Publications 2024

Duran J, Salinas JE, Wheaton RP, Poolsup S, Allers L, Rosas-Lemus M, Chen L, Cheng Q, Pu J, Salemi M, Phinney B, Ivanov P, Lystad AH, Bhaskar K, Rajaiya J, Perkins DJ, Jia J (2024)
Calcium signaling from damaged lysosomes induces cytoprotective stress granules
EMBO J (in press)
DOI 10.1038/s44318-024-00292-1, PubMed 39533058

Publications 2023

Kaur N, Carlsson SR, Lystad AH (2023)
The separate axes of TECPR1 and ATG16L1 in CASM
Autophagy, 20 (1), 214-215
DOI 10.1080/15548627.2023.2255462, PubMed 37676042

Kaur N, de la Ballina LR, Haukaas HS, Torgersen ML, Radulovic M, Munson MJ, Sabirsh A, Stenmark H, Simonsen A, Carlsson SR, Lystad AH (2023)
TECPR1 is activated by damage-induced sphingomyelin exposure to mediate noncanonical autophagy
EMBO J, 42 (17), e113105
DOI 10.15252/embj.2022113105, PubMed 37409525

Publications 2022

Radulovic M, Wenzel EM, Gilani S, Holland LK, Lystad AH, Phuyal S, Olkkonen VM, Brech A, Jäättelä M, Maeda K, Raiborg C, Stenmark H (2022)
Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair
EMBO J, 41 (24), e112677
DOI 10.15252/embj.2022112677, PubMed 36408828

Søreng K, Pankiv S, Bergsmark C, Haugsten EM, Dahl AK, de la Ballina LR, Yamamoto A, Lystad AH, Simonsen A (2022)
ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration
J Cell Sci, 135 (4)
DOI 10.1242/jcs.259138, PubMed 35099014

Xu J, Yang KC, Go NE, Colborne S, Ho CJ, Hosseini-Beheshti E, Lystad AH, Simonsen A, Guns ET, Morin GB, Gorski SM (2022)
Chloroquine treatment induces secretion of autophagy-related proteins and inclusion of Atg8-family proteins in distinct extracellular vesicle populations
Autophagy, 18 (11), 2547-2560
DOI 10.1080/15548627.2022.2039535, PubMed 35220892

Publications 2021

Corkery DP, Nadeem A, Aung KM, Hassan A, Liu T, Cervantes-Rivera R, Lystad AH, Wang H, Persson K, Puhar A, Simonsen A, Uhlin BE, Wai SN, Wu YW (2021)
Vibrio cholerae cytotoxin MakA induces noncanonical autophagy resulting in the spatial inhibition of canonical autophagy
J Cell Sci, 134 (5)
DOI 10.1242/jcs.252015, PubMed 33106317

Durgan J, Lystad AH, Sloan K, Carlsson SR, Wilson MI, Marcassa E, Ulferts R, Webster J, Lopez-Clavijo AF, Wakelam MJ, Beale R, Simonsen A, Oxley D, Florey O (2021)
Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine
Mol Cell, 81 (9), 2031-2040.e8
DOI 10.1016/j.molcel.2021.03.020, PubMed 33909989

Giovannucci TA, Salomons FA, Stoy H, Herzog LK, Xu S, Qian W, Merino LG, Gierisch ME, Haraldsson M, Lystad AH, Uvell H, Simonsen A, Gustavsson AL, Vallin M, Dantuma NP (2021)
Identification of a novel compound that simultaneously impairs the ubiquitin-proteasome system and autophagy
Autophagy, 18 (7), 1486-1502
DOI 10.1080/15548627.2021.1988359, PubMed 34740308

Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM et al. (2021)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹
Autophagy, 17 (1), 1-382
DOI 10.1080/15548627.2020.1797280, PubMed 33634751

Kumar S, Javed R, Mudd M, Pallikkuth S, Lidke KA, Jain A, Tangavelou K, Gudmundsson SR, Ye C, Rusten TE, Anonsen JH, Lystad AH, Claude-Taupin A, Simonsen A, Salemi M, Phinney B, Li J, Guo LW, Bradfute SB, Timmins GS, Eskelinen EL, Deretic V (2021)
Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes
Cell, 184 (24), 5950-5969.e22
DOI 10.1016/j.cell.2021.10.017, PubMed 34741801

Munson MJ, Mathai BJ, Ng MYW, Trachsel-Moncho L, de la Ballina LR, Schultz SW, Aman Y, Lystad AH, Singh S, Singh S, Wesche J, Fang EF, Simonsen A (2021)
GAK and PRKCD are positive regulators of PRKN-independent mitophagy
Nat Commun, 12 (1), 6101
DOI 10.1038/s41467-021-26331-7, PubMed 34671015

