88
DOI 10.1093/emboj/19.17.4577, PubMed 10970851 -
Requirement for C-terminal end of fibroblast growth factor receptor 4 in translocation of acidic fibroblast growth factor to cytosol and nucleus
J Cell Sci, 113 ( Pt 10), 1827-38
DOI 10.1242/jcs.113.10.1827, PubMed 10769213 -
Requirement of phosphatidylinositol 3-kinase activity for translocation of exogenous aFGF to the cytosol and nucleus
J Biol Chem, 275 (16), 11972-80
DOI 10.1074/jbc.275.16.11972, PubMed 10766827 -
Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein
Biochem J, 352 Pt 3 (Pt 3), 629-35
DOI 10.1042/0264-6021:3520629, PubMed 11104667 -
Fc receptor mediated endocytosis of small soluble immunoglobulin G immune complexes in Kupffer and endothelial cells from rat liver
J Cell Sci, 113 ( Pt 18), 3255-66
DOI 10.1242/jcs.113.18.3255, PubMed 10954423 -
Probing pores with peptide plugs. Topology of membrane-inserted diphtheria toxin
J Gen Physiol, 115 (4), 417-20
DOI 10.1085/jgp.115.4.417, PubMed 10736309 -
Palaeoecological investigations towards the reconstruction of the history of forest clearances and coastal heathlands in south-western Norway
Veg. Hist. Archaeobot., 9 (4), 189-204
DOI 10.1007/BF01294634 -
Mutational analysis of the androgen receptor AF-2 (activation function 2) core domain reveals functional and mechanistic differences of conserved residues compared with other nuclear receptors
Mol Endocrinol, 14 (10), 1603-17
DOI 10.1210/mend.14.10.0544, PubMed 11043576 -
Cycling lipids
Curr Biol, 10 (2), R57-9
DOI 10.1016/s0960-9822(00)00279-7, PubMed 10662657 -
Endosomal localization and receptor dynamics determine tyrosine phosphorylation of hepatocyte growth factor-regulated tyrosine kinase substrate
Mol Cell Biol, 20 (20), 7685-92
DOI 10.1128/MCB.20.20.7685-7692.2000, PubMed 11003664 -
Externally added aFGF mutants do not require extensive unfolding for transport to the cytosol and the nucleus in NIH/3T3 cells
Biochemistry, 39 (49), 15091-100
DOI 10.1021/bi001831k, PubMed 11106487
Publications 1999
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Direct interaction of EEA1 with Rab5b
Eur J Biochem, 265 (1), 361-6
DOI 10.1046/j.1432-1327.1999.00743.x, PubMed 10491193 -
The endosome fusion regulator early-endosomal autoantigen 1 (EEA1) is a dimer
Biochem J, 338 ( Pt 2) (Pt 2), 539-43
DOI 10.1042/0264-6021:3380539, PubMed 10024533 -
Uptake and intracellular transport of acidic fibroblast growth factor: evidence for free and cytoskeleton-anchored fibroblast growth factor receptors
Mol Biol Cell, 10 (11), 3835-48
DOI 10.1091/mbc.10.11.3835, PubMed 10564275 -
Phosphoinositides in membrane traffic
Curr Opin Cell Biol, 11 (4), 460-5
DOI 10.1016/S0955-0674(99)80066-0, PubMed 10449332 -
Toxins that are activated by HIV type-1 protease through removal of a signal for degradation by the N-end-rule pathway
Biochem J, 343 Pt 1 (Pt 1), 199-207
DOI 10.1042/0264-6021:3430199, PubMed 10493930 -
Regulation of endocytic membrane traffic by phosphatidylinositol 3-phosphate
Biochem Soc Trans, 27 (4), 666-70
DOI 10.1042/bst0270666, PubMed 10917663 -
FYVE finger proteins as effectors of phosphatidylinositol 3-phosphate
Chem Phys Lipids, 98 (1-2), 87-94
DOI 10.1016/s0009-3084(99)00021-3, PubMed 10358931 -
Effects of mutations of a phosphorylation site in an exposed loop in acidic fibroblast growth factor
J Biol Chem, 274 (25), 18081-6
DOI 10.1074/jbc.274.25.18081, PubMed 10364261 -
[The Nobel Prize in physiology and medicine]
Tidsskr Nor Laegeforen, 119 (30), 4450
PubMed 10827478 -
The Rab5 effector EEA1 interacts directly with syntaxin-6
J Biol Chem, 274 (41), 28857-60
DOI 10.1074/jbc.274.41.28857, PubMed 10506127 -
FYVE-finger proteins--effectors of an inositol lipid
J Cell Sci, 112 ( Pt 23), 4175-83
DOI 10.1242/jcs.112.23.4175, PubMed 10564636 -
Fluid phase endocytosis and galactosyl receptor-mediated endocytosis employ different early endosomes
Biochim Biophys Acta, 1421 (2), 317-28
DOI 10.1016/s0005-2736(99)00134-0, PubMed 10518701 -
Dependence of ricin toxicity on translocation of the toxin A-chain from the endoplasmic reticulum to the cytosol
J Biol Chem, 274 (48), 34443-9
DOI 10.1074/jbc.274.48.34443, PubMed 10567425 -
Following angiogenin during angiogenesis: a journey from the cell surface to the nucleolus
Arch Immunol Ther Exp (Warsz), 47 (5), 299-305
PubMed 10604235
Publications 1998
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Modulation of the intracellular stability and toxicity of diphtheria toxin through degradation by the N-end rule pathway
EMBO J, 17 (2), 615-25
DOI 10.1093/emboj/17.2.615, PubMed 9430652 -
CREB binding protein is a coactivator for the androgen receptor and mediates cross-talk with AP-1
J Biol Chem, 273 (48), 31853-9
DOI 10.1074/jbc.273.48.31853, PubMed 9822653 -
FYVE fingers bind PtdIns(3)P
Nature, 394 (6692), 432-3
DOI 10.1038/28767, PubMed 9697764 -
Two distinct effectors of the small GTPase Rab5 cooperate in endocytic membrane fusion
EMBO J, 17 (7), 1930-40
DOI 10.1093/emboj/17.7.1930, PubMed 9524116 -
KDEL motif interacts with a specific sequence in mammalian erd2 receptor
Biochem Biophys Res Commun, 247 (2), 447-51
DOI 10.1006/bbrc.1998.8809, PubMed 9642148 -
Inability of the acidic fibroblast growth factor mutant K132E to stimulate DNA synthesis after translocation into cells
J Biol Chem, 273 (18), 11164-72
DOI 10.1074/jbc.273.18.11164, PubMed 9556604 -
Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor
Biochem J, 336 ( Pt 1) (Pt 1), 213-22
DOI 10.1042/bj3360213, PubMed 9806903 -
Variation in the proregion structure of heparin-binding EGF-like growth factor precursors
Gene, 212 (1), 1-4
DOI 10.1016/s0378-1119(98)00139-5, PubMed 9661657 -
Evidence that phosphatidylinositol 3-kinase and p70S6K protein are involved in differentiation of HL-60 cells induced by calcitriol
