Hanne Scholz

  • Senior scientist, MSc, PhD
  • +47 23073526, +47 97514215
 

Original articles

Legøy TA, Vethe H, Abadpour S, Strand BL, Scholz H, Paulo JA, Ræder H, Ghila L, Chera S (2020)
Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling
Sci Rep, 10 (1), 414
DOI 10.1038/s41598-019-57305-x, PubMed 31942009

Nano R, Kerr-Conte JA, Scholz H, Engelse M, Karlsson M, Saudek F, Bosco D, Antonioli B, Bertuzzi F, Johnson PRV, Ludwing B, Ling Z, De Paep DL, Keymeulen B, Pattou F, Berney T, Korsgren O, de Koning E, Piemonti L (2020)
Heterogeneity of Human Pancreatic Islet Isolation Around Europe: Results of a Survey Study
Transplantation, 104 (1), 190-196
DOI 10.1097/TP.0000000000002777, PubMed 31365472

Legøy TA, Ghila L, Vethe H, Abadpour S, Mathisen AF, Paulo JA, Scholz H, Raeder H, Chera S (2019)
In vivo hyperglycaemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress
Acta Physiol (Oxf), e13433
DOI 10.1111/apha.13433, PubMed 31872528

Bergström M, Müller M, Karlsson M, Scholz H, Vethe NT, Korsgren O (2019)
Comparing the Effects of the mTOR Inhibitors Azithromycin and Rapamycin on In Vitro Expanded Regulatory T Cells
Cell Transplant, 28 (12), 1603-1613
DOI 10.1177/0963689719872488, PubMed 31512504

Vethe H, Ghila L, Berle M, Hoareau L, Haaland ØA, Scholz H, Paulo JA, Chera S, Ræder H (2019)
The Effect of Wnt Pathway Modulators on Human iPSC-Derived Pancreatic Beta Cell Maturation
Front Endocrinol (Lausanne), 10, 293
DOI 10.3389/fendo.2019.00293, PubMed 31139151

Sokolova M, Sahraoui A, Høyem M, Øgaard J, Lien E, Aukrust P, Yndestad A, Ranheim T, Scholz H (2018)
NLRP3 inflammasome mediates oxidative stress-induced pancreatic islet dysfunction
Am J Physiol Endocrinol Metab, 315 (5), E912-E923
DOI 10.1152/ajpendo.00461.2017, PubMed 30016155

Eich T, Ståhle M, Gustafsson B, Horneland R, Lempinen M, Lundgren T, Rafael E, Tufveson G, Zur-Mühlen BV, Olerud J, Scholz H, Korsgren O (2018)
Calcium: A Crucial Potentiator for Efficient Enzyme Digestion of the Human Pancreas
Cell Transplant, 27 (7), 1031-1038
DOI 10.1177/0963689718779350, PubMed 29945463

Abadpour S, Halvorsen B, Sahraoui A, Korsgren O, Aukrust P, Scholz H (2018)
Interleukin-22 reverses human islet dysfunction and apoptosis triggered by hyperglycemia and LIGHT
J Mol Endocrinol, 60 (3), 171-183
DOI 10.1530/JME-17-0182, PubMed 29330151

Hals I, Ohki T, Singh R, Ma Z, Björklund A, Balasuriya C, Scholz H, Grill V (2017)
Hyperoxia reduces insulin release and induces mitochondrial dysfunction with possible implications for hyperoxic treatment of neonates
Physiol Rep, 5 (19)
DOI 10.14814/phy2.13447, PubMed 29038359

Vethe H, Bjørlykke Y, Ghila LM, Paulo JA, Scholz H, Gygi SP, Chera S, Ræder H (2017)
Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells
Sci Rep, 7 (1), 4780
DOI 10.1038/s41598-017-04979-w, PubMed 28684784

Abadpour S, Göpel SO, Schive SW, Korsgren O, Foss A, Scholz H (2017)
Glial cell-line derived neurotrophic factor protects human islets from nutrient deprivation and endoplasmic reticulum stress induced apoptosis
Sci Rep, 7 (1), 1575
DOI 10.1038/s41598-017-01805-1, PubMed 28484241

Schive SW, Mirlashari MR, Hasvold G, Wang M, Josefsen D, Gullestad HP, Korsgren O, Foss A, Kvalheim G, Scholz H (2017)
Human Adipose-Derived Mesenchymal Stem Cells Respond to Short-Term Hypoxia by Secreting Factors Beneficial for Human Islets In Vitro and Potentiate Antidiabetic Effect In Vivo
Cell Med, 9 (3), 103-116
DOI 10.3727/215517917X693401, PubMed 28713640

