Eva M. Wenzel

  • Scientist (InvaCell)
  • +47 22 78 18 19

From the news:

Nature Communications article from Raiborg project group: Cancer cells transfer their invasive properties to non-invasive cells

Nature Communications paper from Wenzel and Raiborg: Timing of growth factor receptor downregulation

Publication as Eva M. Kohler (2008-2010)

Kohler EM, Derungs A, Daum G, Behrens J, Schneikert J (2008). Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours. Hum Mol Genet, 17(13): 1978-1987

Kohler EM, Brauburger K, Behrens J, Schneikert J (2009). Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients. Oncogene, 29(11): 1663-1671

Kohler EM, Chandra SH, Behrens J, Schneikert J (2010). Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours. Hum Mol Genet, 18(2): 213-226

Welzel O, Tischbirek CH, Jung J, Kohler EM, Svetlitchny A, Henkel AW, Kornhuber J, Groemer TW (2010). Synapse clusters are preferentially formed by synapses with large recycling pool sizes. PLoS One, 5(10): e13514

 

Publications 2024

Wenzel EM, Pedersen NM, Elfmark LA, Wang L, Kjos I, Stang E, Malerød L, Brech A, Stenmark H, Raiborg C (2024)
Intercellular transfer of cancer cell invasiveness via endosome-mediated protease shedding
Nat Commun, 15 (1), 1277
DOI 10.1038/s41467-024-45558-8, PubMed 38341434

Publications 2023

Elfmark LA, Wenzel EM, Wang L, Pedersen NM, Stenmark H, Raiborg C (2023)
Protrudin-mediated ER-endosome contact sites promote phagocytosis
Cell Mol Life Sci, 80 (8), 216
DOI 10.1007/s00018-023-04862-0, PubMed 37468729

Migliano SM, Schultz SW, Wenzel EM, Takáts S, Liu D, Mørk S, Tan KW, Rusten TE, Raiborg C, Stenmark H (2023)
Removal of hypersignaling endosomes by simaphagy
Autophagy, 20 (4), 769-791
DOI 10.1080/15548627.2023.2267958, PubMed 37840274

Nähse V, Raiborg C, Tan KW, Mørk S, Torgersen ML, Wenzel EM, Nager M, Salo VT, Johansen T, Ikonen E, Schink KO, Stenmark H (2023)
ATPase activity of DFCP1 controls selective autophagy
Nat Commun, 14 (1), 4051
DOI 10.1038/s41467-023-39641-9, PubMed 37422481

Publications 2022

Migliano SM, Wenzel EM, Stenmark H (2022)
Biophysical and molecular mechanisms of ESCRT functions, and their implications for disease
Curr Opin Cell Biol, 75, 102062
DOI 10.1016/j.ceb.2022.01.007, PubMed 35248976

Radulovic M, Wenzel EM, Gilani S, Holland LK, Lystad AH, Phuyal S, Olkkonen VM, Brech A, Jäättelä M, Maeda K, Raiborg C, Stenmark H (2022)
Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair
EMBO J, 41 (24), e112677
DOI 10.15252/embj.2022112677, PubMed 36408828

Wenzel EM, Elfmark LA, Stenmark H, Raiborg C (2022)
ER as master regulator of membrane trafficking and organelle function
J Cell Biol, 221 (10)
DOI 10.1083/jcb.202205135, PubMed 36108241

Wenzel EM, Raiborg C (2022)
ER-endosome contacts master the ins and outs of secretory endosomes
J Cell Biol, 221 (12)
DOI 10.1083/jcb.202210033, PubMed 36355088

Publications 2021

Vogl T, Kickenweiz T, Pitzer J, Sturmberger L, Weninger A, Biggs BW, Köhler EM, Baumschlager A, Fischer JE, Hyden P, Wagner M, Baumann M, Borth N, Geier M, Ajikumar PK, Glieder A (2021)
Publisher Correction: Engineered bidirectional promoters enable rapid multi-gene co-expression optimization
Nat Commun, 12 (1), 1287
DOI 10.1038/s41467-021-21369-z, PubMed 33602905

Publications 2020

Liese S, Wenzel EM, Kjos I, Rojas Molina R, Schultz SW, Brech A, Stenmark H, Raiborg C, Carlson A (2020)
Protein crowding mediates membrane remodeling in upstream ESCRT-induced formation of intraluminal vesicles
Proc Natl Acad Sci U S A, 117 (46), 28614-28624
DOI 10.1073/pnas.2014228117, PubMed 33139578