Anticancer Res, 18 (5A), 3507-14
PubMed 9858932 -
Existence of two crystal structures of the complex alpha-D-glucose center dot NaCl center dot H2O (2 : 1 : 1) verified by three-beam diffraction experiments
Acta Crystallogr. Sect. A, 54, 338-347
DOI 10.1107/S0108767397018849 -
Shiga and Shiga-like toxins
RECENT ADVANCES IN THE PATHOGENESIS OF GASTROINTESTINAL BACTERIAL INFECTIONS, 143-153 -
Syntaxin-16, a putative Golgi t-SNARE
Eur J Cell Biol, 75 (3), 223-31
DOI 10.1016/S0171-9335(98)80116-7, PubMed 9587053 -
EEA1 links PI(3)K function to Rab5 regulation of endosome fusion
Nature, 394 (6692), 494-8
DOI 10.1038/28879, PubMed 9697774 -
Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5
EMBO J, 17 (7), 1941-51
DOI 10.1093/emboj/17.7.1941, PubMed 9524117 -
Autoantibodies to a novel early endosome antigen 1
Clin Immunol Immunopathol, 86 (1), 81-7
DOI 10.1006/clin.1997.4455, PubMed 9434799 -
Characterization of membrane translocation by anthrax protective antigen
Biochemistry, 37 (45), 15737-46
DOI 10.1021/bi981436i, PubMed 9843379 -
Novel protein toxin-based strategy for development of cytotoxic T lymphocyte vaccines
Arch Immunol Ther Exp (Warsz), 46 (6), 341-6
PubMed 9883312 -
Rab17 regulates membrane trafficking through apical recycling endosomes in polarized epithelial cells
J Cell Biol, 140 (5), 1039-53
DOI 10.1083/jcb.140.5.1039, PubMed 9490718 -
Modulation by interleukin-2 of cellular response to fibroblast growth factor-1 in F69-3 fibrosarcoma cells
Exp Cell Res, 244 (1), 61-70
DOI 10.1006/excr.1998.4187, PubMed 9770349
Publications 1997
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Microtubules are involved in bafilomycin A1-induced tubulation and Rab5-dependent vacuolation of early endosomes
Eur J Cell Biol, 72 (2), 95-103
PubMed 9157016 -
Role of the disulfide bond in Shiga toxin A-chain for toxin entry into cells
J Biol Chem, 272 (17), 11414-9
DOI 10.1074/jbc.272.17.11414, PubMed 9111051 -
A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function
Cell, 90 (6), 1149-59
DOI 10.1016/s0092-8674(00)80380-3, PubMed 9323142 -
Structure-function relationship of the ion channel formed by diphtheria toxin in Vero cell membranes
J Membr Biol, 156 (2), 141-8
DOI 10.1007/s002329900196, PubMed 9075645 -
Membrane translocation of diphtheria toxin fragment A exploits early to late endosome trafficking machinery
Mol Microbiol, 23 (3), 445-57
DOI 10.1111/j.1365-2958.1997.tb02669.x, PubMed 9044279 -
Expression of mRNA for a short form of heparin-binding EGF-like growth factor
Gene, 195 (1), 81-6
DOI 10.1016/s0378-1119(97)00161-3, PubMed 9300824 -
1,25-Dihydroxyvitamin D3 induced activation and subsequent nuclear translocation of MAPK is upstream regulated by PKC in HL-60 cells
Biochem Biophys Res Commun, 241 (2), 419-26
DOI 10.1006/bbrc.1997.7832, PubMed 9425286 -
Effect of mutation of cytoplasmic receptor domain and of genistein on transport of acidic fibroblast growth factor into cells
Oncogene, 15 (5), 525-36
DOI 10.1038/sj.onc.1201226, PubMed 9247306 -
Role of Rab GTPases in membrane traffic
Int Rev Cytol, 176, 1-85
DOI 10.1016/s0074-7696(08)61608-3, PubMed 9394917 -
[Self-inhibiting N-glycosidase activity of shigella toxin]
Mol Biol (Mosk), 31 (3), 528-35
PubMed 9297098 -
Self-inhibition of N-glycosidase activity of shiga toxin
Mol. Biol., 31 (3), 441-447 -
Retrograde transport of mutant ricin to the endoplasmic reticulum with subsequent translocation to cytosol
Proc Natl Acad Sci U S A, 94 (8), 3783-8
DOI 10.1073/pnas.94.8.3783, PubMed 9108055 -
Diphtheria toxin as a molecular tool in the study of acidic fibroblast growth factor signalling
Arch Immunol Ther Exp (Warsz), 45 (5-6), 391-409
PubMed 9437495
Publications 1996
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Clathrin-dependent and clathrin-independent endocytosis in liver cells
Z Gastroenterol, 34 Suppl 3, 92-4
PubMed 8767476 -
Ability of methotrexate to inhibit translocation to the cytosol of dihydrofolate reductase fused to diphtheria toxin
Biochem J, 313 ( Pt 2) (Pt 2), 647-53
DOI 10.1042/bj3130647, PubMed 8573105 -
GPI-anchored diphtheria toxin receptor allows membrane translocation of the toxin without detectable ion channel activity
EMBO J, 15 (4), 725-34
DOI 10.1002/j.1460-2075.1996.tb00408.x, PubMed 8631294 -
Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger
J Biol Chem, 271 (39), 24048-54
DOI 10.1074/jbc.271.39.24048, PubMed 8798641 -
Isolation and characterization of early endosomes, late endosomes and terminal lysosomes: their role in protein degradation
J Cell Sci, 109 ( Pt 12), 2905-14
DOI 10.1242/jcs.109.12.2905, PubMed 9013338 -
[The Anders Jahre medical awarad 1996]
Tidsskr Nor Laegeforen, 116 (23), 2804-6
PubMed 8928170 -
Retrograde transport of acidic fibroblast growth factor as a part of the growth factor signaling
Arch Immunol Ther Exp (Warsz), 44 (4), 201-7
PubMed 9017159 -
Stimulation of proliferation of a human osteosarcoma cell line by exogenous acidic fibroblast growth factor requires both activation of receptor tyrosine kinase and growth factor internalization
Mol Cell Biol, 16 (1), 270-80
DOI 10.1128/MCB.16.1.270, PubMed 8524304
Publications 1995
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Oxidant-induced stress response in lymphoid cells
Biochem Mol Biol Int, 37 (2), 273-81
PubMed 8673010 -
CELL PENETRATION OF BACTERIAL PROTEIN TOXINS - RESPONSE
Trends Microbiol., 3 (5), 167-168
DOI 10.1016/S0966-842X(00)88912-X -
Cell-mediated reduction and incomplete membrane translocation of diphtheria toxin mutants with internal disulfides in the A fragment
J Biol Chem, 270 (35), 20787-93
DOI 10.1074/jbc.270.35.20787, PubMed 7657662 -
