Publications 2024

Teles-Reis J, Jain A, Liu D, Khezri R, Micheli S, Gomez AA, Dillard C, Rusten TE (2024)
EyaHOST, a modular genetic system for investigation of intercellular and tumor-host interactions in Drosophila melanogaster
bioRxiv
DOI 10.1101/2024.09.06.611647, PubMed 39314415

Publications 2023

Javed R, Jain A, Duque T, Hendrix E, Paddar MA, Khan S, Claude-Taupin A, Jia J, Allers L, Wang F, Mudd M, Timmins G, Lidke K, Rusten TE, Akepati PR, He Y, Reggiori F, Eskelinen EL, Deretic V (2023)
Mammalian ATG8 proteins maintain autophagosomal membrane integrity through ESCRTs
EMBO J, 42 (14), e112845
DOI 10.15252/embj.2022112845, PubMed 37272163

Migliano SM, Schultz SW, Wenzel EM, Takáts S, Liu D, Mørk S, Tan KW, Rusten TE, Raiborg C, Stenmark H (2023)
Removal of hypersignaling endosomes by simaphagy
Autophagy, 20 (4), 769-791
DOI 10.1080/15548627.2023.2267958, PubMed 37840274

Publications 2022

Holland P, Quintana EM, Khezri R, Schoborg TA, Rusten TE (2022)
Computed tomography with segmentation and quantification of individual organs in a D. melanogaster tumor model
Sci Rep, 12 (1), 2056
DOI 10.1038/s41598-022-05991-5, PubMed 35136137

Khezri R, Rusten TE (2022)
Autophagy power expands: fuse those cells!
EMBO J, 41 (12), e111424
DOI 10.15252/embj.2022111424, PubMed 35561082

Lobert VH, Skardal ML, Malerød L, Simensen JE, Algra HA, Andersen AN, Fleischer T, Enserink HA, Liestøl K, Heath JK, Rusten TE, Stenmark HA (2022)
PHLPP1 regulates CFTR activity and lumen expansion through AMPK
Development, 149 (20)
DOI 10.1242/dev.200955, PubMed 35997536

Mehto S, Jena KK, Yadav R, Priyadarsini S, Samal P, Krishna S, Dhar K, Jain A, Chauhan NR, Murmu KC, Bal R, Sahu R, Jaiswal P, Sahoo BS, Patnaik S, Kufer TA, Rusten TE, Chauhan S, Prasad P, Chauhan S (2022)
Selective autophagy of RIPosomes maintains innate immune homeostasis during bacterial infection
EMBO J, 41 (23), e111289
DOI 10.15252/embj.2022111289, PubMed 36221902

Publications 2021

Dillard C, Reis JGT, Rusten TE (2021)
Ras^V12; scrib^-/- Tumors: A Cooperative Oncogenesis Model Fueled by Tumor/Host Interactions
Int J Mol Sci, 22 (16)
DOI 10.3390/ijms22168873, PubMed 34445578

Holland P, Hagopian WM, Jahren AH, Rusten TE (2021)
Natural abundance isotope ratios to differentiate sources of carbon used during tumor growth in vivo
BMC Biol, 19 (1), 85
DOI 10.1186/s12915-021-01012-5, PubMed 33966633

Khezri R, Holland P, Schoborg TA, Abramovich I, Takáts S, Dillard C, Jain A, O'Farrell F, Schultz SW, Hagopian WM, Quintana EM, Ng R, Katheder NS, Rahman MM, Teles Reis JG, Brech A, Jasper H, Rusan NM, Jahren AH, Gottlieb E, Rusten TE (2021)
Host autophagy mediates organ wasting and nutrient mobilization for tumor growth
EMBO J, 40 (18), e107336
DOI 10.15252/embj.2020107336, PubMed 34309071

Kumar S, Javed R, Mudd M, Pallikkuth S, Lidke KA, Jain A, Tangavelou K, Gudmundsson SR, Ye C, Rusten TE, Anonsen JH, Lystad AH, Claude-Taupin A, Simonsen A, Salemi M, Phinney B, Li J, Guo LW, Bradfute SB, Timmins GS, Eskelinen EL, Deretic V (2021)
Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes
Cell, 184 (24), 5950-5969.e22
DOI 10.1016/j.cell.2021.10.017, PubMed 34741801

