Publications from the Center 2017

Rydning SL, Backe PH, Sousa MML, Iqbal Z, Øye AM, Sheng Y, Yang M, Lin X, Slupphaug G, Nordenmark TH, Vigeland MD, Bjørås M, Tallaksen CM, Selmer KK.
Novel UCHL1 mutations reveal new insights into ubiquitin processing. Hum Mol Genet. 2017 Mar 15;26(6):1217-1218

Morland C, Andersson KA, Haugen ØP, Hadzic A, Kleppa L, Gille A, Rinholm JE, Palibrk V, Diget EH, Kennedy LH, Stølen T, Hennestad E, Moldestad O, Cai Y, Puchades M, Offermanns S, Vervaeke K, Bjørås M, Wisløff U, Storm-Mathisen J, Bergersen LH.
Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1. Nat Commun. 2017 May 23;8:15557

Bosshard M, Aprigliano R, Gattiker C, Palibrk V, Markkanen E, Hoff Backe P, Pellegrino S, Raymond FL, Froyen G, Altmeyer M, Bjørås M, Dianov GL, van Loon B.
Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability. Sci Rep. 2017 Nov 8;7(1):15050

Kosik-Kozioł A, Costantini M, Bolek T, Szöke K, Barbetta A, Brinchmann JE, Święszkowski W.
PLA short sub-micron fiber reinforcement of 3D bioprinted alginate constructs for cartilage regeneration. Biofabrication. 2017 Nov 14;9(4):044105. doi: 10.1088/1758-5090/aa90d7

Szöke K, Danakova J, Bugzo M, Amler E, Brinchmann JE, Østrup E.
The effect of medium composition on deposition of collagen type I and expression of osteogenic genes in mesenchymal stem cells derived from human adipose tissue and bone marrow. Proc Biochem 2017;59,321-28.

Wollert KC, Meyer GP, Müller-Ehmsen J, Tschöpe C, Bonarjee V, Larsen AI, May AE, Empen K, Chorianopoulos E, Tebbe U, Waltenberger J, Mahrholdt H, Ritter B, Pirr J, Fischer D, Korf-Klingebiel M, Arseniev L, Heuft HG, Brinchmann JE, Messinger D, Hertenstein B, Ganser A, Katus HA, Felix SB, Gawaz MP, Dickstein K, Schultheiss HP, Ladage D, Greulich S, Bauersachs J.Eur Heart J. Intracoronary autologous bone marrow cell transfer after myocardial infarction: the BOOST-2 randomised placebo-controlled clinical trial. 2017 Oct 14;38(39):2936-2943. doi: 10.1093/eurheartj/ehx188

Behnan J, Stangeland B, Hosainey SAM, Joel M, Olsen TK, Micci F, Glover JC, Isakson P, Brinchmann JE. Differential propagation of stroma and cancer stem cells dictates tumorigenesis and multipotency. Oncogene. 2017 Jan 26;36(4):570-584

Karlsen TA, Jakobsen RB, Brinchmann JE. Early molecular events during in vitro chondrogenesis. In The Biology and Therapeutic Application of Mesenchymal Cells (ed K. Atkinson), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118907474.ch14

Paulsen J, Sekelja M, Oldenburg AR, Barateau A, Briand N, Delbarre E, Shah, A, Sørensen AL, Vigouroux C, Buendia B, Collas P. 2017. Chrom3D: three-dimensional genome modeling from Hi-C and nuclear lamin-genome contacts. Genome Biol. 18, 21-29

Guénantin AC, Briand N, Capel E, Dumont F, Morichon R, Provost C, Stillitano F, Jeziorowska D, Siffroi JP, Hajjar RJ, Fève B, Hulot JS, Collas P, Capeau J, Vigouroux C. 2017. Functional human beige adipocytes from induced pluripotent stem cells. Diabetes 66, 1470-1478

