Hanne Scholz
- Senior scientist, MSc, PhD
- +47 23073526, +47 97514215
Publications 2024
Pump-Less, Recirculating Organ-on-Chip (rOoC) Platform to Model the Metabolic Crosstalk between Islets and Liver
Adv Healthc Mater, 13 (13), e2303785
DOI 10.1002/adhm.202303785, PubMed 38221504
Expert Revision of Key Elements for Clinical-Grade Production and Qualification of Perinatal Derivatives
Stem Cells Transl Med, 13 (1), 14-29
DOI 10.1093/stcltm/szad068, PubMed 38071447
Preparative agarose gel electrophoresis for reducing matrix interferences of organoid cell medium prior to LC-MS analysis of insulin
J Chromatogr A, 1717, 464669
DOI 10.1016/j.chroma.2024.464669, PubMed 38278130
The age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loop
Mech Ageing Dev, 220, 111951
DOI 10.1016/j.mad.2024.111951, PubMed 38825059
Cautious Optimism Warranted for Stem Cell-Derived Islet Transplantation in Type 2 Diabetes
Transpl Int, 37, 13358
DOI 10.3389/ti.2024.13358, PubMed 39131791
Cell identity dynamics and insight into insulin secretagogues when employing stem cell-derived islets for disease modeling
Front Bioeng Biotechnol, 12, 1392575
DOI 10.3389/fbioe.2024.1392575, PubMed 38933536
Glucose Concentration in Regulating Induced Pluripotent Stem Cells Differentiation Toward Insulin-Producing Cells
Transpl Int, 37, 11900
DOI 10.3389/ti.2024.11900, PubMed 38304198
Publications 2023
Adipose-Derived Stromal Cells Preserve Pancreatic Islet Function in a Transplantable 3D Bioprinted Scaffold
Adv Healthc Mater, 12 (32), e2300640
DOI 10.1002/adhm.202300640, PubMed 37781993
Intracorneal Implantation of 3D Bioprinted Scaffolds Containing Mesenchymal Stromal Cells Using Femtosecond-Laser-Assisted Intrastromal Keratoplasty
Macromol Biosci, 23 (7), e2200422
DOI 10.1002/mabi.202200422, PubMed 36729619
Decidual stromal cells for the treatment of severe COVID-19 ARDS
Intensive Care Med, 49 (12), 1552-1554
DOI 10.1007/s00134-023-07262-x, PubMed 37968285
Quantitative chemometric phenotyping of three-dimensional liver organoids by Raman spectral imaging
Cell Rep Methods, 3 (4), 100440
DOI 10.1016/j.crmeth.2023.100440, PubMed 37159662
Global proteomics reveals insulin abundance as a marker of human islet homeostasis alterations
Acta Physiol (Oxf), 239 (2), e14037
DOI 10.1111/apha.14037, PubMed 37621186
Simultaneous LC-MS determination of glucose regulatory peptides secreted by stem cell-derived islet organoids
Electrophoresis, 44 (21-22), 1682-1697
DOI 10.1002/elps.202300095, PubMed 37574258
Autologous endothelialisation by the stromal vascular fraction on laminin-bioconjugated nanocellulose-alginate scaffolds
Biomed Mater, 18 (4)
DOI 10.1088/1748-605X/acdebb, PubMed 37321229
The Relevance of Advanced Therapy Medicinal Products in the Field of Transplantation and the Need for Academic Research Access: Overcoming Bottlenecks and Claiming a New Time
Transpl Int, 36, 11633
DOI 10.3389/ti.2023.11633, PubMed 37822447
Response to Comment on Carrasco et al. Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells. Diabetes 2022;71:862-869
Diabetes, 72 (5), e3-e4
DOI 10.2337/dbi23-0007, PubMed 37146277
Publications 2022
A Worldwide Survey of Activities and Practices in Clinical Islet of Langerhans Transplantation
Transpl Int, 35, 10507
DOI 10.3389/ti.2022.10507, PubMed 36033644
The Tankyrase Inhibitor OM-153 Demonstrates Antitumor Efficacy and a Therapeutic Window in Mouse Models
Cancer Res Commun, 2 (4), 233-245
DOI 10.1158/2767-9764.CRC-22-0027, PubMed 36873622
Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells
Diabetes, 71 (4), 862-869
DOI 10.2337/db20-1279, PubMed 35043148
Editorial: Beta-Cell Fate: From Gene Circuits to Disease Mechanisms
Front Genet, 13, 822440
DOI 10.3389/fgene.2022.822440, PubMed 35281817