Publications 2020

Jena KK, Mehto S, Nath P, Chauhan NR, Sahu R, Dhar K, Das SK, Kolapalli SP, Murmu KC, Jain A, Krishna S, Sahoo BS, Chattopadhyay S, Rusten TE, Prasad P, Chauhan S, Chauhan S (2020)
Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon response
EMBO Rep, 21 (9), e50051
DOI 10.15252/embr.202050051, PubMed 32715615

Kolapalli SP, Sahu R, Chauhan NR, Jena KK, Mehto S, Das SK, Jain A, Rout M, Dash R, Swain RK, Lee DY, Rusten TE, Chauhan S, Chauhan S (2020)
RNA-Binding RING E3-Ligase DZIP3/hRUL138 Stabilizes Cyclin D1 to Drive Cell-Cycle and Cancer Progression
Cancer Res, 81 (2), 315-331
DOI 10.1158/0008-5472.CAN-20-1871, PubMed 33067265

Kumar S, Jain A, Choi SW, da Silva GPD, Allers L, Mudd MH, Peters RS, Anonsen JH, Rusten TE, Lazarou M, Deretic V (2020)
Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens
Nat Cell Biol, 22 (8), 973-985
DOI 10.1038/s41556-020-0549-1, PubMed 32753672

Kumar S, Jain A, Choi SW, da Silva GPD, Allers L, Mudd MH, Peters RS, Anonsen JH, Rusten TE, Lazarou M, Deretic V (2020)
Author Correction: Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens
Nat Cell Biol, 22 (10), 1286
DOI 10.1038/s41556-020-0574-0, PubMed 32788721

Kumar S, Jain A, Choi SW, Peixoto Duarte da Silva G, Allers L, Mudd MH, Peters RS, Anonsen JH, Rusten TE, Lazarou M, Deretic V (2020)
Mammalian Atg8-family proteins are upstream regulators of the lysosomalsystem by controlling MTOR and TFEB
Autophagy, 16 (12), 2305-2306
DOI 10.1080/15548627.2020.1837423, PubMed 33070669

Publications 2019

Dillard C, Rusten TE (2019)
Cell Competition Triggers Suicide by Autophagy
Dev Cell, 51 (1), 4-5
DOI 10.1016/j.devcel.2019.09.014, PubMed 31593651

Fang EF, Hou Y, Lautrup S, Jensen MB, Yang B, SenGupta T, Caponio D, Khezri R, Demarest TG, Aman Y, Figueroa D, Morevati M, Lee HJ, Kato H, Kassahun H, Lee JH, Filippelli D, Okur MN, Mangerich A, Croteau DL, Maezawa Y, Lyssiotis CA, Tao J, Yokote K, Rusten TE et al. (2019)
NAD⁺ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
Nat Commun, 10 (1), 5284
DOI 10.1038/s41467-019-13172-8, PubMed 31754102

Khezri R, Rusten TE (2019)
Autophagy and Tumorigenesis in Drosophila
Adv Exp Med Biol, 1167, 113-127
DOI 10.1007/978-3-030-23629-8_7, PubMed 31520352

Khezri R, Rusten TE (2019)
Correction to: Autophagy and Tumorigenesis in Drosophila
Adv Exp Med Biol, 1167, C1
DOI 10.1007/978-3-030-23629-8_15, PubMed 33306185

Kumar S, Gu Y, Abudu YP, Bruun JA, Jain A, Farzam F, Mudd M, Anonsen JH, Rusten TE, Kasof G, Ktistakis N, Lidke KA, Johansen T, Deretic V (2019)
Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation
Dev Cell, 49 (1), 130-144.e6
DOI 10.1016/j.devcel.2019.01.027, PubMed 30827897

Publications 2018

Kumar S, Jain A, Farzam F, Jia J, Gu Y, Choi SW, Mudd MH, Claude-Taupin A, Wester MJ, Lidke KA, Rusten TE, Deretic V (2018)
Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins
J Cell Biol, 217 (3), 997-1013
DOI 10.1083/jcb.201708039, PubMed 29420192

