Publications 2024

Rezai Jahromi B, Valori M, Tulamo R, Jauhiainen S, Ilmonen H, Kantonen J, Kaikkonen-Määttä M, Laakso A, Ylä-Hertuala S, Jääskeläinen JE, Tienari PJ, Niemelä M (2024)
Cancer-type somatic mutations in saccular cerebral aneurysms
Eur J Hum Genet (in press)
DOI 10.1038/s41431-024-01765-x, PubMed 39668185

Publications 2023

Järvinen E, Suomi F, Stewart JB, Guala D, Valori M, Jansson L, Nieminen J, McWilliams TG, Tienari PJ (2023)
Cultured lymphocytes' mitochondrial genome integrity is not altered by cladribine
Clin Exp Immunol, 214 (3), 304-313
DOI 10.1093/cei/uxad112, PubMed 37860849

Lehikoinen J, Valori M, Jääskeläinen AJ, Laakso SM, Arstila TP, Tienari PJ (2023)
High Epstein-Barr virus capsid antigen IgG level associates with the carriership of CD8+ T cell somatic mutations in the STAT3 SH2 domain
Clin Immunol, 255, 109733
DOI 10.1016/j.clim.2023.109733, PubMed 37572949

Publications 2022

Valori M, Lehikoinen J, Jansson L, Clancy J, Lundgren SA, Mustjoki S, Tienari P (2022)
High prevalence of low-allele-fraction somatic mutations in STAT3 in peripheral blood CD8+ cells in multiple sclerosis patients and controls
PLoS One, 17 (11), e0278245
DOI 10.1371/journal.pone.0278245, PubMed 36441748

Publications 2021

Hathaway J, Heliö K, Saarinen I, Tallila J, Seppälä EH, Tuupanen S, Turpeinen H, Kangas-Kontio T, Schleit J, Tommiska J, Kytölä V, Valori M, Muona M, Sistonen J, Gentile M, Salmenperä P, Myllykangas S, Paananen J, Alastalo TP, Heliö T, Koskenvuo J (2021)
Diagnostic yield of genetic testing in a heterogeneous cohort of 1376 HCM patients
BMC Cardiovasc Disord, 21 (1), 126
DOI 10.1186/s12872-021-01927-5, PubMed 33673806

Johnson JO, Chia R, Miller DE, Li R, Kumaran R, Abramzon Y, Alahmady N, Renton AE, Topp SD, Gibbs JR, Cookson MR, Sabir MS, Dalgard CL, Troakes C, Jones AR, Shatunov A, Iacoangeli A, Al Khleifat A, Ticozzi N, Silani V, Gellera C, Blair IP, Dobson-Stone C, Kwok JB, Bonkowski ES et al. (2021)
Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis
JAMA Neurol, 78 (10), 1236-1248
DOI 10.1001/jamaneurol.2021.2598, PubMed 34459874

Valori M, Jansson L, Tienari PJ (2021)
CD8+ cell somatic mutations in multiple sclerosis patients and controls-Enrichment of mutations in STAT3 and other genes implicated in hematological malignancies
PLoS One, 16 (12), e0261002
DOI 10.1371/journal.pone.0261002, PubMed 34874980

Publications 2019

Kuuluvainen L, Kaivola K, Mönkäre S, Laaksovirta H, Jokela M, Udd B, Valori M, Pasanen P, Paetau A, Traynor BJ, Stone DJ, Schleutker J, Pöyhönen M, Tienari PJ, Myllykangas L (2019)
Oligogenic basis of sporadic ALS: The example of SOD1 p.Ala90Val mutation
Neurol Genet, 5 (3), e335
DOI 10.1212/NXG.0000000000000335, PubMed 31086828

Publications 2018

McWilliams TG, Barini E, Pohjolan-Pirhonen R, Brooks SP, Singh F, Burel S, Balk K, Kumar A, Montava-Garriga L, Prescott AR, Hassoun SM, Mouton-Liger F, Ball G, Hills R, Knebel A, Ulusoy A, Di Monte DA, Tamjar J, Antico O, Fears K, Smith L, Brambilla R, Palin E, Valori M, Eerola-Rautio J et al. (2018)
Phosphorylation of Parkin at serine 65 is essential for its activation in vivo
Open Biol, 8 (11)
DOI 10.1098/rsob.180108, PubMed 30404819

