Publications 2024

Bergh MS, Bogen IL, Grafinger KE, Huestis MA, Øiestad ÅML (2024)
Metabolite markers for three synthetic tryptamines N-ethyl-N-propyltryptamine, 4-hydroxy-N-ethyl-N-propyltryptamine, and 5-methoxy-N-ethyl-N-propyltryptamine
Drug Test Anal, 16 (12), 1544-1557
DOI 10.1002/dta.3668, PubMed 38459837

Bojarskaite L, Nafari S, Ravnanger AK, Frey MM, Skauli N, Åbjørsbråten KS, Roth LC, Amiry-Moghaddam M, Nagelhus EA, Ottersen OP, Bogen IL, Thoren AE, Enger R (2024)
Role of aquaporin-4 polarization in extracellular solute clearance
Fluids Barriers CNS, 21 (1), 28
DOI 10.1186/s12987-024-00527-7, PubMed 38532513

Nyberg H, Bogen IL, Nygaard E, Achterberg M, Andersen JM (2024)
Maternal exposure to buprenorphine, but not methadone, during pregnancy reduces social play behavior across two generations of offspring
Psychopharmacology (Berl) (in press)
DOI 10.1007/s00213-024-06718-2, PubMed 39633163

Nyberg H, Bogen IL, Nygaard E, Andersen JM (2024)
Effects of prenatal exposure to methadone or buprenorphine and maternal separation on anxiety-like behavior in rats
Drug Alcohol Depend, 262, 111367
DOI 10.1016/j.drugalcdep.2024.111367, PubMed 39003831

Publications 2023

Bogen IL, Boix F, Andersen JM, Steinsland S, Nerem E, Mørland J (2023)
Heroin metabolism in human blood and its impact for the design of an immunotherapeutic approach against heroin effects
Basic Clin Pharmacol Toxicol, 133 (4), 418-427
DOI 10.1111/bcpt.13926, PubMed 37452619

Harrison SP, Siller R, Tanaka Y, Chollet ME, de la Morena-Barrio ME, Xiang Y, Patterson B, Andersen E, Bravo-Pérez C, Kempf H, Åsrud KS, Lunov O, Dejneka A, Mowinckel MC, Stavik B, Sandset PM, Melum E, Baumgarten S, Bonanini F, Kurek D, Mathapati S, Almaas R, Sharma K, Wilson SR, Skottvoll FS et al. (2023)
Scalable production of tissue-like vascularized liver organoids from human PSCs
Exp Mol Med, 55 (9), 2005-2024
DOI 10.1038/s12276-023-01074-1, PubMed 37653039

Publications 2022

Kogler S, Aizenshtadt A, Harrison S, Skottvoll FS, Berg HE, Abadpour S, Scholz H, Sullivan G, Thiede B, Lundanes E, Bogen IL, Krauss S, Røberg-Larsen H, Wilson SR (2022)
"Organ-in-a-Column" Coupled On-line with Liquid Chromatography-Mass Spectrometry
Anal Chem, 94 (50), 17677-17684
DOI 10.1021/acs.analchem.2c04530, PubMed 36484723

Publications 2021

Andersen JM, Bogen IL, Karinen R, Brochmann GW, Mørland J, Vindenes V, Boix F (2021)
Does the preparation for intravenous administration affect the composition of heroin injections? A controlled laboratory study
Addiction, 116 (11), 3104-3112
DOI 10.1111/add.15492, PubMed 33739552

Bergh MS, Bogen IL, Garibay N, Baumann MH (2021)
Pharmacokinetics and pharmacodynamics of cyclopropylfentanyl in male rats
Psychopharmacology (Berl), 238 (12), 3629-3641
DOI 10.1007/s00213-021-05981-x, PubMed 34613431

Bergh MSS, Bogen IL, Nerem E, Wohlfarth A, Wilson SR, Oiestad AML (2021)
Discovering the major metabolites of the three novel fentanyl analogues 3-methylcrotonylfentanyl, furanylbenzylfentanyl, and 4-fluorocyclopropylbenzylfentanyl for forensic case work
Forensic Toxicol., 39 (1), 167-178
DOI 10.1007/s11419-020-00560-9

Skottvoll FS, Hansen FA, Harrison S, Boger IS, Mrsa A, Restan MS, Stein M, Lundanes E, Pedersen-Bjergaard S, Aizenshtadt A, Krauss S, Sullivan G, Bogen IL, Wilson SR (2021)
Electromembrane Extraction and Mass Spectrometry for Liver Organoid Drug Metabolism Studies
Anal Chem, 93 (7), 3576-3585
DOI 10.1021/acs.analchem.0c05082, PubMed 33534551