Delbarre, E, Ivanauskiene K, Spirkoski J, Shah A, Vekterud K, Moskaug JØ, Bøe SO, Wong L, Küntziger T, Collas P. 2017. PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX. Genome Res. 27, 913-921

López-Soop G, Rønningen T, Rogala A, Richartz N, Blomhoff HK, Thiede B, Collas P, Küntziger T. 2017. AKAP95 interacts with nucleoporin TPR in mitosis and is important for the spindle assembly checkpoint. Cell Cycle 16, 947-956

Oldenburg AR, Briand N, Sørensen AL, Cahyani I, Shah A, Moskaug JØ, Collas P 2017. A lipodystrophy-causing lamin A mutant alters conformation and epigenetic regulation of the anti-adipogenic MIR335 locus. J Cell Biol. 216, 2731-2743

Garcia-Nieto PE, Schwartz E, King DA, Paulsen J, Collas P, Herrera RE, Morrison AJ. 2017.
Carcinogen susceptibility is regulated by genome architecture and dictates cancer mutagenenesis. EMBO J. 36, 2839-2843

Meier M, Grant J, Dowdle A, Thomas A, Gerton J, Collas P, O'Sullivan JM, Horsfield JA. 2017.
Cohesin facilitates zygotic genome activation in zebrafish. Development. doi: 10.1242/dev.156521

Züchner M, Kondratskaya E, Sylte CB, Glover JC, Boulland JL. Rapid recovery and altered neurochemical dependence of locomotor central pattern generation following lumbar neonatal spinal cord injury. J Physiol. 2018 Jan 15;596(2):281-303. doi: 10.1113/JP274484. Epub 2017 Dec 3.

Chagnaud BP, Engelmann J, Fritzsch B, Glover JC, Straka H. Sensing External and Self-Motion with Hair Cells: A Comparison of the Lateral Line and Vestibular Systems from a Developmental and Evolutionary Perspective.Brain Behav Evol. 2017;90(2):98-116. doi: 10.1159/000456646. Epub 2017 Oct 9.

Fritzsch B, Elliott KL, Glover JC. Gaskell revisited: new insights into spinal autonomics necessitate a revised motor neuron nomenclature. Cell Tissue Res. 2017 Nov;370(2):195-209. doi: 10.1007/s00441-017-2676-y. Epub 2017 Aug 31. Review.

Chawla RS, Züchner M, Mastrangelopoulou M, Lambert FM, Glover JC, Boulland JL.
Cellular reactions and compensatory tissue re-organization during spontaneous recovery after spinal cord injury in neonatal mice. Dev Neurobiol. 2017 Sep;77(8):928-946. doi: 10.1002/dneu.22479. Epub 2017 Feb 17.

Tang C, Klukovich R, Peng H, Wang Z, Yu T, Zhang Y, Zheng H, Klungland A, Yan W. ALKBH5-dependent m6A demethylation controls splicing and stability of long 3'-UTR mRNAs in male germ cells. Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E325-E333

Pawar T, Bjørås M, Klungland A, Eide L. Metabolism and DNA repair shape a specific modification pattern in mitochondrial DNA. Mitochondrion. 2017 Sep 8. pii: S1567-7249(17)30208-8

Seifermann M, Ulges A, Bopp T, Melcea S, Schäfer A, Oka S, Nakabeppu Y, Klungland A, Niehrs C, Epe B.
Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes. DNA Repair (Amst). 2017 Oct;58:13-20.

Jordan JJ, Chhim S, Margulies CM, Allocca M, Bronson RT, Klungland A, Samson LD, Fu D. ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage. Cell Death Dis. 2017 Jul 20;8(7):e2947.