Mäkelä M, Kaivola K, Valori M, Paetau A, Polvikoski T, Singleton AB, Traynor BJ, Stone DJ, Peuralinna T, Tienari PJ, Tanskanen M, Myllykangas L (2018)
Alzheimer risk loci and associated neuropathology in a population-based study (Vantaa 85+)
Neurol Genet, 4 (1), e211
DOI 10.1212/NXG.0000000000000211, PubMed 29379882

Nicolas A, Kenna KP, Renton AE, Ticozzi N, Faghri F, Chia R, Dominov JA, Kenna BJ, Nalls MA, Keagle P, Rivera AM, van Rheenen W, Murphy NA, van Vugt JJFA, Geiger JT, Van der Spek RA, Pliner HA, Shankaracharya, Smith BN, Marangi G, Topp SD, Abramzon Y, Gkazi AS, Eicher JD, Kenna A et al. (2018)
Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
Neuron, 97 (6), 1267-1288
DOI 10.1016/j.neuron.2018.02.027, PubMed 29566793

Publications 2017

Mustonen T, Schmidt EK, Valori M, Tienari PJ, Atula S, Kiuru-Enari S (2017)
Common origin of the gelsolin gene variant in 62 Finnish AGel amyloidosis families
Eur J Hum Genet, 26 (1), 117-123
DOI 10.1038/s41431-017-0026-x, PubMed 29167514

Publications 2016

Tienari P, Kiviharju A, Valori M, Lindholm D, Laaksovirta H (2016)
[The pathogenesis of amyotrophic lateral sclerosis and frontal lobe dementia is unraveling: pathology of the nucleus and glutamate sensitivity]
Duodecim, 132 (5), 423-31
PubMed 27089615

Valori M, Jansson L, Kiviharju A, Ellonen P, Rajala H, Awad SA, Mustjoki S, Tienari PJ (2016)
A novel class of somatic mutations in blood detected preferentially in CD8+ cells
Clin Immunol, 175, 75-81
DOI 10.1016/j.clim.2016.11.018, PubMed 27932211

Publications 2015

Peuralinna T, Myllykangas L, Oinas M, Nalls MA, Keage HA, Isoviita VM, Valori M, Polvikoski T, Paetau A, Sulkava R, Ince PG, Zaccai J, Brayne C, Traynor BJ, Hardy J, Singleton AB, Tienari PJ (2015)
Genome-wide association study of neocortical Lewy-related pathology
Ann Clin Transl Neurol, 2 (9), 920-31
DOI 10.1002/acn3.231, PubMed 26401513

Siuko M, Valori M, Kivelä T, Setälä K, Morin A, Kwan T, Pastinen T, Tienari P (2015)
Exome and regulatory element sequencing of neuromyelitis optica patients
J Neuroimmunol, 289, 139-42
DOI 10.1016/j.jneuroim.2015.11.002, PubMed 26616883

Publications 2014

Rantanen V, Valori M, Hautaniemi S (2014)
Anima: modular workflow system for comprehensive image data analysis
Front Bioeng Biotechnol, 2, 25
DOI 10.3389/fbioe.2014.00025, PubMed 25126541

Savilahti EM, Kuitunen M, Valori M, Rantanen V, Bardina L, Gimenez G, Mäkelä MJ, Hautaniemi S, Savilahti E, Sampson HA (2014)
Use of IgE and IgG4 epitope binding to predict the outcome of oral immunotherapy in cow's milk allergy
Pediatr Allergy Immunol, 25 (3), 227-35
DOI 10.1111/pai.12186, PubMed 24393339

Solje E, Hartikainen P, Valori M, Vanninen R, Tiihonen J, Hakola P, Tienari PJ, Remes AM (2014)
C9ORF72 expansion does not affect the phenotype in Nasu-Hakola disease with the DAP12 mutation
Neurobiol Aging, 35 (7), 1780.e13-7
DOI 10.1016/j.neurobiolaging.2014.01.149, PubMed 24612676