Tore Skotland

  • Emeritus scientist
  • +47 22 78 18 26


Publications 2024

Skotland T, Ekroos K, McDonald J, Ahrends R, Liebisch G, Sandvig K (2024)
Pitfalls in lipid mass spectrometry of mammalian samples - a brief guide for biologists
Nat Rev Mol Cell Biol (in press)
DOI 10.1038/s41580-024-00758-4, PubMed 38951702

Valsalakumari R, Pandya AD, Prasmickaite L, Kvalvaag A, Myrann AG, Åslund AKO, Kjos MS, Fontecha-Cuenca C, Haroon HB, Ribeiro ARS, Horejs-Hoeck J, Moghimi SM, Mørch Ý, Skotland T, Sandvig K, Mælandsmo GM, Iversen TG (2024)
Preclinical Efficacy of Cabazitaxel Loaded Poly(2-alkyl cyanoacrylate) Nanoparticle Variants
Int J Nanomedicine, 19, 3009-3029
DOI 10.2147/IJN.S450283, PubMed 38562610

Publications 2023

Skotland T, Llorente A, Sandvig K (2023)
Lipids in Extracellular Vesicles: What Can Be Learned about Membrane Structure and Function?
Cold Spring Harb Perspect Biol, 15 (8)
DOI 10.1101/cshperspect.a041415, PubMed 37277192

Publications 2022

Fusser M, Øverbye A, Pandya AD, Mørch Ý, Borgos SE, Kildal W, Snipstad S, Sulheim E, Fleten KG, Askautrud HA, Engebraaten O, Flatmark K, Iversen TG, Sandvig K, Skotland T, Mælandsmo GM (2022)
Corrigendum to "Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft", [Journal of Control Release, 293 (2019) 183-192]
J Control Release, 349, 1
DOI 10.1016/j.jconrel.2022.06.040, PubMed 35792388

Nissen-Meyer J, Skotland T, Boye E (2022)
Are doping tests in sports trustworthy?: Athletes suffer from insufficiently defined criteria for doping tests: Athletes suffer from insufficiently defined criteria for doping tests
EMBO Rep, 23 (3), e54431
DOI 10.15252/embr.202154431, PubMed 35156749

Sandvig K, Kavaliauskiene S, Myrann AG, Iversen TG, Skotland T (2022)
Modulation of Ricin Intoxication by the Autophagy Inhibitor EACC
Toxins (Basel), 14 (5)
DOI 10.3390/toxins14050360, PubMed 35622606

Skotland T, Iversen TG, Llorente A, Sandvig K (2022)
Biodistribution, pharmacokinetics and excretion studies of intravenously injected nanoparticles and extracellular vesicles: Possibilities and challenges
Adv Drug Deliv Rev, 186, 114326
DOI 10.1016/j.addr.2022.114326, PubMed 35588953

Skotland T, Sandvig K (2022)
Need for more focus on lipid species in studies of biological and model membranes
Prog Lipid Res, 86, 101160
DOI 10.1016/j.plipres.2022.101160, PubMed 35288150

Publications 2021

Pandya AD, Iversen TG, Moestue S, Grinde MT, Mørch Ý, Snipstad S, Åslund AKO, Øy GF, Kildal W, Engebråten O, Sandvig K, Skotland T, Mælandsmo GM (2021)
Biodistribution of Poly(alkyl cyanoacrylate) Nanoparticles in Mice and Effect on Tumor Infiltration of Macrophages into a Patient-Derived Breast Cancer Xenograft
Nanomaterials (Basel), 11 (5)
DOI 10.3390/nano11051140, PubMed 33924869

Sandvig K, Kavaliauskiene S, Skotland T (2021)
The Protein Toxins Ricin and Shiga Toxin as Tools to Explore Cellular Mechanisms of Internalization and Intracellular Transport
Toxins (Basel), 13 (6)
DOI 10.3390/toxins13060377, PubMed 34070659

Skotland T, Iversen TG, Sandvig K (2021)
Cellular uptake of nanoparticles: Involvement of caveolae?
Precis Nanomed, 4 (2), 782-786
DOI 10.33218/001c.22201, PublikaID 365

Skotland T, Sandvig K (2021)
Transport of nanoparticles across the endothelial cell layer
Nano Today, 36, 101029
DOI 10.1016/j.nantod.2020.101029

Valsalakumari R, Yadava SK, Szwed M, Pandya AD, Mælandsmo GM, Torgersen ML, Iversen TG, Skotland T, Sandvig K, Giri J (2021)
Mechanism of cellular uptake and cytotoxicity of paclitaxel loaded lipid nanocapsules in breast cancer cells
Int J Pharm, 597, 120217
DOI 10.1016/j.ijpharm.2021.120217, PubMed 33486035

Øverbye A, Torgersen ML, Sønstevold T, Iversen TG, Mørch Ý, Skotland T, Sandvig K (2021)
Cabazitaxel-loaded poly(alkyl cyanoacrylate) nanoparticles: toxicity and changes in the proteome of breast, colon and prostate cancer cells
Nanotoxicology, 15 (7), 865-884
DOI 10.1080/17435390.2021.1924888, PubMed 34047629

Publications 2020

Lingelem ABD, Kavaliauskiene S, Halsne R, Klokk TI, Surma MA, Klose C, Skotland T, Sandvig K (2020)
Diacylglycerol kinase and phospholipase D inhibitors alter the cellular lipidome and endosomal sorting towards the Golgi apparatus
Cell Mol Life Sci, 78 (3), 985-1009
DOI 10.1007/s00018-020-03551-6, PubMed 32447426