"Organ-in-a-Column" Coupled On-line with Liquid Chromatography-Mass Spectrometry
Anal Chem, 94 (50), 17677-17684
DOI 10.1021/acs.analchem.2c04530, PubMed 36484723
Determination of insulin secretion from stem cell-derived islet organoids with liquid chromatography-tandem mass spectrometry
J Chromatogr B Analyt Technol Biomed Life Sci, 1215, 123577
DOI 10.1016/j.jchromb.2022.123577, PubMed 36542899
International Survey of Clinical Monitoring Practices in Pancreas and Islet Transplantation
Transplantation, 106 (8), 1647-1655
DOI 10.1097/TP.0000000000004058, PubMed 35019897
Publications 2021
Tissue Engineering Strategies for Improving Beta Cell Transplantation Outcome
Curr. Transplant. Rep., 8 (3), 205-219
DOI 10.1007/s40472-021-00333-2
Mini-organs forum: how to advance organoid technology to organ transplant community
Transpl Int, 34 (9), 1588-1593
DOI 10.1111/tri.13988, PubMed 34448263
Treatment of COVID-19 Pneumonia: the Case for Placenta-derived Cell Therapy
Stem Cell Rev Rep, 17 (1), 63-70
DOI 10.1007/s12015-020-10004-x, PubMed 32696426
Chronically Elevated Exogenous Glucose Elicits Antipodal Effects on the Proteome Signature of Differentiating Human iPSC-Derived Pancreatic Progenitors
Int J Mol Sci, 22 (7)
DOI 10.3390/ijms22073698, PubMed 33918250
Patient selection for islet or solid organ pancreas transplantation: experiences from a multidisciplinary outpatient-clinic approach
Endocr Connect, 10 (2), 230-239
DOI 10.1530/EC-20-0519, PubMed 33544090
US food and drug administration (FDA) panel endorses islet cell treatment for type 1 diabetes: A pyrrhic victory?
Transpl Int, 34 (7), 1182-1186
DOI 10.1111/tri.13930, PubMed 34048106
The long noncoding RNA TUNAR modulates Wnt signaling and regulates human β-cell proliferation
Am J Physiol Endocrinol Metab, 320 (4), E846-E857
DOI 10.1152/ajpendo.00335.2020, PubMed 33682459
Publications 2020
Pancreas-on-a-Chip Technology for Transplantation Applications
Curr Diab Rep, 20 (12), 72
DOI 10.1007/s11892-020-01357-1, PubMed 33206261
Inhibition of the prostaglandin D2-GPR44/DP2 axis improves human islet survival and function
Diabetologia, 63 (7), 1355-1367
DOI 10.1007/s00125-020-05138-z, PubMed 32350565
Proteomic Profiling Reveals the Ambivalent Character of the Mesenchymal Stem Cell Secretome: Assessing the Effect of Preconditioned Media on Isolated Human Islets
Cell Transplant, 29, 963689720952332
DOI 10.1177/0963689720952332, PubMed 33150790
In vivo hyperglycaemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress
Acta Physiol (Oxf), 228 (4), e13433
DOI 10.1111/apha.13433, PubMed 31872528
In vivo Environment Swiftly Restricts Human Pancreatic Progenitors Toward Mono-Hormonal Identity via a HNF1A/HNF4A Mechanism
Front Cell Dev Biol, 8, 109
DOI 10.3389/fcell.2020.00109, PubMed 32161757
Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling
Sci Rep, 10 (1), 414
DOI 10.1038/s41598-019-57305-x, PubMed 31942009
Heterogeneity of Human Pancreatic Islet Isolation Around Europe: Results of a Survey Study
Transplantation, 104 (1), 190-196
DOI 10.1097/TP.0000000000002777, PubMed 31365472
Publications 2019
Comparing the Effects of the mTOR Inhibitors Azithromycin and Rapamycin on In Vitro Expanded Regulatory T Cells
Cell Transplant, 28 (12), 1603-1613
DOI 10.1177/0963689719872488, PubMed 31512504
The Effect of Wnt Pathway Modulators on Human iPSC-Derived Pancreatic Beta Cell Maturation
Front Endocrinol (Lausanne), 10, 293
DOI 10.3389/fendo.2019.00293, PubMed 31139151
Publications 2018
Interleukin-22 reverses human islet dysfunction and apoptosis triggered by hyperglycemia and LIGHT
J Mol Endocrinol, 60 (3), 171-183
DOI 10.1530/JME-17-0182, PubMed 29330151
Calcium: A Crucial Potentiator for Efficient Enzyme Digestion of the Human Pancreas
Cell Transplant, 27 (7), 1031-1038