Publications 2017

Katheder NS, Khezri R, O'Farrell F, Schultz SW, Jain A, Rahman MM, Schink KO, Theodossiou TA, Johansen T, Juhász G, Bilder D, Brech A, Stenmark H, Rusten TE (2017)
Microenvironmental autophagy promotes tumour growth
Nature, 541 (7637), 417-420
DOI 10.1038/nature20815, PubMed 28077876

Katheder NS, Rusten TE (2017)
Microenvironment and tumors-a nurturing relationship
Autophagy, 13 (7), 1241-1243
DOI 10.1080/15548627.2017.1310361, PubMed 28632995

O'Farrell F, Lobert VH, Sneeggen M, Jain A, Katheder NS, Wenzel EM, Schultz SW, Tan KW, Brech A, Stenmark H, Rusten TE (2017)
Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation
Nat Cell Biol, 19 (12), 1412-1423
DOI 10.1038/ncb3631, PubMed 29084199

Publications 2016

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM et al. (2016)
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Autophagy, 12 (1), 1-222
DOI 10.1080/15548627.2015.1100356, PubMed 26799652

Schmid MR, Anderl I, Vo HT, Valanne S, Yang H, Kronhamn J, Rämet M, Rusten TE, Hultmark D (2016)
Genetic Screen in Drosophila Larvae Links ird1 Function to Toll Signaling in the Fat Body and Hemocyte Motility
PLoS One, 11 (7), e0159473
DOI 10.1371/journal.pone.0159473, PubMed 27467079

Publications 2015

Jain A, Rusten TE, Katheder N, Elvenes J, Bruun JA, Sjøttem E, Lamark T, Johansen T (2015)
p62/Sequestosome-1, Autophagy-related Gene 8, and Autophagy in Drosophila Are Regulated by Nuclear Factor Erythroid 2-related Factor 2 (NRF2), Independent of Transcription Factor TFEB
J Biol Chem, 290 (24), 14945-62
DOI 10.1074/jbc.M115.656116, PubMed 25931115

Publications 2014

Morelli E, Ginefra P, Mastrodonato V, Beznoussenko GV, Rusten TE, Bilder D, Stenmark H, Mironov AA, Vaccari T (2014)
Multiple functions of the SNARE protein Snap29 in autophagy, endocytic, and exocytic trafficking during epithelial formation in Drosophila
Autophagy, 10 (12), 2251-68
DOI 10.4161/15548627.2014.981913, PubMed 25551675

Publications 2013

Knævelsrud H, Søreng K, Raiborg C, Håberg K, Rasmuson F, Brech A, Liestøl K, Rusten TE, Stenmark H, Neufeld TP, Carlsson SR, Simonsen A (2013)
Membrane remodeling by the PX-BAR protein SNX18 promotes autophagosome formation
J Cell Biol, 202 (2), 331-49
DOI 10.1083/jcb.201205129, PubMed 23878278

Martens S, Rusten TE, Kraft C (2013)
Autophagy at sea
Autophagy, 9 (9), 1286-91
DOI 10.4161/auto.25838, PubMed 23917436

O Farrell F, Rusten TE, Stenmark H (2013)
Phosphoinositide 3-kinases as accelerators and brakes of autophagy
FEBS J, 280 (24), 6322-37
DOI 10.1111/febs.12486, PubMed 23953235

O'Farrell F, Wang S, Katheder N, Rusten TE, Samakovlis C (2013)
Two-tiered control of epithelial growth and autophagy by the insulin receptor and the ret-like receptor, stitcher
PLoS Biol, 11 (7), e1001612
DOI 10.1371/journal.pbio.1001612, PubMed 23935447

Publications 2012

Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A et al. (2012)
Guidelines for the use and interpretation of assays for monitoring autophagy
Autophagy, 8 (4), 445-544
DOI 10.4161/auto.19496, PubMed 22966490

