Endosomes of fab1 mutants have an expanded size and accumulate the signalling molecules Notch, Wingless and Dpp. The signalling of these molecules is nevertheless normal. The results suggest that Fab1 controls late stages of endocytic trafficking at a point when signal termination has occurred. The mechanism by which Fab1 regulates growth remains a subject for further research.
Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth
NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
Nat Commun, 10 (1), 5284
The many functions of ESCRTs
Nat Rev Mol Cell Biol, 21 (1), 25-42