Publications 2025

Lapão A, Johnson LS, Trachsel-Moncho L, Rodgers SJ, Singh S, Ng MYW, Nakken S, Eskelinen EL, Simonsen A (2025)
The RAB27A effector SYTL5 regulates mitophagy and mitochondrial metabolism
Elife, 14
DOI 10.7554/eLife.105541, PubMed 41294009

Ooms LM, Ferguson DT, Rodgers SJ, Sukhija KK, Jones EI, Csolle MP, Yip HYK, Daly RJ, Tiganis T, McLean CA, Papa A, Mitchell CA (2025)
Non-redundant roles of the phosphoinositide phosphatases PTEN and PIPP in PI3K/AKT signaling in breast cancer
Commun Biol, 9 (1), 96
DOI 10.1038/s42003-025-09364-2, PubMed 41408399

Publications 2023

Rodgers SJ, Mitchell CA, Ooms LM (2023)
The mechanisms of class 1A PI3K and Wnt/β-catenin coupled signaling in breast cancer
Biochem Soc Trans, 51 (4), 1459-1472
DOI 10.1042/BST20220866, PubMed 37471270

York HM, Joshi K, Wright CS, Kreplin LZ, Rodgers SJ, Moorthi UK, Gandhi H, Patil A, Mitchell CA, Iyer-Biswas S, Arumugam S (2023)
Deterministic early endosomal maturations emerge from a stochastic trigger-and-convert mechanism
Nat Commun, 14 (1), 4652
DOI 10.1038/s41467-023-40428-1, PubMed 37532690

Publications 2022

Nanayakkara R, Gurung R, Rodgers SJ, Eramo MJ, Ramm G, Mitchell CA, McGrath MJ (2022)
Autophagic lysosome reformation in health and disease
Autophagy, 19 (5), 1378-1395
DOI 10.1080/15548627.2022.2128019, PubMed 36409033

Rodgers SJ, Jones EI, Arumugam S, Hamila SA, Danne J, Gurung R, Eramo MJ, Nanayakkara R, Ramm G, McGrath MJ, Mitchell CA (2022)
Endosome maturation links PI3Kα signaling to lysosome repopulation during basal autophagy
EMBO J, 41 (19), e110398
DOI 10.15252/embj.2021110398, PubMed 35968799

Rodgers SJ, Jones EI, Mitchell CA, McGrath MJ (2022)
Sequential conversion of PtdIns3P to PtdIns(3,5)P₂ via endosome maturation couples nutrient signaling to lysosome reformation and basal autophagy
Autophagy, 19 (4), 1365-1367
DOI 10.1080/15548627.2022.2124499, PubMed 36103410

Rodgers SJ, Ooms LM, Mitchell CA (2022)
The FDA-Approved Drug Pyrvinium Selectively Targets ER⁺ Breast Cancer Cells with High INPP4B Expression
Cancers (Basel), 15 (1)
DOI 10.3390/cancers15010135, PubMed 36612130

Publications 2021

Hamila SA, Ooms LM, Rodgers SJ, Mitchell CA (2021)
The INPP4B paradox: Like PTEN, but different
Adv Biol Regul, 82, 100817
DOI 10.1016/j.jbior.2021.100817, PubMed 34216856

Rodgers SJ, Hamila SA, Mitchell CA, Ooms LM (2021)
A late endosome signaling hub that couples PI3Kα and WNT/β-catenin signaling in breast cancer
Mol Cell Oncol, 8 (4), 1954470
DOI 10.1080/23723556.2021.1954470, PubMed 34616876

Rodgers SJ, Ooms LM, Oorschot VMJ, Schittenhelm RB, Nguyen EV, Hamila SA, Rynkiewicz N, Gurung R, Eramo MJ, Sriratana A, Fedele CG, Caramia F, Loi S, Kerr G, Abud HE, Ramm G, Papa A, Ellisdon AM, Daly RJ, McLean CA, Mitchell CA (2021)
INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
Nat Commun, 12 (1), 3140
DOI 10.1038/s41467-021-23241-6, PubMed 34035258

Publications 2019

Ma X, Zhang L, Song J, Nguyen E, Lee RS, Rodgers SJ, Li F, Huang C, Schittenhelm RB, Chan H, Chheang C, Wu J, Brown KK, Mitchell CA, Simpson KJ, Daly RJ (2019)
Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation
Nat Commun, 10 (1), 296
DOI 10.1038/s41467-018-08154-1, PubMed 30655532

Publications 2017

Rodgers SJ, Ferguson DT, Mitchell CA, Ooms LM (2017)
Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases
Biosci Rep, 37 (1)
DOI 10.1042/BSR20160432, PubMed 28082369