Tuv SS, Bergh MS, Andersen JM, Steinsland S, Vindenes V, Baumann MH, Huestis MA, Bogen IL (2021)
Comparative Neuropharmacology and Pharmacokinetics of Methamphetamine and Its Thiophene Analog Methiopropamine in Rodents
Int J Mol Sci, 22 (21)
DOI 10.3390/ijms222112002, PubMed 34769427

Publications 2020

Bergh MS, Øiestad ÅML, Baumann MH, Bogen IL (2020)
Selectivity and sensitivity of urine fentanyl test strips to detect fentanyl analogues in illicit drugs
Int J Drug Policy, 90, 103065
DOI 10.1016/j.drugpo.2020.103065, PubMed 33333419

Kongstorp M, Bogen IL, Steinsland S, Nerem E, Salih TW, Stiris T, Andersen JM (2020)
Prenatal exposure to methadone or buprenorphine alters µ-opioid receptor binding and downstream signaling in the rat brain
Int J Dev Neurosci, 80 (5), 443-453
DOI 10.1002/jdn.10043, PubMed 32484968

Kongstorp M, Bogen IL, Stiris T, Andersen JM (2020)
Prenatal exposure to methadone or buprenorphine impairs cognitive performance in young adult rats
Drug Alcohol Depend, 212, 108008
DOI 10.1016/j.drugalcdep.2020.108008, PubMed 32402939

Publications 2019

Bergh MS, Bogen IL, Garibay N, Baumann MH (2019)
Evidence for nonlinear accumulation of the ultrapotent fentanyl analog, carfentanil, after systemic administration to male rats
Neuropharmacology, 158, 107596
DOI 10.1016/j.neuropharm.2019.04.002, PubMed 30965021

Bergh MS, Bogen IL, Wohlfarth A, Wilson SR, Øiestad ÅML (2019)
Distinguishing Between Cyclopropylfentanyl and Crotonylfentanyl by Methods Commonly Available in the Forensic Laboratory
Ther Drug Monit, 41 (4), 519-527
DOI 10.1097/FTD.0000000000000617, PubMed 30807539

Kongstorp M, Bogen IL, Stiris T, Andersen JM (2019)
High Accumulation of Methadone Compared with Buprenorphine in Fetal Rat Brain after Maternal Exposure
J Pharmacol Exp Ther, 371 (1), 130-137
DOI 10.1124/jpet.119.259531, PubMed 31358559

Kvello AMS, Andersen JM, Boix F, Mørland J, Bogen IL (2019)
The role of 6-acetylmorphine in heroin-induced reward and locomotor sensitization in mice
Addict Biol, 25 (2), e12727
DOI 10.1111/adb.12727, PubMed 30788879

Publications 2018

Avvisati R, Bogen IL, Andersen JM, Vindenes V, Mørland J, Badiani A, Boix F (2018)
The active heroin metabolite 6-acetylmorphine has robust reinforcing effects as assessed by self-administration in the rat
Neuropharmacology, 150, 192-199
DOI 10.1016/j.neuropharm.2018.12.023, PubMed 30578794

Bergh MS, Bogen IL, Wilson SR, Øiestad ÅML (2018)
Addressing the Fentanyl Analogue Epidemic by Multiplex UHPLC-MS/MS Analysis of Whole Blood
Ther Drug Monit, 40 (6), 738-748
DOI 10.1097/FTD.0000000000000564, PubMed 30157097

Kvello AMS, Andersen JM, Øiestad EL, Steinsland S, Aase A, Mørland J, Bogen IL (2018)
A Monoclonal Antibody against 6-Acetylmorphine Protects Female Mice Offspring from Adverse Behavioral Effects Induced by Prenatal Heroin Exposure
J Pharmacol Exp Ther, 368 (1), 106-115
DOI 10.1124/jpet.118.251504, PubMed 30361238

Publications 2017

Bergh MS, Bogen IL, Andersen JM, Øiestad ÅML, Berg T (2017)
Determination of adrenaline, noradrenaline and corticosterone in rodent blood by ion pair reversed phase UHPLC-MS/MS
J Chromatogr B Analyt Technol Biomed Life Sci, 1072, 161-172
DOI 10.1016/j.jchromb.2017.11.016, PubMed 29175696

