Fibroids and Infertility FIN
Summary
Uterine fibroids (leiomyomas) are among the most common benign tumors in reproductive-aged women, affecting up to 40% of individuals. While many fibroids are asymptomatic, some can contribute to infertility by altering the uterine environment. Research suggests that fibroids may impair endometrial receptivity—the ability of the uterine lining to support embryo implantation—by disrupting molecular and vascular processes essential for successful pregnancy. However, the exact mechanisms remain unclear, and the benefit of fibroid removal (myomectomy) in improving fertility outcomes is still debated.
This study seeks to clarify the role of fibroids in infertility by examining gene expression patterns in the endometrium of women with fibroids before and after myomectomy. By analyzing molecular markers associated with implantation, we aim to determine whether fibroid removal restores endometrial function. Additionally, the study will assess how fibroid characteristics—including size, number, location, and vascularity—affect fertility outcomes. Findings from this research will help refine treatment strategies for women with fibroid-related infertility, guiding clinical decisions on when myomectomy is beneficial.
Objectives & Study Design
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Endometrial Receptivity & Gene Expression – Investigating key implantation markers, such as HOXA10, to determine how fibroids impact molecular signals necessary for embryo implantation.
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Impact of Fibroid Characteristics – Evaluating how factors like fibroid size, location, and vascularity influence fertility, providing insight into which patients may benefit from surgical intervention.
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Comparative Study – Comparing molecular and vascular changes in women with fibroids to those in fertile and infertile control groups to assess differences in endometrial function.
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By identifying the biological mechanisms underlying fibroid-related infertility, this study aims to improve patient selection for myomectomy and optimize fertility treatment strategies.