Rolseth V, Luna L, Olsen AK, Suganthan R, Scheffler K, Neurauter CG, Esbensen Y, Kuśnierczyk A, Hildrestrand GA, Graupner A, Andersen JM, Slupphaug G, Klungland A, Nilsen H, Bjørås M. No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice. Sci Rep. 2017 Jun 29;7(1):4384

Landfors M, Johansen J, Aronsen JM, Vågbø CB, Doré LC, He C, Sjaastad I, Sætrom P, Fedorcsák P, Dahl JA, Aanes H, Fußer M, Klungland A.
Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation. Cell Discov. 2017 May 9;3:17013.

Aas A, Isakson P, Bindesbøll C, Alemu EA, Klungland A, Simonsen A.
Nucleocytoplasmic Shuttling of FTO Does Not Affect Starvation-Induced Autophagy. PLoS One. 2017 Mar 13;12(3):e0168182.

Kalikstad B, Kultima HG, Andersstuen TK, Klungland A, Isaksson A. Gene expression profiles on preterm infants on continuous long‑term oxygen therapy suggest reduced oxidative stress‑dependent signaling during hypoxia. Mol Med Rep. 2017 Apr;15(4):1513-1526

Chymkowitch P, Nguéa P A, Aanes H, Robertson J, Klungland A, Enserink JM. TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity.Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1039-1044.

Olsen MB, Hildrestrand GA, Scheffler K, Vinge LE, Alfsnes K, Palibrk V, Wang J, Neurauter CG, Luna L, Johansen J, Øgaard JDS, Ohm IK, Slupphaug G, Kuśnierczyk A, Fiane AE, Brorson SH, Zhang L, Gullestad L, Louch WE, Iversen PO, Østlie I, Klungland A, Christensen G, Sjaastad I, Sætrom P, Yndestad A, Aukrust P, Bjørås M, Finsen AV.
NEIL3-Dependent
Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture. Cell Rep. 2017 Jan 3;18(1):82-92

Klungland A, Robertson AB. Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine. Free Radic Biol Med 2017 Jun;107:62-68.

Arjamaa O, Aaltonen V, Piippo N, Csont T, Petrovski G, Kaarniranta K, Kauppinen A (2017)
Hypoxia and inflammation in the release of VEGF and interleukins from human retinal pigment epithelial cells. Graefes Arch Clin Exp Ophthalmol, 255 (9), 1757-1762  PubMed 28631245 WOS 000407587600010 Cristin 1501797 FullText (Details)

Glatz W, Steinwender G, Tarmann L, Malle EM, Schörkhuber M, Wackernagel W, Petrovski G, Wedrich A, Ivastinovic D (2017) Vitreous hyper-reflective dots in pseudophakic cystoid macular edema assessed with optical coherence tomography. PLoS One, 12 (12), e0189194  PubMed 29244855 WOS 000418184700020 FullText (Details)

Hongisto H, Jylhä A, Nättinen J, Rieck J, Ilmarinen T, Veréb Z, Aapola U, Beuerman R, Petrovski G, Uusitalo H, Skottman H (2017) Comparative proteomic analysis of human embryonic stem cell-derived and primary human retinal pigment epithelium. Sci Rep, 7 (1), 6016 PubMed 28729539 WOS 000405907800070 Cristin 1503863 FullText (Details)

Hytti M, Andjelic S, Josifovska N, Piippo N, Korhonen E, Hawlina M, Kaarniranta K, Nevalainen TJ, Petrovski G, Parkkari T, Kauppinen A (2017)  CB2 receptor activation causes an ERK1/2-dependent inflammatory response in human RPE cells. Sci Rep, 7 (1), 16169 PubMed 29170454 WOS 000416129500004 Cristin 1528818 FullText (Details)

Hytti M, Szabó D, Piippo N, Korhonen E, Honkakoski P, Kaarniranta K, Petrovski G, Kauppinen A (2017) Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cells. J Nutr Biochem, 42, 37-42
PubMed 28113103 WOS 000398010600005 Cristin 1473840 FullText (Details)

