Anita Langerød
- Senior scientist; PhD
- +47 22 78 13 76
Publications 2024
Impact of Prosigna test on adjuvant treatment decision in lymph node-negative early breast cancer-a prospective national multicentre study (EMIT-1)
ESMO Open, 9 (6), 103475
DOI 10.1016/j.esmoop.2024.103475, PubMed 38838499
Publications 2023
Obesity-associated changes in molecular biology of primary breast cancer
Nat Commun, 14 (1), 4418
DOI 10.1038/s41467-023-39996-z, PubMed 37479706
Publications 2022
Cis-regulatory mutations associate with transcriptional and post-transcriptional deregulation of gene regulatory programs in cancers
Nucleic Acids Res, 50 (21), 12131-12148
DOI 10.1093/nar/gkac1143, PubMed 36477895
Publications 2020
DNA copy number motifs are strong and independent predictors of survival in breast cancer
Commun Biol, 3 (1), 153
DOI 10.1038/s42003-020-0884-6, PubMed 32242091
Publications 2019
Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences
Nature, 566 (7742), E1
DOI 10.1038/s41586-019-0883-2, PubMed 30659290
Publications 2017
Recommended Guidelines for Validation, Quality Control, and Reporting of TP53 Variants in Clinical Practice
Cancer Res, 77 (6), 1250-1260
DOI 10.1158/0008-5472.CAN-16-2179, PubMed 28254861
Assessment of TP53 Polymorphisms and MDM2 SNP309 in Premenopausal Breast Cancer Risk
Hum Mutat, 38 (3), 265-268
DOI 10.1002/humu.23154, PubMed 27957778
TP53 Mutations in Breast and Ovarian Cancer
Cold Spring Harb Perspect Med, 7 (1)
DOI 10.1101/cshperspect.a026252, PubMed 27815305
The Longitudinal Transcriptional Response to Neoadjuvant Chemotherapy with and without Bevacizumab in Breast Cancer
Clin Cancer Res, 23 (16), 4662-4670
DOI 10.1158/1078-0432.CCR-17-0160, PubMed 28487444
Publications 2016
Landscape of somatic mutations in 560 breast cancer whole-genome sequences
Nature, 534 (7605), 47-54
DOI 10.1038/nature17676, PubMed 27135926
Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer
Cell Rep, 16 (7), 2032-46
DOI 10.1016/j.celrep.2016.07.028, PubMed 27498871
Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration
Nat Commun, 7, 12910
DOI 10.1038/ncomms12910, PubMed 27666519
Publications 2015
The Sub-Cellular Localization of WRAP53 Has Prognostic Impact in Breast Cancer
PLoS One, 10 (10), e0139965
DOI 10.1371/journal.pone.0139965, PubMed 26460974
Publications 2014
Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53
Mol Cancer Res, 13 (3), 493-501
DOI 10.1158/1541-7786.MCR-14-0387, PubMed 25351767
TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance
Clin Cancer Res, 20 (13), 3569-80
DOI 10.1158/1078-0432.CCR-13-2943, PubMed 24803582
Publications 2013
AMG 900, pan-Aurora kinase inhibitor, preferentially inhibits the proliferation of breast cancer cell lines with dysfunctional p53
Breast Cancer Res Treat, 141 (3), 397-408
DOI 10.1007/s10549-013-2702-z, PubMed 24091768
Publications 2012
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
Nature, 486 (7403), 346-52
DOI 10.1038/nature10983, PubMed 22522925
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
Cell, 148 (1-2), 244-58
DOI 10.1016/j.cell.2011.12.017, PubMed 22265415
Functional characterization of the 19q12 amplicon in grade III breast cancers
Breast Cancer Res, 14 (2), R53
DOI 10.1186/bcr3154, PubMed 22433433
Mutational processes molding the genomes of 21 breast cancers
Cell, 149 (5), 979-93
DOI 10.1016/j.cell.2012.04.024, PubMed 22608084
The life history of 21 breast cancers
Cell, 149 (5), 994-1007
DOI 10.1016/j.cell.2012.04.023, PubMed 22608083
AZGP1 and SPDEF mRNA expression differentiates breast carcinoma from ovarian serous carcinoma
Virchows Arch, 462 (2), 163-73
DOI 10.1007/s00428-012-1347-3, PubMed 23242172
The landscape of cancer genes and mutational processes in breast cancer
Nature, 486 (7403), 400-4
DOI 10.1038/nature11017, PubMed 22722201
Publications 2011
Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters
Nat Genet, 43 (7), 621-9
DOI 10.1038/ng.848, PubMed 21642992
Association of the germline TP53 R72P and MDM2 SNP309 variants with breast cancer survival in specific breast tumor subgroups
Breast Cancer Res Treat, 130 (2), 599-608
DOI 10.1007/s10549-011-1615-y, PubMed 21667122
Combining gene signatures improves prediction of breast cancer survival
PLoS One, 6 (3), e17845
DOI 10.1371/journal.pone.0017845, PubMed 21423775
Publications 2010
p53-Dependent repression of focal adhesion kinase in response to estradiol in breast cancer cell-lines
Cancer Lett, 300 (2), 215-24
DOI 10.1016/j.canlet.2010.10.008, PubMed 21071137
Epithelial-stromal interaction 1 (EPSTI1) substitutes for peritumoral fibroblasts in the tumor microenvironment
Am J Pathol, 176 (3), 1229-40
DOI 10.2353/ajpath.2010.090648, PubMed 20133812
BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations
BMC Cancer, 10, 654
DOI 10.1186/1471-2407-10-654, PubMed 21118481
Genomic architecture characterizes tumor progression paths and fate in breast cancer patients