Pandya AD, Øverbye A, Sahariah P, Gaware VS, Høgset H, Masson M, Høgset A, Mælandsmo GM, Skotland T, Sandvig K, Iversen TG (2020)
Drug-Loaded Photosensitizer-Chitosan Nanoparticles for Combinatorial Chemo- and Photodynamic-Therapy of Cancer
Biomacromolecules, 21 (4), 1489-1498
DOI 10.1021/acs.biomac.0c00061, PubMed 32092254

Skotland T, Kavaliauskiene S, Sandvig K (2020)
The role of lipid species in membranes and cancer-related changes
Cancer Metastasis Rev, 39 (2), 343-360
DOI 10.1007/s10555-020-09872-z, PubMed 32314087

Skotland T, Sagini K, Sandvig K, Llorente A (2020)
An emerging focus on lipids in extracellular vesicles
Adv Drug Deliv Rev, 159, 308-321
DOI 10.1016/j.addr.2020.03.002, PubMed 32151658

Szwed M, Torgersen ML, Kumari RV, Yadava SK, Pust S, Iversen TG, Skotland T, Giri J, Sandvig K (2020)
Biological response and cytotoxicity induced by lipid nanocapsules
J Nanobiotechnology, 18 (1), 5
DOI 10.1186/s12951-019-0567-y, PubMed 31907052

Sønstevold T, Engedal N, Mørch Ý, Iversen TG, Skotland T, Sandvig K, Torgersen ML (2020)
Structural Variants of poly(alkylcyanoacrylate) Nanoparticles Differentially Affect LC3 and Autophagic Cargo Degradation
J Biomed Nanotechnol, 16 (4), 432-445
DOI 10.1166/jbn.2020.2906, PubMed 32970976

Torgersen ML, Judge PJ, Bada Juarez JF, Pandya AD, Fusser M, Davies CW, Maciejewska MK, Yin DJ, Maelandsmo GM, Skotland T, Watts A, Sandvig K (2020)
Physicochemical Characterization, Toxicity and In Vivo Biodistribution Studies of a Discoidal, Lipid-Based Drug Delivery Vehicle: Lipodisq Nanoparticles Containing Doxorubicin
J Biomed Nanotechnol, 16 (4), 419-431
DOI 10.1166/jbn.2020.2911, PubMed 32970975

Tsjokajev A, Røberg-Larsen H, Wilson SR, Dyve Lingelem AB, Skotland T, Sandvig K, Lundanes E (2020)
Mass spectrometry-based measurements of cyclic adenosine monophosphate in cells, simplified using reversed phase liquid chromatography with a polar characterized stationary phase
J Chromatogr B Analyt Technol Biomed Life Sci, 1160, 122384
DOI 10.1016/j.jchromb.2020.122384, PubMed 32971370

Publications 2019

Moghimi SM, Simberg D, Skotland T, Yaghmur A, Hunter AC (2019)
The Interplay Between Blood Proteins, Complement, and Macrophages on Nanomedicine Performance and Responses
J Pharmacol Exp Ther, 370 (3), 581-592
DOI 10.1124/jpet.119.258012, PubMed 30940695

Nissen-Meyer J, Skotland T, Østerud B, Boye E (2019)
Improving scientific practice in sports-associated drug testing
FEBS J, 286 (14), 2664-2669
DOI 10.1111/febs.14920, PubMed 31095893

Pandya AD, Jäger E, Bagheri Fam S, Höcherl A, Jäger A, Sincari V, Nyström B, Štěpánek P, Skotland T, Sandvig K, Hrubý M, Mælandsmo GM (2019)
Paclitaxel-loaded biodegradable ROS-sensitive nanoparticles for cancer therapy
Int J Nanomedicine, 14, 6269-6285
DOI 10.2147/IJN.S208938, PubMed 31496685

Skotland T, Sandvig K (2019)
The role of PS 18:0/18:1 in membrane function
Nat Commun, 10 (1), 2752
DOI 10.1038/s41467-019-10711-1, PubMed 31227693

Szwed M, Sønstevold T, Øverbye A, Engedal N, Grallert B, Mørch Ý, Sulheim E, Iversen TG, Skotland T, Sandvig K, Torgersen ML (2019)
Small variations in nanoparticle structure dictate differential cellular stress responses and mode of cell death
Nanotoxicology, 13 (6), 761-782
DOI 10.1080/17435390.2019.1576238, PubMed 30760074

Publications 2018

Fusser M, Øverbye A, Pandya AD, Mørch Ý, Borgos SE, Kildal W, Snipstad S, Sulheim E, Fleten KG, Askautrud HA, Engebraaten O, Flatmark K, Iversen TG, Sandvig K, Skotland T, Mælandsmo GM (2018)
Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft
J Control Release, 293, 183-192
DOI 10.1016/j.jconrel.2018.11.029, PubMed 30529259

Sandvig K, Kavaliauskiene S, Skotland T (2018)
Clathrin-independent endocytosis: an increasing degree of complexity
Histochem Cell Biol, 150 (2), 107-118
DOI 10.1007/s00418-018-1678-5, PubMed 29774430

Skotland T, Hessvik NP, Sandvig K, Llorente A (2018)
Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology
J Lipid Res, 60 (1), 9-18
DOI 10.1194/jlr.R084343, PubMed 30076207

Publications 2017

Ailte I, Lingelem AB, Kvalvaag AS, Kavaliauskiene S, Brech A, Koster G, Dommersnes PG, Bergan J, Skotland T, Sandvig K (2017)
Exogenous lysophospholipids with large head groups perturb clathrin-mediated endocytosis
Traffic, 18 (3), 176-191
DOI 10.1111/tra.12468, PubMed 28067430

