Morten Milek Nielsen
- Post doc
- +47 22 78 13 17
Office: K02 012
Publications 2024
RUNX2 as a novel biomarker for early identification of patients progressing to advanced-stage mycosis fungoides
Front Oncol, 14, 1421443
DOI 10.3389/fonc.2024.1421443, PubMed 39435287
Secukinumab and Dead Sea Climatotherapy Impact Resolved Psoriasis Skin Differently Potentially Affecting Disease Memory
Int J Mol Sci, 25 (11)
DOI 10.3390/ijms25116086, PubMed 38892277
circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA
Elife, 13
DOI 10.7554/eLife.91783, PubMed 39041323
circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA
bioRxiv
DOI 10.1101/2023.09.14.557527, PubMed 37745562
Publications 2023
A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo
Nat Cancer, 4 (10), 1474-1490
DOI 10.1038/s43018-023-00642-8, PubMed 37783807
Prevalent and immunodominant CD8 T cell epitopes are conserved in SARS-CoV-2 variants
Cell Rep, 42 (1), 111995
DOI 10.1016/j.celrep.2023.111995, PubMed 36656713
Sequence dependencies and mutation rates of localized mutational processes in cancer
Genome Med, 15 (1), 63
DOI 10.1186/s13073-023-01217-z, PubMed 37592287
Epigenetic Silencing of LRP2 Is Associated with Dedifferentiation and Poor Survival in Multiple Solid Tumor Types
Cancers (Basel), 15 (6)
DOI 10.3390/cancers15061830, PubMed 36980716
Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
Nature, 614 (7948), E40
DOI 10.1038/s41586-022-05599-9, PubMed 36697832
Publications 2022
Tryptophan depletion results in tryptophan-to-phenylalanine substitutants
Nature, 603 (7902), 721-727
DOI 10.1038/s41586-022-04499-2, PubMed 35264796
Author Correction: Tryptophan depletion results in tryptophan-to-phenylalanine substitutants
Nature, 608 (7922), E20
DOI 10.1038/s41586-022-05097-y, PubMed 35840685
Publications 2021
The landscape and driver potential of site-specific hotspots across cancer genomes
NPJ Genom Med, 6 (1), 33
DOI 10.1038/s41525-021-00197-6, PubMed 33986299
miRNA activity inferred from single cell mRNA expression
Sci Rep, 11 (1), 9170
DOI 10.1038/s41598-021-88480-5, PubMed 33911110
Publications 2020
Anti-tumour immunity induces aberrant peptide presentation in melanoma
Nature, 590 (7845), 332-337
DOI 10.1038/s41586-020-03054-1, PubMed 33328638
Passenger Mutations in More Than 2,500 Cancer Genomes: Overall Molecular Functional Impact and Consequences
Cell, 180 (5), 915-927.e16
DOI 10.1016/j.cell.2020.01.032, PubMed 32084333
Epigenetic and transcriptomic consequences of excess X-chromosome material in 47,XXX syndrome-A comparison with Turner syndrome and 46,XX females
Am J Med Genet C Semin Med Genet, 184 (2), 279-293
DOI 10.1002/ajmg.c.31799, PubMed 32489015
Transcriptome-wide profiles of circular RNA and RNA-binding protein interactions reveal effects on circular RNA biogenesis and cancer pathway expression
Genome Med, 12 (1), 112
DOI 10.1186/s13073-020-00812-8, PubMed 33287884
Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
Nature, 578 (7793), 102-111
DOI 10.1038/s41586-020-1965-x, PubMed 32025015
Epigenetics and genomics in Klinefelter syndrome
Am J Med Genet C Semin Med Genet, 184 (2), 216-225
DOI 10.1002/ajmg.c.31802, PubMed 32484281
Publications 2019
Epigenetics and genomics in Turner syndrome
Am J Med Genet C Semin Med Genet, 181 (1), 68-75
DOI 10.1002/ajmg.c.31683, PubMed 30811826
Publications 2018
A site specific model and analysis of the neutral somatic mutation rate in whole-genome cancer data
BMC Bioinformatics, 19 (1), 147
DOI 10.1186/s12859-018-2141-2, PubMed 29673314
Pan-cancer screen for mutations in non-coding elements with conservation and cancer specificity reveals correlations with expression and survival
NPJ Genom Med, 3, 1
DOI 10.1038/s41525-017-0040-5, PubMed 29354286
APD-Containing Cyclolipodepsipeptides Target Mitochondrial Function in Hypoxic Cancer Cells
Cell Chem Biol, 25 (11), 1337-1349.e12
DOI 10.1016/j.chembiol.2018.07.010, PubMed 30122371
Crystal Structures of the <b>C</b>atalytic <b>D</b>omain of Arabidopsis thaliana Starch Synthase IV, of Granule Bound Starch Synthase From CLg1 and of Granule Bound Starch Synthase I of Cyanophora paradoxa Illustrate Substrate Recognition in Starch Synthases