Farnesylation of CaaX-tagged diphtheria toxin A-fragment as a measure of transfer to the cytosol
Biochemistry, 34 (35), 11152-9
DOI 10.1021/bi00035a021, PubMed 7669773 -
Role of processing and intracellular transport for optimal toxicity of Shiga toxin and toxin mutants
Exp Cell Res, 218 (1), 39-49
DOI 10.1006/excr.1995.1128, PubMed 7737376 -
Inhibition of asialoglycoprotein endocytosis and degradation in rat hepatocytes by protein phosphatase inhibitors
Biochem J, 311 ( Pt 1) (Pt 1), 317-26
DOI 10.1042/bj3110317, PubMed 7575471 -
Involvement of early and late lysosomes in the degradation of mannosylated ligands by rat liver endothelial cells
Exp Cell Res, 216 (2), 290-8
DOI 10.1006/excr.1995.1037, PubMed 7843273 -
Diphtheria toxin endocytosis and membrane translocation are dependent on the intact membrane-anchored receptor (HB-EGF precursor): studies on the cell-associated receptor cleaved by a metalloprotease in phorbol-ester-treated cells
Biochem J, 310 ( Pt 1) (Pt 1), 285-9
DOI 10.1042/bj3100285, PubMed 7646457 -
EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif
J Biol Chem, 270 (22), 13503-11
DOI 10.1074/jbc.270.22.13503, PubMed 7768953 -
Yeast Ypt51p and mammalian Rab5: counterparts with similar function in the early endocytic pathway
J Cell Sci, 108 ( Pt 11), 3509-21
DOI 10.1242/jcs.108.11.3509, PubMed 8586662 -
Induction of toxin sensitivity in insect cells by infection with baculovirus encoding diphtheria toxin receptor
J Biol Chem, 270 (28), 16879-85
DOI 10.1074/jbc.270.28.16879, PubMed 7622504 -
The GDP/GTP cycle of Rab5 in the regulation of endocytotic membrane traffic
Cold Spring Harb Symp Quant Biol, 60, 211-20
DOI 10.1101/sqb.1995.060.01.024, PubMed 8824393 -
Translocation of cytosol of exogenous, CAAX-tagged acidic fibroblast growth factor
J Biol Chem, 270 (51), 30680-5
DOI 10.1074/jbc.270.51.30680, PubMed 8530506
Publications 1994
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The involvement of the small GTP-binding protein Rab5a in neuronal endocytosis
Neuron, 13 (1), 11-22
DOI 10.1016/0896-6273(94)90456-1, PubMed 8043272 -
Diphtheria toxin at low pH depolarizes the membrane, increases the membrane conductance and induces a new type of ion channel in Vero cells
EMBO J, 13 (19), 4433-9
DOI 10.1002/j.1460-2075.1994.tb06765.x, PubMed 7523112 -
Inhibition of membrane translocation of diphtheria toxin A-fragment by internal disulfide bridges
J Biol Chem, 269 (11), 8402-7
PubMed 8132565 -
Intermediates in translocation of diphtheria toxin across the plasma membrane
J Biol Chem, 269 (6), 4648-52
PubMed 7508447 -
Role of three rab5-like GTPases, Ypt51p, Ypt52p, and Ypt53p, in the endocytic and vacuolar protein sorting pathways of yeast
J Cell Biol, 125 (2), 283-98
DOI 10.1083/jcb.125.2.283, PubMed 8163546 -
Dual mode of signal transduction by externally added acidic fibroblast growth factor
Cell, 76 (6), 1039-51
DOI 10.1016/0092-8674(94)90381-6, PubMed 7511061
Publications 1993
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Membrane translocation of diphtheria toxin A-fragment: role of carboxy-terminal region
Biochemistry, 32 (1), 83-90
DOI 10.1021/bi00052a012, PubMed 8418864 -
A chimeric toxin to study the role of the 21 kDa GTP binding protein rho in the control of actin microfilament assembly
EMBO J, 12 (3), 921-31
DOI 10.1002/j.1460-2075.1993.tb05733.x, PubMed 8458345 -
Activation of the food derived carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by rat pleural cavity inflammatory cells
Carcinogenesis, 14 (12), 2457-62
DOI 10.1093/carcin/14.12.2457, PubMed 8269612 -
PRELYSOSOMAL DEGRADATION IN RAT-LIVER ENDOTHELIAL-CELLS
CELLS OF THE HEPATIC SINUSOID, VOL 4, 426-430 -
Subcloning and characterization of the binding domain of fragment B of diphtheria toxin
Biochem J, 294 ( Pt 3) (Pt 3), 663-6
DOI 10.1042/bj2940663, PubMed 8379922 -
New cloning opportunities with the use of noncomplementary SfiI adaptors
Biotechniques, 15 (6), 980-2
PubMed 8292350 -
Rapid increase in pH set-point of the Na(+)-in-dependent chloride/bicarbonate antiporter in Vero cells exposed to heat shock
J Membr Biol, 134 (2), 143-53
DOI 10.1007/BF00232750, PubMed 8411117 -
Entry of protein toxins in polarized epithelial cells
Cancer Res, 53 (8), 1755-60
PubMed 8467493 -
Rapid cellular removal of a membrane-inserted foreign polypeptide
Biochem J, 291 ( Pt 2) (Pt 2), 473-7
DOI 10.1042/bj2910473, PubMed 8484728 -
Protein toxins acting on intracellular targets: cellular uptake and translocation to the cytosol
Med Microbiol Immunol, 182 (2), 51-61
DOI 10.1007/BF00189373, PubMed 8392658 -
Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins
J Biol Chem, 268 (24), 18143-50
PubMed 8349690 -
Rab GTPases in vesicular transport
Curr Opin Cell Biol, 5 (4), 613-20
DOI 10.1016/0955-0674(93)90130-i, PubMed 8257602
Publications 1992
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Replacement of negative by positive charges in the presumed membrane-inserted part of diphtheria toxin B fragment. Effect on membrane translocation and on formation of cation channels
J Biol Chem, 267 (17), 12284-90
PubMed 1376320 -
Comparative studies on internalization of gold labelled mistletoe lectin I (MLI), its subunits, and of an immunotoxin into mouse L 1210V leukemia cells
Acta Histochem, 92 (1), 46-53
DOI 10.1016/S0065-1281(11)80140-6, PubMed 1580141 -
Membrane translocation of diphtheria toxin carrying passenger protein domains
Infect Immun, 60 (8), 3296-302
DOI 10.1128/iai.60.8.3296-3302.1992, PubMed 1639497 -
Entry of ADP-ribosylating toxins into cells
Curr Top Microbiol Immunol, 175, 1-26
DOI 10.1007/978-3-642-76966-5_1, PubMed 1378368 -
Shiga toxin: biochemistry, genetics, mode of action, and role in pathogenesis
Curr Top Microbiol Immunol, 180, 65-94
DOI 10.1007/978-3-642-77238-2_4, PubMed 1324134 -