Oppelt A, Lobert VH, Haglund K, Mackey AM, Rameh LE, Liestøl K, Schink KO, Pedersen NM, Wenzel EM, Haugsten EM, Brech A, Rusten TE, Stenmark H, Wesche J (2012)
Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration
EMBO Rep, 14 (1), 57-64
DOI 10.1038/embor.2012.183, PubMed 23154468

Publications 2011

Rusten TE, Vaccari T, Stenmark H (2011)
Shaping development with ESCRTs
Nat Cell Biol, 14 (1), 38-45
DOI 10.1038/ncb2381, PubMed 22193162

Publications 2010

Nezis IP, Shravage BV, Sagona AP, Lamark T, Bjørkøy G, Johansen T, Rusten TE, Brech A, Baehrecke EH, Stenmark H (2010)
Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis
J Cell Biol, 190 (4), 523-31
DOI 10.1083/jcb.201002035, PubMed 20713604

Rusten TE, Stenmark H (2010)
p62, an autophagy hero or culprit?
Nat Cell Biol, 12 (3), 207-9
DOI 10.1038/ncb0310-207, PubMed 20190829

Sagona AP, Nezis IP, Pedersen NM, Liestøl K, Poulton J, Rusten TE, Skotheim RI, Raiborg C, Stenmark H (2010)
PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody
Nat Cell Biol, 12 (4), 362-71
DOI 10.1038/ncb2036, PubMed 20208530

Publications 2009

Nezis IP, Lamark T, Velentzas AD, Rusten TE, Bjørkøy G, Johansen T, Papassideri IS, Stravopodis DJ, Margaritis LH, Stenmark H, Brech A (2009)
Cell death during Drosophila melanogaster early oogenesis is mediated through autophagy
Autophagy, 5 (3), 298-302
DOI 10.4161/auto.5.3.7454, PubMed 19066465

Rodahl LM, Haglund K, Sem-Jacobsen C, Wendler F, Vincent JP, Lindmo K, Rusten TE, Stenmark H (2009)
Disruption of Vps4 and JNK function in Drosophila causes tumour growth
PLoS One, 4 (2), e4354
DOI 10.1371/journal.pone.0004354, PubMed 19194501

Rusten TE, Stenmark H (2009)
How do ESCRT proteins control autophagy?
J Cell Sci, 122 (Pt 13), 2179-83
DOI 10.1242/jcs.050021, PubMed 19535733

Vaccari T, Rusten TE, Menut L, Nezis IP, Brech A, Stenmark H, Bilder D (2009)
Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants
J Cell Sci, 122 (Pt 14), 2413-23
DOI 10.1242/jcs.046391, PubMed 19571114

Publications 2008

Lindmo K, Brech A, Finley KD, Gaumer S, Contamine D, Rusten TE, Stenmark H (2008)
The PI 3-kinase regulator Vps15 is required for autophagic clearance of protein aggregates
Autophagy, 4 (4), 500-6
DOI 10.4161/auto.5829, PubMed 18326940

Morrison HA, Dionne H, Rusten TE, Brech A, Fisher WW, Pfeiffer BD, Celniker SE, Stenmark H, Bilder D (2008)
Regulation of early endosomal entry by the Drosophila tumor suppressors Rabenosyn and Vps45
Mol Biol Cell, 19 (10), 4167-76
DOI 10.1091/mbc.e08-07-0716, PubMed 18685079

Nezis IP, Simonsen A, Sagona AP, Finley K, Gaumer S, Contamine D, Rusten TE, Stenmark H, Brech A (2008)
Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain
J Cell Biol, 180 (6), 1065-71
DOI 10.1083/jcb.200711108, PubMed 18347073

Rusten TE, Filimonenko M, Rodahl LM, Stenmark H, Simonsen A (2008)
ESCRTing autophagic clearance of aggregating proteins
Autophagy, 4 (2), 233-236
DOI 10.4161/auto.5396

Rusten TE, Simonsen A (2008)
ESCRT functions in autophagy and associated disease
Cell Cycle, 7 (9), 1166-72
DOI 10.4161/cc.7.9.5784, PubMed 18418046

