Publications 2022

Mehto S, Jena KK, Yadav R, Priyadarsini S, Samal P, Krishna S, Dhar K, Jain A, Chauhan NR, Murmu KC, Bal R, Sahu R, Jaiswal P, Sahoo BS, Patnaik S, Kufer TA, Rusten TE, Chauhan S, Prasad P, Chauhan S (2022)
Selective autophagy of RIPosomes maintains innate immune homeostasis during bacterial infection
EMBO J, 41 (23), e111289
DOI 10.15252/embj.2022111289, PubMed 36221902

Publications 2021

Khezri R, Holland P, Schoborg TA, Abramovich I, Takáts S, Dillard C, Jain A, O'Farrell F, Schultz SW, Hagopian WM, Quintana EM, Ng R, Katheder NS, Rahman MM, Teles Reis JG, Brech A, Jasper H, Rusan NM, Jahren AH, Gottlieb E, Rusten TE (2021)
Host autophagy mediates organ wasting and nutrient mobilization for tumor growth
EMBO J, 40 (18), e107336
DOI 10.15252/embj.2020107336, PubMed 34309071

Kumar S, Javed R, Mudd M, Pallikkuth S, Lidke KA, Jain A, Tangavelou K, Gudmundsson SR, Ye C, Rusten TE, Anonsen JH, Lystad AH, Claude-Taupin A, Simonsen A, Salemi M, Phinney B, Li J, Guo LW, Bradfute SB, Timmins GS, Eskelinen EL, Deretic V (2021)
Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes
Cell, 184 (24), 5950-5969.e22
DOI 10.1016/j.cell.2021.10.017, PubMed 34741801

Wirth M, Mouilleron S, Zhang W, Sjøttem E, Abudu YP, Jain A, Olsvik HL, Bruun JA, Razi M, Jefferies HBJ, Lee R, Joshi D, O'Reilly N, Johansen T, Tooze SA (2021)
Corrigendum to Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity
J Mol Biol, 433 (15), 167049
DOI 10.1016/j.jmb.2021.167049, PubMed 34052024

Wirth M, Mouilleron S, Zhang W, Sjøttem E, Princely Abudu Y, Jain A, Lauritz Olsvik H, Bruun JA, Razi M, Jefferies HBJ, Lee R, Joshi D, O'Reilly N, Johansen T, Tooze SA (2021)
Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity
J Mol Biol, 433 (13), 166987
DOI 10.1016/j.jmb.2021.166987, PubMed 33845085

Publications 2020

Jacomin AC, Gohel R, Hussain Z, Varga A, Maruzs T, Eddison M, Sica M, Jain A, Moffat KG, Johansen T, Jenny A, Juhasz G, Nezis IP (2020)
Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in Drosophila
Life Sci Alliance, 4 (2)
DOI 10.26508/lsa.202000965, PubMed 33318080

Jacomin AC, Petridi S, Di Monaco M, Bhujabal Z, Jain A, Mulakkal NC, Palara A, Powell EL, Chung B, Zampronio C, Jones A, Cameron A, Johansen T, Nezis IP (2020)
Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila
Cell Rep, 31 (8), 107695
DOI 10.1016/j.celrep.2020.107695, PubMed 32460019

Jena KK, Mehto S, Nath P, Chauhan NR, Sahu R, Dhar K, Das SK, Kolapalli SP, Murmu KC, Jain A, Krishna S, Sahoo BS, Chattopadhyay S, Rusten TE, Prasad P, Chauhan S, Chauhan S (2020)
Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon response
EMBO Rep, 21 (9), e50051
DOI 10.15252/embr.202050051, PubMed 32715615

Kolapalli SP, Sahu R, Chauhan NR, Jena KK, Mehto S, Das SK, Jain A, Rout M, Dash R, Swain RK, Lee DY, Rusten TE, Chauhan S, Chauhan S (2020)
RNA-Binding RING E3-Ligase DZIP3/hRUL138 Stabilizes Cyclin D1 to Drive Cell-Cycle and Cancer Progression
Cancer Res, 81 (2), 315-331
DOI 10.1158/0008-5472.CAN-20-1871, PubMed 33067265

Kumar S, Jain A, Choi SW, da Silva GPD, Allers L, Mudd MH, Peters RS, Anonsen JH, Rusten TE, Lazarou M, Deretic V (2020)
Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens
Nat Cell Biol, 22 (8), 973-985
DOI 10.1038/s41556-020-0549-1, PubMed 32753672

Kumar S, Jain A, Choi SW, da Silva GPD, Allers L, Mudd MH, Peters RS, Anonsen JH, Rusten TE, Lazarou M, Deretic V (2020)
Author Correction: Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens
Nat Cell Biol, 22 (10), 1286
DOI 10.1038/s41556-020-0574-0, PubMed 32788721

Kumar S, Jain A, Choi SW, Peixoto Duarte da Silva G, Allers L, Mudd MH, Peters RS, Anonsen JH, Rusten TE, Lazarou M, Deretic V (2020)
Mammalian Atg8-family proteins are upstream regulators of the lysosomalsystem by controlling MTOR and TFEB
Autophagy, 16 (12), 2305-2306
DOI 10.1080/15548627.2020.1837423, PubMed 33070669

