Stine Knudsen

  • Neurologist PhD
  • +47 23 01 60 30

Publications 2019

Juvodden HT, Alnæs D, Lund MJ, Dietrichs E, Thorsby PM, Westlye LT, Knudsen S (2019)
Hypocretin-deficient narcolepsy patients have abnormal brain activation during humor processing
Sleep (in press)
DOI 10.1093/sleep/zsz082, PubMed 30923809

Nordstrand SEH, Hansen BH, Rootwelt T, Karlsen TI, Swanson D, Nilsen KB, Knudsen S (2019)
Psychiatric symptoms in patients with post-H1N1 narcolepsy type 1 in Norway
Sleep, 42 (4)
DOI 10.1093/sleep/zsz008, PubMed 30649483

Pedersen NW, Holm A, Kristensen NP, Bjerregaard AM, Bentzen AK, Marquard AM, Tamhane T, Burgdorf KS, Ullum H, Jennum P, Knudsen S, Hadrup SR, Kornum BR (2019)
CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens
Nat Commun, 10 (1), 837
DOI 10.1038/s41467-019-08774-1, PubMed 30783092

Publications 2018

Engstrom M, Aarrestad S, Eldoen G, Alme A, Bjorge T, Miljeteig H, Bjorvatn B, Knudsen S, Indrekvam S, Nilsen KB (2018)
New recommendations for objective examination of sleep and sleep disorders
Tidsskr. Nor. Laegeforen., 138 (19), 1805-1806

Engstrøm M, Aarrestad S, Eldøen G, Alme A, Bjørge T, Miljeteig H, Bjorvatn B, Knudsen S, Indrekvam S, Nilsen KB (2018)
New recommendations for objective investigation of sleep and sleep disorders
Tidsskr Nor Laegeforen, 138 (19)
DOI 10.4045/tidsskr.18.0741, PubMed 30497241

Juvodden HT, Alnæs D, Lund MJ, Agartz I, Andreassen OA, Dietrichs E, Thorsby PM, Westlye LT, Knudsen S (2018)
Widespread white matter changes in post-H1N1 patients with narcolepsy type 1 and first-degree relatives
Sleep, 41 (10)
DOI 10.1093/sleep/zsy145, PubMed 30016530

Nordstrand SH, Hansen BH, Kamaleri Y, Nilsen KB, Rootwelt T, Karlsen TI, Knudsen S (2018)
Changes in quality of life in individuals with narcolepsy type 1 after the H1N1-influenza epidemic and vaccination campaign in Norway: a two-year prospective cohort study
Sleep Med, 50, 175-180
DOI 10.1016/j.sleep.2018.05.037, PubMed 30075393

Publications 2017

Kornum BR, Burgdorf KS, Holm A, Ullum H, Jennum P, Knudsen S (2017)
Absence of autoreactive CD4+ T-cells targeting HLA-DQA1*01:02/DQB1*06:02 restricted hypocretin/orexin epitopes in narcolepsy type 1 when detected by EliSpot
J Neuroimmunol, 309, 7-11
DOI 10.1016/j.jneuroim.2017.05.001, PubMed 28601291

Kornum BR, Knudsen S, Ollila HM, Pizza F, Jennum PJ, Dauvilliers Y, Overeem S (2017)
Nat Rev Dis Primers, 3, 16100
DOI 10.1038/nrdp.2016.100, PubMed 28179647

Schrölkamp M, Jennum PJ, Gammeltoft S, Holm A, Kornum BR, Knudsen S (2017)
Normal Morning Melanin-Concentrating Hormone Levels and No Association with Rapid Eye Movement or Non-Rapid Eye Movement Sleep Parameters in Narcolepsy Type 1 and Type 2
J Clin Sleep Med, 13 (2), 235-243
DOI 10.5664/jcsm.6454, PubMed 27855741

Viste R, Soosai J, Vikin T, Thorsby PM, Nilsen KB, Knudsen S (2017)
Long-term improvement after combined immunomodulation in early post-H1N1 vaccination narcolepsy
Neurol Neuroimmunol Neuroinflamm, 4 (5), e389
DOI 10.1212/NXI.0000000000000389, PubMed 28840177

Publications 2016

Jennum PJ, Kornum BR, Issa NM, Gammeltoft S, Tommerup N, Morling N, Tümer Z, Knudsen S (2016)
Monozygotic twins discordant for narcolepsy type 1 and multiple sclerosis
Neurol Neuroimmunol Neuroinflamm, 3 (4), e249
DOI 10.1212/NXI.0000000000000249, PubMed 27354986

Publications 2015

Kornum BR, Pizza F, Knudsen S, Plazzi G, Jennum P, Mignot E (2015)
Cerebrospinal fluid cytokine levels in type 1 narcolepsy patients very close to onset
Brain Behav Immun, 49, 54-8
DOI 10.1016/j.bbi.2015.03.004, PubMed 25771509

