Research projects

Clinical studies:

  • TAME (multicenter international RCT on permissive hypercapnia vs normocapnia during post-resuscitation care in out-of-hospital cardiac arrest (OHCA) patients
  • ORANGE (multicenter international RCT investigating Pupillometry for prognostication in comatose patients after severe intracranial bleeding)
  • REBOARREST trial (multicenter national RCT investigating effects of ballon-occlusion of the thoracic part of aorta to improve vital organ perfusion and survival during OHCA) 
  • Substudies from TAME: different haemodynamic and myocardial effects related to hypercapnia in cardiac arrest patients during post-resuscitation care using Swan-Ganz catheters and echocardiography
  • Substudies from NORCAST (clinical observation study on prognostication and long term outcome among comatose, primary resuscitated OHCA patients)
    - quality of life in survivors five years after OHCA
    - changes in quality of life between six months and five years in survivors after OHCA
    - long-term (five years) cognitive function after OHCA
    - outcome and prognostic predictors in comatose OHCA patients with initial shockable vs non-shockable rhythms
    - transcranial doppler for prognostication in comatose patients after OHCA
    - blood pressure and associations with outcome during post-resuscitation care after OHCA
    - imaging (CT/MRI) for prognostication in comatose patients after OHCA
    - biobank-studies (complement factors, biomarkers) in comatose resuscitated OHCA patients
  • Comparison of outcome after changing temperature management for comatose admitted resuscitated OHCA patients from therapeutic hypothermia to normothermia
  • Different studies on the effects of early rehabilitation after severe traumatic brain injury 

Experimental pig studies:

  • Cerebral perfusion and metabolism with mean arterial pressure of 60 vs 90 mmHg with and without therapeutic hypothermia in an experimental pig model
  • Haemodynamic effects of different ventilation strategies during resuscitation in an experimental pig model
  • Cerebral perfusion and metabolism with targeted hypercapnia vs normocapnia with and without therapeutic hypothermia in an experimental pig model
 
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