Front Plant Sci, 9, 1138
DOI 10.3389/fpls.2018.01138, PubMed 30123236
Regmex: a statistical tool for exploring motifs in ranked sequence lists from genomics experiments
Algorithms Mol Biol, 13, 17
DOI 10.1186/s13015-018-0135-2, PubMed 30555524
DNA hypermethylation and differential gene expression associated with Klinefelter syndrome
Sci Rep, 8 (1), 13740
DOI 10.1038/s41598-018-31780-0, PubMed 30213969
Publications 2017
Waxy and non-waxy barley cultivars exhibit differences in the targeting and catalytic activity of GBSS1a
J Exp Bot, 68 (5), 931-941
DOI 10.1093/jxb/erw503, PubMed 28199682
Non-coding cancer driver candidates identified with a sample- and position-specific model of the somatic mutation rate
Elife, 6
DOI 10.7554/eLife.21778, PubMed 28362259
Detection of local inflammation induced by repeated exposure to contact allergens by use of IVIS SpectrumCT analyses
Contact Dermatitis, 76 (4), 210-217
DOI 10.1111/cod.12746, PubMed 28120518
γδ T cells in homeostasis and host defence of epithelial barrier tissues
Nat Rev Immunol, 17 (12), 733-745
DOI 10.1038/nri.2017.101, PubMed 28920588
Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer
NPJ Genom Med, 2, 36
DOI 10.1038/s41525-017-0038-z, PubMed 29263845
Profiling of long non-coding RNAs identifies LINC00958 and LINC01296 as candidate oncogenes in bladder cancer
Sci Rep, 7 (1), 395
DOI 10.1038/s41598-017-00327-0, PubMed 28341852
Publications 2016
SNHG16 is regulated by the Wnt pathway in colorectal cancer and affects genes involved in lipid metabolism
Mol Oncol, 10 (8), 1266-82
DOI 10.1016/j.molonc.2016.06.003, PubMed 27396952
In vitro Biochemical Characterization of All Barley Endosperm Starch Synthases
Front Plant Sci, 6, 1265
DOI 10.3389/fpls.2015.01265, PubMed 26858729
SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization
Nat Commun, 7, 13875
DOI 10.1038/ncomms13875, PubMed 28004750
IL-17A- and IFNγ-Producing T Cells in Healthy Skin
Scand J Immunol, 83 (4), 297-9
DOI 10.1111/sji.12412, PubMed 26808020
Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma
Cancer Cell, 30 (1), 27-42
DOI 10.1016/j.ccell.2016.05.004, PubMed 27321955
miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells
Nat Commun, 7, 12436
DOI 10.1038/ncomms12436, PubMed 27526785
Rapid allergen-induced interleukin-17 and interferon-γ secretion by skin-resident memory CD8+ T cells
Contact Dermatitis, 76 (4), 218-227
DOI 10.1111/cod.12715, PubMed 27873334
Widespread DNA hypomethylation and differential gene expression in Turner syndrome
Sci Rep, 6, 34220
DOI 10.1038/srep34220, PubMed 27687697
Publications 2015
Nickel acts as an adjuvant during cobalt sensitization
Exp Dermatol, 24 (3), 229-31
DOI 10.1111/exd.12634, PubMed 25580744
Prolonged erythropoietin treatment does not impact gene expression in human skeletal muscle
Muscle Nerve, 51 (4), 554-61
DOI 10.1002/mus.24355, PubMed 25088500
Surface binding sites in amylase have distinct roles in recognition of starch structure motifs and degradation
Int J Biol Macromol, 75, 338-45
DOI 10.1016/j.ijbiomac.2015.01.054, PubMed 25661878
The lncRNA MIR31HG regulates p16(INK4A) expression to modulate senescence
Nat Commun, 6, 6967
DOI 10.1038/ncomms7967, PubMed 25908244
NKG2D-dependent activation of dendritic epidermal T cells in contact hypersensitivity
J Invest Dermatol, 135 (5), 1311-1319
DOI 10.1038/jid.2015.23, PubMed 25634359
The Role of Cysteine Residues in Redox Regulation and Protein Stability of Arabidopsis thaliana Starch Synthase 1
PLoS One, 10 (9), e0136997
DOI 10.1371/journal.pone.0136997, PubMed 26367870
Publications 2014
Midline 1 controls polarization and migration of murine cytotoxic T cells
Immun Inflamm Dis, 2 (4), 262-71
DOI 10.1002/iid3.44, PubMed 25866633
An immune response study of oakmoss absolute and its constituents atranol and chloroatranol
Contact Dermatitis, 70 (5), 282-90
DOI 10.1111/cod.12177, PubMed 24460794
A dual program for translation regulation in cellular proliferation and differentiation
Cell, 158 (6), 1281-1292
DOI 10.1016/j.cell.2014.08.011, PubMed 25215487
IL-1β-dependent activation of dendritic epidermal T cells in contact hypersensitivity
J Immunol, 192 (7), 2975-83