Johnsen EO, Frøen RC, Olstad OK, Nicolaissen B, Petrovski G, Moe MC, Noer A (2017)
Proliferative Cells Isolated from the Adult Human Peripheral Retina only Transiently Upregulate Key Retinal Markers upon Induced Differentiation. Curr Eye Res, 1-10 (in press)  PubMed 29161152 FullText (Details)

Josifovska N, Szabó DJ, Nagymihály R, Veréb Z, Facskó A, Eriksen K, Moe MC, Petrovski G (2017) Cultivation and characterization of pterygium as an ex vivo study model for disease and therapy. Cont Lens Anterior Eye, 40 (5), 283-292
PubMed 28550976 WOS 000410658600003 FullText (Details)

Jørstad ØK, Faber RT, Moe MC (2017) Two-year functional and anatomical results after converting treatment resistant eyes with exudative age-related macular degeneration to aflibercept in accordance with a treat and extend protocol. Acta Ophthalmol, 95 (5), 460-463  PubMed 28556485 WOS 000405388500022 Cristin 1501447 FullText (Details)

Kaarniranta K, Petrovski G, Kauppinen A (2017)
The Nobel Prized cellular target autophagy in eye diseases. Acta Ophthalmol, 95 (4), 335-336
PubMed 28603953 WOS 000403361300013 FullText (Details)

Lytvynchuk L, Sergienko A, Savytska I, Albert R, Glittenberg C, Binder S, Petrovski G (2017)  Comparative cyto-histological study of needle tip aspirates and entry sites after intravitreal injection using different needle types. PLoS One, 12 (7), e0174467
PubMed 28692684 WOS 000405544800001 Cristin 1503675 FullText (Details)

Márkus B, Pató Z, Sarang Z, Albert R, Tőzsér J, Petrovski G, Csősz É (2017) The proteomic profile of a mouse model of proliferative vitreoretinopathy. FEBS Open Bio, 7 (8), 1166-1177  PubMed 28781956 WOS 000406682900010 Cristin 1501500 FullText (Details)

Nagymihály R, Veréb Z, Albert R, Sidney L, Dua H, Hopkinson A, Petrovski G (2017)
Cultivation and characterisation of the surface markers and carbohydrate profile of human corneal endothelial cells. Clin Exp Ophthalmol, 45 (5), 509-519  PubMed 28032398 WOS 000406911300011 FullText (Details)

Nagymihály R, Veréb Z, Facskó A, Moe MC, Petrovski G (2017) Effect of Isolation Technique and Location on the Phenotype of Human Corneal Stroma-Derived Cells. Stem Cells Int, 2017, 9275248 PubMed 29213290 WOS 000413828600001 FullText (Details)

Ness C, Garred Ø, Eide NA, Kumar T, Olstad OK, Bærland TP, Petrovski G, Moe MC, Noer A (2017) Multicellular tumor spheroids of human uveal melanoma induce genes associated with anoikis resistance, lipogenesis, and SSXs Mol Vis, 23, 680-694
PubMed 29033534 WOS 000412367800001 FullText (Details)

Petrovski G, Kaarniranta K, Petrovič D (2017) Oxidative Stress, Epigenetics, Environment, and Epidemiology of Diabetic Retinopathy. J Diabetes Res, 2017, 6419357  PubMed 28321416 WOS 000396146600001 FullText (Details)

Szabó DJ, Nagymihály R, Veréb Z, Josifovska N, Noer A, Liskova P, Facskó A, Moe MC, Petrovski G (2017) Ex vivo 3D human corneal stroma model for Schnyder corneal dystrophy - role of autophagy in its pathogenesis and resolution. Histol Histopathol, 11928 (in press)
PubMed 28872183 FullText (Details)

Siller R and Sullivan GJ*. Simple and rapid screen for human pluripotent stem cell endoderm differentiation potential. Current Protocols in Stem Cell Biology, 43, 1G.7.1–1G.7.23.doi: 10.1002/cpsc.36. (*corresponding author).