Boye E, Skotland T, Østerud B, Nissen-Meyer J (2017)
Doping and drug testing: Anti-doping work must be transparent and adhere to good scientific practices to ensure public trust
EMBO Rep, 18 (3), 351-354
DOI 10.15252/embr.201643540, PubMed 28167676

Kavaliauskiene S, Dyve Lingelem AB, Skotland T, Sandvig K (2017)
Protection against Shiga Toxins
Toxins (Basel), 9 (2)
DOI 10.3390/toxins9020044, PubMed 28165371

Skotland T (2017)
Injection of nanoparticles into cloven-hoof animals: Asking for trouble
Theranostics, 7 (19), 4877-4878
DOI 10.7150/thno.22420, PubMed 29187910

Skotland T, Sandvig K, Llorente A (2017)
Lipids in exosomes: Current knowledge and the way forward
Prog Lipid Res, 66, 30-41
DOI 10.1016/j.plipres.2017.03.001, PubMed 28342835

Sulheim E, Iversen TG, To Nakstad V, Klinkenberg G, Sletta H, Schmid R, Hatletveit AR, Wågbø AM, Sundan A, Skotland T, Sandvig K, Mørch Ý (2017)
Cytotoxicity of Poly(Alkyl Cyanoacrylate) Nanoparticles
Int J Mol Sci, 18 (11)
DOI 10.3390/ijms18112454, PubMed 29156588

Vestad B, Llorente A, Neurauter A, Phuyal S, Kierulf B, Kierulf P, Skotland T, Sandvig K, Haug KBF, Øvstebø R (2017)
Size and concentration analyses of extracellular vesicles by nanoparticle tracking analysis: a variation study
J Extracell Vesicles, 6 (1), 1344087
DOI 10.1080/20013078.2017.1344087, PubMed 28804597

Øverbye A, Holsæter AM, Markus F, Škalko-Basnet N, Iversen TG, Torgersen ML, Sønstevold T, Engebraaten O, Flatmark K, Mælandsmo GM, Skotland T, Sandvig K (2017)
Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide
Oncotarget, 8 (44), 76921-76934
DOI 10.18632/oncotarget.20217, PubMed 29100358

Publications 2016

Ailte I, Lingelem AB, Kavaliauskiene S, Bergan J, Kvalvaag AS, Myrann AG, Skotland T, Sandvig K (2016)
Addition of lysophospholipids with large head groups to cells inhibits Shiga toxin binding
Sci Rep, 6, 30336
DOI 10.1038/srep30336, PubMed 27458147

Kavaliauskiene S, Torgersen ML, Lingelem AB, Klokk TI, Lintonen T, Simolin H, Ekroos K, Skotland T, Sandvig K (2016)
Cellular effects of fluorodeoxyglucose: Global changes in the lipidome and alteration in intracellular transport
Oncotarget, 7 (48), 79885-79900
DOI 10.18632/oncotarget.13089, PubMed 27829218

Róg T, Orłowski A, Llorente A, Skotland T, Sylvänne T, Kauhanen D, Ekroos K, Sandvig K, Vattulainen I (2016)
Data including GROMACS input files for atomistic molecular dynamics simulations of mixed, asymmetric bilayers including molecular topologies, equilibrated structures, and force field for lipids compatible with OPLS-AA parameters
Data Brief, 7, 1171-1174
DOI 10.1016/j.dib.2016.03.067, PubMed 27761499

Skotland T (2016)
How organizers of scientific meetings and journal editors could facilitate transfer of nanomedicine into the clinic
Eur. J. Nanomed., 8 (1), 61-63
DOI 10.1515/ejnm-2015-0048

Skotland T, Ekroos K, Kauhanen D, Simolin H, Seierstad T, Berge V, Sandvig K, Llorente A (2016)
Molecular lipid species in urinary exosomes as potential prostate cancer biomarkers
Eur J Cancer, 70, 122-132
DOI 10.1016/j.ejca.2016.10.011, PubMed 27914242

Skotland T, Ekroos K, Kavaliauskiene S, Bergan J, Kauhanen D, Lintonen T, Sandvig K (2016)
Determining the Turnover of Glycosphingolipid Species by Stable-Isotope Tracer Lipidomics
J Mol Biol, 428 (24 Pt A), 4856-4866
DOI 10.1016/j.jmb.2016.06.013, PubMed 27363608

Torgersen ML, Klokk TI, Kavaliauskiene S, Klose C, Simons K, Skotland T, Sandvig K (2016)
The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport
Oncotarget, 7 (52), 86871-86888
DOI 10.18632/oncotarget.13508, PubMed 27894086

Wang L, Skotland T, Berge V, Sandvig K, Llorente A (2016)
Exosomal proteins as prostate cancer biomarkers in urine: From mass spectrometry discovery to immunoassay-based validation
Eur J Pharm Sci, 98, 80-85
DOI 10.1016/j.ejps.2016.09.023, PubMed 27664330

Publications 2015

Kavaliauskiene S, Skotland T, Sylvänne T, Simolin H, Klokk TI, Torgersen ML, Lingelem AB, Simm R, Ekroos K, Sandvig K (2015)
Novel actions of 2-deoxy-D-glucose: protection against Shiga toxins and changes in cellular lipids
Biochem J, 470 (1), 23-37
DOI 10.1042/BJ20141562, PubMed 26251444

Kymre L, Simm R, Skotland T, Sandvig K (2015)
Different roles of the C-terminal end of Stx1A and Stx2A for AB5 complex integrity and retrograde transport of Stx in HeLa cells
Pathog Dis, 73 (9), ftv083
DOI 10.1093/femspd/ftv083, PubMed 26443836

