Manuela MX Tan

  • Postdoctoral fellow; PhD
 

Publications 2021

Alfradique-Dunham I, Al-Ouran R, von Coelln R, Blauwendraat C, Hill E, Luo L, Stillwell A, Young E, Kaw A, Tan M, Liao C, Hernandez D, Pihlstrom L, Grosset D, Shulman LM, Liu Z, Rouleau GA, Nalls M, Singleton AB, Morris H, Jankovic J, Shulman JM (2021)
Genome-Wide Association Study Meta-Analysis for Parkinson Disease Motor Subtypes
Neurol Genet, 7 (2), e557
DOI 10.1212/NXG.0000000000000557, PubMed 33987465

Blauwendraat C, Iwaki H, Makarious MB, Bandres-Ciga S, Leonard H, Grenn FP, Lake J, Krohn L, Tan M, Kim JJ, Gibbs JR, Hernandez DG, Ruskey JA, Pihlstrøm L, Toft M, van Hilten JJ, Marinus J, Schulte C, Brockmann K, Sharma M, Siitonen A, Majamaa K, Eerola-Rautio J, Tienari PJ, Grosset DG et al. (2021)
Investigation of Autosomal Genetic Sex Differences in Parkinson's disease
Ann Neurol (in press)
DOI 10.1002/ana.26090, PubMed 33901317

Lubbe SJ, Bustos BI, Hu J, Krainc D, Joseph T, Hehir J, Tan M, Zhang W, Escott-Price V, Williams NM, Blauwendraat C, Singleton AB, Morris HR, for International Parkinson’s Disease Genomics Consortium (IPDGC) (2021)
Assessing the relationship between monoallelic PRKN mutations and Parkinson's risk
Hum Mol Genet, 30 (1), 78-86
DOI 10.1093/hmg/ddaa273, PubMed 33448283

Oxtoby NP, Leyland LA, Aksman LM, Thomas GEC, Bunting EL, Wijeratne PA, Young AL, Zarkali A, Tan MMX, Bremner FD, Keane PA, Morris HR, Schrag AE, Alexander DC, Weil RS (2021)
Sequence of clinical and neurodegeneration events in Parkinson's disease progression
Brain, 144 (3), 975-988
DOI 10.1093/brain/awaa461, PubMed 33543247

Publications 2020

Blauwendraat C, Reed X, Krohn L, Heilbron K, Bandres-Ciga S, Tan M, Gibbs JR, Hernandez DG, Kumaran R, Langston R, Bonet-Ponce L, Alcalay RN, Hassin-Baer S, Greenbaum L, Iwaki H, Leonard HL, Grenn FP, Ruskey JA, Sabir M, Ahmed S, Makarious MB, Pihlstrøm L, Toft M, van Hilten JJ, Marinus J et al. (2020)
Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia
Brain, 143 (1), 234-248
DOI 10.1093/brain/awz350, PubMed 31755958

Brown EE, Blauwendraat C, Trinh J, Rizig M, Nalls MA, Leveille E, Ruskey JA, Jonvik H, Tan MMX, Bandres-Ciga S, Hassin-Baer S, Brockmann K, Infante J, Tolosa E, Ezquerra M, Ben Romdhan S, Benmahdjoub M, Arezki M, Mhiri C, Hardy J, Singleton AB, Alcalay RN, Gasser T, Grosset DG, Williams NM et al. (2020)
Analysis of DNM3 and VAMP4 as genetic modifiers of LRRK2 Parkinson's disease
Neurobiol Aging, 97, 148.e17-148.e24
DOI 10.1016/j.neurobiolaging.2020.07.002, PubMed 32873436

Jabbari E, Holland N, Chelban V, Jones PS, Lamb R, Rawlinson C, Guo T, Costantini AA, Tan MMX, Heslegrave AJ, Roncaroli F, Klein JC, Ansorge O, Allinson KSJ, Jaunmuktane Z, Holton JL, Revesz T, Warner TT, Lees AJ, Zetterberg H, Russell LL, Bocchetta M, Rohrer JD, Williams NM, Grosset DG et al. (2020)
Diagnosis Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Syndrome
JAMA Neurol, 77 (3), 377-387
DOI 10.1001/jamaneurol.2019.4347, PubMed 31860007

Jabbari E, Koga S, Valentino RR, Reynolds RH, Ferrari R, Tan MMX, Rowe JB, Dalgard CL, Scholz SW, Dickson DW, Warner TT, Revesz T, Höglinger GU, Ross OA, Ryten M, Hardy J, Shoai M, Morris HR, PSP Genetics Group (2020)
Genetic determinants of survival in progressive supranuclear palsy: a genome-wide association study
Lancet Neurol, 20 (2), 107-116
DOI 10.1016/S1474-4422(20)30394-X, PubMed 33341150

Tan MMX, Lawton MA, Jabbari E, Reynolds RH, Iwaki H, Blauwendraat C, Kanavou S, Pollard MI, Hubbard L, Malek N, Grosset KA, Marrinan SL, Bajaj N, Barker RA, Burn DJ, Bresner C, Foltynie T, Wood NW, Williams-Gray CH, Hardy J, Nalls MA, Singleton AB, Williams NM, Ben-Shlomo Y, Hu MTM et al. (2020)
Genome-Wide Association Studies of Cognitive and Motor Progression in Parkinson's Disease
Mov Disord, 36 (2), 424-433
DOI 10.1002/mds.28342, PubMed 33111402

