Cecilie Johannessen Landmark
- Professor, Senior researcher; PhD, MScPharm
Affiliations: Complex Epilepsy (Div. of Clin. Neuroscience); Therapeutic Drug Monitoring (Dept. of Pharmacology); OsloMet
Publications 2024
Interactions between antiseizure medications and foods and drinks: A systematic review
Epilepsia Open, 9 (2), 475-485
DOI 10.1002/epi4.12918, PubMed 38345419
Fenfluramine treatment in pediatric patients with Dravet syndrome reduces seizure burden and overall healthcare costs: A retrospective and observational real-world study
Epilepsia Open, 9 (5), 1891-1900
DOI 10.1002/epi4.13029, PubMed 39140199
Pharmacokinetic Variability of Rufinamide and Stiripentol in Children With Refractory Epilepsy: A Retrospective Study of Therapeutic Drug Monitoring From the National Epilepsy Centers in Denmark and Norway
Ther Drug Monit, 46 (5), 664-671
DOI 10.1097/FTD.0000000000001219, PubMed 38758628
Pharmacokinetic variability of everolimus and impact of concomitant antiseizure medications in patients with tuberous sclerosis complex: A retrospective study of therapeutic drug monitoring data in Denmark and Norway
Medicine (Baltimore), 103 (32), e39244
DOI 10.1097/MD.0000000000039244, PubMed 39121325
Access to a tailored mobile application enhances medication adherence among young users of antidepressants
Front Pharmacol, 15, 1379700
DOI 10.3389/fphar.2024.1379700, PubMed 38659579
Publications 2023
Effectiveness and safety of everolimus treatment in patients with tuberous sclerosis complex in real-world clinical practice
Orphanet J Rare Dis, 18 (1), 377
DOI 10.1186/s13023-023-02982-1, PubMed 38042867
Pharmacokinetic Variability of Sulthiame: The Impact of Age, Drug-Drug Interactions, and Biochemical Markers of Toxicity in Patients with Epilepsy
Ther Drug Monit, 46 (2), 237-245
DOI 10.1097/FTD.0000000000001146, PubMed 38158595
Pharmacological aspects of antiseizure medications: From basic mechanisms to clinical considerations of drug interactions and use of therapeutic drug monitoring
Epileptic Disord, 25 (4), 454-471
DOI 10.1002/epd2.20069, PubMed 37259844
Therapeutic Salivary Monitoring of Perampanel in Patients with Epilepsy Using a Volumetric Absorptive Microsampling Technique
Pharmaceutics, 15 (8)
DOI 10.3390/pharmaceutics15082030, PubMed 37631244
Decreased serum concentrations of antiseizure medications in children with drug resistant epilepsy following treatment with ketogenic diet
Epilepsia Open, 8 (3), 858-866
DOI 10.1002/epi4.12746, PubMed 37057954
Publications 2022
Changes in the use of antiseizure medications in children and adolescents in Norway, 2009-2018
Epilepsy Res, 181, 106872
DOI 10.1016/j.eplepsyres.2022.106872, PubMed 35180640
Use of screening tools to assess comorbidities and adverse events in patients with epilepsy. A European Reference Network for Rare and Complex Epilepsies (EpiCARE) survey
Seizure, 101, 237-243
DOI 10.1016/j.seizure.2022.09.008, PubMed 36115293
Development and validation of a new non-disease-specific survey tool to assess self-reported adherence to medication
Front Pharmacol, 13, 981368
DOI 10.3389/fphar.2022.981368, PubMed 36569319
Association Between Antiseizure Drug Monotherapy and Mortality for Patients With Poststroke Epilepsy
JAMA Neurol, 79 (2), 169-175
DOI 10.1001/jamaneurol.2021.4584, PubMed 34902006
Bidirectionality of antiseizure and antipsychotic treatment: A population-based study
Epilepsy Behav, 136, 108911
DOI 10.1016/j.yebeh.2022.108911, PubMed 36126553
Efficacy, tolerability and pharmacokinetic variability of brivaracetam in adults with difficult-to-treat epilepsy
Epilepsy Res, 183, 106946
DOI 10.1016/j.eplepsyres.2022.106946, PubMed 35609355
Publications 2021
A survey of the European Reference Network EpiCARE on clinical practice for selected rare epilepsies
Epilepsia Open, 6 (1), 160-170
DOI 10.1002/epi4.12459, PubMed 33681659