Vietri M, Schultz SW, Bellanger A, Jones CM, Petersen LI, Raiborg C, Skarpen E, Pedurupillay CRJ, Kjos I, Kip E, Timmer R, Jain A, Collas P, Knorr RL, Grellscheid SN, Kusumaatmaja H, Brech A, Micci F, Stenmark H, Campsteijn C (2020)
Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation
Nat Cell Biol, 22 (7), 856-867
DOI 10.1038/s41556-020-0537-5, PubMed 32601372

Publications 2019

Kumar S, Gu Y, Abudu YP, Bruun JA, Jain A, Farzam F, Mudd M, Anonsen JH, Rusten TE, Kasof G, Ktistakis N, Lidke KA, Johansen T, Deretic V (2019)
Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation
Dev Cell, 49 (1), 130-144.e6
DOI 10.1016/j.devcel.2019.01.027, PubMed 30827897

Lie-Jensen A, Ivanauskiene K, Malerød L, Jain A, Tan KW, Laerdahl JK, Liestøl K, Stenmark H, Haglund K (2019)
Centralspindlin Recruits ALIX to the Midbody during Cytokinetic Abscission in Drosophila via a Mechanism Analogous to Virus Budding
Curr Biol, 29 (20), 3538-3548.e7
DOI 10.1016/j.cub.2019.09.025, PubMed 31607533

Mehto S, Jena KK, Nath P, Chauhan S, Kolapalli SP, Das SK, Sahoo PK, Jain A, Taylor GA, Chauhan S (2019)
The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy
Mol Cell, 73 (3), 429-445.e7
DOI 10.1016/j.molcel.2018.11.018, PubMed 30612879

Overå KS, Garcia-Garcia J, Bhujabal Z, Jain A, Øvervatn A, Larsen KB, Deretic V, Johansen T, Lamark T, Sjøttem E (2019)
TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62/SQSTM1
J Cell Sci, 132 (23)
DOI 10.1242/jcs.236596, PubMed 31685529

Pölönen P, Jawahar Deen A, Leinonen HM, Jyrkkänen HK, Kuosmanen S, Mononen M, Jain A, Tuomainen T, Pasonen-Seppänen S, Hartikainen JM, Mannermaa A, Nykter M, Tavi P, Johansen T, Heinäniemi M, Levonen AL (2019)
Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma
Oncogene, 38 (50), 7473-7490
DOI 10.1038/s41388-019-0956-6, PubMed 31444413

Publications 2018

Fusco C, Mandriani B, Di Rienzo M, Micale L, Malerba N, Cocciadiferro D, Sjøttem E, Augello B, Squeo GM, Pellico MT, Jain A, Johansen T, Fimia GM, Merla G (2018)
TRIM50 regulates Beclin 1 proautophagic activity
Biochim Biophys Acta Mol Cell Res, 1865 (6), 908-919
DOI 10.1016/j.bbamcr.2018.03.011, PubMed 29604308

Kumar S, Jain A, Farzam F, Jia J, Gu Y, Choi SW, Mudd MH, Claude-Taupin A, Wester MJ, Lidke KA, Rusten TE, Deretic V (2018)
Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins
J Cell Biol, 217 (3), 997-1013
DOI 10.1083/jcb.201708039, PubMed 29420192

Publications 2017

Katheder NS, Khezri R, O'Farrell F, Schultz SW, Jain A, Rahman MM, Schink KO, Theodossiou TA, Johansen T, Juhász G, Bilder D, Brech A, Stenmark H, Rusten TE (2017)
Microenvironmental autophagy promotes tumour growth
Nature, 541 (7637), 417-420
DOI 10.1038/nature20815, PubMed 28077876

Kimura T, Jain A, Choi SW, Mandell MA, Johansen T, Deretic V (2017)
TRIM-directed selective autophagy regulates immune activation
Autophagy, 13 (5), 989-990
DOI 10.1080/15548627.2016.1154254, PubMed 26983397

Kimura T, Jia J, Claude-Taupin A, Kumar S, Choi SW, Gu Y, Mudd M, Dupont N, Jiang S, Peters R, Farzam F, Jain A, Lidke KA, Adams CM, Johansen T, Deretic V (2017)
Cellular and molecular mechanism for secretory autophagy
Autophagy, 13 (6), 1084-1085
DOI 10.1080/15548627.2017.1307486, PubMed 28368721

Kumar S, Chauhan S, Jain A, Ponpuak M, Choi SW, Mudd M, Peters R, Mandell MA, Johansen T, Deretic V (2017)
Galectins and TRIMs directly interact and orchestrate autophagic response to endomembrane damage
Autophagy, 13 (6), 1086-1087
DOI 10.1080/15548627.2017.1307487, PubMed 28368693

Mandell MA, Jain A, Kumar S, Castleman MJ, Anwar T, Eskelinen EL, Johansen T, Prekeris R, Deretic V (2017)
Correction: TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation
J Cell Sci, 130 (6), 1194
DOI 10.1242/jcs.202499, PubMed 28298613

