In a recent paper in Traffic, Lene Malerød, a postdoc in Stenmarks lab, shows that the ESCRT-II complex is required for degradation of ubiquitinated epidermal growth factor receptor and chemokine receptors. This provides new insight into how growth factor and chemokine receptors are transported intracellularly and identifies a novel potential tumour suppressor complex.
Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon response
EMBO Rep, e50051 (in press)
STEEP mediates STING ER exit and activation of signaling
Nat Immunol, 21 (8), 868-879
Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation
Nat Cell Biol, 22 (7), 856-867