Schive SW, Foss A, Sahraoui A, Kloster-Jensen K, Hafsahl G, Kvalheim G, Lundgren T, von Zur-Mühlen B, Felldin M, Rafael E, Lempinen M, Korsgren O, Jenssen TG, Mishra V, Scholz H (2016)
Cost and clinical outcome of islet transplantation in Norway 2010-2015
Clin Transplant, 31 (1)
DOI 10.1111/ctr.12871, PubMed 27862341

Hals IK, Singh R, Ma Z, Scholz H, Björklund A, Grill V (2016)
Culture at low glucose up-regulates mitochondrial function in pancreatic β cells with accompanying effects on viability
Islets, 8 (6), 165-176
DOI 10.1080/19382014.2016.1246637, PubMed 27763807

Halvorsen B, Santilli F, Scholz H, Sahraoui A, Gulseth HL, Wium C, Lattanzio S, Formoso G, Di Fulvio P, Otterdal K, Retterstøl K, Holven KB, Gregersen I, Stavik B, Bjerkeli V, Michelsen AE, Ueland T, Liani R, Davi G, Aukrust P (2016)
LIGHT/TNFSF14 is increased in patients with type 2 diabetes mellitus and promotes islet cell dysfunction and endothelial cell inflammation in vitro
Diabetologia, 59 (10), 2134-44
DOI 10.1007/s00125-016-4036-y, PubMed 27421726

Kloster-Jensen K, Sahraoui A, Vethe NT, Korsgren O, Bergan S, Foss A, Scholz H (2016)
Treatment with Tacrolimus and Sirolimus Reveals No Additional Adverse Effects on Human Islets In Vitro Compared to Each Drug Alone but They Are Reduced by Adding Glucocorticoids
J Diabetes Res, 2016, 4196460
DOI 10.1155/2016/4196460, PubMed 26885529

Hals IK, Bruerberg SG, Ma Z, Scholz H, Björklund A, Grill V (2015)
Mitochondrial Respiration in Insulin-Producing β-Cells: General Characteristics and Adaptive Effects of Hypoxia
PLoS One, 10 (9), e0138558
DOI 10.1371/journal.pone.0138558, PubMed 26401848

Kloster-Jensen K, Vethe NT, Bremer S, Abadpour S, Korsgren O, Foss A, Bergan S, Scholz H (2015)
Intracellular sirolimus concentration is reduced by tacrolimus in human pancreatic islets in vitro
Transpl Int, 28 (10), 1152-61
DOI 10.1111/tri.12617, PubMed 26046470

Schive SW, Scholz H, Sahraoui A, Kloster-Jensen K, Hafsahl G, Korsgren O, Foss A, Jenssen TG (2015)
Graft function 1 year after pregnancy in an islet-transplanted patient
Transpl Int, 28 (10), 1235-9
DOI 10.1111/tri.12596, PubMed 25903157

Sahraoui A, Winzell MS, Gorman T, Smith DM, Skrtic S, Hoeyem M, Abadpour S, Johansson L, Korsgren O, Foss A, Scholz H (2015)
The effects of exendin-4 treatment on graft failure: an animal study using a novel re-vascularized minimal human islet transplant model
PLoS One, 10 (3), e0121204
DOI 10.1371/journal.pone.0121204, PubMed 25793295

Halvorsen B, Holm S, Yndestad A, Scholz H, Sagen EL, Nebb H, Holven KB, Dahl TB, Aukrust P (2014)
Interleukin-10 increases reverse cholesterol transport in macrophages through its bidirectional interaction with liver X receptor α
Biochem Biophys Res Commun, 450 (4), 1525-30
DOI 10.1016/j.bbrc.2014.07.036, PubMed 25035925

Shi JH, Scholz H, Huitfeldt HS, Line PD (2013)
The effect of hepatic progenitor cells on experimental hepatocellular carcinoma in the regenerating liver
Scand J Gastroenterol, 49 (1), 99-108
DOI 10.3109/00365521.2013.854406, PubMed 24188385

Sahraoui A, Kloster-Jensen K, Ueland T, Korsgren O, Foss A, Scholz H (2013)
Anakinra and tocilizumab enhance survival and function of human islets during culture: implications for clinical islet transplantation
Cell Transplant, 23 (10), 1199-211
DOI 10.3727/096368913X667529, PubMed 23635711