Ollila HM, Ravel JM, Han F, Faraco J, Lin L, Zheng X, Plazzi G, Dauvilliers Y, Pizza F, Hong SC, Jennum P, Knudsen S, Kornum BR, Dong XS, Yan H, Hong H, Coquillard C, Mahlios J, Jolanki O, Einen M, Arnulf I, Högl B, Frauscher B, Crowe C, Partinen M et al. (2015)
HLA-DPB1 and HLA class I confer risk of and protection from narcolepsy
Am J Hum Genet, 96 (1), 136-46
DOI 10.1016/j.ajhg.2014.12.010, PubMed 25574827

Publications 2014

Barloese M, Jennum P, Lund N, Knudsen S, Gammeltoft S, Jensen R (2014)
Reduced CSF hypocretin-1 levels are associated with cluster headache
Cephalalgia, 35 (10), 869-76
DOI 10.1177/0333102414562971, PubMed 25492975

Han F, Lin L, Schormair B, Pizza F, Plazzi G, Ollila HM, Nevsimalova S, Jennum P, Knudsen S, Winkelmann J, Coquillard C, Babrzadeh F, Strom TM, Wang C, Mindrinos M, Fernandez Vina M, Mignot E (2014)
HLA DQB1*06:02 negative narcolepsy with hypocretin/orexin deficiency
Sleep, 37 (10), 1601-8
DOI 10.5665/sleep.4066, PubMed 25197808

Holm A, Bang-Berthelsen CH, Knudsen S, Kornum BR, Modvig S, Jennum P, Gammeltoft S (2014)
miRNA profiles in plasma from patients with sleep disorders reveal dysregulation of miRNAs in narcolepsy and other central hypersomnias
Sleep, 37 (9), 1525-33
DOI 10.5665/sleep.4004, PubMed 25142559

Holm A, Bang-Berthelsen CH, Knudsen S, Modvig S, Kornum BR, Gammeltoft S, Jennum PJ (2014)
MiRNA profiles in cerebrospinal fluid from patients with central hypersomnias
J Neurol Sci, 347 (1-2), 199-204
DOI 10.1016/j.jns.2014.09.047, PubMed 25451005

Jensen JB, Sorensen HB, Kempfner J, Sørensen GL, Knudsen S, Jennum P (2014)
Sleep-wake transition in narcolepsy and healthy controls using a support vector machine
J Clin Neurophysiol, 31 (5), 397-401
DOI 10.1097/WNP.0000000000000074, PubMed 25271675

Publications 2013

Heier MS, Gjerstad MD, Knudsen S (2013)
[New knowledge about narcolepsy in children]
Tidsskr Nor Laegeforen, 133 (12-13), 1326-8
DOI 10.4045/tidsskr.13.0414, PubMed 23817265

Jennum P, Ibsen R, Knudsen S, Kjellberg J (2013)
Comorbidity and mortality of narcolepsy: a controlled retro- and prospective national study
Sleep, 36 (6), 835-40
DOI 10.5665/sleep.2706, PubMed 23729926

Klein AB, Jennum P, Knudsen S, Gammeltoft S, Mikkelsen JD (2013)
Increased serum brain-derived neurotrophic factor (BDNF) levels in patients with narcolepsy
Neurosci Lett, 544, 31-5
DOI 10.1016/j.neulet.2013.03.031, PubMed 23570723

Kornum BR, Knudsen S, Gammeltoft S, Jennum P (2013)
[The association between narcolepsy and H1N1 influenza]
Ugeskr Laeger, 175 (12), 815
PubMed 23582821

Luca G, Haba-Rubio J, Dauvilliers Y, Lammers GJ, Overeem S, Donjacour CE, Mayer G, Javidi S, Iranzo A, Santamaria J, Peraita-Adrados R, Hor H, Kutalik Z, Plazzi G, Poli F, Pizza F, Arnulf I, Lecendreux M, Bassetti C, Mathis J, Heinzer R, Jennum P, Knudsen S, Geisler P, Wierzbicka A et al. (2013)
Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study
J Sleep Res, 22 (5), 482-95
DOI 10.1111/jsr.12044, PubMed 23496005

Savvidou A, Knudsen S, Olsson-Engman M, Gammeltoft S, Jennum P, Palm L (2013)
Hypocretin deficiency develops during onset of human narcolepsy with cataplexy
Sleep, 36 (1), 147-8
DOI 10.5665/sleep.2320, PubMed 23288981

Sorensen GL, Knudsen S, Jennum P (2013)
Sleep transitions in hypocretin-deficient narcolepsy
Sleep, 36 (8), 1173-7
DOI 10.5665/sleep.2880, PubMed 23904677