Munthe E, Raiborg C, Stenmark H, Wenzel EM (2020)
Clathrin regulates Wnt/β-catenin signaling by affecting Golgi to plasma membrane transport of transmembrane proteins
J Cell Sci, 133 (13)
DOI 10.1242/jcs.244467, PubMed 32546530

Pedersen NM, Wenzel EM, Wang L, Antoine S, Chavrier P, Stenmark H, Raiborg C (2020)
Protrudin-mediated ER-endosome contact sites promote MT1-MMP exocytosis and cell invasion
J Cell Biol, 219 (8)
DOI 10.1083/jcb.202003063, PubMed 32479595

Publications 2019

Zhen Y, Spangenberg H, Munson MJ, Brech A, Schink KO, Tan KW, Sørensen V, Wenzel EM, Radulovic M, Engedal N, Simonsen A, Raiborg C, Stenmark H (2019)
ESCRT-mediated phagophore sealing during mitophagy
Autophagy, 16 (5), 826-841
DOI 10.1080/15548627.2019.1639301, PubMed 31366282

Publications 2018

Radulovic M, Schink KO, Wenzel EM, Nähse V, Bongiovanni A, Lafont F, Stenmark H (2018)
ESCRT-mediated lysosome repair precedes lysophagy and promotes cell survival
EMBO J, 37 (21)
DOI 10.15252/embj.201899753, PubMed 30314966

Wenzel EM, Schultz SW, Schink KO, Pedersen NM, Nähse V, Carlson A, Brech A, Stenmark H, Raiborg C (2018)
Concerted ESCRT and clathrin recruitment waves define the timing and morphology of intraluminal vesicle formation
Nat Commun, 9 (1), 2932
DOI 10.1038/s41467-018-05345-8, PubMed 30050131

Publications 2017

O'Farrell F, Lobert VH, Sneeggen M, Jain A, Katheder NS, Wenzel EM, Schultz SW, Tan KW, Brech A, Stenmark H, Rusten TE (2017)
Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation
Nat Cell Biol, 19 (12), 1412-1423
DOI 10.1038/ncb3631, PubMed 29084199

Thorvaldsen TE, Pedersen NM, Wenzel EM, Stenmark H (2017)
Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and β-Catenin Degradation
PLoS One, 12 (1), e0170508
DOI 10.1371/journal.pone.0170508, PubMed 28107521

Publications 2016

Christ L, Raiborg C, Wenzel EM, Campsteijn C, Stenmark H (2016)
Cellular Functions and Molecular Mechanisms of the ESCRT Membrane-Scission Machinery
Trends Biochem Sci, 42 (1), 42-56
DOI 10.1016/j.tibs.2016.08.016, PubMed 27669649

Christ L, Wenzel EM, Liestøl K, Raiborg C, Campsteijn C, Stenmark H (2016)
ALIX and ESCRT-I/II function as parallel ESCRT-III recruiters in cytokinetic abscission
J Cell Biol, 212 (5), 499-513
DOI 10.1083/jcb.201507009, PubMed 26929449

Pedersen NM, Thorvaldsen TE, Schultz SW, Wenzel EM, Stenmark H (2016)
Formation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity
PLoS One, 11 (8), e0160507
DOI 10.1371/journal.pone.0160507, PubMed 27482906

Raiborg C, Wenzel EM, Pedersen NM, Stenmark H (2016)
Phosphoinositides in membrane contact sites
Biochem Soc Trans, 44 (2), 425-30
DOI 10.1042/BST20150190, PubMed 27068950

Raiborg C, Wenzel EM, Pedersen NM, Stenmark H (2016)
ER-endosome contact sites in endosome positioning and protrusion outgrowth
Biochem Soc Trans, 44 (2), 441-6
DOI 10.1042/BST20150246, PubMed 27068952

Publications 2015

Bauereiss A, Welzel O, Jung J, Grosse-Holz S, Lelental N, Lewczuk P, Wenzel EM, Kornhuber J, Groemer TW (2015)
Surface Trafficking of APP and BACE in Live Cells
Traffic, 16 (6), 655-75
DOI 10.1111/tra.12270, PubMed 25712587