Róg T, Orłowski A, Llorente A, Skotland T, Sylvänne T, Kauhanen D, Ekroos K, Sandvig K, Vattulainen I (2015)
Interdigitation of long-chain sphingomyelin induces coupling of membrane leaflets in a cholesterol dependent manner
Biochim Biophys Acta, 1858 (2), 281-8
DOI 10.1016/j.bbamem.2015.12.003, PubMed 26654782

Skotland T, Iversen TG, Torgersen ML, Sandvig K (2015)
Cell-penetrating peptides: possibilities and challenges for drug delivery in vitro and in vivo
Molecules, 20 (7), 13313-23
DOI 10.3390/molecules200713313, PubMed 26205056

Øverbye A, Skotland T, Koehler CJ, Thiede B, Seierstad T, Berge V, Sandvig K, Llorente A (2015)
Identification of prostate cancer biomarkers in urinary exosomes
Oncotarget, 6 (30), 30357-76
DOI 10.18632/oncotarget.4851, PubMed 26196085

Publications 2014

Bergan J, Skotland T, Lingelem AB, Simm R, Spilsberg B, Lindbäck T, Sylvänne T, Simolin H, Ekroos K, Sandvig K (2014)
The ether lipid precursor hexadecylglycerol protects against Shiga toxins
Cell Mol Life Sci, 71 (21), 4285-300
DOI 10.1007/s00018-014-1624-1, PubMed 24740796

Phuyal S, Hessvik NP, Skotland T, Sandvig K, Llorente A (2014)
Regulation of exosome release by glycosphingolipids and flotillins
FEBS J, 281 (9), 2214-27
DOI 10.1111/febs.12775, PubMed 24605801

Phuyal S, Skotland T, Hessvik NP, Simolin H, Øverbye A, Brech A, Parton RG, Ekroos K, Sandvig K, Llorente A (2014)
The ether lipid precursor hexadecylglycerol stimulates the release and changes the composition of exosomes derived from PC-3 cells
J Biol Chem, 290 (7), 4225-37
DOI 10.1074/jbc.M114.593962, PubMed 25519911

Sandvig K, Bergan J, Kavaliauskiene S, Skotland T (2014)
Lipid requirements for entry of protein toxins into cells
Prog Lipid Res, 54, 1-13
DOI 10.1016/j.plipres.2014.01.001, PubMed 24462587

Skotland T, Iversen TG, Sandvig K (2014)
Development of nanoparticles for clinical use
Nanomedicine (Lond), 9 (9), 1295-9
DOI 10.2217/nnm.14.81, PubMed 25204821

Publications 2013

Bergan J, Skotland T, Sylvänne T, Simolin H, Ekroos K, Sandvig K (2013)
The ether lipid precursor hexadecylglycerol causes major changes in the lipidome of HEp-2 cells
PLoS One, 8 (9), e75904
DOI 10.1371/journal.pone.0075904, PubMed 24098742

Kavaliauskiene S, Nymark CM, Bergan J, Simm R, Sylvänne T, Simolin H, Ekroos K, Skotland T, Sandvig K (2013)
Cell density-induced changes in lipid composition and intracellular trafficking
Cell Mol Life Sci, 71 (6), 1097-116
DOI 10.1007/s00018-013-1441-y, PubMed 23921715

Llorente A, Skotland T, Sylvänne T, Kauhanen D, Róg T, Orłowski A, Vattulainen I, Ekroos K, Sandvig K (2013)
Molecular lipidomics of exosomes released by PC-3 prostate cancer cells
Biochim Biophys Acta, 1831 (7), 1302-9
DOI 10.1016/j.bbalip.2013.04.011, PubMed 24046871

Sandvig K, Skotland T, van Deurs B, Klokk TI (2013)
Retrograde transport of protein toxins through the Golgi apparatus
Histochem Cell Biol, 140 (3), 317-26
DOI 10.1007/s00418-013-1111-z, PubMed 23765164

Publications 2012

Bergan J, Dyve Lingelem AB, Simm R, Skotland T, Sandvig K (2012)
Shiga toxins
Toxicon, 60 (6), 1085-107
DOI 10.1016/j.toxicon.2012.07.016, PubMed 22960449

Skotland T (2012)
Molecular imaging: challenges of bringing imaging of intracellular targets into common clinical use
Contrast Media Mol Imaging, 7 (1), 1-6
DOI 10.1002/cmmi.458, PubMed 22344874

Østerud B, Skotland T (2012)
Doping analyses are not on safe ground
Tidsskr Nor Laegeforen, 132 (8), 929-30
DOI 10.4045/tidsskr.12.0252, PubMed 22562317

Publications 2011

Engedal N, Skotland T, Torgersen ML, Sandvig K (2011)
Shiga toxin and its use in targeted cancer therapy and imaging
Microb Biotechnol, 4 (1), 32-46
DOI 10.1111/j.1751-7915.2010.00180.x, PubMed 21255370

Iversen TG, Skotland T, Sandvig K (2011)
Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies
Nano Today, 6 (2), 176-185
DOI 10.1016/j.nantod.2011.02.003

Sandvig K, Pust S, Skotland T, van Deurs B (2011)
Clathrin-independent endocytosis: mechanisms and function
Curr Opin Cell Biol, 23 (4), 413-20
DOI 10.1016/, PubMed 21466956

Skotland T, Iversen TG, Sandvig K (2011)
Comment on "short ligands affect modes of QD uptake and elimination in human cells"
ACS Nano, 5 (10), 7690; author reply 7691-2
DOI 10.1021/nn2021953, PubMed 22023400

Publications 2010

Christiansen C, Skotland T (2010)
Changes of protein solutions during storage: a study of albumin pharmaceutical preparations
Biotechnol Appl Biochem, 55 (3), 121-30
DOI 10.1042/BA20090239, PubMed 20121704

