Are Martin Holm

  • Consultant pulmonologist and associate university professor; MD, PhD
  • +47 23072029

Main focus area: Airway inflammation in general and lung transplantation

Curriculum vitae 

EDUCATION/EMPLOYMENT: MEDICAL

1993: Cand.med. (MD) Freiburg, Germany

1994: Physician authorisation

1994-2000: Gen.internal medicine: Aker University Hospital, Bærum Hospital, Rikshospitalet University Hospital (Section of Clinical Immunology and Infectious Diseases, Medical Department, Department of Respiratory Medicine)

2000-2004: Research fellow Research Institute for Internal Medicine, Rikshospitalet

2004-2009: Physician Dept. Respiratory Medicine, Rikshospitalet. Main area: lung transplantation

2006: Clinical speciality General Internal Medicine approved

2009-    Associate professor medical faculty, University of Oslo and Physician Dept. Respiratory Medicine, Rikshospitalet. Main area: lung transplantation and pulmonary immunology

SCIENTIFICAL MERIT

1998: Bed-side teaching of medical students at Section of Infectious Diseases, Ullevål University Hospital (6 months)

2006: Dr.med. (PhD) thesis, title: "T cell dysfunction in Common Variable Immunodeficiency"

Review and scientific education

Reviewed papers in Blood, Br J Haematol, Clin Exp Immunol, Hematologica, Immunobiology, Immunology, Allergol&Immunopatol.

Reviewed grant applications for Primary Immunodeficiency Association, UK

 

 

Publications 2020

Holm AM, Immer F, Benden C (2020)
Lung allocation for transplant: The European perspective
Clin Transplant, 34 (7), e13883
DOI 10.1111/ctr.13883, PubMed 32294267

Publications 2018

Stang J, Sikkeland LIB, Tufvesson E, Holm AM, Stensrud T, Carlsen KH (2018)
The Role of Airway Inflammation and Bronchial Hyperresponsiveness in Athlete's Asthma
Med Sci Sports Exerc, 50 (4), 659-666
DOI 10.1249/MSS.0000000000001478, PubMed 29189668

Publications 2017

Floeystad HK, Holm A, Sandvik L, Vestrheim DF, Brandsaeter B, Berild D (2017)
Increased long-term mortality after survival of invasive pneumococcal disease: a population-based study
Infect Dis (Lond), 49 (5), 365-372
DOI 10.1080/23744235.2016.1271997, PubMed 28095723

Lindberg A, Holm AM, Hilberg O, Harju T, Vestbo J, Foronjy R, Harju T, Nurmos NI, Karvonen H, Lappi-Blanco E, Skold M, Lehtonen S, Kaarteenaho R, Backman H, Christensen VL, Rustoen T, Cooper BA, Miaskowski C, Henriksen AH, Bentsen SB, Holm AM, Andersson M, Waatevik M, Johannessen A, Real FG et al. (2017)
VII Scandinavian Copd Research Symposium, Holmenkollen, Oslo 18th-19th November 2016
EUR. CLIN. RESPIR. J., 5 1, 1401867
DOI 10.1080/20018525.2017.1401867

Ruttens D, Verleden SE, Bijnens EM, Winckelmans E, Gottlieb J, Warnecke G, Meloni F, Morosini M, Van Der Bij W, Verschuuren EA, Sommerwerck U, Weinreich G, Kamler M, Roman A, Gomez-Olles S, Berastegui C, Benden C, Holm AM, Iversen M, Schultz HH, Luijk B, Oudijk EJ, Kwakkel-van Erp JM, Jaksch P, Klepetko W et al. (2017)
An association of particulate air pollution and traffic exposure with mortality after lung transplantation in Europe
Eur Respir J, 49 (1)
DOI 10.1183/13993003.00484-2016, PubMed 27836956

Publications 2016

Christensen VL, Holm AM, Cooper B, Paul SM, Miaskowski C, Rustøen T (2016)
Differences in Symptom Burden Among Patients With Moderate, Severe, or Very Severe Chronic Obstructive Pulmonary Disease
J Pain Symptom Manage, 51 (5), 849-59
DOI 10.1016/j.jpainsymman.2015.12.324, PubMed 26899820