Genetically engineered toxins in perspective
Targeted Diagn Ther, 7, 465-77
PubMed 1633307 -
The activity of two immunotoxins composed of monoclonal antibody MoAb-16 and A-chain of ricin (MoAb-16-RTA) or A-chain of mistletoe lectin I (MoAb-16-MLIA)
Arch Immunol Ther Exp (Warsz), 40 (3-4), 223-7
PubMed 1300987 -
Association between diphtheria toxin A- and B-fragment and their fusion proteins
Biochem J, 281 ( Pt 3) (Pt 3), 619-25
DOI 10.1042/bj2810619, PubMed 1536643 -
Interactions of diphtheria toxin B-fragment with cells. Role of amino- and carboxyl-terminal regions
J Biol Chem, 267 (13), 8957-62
PubMed 1374382 -
Tight folding of acidic fibroblast growth factor prevents its translocation to the cytosol with diphtheria toxin as vector
EMBO J, 11 (13), 4835-42
DOI 10.1002/j.1460-2075.1992.tb05589.x, PubMed 1281450
Publications 1991
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Evidence for involvement of protein kinase C in regulation of intracellular pH by Cl-/HCO-3 antiport
J Membr Biol, 119 (2), 179-86
DOI 10.1007/BF01871417, PubMed 2046087 -
Entry of diphtheria toxin-protein A chimeras into cells
J Biol Chem, 266 (26), 17446-53
PubMed 1894632 -
Effect of monensin on ricin and fluid phase transport in polarized MDCK cells
J Cell Biochem, 47 (3), 251-60
DOI 10.1002/jcb.240470311, PubMed 1791187 -
Insertion of diphtheria toxin B-fragment into the plasma membrane at low pH. Characterization and topology of inserted regions
J Biol Chem, 266 (4), 2652-9
PubMed 1990012 -
Bacterial protein toxins acting on intracellular targets
Semin Cell Biol, 2 (1), 7-14
PubMed 1954345 -
Peptides fused to the amino-terminal end of diphtheria toxin are translocated to the cytosol
J Cell Biol, 113 (5), 1025-32
DOI 10.1083/jcb.113.5.1025, PubMed 2040642 -
Elimination of the disulphide bridge in fragment B of diphtheria toxin: effect on membrane insertion, channel formation, and ATP binding
Mol Microbiol, 5 (3), 595-606
DOI 10.1111/j.1365-2958.1991.tb00730.x, PubMed 1646374 -
Internalization and action of an immunotoxin containing mistletoe lectin A-chain
Cancer Res, 51 (3), 916-20
PubMed 1988131
Publications 1990
-
Translocation of diphtheria toxin to the cytosol and formation of cation selective channels
J Physiol (Paris), 84 (3), 191-6
PubMed 1705980 -
Protein toxins with intracellular targets
Microb Pathog, 8 (3), 163-8
DOI 10.1016/0882-4010(90)90043-p, PubMed 1696341 -
Mouse L1210V leukemia as a model to analyse efficiency of leukemic cell elimination by immunotoxin, antibody and complement, and cytostatic agents
In Vivo, 4 (3), 209-13
PubMed 2133264 -
Role of Na(+)-H+ and Cl(-)-HCO3- antiports in the regulation of cytosolic pH near neutrality
Am J Physiol, 258 (6 Pt 1), C1117-26
DOI 10.1152/ajpcell.1990.258.6.C1117, PubMed 2163200 -
Regulation of Na+/H+ and Cl-/HCO3- antiports in Vero cells
J Cell Physiol, 143 (1), 178-87
DOI 10.1002/jcp.1041430125, PubMed 2156872
Publications 1989
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Internalized ricin and the plasma membrane glycoprotein MAM-6 colocalize in the trans-Golgi network of T47D human breast carcinoma cells
Exp Cell Res, 185 (2), 373-86
DOI 10.1016/0014-4827(89)90307-8, PubMed 2689197 -
Monoclonal antibodies against human haptoglobin
Hybridoma, 8 (5), 551-60
DOI 10.1089/hyb.1989.8.551, PubMed 2478448 -
Membrane interactions of diphtheria toxin analyzed using in vitro synthesized mutants
EMBO J, 8 (10), 2843-8
DOI 10.1002/j.1460-2075.1989.tb08431.x, PubMed 2684631 -
Role of anions in low pH-induced translocation of diphtheria toxin
J Biol Chem, 264 (19), 11367-72
PubMed 2500440 -
Translocation of diphtheria toxin A-fragment to the cytosol. Role of the site of interfragment cleavage
J Biol Chem, 264 (26), 15709-13
PubMed 2768283 -
Immunotoxins--entry into cells and mechanisms of action
Immunol Today, 10 (9), 291-5
PubMed 2686677 -
Formation of active diphtheria toxin in vitro based on ligated fragments of cloned mutant genes
J Biol Chem, 264 (22), 12747-51
PubMed 2753882 -
FORMATION OF ACTIVE DIPHTHERIA-TOXIN INVITRO BASED ON LIGATED FRAGMENTS OF CLONED MUTANT-GENES
J. Biol. Chem., 264 (22), 12749-12751 -
The Thomsen-Friedenreich antigen on human urothelial cell lines detectable by peanut lectin and monoclonal antibody raised against human glycophorin A
Anticancer Res, 9 (1), 103-7
PubMed 2650614 -
Endocytosis from coated pits of Shiga toxin: a glycolipid-binding protein from Shigella dysenteriae 1
J Cell Biol, 108 (4), 1331-43
DOI 10.1083/jcb.108.4.1331, PubMed 2564398 -
Control of coated-pit function by cytoplasmic pH
Methods Cell Biol, 32, 365-82
DOI 10.1016/s0091-679x(08)61181-4, PubMed 2575206 -
Permeabilization of the plasma membrane by deletion mutants of diphtheria toxin
EMBO J, 8 (10), 2849-53
DOI 10.1002/j.1460-2075.1989.tb08432.x, PubMed 2479538 -
Effect of anti-inflammatory analgesic drugs on the regulation of cytosolic pH by anion antiport
J Pharmacol Exp Ther, 248 (3), 1197-206
PubMed 2703970 -
Inhibition of chloride/bicarbonate antiports in monkey kidney cells (Vero) by non-steroidal anti-inflammatory drugs
Biochem Pharmacol, 38 (20), 3583-91
DOI 10.1016/0006-2952(89)90131-7, PubMed 2818647 -
The ways of endocytosis
Int Rev Cytol, 117, 131-77
DOI 10.1016/s0074-7696(08)61336-4, PubMed 2573583 -
[Endocytosis, intracellular transport and sorting of proteins]
Nord Med, 104 (1), 9-11
PubMed 2911460
Publications 1988
-
Degradation of the human erythrocyte membrane band 3 studied with monoclonal antibody directed against an epitope on the cytoplasmic fragment of band 3
Eur J Biochem, 174 (4), 647-54
DOI 10.1111/j.1432-1033.1988.tb14147.x, PubMed 2455637 -
Characterization of a toxic lectin in Iscador, a mistletoe preparation with alleged cancerostatic properties
