PhD student Antonia Sagona and her co-workers in Harald Stenmark's group have uncovered a new functional mechanism for a known tumour suppressor, class III phosphoinositide 3-kinase. The article was published in the April 2010 issue of Nature Cell Biology.
Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon response
EMBO Rep, e50051 (in press)
STEEP mediates STING ER exit and activation of signaling
Nat Immunol, 21 (8), 868-879
Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation
Nat Cell Biol, 22 (7), 856-867