Rutkovskiy A, Malashicheva A, Sullivan GJ*, Bogdanova M, Kostareva A, Stensløkken KO, Fianne A, Vaage J. Valve Interstitial Cells: The Key to Understanding the Pathophysiology of Heart Valve Calcification. Journal of the American Heart Association. 2017: 14;6(9) pii: e006339. doi: 10.1161/JAHA.117.006339.(*co-corresponding author).

Scarfe L, Brillant N, Kumar JD, Ali N, Alrumayh A, Amali M, Barbellion S, Jones V, Niemeijer M, Potdevin S, Roussignol G, Vaganov A, Barbaric I, Barrow M, Burton NC, Connell J, Dazzi F, Edsbagge J, French NS, Holder J, Hutchinson C, Jones DR, Kalber T, Lovatt C, Lythgoe MF, Patel S, Patrick PS, Piner J, Reinhardt J, Ricci E, Sidaway J, Stacey GN, Starkey Lewis PJ, Sullivan G, Taylor A, Wilm B, Poptani H, Murray P, Goldring CEP, Park BK. Pre-clinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies. Nature Regenerative Medicine. 2017: (2017)2:28; doi:10.1038/s41536-017-0029-9.

Siller R, Greenhough S, Mathipati S, Si-Tayeb K* and Sullivan GJ*. Future challenges in the generation of hepatocyte like cells from human pluripotent stem cells. Current Pathobiology Reports. 2017:5:(3):301-314. (*co-corresponding author).

Siller R, Dufour E, Wilmut I, Jung Y-W, Park IH and Sullivan GJ*. Development of an inducible platform for intercellular protein delivery. International Journal of Pharmaceutics. 2017: http://dx.doi.org/10.1016/j.ijpharm.2017.02.067. (*corresponding author).

Gamal W, Treskes P, Chesne CG, Samuel K, Sullivan GJ, Siller R, Srsen V, Underwood I, Smith S, Hayes PC, Plevris JN, Bagnaninchi PO and Nelson LJ. Low-dose acetaminophen induces early disruption of cell-cell tight junctions in human hepatic cells and mouse liver. Scientific Reports. 2017:DOI: 10.1038/srep37541.

Klungland A, Dahl JA, Greggains G, Fedorcsak P, Filipczyk A.
Reversible RNA modifications in meiosis and pluripotency. 18 |VOL.14 NO.1 | Jan 2017 | NATURE METHODS

Thomas Fleischer, Xavier Tekpli, Anthony Mathelier, Shixiong Wang, Daniel Nebdal, Hari P. Dhakal, Kristine Kleivi Sahlberg, Ellen Schlichting, Oslo Breast Cancer Research Consortium (OSBREAC), Anne-Lise Børresen-Dale, Elin Borgen, Bjørn Naume,

Ragnhild Eskeland, Arnoldo Frigessi, Jörg Tost, Antoni Hurtado, Vessela N. Kristensen.
Major gene regulatory networks explained by DNA methylation at enhancers distinguish ER positive and ER negative breast cancer lineages. Nature Communications. 2017 Nov 9;8(1):1379. doi: 10.1038/s41467-017-00510-x.

Boris Simovski; Daniel Vodák; Sveinung Sveinung; Diana Domanska; Abdulrahman Azab; Lars Holden; Marit Holden; Ivar Grytten; Knut Dagestad Rand; Finn Drabløs; Morten Johansen; Antonio Mora; Christin Lund-Andersen; Bastian Fromm; Ragnhild Eskeland; Odd Stokke Gabrielsen; Sigve Nakken; Mads Bengtsen; Alexander Johan Nederbragt; Hildur Sif Thorarensen; Johannes Andreas Akse; Ingrid Glad; Eivind Hovig; Geir Kjetil Sandve.
GSuite HyperBrowser: integrative analysis of dataset collections across the genome and epigenome. GigaScience. 2017 Apr 27. doi: 10.1093/gigascience/gix032.