Oncology, 45 (3), 172-9
DOI 10.1159/000226557, PubMed 3368193 -
Low pH-induced release of diphtheria toxin A-fragment in Vero cells. Biochemical evidence for transfer to the cytosol
J Biol Chem, 263 (5), 2518-25
PubMed 3339019 -
Diphtheria toxin entry: protein translocation in the reverse direction
Trends Biochem Sci, 13 (9), 348-51
DOI 10.1016/0968-0004(88)90105-3, PubMed 3072713 -
How protein toxins enter and kill cells
Cancer Treat Res, 37, 39-73
DOI 10.1007/978-1-4613-1083-9_4, PubMed 2908634 -
Role of chloride/bicarbonate antiport in the control of cytosolic pH. Cell-line differences in activity and regulation of antiport
J Biol Chem, 263 (23), 11117-25
PubMed 3403517 -
Diphtheria toxin-induced channels in Vero cells selective for monovalent cations
J Biol Chem, 263 (25), 12352-9
PubMed 2457582 -
Inhibition of endocytosis from coated pits by acidification of the cytosol
J Cell Biochem, 36 (1), 73-81
DOI 10.1002/jcb.240360108, PubMed 2893802 -
Requirement of specific receptors for efficient translocation of diphtheria toxin A fragment across the plasma membrane
J Biol Chem, 263 (26), 13449-55
PubMed 3417666 -
Estimation of the amount of internalized ricin that reaches the trans-Golgi network
J Cell Biol, 106 (2), 253-67
DOI 10.1083/jcb.106.2.253, PubMed 2892843 -
Two monoclonal antibodies recognizing different epitopes of blood group N antigen
Arch Immunol Ther Exp (Warsz), 36 (5), 623-32
PubMed 2478103
Publications 1987
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Selective inhibition of sodium-linked and sodium-independent bicarbonate/chloride antiport in Vero cells
J Biol Chem, 262 (16), 7486-91
PubMed 3584123 -
Effect of reduced endocytosis induced by hypotonic shock and potassium depletion on the infection of Hep 2 cells by picornaviruses
J Cell Physiol, 131 (1), 14-22
DOI 10.1002/jcp.1041310104, PubMed 3032992 -
Effect of potassium depletion of Hep 2 cells on intracellular pH and on chloride uptake by anion antiport
J Cell Physiol, 131 (1), 6-13
DOI 10.1002/jcp.1041310103, PubMed 3571337 -
Cell-mediated reduction of the interfragment disulfide in nicked diphtheria toxin. A new system to study toxin entry at low pH
J Biol Chem, 262 (21), 10339-45
PubMed 3112141 -
Closing in on ricin action
Nature, 328 (6130), 474-5
DOI 10.1038/328474b0, PubMed 3614350 -
Bicarbonate/chloride antiport in Vero cells: II. Mechanisms for bicarbonate-dependent regulation of intracellular pH
J Cell Physiol, 132 (2), 192-202
DOI 10.1002/jcp.1041320203, PubMed 3624315 -
Effect of intracellular pH on the rate of chloride uptake and efflux in different mammalian cell lines
Biochemistry, 26 (10), 2778-85
DOI 10.1021/bi00384a019, PubMed 3606992 -
Acidification of the cytosol inhibits endocytosis from coated pits
J Cell Biol, 105 (2), 679-89
DOI 10.1083/jcb.105.2.679, PubMed 2887575 -
Bicarbonate/chloride antiport in Vero cells: I. Evidence for both sodium-linked and sodium-independent exchange
J Cell Physiol, 132 (2), 183-91
DOI 10.1002/jcp.1041320202, PubMed 3624314 -
Delivery of internalized ricin from endosomes to cisternal Golgi elements is a discontinuous, temperature-sensitive process
Exp Cell Res, 171 (1), 137-52
DOI 10.1016/0014-4827(87)90257-6, PubMed 3622628 -
Formation and activity of covalent conjugates of poliovirus and ligands binding to cell surface structures
Exp Cell Res, 170 (2), 483-90
DOI 10.1016/0014-4827(87)90322-3, PubMed 3036553
Publications 1986
-
Interactions between diphtheria toxin entry and anion transport in vero cells. III. Effect on toxin binding and anion transport of tumor-promoting phorbol esters, vanadate, fluoride, and salicylate
J Biol Chem, 261 (4), 1562-9
PubMed 3632976 -
Interactions between diphtheria toxin entry and anion transport in Vero cells. I. Anion antiport in Vero cells
J Biol Chem, 261 (4), 1542-52
PubMed 3944100 -
Interactions between diphtheria toxin entry and anion transport in Vero cells. II. Inhibition of anion antiport by diphtheria toxin
J Biol Chem, 261 (4), 1553-61
PubMed 3944101 -
pH-regulated anion antiport in nucleated mammalian cells
J Cell Biol, 102 (3), 967-71
DOI 10.1083/jcb.102.3.967, PubMed 3949885 -
Interactions between diphtheria toxin entry and anion transport in Vero cells. IV. Evidence that entry of diphtheria toxin is dependent on efficient anion transport
J Biol Chem, 261 (4), 1570-5
PubMed 2418015 -
REQUIREMENT OF A TRANSMEMBRANE PH GRADIENT FOR THE ENTRY OF DIPHTHERIA-TOXIN INTO CELLS AT LOW PH
J. Biol. Chem., 261 (25), 1639-1644 -
Ability of inhibitors of glycosylation and protein synthesis to sensitize cells to abrin, ricin, Shigella toxin, and Pseudomonas toxin
Cancer Res, 46 (12 Pt 1), 6418-22
PubMed 3096563 -
Requirement of a transmembrane pH gradient for the entry of diphtheria toxin into cells at low pH
J Biol Chem, 261 (25), 11639-44
PubMed 3745160 -
Routing of internalized ricin and ricin conjugates to the Golgi complex
J Cell Biol, 102 (1), 37-47
DOI 10.1083/jcb.102.1.37, PubMed 3001103
Publications 1985
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Entry of diphtheria toxin linked to concanavalin A into primate and murine cells
J Cell Physiol, 122 (2), 193-9
DOI 10.1002/jcp.1041220205, PubMed 3844014 -
Tumor-promoting phorbol esters and vanadate alter the sensitivity of HeLa S3 cells to poliovirus type 1
Exp Cell Res, 160 (1), 240-4
DOI 10.1016/0014-4827(85)90253-8, PubMed 2995095 -
Evidence that membrane phospholipids and protein are required for binding of diphtheria toxin in Vero cells
Biochim Biophys Acta, 846 (3), 334-41
DOI 10.1016/0167-4889(85)90003-5, PubMed 4041483 -
Entry mechanisms of protein toxins and picornaviruses
Biochem Soc Symp, 50, 171-91
PubMed 3915869 -
ENTRY MECHANISMS OF PROTEIN TOXINS AND PICORNAVIRUSES