O'Farrell F, Lobert VH, Sneeggen M, Jain A, Katheder NS, Wenzel EM, Schultz SW, Tan KW, Brech A, Stenmark H, Rusten TE (2017)
Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation
Nat Cell Biol, 19 (12), 1412-1423
DOI 10.1038/ncb3631, PubMed 29084199

Tusco R, Jacomin AC, Jain A, Penman BS, Larsen KB, Johansen T, Nezis IP (2017)
Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses
Nat Commun, 8 (1), 1264
DOI 10.1038/s41467-017-01287-9, PubMed 29097655

Publications 2016

Chauhan S, Kumar S, Jain A, Ponpuak M, Mudd MH, Kimura T, Choi SW, Peters R, Mandell M, Bruun JA, Johansen T, Deretic V (2016)
TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis
Dev Cell, 39 (1), 13-27
DOI 10.1016/j.devcel.2016.08.003, PubMed 27693506

Kimura T, Jia J, Kumar S, Choi SW, Gu Y, Mudd M, Dupont N, Jiang S, Peters R, Farzam F, Jain A, Lidke KA, Adams CM, Johansen T, Deretic V (2016)
Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy
EMBO J, 36 (1), 42-60
DOI 10.15252/embj.201695081, PubMed 27932448

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM et al. (2016)
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Autophagy, 12 (1), 1-222
DOI 10.1080/15548627.2015.1100356, PubMed 26799652

Mandell MA, Jain A, Kumar S, Castleman MJ, Anwar T, Eskelinen EL, Johansen T, Prekeris R, Deretic V (2016)
TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation
J Cell Sci, 129 (19), 3562-3573
DOI 10.1242/jcs.190017, PubMed 27562068

Puvirajesinghe TM, Bertucci F, Jain A, Scerbo P, Belotti E, Audebert S, Sebbagh M, Lopez M, Brech A, Finetti P, Charafe-Jauffret E, Chaffanet M, Castellano R, Restouin A, Marchetto S, Collette Y, Gonçalvès A, Macara I, Birnbaum D, Kodjabachian L, Johansen T, Borg JP (2016)
Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer
Nat Commun, 7, 10318
DOI 10.1038/ncomms10318, PubMed 26754771

Publications 2015

Bertrand M, Petit V, Jain A, Amsellem R, Johansen T, Larue L, Codogno P, Beau I (2015)
SQSTM1/p62 regulates the expression of junctional proteins through epithelial-mesenchymal transition factors
Cell Cycle, 14 (3), 364-374
DOI 10.4161/15384101.2014.987619

Borel S, Robert-Hebmann V, Alfaisal J, Jain A, Faure M, Espert L, Chaloin L, Paillart JC, Johansen T, Biard-Piechaczyk M (2015)
HIV-1 viral infectivity factor interacts with microtubule-associated protein light chain 3 and inhibits autophagy
Aids, 29 (3), 275-286
DOI 10.1097/QAD.0000000000000554

Jain A, Rusten TE, Katheder N, Elvenes J, Bruun JA, Sjøttem E, Lamark T, Johansen T (2015)
p62/Sequestosome-1, Autophagy-related Gene 8, and Autophagy in Drosophila Are Regulated by Nuclear Factor Erythroid 2-related Factor 2 (NRF2), Independent of Transcription Factor TFEB
J Biol Chem, 290 (24), 14945-62
DOI 10.1074/jbc.M115.656116, PubMed 25931115

Kimura T, Jain A, Choi SW, Mandell MA, Schroder K, Johansen T, Deretic V (2015)
TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity
J. Cell Biol., 210 (6), 973-989
DOI 10.1083/jcb.201503023

Publications 2014

Mandell MA, Jain A, Arko-Mensah J, Chauhan S, Kimura T, Dinkins C, Silvestri G, Münch J, Kirchhoff F, Simonsen A, Wei Y, Levine B, Johansen T, Deretic V (2014)
TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition
Dev Cell, 30 (4), 394-409
DOI 10.1016/j.devcel.2014.06.013, PubMed 25127057

Mandell MA, Kimura T, Jain A, Johansen T, Deretic V (2014)
TRIM proteins regulate autophagy: TRIM5 is a selective autophagy receptor mediating HIV-1 restriction
Autophagy, 10 (12), 2387-+
DOI 10.4161/15548627.2014.984278

Publications 2012

Alemu EA, Lamark T, Torgersen KM, Birgisdottir AB, Larsen KB, Jain A, Olsvik H, Øvervatn A, Kirkin V, Johansen T (2012)
ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs
J Biol Chem, 287 (47), 39275-90
DOI 10.1074/jbc.M112.378109, PubMed 23043107

Publications 2010

Jain A, Lamark T, Sjøttem E, Larsen KB, Awuh JA, Øvervatn A, McMahon M, Hayes JD, Johansen T (2010)
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
J Biol Chem, 285 (29), 22576-91
DOI 10.1074/jbc.M110.118976, PubMed 20452972