The role of new medical treatments for the management of developmental and epileptic encephalopathies: Novel concepts and results
Epilepsia, 62 (4), 857-873
DOI 10.1111/epi.16849, PubMed 33638459
Pharmacokinetic data on brivaracetam, lacosamide and perampanel during pregnancy and lactation
Epileptic Disord, 23 (2), 426-431
DOI 10.1684/epd.2021.1273, PubMed 33935028
Lamotrigine effects on immune gene expression in larval zebrafish
Epilepsy Res, 178, 106823
DOI 10.1016/j.eplepsyres.2021.106823, PubMed 34844088
Publications 2020
Epilepsy and cannabidiol: a guide to treatment
Epileptic Disord, 22 (1), 1-14
DOI 10.1684/epd.2020.1141, PubMed 32096470
Relationship between saliva and plasma rufinamide concentrations in patients with epilepsy
Epilepsia, 61 (7), e79-e84
DOI 10.1111/epi.16584, PubMed 32562438
A retrospective review of changes and challenges in the use of antiseizure medicines in Dravet syndrome in Norway
Epilepsia Open, 5 (3), 432-441
DOI 10.1002/epi4.12413, PubMed 32913951
Pharmacokinetic Variability During Long-Term Therapeutic Drug Monitoring of Valproate, Clobazam, and Levetiracetam in Patients With Dravet Syndrome
Ther Drug Monit, 42 (5), 744-753
DOI 10.1097/FTD.0000000000000781, PubMed 32558674
Therapeutic drug monitoring of antiepileptic drugs: current status and future prospects
Expert Opin Drug Metab Toxicol, 16 (3), 227-238
DOI 10.1080/17425255.2020.1724956, PubMed 32054370
Pharmacology and drug interactions of cannabinoids
Epileptic Disord, 22 (S1), 16-22
DOI 10.1684/epd.2019.1123, PubMed 31941642
Clinical experience combined with therapeutic drug monitoring of lacosamide
Acta Neurol Scand, 141 (4), 279-286
DOI 10.1111/ane.13206, PubMed 31853958
Publications 2019
[Continued importance of valproate for women with generalised epilepsy]
Tidsskr Nor Laegeforen, 139 (7)
DOI 10.4045/tidsskr.19.0220, PubMed 30969058
Safety aspects of antiepileptic drugs-a population-based study of adverse effects relative to changes in utilisation
Eur J Clin Pharmacol, 75 (8), 1153-1160
DOI 10.1007/s00228-019-02678-1, PubMed 31001654
Interdisciplinary medication review to improve pharmacotherapy for patients with intellectual disabilities
Int J Clin Pharm, 41 (6), 1516-1525
DOI 10.1007/s11096-019-00914-3, PubMed 31729635
Nonadherence to treatment regimens in epilepsy from the patient's perspective and predisposing factors: Differences between intentional and unintentional lack of adherence
Epilepsia, 60 (5), e58-e62
DOI 10.1111/epi.14734, PubMed 30980675
Sexual function in people with epilepsy: Similarities and differences with the general population
Epilepsia, 60 (9), 1984-1992
DOI 10.1111/epi.16311, PubMed 31407332
Challenges in epilepsy-The perspective of Norwegian epilepsy patients
Acta Neurol Scand, 140 (1), 40-47
DOI 10.1111/ane.13098, PubMed 30963535
Refractory epilepsy and nonadherence to drug treatment
Epilepsia Open, 4 (4), 618-623
DOI 10.1002/epi4.12367, PubMed 31819918
Long-term follow-up with therapeutic drug monitoring of antiepileptic drugs in patients with juvenile myoclonic epilepsy
Epilepsy Res, 155, 106148
DOI 10.1016/j.eplepsyres.2019.05.016, PubMed 31195184
Treatment and challenges with antiepileptic drugs in patients with juvenile myoclonic epilepsy
Epilepsy Behav, 98 (Pt A), 110-116
DOI 10.1016/j.yebeh.2019.05.021, PubMed 31330379
Therapeutic drug monitoring of gabapentin in various indications
Acta Neurol Scand, 139 (5), 446-454
DOI 10.1111/ane.13075, PubMed 30710348
Pharmacokinetic Variability and Clinical Use of Lacosamide in Children and Adolescents in Denmark and Norway
Ther Drug Monit, 41 (3), 340-347
DOI 10.1097/FTD.0000000000000599, PubMed 30688870
Publications 2018
Pharmacokinetic variability of valproate during pregnancy - Implications for the use of therapeutic drug monitoring
Epilepsy Res, 141, 31-37
DOI 10.1016/j.eplepsyres.2018.02.004, PubMed 29453075