Biochem. Soc. Symp. (50), 171-191 -
Effect of the chaotropic anions thiocyanate and perchlorate on the entry of ricin into Vero cells
Biochem J, 228 (2), 521-3
DOI 10.1042/bj2280521, PubMed 2990449 -
Effect of potassium depletion of cells on their sensitivity to diphtheria toxin and pseudomonas toxin
J Cell Physiol, 124 (1), 54-60
DOI 10.1002/jcp.1041240110, PubMed 3930519 -
Properties of volkensin, a toxic lectin from Adenia volkensii
J Biol Chem, 260 (27), 14589-95
PubMed 3932357 -
PROPERTIES OF VOLKENSIN, A TOXIC LECTIN FROM ADENIA-VOLKENSII
J. Biol. Chem., 260 (27), 4589-4595 -
Receptor-mediated endocytosis of a ricin-colloidal gold conjugate in vero cells. Intracellular routing to vacuolar and tubulo-vesicular portions of the endosomal system
Exp Cell Res, 159 (2), 287-304
DOI 10.1016/s0014-4827(85)80003-3, PubMed 2863159
Publications 1984
-
Requirements for entry of poliovirus RNA into cells at low pH
EMBO J, 3 (9), 1945-50
DOI 10.1002/j.1460-2075.1984.tb02074.x, PubMed 6092049 -
Different pH requirements for entry of the two picornaviruses, human rhinovirus 2 and murine encephalomyocarditis virus
Virology, 139 (2), 346-57
DOI 10.1016/0042-6822(84)90380-5, PubMed 6097029 -
Mechanism of entry into the cytosol of poliovirus type 1: requirement for low pH
J Cell Biol, 98 (4), 1194-200
DOI 10.1083/jcb.98.4.1194, PubMed 6325467 -
Dimethyl sulphoxide protects cells against polypeptide toxins and poliovirus
Biochem J, 219 (3), 935-40
DOI 10.1042/bj2190935, PubMed 6331401 -
Receptor-mediated entry of protein toxins into cells
Acta Histochem Suppl, 29, 79-94
PubMed 6144140 -
Anion requirement and effect of anion transport inhibitors on the response of vero cells to diphtheria toxin and modeccin
J Cell Physiol, 119 (1), 7-14
DOI 10.1002/jcp.1041190103, PubMed 6707104 -
Evidence that diphtheria toxin and modeccin enter the cytosol from different vesicular compartments
J Cell Biol, 98 (3), 963-70
DOI 10.1083/jcb.98.3.963, PubMed 6699094 -
Effect of malignant transformation, retinoic acid, trifluoperazine, and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W7) on the sensitivity of rodent cells to Pseudomonas toxin
Cancer Res, 44 (11), 4919-23
PubMed 6435858 -
Calmodulin antagonists sensitize cells to pseudomonas toxin
J Cell Physiol, 119 (1), 15-22
DOI 10.1002/jcp.1041190104, PubMed 6707099
Publications 1983
-
Animal toxicity of Shigella dysenteriae cytotoxin: evidence that the neurotoxic, enterotoxic, and cytotoxic activities are due to one toxin
J Immunol, 130 (1), 380-4
PubMed 6336624 -
Entry of Shigella dysenteriae toxin into HeLa cells
Infect Immun, 42 (2), 771-7
DOI 10.1128/iai.42.2.771-777.1983, PubMed 6358031 -
Dansylcadaverine eliminates calmodulin stimulation of phosphodiesterase
Biochem Biophys Res Commun, 117 (2), 562-7
DOI 10.1016/0006-291x(83)91237-8, PubMed 6318763 -
Preparation and properties of a hybrid toxin of modeccin A-chain and ricin B-chain
Biochim Biophys Acta, 761 (3), 296-302
DOI 10.1016/0304-4165(83)90080-6, PubMed 6652111
Publications 1982
-
The toxic lectin modeccin
Methods Enzymol, 83, 357-62
DOI 10.1016/0076-6879(82)83030-9, PubMed 6178935 -
Isolation and characterization of viscumin, a toxic lectin from Viscum album L. (mistletoe)
J Biol Chem, 257 (22), 13263-70
PubMed 7142144 -
Entry of the toxic proteins abrin, modeccin, ricin, and diphtheria toxin into cells. I. Requirement for calcium
J Biol Chem, 257 (13), 7495-503
PubMed 6806276 -
Entry of the toxic proteins abrin, modeccin, ricin, and diphtheria toxin into cells. II. Effect of pH, metabolic inhibitors, and ionophores and evidence for toxin penetration from endocytotic vesicles
J Biol Chem, 257 (13), 7504-13
PubMed 7085634 -
Action of viscumin, a toxic lectin from mistletoe, on cells in culture
J Biol Chem, 257 (22), 13271-7
PubMed 7142145 -
Preparation and properties of chimeric toxins prepared from the constituent polypeptides of diphtheria toxin and ricin. Evidence for entry of ricin A-chain via the diphtheria toxin pathway
J Biol Chem, 257 (16), 9733-9
PubMed 7107588
Publications 1981
-
Radioimmunoassays of abrin and ricin in blood
J Toxicol Environ Health, 8 (3), 409-17
DOI 10.1080/15287398109530079, PubMed 7345165 -
Directing toxins to cancer cells
Nature, 290 (5802), 84
DOI 10.1038/290084a0, PubMed 7207602 -
Chimeric toxins
Pharmacol Ther, 15 (3), 355-81
DOI 10.1016/0163-7258(81)90050-4, PubMed 7345440 -
Subunit structure of Shigella cytotoxin
J Biol Chem, 256 (16), 8732-8
PubMed 7021550 -
The cytotoxic activity of Shigella toxin. Evidence for catalytic inactivation of the 60 S ribosomal subunit
J Biol Chem, 256 (16), 8739-44
PubMed 6894922 -
Rapid entry of nicked diphtheria toxin into cells at low pH. Characterization of the entry process and effects of low pH on the toxin molecule
J Biol Chem, 256 (17), 9068-76
PubMed 7263699 -
Effects of retinoids and phorbol esters on the sensitivity of different cell lines to the polypeptide toxins modeccin, abrin, ricin and diphtheria toxin
Biochem J, 194 (3), 821-7
DOI 10.1042/bj1940821, PubMed 7306026
Publications 1980
-
Interaction of Shigella shigae cytotoxin with receptors on sensitive and insensitive cells
J Recept Res, 1 (2), 199-213
DOI 10.3109/10799898009044098, PubMed 6895387 -
Entry of lethal doses of abrin, ricin and modeccin into the cytosol of HeLa cells
Exp Cell Res, 126 (2), 321-6
DOI 10.1016/0014-4827(80)90270-0, PubMed 7363949 -
Pathways involved in fluid phase and adsorptive endocytosis in neuroblastoma
J Cell Biol, 87 (3 Pt 1), 579-88
DOI 10.1083/jcb.87.3.579, PubMed 7462317 -
Isolation and characterization of Shigella shigae cytotoxin
J Biol Chem, 255 (1), 284-9
PubMed 7350160 -
Diphtheria toxin entry into cells is facilitated by low pH
J Cell Biol, 87 (3 Pt 1), 828-32