DOI 10.1177/0963689718779350, PubMed 29945463
β Cell Replacement Therapy: The Next 10 Years
Transplantation, 102 (2), 215-229
DOI 10.1097/TP.0000000000001937, PubMed 28885496
NLRP3 inflammasome mediates oxidative stress-induced pancreatic islet dysfunction
Am J Physiol Endocrinol Metab, 315 (5), E912-E923
DOI 10.1152/ajpendo.00461.2017, PubMed 30016155
Publications 2017
Glial cell-line derived neurotrophic factor protects human islets from nutrient deprivation and endoplasmic reticulum stress induced apoptosis
Sci Rep, 7 (1), 1575
DOI 10.1038/s41598-017-01805-1, PubMed 28484241
Hyperoxia reduces insulin release and induces mitochondrial dysfunction with possible implications for hyperoxic treatment of neonates
Physiol Rep, 5 (19)
DOI 10.14814/phy2.13447, PubMed 29038359
Human Adipose-Derived Mesenchymal Stem Cells Respond to Short-Term Hypoxia by Secreting Factors Beneficial for Human Islets In Vitro and Potentiate Antidiabetic Effect In Vivo
Cell Med, 9 (3), 103-116
DOI 10.3727/215517917X693401, PubMed 28713640
Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells
Sci Rep, 7 (1), 4780
DOI 10.1038/s41598-017-04979-w, PubMed 28684784
Publications 2016
Culture at low glucose up-regulates mitochondrial function in pancreatic β cells with accompanying effects on viability
Islets, 8 (6), 165-176
DOI 10.1080/19382014.2016.1246637, PubMed 27763807
LIGHT/TNFSF14 is increased in patients with type 2 diabetes mellitus and promotes islet cell dysfunction and endothelial cell inflammation in vitro
Diabetologia, 59 (10), 2134-44
DOI 10.1007/s00125-016-4036-y, PubMed 27421726
Treatment with Tacrolimus and Sirolimus Reveals No Additional Adverse Effects on Human Islets In Vitro Compared to Each Drug Alone but They Are Reduced by Adding Glucocorticoids
J Diabetes Res, 2016, 4196460
DOI 10.1155/2016/4196460, PubMed 26885529
Cost and clinical outcome of islet transplantation in Norway 2010-2015
Clin Transplant, 31 (1)
DOI 10.1111/ctr.12871, PubMed 27862341
Publications 2015
Mitochondrial Respiration in Insulin-Producing β-Cells: General Characteristics and Adaptive Effects of Hypoxia
PLoS One, 10 (9), e0138558
DOI 10.1371/journal.pone.0138558, PubMed 26401848
Intracellular sirolimus concentration is reduced by tacrolimus in human pancreatic islets in vitro
Transpl Int, 28 (10), 1152-61
DOI 10.1111/tri.12617, PubMed 26046470
The effects of exendin-4 treatment on graft failure: an animal study using a novel re-vascularized minimal human islet transplant model
PLoS One, 10 (3), e0121204
DOI 10.1371/journal.pone.0121204, PubMed 25793295
Graft function 1 year after pregnancy in an islet-transplanted patient
Transpl Int, 28 (10), 1235-9
DOI 10.1111/tri.12596, PubMed 25903157
Publications 2014
Interleukin-10 increases reverse cholesterol transport in macrophages through its bidirectional interaction with liver X receptor α
Biochem Biophys Res Commun, 450 (4), 1525-30
DOI 10.1016/j.bbrc.2014.07.036, PubMed 25035925
Publications 2013
Thioredoxin interacting protein is a potential regulator of glucose and energy homeostasis in endogenous Cushing's syndrome
PLoS One, 8 (5), e64247
DOI 10.1371/journal.pone.0064247, PubMed 23691179
Anakinra and tocilizumab enhance survival and function of human islets during culture: implications for clinical islet transplantation
Cell Transplant, 23 (10), 1199-211
DOI 10.3727/096368913X667529, PubMed 23635711
The effect of hepatic progenitor cells on experimental hepatocellular carcinoma in the regenerating liver
Scand J Gastroenterol, 49 (1), 99-108
DOI 10.3109/00365521.2013.854406, PubMed 24188385
Publications 2012
Plasma lipoproteins and preeclampsia in women with type 1 diabetes: a prospective study
J Clin Endocrinol Metab, 97 (5), 1752-62
DOI 10.1210/jc.2011-3255, PubMed 22438226