Reference ranges for antiepileptic drugs revisited: a practical approach to establish national guidelines
Drug Des Devel Ther, 12, 271-280
DOI 10.2147/DDDT.S154388, PubMed 29467570
Antiepileptic drug withdrawal in juvenile myoclonic epilepsy
Acta Neurol Scand, 139 (2), 192-198
DOI 10.1111/ane.13042, PubMed 30378684
Publications 2017
Utilisation and polypharmacy aspects of antiepileptic drugs in elderly versus younger patients with epilepsy: A pharmacoepidemiological study of CNS-active drugs in Norway, 2004-2015
Epilepsy Res, 139, 35-42
DOI 10.1016/j.eplepsyres.2017.11.001, PubMed 29175562
Erratum to: Changes in utilisation of antiepileptic drugs in epilepsy and non-epilepsy disorders-A pharmacoepidemiological study and clinical implications
Eur J Clin Pharmacol, 73 (6), 791-792
DOI 10.1007/s00228-017-2252-0, PubMed 28389679
Pharmacokinetic variability of valproate in women of childbearing age
Epilepsia, 58 (10), e142-e146
DOI 10.1111/epi.13872, PubMed 28833045
Specific Patient Features Affect Antiepileptic Drug Therapy Decisions: Focus on Gender, Age, and Psychiatric Comorbidities
Curr Pharm Des, 23 (37), 5639-5648
DOI 10.2174/1381612823666170926103631, PubMed 28950817
Harmonised reference ranges for antiepileptic drugs
Tidsskr Nor Laegeforen, 137 (12-13), 864-865
DOI 10.4045/tidsskr.17.0392, PubMed 28655236
Common reference range for antiepileptics
Tidsskr. Nor. Laegeforen., 137 (12-13), 864-865
Therapeutic Drug Monitoring of Lacosamide in Norway: Focus on Pharmacokinetic Variability, Efficacy and Tolerability
Neurochem Res, 42 (7), 2077-2083
DOI 10.1007/s11064-017-2234-8, PubMed 28349359
Publications 2016
Changes in utilisation of antiepileptic drugs in epilepsy and non-epilepsy disorders-a pharmacoepidemiological study and clinical implications
Eur J Clin Pharmacol, 72 (10), 1245-1254
DOI 10.1007/s00228-016-2092-3, PubMed 27411937
Therapeutic Drug Monitoring of Clobazam and Its Metabolite-Impact of Age and Comedication on Pharmacokinetic Variability
Ther Drug Monit, 38 (3), 350-7
DOI 10.1097/FTD.0000000000000272, PubMed 26751267
Prevalence of Different Combinations of Antiepileptic Drugs and CNS Drugs in Elderly Home Care Service and Nursing Home Patients in Norway
Epilepsy Res Treat, 2016, 5153093
DOI 10.1155/2016/5153093, PubMed 27525114
Proconvulsant effects of antidepressants - What is the current evidence?
Epilepsy Behav, 61, 287-291
DOI 10.1016/j.yebeh.2016.01.029, PubMed 26926001
The Impact of Pharmacokinetic Interactions With Eslicarbazepine Acetate Versus Oxcarbazepine and Carbamazepine in Clinical Practice
Ther Drug Monit, 38 (4), 499-505
DOI 10.1097/FTD.0000000000000306, PubMed 27414974
Dosing strategies for antiepileptic drugs: from a standard dose for all to individualised treatment by implementation of therapeutic drug monitoring
Epileptic Disord, 18 (4), 367-383
DOI 10.1684/epd.2016.0880, PubMed 27965183
Discrepancies between physicians' prescriptions and patients' use of antiepileptic drugs
Acta Neurol Scand, 135 (1), 80-87
DOI 10.1111/ane.12578, PubMed 26923477
Pharmacokinetic variability, efficacy and tolerability of eslicarbazepine acetate-A national approach to the evaluation of therapeutic drug monitoring data and clinical outcome
Epilepsy Res, 129, 125-131
DOI 10.1016/j.eplepsyres.2016.12.001, PubMed 28043062
Publications 2015
Availability of antiepileptic drugs across Europe
Epilepsia, 56 (12), e191-7
DOI 10.1111/epi.13210, PubMed 26477534
Antiepileptic and Antidepressive Polypharmacy in Patients with Multiple Sclerosis
Mult Scler Int, 2015, 317859
DOI 10.1155/2015/317859, PubMed 26221541
Experience from therapeutic drug monitoring and gender aspects of gabapentin and pregabalin in clinical practice
Seizure, 28, 88-91
DOI 10.1016/j.seizure.2015.02.017, PubMed 25758302
Pharmacotherapy in epilepsy - does gender affect safety?