Berntsen HF, Bogen IL, Wigestrand MB, Fonnum F, Walaas SI, Moldes-Anaya A (2017)
The fungal neurotoxin penitrem A induces the production of reactive oxygen species in human neutrophils at submicromolar concentrations
Toxicology, 392, 64-70
DOI 10.1016/j.tox.2017.10.008, PubMed 29037868

Vevelstad M, Øiestad EL, Nerem E, Arnestad M, Bogen IL (2017)
Studies on Para-Methoxymethamphetamine (PMMA) Metabolite Pattern and Influence of CYP2D6 Genetics in Human Liver Microsomes and Authentic Samples from Fatal PMMA Intoxications
Drug Metab Dispos, 45 (12), 1326-1335
DOI 10.1124/dmd.117.077263, PubMed 28978661

Publications 2016

Bergh MS, Bogen IL, Lundanes E, Øiestad ÅML (2016)
Validated methods for determination of neurotransmitters and metabolites in rodent brain tissue and extracellular fluid by reversed phase UHPLC-MS/MS
J Chromatogr B Analyt Technol Biomed Life Sci, 1028, 120-129
DOI 10.1016/j.jchromb.2016.06.011, PubMed 27336704

Berntsen HF, Fonnum F, Walaas SI, Bogen IL (2016)
Low-Chlorinated Non-Dioxin-like Polychlorinated Biphenyls Present in Blood and Breast Milk Induce Higher Levels of Reactive Oxygen Species in Neutrophil Granulocytes than High-Chlorinated Congeners
Basic Clin Pharmacol Toxicol, 119 (6), 588-597
DOI 10.1111/bcpt.12620, PubMed 27194217

Kvello AM, Andersen JM, Øiestad EL, Mørland J, Bogen IL (2016)
Pharmacological Effects of a Monoclonal Antibody against 6-Monoacetylmorphine upon Heroin-Induced Locomotor Activity and Pharmacokinetics in Mice
J Pharmacol Exp Ther, 358 (2), 181-9
DOI 10.1124/jpet.116.233510, PubMed 27217591

Vevelstad M, Øiestad EL, Bremer S, Bogen IL, Zackrisson AL, Arnestad M (2016)
Is toxicity of PMMA (paramethoxymethamphetamine) associated with cytochrome P450 pharmacogenetics?
Forensic Sci Int, 261, 137-47
DOI 10.1016/j.forsciint.2016.02.027, PubMed 26930544

Publications 2014

Bogen IL, Boix F, Nerem E, Mørland J, Andersen JM (2014)
A monoclonal antibody specific for 6-monoacetylmorphine reduces acute heroin effects in mice
J Pharmacol Exp Ther, 349 (3), 568-76
DOI 10.1124/jpet.113.212035, PubMed 24700886

Breivik T, Bogen IL, Haug KH, Fonnum F, Opstad PK, Eide DM, Myhre O (2014)
Effects of long-term exposure of 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy") on neuronal transmitter transport, brain immuno-regulatory systems and progression of experimental periodontitis in rats
Neurochem Int, 72, 30-6
DOI 10.1016/j.neuint.2014.04.002, PubMed 24726767

Viluksela M, Heikkinen P, van der Ven LT, Rendel F, Roos R, Esteban J, Korkalainen M, Lensu S, Miettinen HM, Savolainen K, Sankari S, Lilienthal H, Adamsson A, Toppari J, Herlin M, Finnilä M, Tuukkanen J, Leslie HA, Hamers T, Hamscher G, Al-Anati L, Stenius U, Dervola KS, Bogen IL, Fonnum F et al. (2014)
Toxicological profile of ultrapure 2,2',3,4,4',5,5'-heptachlorbiphenyl (PCB 180) in adult rats
PLoS One, 9 (8), e104639
DOI 10.1371/journal.pone.0104639, PubMed 25137063

Publications 2013

Berntsen HF, Wigestrand MB, Bogen IL, Fonnum F, Walaas SI, Moldes-Anaya A (2013)
Mechanisms of penitrem-induced cerebellar granule neuron death in vitro: possible involvement of GABAA receptors and oxidative processes
Neurotoxicology, 35, 129-36
DOI 10.1016/j.neuro.2013.01.004, PubMed 23313729

Publications 2012

Dervola KS, Roberg BA, Wøien G, Bogen IL, Sandvik TH, Sagvolden T, Drevon CA, Johansen EB, Walaas SI (2012)
Marine Ο-3 polyunsaturated fatty acids induce sex-specific changes in reinforcer-controlled behaviour and neurotransmitter metabolism in a spontaneously hypertensive rat model of ADHD
Behav Brain Funct, 8, 56
DOI 10.1186/1744-9081-8-56, PubMed 23228189