Kindberg GM, Uran S, Friisk G, Martinsen I, Skotland T (2010)
The fate of Gd and chelate following intravenous injection of gadodiamide in rats
Eur Radiol, 20 (7), 1636-43
DOI 10.1007/s00330-010-1716-8, PubMed 20157815

Sandvig K, Torgersen ML, Engedal N, Skotland T, Iversen TG (2010)
Protein toxins from plants and bacteria: probes for intracellular transport and tools in medicine
FEBS Lett, 584 (12), 2626-34
DOI 10.1016/j.febslet.2010.04.008, PubMed 20385131

Skotland T, Iversen TG, Sandvig K (2010)
New metal-based nanoparticles for intravenous use: requirements for clinical success with focus on medical imaging
Nanomedicine, 6 (6), 730-7
DOI 10.1016/j.nano.2010.05.002, PubMed 20570639

Publications 2009

Moestue S, Nunez P, Healey A, Bjerke R, Indrevoll B, Skotland T, Hustvedt SO (2009)
Whole-body section fluorescence imaging--a novel method for tissue distribution studies of fluorescent substances
Contrast Media Mol Imaging, 4 (2), 73-80
DOI 10.1002/cmmi.264, PubMed 19142979

Roed L, Oulie I, McParland BJ, Skotland T (2009)
Human urinary excretion of NC100692, an RGD-peptide for imaging angiogenesis
Eur J Pharm Sci, 37 (3-4), 279-83
DOI 10.1016/j.ejps.2009.02.017, PubMed 19491016

Raa H, Grimmer S, Schwudke D, Bergan J, Wälchli S, Skotland T, Shevchenko A, Sandvig K (2009)
Glycosphingolipid requirements for endosome-to-Golgi transport of Shiga toxin
Traffic, 10 (7), 868-82
DOI 10.1111/j.1600-0854.2009.00919.x, PubMed 19453975

Sandvig K, Bergan J, Dyve AB, Skotland T, Torgersen ML (2009)
Endocytosis and retrograde transport of Shiga toxin
Toxicon, 56 (7), 1181-5
DOI 10.1016/j.toxicon.2009.11.021, PubMed 19951719

Publications 2007

Landmark KE, Johansen PW, Johnson JA, Johansen B, Uran S, Skotland T (2007)
Pharmacokinetics of perfluorobutane following intravenous bolus injection and continuous infusion of sonazoid in healthy volunteers and in patients with reduced pulmonary diffusing capacity
Ultrasound Med Biol, 34 (3), 494-501
DOI 10.1016/j.ultrasmedbio.2007.09.019, PubMed 18096304

Oulie I, Roed L, Toft KG, Skotland T (2007)
Quantification of NC100692, a new tracer for 99mTc-imaging of angiogenesis, in human plasma using reversed-phase liquid chromatography coupled with electrospray ionization ion-trap mass spectrometry
J Chromatogr B Analyt Technol Biomed Life Sci, 852 (1-2), 605-10
DOI 10.1016/j.jchromb.2007.02.039, PubMed 17353156

Roed L, Oulie I, Knüttel T, Toft KG, Hustvedt SO, Skotland T (2007)
Metabolism in rats of NC100692, an RGD-peptide for imaging of angiogenesis
J Pharm Biomed Anal, 47 (1), 164-9
DOI 10.1016/j.jpba.2007.12.026, PubMed 18242918

Toft KG, Johnson JA, Oulie I, Skotland T (2007)
NC100668, a new tracer tested for imaging of venous thromboembolism: pharmacokinetics and metabolism in humans
Drug Metab Dispos, 35 (11), 1979-84
DOI 10.1124/dmd.106.014126, PubMed 17682073

Uran S, Landmark KE, Hjellum G, Skotland T (2007)
Quantification of 13C pyruvate and 13C lactate in dog blood by reversed-phase liquid chromatography-electrospray ionization mass spectrometry after derivatization with 3-nitrophenylhydrazine
J Pharm Biomed Anal, 44 (4), 947-54
DOI 10.1016/j.jpba.2007.04.001, PubMed 17482415

Publications 2006

Hvattum E, Uran S, Sandbaek AG, Karlsson AA, Skotland T (2006)
Quantification of phosphatidylserine, phosphatidic acid and free fatty acids in an ultrasound contrast agent by normal-phase high-performance liquid chromatography with evaporative light scattering detection
J Pharm Biomed Anal, 42 (4), 506-12
DOI 10.1016/j.jpba.2006.04.027, PubMed 16762523

Skotland T, Grant D (2006)
In vitro cytotoxic effects of iodinated contrast media on a renal tubular cell line
Radiology, 238 (2), 758-9; author reply 759-60
DOI 10.1148/radiol.2382050933, PubMed 16436833

Skotland T, Sontum PC, Christiansen C (2006)
Absence of large molecular aggregates in X-ray contrast media
Eur Radiol, 17 (5), 1377-9
DOI 10.1007/s00330-006-0390-3, PubMed 16951928

Toft KG, Hustvedt SO, Hals PA, Oulie I, Uran S, Landmark K, Normann PT, Skotland T (2006)
Disposition of perfluorobutane in rats after intravenous injection of Sonazoid
Ultrasound Med Biol, 32 (1), 107-14
DOI 10.1016/j.ultrasmedbio.2005.09.008, PubMed 16364802

Publications 2005

Skotland T, Hustvedt SO, Oulie I, Jacobsen PB, Friisk GA, Langøy AS, Uran S, Sandosham J, Cuthbertson A, Toft KG (2005)
Nc100668, a new tracer for imaging of venous thromboembolism: disposition and metabolism in rats
Drug Metab Dispos, 34 (1), 111-20
DOI 10.1124/dmd.105.006239, PubMed 16251253

