The structure shows how the GLUE domain binds to the hydrophobic patch of ubiquitin and reveals that the ubiquitin- and phosphoinositide-binding sites of the GLUE domains are separate.
Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon response
EMBO Rep, e50051 (in press)
STEEP mediates STING ER exit and activation of signaling
Nat Immunol, 21 (8), 868-879
Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation
Nat Cell Biol, 22 (7), 856-867