Our paper on the progression of HER2+ DCIS is out. Using spatial transcriptomics and single cell proteomics technology we found an intriguing association between metabolic processes in the intraductal cancer cells and extraductal B cell abundance in DCIS. https://doi.org/10.1186/s13058-025-01990-2
Finally, our multicentre study on ctDNA in Endometrial Cancer is published. Great collaboration across three centres and the beginning of many more collaborative studies to come! https://doi.org/10.1016/j.ygyno.2025.03.002
Congratulations to Kristina Lindemann for receiving funding from the Norwegian Cancer Society. We are looking forward to exciting collaboration ahead. Camilla Krakstad, UiB, Kristina Lindemann, OUS and Carlos Casas Arozamena, ICR.
Therese Sørlie and Rob Clarke are the editors of this newly published book, A Guide to Breast Cancer Research. It provides an overview of the most important areas in contemporary breast cancer research covering topics such as cellular heterogeneity, molecular mechanisms, targeted therapy and resistance. It is written as a guide for young investigators with contributions from leading scientists in the field including Walid Khaled, Fariba Behbod, Richard Iggo and Mohamed Bentires-Alj. A must-have for all young and old researchers and others with interest in breast cancer research!
We are thrilled that our project addressing the role of B-cells in breast tumor invasion has been funded by the South-Eastern Norway Regional Health Authority. Looking forward to working three more years with DCIS and breast tumor invasion, this time with even more focus on the immune mechanisms of invasion.
This week, Jens Henrik Norum and Helga Bergholtz are in San Diego to present their work on spatial transcriptomics of ductal carcinoma in situ on the AACR Advances in Breast Cancer Research conference. They will present their poster titled “Spatial transcriptomics of ductal carcinoma in situ reveal subtype specific differences in tumoral and stromal cell compartments” and have also been selected for holding a short talk.
Cand. med. Hedda von der Lippe Gythfeldt has succesfully defended her thesis: "Identifying molecular factors responsible for treatment response and resistance in a breast cancer study and a breast cancer model" for the degree of PhD at Institute for Clinical Medicine, University of Oslo. We are very proud and happy for her achievement!
Our group has received funding from the Norwegian Cancer Society for a new project on DCIS: "Spatial heterogeneity and breast cancer lineages in Ductal Carcinoma In Situ". Read more here (in Norwegian).