Christensen VL, Holm AM, Kongerud J, Bentsen SB, Paul SM, Miaskowski C, Rustøen T (2016)
Occurrence, Characteristics, and Predictors of Pain in Patients with Chronic Obstructive Pulmonary Disease
Pain Manag Nurs, 17 (2), 107-18
DOI 10.1016/j.pmn.2016.01.002, PubMed 27095390

Christensen VL, Rustøen T, Cooper BA, Miaskowski C, Henriksen AH, Bentsen SB, Holm AM (2016)
Distinct symptom experiences in subgroups of patients with COPD
Int J Chron Obstruct Pulmon Dis, 11, 1801-9
DOI 10.2147/COPD.S105299, PubMed 27536092

Eguíluz-Gracia I, Schultz HH, Sikkeland LI, Danilova E, Holm AM, Pronk CJ, Agace WW, Iversen M, Andersen C, Jahnsen FL, Baekkevold ES (2016)
Long-term persistence of human donor alveolar macrophages in lung transplant recipients
Thorax, 71 (11), 1006-1011
DOI 10.1136/thoraxjnl-2016-208292, PubMed 27329043

Greer M, Riise GC, Hansson L, Perch M, Hämmäinen P, Roux A, Hirschi S, Lhuillier E, Reynaud-Gaubert M, Philit F, Claustre J, Stern M, Gottlieb J, Holm AM (2016)
Dichotomy in pulmonary graft-versus-host disease evident among allogeneic stem-cell transplant recipients undergoing lung transplantation
Eur Respir J, 48 (6), 1807-1810
DOI 10.1183/13993003.01121-2016, PubMed 27587560

Halvorsen AR, Bjaanæs M, LeBlanc M, Holm AM, Bolstad N, Rubio L, Peñalver JC, Cervera J, Mojarrieta JC, López-Guerrero JA, Brustugun OT, Helland Å (2016)
A unique set of 6 circulating microRNAs for early detection of non-small cell lung cancer
Oncotarget, 7 (24), 37250-37259
DOI 10.18632/oncotarget.9363, PubMed 27191990

Publications 2013

Auråen H, Mollnes TE, Bjørtuft Ø, Bakkan PA, Geiran O, Kongerud J, Fiane A, Holm AM (2013)
Multiorgan procurement increases systemic inflammation in brain dead donors
Clin Transplant, 27 (4), 613-8
DOI 10.1111/ctr.12175, PubMed 23803161

Gregersen S, Holm AM, Fevang B, Ueland T, Sikkeland LI, Aaløkken TM, Mynarek G, Kongerud J, Aukrust P, Johansen B, Frøland SS (2013)
Lung disease, T-cells and inflammation in common variable immunodeficiency disorders
Scand J Clin Lab Invest, 73 (6), 514-22
DOI 10.3109/00365513.2013.819523, PubMed 23957371

Holm AM, Riise GC, Brinch L, Bjørtuft O, Iversen M, Simonsen S, Fløisand Y (2013)
Lung transplantation for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation: unresolved questions
Transplantation, 96 (4), e21-2
DOI 10.1097/TP.0b013e31829df2c0, PubMed 23958883

Publications 2012

Holm AM, Riise GC, Hansson L, Brinch L, Bjørtuft O, Iversen M, Simonsen S, Fløisand Y (2012)
Lung transplantation for bronchiolitis obliterans syndrome after allo-SCT
Bone Marrow Transplant, 48 (5), 703-7
DOI 10.1038/bmt.2012.197, PubMed 23064037

Publications 2010

Gregersen S, Aaløkken TM, Mynarek G, Fevang B, Holm AM, Ueland T, Aukrust P, Kongerud J, Johansen B, Frøland SS (2010)
Development of pulmonary abnormalities in patients with common variable immunodeficiency: associations with clinical and immunologic factors
Ann Allergy Asthma Immunol, 104 (6), 503-10
DOI 10.1016/j.anai.2010.04.015, PubMed 20568383