DOI 10.1083/jcb.87.3.828, PubMed 7462324 -
Gelonin, a new inhibitor of protein synthesis, nontoxic to intact cells. Isolation, characterization, and preparation of cytotoxic complexes with concanavalin A
J Biol Chem, 255 (14), 6947-53
PubMed 7391060 -
Human embryonal carcinoma grown in athymic mice and in vitro
Cancer Res, 40 (3), 949-53
PubMed 7471109 -
A human melanoma cell line established from xenograft in athymic mice
Br J Cancer, 41 (5), 724-33
DOI 10.1038/bjc.1980.134, PubMed 7426299 -
In vitro sensitivity of human melanoma xenografts to cytotoxic drugs. Correlation with in vivo chemosensitivity
Int J Cancer, 26 (6), 717-22
DOI 10.1002/ijc.2910260604, PubMed 7216540
Publications 1979
-
Fidelity of protein synthesis in vitro is increased in the presence of spermidine
FEBS Lett, 101 (1), 93-6
DOI 10.1016/0014-5793(79)81302-2, PubMed 446744 -
Elongation-factor-2-induced sensitization of ribosomes to modeccin. Evidence for specific binding of elongation factor 2 to ribosomes in the absence of nucleotides
Eur J Biochem, 93 (3), 447-52
DOI 10.1111/j.1432-1033.1979.tb12842.x, PubMed 421687 -
Effect of temperature on the uptake, excretion and degradation of abrin and ricin by HeLa cells
Exp Cell Res, 121 (1), 15-25
DOI 10.1016/0014-4827(79)90439-7, PubMed 446525 -
Inhibitory effect of ammonium chloride and chloroquine on the entry of the toxic lectin modeccin into HeLa cells
Biochem Biophys Res Commun, 90 (2), 648-55
DOI 10.1016/0006-291x(79)91284-1, PubMed 508328
Publications 1978
-
Toxic and nontoxic lectins from Abrus precatorius
Methods Enzymol, 50, 323-30
DOI 10.1016/0076-6879(78)50036-0, PubMed 661585 -
Ricin and ricinus agglutinin, toxic lectins from castor bean
Methods Enzymol, 50, 330-5
DOI 10.1016/0076-6879(78)50037-2, PubMed 661586 -
Purification and characterization of the highly toxic lectin modeccin
J Biol Chem, 253 (14), 5069-73
PubMed 97288 -
ABRIN AND RICIN-2 TOXIC LECTINS
Trends Biochem.Sci., 3 (1), 7-10
DOI 10.1016/S0968-0004(78)92494-5 -
On the mechanism of toxin resistance in cell variants resistant to abrin and ricin
Eur J Biochem, 88 (1), 7-15
DOI 10.1111/j.1432-1033.1978.tb12417.x, PubMed 566668 -
Properties and action mechanism of the toxic lectin modeccin: interaction with cell lines resistant to modeccin, abrin, and ricin
J Supramol Struct, 9 (1), 15-25
DOI 10.1002/jss.400090103, PubMed 732310 -
[Teratocarcinoma as a model system in studies of malignancy and differentiation]
Tidsskr Nor Laegeforen, 98 (22), 998-1001
PubMed 684708 -
Interactions between abrus lectins and Sephadex particles possessing immobilized desialylated fetuin. Model studies of the interaction of lectins with cell surface receptors
Eur J Biochem, 88 (1), 307-13
DOI 10.1111/j.1432-1033.1978.tb12451.x, PubMed 78847 -
Binding, uptake and degradation of the toxic proteins abrin and ricin by toxin-resistant cell variants
Eur J Biochem, 82 (1), 13-23
DOI 10.1111/j.1432-1033.1978.tb11992.x, PubMed 620666 -
Chemical modifications of the toxic lectins abrin and ricin
Eur J Biochem, 84 (2), 323-31
DOI 10.1111/j.1432-1033.1978.tb12171.x, PubMed 639792
Publications 1977
-
Studies on the accessability of ribosomes to inactivation by the toxic lectins abrin and ricin
Eur J Biochem, 74 (2), 209-15
DOI 10.1111/j.1432-1033.1977.tb11383.x, PubMed 856578 -
Inhibitory effect of abrin and ricin on the growth of transplantable murine tumors and of abrin on human cancers in nude mice
Cancer Res, 37 (12), 4559-67
PubMed 922739 -
Modeccin--a plant toxin inhibiting protein synthesis
Biochem Biophys Res Commun, 79 (4), 1176-83
DOI 10.1016/0006-291x(77)91130-5, PubMed 603653 -
Effect of abrin on peptide chain initiation
Eur J Biochem, 79 (2), 559-64
DOI 10.1111/j.1432-1033.1977.tb11840.x, PubMed 243461
Publications 1976
-
Protective effect of elongation factor 2 on the inactivation of ribosomes by the toxic lectins abrin and ricin
Eur J Biochem, 64 (2), 437-43
DOI 10.1111/j.1432-1033.1976.tb10320.x, PubMed 1278169 -
Toxicity, distribution and elimination of the cancerostatic lectins abrin and ricin after parenteral injection into mice
Br J Cancer, 34 (4), 418-25
DOI 10.1038/bjc.1976.187, PubMed 974006 -
ABRIN AND RICIN - STRUCTURE AND MECHANISM OF ACTION OF 2 TOXIC LECTINS
Bull. Inst. Pasteur, 74 (1), 85-99 -
Rates of different steps involved in the inhibition of protein synthesis by the toxic lectins abrin and ricin
J Biol Chem, 251 (13), 3985-92
PubMed 932017 -
Kinetics of binding of the toxic lectins abrin and ricin to surface receptors of human cells
J Biol Chem, 251 (13), 3977-84
PubMed 6468
Publications 1975
-
On the mechanism of protein-synthesis inhibition by abrin and ricin. Inhibition of the GTP-hydrolysis site on the 60-S ribosomal subunit
Eur J Biochem, 59 (2), 573-80
DOI 10.1111/j.1432-1033.1975.tb02484.x, PubMed 128455 -
Stimulation of human lymphocytes by galactose-specific abrus and ricinus lectins
J Immunol, 115 (4), 1045-8
PubMed 1176765 -
INTERACTIONS BETWEEN RICINUS AGGLUTININ AND HUMAN PLASMA-PROTEINS
Scand. J. Immunol. (2), 125-134 -
Cleavage of adenovirus-5 DNA by an endonuclease from Haemophilus parainfluenzae
FEBS Lett, 57 (2), 153-7
DOI 10.1016/0014-5793(75)80705-8, PubMed 1175785 -
Ribosome inactivation by the toxic lectins abrin and ricin. Kinetics of the enzymic activity of the toxin A-chains
Eur J Biochem, 60 (1), 281-8
DOI 10.1111/j.1432-1033.1975.tb21001.x, PubMed 1204642 -
Studies on the structure and properties of the lectins from Abrus precatorius and Ricinus communis
Biochim Biophys Acta, 405 (1), 1-10
DOI 10.1016/0005-2795(75)90308-6, PubMed 1174560 -
Conformation-dependent antigenic determinants in the toxic lectin ricin
J Immunol, 114 (6), 1743-8
PubMed 47877 -
Interactions between ricinus agglutinin and human IgM and IgG