Toft KG, Oulie I, Skotland T (2005)
Quantification of NC100668, a new tracer for imaging of venous thromboembolism, in human plasma using reversed-phase liquid chromatography coupled with electrospray ionization ion-trap mass spectrometry
J Chromatogr B Analyt Technol Biomed Life Sci, 829 (1-2), 91-6
DOI 10.1016/j.jchromb.2005.09.031, PubMed 16219494

Uran S, Landmark K, Normann PT, Hals PA, Toft KG, Skotland T (2005)
A respiration-metabolism chamber system and a GC-MS method developed for studying exhalation of perfluorobutane in rats after intravenous injection of the ultrasound contrast agent Sonazoid
J Pharm Biomed Anal, 39 (3-4), 746-51
DOI 10.1016/j.jpba.2005.04.038, PubMed 15964732

Publications 2004

Skotland T (2004)
Contrast media augmented apoptosis of cultured renal mesangial, tubular, epithelial, and hepatic cells
Invest Radiol, 39 (9), 582; author reply 583
DOI 10.1097/01.rli.0000137734.46713.1b, PubMed 15308941

Skotland T (2004)
Importance of using controls in in vivo experiments - Dr Skotland responds
Radiology, 233 (1), 298-299

Publications 2003

Kindberg GM, Tolleshaug H, Roos N, Skotland T (2003)
Hepatic clearance of Sonazoid perfluorobutane microbubbles by Kupffer cells does not reduce the ability of liver to phagocytose or degrade albumin microspheres
Cell Tissue Res, 312 (1), 49-54
DOI 10.1007/s00441-003-0698-0, PubMed 12712317

Publications 2002

Skotland T (2002)
Pitfalls when drawing conclusions from in vitro experiments with high concentrations of radiographic contrast agents
Radiology, 225 (3), 636-8
DOI 10.1148/radiol.2253020060, PubMed 12461241

Skotland T, Sontum PC, Oulie I (2002)
In vitro stability analyses as a model for metabolism of ferromagnetic particles (Clariscan), a contrast agent for magnetic resonance imaging
J Pharm Biomed Anal, 28 (2), 323-9
DOI 10.1016/s0731-7085(01)00592-1, PubMed 11929675

Publications 2001

Hvattum E, Normann PT, Oulie I, Uran S, Ringstad O, Skotland T (2001)
Determination of perfluorobutane in rat blood by automatic headspace capillary gas chromatography and selected ion monitoring mass spectrometry
J Pharm Biomed Anal, 24 (3), 487-94
DOI 10.1016/s0731-7085(00)00432-5, PubMed 11199228

Jacobsen PB, Oulie I, Christiansen C, Skotland T (2001)
Investigation of binding of 125I-iodixanol to high molecular weight substances after incubation with rat liver homogenates
Acta Radiol, 42 (1), 117-20
DOI 10.1080/028418501127346369, PubMed 11167344

Larsen A, Uran S, Jacobsen PB, Skotland T (2001)
Collision-induced dissociation of glycero phospholipids using electrospray ion-trap mass spectrometry
Rapid Commun Mass Spectrom, 15 (24), 2393-8
DOI 10.1002/rcm.520, PubMed 11746908

Schmidt PP, Toft KG, Skotland T, Andersson K (2001)
Stability and transmetallation of the magnetic resonance contrast agent MnDPDP measured by EPR
J Biol Inorg Chem, 7 (3), 241-8
DOI 10.1007/s007750100290, PubMed 11935348

Toft KG, Myrset AH, Skotland T (2001)
Dephosphorylation of MnDPDP and related compounds by acid and alkaline phosphatase
J Pharm Biomed Anal, 25 (3-4), 613-8
DOI 10.1016/s0731-7085(00)00587-2, PubMed 11377042

Uran S, Larsen A, Jacobsen PB, Skotland T (2001)
Analysis of phospholipid species in human blood using normal-phase liquid chromatography coupled with electrospray ionization ion-trap tandem mass spectrometry
J Chromatogr B Biomed Sci Appl, 758 (2), 265-75
DOI 10.1016/s0378-4347(01)00188-8, PubMed 11486836

Publications 2000

Christiansen C, Pichler WJ, Skotland T (2000)
Delayed allergy-like reactions to X-ray contrast media: mechanistic considerations
Eur Radiol, 10 (12), 1965-75
DOI 10.1007/s003300000543, PubMed 11305580

Kindberg GM, Tolleshaug H, Skotland T (2000)
Uptake and degradation of radioactively labelled albumin microspheres as markers for Kupffer cell phagocytosis
Cell Tissue Res, 300 (3), 397-400
DOI 10.1007/s004410000229, PubMed 10928270

Publications 1999

Jacobsen PB, Larsen A, Konarboland R, Skotland T (1999)
Biotransformation of nonionic X-Ray contrast agents In vivo and In vitro
Drug Metab Dispos, 27 (10), 1205-13
PubMed 10497149

Publications 1998

Hvattum E, Larsen A, Uran S, Michelsen PM, Skotland T (1998)
Specific detection and quantification of palmitoyl-stearoyl-phosphatidylserine in human blood using normal-phase liquid chromatography coupled with electrospray mass spectrometry
J Chromatogr B Biomed Sci Appl, 716 (1-2), 47-56
DOI 10.1016/s0378-4347(98)00303-x, PubMed 9824217

Sontum PC, Christiansen C, Kasparkova V, Skotland T (1998)
Evidence against molecular aggregates in concentrated solutions of X-ray contrast media
Int. J. Pharm., 169 (2), 203-212
DOI 10.1016/S0378-5173(98)00128-8