Publications 2007

Haglund K, Rusten TE, Stenmark H (2007)
Aberrant receptor signaling and trafficking as mechanisms in oncogenesis
Crit Rev Oncog, 13 (1), 39-74
DOI 10.1615/critrevoncog.v13.i1.20, PubMed 17956217

Hughes T, Rusten TE (2007)
Origin and evolution of self-consumption: autophagy
Adv Exp Med Biol, 607, 111-8
DOI 10.1007/978-0-387-74021-8_9, PubMed 17977463

Rusten TE, Stenmark H (2007)
Developmental biology: moonlighting at the pole
Nature, 445 (7127), 497-9
DOI 10.1038/445497a, PubMed 17268460

Rusten TE, Vaccari T, Lindmo K, Rodahl LM, Nezis IP, Sem-Jacobsen C, Wendler F, Vincent JP, Brech A, Bilder D, Stenmark H (2007)
ESCRTs and Fab1 regulate distinct steps of autophagy
Curr Biol, 17 (20), 1817-25
DOI 10.1016/j.cub.2007.09.032, PubMed 17935992

Simonsen A, Cumming RC, Lindmo K, Galaviz V, Cheng S, Rusten TE, Finley KD (2007)
Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles
Genetics, 176 (2), 1283-97
DOI 10.1534/genetics.106.065011, PubMed 17435236

Publications 2006

Lindmo K, Simonsen A, Brech A, Finley K, Rusten TE, Stenmark H (2006)
A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body
Exp Cell Res, 312 (11), 2018-27
DOI 10.1016/j.yexcr.2006.03.002, PubMed 16600212

Rusten TE, Rodahl LM, Pattni K, Englund C, Samakovlis C, Dove S, Brech A, Stenmark H (2006)
Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors
Mol Biol Cell, 17 (9), 3989-4001
DOI 10.1091/mbc.e06-03-0239, PubMed 16837550

Rusten TE, Stenmark H (2006)
Analyzing phosphoinositides and their interacting proteins
Nat Methods, 3 (4), 251-8
DOI 10.1038/nmeth867, PubMed 16554828

Publications 2004

Rusten TE, Lindmo K, Juhász G, Sass M, Seglen PO, Brech A, Stenmark H (2004)
Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway
Dev Cell, 7 (2), 179-92
DOI 10.1016/j.devcel.2004.07.005, PubMed 15296715

Publications 2003

Kolpakova E, Rusten TE, Olsnes S (2003)
Characterization and tissue expression of acidic fibroblast growth factor binding protein homologue in Drosophila melanogaster
Gene, 310, 185-91
DOI 10.1016/s0378-1119(03)00550-x, PubMed 12801646

Raiborg C, Rusten TE, Stenmark H (2003)
Protein sorting into multivesicular endosomes
Curr Opin Cell Biol, 15 (4), 446-55
DOI 10.1016/s0955-0674(03)00080-2, PubMed 12892785

Publications 2002

Cantera R, Lüer K, Rusten TE, Barrio R, Kafatos FC, Technau GM (2002)
Mutations in spalt cause a severe but reversible neurodegenerative phenotype in the embryonic central nervous system of Drosophila melanogaster
Development, 129 (24), 5577-86
DOI 10.1242/dev.00158, PubMed 12421699

Rusten TE (2002)
A study of the role of the zinc finger transcription factor spalt and TGF-β-signaling in Drosophila embryonic PNS development
Det europeiske laboratorium for molekylærbiologi, Heidelberg, 80 s.
BIBSYS 030170923

Rusten TE, Cantera R, Kafatos FC, Barrio R (2002)
The role of TGF beta signaling in the formation of the dorsal nervous system is conserved between Drosophila and chordates
Development, 129 (15), 3575-84
DOI 10.1242/dev.129.15.3575, PubMed 12117808

Publications 2001

Rusten TE, Cantera R, Urban J, Technau G, Kafatos FC, Barrio R (2001)
Spalt modifies EGFR-mediated induction of chordotonal precursors in the embryonic PNS of Drosophila promoting the development of oenocytes
Development, 128 (5), 711-22
DOI 10.1242/dev.128.5.711, PubMed 11171396