Sci Transl Med, 2 (38), 38ra47
DOI 10.1126/scitranslmed.3000611, PubMed 20592421
Publications 2009
Focal amplification and oncogene dependency of GAB2 in breast cancer
Oncogene, 29 (5), 774-9
DOI 10.1038/onc.2009.364, PubMed 19881546
Somatic mutation databases as tools for molecular epidemiology and molecular pathology of cancer: proposed guidelines for improving data collection, distribution, and integration
Hum Mutat, 30 (3), 275-82
DOI 10.1002/humu.20832, PubMed 19006239
Complex landscapes of somatic rearrangement in human breast cancer genomes
Nature, 462 (7276), 1005-10
DOI 10.1038/nature08645, PubMed 20033038
Full sequencing of TP53 identifies identical mutations within in situ and invasive components in breast cancer suggesting clonal evolution
Mol Oncol, 3 (3), 214-9
DOI 10.1016/j.molonc.2009.03.001, PubMed 19403344
Publications 2008
CAMK1D amplification implicated in epithelial-mesenchymal transition in basal-like breast cancer
Mol Oncol, 2 (4), 327-39
DOI 10.1016/j.molonc.2008.09.004, PubMed 19383354
Human papillomavirus DNA and e6/e7 mRNA status in relation to survival of patients treated for cervical squamous cell carcinoma
Open Virol J, 2, 74-81
DOI 10.2174/1874357900802010074, PubMed 19440467
EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer
Breast Cancer Res, 10 (6), R109
DOI 10.1186/bcr2214, PubMed 19099573
Publications 2007
Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas
Breast Cancer Res, 9 (1), R5
DOI 10.1186/bcr1637, PubMed 17224074
Common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, and susceptibility to breast cancer
Int J Cancer, 121 (11), 2532-8
DOI 10.1002/ijc.22985, PubMed 17683073
Common genetic variation in GATA-binding protein 3 and differential susceptibility to breast cancer by estrogen receptor alpha tumor status
Cancer Epidemiol Biomarkers Prev, 16 (11), 2269-75
DOI 10.1158/1055-9965.EPI-07-0449, PubMed 18006915
Discovery and validation of breast cancer subtypes (vol 8, pg 101, 2007)
BMC Genomics, 8, 101
DOI 10.1186/1471-2164-8-101
Cancer stem cells.
In Breast cancer – diagnostics and treatment, Novartis, 12, 136-144
PublikaID 32
TP53 mutation status and gene expression profiles are powerful prognostic markers of breast cancer
Breast Cancer Res, 9 (3), R30
DOI 10.1186/bcr1675, PubMed 17504517
Publications 2006
Expression of full-length p53 and its isoform Deltap53 in breast carcinomas in relation to mutation status and clinical parameters
Mol Cancer, 5, 47
DOI 10.1186/1476-4598-5-47, PubMed 17054774
Discovery and validation of breast cancer subtypes
BMC Genomics, 7, 231
DOI 10.1186/1471-2164-7-231, PubMed 16965636
The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer
Clin Cancer Res, 12 (4), 1157-67
DOI 10.1158/1078-0432.CCR-05-1029, PubMed 16489069
Publications 2005
Gene expression profiling of breast cancer in relation to estrogen receptor status and estrogen-metabolizing enzymes: clinical implications
Clin Cancer Res, 11 (2 Pt 2), 878s-83s
PubMed 15701881
Molecular profiling of breast cancer: from single gene variants to whole genome expression patterns
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 283, 1 b. (flere pag.)
BIBSYS 051013681, ISBN 82-8072-649-7
Publications 2004
Mutation of GATA3 in human breast tumors
Oncogene, 23 (46), 7669-78
DOI 10.1038/sj.onc.1207966, PubMed 15361840
Different gene expression patterns in invasive lobular and ductal carcinomas of the breast
Mol Biol Cell, 15 (6), 2523-36
DOI 10.1091/mbc.e03-11-0786, PubMed 15034139
Publications 2003
Overexpression of cyclin A overrides the effect of p53 alterations in breast cancer patients with long follow-up time
Breast Cancer Res Treat, 80 (2), 199-206
DOI 10.1023/A:1024527220362, PubMed 12908823
BUB1 infrequently mutated in human breast carcinomas
Hum Mutat, 22 (5), 420
DOI 10.1002/humu.9194, PubMed 14517964
Publications 2002
High frequency of skewed X inactivation in young breast cancer patients
J Med Genet, 39 (1), 30-3
DOI 10.1136/jmg.39.1.30, PubMed 11826021
The TP53 codon 72 polymorphism may affect the function of TP53 mutations in breast carcinomas but not in colorectal carcinomas
Cancer Epidemiol Biomarkers Prev, 11 (12), 1684-8
PubMed 12496062
Publications 1999
BRCA1 screening in patients with a family history of breast or ovarian cancer
Genet Test, 3 (2), 223-6
DOI 10.1089/gte.1999.3.223, PubMed 10464672
Molecular studies of breast cancer: evaluation of TTGE in mutation screening of BRCA1 and TP53 haplotypes in relation to LOH and mutation
A. Langerød, [Trondheim], 95, 16, 19 bl.
BIBSYS 000542210
Publications 1998
p53 polymorphism and risk of cervical cancer
Nature, 396 (6711), 530-1; author reply 532
DOI 10.1038/25034, PubMed 9859987
Publications 1997
Temporal Temperature Gradient Gel Electrophoresis on the DCode™ System A Comparison to DGGE and CDGE in Mutation Screening
In Bio Rad Bulletin, BioRad, 2133, 12-13
PublikaID 33