In a recent paper in Traffic, Lene Malerød, a postdoc in Stenmarks lab, shows that the ESCRT-II complex is required for degradation of ubiquitinated epidermal growth factor receptor and chemokine receptors. This provides new insight into how growth factor and chemokine receptors are transported intracellularly and identifies a novel potential tumour suppressor complex.
Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth
NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
Nat Commun, 10 (1), 5284
The many functions of ESCRTs
Nat Rev Mol Cell Biol, 21 (1), 25-42