Lekva T, Bollerslev J, Sahraoui A, Scholz H, Bøyum H, Evang JA, Godang K, Aukrust P, Ueland T (2013)
Thioredoxin interacting protein is a potential regulator of glucose and energy homeostasis in endogenous Cushing's syndrome
PLoS One, 8 (5), e64247
DOI 10.1371/journal.pone.0064247, PubMed 23691179

Shi JH, Liu SZ, Wierød L, Scholz H, Anmarkrud JA, Huitfeldt HS, Zhang SJ, Line PD (2012)
RAF-targeted therapy for hepatocellular carcinoma in the regenerating liver
J Surg Oncol, 107 (4), 393-401
DOI 10.1002/jso.23224, PubMed 22927239

Yu Y, Hanssen KF, Kalyanaraman V, Chirindel A, Jenkins AJ, Nankervis AJ, Torjesen PA, Scholz H, Henriksen T, Lorentzen B, Garg SK, Menard MK, Hammad SM, Scardo JA, Stanley JR, Wu M, Basu A, Aston CE, Lyons TJ (2012)
Reduced soluble receptor for advanced glycation end-products (sRAGE) scavenger capacity precedes pre-eclampsia in Type 1 diabetes
BJOG, 119 (12), 1512-20
DOI 10.1111/j.1471-0528.2012.03463.x, PubMed 22900949

Basu A, Alaupovic P, Wu M, Jenkins AJ, Yu Y, Nankervis AJ, Hanssen KF, Scholz H, Henriksen T, Lorentzen B, Clausen T, Garg SK, Menard MK, Hammad SM, Scardo JA, Stanley JR, Dashti A, Aston CE, Lyons TJ (2012)
Plasma lipoproteins and preeclampsia in women with type 1 diabetes: a prospective study
J Clin Endocrinol Metab, 97 (5), 1752-62
DOI 10.1210/jc.2011-3255, PubMed 22438226

Azar M, Basu A, Jenkins AJ, Nankervis AJ, Hanssen KF, Scholz H, Henriksen T, Garg SK, Hammad SM, Scardo JA, Aston CE, Lyons TJ (2011)
Serum carotenoids and fat-soluble vitamins in women with type 1 diabetes and preeclampsia: a longitudinal study
Diabetes Care, 34 (6), 1258-64
DOI 10.2337/dc10-2145, PubMed 21498785

Andersen GØ, Ueland T, Knudsen EC, Scholz H, Yndestad A, Sahraoui A, Smith C, Lekva T, Otterdal K, Halvorsen B, Seljeflot I, Aukrust P (2011)
Activin A levels are associated with abnormal glucose regulation in patients with myocardial infarction: potential counteracting effects of activin A on inflammation
Diabetes, 60 (5), 1544-51
DOI 10.2337/db10-1493, PubMed 21464440

Lund T, Mangsbo SM, Scholz H, Gjorstrup P, Tötterman TH, Korsgren O, Foss A (2010)
Resolvin E1 reduces proinflammatory markers in human pancreatic islets in vitro
Exp Clin Endocrinol Diabetes, 118 (4), 237-44
DOI 10.1055/s-0029-1241825, PubMed 20119897

Ueland T, Fougner SL, Godang K, Lekva T, Schurgers LJ, Scholz H, Halvorsen B, Schreiner T, Aukrust PL, Bollerslev J (2009)
Associations between Body Composition, Circulating Interleukin-1 Receptor Antagonist, Osteocalcin, and Insulin Metabolism in Active Acromegaly
Endocr Rev, 30 (7), 927
DOI 10.1210/edrv.30.7.9997, PubMed 28199500

Ueland T, Fougner SL, Godang K, Lekva T, Schurgers LJ, Scholz H, Halvorsen B, Schreiner T, Aukrust P, Bollerslev J (2009)
Associations between body composition, circulating interleukin-1 receptor antagonist, osteocalcin, and insulin metabolism in active acromegaly
J Clin Endocrinol Metab, 95 (1), 361-8
DOI 10.1210/jc.2009-0422, PubMed 19880791

Scholz H, Lund T, Dahle MK, Collins JL, Korsgren O, Wang JE, Foss A (2009)
The synthetic liver X receptor agonist GW3965 reduces tissue factor production and inflammatory responses in human islets in vitro
Diabetologia, 52 (7), 1352-62
DOI 10.1007/s00125-009-1366-z, PubMed 19415233