Expert Opin Drug Saf, 15 (1), 1-4
DOI 10.1517/14740338.2016.1117606, PubMed 26650146
Publications 2013
Withdrawal of antiepileptic drugs during presurgical video-EEG monitoring: an observational study for evaluation of current practice at a referral center for epilepsy
Acta Neurol Scand, 129 (4), 243-51
DOI 10.1111/ane.12179, PubMed 23980664
Pharmacological treatment of psychiatric comorbidity in patients with refractory epilepsy
Epilepsy Behav, 29 (1), 77-81
DOI 10.1016/j.yebeh.2013.06.031, PubMed 23939032
Epilepsy, cognition, and neuropsychiatry (Epilepsy, Brain, and Mind, part 2)
Epilepsy Behav, 28 (2), 283-302
DOI 10.1016/j.yebeh.2013.03.012, PubMed 23764496
[Electronic prescriptions and cooperation]
Tidsskr Nor Laegeforen, 133 (2), 133
DOI 10.4045/tidsskr.12.1471, PubMed 23344589
Antiepileptic drug treatment in pregnancy: changes in drug disposition and their clinical implications
Epilepsia, 54 (3), 405-14
DOI 10.1111/epi.12109, PubMed 23360413
Publications 2012
Pharmacokinetic variability of four newer antiepileptic drugs, lamotrigine, levetiracetam, oxcarbazepine, and topiramate: a comparison of the impact of age and comedication
Ther Drug Monit, 34 (4), 440-5
DOI 10.1097/FTD.0b013e31825ee389, PubMed 22777154
Methodologies used to identify and characterize interactions among antiepileptic drugs
Expert Rev Clin Pharmacol, 5 (3), 281-92
DOI 10.1586/ecp.12.10, PubMed 22697591
Publications 2011
Host factors affecting antiepileptic drug delivery-pharmacokinetic variability
Adv Drug Deliv Rev, 64 (10), 896-910
DOI 10.1016/j.addr.2011.10.003, PubMed 22063021
[The prescription registry and abuse of pregabalin]
Tidsskr Nor Laegeforen, 131 (3), 223
DOI 10.4045/tidsskr.10.1328, PubMed 21304565
Prescription patterns of antiepileptic drugs in patients with epilepsy in a nation-wide population
Epilepsy Res, 95 (1-2), 51-9
DOI 10.1016/j.eplepsyres.2011.02.012, PubMed 21435840
Safety aspects of antiepileptic drugs--focus on pharmacovigilance
Pharmacoepidemiol Drug Saf, 21 (1), 11-20
DOI 10.1002/pds.2269, PubMed 22069221
[Clarification about pregabalin and the Norwegian Prescription Database]
Tidsskr Nor Laegeforen, 131 (8), 800-1
DOI 10.4045/tidsskr.11.0292, PubMed 21556068
Publications 2010
Drug interactions involving the new second- and third-generation antiepileptic drugs
Expert Rev Neurother, 10 (1), 119-40
DOI 10.1586/ern.09.136, PubMed 20021326
Antiepileptic drug interactions - principles and clinical implications
Curr Neuropharmacol, 8 (3), 254-67
DOI 10.2174/157015910792246254, PubMed 21358975
Psychiatric comorbidity in patients with epilepsy: a population-based study
Eur J Clin Pharmacol, 66 (11), 1151-60
DOI 10.1007/s00228-010-0861-y, PubMed 20669014
Publications 2009
Antiepileptic drugs in epilepsy and other disorders--a population-based study of prescriptions
Epilepsy Res, 87 (1), 31-9
DOI 10.1016/j.eplepsyres.2009.07.005, PubMed 19679449
Antiepileptic drug treatment of children at a referral centre for epilepsy--does admission make a difference?
Seizure, 18 (8), 573-9
DOI 10.1016/j.seizure.2009.05.011, PubMed 19576793
Publications 2008
Antiepileptic drugs in non-epilepsy disorders: relations between mechanisms of action and clinical efficacy
CNS Drugs, 22 (1), 27-47
DOI 10.2165/00023210-200822010-00003, PubMed 18072813
Pharmacological management of epilepsy: recent advances and future prospects
Drugs, 68 (14), 1925-39
DOI 10.2165/00003495-200868140-00001, PubMed 18778117
Value of therapeutic drug monitoring in epilepsy
Expert Rev Neurother, 8 (6), 929-39
DOI 10.1586/14737175.8.6.929, PubMed 18505358
Antiepileptic drugs in non-epilepsy disorders - Relations between mechanisms of action and clinical efficacy
CNS Drugs, 22 (1), 27-47
Modifications of antiepileptic drugs for improved tolerability and efficacy
Perspect Medicin Chem, 2, 21-39
PubMed 19787095
Pharmacological Management of Epilepsy Recent Advances and Future Prospects
Drugs, 68 (14), 1925-1939
Interactions between antiepileptic drugs and herbal medicines
Bol. Latinoam. Caribe Plantas M., 7 (2), 108-118
Publications 2007
Clinical use of antiepileptic drugs at a referral centre for epilepsy
Seizure, 16 (4), 356-64
DOI 10.1016/j.seizure.2007.02.006, PubMed 17420145
Publications 2006
Targets for antiepileptic drugs in the synapse
Med Sci Monit, 13 (1), RA1-7
PubMed 17179916