Bettina Maria Fuglerud, Roza Berhanu Lemma, Pimthanya Wanichawan, Arvind Sundaram, Marit Ledsaak, Ragnhild Eskeland and Odd Stokke Gabrielsen
The interaction of c-Myb with histone tails is disrupted by the hematopoietic mutant D152V - evidence for altered pioneer function. Nucleic Acids Research. Nucleic Acids Res. 2017 May 2. doi: 10.1093/nar/gkx364. [Epub ahead of print]

Marie MacLennan, Marta García-Cañadas, Judith Reichmann, Elena Khazina, Carmen Salvador-Palomeque, Abigail R. Mann, Paula Peressini, Laura Sanchez, Christopher J. Playfoot, David Read, Chao-Chun Hung, Ragnhild Eskeland, Richard R. Meehan, Oliver Weichenrieder, Jose Luis García-Pérez, Ian R. Adams.
The Ubiquitin-Proteasome System Protects The Mammalian Germline From L1 Retrotransposons. eLife 2017 Aug 14;6. pii: e26152. doi: 10.7554/eLife.26152.

Abadpour S, Gopel SO, Schive SW, Korsgren O, Foss A, Scholz H.
Glial cell-line derived neurotrophic factor protects human islets from nutrient deprivation and endoplasmic reticulum stress induced apoptosis. Sci Rep. 2017;7(1):1575.

Hals I, Ohki T, Singh R, Ma Z, Björklund A, Balasuriya C, Scholz H, Grill V.Hyperoxia reduces insulin release and induces mitochondrial dysfunction with possible implications for hyperoxic treatment of neonates. Physiol Rep. 2017;5(19).

Li X, Zhong Y, Lu J, Axcrona K, Eide L, Syljuåsen RG, Peng Q, Wang J, Zhang H, Goscinski MA, Kvalheim G, Nesland JM, Suo Z. Correction: MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features.
Oncotarget. 2017 Jan 24;8(4):7208-7213. doi: 10.18632/oncotarget.14800. No abstract available.

Wang MY, Nestvold J, Rekdal Ø, Kvalheim G, Fodstad Ø. A novel rat fibrosarcoma cell line from transformed bone marrow-derived mesenchymal stem cells with maintained in vitro and in vivo stemness properties. Exp Cell Res. 2017 Mar 15;352(2):218-224. doi: 10.1016/j.yexcr.2017.02.005. Epub 2017 Feb 9.

Inderberg EM, Wälchli S, Myhre MR, Trachsel S, Almåsbak H, Kvalheim G, Gaudernack G.
T cell therapy targeting a public neoantigen in microsatellite instable colon cancer reduces in vivo tumor growth.
Oncoimmunology. 2017 Mar 17;6(4):e1302631. doi: 10.1080/2162402X.2017.1302631. eCollection 2017.

Li X, Lu J, Kan Q, Li X, Fan Q, Li Y, Huang R, Slipicevic A, Dong HP, Eide L, Wang J, Zhang H, Berge V, Goscinski MA, Kvalheim G, Nesland JM, Suo Z. Metabolic reprogramming is associated with flavopiridol resistance in prostate cancer DU145 cells. Sci Rep. 2017 Jul 11;7(1):5081. doi: 10.1038/s41598-017-05086-6.

Li X, Grigalavicius M, Li Y, Li X, Zhong Y, Huang R, Yu D, Berge V, Goscinski MA, Kvalheim G, Nesland JM, Suo Z.
MtDNA depletion influences the transition of CD44 subtypes in human prostate cancer DU145 cells. Tumour Biol. 2017 Aug;39(8):1010428317713671. doi: 10.1177/1010428317713671.

