Camilla Raiborg
- Assistant Group Leader, Senior Scientist (Institute for Cancer Research)
- +47 22 78 18 20
Camilla is in charge of the project Protein dynamics in tumor suppressor pathways
Camilla defended her PhD thesis in 2005 and continues as a postdoc in the Stenmark lab.
From the news:
Nature Communications paper from Wenzel and Raiborg: Timing of growth factor receptor downregulation
Camilla Raiborg's work presented in popularised form on forskning.no:Filming live cancer cells
Nature article from Camilla Raiborg: Formation of cellular protrusions
Review in Nature about ESCRT proteins
Camilla's picture on the cover of the 2009 edition of Experimental Cell Research
Publications 2021
The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes
Nat. Commun., 12 (1), 6577
DOI 10.1038/s41467-021-26775-x
Publications 2020
Protein crowding mediates membrane remodeling in upstream ESCRT-induced formation of intraluminal vesicles
Proc. Natl. Acad. Sci. U. S. A., 117 (46), 28614-28624
DOI 10.1073/pnas.2014228117
Clathrin regulates Wnt/beta-catenin signaling by affecting Golgi to plasma membrane transport of transmembrane proteins
J. Cell Sci., 133 (13), jcs244467
DOI 10.1242/jcs.244467
Protrudin-mediated ER-endosome contact sites promote MT1-MMP exocytosis and cell invasion
J. Cell Biol., 219 (8), e202003063
DOI 10.1083/jcb.202003063
Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation
Nat. Cell Biol., 22 (7), 856-+
DOI 10.1038/s41556-020-0537-5
ESCRT-mediated phagophore sealing during mitophagy
Autophagy, 16 (5), 826-841
DOI 10.1080/15548627.2019.1639301
Publications 2019
Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth
eLife, 8, e51063
DOI 10.7554/eLife.51063
Publications 2018
Concerted ESCRT and clathrin recruitment waves define the timing and morphology of intraluminal vesicle formation
Nat. Commun., 9, 2932
DOI 10.1038/s41467-018-05345-8
Publications 2017
Cellular Functions and Molecular Mechanisms of the ESCRT Membrane-Scission Machinery
Trends Biochem.Sci., 42 (1), 42-56
DOI 10.1016/j.tibs.2016.08.016
PtdIns3P controls mTORC1 signaling through lysosomal positioning
J. Cell Biol., 216 (12), 4217-4233
DOI 10.1083/jcb.201611073
Suppressing mTORC1 on the lysosome
Embo J., 36 (13), 1809-1810
DOI 10.15252/embj.201797469
Publications 2016
ALIX and ESCRT-I/II function as parallel ESCRT-III recruiters in cytokinetic abscission
J. Cell Biol., 212 (5), 499-513
DOI 10.1083/jcb.201507009
Plasma membrane repairs by small GTPase Rab3a
J. Cell Biol., 213 (6), 613-615
DOI 10.1083/jcb.201606006
Phosphoinositides in membrane contact sites
Biochem. Soc. Trans., 44, 425-430
DOI 10.1042/BST20150190
ER-endosome contact sites in endosome positioning and protrusion outgrowth
Biochem. Soc. Trans., 44, 441-446
DOI 10.1042/BST20150246
Interaction with epsin 1 regulates the constitutive clathrin-dependent internalization of ErbB3
Biochim. Biophys. Acta-Mol. Cell Res., 1863 (6), 1179-1188
DOI 10.1016/j.bbamcr.2016.03.011
Publications 2015
An ER clamp for endosome fission
Embo J., 34 (2), 136-137
DOI 10.15252/embj.201490707
Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth
Nature, 520 (7546), 234-+
DOI 10.1038/nature14359
ER-endosome contact sites: molecular compositions and functions
Embo J., 34 (14), 1848-1858
DOI 10.15252/embj.201591481
Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing
Nature, 522 (7555), 231-+
DOI 10.1038/nature14408
Publications 2014
CK2 involvement in ESCRT-III complex phosphorylation
Arch. Biochem. Biophys., 545, 83-91
DOI 10.1016/j.abb.2014.01.006
ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4
Nat. Cell Biol., 16 (6), 547-+
DOI 10.1038/ncb2959
Publications 2013
Membrane remodeling by the PX-BAR protein SNX18 promotes autophagosome formation
J. Cell Biol., 202 (2), 331-349
DOI 10.1083/jcb.201205129
ClassIII phosphatidylinositol 3-kinase and its catalytic product PtdIns3P in regulation of endocytic membrane traffic
FEBS J., 280 (12), 2730-2742
DOI 10.1111/febs.12116
Phosphatidylinositol 3-phosphate, a lipid that regulates membrane dynamics, protein sorting and cell signalling
Bioessays, 35 (10), 900-912
DOI 10.1002/bies.201300064
Publications 2012
The PtdIns3P-Binding Protein Phafin 2 Mediates Epidermal Growth Factor Receptor Degradation by Promoting Endosome Fusion