Publications 2009

Fevang B, Yndestad A, Damås JK, Halvorsen B, Holm AM, Beiske K, Aukrust P, Frøland SS (2009)
Chemokines and common variable immunodeficiency; possible contribution of CCL19, CCL21 and CCR7 to immune dysregulation
Clin Exp Immunol, 158 (2), 237-45
DOI 10.1111/j.1365-2249.2009.04013.x, PubMed 19747210

Publications 2008

Dahl CP, Gullestad L, Fevang B, Holm AM, Landrø L, Vinge LE, Fiane AE, Sandberg WJ, Otterdal K, Frøland SS, Damås JK, Halvorsen B, Aukrust P, Øie E, Yndestad A (2008)
Increased expression of LIGHT/TNFSF14 and its receptors in experimental and clinical heart failure
Eur J Heart Fail, 10 (4), 352-9
DOI 10.1016/j.ejheart.2008.02.010, PubMed 18353719

Fevang B, Yndestad A, Damås JK, Bjerkeli V, Ueland T, Holm AM, Beiske K, Aukrust P, Frøland SS (2008)
Chemokines and common variable immunodeficiency; possible contribution of the fractalkine system (CX3CL1/CX3CR1) to chronic inflammation
Clin Immunol, 130 (2), 151-61
DOI 10.1016/j.clim.2008.09.002, PubMed 18938112

Salzer U, Bacchelli C, Buckridge S, Pan-Hammarström Q, Jennings S, Lougaris V, Bergbreiter A, Hagena T, Birmelin J, Plebani A, Webster AD, Peter HH, Suez D, Chapel H, McLean-Tooke A, Spickett GP, Anover-Sombke S, Ochs HD, Urschel S, Belohradsky BH, Ugrinovic S, Kumararatne DS, Lawrence TC, Holm AM, Franco JL et al. (2008)
Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes
Blood, 113 (9), 1967-76
DOI 10.1182/blood-2008-02-141937, PubMed 18981294

Publications 2007

Fevang B, Yndestad A, Sandberg WJ, Holm AM, Müller F, Aukrust P, Frøland SS (2007)
Low numbers of regulatory T cells in common variable immunodeficiency: association with chronic inflammation in vivo
Clin Exp Immunol, 147 (3), 521-5
DOI 10.1111/j.1365-2249.2006.03314.x, PubMed 17302902

Publications 2006

Holm AM, Tjønnfjord G, Yndestad A, Beiske K, Müller F, Aukrust P, Frøland SS (2006)
Polyclonal expansion of large granular lymphocytes in common variable immunodeficiency - association with neutropenia
Clin Exp Immunol, 144 (3), 418-24
DOI 10.1111/j.1365-2249.2006.03086.x, PubMed 16734610

Publications 2005

Fevang B, Mollnes TE, Holm AM, Ueland T, Heggelund L, Damås JK, Aukrust P, Frøland SS (2005)
Common variable immunodeficiency and the complement system; low mannose-binding lectin levels are associated with bronchiectasis
Clin Exp Immunol, 142 (3), 576-84
DOI 10.1111/j.1365-2249.2005.02951.x, PubMed 16297171

Holm AM (2005)
T cell dysfunction in common variable immunodeficiency
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 385, 1 b. (flere pag.)
BIBSYS 060457058, ISBN 82-8072-838-4

Publications 2004

Heggelund L, Damås JK, Yndestad A, Holm AM, Mūller F, Lien E, Espevik T, Aukrust P, Frøland SS (2004)
Stimulation of toll-like receptor 2 in mononuclear cells from HIV-infected patients induces chemokine responses: possible pathogenic consequences
Clin Exp Immunol, 138 (1), 116-21
DOI 10.1111/j.1365-2249.2004.02595.x, PubMed 15373913

Holm AM, Aukrust P, Damås JK, Müller F, Halvorsen B, Frøland SS (2004)
Abnormal interleukin-7 function in common variable immunodeficiency
Blood, 105 (7), 2887-90
DOI 10.1182/blood-2004-06-2423, PubMed 15598813