Raiborg C, Wenzel EM, Pedersen NM, Olsvik H, Schink KO, Schultz SW, Vietri M, Nisi V, Bucci C, Brech A, Johansen T, Stenmark H (2015)
Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth
Nature, 520 (7546), 234-8
DOI 10.1038/nature14359, PubMed 25855459

Raiborg C, Wenzel EM, Stenmark H (2015)
ER-endosome contact sites: molecular compositions and functions
EMBO J, 34 (14), 1848-58
DOI 10.15252/embj.201591481, PubMed 26041457

Thorvaldsen TE, Pedersen NM, Wenzel EM, Schultz SW, Brech A, Liestøl K, Waaler J, Krauss S, Stenmark H (2015)
Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes
Mol Cancer Res, 13 (11), 1487-501
DOI 10.1158/1541-7786.MCR-15-0125, PubMed 26124443

Publications 2014

Purohit P, Perez-Branguli F, Prots I, Borger E, Gunn-Moore F, Welzel O, Loy K, Wenzel EM, Grömer TW, Brachs S, Holzer M, Buslei R, Fritsch K, Regensburger M, Böhm KJ, Winner B, Mielenz D (2014)
The Ca2+ sensor protein swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons
PLoS One, 9 (8), e103976
DOI 10.1371/journal.pone.0103976, PubMed 25133820

Schneikert J, Ruppert JG, Behrens J, Wenzel EM (2014)
different Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coli
PLoS One, 9 (4), e94413
DOI 10.1371/journal.pone.0094413, PubMed 24722208

Publications 2013

Lueke K, Kaiser T, Svetlitchny A, Welzel O, Wenzel EM, Tyagarajan S, Kornhuber J, Groemer TW (2013)
Basic presynaptic functions in hippocampal neurons are not affected by acute or chronic lithium treatment
J Neural Transm (Vienna), 121 (2), 211-9
DOI 10.1007/s00702-013-1087-9, PubMed 24036894

Schneikert J, Vijaya Chandra SH, Ruppert JG, Ray S, Wenzel EM, Behrens J (2013)
Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation
PLoS One, 8 (7), e68072
DOI 10.1371/journal.pone.0068072, PubMed 23840886

Publications 2012

Oppelt A, Lobert VH, Haglund K, Mackey AM, Rameh LE, Liestøl K, Schink KO, Pedersen NM, Wenzel EM, Haugsten EM, Brech A, Rusten TE, Stenmark H, Wesche J (2012)
Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration
EMBO Rep, 14 (1), 57-64
DOI 10.1038/embor.2012.183, PubMed 23154468

Tischbirek CH, Wenzel EM, Zheng F, Huth T, Amato D, Trapp S, Denker A, Welzel O, Lueke K, Svetlitchny A, Rauh M, Deusser J, Schwab A, Rizzoli SO, Henkel AW, Müller CP, Alzheimer C, Kornhuber J, Groemer TW (2012)
Use-dependent inhibition of synaptic transmission by the secretion of intravesicularly accumulated antipsychotic drugs
Neuron, 74 (5), 830-44
DOI 10.1016/j.neuron.2012.04.019, PubMed 22681688

Wenzel EM, Morton A, Ebert K, Welzel O, Kornhuber J, Cousin MA, Groemer TW (2012)
Key physiological parameters dictate triggering of activity-dependent bulk endocytosis in hippocampal synapses
PLoS One, 7 (6), e38188
DOI 10.1371/journal.pone.0038188, PubMed 22675521

Publications 2010

Welzel O, Tischbirek CH, Jung J, Kohler EM, Svetlitchny A, Henkel AW, Kornhuber J, Groemer TW (2010)
Synapse clusters are preferentially formed by synapses with large recycling pool sizes
PLoS One, 5 (10), e13514
DOI 10.1371/journal.pone.0013514, PubMed 20976002

Publications 2009

Kohler EM, Brauburger K, Behrens J, Schneikert J (2009)
Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients
Oncogene, 29 (11), 1663-71
DOI 10.1038/onc.2009.447, PubMed 19966865

Publications 2008

Kohler EM, Chandra SH, Behrens J, Schneikert J (2008)
Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours
Hum Mol Genet, 18 (2), 213-26
DOI 10.1093/hmg/ddn338, PubMed 18854359

Kohler EM, Derungs A, Daum G, Behrens J, Schneikert J (2008)
Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours
Hum Mol Genet, 17 (13), 1978-87
DOI 10.1093/hmg/ddn095, PubMed 18387968

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