Scand J Immunol, 4 (3), 287-94
DOI 10.1111/j.1365-3083.1975.tb02628.x, PubMed 1080291
Publications 1974
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Lectins from Abrus precatorius and Ricinus communis. II. Hybrid toxins and their interaction with chain-specific antibodies
J Immunol, 113 (3), 842-7
PubMed 4414071 -
Clinical significance of estrogen receptors in human breast cancer
Biomedicine, 20 (6), 377-83
PubMed 4376029 -
Mechanism of action of the toxic lectins abrin and ricin
Nature, 249 (458), 627-31
DOI 10.1038/249627a0, PubMed 4857870 -
Isolation and comparison of galactose-binding lectins from Abrus precatorius and Ricinus communis
J Biol Chem, 249 (3), 803-10
PubMed 4811904 -
Lectins from Abrus precatorius and Ricinus communis. I. Immunochemical relationships between toxins and agglutinins
J Immunol, 113 (3), 835-41
PubMed 4213214 -
On the toxic proteins abrin and ricin. Studies of their binding to and entry into Ehrlich ascites cells
J Biol Chem, 249 (11), 3557-62
PubMed 4208663 -
TOXIC PROTEINS ABRIN AND RICIN - STUDIES OF THEIR BINDING TO AND ENTRY INTO EHRLICH ASCITES-CELLS
J. Biol. Chem., 249 (11), 3557-3562
Publications 1973
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[Gene activation and mRNA synthesis in higher organisms]
Tidsskr Nor Laegeforen, 93 (16), 1230-5
PubMed 4356591 -
[Diphtheria toxin--a specific inhibitor of protein synthesis]
Tidsskr Nor Laegeforen, 93 (4), 223-7
PubMed 4691026 -
Inactivation of eucaryotic ribosomes by the toxic plant proteins abrin and ricin
Mol Biol Rep, 1 (1), 15-20
DOI 10.1007/BF00357400, PubMed 24197425 -
Isolation and properties of abrin: a toxic protein inhibiting protein synthesis. Evidence for different biological functions of its two constituent-peptide chains
Eur J Biochem, 35 (1), 179-85
DOI 10.1111/j.1432-1033.1973.tb02823.x, PubMed 4123356 -
Different biological properties of the two constituent peptide chains of ricin, a toxic protein inhibiting protein synthesis
Biochemistry, 12 (16), 3121-6
DOI 10.1021/bi00740a028, PubMed 4730499 -
Content of estrogen receptors in human breast cancer
Eur J Cancer (1965), 9 (5), 353-7
DOI 10.1016/0014-2964(73)90050-9, PubMed 4355726
Publications 1972
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[Iridocyclitis with juvenile rheumatoid arthritis]
Tidsskr Nor Laegeforen, 12 (13), 922-3
PubMed 5063957 -
Binding of rat liver ribosomes to nuclear complementary RNA
Biochim Biophys Acta, 281 (2), 270-6
DOI 10.1016/0005-2787(72)90179-7, PubMed 4629425 -
Antigenic difference between informofers and protein bound to polyribosomal mRNA from rat liver
Nat New Biol, 240 (98), 90-2
DOI 10.1038/newbio240090a0, PubMed 4117892 -
Toxic proteins inhibiting protein synthesis
Naturwissenschaften, 59 (11), 497-502
DOI 10.1007/BF00609814, PubMed 4657651 -
Deoxycholate-induced release of monosomes from rat liver polyribosomes
Biochim Biophys Acta, 272 (1), 75-80
DOI 10.1016/0005-2787(72)90035-4, PubMed 5043716 -
Inhibition of peptide chain elongation
Nature, 238 (5365), 459-61
DOI 10.1038/238459a0, PubMed 4561855 -
Treatment of abrin and ricin with -mercaptoethanol opposite effects on their toxicity in mice and their ability to inhibit protein synthesis in a cell-free system
FEBS Lett, 28 (1), 48-50
DOI 10.1016/0014-5793(72)80674-4, PubMed 4646874 -
Possible function of the protein bound to nuclear complementary RNA
FEBS Lett, 20 (2), 181-183
DOI 10.1016/0014-5793(72)80788-9, PubMed 11946410 -
Ricin - a potent inhibitor of protein synthesis
FEBS Lett, 20 (3), 327-329
DOI 10.1016/0014-5793(72)80098-x, PubMed 11946449 -
Protein synthesis in the presence of non-ionic detergents in a cell-free system from rabbit reticulocytes
Biochem J, 130 (1), 297-9
DOI 10.1042/bj1300297, PubMed 4655435 -
Translation of mouse globin mRNA by isolated ribosomal subunits from rabbit reticulocytes
Biochim Biophys Acta, 272 (4), 663-6
DOI 10.1016/0005-2787(72)90525-4, PubMed 5050924
Publications 1971
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On the mechanism of the inhibiting effect of aurin tricarboxylic acid on the binding of ribosomes to ribonucleic acids
FEBS Lett, 18 (1), 169-171
DOI 10.1016/0014-5793(71)80436-2, PubMed 11946112 -
Further studies on the protein bound to the messenger RNA in mammalian polysomes
Eur J Biochem, 23 (3), 557-63
DOI 10.1111/j.1432-1033.1971.tb01654.x, PubMed 5003111 -
Evidence that protein is bound to the rapidly labelled RNA in polyribosomes in vivo
Eur J Biochem, 23 (2), 248-52
DOI 10.1111/j.1432-1033.1971.tb01615.x, PubMed 5003205 -
Characterization of the complex containing rapidly labelled RNA in EDTA-treated polyribosomes from rat liver
Eur J Biochem, 18 (2), 242-51
DOI 10.1111/j.1432-1033.1971.tb01237.x, PubMed 5541508 -
The isolation of polysomes from rat liver. Contamination by membrane proteins with high affinity to ribosomes
Biochim Biophys Acta, 232 (4), 705-16
PubMed 5556851
Publications 1970
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Characterization of protein bound to rapidly-labelled RNA in polyribosomes from rat liver
Eur J Biochem, 15 (3), 464-71
DOI 10.1111/j.1432-1033.1970.tb01029.x, PubMed 4989503 -
The isolation of polysomes from rat liver. Contamination of polysomes by ribonucleoprotein of nuclear origin
Biochim Biophys Acta, 213 (1), 149-58
DOI 10.1016/0005-2787(70)90016-x, PubMed 4992322 -
Removal of structural proteins from ribosomes by treatment with sodium deoxycholate in the presence of EDTA
FEBS Lett, 7 (3), 211-213
DOI 10.1016/0014-5793(70)80162-4, PubMed 11947473
Publications 1968
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Amino acid control of RNA synthesis in T4-infected Escherichia coli
Eur J Biochem, 7 (1), 128-36
DOI 10.1111/j.1432-1033.1968.tb19583.x, PubMed 4884582