Publications 2019

Bandres-Ciga S, Ahmed S, Sabir MS, Blauwendraat C, Adarmes-Gómez AD, Bernal-Bernal I, Bonilla-Toribio M, Buiza-Rueda D, Carrillo F, Carrión-Claro M, Gómez-Garre P, Jesús S, Labrador-Espinosa MA, Macias D, Méndez-Del-Barrio C, Periñán-Tocino T, Tejera-Parrado C, Vargas-González L, Diez-Fairen M, Alvarez I, Tartari JP, Buongiorno M, Aguilar M, Gorostidi A, Bergareche JA et al. (2019)
The Genetic Architecture of Parkinson Disease in Spain: Characterizing Population-Specific Risk, Differential Haplotype Structures, and Providing Etiologic Insight
Mov Disord, 34 (12), 1851-1863
DOI 10.1002/mds.27864, PubMed 31660654

Blauwendraat C, Heilbron K, Vallerga CL, Bandres-Ciga S, von Coelln R, Pihlstrøm L, Simón-Sánchez J, Schulte C, Sharma M, Krohn L, Siitonen A, Iwaki H, Leonard H, Noyce AJ, Tan M, Gibbs JR, Hernandez DG, Scholz SW, Jankovic J, Shulman LM, Lesage S, Corvol JC, Brice A, van Hilten JJ, Marinus J et al. (2019)
Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms
Mov Disord, 34 (6), 866-875
DOI 10.1002/mds.27659, PubMed 30957308

Fernandez-Santiago R, Martin-Flores N, Antonelli F, Cerquera C, Moreno V, Bandres-Ciga S, Manduchi E, Tolosa E, Singleton AB, Moore JH, Noyce AJ, Kaiyrzhanov R, Middlehurst B, Kia DA, Tan M, Houlden H, Morris HR, Plun-Favreau H, Holmans P, Hardy J, Trabzuni D, Bras J, Quinn J, Mok KY, Kinghorn KJ et al. (2019)
SNCA and mTOR Pathway Single Nucleotide Polymorphisms Interact to Modulate the Age at Onset of Parkinson's Disease
Mov. Disord., 34 (9), 1333-1344

Jabbari E, Woodside J, Tan MMX, Pavese N, Bandmann O, Ghosh BCP, Massey LA, Capps E, Warner TT, Lees AJ, Revesz T, Holton JL, Williams NM, Grosset DG, Morris HR (2019)
The genetic and clinico-pathological profile of early-onset progressive supranuclear palsy
Mov Disord, 34 (9), 1307-1314
DOI 10.1002/mds.27786, PubMed 31299107

Nalls MA, Blauwendraat C, Vallerga CL, Heilbron K, Bandres-Ciga S, Chang D, Tan M, Kia DA, Noyce AJ, Xue A, Bras J, Young E, von Coelln R, Simón-Sánchez J, Schulte C, Sharma M, Krohn L, Pihlstrøm L, Siitonen A, Iwaki H, Leonard H, Faghri F, Gibbs JR, Hernandez DG, Scholz SW et al. (2019)
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
Lancet Neurol, 18 (12), 1091-1102
DOI 10.1016/S1474-4422(19)30320-5, PubMed 31701892

Tan MMX, Malek N, Lawton MA, Hubbard L, Pittman AM, Joseph T, Hehir J, Swallow DMA, Grosset KA, Marrinan SL, Bajaj N, Barker RA, Burn DJ, Bresner C, Foltynie T, Hardy J, Wood N, Ben-Shlomo Y, Grosset DG, Williams NM, Morris HR (2019)
Genetic analysis of Mendelian mutations in a large UK population-based Parkinson's disease study
Brain, 142 (9), 2828-2844
DOI 10.1093/brain/awz191, PubMed 31324919

Publications 2018

Jabbari E, Woodside J, Tan MMX, Shoai M, Pittman A, Ferrari R, Mok KY, Zhang D, Reynolds RH, de Silva R, Grimm MJ, Respondek G, Müller U, Al-Sarraj S, Gentleman SM, Lees AJ, Warner TT, Hardy J, Revesz T, Höglinger GU, Holton JL, Ryten M, Morris HR (2018)
Variation at the TRIM11 locus modifies progressive supranuclear palsy phenotype
Ann Neurol, 84 (4), 485-496
DOI 10.1002/ana.25308, PubMed 30066433

Malek N, Weil RS, Bresner C, Lawton MA, Grosset KA, Tan M, Bajaj N, Barker RA, Burn DJ, Foltynie T, Hardy J, Wood NW, Ben-Shlomo Y, Williams NW, Grosset DG, Morris HR, PRoBaND clinical consortium (2018)
Features of GBA-associated Parkinson's disease at presentation in the UK Tracking Parkinson's study
J Neurol Neurosurg Psychiatry, 89 (7), 702-709
DOI 10.1136/jnnp-2017-317348, PubMed 29378790

Publications 2017

Johnston IN, Tan M, Cao J, Matsos A, Forrest DRL, Si E, Fardell JE, Hutchinson MR (2017)
Ibudilast reduces oxaliplatin-induced tactile allodynia and cognitive impairments in rats
Behav Brain Res, 334, 109-118
DOI 10.1016/j.bbr.2017.07.021, PubMed 28739131

Norman BP, Lubbe SJ, Tan M, Warren N, Morris HR (2017)
Early Onset Parkinson's Disease in a family of Moroccan origin caused by a p.A217D mutation in PINK1: a case report
BMC Neurol, 17 (1), 153
DOI 10.1186/s12883-017-0933-z, PubMed 28789629

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