Holm AM, Sivertsen EA, Tunheim SH, Haug T, Bjerkeli V, Yndestad A, Aukrust P, Frøland SS (2004)
Gene expression analysis of peripheral T cells in a subgroup of common variable immunodeficiency shows predominance of CCR7(-) effector-memory T cells
Clin Exp Immunol, 138 (2), 278-89
DOI 10.1111/j.1365-2249.2004.02630.x, PubMed 15498038

Salzer U, Maul-Pavicic A, Cunningham-Rundles C, Urschel S, Belohradsky BH, Litzman J, Holm A, Franco JL, Plebani A, Hammarstrom L, Skrabl A, Schwinger W, Grimbacher B (2004)
ICOS deficiency in patients with common variable immunodeficiency
Clin Immunol, 113 (3), 234-40
DOI 10.1016/j.clim.2004.07.002, PubMed 15507387

Publications 2003

Holm AM, Aukrust P, Aandahl EM, Müller F, Taskén K, Frøland SS (2003)
Impaired secretion of IL-10 by T cells from patients with common variable immunodeficiency--involvement of protein kinase A type I
J Immunol, 170 (11), 5772-7
DOI 10.4049/jimmunol.170.11.5772, PubMed 12759461

Waehre T, Damås JK, Gullestad L, Holm AM, Pedersen TR, Arnesen KE, Torsvik H, Frøland SS, Semb AG, Aukrust P (2003)
Hydroxymethylglutaryl coenzyme a reductase inhibitors down-regulate chemokines and chemokine receptors in patients with coronary artery disease
J Am Coll Cardiol, 41 (9), 1460-7
DOI 10.1016/s0735-1097(03)00263-8, PubMed 12742282

Wæhre T, Damas JK, Gullestad L, Holm AM, Pedersen TR, Arnesen KE, Torsvik H, Froland SS, Semb AGP, Aukrust P (2003)
Hydroxymethylglutaryl coenzyme a reductase inhibitors down-regulate chemokines and chemokine receptors in patients with coronary artery disease
In Journal of the American College of Cardiology, Elsevier, New York, 41(2003)9, s.1460-7
BIBSYS 041728793

Yndestad A, Holm AM, Müller F, Simonsen S, Frøland SS, Gullestad L, Aukrust P (2003)
Enhanced expression of inflammatory cytokines and activation markers in T-cells from patients with chronic heart failure
Cardiovasc Res, 60 (1), 141-6
DOI 10.1016/s0008-6363(03)00362-6, PubMed 14522416

Publications 2002

Damås JK, Waehre T, Yndestad A, Ueland T, Müller F, Eiken HG, Holm AM, Halvorsen B, Frøland SS, Gullestad L, Aukrust P (2002)
Stromal cell-derived factor-1alpha in unstable angina: potential antiinflammatory and matrix-stabilizing effects
Circulation, 106 (1), 36-42
DOI 10.1161/01.cir.0000020001.09990.90, PubMed 12093767

Holm AM, Berild D, Ringertz SH, Haheim LL, Høiby EA (2002)
Occurence and clinical presentation of systemic pneumococcal infections in an unselected population in Oslo, Norway, between 1993 and 1997
In European journal of clinical microbiology & infectious diseases, Vieweg, Wiesbaden, 21(2002)nr 6, s. 465-467
BIBSYS 031275397

Holm AM, Berild D, Ringertz SH, Håheim LL, Høiby EA (2002)
Occurrence and clinical presentation of systemic pneumococcal infections in an unselected population in Oslo, Norway, between 1993 and 1997
Eur J Clin Microbiol Infect Dis, 21 (6), 465-7
DOI 10.1007/s10096-002-0751-z, PubMed 12111604

Publications 1997

Holm AM, Berild D (1997)
[Pneumococcal endocarditis of the tricuspid valve. A case report with review of the literature]
Tidsskr Nor Laegeforen, 117 (6), 815-7
PubMed 9102976