Wendt A, Speidel D, Danielsson A, Esguerra JL, Bogen IL, Walaas SI, Salehi A, Eliasson L (2012)
Synapsins I and II are not required for insulin secretion from mouse pancreatic β-cells
Endocrinology, 153 (5), 2112-9
DOI 10.1210/en.2011-1702, PubMed 22334712

Publications 2011

Bogen IL, Jensen V, Hvalby Ø, Walaas SI (2011)
Glutamatergic neurotransmission in the synapsin I and II double knock-out mouse
Semin Cell Dev Biol, 22 (4), 400-7
DOI 10.1016/j.semcdb.2011.07.004, PubMed 21827868

Publications 2009

Bogen IL, Haug KH, Roberg B, Fonnum F, Walaas SI (2009)
The importance of synapsin I and II for neurotransmitter levels and vesicular storage in cholinergic, glutamatergic and GABAergic nerve terminals
Neurochem Int, 55 (1-3), 13-21
DOI 10.1016/j.neuint.2009.02.006, PubMed 19428802

Publications 2008

Bogen IL, Jensen V, Hvalby O, Walaas SI (2008)
Synapsin-dependent development of glutamatergic synaptic vesicles and presynaptic plasticity in postnatal mouse brain
Neuroscience, 158 (1), 231-41
DOI 10.1016/j.neuroscience.2008.05.055, PubMed 18606212

Bogen IL, Risa Ø, Haug KH, Sonnewald U, Fonnum F, Walaas SI (2008)
Distinct changes in neuronal and astrocytic amino acid neurotransmitter metabolism in mice with reduced numbers of synaptic vesicles
J Neurochem, 105 (6), 2524-34
DOI 10.1111/j.1471-4159.2008.05344.x, PubMed 18346203

Publications 2006

Bogen IL, Boulland JL, Mariussen E, Wright MS, Fonnum F, Kao HT, Walaas SI (2006)
Absence of synapsin I and II is accompanied by decreases in vesicular transport of specific neurotransmitters
J Neurochem, 96 (5), 1458-66
DOI 10.1111/j.1471-4159.2005.03636.x, PubMed 16478532

Hallberg OE, Bogen IL, Reistad T, Haug KH, Wright MS, Fonnum F, Walaas SI (2006)
Differential development of vesicular glutamate transporters in brain: an in vitro study of cerebellar granule cells
Neurochem Int, 48 (6-7), 579-85
DOI 10.1016/j.neuint.2005.12.027, PubMed 16517018

Publications 2005

Gundersen Y, Vaagenes P, Thrane I, Bogen IL, Haug KH, Reistad T, Opstad PK (2005)
Response of circulating immune cells to major gunshot injury, haemorrhage, and acute surgery
Injury, 36 (8), 949-55
DOI 10.1016/j.injury.2004.09.021, PubMed 15982652

Gylterud Owe S, Bogen IL, Walaas SI, Storm-Mathisen J, Bergersen LH (2005)
Ultrastructural quantification of glutamate receptors at excitatory synapses in hippocampus of synapsin I+II double knock-out mice
Neuroscience, 136 (3), 769-77
DOI 10.1016/j.neuroscience.2005.08.056, PubMed 16344150

Haug KH, Bogen IL, Osmundsen H, Walaas I, Fonnum F (2005)
Effects on cholinergic markers in rat brain and blood after short and prolonged administration of donepezil
Neurochem Res, 30 (12), 1511-20
DOI 10.1007/s11064-005-8828-6, PubMed 16362770

Publications 2004

Myhre O, Sterri SH, Bogen IL, Fonnum F (2004)
Erk1/2 phosphorylation and reactive oxygen species formation via nitric oxide and Akt-1/Raf-1 crosstalk in cultured rat cerebellar granule cells exposed to the organic solvent 1,2,4-trimethylcyclohexane
Toxicol Sci, 80 (2), 296-303
DOI 10.1093/toxsci/kfh166, PubMed 15141098

Publications 2003

Bogen IL, Haug KH, Myhre O, Fonnum F (2003)
Short- and long-term effects of MDMA ("ecstasy") on synaptosomal and vesicular uptake of neurotransmitters in vitro and ex vivo
Neurochem Int, 43 (4-5), 393-400
DOI 10.1016/s0197-0186(03)00027-5, PubMed 12742084