Sorensen GL, Knudsen S, Petersen ER, Kempfner J, Gammeltoft S, Sorensen HB, Jennum P (2013)
Attenuated heart rate response is associated with hypocretin deficiency in patients with narcolepsy
Sleep, 36 (1), 91-8
DOI 10.5665/sleep.2308, PubMed 23288975

Publications 2012

Andlauer O, Moore H, Hong SC, Dauvilliers Y, Kanbayashi T, Nishino S, Han F, Silber MH, Rico T, Einen M, Kornum BR, Jennum P, Knudsen S, Nevsimalova S, Poli F, Plazzi G, Mignot E (2012)
Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy
Sleep, 35 (9), 1247-55F
DOI 10.5665/sleep.2080, PubMed 22942503

Jennum P, Ibsen R, Petersen ER, Knudsen S, Kjellberg J (2012)
Health, social, and economic consequences of narcolepsy: a controlled national study evaluating the societal effect on patients and their partners
Sleep Med, 13 (8), 1086-93
DOI 10.1016/j.sleep.2012.06.006, PubMed 22841027

Knudsen S, Biering-Sørensen B, Kornum BR, Petersen ER, Ibsen JD, Gammeltoft S, Mignot E, Jennum PJ (2012)
Early IVIg treatment has no effect on post-H1N1 narcolepsy phenotype or hypocretin deficiency
Neurology, 79 (1), 102-3
DOI 10.1212/WNL.0b013e31825dce03, PubMed 22722630

Publications 2010

Hor H, Kutalik Z, Dauvilliers Y, Valsesia A, Lammers GJ, Donjacour CE, Iranzo A, Santamaria J, Peraita Adrados R, Vicario JL, Overeem S, Arnulf I, Theodorou I, Jennum P, Knudsen S, Bassetti C, Mathis J, Lecendreux M, Mayer G, Geisler P, Benetó A, Petit B, Pfister C, Bürki JV, Didelot G et al. (2010)
Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy
Nat Genet, 42 (9), 786-9
DOI 10.1038/ng.647, PubMed 20711174

Kawashima M, Lin L, Tanaka S, Jennum P, Knudsen S, Nevsimalova S, Plazzi G, Mignot E (2010)
Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy
Sleep, 33 (7), 869-74
DOI 10.1093/sleep/33.7.869, PubMed 20614846

Knudsen S, Gammeltoft S, Jennum PJ (2010)
Rapid eye movement sleep behaviour disorder in patients with narcolepsy is associated with hypocretin-1 deficiency
Brain, 133 (Pt 2), 568-79
DOI 10.1093/brain/awp320, PubMed 20129934

Knudsen S, Jennum PJ, Alving J, Sheikh SP, Gammeltoft S (2010)
Validation of the ICSD-2 criteria for CSF hypocretin-1 measurements in the diagnosis of narcolepsy in the Danish population
Sleep, 33 (2), 169-76
DOI 10.1093/sleep/33.2.169, PubMed 20175400

Knudsen S, Zoetmulder M, Jennum P (2010)
[Disturbed rapid eye movement-sleep predicts neurodegenerative disease]
Ugeskr Laeger, 172 (12), 963
PubMed 20334797

Kornum BR, Kawashima M, Faraco J, Lin L, Rico TJ, Hesselson S, Axtell RC, Kuipers H, Weiner K, Hamacher A, Kassack MU, Han F, Knudsen S, Li J, Dong X, Winkelmann J, Plazzi G, Nevsimalova S, Hong SC, Honda Y, Honda M, Högl B, Ton TG, Montplaisir J, Bourgin P et al. (2010)
Common variants in P2RY11 are associated with narcolepsy
Nat Genet, 43 (1), 66-71
DOI 10.1038/ng.734, PubMed 21170044

Publications 2009

Jennum P, Knudsen S, Kjellberg J (2009)
The economic consequences of narcolepsy
J Clin Sleep Med, 5 (3), 240-5
PubMed 19960645

Publications 2007

Knudsen S, Mikkelsen JD, Jennum P (2007)
Antibodies in narcolepsy-cataplexy patient serum bind to rat hypocretin neurons
Neuroreport, 18 (1), 77-9
DOI 10.1097/WNR.0b013e328010baad, PubMed 17259865

Publications 2006

Knudsen S, Jennum PJ (2006)
[Narcolepsy--new implications of molecular biology]
Ugeskr Laeger, 168 (43), 3699-704
PubMed 17069732

Nielsen K, Rostrup E, Frederiksen JL, Knudsen S, Mathiesen HK, Hanson LG, Paulson OB (2006)
Magnetic resonance imaging at 3.0 tesla detects more lesions in acute optic neuritis than at 1.5 tesla
Invest Radiol, 41 (2), 76-82
PubMed 16428976

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