Walseng E, Köksal H, Sektioglu IM, Fåne A, Skorstad G, Kvalheim G, Gaudernack G, Inderberg EM, Wälchli S.
A TCR-based Chimeric Antigen Receptor. Sci Rep. 2017 Sep 6;7(1):10713. doi: 10.1038/s41598-017-11126-y.

Nestvold J, Wang MY, Camilio KA, Zinöcker S, Tjelle TE, Lindberg A, Haug BE, Kvalheim G, Sveinbjørnsson B, Rekdal Ø. Oncolytic peptide LTX-315 induces an immune-mediated abscopal effect in a rat sarcoma model. Oncoimmunology. 2017 Jun 16;6(8):e1338236. doi: 10.1080/2162402X.2017.1338236. eCollection 2017.

Eide N, Faye RS, Høifødt HK, Sandvik L, Qvale GA, Faber R, Jebsen P, Kvalheim G, Fodstad Ø. The Results of Stricter Inclusion Criteria in an Immunomagnetic Detection Study of Micrometastatic Cells in Bone Marrow of Uveal Melanoma Patients - Relevance for Dormancy. Pathol Oncol Res. 2017 Nov 2. doi: 10.1007/s12253-017-0355-7.

Inderberg EM, Mensali N, Oksvold MP, Fallang LE, Fåne A, Skorstad G, Stenvik GE, Progida C, Bakke O, Kvalheim G, Myklebust JH, Wälchli S. Human c-SRC kinase (CSK) overexpression makes T cells dummy. Cancer Immunol Immunother. 2017 Dec 16. doi: 10.1007/s00262-017-2105-9. [Epub ahead of print]

Schive SW, Foss A, Sahraoui A, Kloster-Jensen K, Hafsahl G, Kvalheim G, Lundgren T, von Zur-Mühlen B, Felldin M, Rafael E, Lempinen M, Korsgren O, Jenssen TG, Mishra V, Scholz H.
Cost and clinical outcome of islet transplantation in Norway 2010-2015. Clin Transplant. 2017;31(1).

Schive SW, Mirlashari MR, Hasvold G, Wang M, Josefsen D, Gullestad HP, Korsgren O, Foss A, Kvalheim G, Scholz H. Human Adipose-Derived Mesenchymal Stem Cells Respond to Short-Term Hypoxia by Secreting Factors Beneficial for Human Islets In Vitro and Potentiate Antidiabetic Effect In Vivo. Cell Med. 2017;9(3):103-16.

Schuetz C, Anazawa T, Cross SE, Labriola L, Meier RPH, Redfield RR 3rd, Scholz H, Stock PG, Zammit NW; IPITA YIC Young Investigator Committee. ss cell replacement therapy: the next 10 years. Transplantation. 2017.

Vethe H, Bjorlykke Y, Ghila LM, Paulo JA, Scholz H, Gygi SP, et al. Probing the missing mature beta-cell proteomic landscape in differentiating patient iPSC-derived cells. Sci Rep. 2017;7(1):4780.

 

 

Rydning SL, Backe PH, Sousa MML, Iqbal Z, Øye AM, Sheng Y, Yang M, Lin X, Slupphaug G, Nordenmark TH, Vigeland MD, Bjørås M, Tallaksen CM, Selmer KK.
Novel UCHL1 mutations reveal new insights into ubiquitin processing. Hum Mol Genet. 2017 Mar 15;26(6):1217-1218

Morland C, Andersson KA, Haugen ØP, Hadzic A, Kleppa L, Gille A, Rinholm JE, Palibrk V, Diget EH, Kennedy LH, Stølen T, Hennestad E, Moldestad O, Cai Y, Puchades M, Offermanns S, Vervaeke K, Bjørås M, Wisløff U, Storm-Mathisen J, Bergersen LH.
Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1. Nat Commun. 2017 May 23;8:15557

Bosshard M, Aprigliano R, Gattiker C, Palibrk V, Markkanen E, Hoff Backe P, Pellegrino S, Raymond FL, Froyen G, Altmeyer M, Bjørås M, Dianov GL, van Loon B.
Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability. Sci Rep. 2017 Nov 8;7(1):15050

