
Ashish Jain
- Postdoc (University of Oslo); PhD
- +47 22 78 19 15
Publications 2020
Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila
Cell Rep, 31 (8), 107695
DOI 10.1016/j.celrep.2020.107695, PubMed 32460019
Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon response
EMBO Rep, 21 (9), e50051
DOI 10.15252/embr.202050051, PubMed 32715615
Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens
Nat Cell Biol, 22 (8), 973-985
DOI 10.1038/s41556-020-0549-1, PubMed 32753672
Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation
Nat Cell Biol, 22 (7), 856-867
DOI 10.1038/s41556-020-0537-5, PubMed 32601372
Publications 2019
Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation
Dev Cell, 49 (1), 130-144.e6
DOI 10.1016/j.devcel.2019.01.027, PubMed 30827897
Centralspindlin Recruits ALIX to the Midbody during Cytokinetic Abscission in Drosophila via a Mechanism Analogous to Virus Budding
Curr Biol, 29 (20), 3538-3548.e7
DOI 10.1016/j.cub.2019.09.025, PubMed 31607533
The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy
Mol Cell, 73 (3), 429-445.e7
DOI 10.1016/j.molcel.2018.11.018, PubMed 30612879
TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62/SQSTM1
J Cell Sci, 132 (23)
DOI 10.1242/jcs.236596, PubMed 31685529
Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma
Oncogene, 38 (50), 7473-7490
DOI 10.1038/s41388-019-0956-6, PubMed 31444413
Publications 2018
TRIM50 regulates Beclin 1 proautophagic activity
Biochim Biophys Acta Mol Cell Res, 1865 (6), 908-919
DOI 10.1016/j.bbamcr.2018.03.011, PubMed 29604308
Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins
J Cell Biol, 217 (3), 997-1013
DOI 10.1083/jcb.201708039, PubMed 29420192
Publications 2017
Microenvironmental autophagy promotes tumour growth
Nature, 541 (7637), 417-420
DOI 10.1038/nature20815, PubMed 28077876
TRIM-directed selective autophagy regulates immune activation
Autophagy, 13 (5), 989-990
DOI 10.1080/15548627.2016.1154254, PubMed 26983397
Cellular and molecular mechanism for secretory autophagy
Autophagy, 13 (6), 1084-1085
DOI 10.1080/15548627.2017.1307486, PubMed 28368721
Galectins and TRIMs directly interact and orchestrate autophagic response to endomembrane damage
Autophagy, 13 (6), 1086-1087
DOI 10.1080/15548627.2017.1307487, PubMed 28368693
Correction: TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation
J Cell Sci, 130 (6), 1194
DOI 10.1242/jcs.202499, PubMed 28298613
Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation
Nat Cell Biol, 19 (12), 1412-1423
DOI 10.1038/ncb3631, PubMed 29084199
Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses
Nat Commun, 8 (1), 1264
DOI 10.1038/s41467-017-01287-9, PubMed 29097655
Publications 2016
TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis
Dev Cell, 39 (1), 13-27
DOI 10.1016/j.devcel.2016.08.003, PubMed 27693506
Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy
EMBO J, 36 (1), 42-60
DOI 10.15252/embj.201695081, PubMed 27932448
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Autophagy, 12 (1), 1-222
DOI 10.1080/15548627.2015.1100356, PubMed 26799652
TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation
J Cell Sci, 129 (19), 3562-3573
DOI 10.1242/jcs.190017, PubMed 27562068
Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer
Nat Commun, 7, 10318
DOI 10.1038/ncomms10318, PubMed 26754771
Publications 2015
SQSTM1/p62 regulates the expression of junctional proteins through epithelial-mesenchymal transition factors
Cell Cycle, 14 (3), 364-374
HIV-1 viral infectivity factor interacts with microtubule-associated protein light chain 3 and inhibits autophagy
Aids, 29 (3), 275-286
p62/Sequestosome-1, Autophagy-related Gene 8, and Autophagy in Drosophila Are Regulated by Nuclear Factor Erythroid 2-related Factor 2 (NRF2), Independent of Transcription Factor TFEB
J Biol Chem, 290 (24), 14945-62
DOI 10.1074/jbc.M115.656116, PubMed 25931115
TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity
J. Cell Biol., 210 (6), 973-989
Publications 2014
TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition
Dev Cell, 30 (4), 394-409
DOI 10.1016/j.devcel.2014.06.013, PubMed 25127057
TRIM proteins regulate autophagy: TRIM5 is a selective autophagy receptor mediating HIV-1 restriction
Autophagy, 10 (12), 2387-+
Publications 2012
ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs
J Biol Chem, 287 (47), 39275-90
DOI 10.1074/jbc.M112.378109, PubMed 23043107
Publications 2010
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
J Biol Chem, 285 (29), 22576-91
DOI 10.1074/jbc.M110.118976, PubMed 20452972