Publications 1997

Toft KG, Friisk GA, Skotland T (1997)
Mangafodipir trisodium injection, a new contrast medium for magnetic resonance imaging: detection and quantitation of the parent compound MnDPDP and metabolites in human plasma by high performance liquid chromatography
J Pharm Biomed Anal, 15 (7), 973-81
DOI 10.1016/s0731-7085(96)01945-0, PubMed 9160264

Toft KG, Hustvedt SO, Grant D, Friisk GA, Skotland T (1997)
Metabolism of mangafodipir trisodium (MnDPDP), a new contrast medium for magnetic resonance imaging, in beagle dogs
Eur J Drug Metab Pharmacokinet, 22 (1), 65-72
DOI 10.1007/BF03189786, PubMed 9179562

Toft KG, Hustvedt SO, Grant D, Martinsen I, Gordon PB, Friisk GA, Korsmo AJ, Skotland T (1997)
Metabolism and pharmacokinetics of MnDPDP in man
Acta Radiol, 38 (4 Pt 2), 677-89
DOI 10.1080/02841859709172400, PubMed 9245963

Toft KG, Kindberg GM, Skotland T (1997)
Mangafodipir trisodium injection, a new contrast medium for magnetic resonance imaging: in vitro metabolism and protein binding studies of the active component MnDPDP in human blood
J Pharm Biomed Anal, 15 (7), 983-8
DOI 10.1016/s0731-7085(96)01944-9, PubMed 9160265

Publications 1996

Myrset AH, Nicolaysen H, Toft K, Christiansen C, Skotland T (1996)
Structure and organization of albumin molecules forming the shell of air-filled microspheres: evidence for a monolayer of albumin molecules of multiple orientations stabilizing the enclosed air
Biotechnol Appl Biochem, 24 (2), 145-53
PubMed 8865606

Publications 1995

Hvattum E, Normann PT, Jamieson GC, Lai JJ, Skotland T (1995)
Detection and quantitation of gadolinium chelates in human serum and urine by high-performance liquid chromatography and post-column derivatization of gadolinium with Arsenazo III
J Pharm Biomed Anal, 13 (7), 927-32
DOI 10.1016/0731-7085(95)01311-8, PubMed 8562618

Jacobsen PB, Blindheim L, Skotland T (1995)
Bioanalytical methods for iodixanol and their application to studies on metabolism and protein binding
Acta Radiol Suppl, 399, 61-6
DOI 10.1177/0284185195036s39908, PubMed 8610531

Publications 1994

Christiansen C, Kryvi H, Sontum PC, Skotland T (1994)
Physical and biochemical characterization of Albunex, a new ultrasound contrast agent consisting of air-filled albumin microspheres suspended in a solution of human albumin
Biotechnol Appl Biochem, 19 (3), 307-20
PubMed 8031506

Christiansen C, Vebner AJ, Muan B, Vik H, Haider T, Nicolaysen H, Skotland T (1994)
Lack of an immune response to Albunex, a new ultrasound contrast agent based on air-filled albumin microspheres
Int Arch Allergy Immunol, 104 (4), 372-8
DOI 10.1159/000236694, PubMed 8038616

Hoff L, Christiansen C, Skotland T (1994)
Consideration about the contribution to acoustic backscatter from Albunex microspheres with different sizes
J Ultrasound Med, 13 (3), 181-2
DOI 10.7863/jum.1994.13.3.181, PubMed 7932974

Walday P, Tolleshaug H, Gjøen T, Kindberg GM, Berg T, Skotland T, Holtz E (1994)
Biodistributions of air-filled albumin microspheres in rats and pigs
Biochem J, 299 ( Pt 2) (Pt 2), 437-43
DOI 10.1042/bj2990437, PubMed 8172604

Publications 1993

Hellebust H, Christiansen C, Skotland T (1993)
Biochemical characterization of air-filled albumin microspheres
Biotechnol Appl Biochem, 18 (3), 227-37
PubMed 8297503

IEE CONF PUBL (369), 103-108

Publications 1992

de Jong N, Hoff L, Skotland T, Bom N (1992)
Absorption and scatter of encapsulated gas filled microspheres: theoretical considerations and some measurements
Ultrasonics, 30 (2), 95-103
DOI 10.1016/0041-624x(92)90041-j, PubMed 1557838

Publications 1984

Skotland T, Flatmark T (1984)
The copper-enzyme dopamine beta-monooxygenase: studies on the ability of several metals to inhibit the enzyme activity and to replace the copper
J Inorg Biochem, 20 (1), 61-8
DOI 10.1016/0162-0134(84)80006-9, PubMed 6693870

Publications 1983

Skotland T, Flatmark T (1983)
Dopamine beta-monooxygenase. Binding to apoenzyme and rapid exchange in holoenzyme of 64Cu studied with high-performance size-exclusion gel chromatography
Eur J Biochem, 132 (1), 171-5
DOI 10.1111/j.1432-1033.1983.tb07343.x, PubMed 6840081

Skotland T, Ljones T (1983)
Enzyme-bound copper of dopamine beta-monooxygenase. Activation of the holoenzyme by added copper and uncoupling of electron transfer from hydroxylation by copper salicylate
J Inorg Biochem, 18 (1), 11-8
DOI 10.1016/0162-0134(83)85035-1, PubMed 6834029

Publications 1982

Døskeland A, Ljones T, Skotland T, Flatmark T (1982)
Phenylalanine 4-monooxygenase from bovine and rat liver: some physical and chemical properties
Neurochem Res, 7 (4), 407-21
DOI 10.1007/BF00965494, PubMed 7110509