Traffic, 13 (11), 1547-1563
DOI 10.1111/j.1600-0854.2012.01400.x
Publications 2011
SPG20, a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesis
Oncogene, 30 (37), 3967-3978
DOI 10.1038/onc.2011.109
A Helix for the Final Cut
Science, 331 (6024), 1533-1534
DOI 10.1126/science.1204208
Publications 2010
PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody
Nat. Cell Biol., 12 (4), 362-U140
DOI 10.1038/ncb2036
Publications 2009
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins
Nature, 458 (7237), 445-452
DOI 10.1038/nature07961
Dual degradation mechanisms ensure disposal of NHE6 mutant protein associated with neurological disease
Exp. Cell Res., 315 (17), 3014-3027
DOI 10.1016/j.yexcr.2009.07.012
Publications 2008
Differential functions of Hrs and ESCRT proteins in endocytic membrane trafficking
Exp. Cell Res., 314 (4), 801-813
DOI 10.1016/j.yexcr.2007.10.014
An endosomally localized isoform of Eps15 interacts with Hrs to mediate degradation of epidermal growth factor receptor
J. Cell Biol., 180 (6), 1205-1218
DOI 10.1083/jcb.200708115
Publications 2007
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease
J. Cell Biol., 179 (3), 485-500
DOI 10.1083/jcb.200702115
Publications 2006
The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor
Mol. Biol. Cell, 17 (6), 2513-2523
DOI 10.1091/mbc.E05-10-0915
Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting
Nat. Struct. Mol. Biol., 13 (3), 272-277
DOI 10.1038/nsmb1051
Regulation of ubiquitin-binding proteins by monoubiquitination
Nat. Cell Biol., 8 (2), 163-U45
DOI 10.1038/ncb1354
Both clathrin-positive and -negative coats are involved in endosomal sorting of the EGF receptor
Exp. Cell Res., 312 (16), 3036-3048
DOI 10.1016/j.yexcr.2006.06.004
A new side to ubiquitin
Trends Biochem.Sci., 31 (10), 541-544
DOI 10.1016/j.tibs.2006.07.009
Flat clathrin coats on endosomes mediate degradative protein sorting by scaffolding Hrs in dynamic microdomains
J. Cell Sci., 119 (12), 2414-2424
DOI 10.1242/jcs.02978
Publications 2005
Hrs makes receptors silent: a key to endosomal protein sorting
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 255, 1 b. (flere pag.)
BIBSYS 050440411, ISBN 82-8072-628-4
Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain
J. Biol. Chem., 280 (20), 19600-19606
DOI 10.1074/jbc.M501510200
Publications 2004
The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation
Mol. Biol. Cell, 15 (9), 4337-4346
DOI 10.1091/mbc.E04-03-0250
Cb1-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits
Mol. Biol. Cell, 15 (8), 3591-3604
DOI 10.1091/mbc.E04-01-0041
Publications 2003
STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes
J. Biol. Chem., 278 (14), 12513-12521
DOI 10.1074/jbc.M210843200
Phosphatidylinositol 3-phosphate is found in microdomains of early endosomes
Histochem. Cell Biol., 120 (6), 445-453
DOI 10.1007/s00418-003-0591-7
The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4
Dev. Cell, 5 (5), 709-722
DOI 10.1016/S1534-5807(03)00321-6
Protein sorting into multivesicular endosomes
Curr. Opin. Cell Biol., 15 (4), 446-455
DOI 10.1016/S0955-0674(03)00080-2
Publications 2002
Phosphorylation of Hrs downstream of the epidermal growth factor receptor
Eur. J. Biochem., 269 (16), 3881-3887
DOI 10.1046/j.1432-1033.2002.03046.x
Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes
Nat. Cell Biol., 4 (5), 394-398
DOI 10.1038/ncb791
Hrs and endocytic sorting of ubiquitinated membrane proteins
Cell Struct. Funct., 27 (6), 403-408
DOI 10.1247/csf.27.403
Publications 2001
Hrs recruits clathrin to early endosomes
Embo J., 20 (17), 5008-5021
DOI 10.1093/emboj/20.17.5008
Function of Hrs in endocytic trafficking and signalling
Biochem. Soc. Trans., 29, 472-475
DOI 10.1042/BST0290472
FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes
J. Cell Sci., 114 (12), 2255-2263
Publications 2000
Ultrastructural characterization of the delimiting membranes of isolated autophagosomes and amphisomes by freeze-fracture electron microscopy
Eur. J. Cell Biol., 79 (12), 871-882
DOI 10.1078/0171-9335-00125
Autophagosome-associated variant isoforms of cytosolic enzymes
Biochem. J., 352, 773-781
DOI 10.1042/0264-6021:3520773
Publications 1999
Identifisering av autofagosom- assosierte proteiner
C. Raiborg, Oslo, 1 b. (flere pag.)
BIBSYS 991523342