Lund T, Korsgren O, Aursnes IA, Scholz H, Foss A (2008)
Sustained reversal of diabetes following islet transplantation to striated musculature in the rat
J Surg Res, 160 (1), 145-54
DOI 10.1016/j.jss.2008.11.009, PubMed 19394966

Lund T, Fosby B, Korsgren O, Scholz H, Foss A (2008)
Glucocorticoids reduce pro-inflammatory cytokines and tissue factor in vitro and improve function of transplanted human islets in vivo
Transpl Int, 21 (7), 669-78
DOI 10.1111/j.1432-2277.2008.00664.x, PubMed 18346012

Smith C, Damås JK, Otterdal K, Øie E, Sandberg WJ, Yndestad A, Waehre T, Scholz H, Endresen K, Olofsson PS, Halvorsen B, Gullestad L, Frøland SS, Hansson GK, Aukrust P (2006)
Increased levels of neutrophil-activating peptide-2 in acute coronary syndromes: possible role of platelet-mediated vascular inflammation
J Am Coll Cardiol, 48 (8), 1591-9
DOI 10.1016/j.jacc.2006.06.060, PubMed 17045893

Sandberg WJ, Yndestad A, Øie E, Smith C, Ueland T, Ovchinnikova O, Robertson AK, Müller F, Semb AG, Scholz H, Andreassen AK, Gullestad L, Damås JK, Frøland SS, Hansson GK, Halvorsen B, Aukrust P (2006)
Enhanced T-cell expression of RANK ligand in acute coronary syndrome: possible role in plaque destabilization
Arterioscler Thromb Vasc Biol, 26 (4), 857-63
DOI 10.1161/01.ATV.0000204334.48195.6a, PubMed 16424351

Halvorsen B, Waehre T, Scholz H, Damås JK, Yndestad A, Aukrust P (2006)
Role of interleukin-10 in atherogenesis and plaque stabilization
Future Cardiol, 2 (1), 75-83
DOI 10.2217/14796678.2.1.75, PubMed 19804134

Scholz H, Sandberg W, Damås JK, Smith C, Andreassen AK, Gullestad L, Frøland SS, Yndestad A, Aukrust P, Halvorsen B (2005)
Enhanced plasma levels of LIGHT in unstable angina: possible pathogenic role in foam cell formation and thrombosis
Circulation, 112 (14), 2121-9
DOI 10.1161/CIRCULATIONAHA.105.544676, PubMed 16186421

Halvorsen B, Waehre T, Scholz H, Clausen OP, von der Thüsen JH, Müller F, Heimli H, Tonstad S, Hall C, Frøland SS, Biessen EA, Damås JK, Aukrust P (2004)
Interleukin-10 enhances the oxidized LDL-induced foam cell formation of macrophages by antiapoptotic mechanisms
J Lipid Res, 46 (2), 211-9
DOI 10.1194/jlr.M400324-JLR200, PubMed 15547296

Smith C, Yndestad A, Halvorsen B, Ueland T, Waehre T, Otterdal K, Scholz H, Endresen K, Gullestad L, Frøland SS, Damås JK, Aukrust P (2004)
Potential anti-inflammatory role of activin A in acute coronary syndromes
J Am Coll Cardiol, 44 (2), 369-75
DOI 10.1016/j.jacc.2004.03.069, PubMed 15261933

Holven KB, Scholz H, Halvorsen B, Aukrust P, Ose L, Nenseter MS (2003)
Hyperhomocysteinemic subjects have enhanced expression of lectin-like oxidized LDL receptor-1 in mononuclear cells
J Nutr, 133 (11), 3588-91
DOI 10.1093/jn/133.11.3588, PubMed 14608078

Scholz H, Yndestad A, Damås JK, Waehre T, Tonstad S, Aukrust P, Halvorsen B (2003)
8-isoprostane increases expression of interleukin-8 in human macrophages through activation of mitogen-activated protein kinases
Cardiovasc Res, 59 (4), 945-54
DOI 10.1016/s0008-6363(03)00538-8, PubMed 14553834

Review articles

Schuetz C, Anazawa T, Cross SE, Labriola L, Meier RPH, Redfield RR, Scholz H, Stock PG, Zammit NW, IPITA YIC Young Investigator Committee (2018)
β Cell Replacement Therapy: The Next 10 Years
Transplantation, 102 (2), 215-229
DOI 10.1097/TP.0000000000001937, PubMed 28885496

Theses

Scholz H (2006)
Human macrophage function in the pathogenesis of atherosclerosis
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 379, 1 b. (flere pag.)
BIBSYS 060366060, ISBN 82-8072-213-0

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