Publications 1981

Skotland T (1981)
Studies on the interaction of Cibacron Blue and Procion Red with dopamine beta-monooxygenase
Biochim Biophys Acta, 659 (2), 312-25
DOI 10.1016/0005-2744(81)90057-7, PubMed 7260097

Publications 1980

Skotland T, Ljones T (1980)
Direct spectrophotometric detection of ascorbate free radical formed by dopamine beta-monooxygenase and by ascorbate oxidase
Biochim Biophys Acta, 630 (1), 30-5
DOI 10.1016/0304-4165(80)90134-8, PubMed 7388045

Skotland T, Ljones T (1980)
Inactivation of dopamine beta-monooxygenase by hydrogen peroxide and by ascorbate
Arch Biochem Biophys, 201 (1), 81-7
DOI 10.1016/0003-9861(80)90489-0, PubMed 7396512

Skotland T, Petersson L, Bäckström D, Ljones T, Flatmark T, Ehrenberg A (1980)
Electron paramagnetic resonance of the copper in dopamine beta-monooxygenase. Rapid reduction by ascorbate, the steady-state redox level, chelation with EDTA, and reactivation of the apoenzyme by added copper
Eur J Biochem, 103 (1), 5-11
DOI 10.1111/j.1432-1033.1980.tb04282.x, PubMed 6244155

Publications 1979

Aksnes A, Skotland T, Flatmark T, Ljones T (1979)
Bovine dihydropteridine reductase: purification by affinity chromatography and comparison of enzymes from liver and adrenal medulla
Neurochem Res, 4 (3), 385-98
DOI 10.1007/BF00963808, PubMed 223079

Ljones T, Skotland T (1979)
Evidence from the acceleration of cytochrome c reduction for the formation of ascorbate free radical by dopamine beta-monooxygenase
FEBS Lett, 108 (1), 25-7
DOI 10.1016/0014-5793(79)81170-9, PubMed 230081

Skotland T (1979)
Studies on dopamine β-monooxygenase (dopamine β-hydroxylase) from bovine adrenal medulla
[Forfatteren], [Bergen], 1 b.(fl. pag.)
BIBSYS 822186756

Skotland T, Flatmark T (1979)
On the amphiphilic and hydrophilic forms of dopamine beta-mono-oxygenase in bovine adrenal medulla
J Neurochem, 32 (6), 1861-3
DOI 10.1111/j.1471-4159.1979.tb02302.x, PubMed 448373

Skotland T, Ljones T (1979)
The enzyme-bound copper of dopamine beta-monooxygenase. Reaction with copper chelators, preparation of the apoprotein, and kinetics of the reconstitution by added copper
Eur J Biochem, 94 (1), 145-51
DOI 10.1111/j.1432-1033.1979.tb12881.x, PubMed 108101

INORG PERSPECT BIOL, 2 (2), 151-180

Publications 1978

Flatmark T, Skotland T, Ljones T, Ingebretsen OC (1978)
Fluorimetric detection of octopamine in high-performance liquid chromatography and its application to the assay of dopamine beta-monooxygenase in human serum
J Chromatogr, 146 (3), 433-8
DOI 10.1016/s0378-4347(00)81201-3, PubMed 363735

Ljones T, Flatmark T, Skotland T, Petersson L, Bäckström D, Ehrenberg A (1978)
Dopamine beta-monooxygenase: electron paramagnetic resonance and oxidation--reduction properties of the enzyme-bound copper
FEBS Lett, 92 (1), 81-4
DOI 10.1016/0014-5793(78)80726-1, PubMed 208872

Skotland T, Ljones T, Flatmark T (1978)
Dopamine beta-monooxygenase: reduced enzyme needs additional reductant for completion of the catalytic cycle
Biochem Biophys Res Commun, 84 (1), 83-8
DOI 10.1016/0006-291x(78)90266-8, PubMed 728139

Ueland PM, Skotland T, Døskeland SO, Flatmark T (1978)
An adenosine 3':5'-monophosphate-adenosine binding protein from mouse liver: some physicochemical properties
Biochim Biophys Acta, 533 (1), 57-65
DOI 10.1016/0005-2795(78)90547-0, PubMed 205267

Publications 1977

Int. J. Pept. Protein Res., 10 (4), 311-314

Skotland T, Ljones T, Flatmark T, Sletten K (1977)
NH2-terminal sequence of dopamine beta-hydroxylase from bovine adrenal medulla
Biochem Biophys Res Commun, 74 (4), 1483-9
DOI 10.1016/0006-291x(77)90609-x, PubMed 843373

Terland O, Slinde E, Skotland T, Flatmark T (1977)
Inhibition of dopamine beta-mono-oxygenase by non-ionic detergents of the triton X-series
FEBS Lett, 76 (1), 86-90
DOI 10.1016/0014-5793(77)80126-9, PubMed 852607

Publications 1976

Ljones T, Skotland T, Flatmark T (1976)
Purification and characterization of dopamine beta-hydroxylase from bovine adrenal medulla
Eur J Biochem, 61 (2), 525-33
DOI 10.1111/j.1432-1033.1976.tb10047.x, PubMed 1248471

Publications 1974

Skotland T (1974)
Rensing og karakterisering av et fragment av humant protrombin: en proteinkjemisk studie, særlig med henblikk på dansyleringsmetodikken
[T. Skotland], Tromsø, 117 bl.
BIBSYS 910187290

Skotland T, Holm T, Osterud B, Flengsrud R, Prydz H (1974)
The localization of a vitamin K-induced modification in an N-terminal fragment of human prothrombin
Biochem J, 143 (1), 29-37
DOI 10.1042/bj1430029, PubMed 4219283

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