DOI 10.4049/jimmunol.1301689, PubMed 24600030
Immune responses to hair dyes containing toluene-2,5-diamine
Br J Dermatol, 170 (2), 352-9
DOI 10.1111/bjd.12676, PubMed 24124869
Epicutaneous exposure to nickel induces nickel allergy in mice via a MyD88-dependent and interleukin-1-dependent pathway
Contact Dermatitis, 71 (4), 224-32
DOI 10.1111/cod.12270, PubMed 25040758
Publications 2013
Structure of starch synthase I from barley: insight into regulatory mechanisms of starch synthase activity
Acta Crystallogr D Biol Crystallogr, 69 (Pt 6), 1013-25
DOI 10.1107/S090744491300440X, PubMed 23695246
Bone microarchitecture and estimated strength in 499 adult Danish women and men: a cross-sectional, population-based high-resolution peripheral quantitative computed tomographic study on peak bone structure
Calcif Tissue Int, 94 (3), 269-81
DOI 10.1007/s00223-013-9808-5, PubMed 24146226
Identification of expressed and conserved human noncoding RNAs
RNA, 20 (2), 236-51
DOI 10.1261/rna.038927.113, PubMed 24344320
Publications 2012
Barley callus: a model system for bioengineering of starch in cereals
Plant Methods, 8 (1), 36
DOI 10.1186/1746-4811-8-36, PubMed 22958600
The Danish Twin Registry: linking surveys, national registers, and biological information
Twin Res Hum Genet, 16 (1), 104-11
DOI 10.1017/thg.2012.77, PubMed 23084092
Publications 2011
Enhanced sensitization and elicitation responses caused by mixtures of common fragrance allergens
Contact Dermatitis, 65 (6), 336-42
DOI 10.1111/j.1600-0536.2011.01945.x, PubMed 21767274
Substrate and metal ion promiscuity in mannosylglycerate synthase
J Biol Chem, 286 (17), 15155-64
DOI 10.1074/jbc.M110.199844, PubMed 21288903
A DNA tile actuator with eleven discrete states
Angew Chem Int Ed Engl, 50 (17), 3983-7
DOI 10.1002/anie.201007642, PubMed 21425422
Publications 2010
Polymorphisms of the T cell receptor CD3delta and CD3epsilon chains affect anti-CD3 antibody binding and T cell activation
Mol Immunol, 47 (15), 2450-7
DOI 10.1016/j.molimm.2010.06.012, PubMed 20638133
Site-specific chemical labeling of long RNA molecules
Bioconjug Chem, 22 (1), 95-100
DOI 10.1021/bc100422k, PubMed 21138255
Repeated exposure to hair dye induces regulatory T cells in mice
Br J Dermatol, 163 (5), 992-8
DOI 10.1111/j.1365-2133.2010.09988.x, PubMed 20716223
Publications 2009
Self-assembly of a nanoscale DNA box with a controllable lid
Nature, 459 (7243), 73-6
DOI 10.1038/nature07971, PubMed 19424153
TCR down-regulation controls T cell homeostasis
J Immunol, 183 (8), 4994-5005
DOI 10.4049/jimmunol.0901539, PubMed 19801521
Two secondary carbohydrate binding sites on the surface of barley alpha-amylase 1 have distinct functions and display synergy in hydrolysis of starch granules
Biochemistry, 48 (32), 7686-97
DOI 10.1021/bi900795a, PubMed 19606835
Publications 2008
DNA origami design of dolphin-shaped structures with flexible tails
ACS Nano, 2 (6), 1213-8
DOI 10.1021/nn800215j, PubMed 19206339
New candidate genes for heat resistance in Drosophila melanogaster are regulated by HSF
Cell Stress Chaperones, 13 (2), 177-82
DOI 10.1007/s12192-008-0020-x, PubMed 18759003
Multi-site substrate binding and interplay in barley alpha-amylase 1
FEBS Lett, 582 (17), 2567-71
DOI 10.1016/j.febslet.2008.06.027, PubMed 18588886
Publications 2007
The 'pair of sugar tongs' site on the non-catalytic domain C of barley alpha-amylase participates in substrate binding and activity
FEBS J, 274 (19), 5055-67
DOI 10.1111/j.1742-4658.2007.06024.x, PubMed 17803687
Publications 2006
Phototransduction genes are up-regulated in a global gene expression study of Drosophila melanogaster selected for heat resistance
Cell Stress Chaperones, 11 (4), 325-33
DOI 10.1379/csc-207.1, PubMed 17278881
Publications 2005
[Primary hyperparathyroidism in pregnancy]
Ugeskr Laeger, 167 (37), 3510-1
PubMed 16159462
Role of HSF activation for resistance to heat, cold and high-temperature knock-down
J Insect Physiol, 51 (12), 1320-9
DOI 10.1016/j.jinsphys.2005.08.002, PubMed 16169555
Full genome gene expression analysis of the heat stress response in Drosophila melanogaster
Cell Stress Chaperones, 10 (4), 312-28
DOI 10.1379/csc-128r1.1, PubMed 16333985