Publications 2020

Hamaoui D, Cossé MM, Mohan J, Lystad AH, Wollert T, Subtil A (2020)
The Chlamydia effector CT622/TaiP targets a nonautophagy related function of ATG16L1
Proc Natl Acad Sci U S A, 117 (43), 26784-26794
DOI 10.1073/pnas.2005389117, PubMed 33055216

Melia TJ, Lystad AH, Simonsen A (2020)
Autophagosome biogenesis: From membrane growth to closure
J Cell Biol, 219 (6)
DOI 10.1083/jcb.202002085, PubMed 32357219

Publications 2019

Herhaus L, Bhaskara RM, Lystad AH, Gestal-Mato U, Covarrubias-Pinto A, Bonn F, Simonsen A, Hummer G, Dikic I (2019)
TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease
EMBO Rep, 21 (1), e48317
DOI 10.15252/embr.201948317, PubMed 31709703

Herzog LK, Kevei É, Marchante R, Böttcher C, Bindesbøll C, Lystad AH, Pfeiffer A, Gierisch ME, Salomons FA, Simonsen A, Hoppe T, Dantuma NP (2019)
The Machado-Joseph disease deubiquitylase ataxin-3 interacts with LC3C/GABARAP and promotes autophagy
Aging Cell, 19 (1), e13051
DOI 10.1111/acel.13051, PubMed 31625269

Lystad AH, Carlsson SR, de la Ballina LR, Kauffman KJ, Nag S, Yoshimori T, Melia TJ, Simonsen A (2019)
Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes
Nat Cell Biol, 21 (3), 372-383
DOI 10.1038/s41556-019-0274-9, PubMed 30778222

Lystad AH, Carlsson SR, Simonsen A (2019)
Toward the function of mammalian ATG12-ATG5-ATG16L1 complex in autophagy and related processes
Autophagy, 15 (8), 1485-1486
DOI 10.1080/15548627.2019.1618100, PubMed 31122169

Lystad AH, Simonsen A (2019)
Mechanisms and Pathophysiological Roles of the ATG8 Conjugation Machinery
Cells, 8 (9)
DOI 10.3390/cells8090973, PubMed 31450711

Publications 2018

Kauffman KJ, Yu S, Jin J, Mugo B, Nguyen N, O'Brien A, Nag S, Lystad AH, Melia TJ (2018)
Delipidation of mammalian Atg8-family proteins by each of the four ATG4 proteases
Autophagy, 14 (6), 992-1010
DOI 10.1080/15548627.2018.1437341, PubMed 29458288

Publications 2016

Dragich JM, Kuwajima T, Hirose-Ikeda M, Yoon MS, Eenjes E, Bosco JR, Fox LM, Lystad AH, Oo TF, Yarygina O, Mita T, Waguri S, Ichimura Y, Komatsu M, Simonsen A, Burke RE, Mason CA, Yamamoto A (2016)
Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain
Elife, 5
DOI 10.7554/eLife.14810, PubMed 27648578

Holland P, Knævelsrud H, Søreng K, Mathai BJ, Lystad AH, Pankiv S, Bjørndal GT, Schultz SW, Lobert VH, Chan RB, Zhou B, Liestøl K, Carlsson SR, Melia TJ, Di Paolo G, Simonsen A (2016)
HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels
Nat Commun, 7, 13889
DOI 10.1038/ncomms13889, PubMed 28004827

Lystad AH, Simonsen A (2016)
Phosphoinositide-binding proteins in autophagy
FEBS Lett, 590 (15), 2454-68
DOI 10.1002/1873-3468.12286, PubMed 27391591

Publications 2014

Lystad AH, Ichimura Y, Takagi K, Yang Y, Pankiv S, Kanegae Y, Kageyama S, Suzuki M, Saito I, Mizushima T, Komatsu M, Simonsen A (2014)
Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures
EMBO Rep, 15 (5), 557-65
DOI 10.1002/embr.201338003, PubMed 24668264

Lystad AH, Simonsen A (2014)
Assays to monitor aggrephagy
Methods, 75, 112-9
DOI 10.1016/j.ymeth.2014.12.019, PubMed 25555675

Publications 2013

Isakson P, Lystad AH, Breen K, Koster G, Stenmark H, Simonsen A (2013)
TRAF6 mediates ubiquitination of KIF23/MKLP1 and is required for midbody ring degradation by selective autophagy
Autophagy, 9 (12), 1955-64
DOI 10.4161/auto.26085, PubMed 24128730