RAF-targeted therapy for hepatocellular carcinoma in the regenerating liver
J Surg Oncol, 107 (4), 393-401
DOI 10.1002/jso.23224, PubMed 22927239
Reduced soluble receptor for advanced glycation end-products (sRAGE) scavenger capacity precedes pre-eclampsia in Type 1 diabetes
BJOG, 119 (12), 1512-20
DOI 10.1111/j.1471-0528.2012.03463.x, PubMed 22900949
Publications 2011
Activin A levels are associated with abnormal glucose regulation in patients with myocardial infarction: potential counteracting effects of activin A on inflammation
Diabetes, 60 (5), 1544-51
DOI 10.2337/db10-1493, PubMed 21464440
Serum carotenoids and fat-soluble vitamins in women with type 1 diabetes and preeclampsia: a longitudinal study
Diabetes Care, 34 (6), 1258-64
DOI 10.2337/dc10-2145, PubMed 21498785
Publications 2010
Resolvin E1 reduces proinflammatory markers in human pancreatic islets in vitro
Exp Clin Endocrinol Diabetes, 118 (4), 237-44
DOI 10.1055/s-0029-1241825, PubMed 20119897
Publications 2009
The synthetic liver X receptor agonist GW3965 reduces tissue factor production and inflammatory responses in human islets in vitro
Diabetologia, 52 (7), 1352-62
DOI 10.1007/s00125-009-1366-z, PubMed 19415233
Associations between body composition, circulating interleukin-1 receptor antagonist, osteocalcin, and insulin metabolism in active acromegaly
J Clin Endocrinol Metab, 95 (1), 361-8
DOI 10.1210/jc.2009-0422, PubMed 19880791
Associations between Body Composition, Circulating Interleukin-1 Receptor Antagonist, Osteocalcin, and Insulin Metabolism in Active Acromegaly
Endocr Rev, 30 (7), 927
DOI 10.1210/edrv.30.7.9997, PubMed 28199500
Publications 2008
Glucocorticoids reduce pro-inflammatory cytokines and tissue factor in vitro and improve function of transplanted human islets in vivo
Transpl Int, 21 (7), 669-78
DOI 10.1111/j.1432-2277.2008.00664.x, PubMed 18346012
Sustained reversal of diabetes following islet transplantation to striated musculature in the rat
J Surg Res, 160 (1), 145-54
DOI 10.1016/j.jss.2008.11.009, PubMed 19394966
Publications 2006
Role of interleukin-10 in atherogenesis and plaque stabilization
Future Cardiol, 2 (1), 75-83
DOI 10.2217/14796678.2.1.75, PubMed 19804134
Enhanced T-cell expression of RANK ligand in acute coronary syndrome: possible role in plaque destabilization
Arterioscler Thromb Vasc Biol, 26 (4), 857-63
DOI 10.1161/01.ATV.0000204334.48195.6a, PubMed 16424351
Human macrophage function in the pathogenesis of atherosclerosis
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 379, 1 b. (flere pag.)
BIBSYS 060366060, ISBN 82-8072-213-0
Increased levels of neutrophil-activating peptide-2 in acute coronary syndromes: possible role of platelet-mediated vascular inflammation
J Am Coll Cardiol, 48 (8), 1591-9
DOI 10.1016/j.jacc.2006.06.060, PubMed 17045893
Publications 2005
Enhanced plasma levels of LIGHT in unstable angina: possible pathogenic role in foam cell formation and thrombosis
Circulation, 112 (14), 2121-9
DOI 10.1161/CIRCULATIONAHA.105.544676, PubMed 16186421
Publications 2004
Interleukin-10 enhances the oxidized LDL-induced foam cell formation of macrophages by antiapoptotic mechanisms
J Lipid Res, 46 (2), 211-9
DOI 10.1194/jlr.M400324-JLR200, PubMed 15547296
Potential anti-inflammatory role of activin A in acute coronary syndromes
J Am Coll Cardiol, 44 (2), 369-75
DOI 10.1016/j.jacc.2004.03.069, PubMed 15261933
Publications 2003
Hyperhomocysteinemic subjects have enhanced expression of lectin-like oxidized LDL receptor-1 in mononuclear cells
J Nutr, 133 (11), 3588-91
DOI 10.1093/jn/133.11.3588, PubMed 14608078
8-isoprostane increases expression of interleukin-8 in human macrophages through activation of mitogen-activated protein kinases
Cardiovasc Res, 59 (4), 945-54
DOI 10.1016/s0008-6363(03)00538-8, PubMed 14553834