Kosik-Kozioł A, Costantini M, Bolek T, Szöke K, Barbetta A, Brinchmann JE, Święszkowski W.
PLA short sub-micron fiber reinforcement of 3D bioprinted alginate constructs for cartilage regeneration. Biofabrication. 2017 Nov 14;9(4):044105. doi: 10.1088/1758-5090/aa90d7

 Szöke K, Danakova J, Bugzo M, Amler E, Brinchmann JE, Østrup E.
The effect of medium composition on deposition of collagen type I and expression of osteogenic genes in mesenchymal stem cells derived from human adipose tissue and bone marrow. Proc Biochem 2017;59,321-28.

Wollert KC, Meyer GP, Müller-Ehmsen J, Tschöpe C, Bonarjee V, Larsen AI, May AE, Empen K, Chorianopoulos E, Tebbe U, Waltenberger J, Mahrholdt H, Ritter B, Pirr J, Fischer D, Korf-Klingebiel M, Arseniev L, Heuft HG, Brinchmann JE, Messinger D, Hertenstein B, Ganser A, Katus HA, Felix SB, Gawaz MP, Dickstein K, Schultheiss HP, Ladage D, Greulich S, Bauersachs J.Eur Heart J. Intracoronary autologous bone marrow cell transfer after myocardial infarction: the BOOST-2 randomised placebo-controlled clinical trial. 2017 Oct 14;38(39):2936-2943. doi: 10.1093/eurheartj/ehx188

Behnan J, Stangeland B, Hosainey SAM, Joel M, Olsen TK, Micci F, Glover JC, Isakson P, Brinchmann JE. Differential propagation of stroma and cancer stem cells dictates tumorigenesis and multipotency. Oncogene. 2017 Jan 26;36(4):570-584

 Karlsen TA, Jakobsen RB, Brinchmann JE. Early molecular events during in vitro chondrogenesis. In The Biology and Therapeutic Application of Mesenchymal Cells (ed K. Atkinson), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118907474.ch14

 Paulsen J, Sekelja M, Oldenburg AR, Barateau A, Briand N, Delbarre E, Shah, A, Sørensen AL, Vigouroux C, Buendia B, Collas P. 2017. Chrom3D: three-dimensional genome modeling from Hi-C and nuclear lamin-genome contacts. Genome Biol. 18, 21-29

 Guénantin AC, Briand N, Capel E, Dumont F, Morichon R, Provost C, Stillitano F, Jeziorowska D, Siffroi JP, Hajjar RJ, Fève B, Hulot JS, Collas P, Capeau J, Vigouroux C. 2017. Functional human beige adipocytes from induced pluripotent stem cells. Diabetes 66, 1470-1478

Delbarre, E, Ivanauskiene K, Spirkoski J, Shah A, Vekterud K, Moskaug JØ, Bøe SO, Wong L, Küntziger T, Collas P. 2017. PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX. Genome Res. 27, 913-921

López-Soop G, Rønningen T, Rogala A, Richartz N, Blomhoff HK, Thiede B, Collas P, Küntziger T. 2017. AKAP95 interacts with nucleoporin TPR in mitosis and is important for the spindle assembly checkpoint. Cell Cycle 16, 947-956

Oldenburg AR, Briand N, Sørensen AL, Cahyani I, Shah A, Moskaug JØ, Collas P 2017. A lipodystrophy-causing lamin A mutant alters conformation and epigenetic regulation of the anti-adipogenic MIR335 locus. J Cell Biol. 216, 2731-2743

Garcia-Nieto PE, Schwartz E, King DA, Paulsen J, Collas P, Herrera RE, Morrison AJ. 2017.
Carcinogen susceptibility is regulated by genome architecture and dictates cancer mutagenenesis. EMBO J. 36, 2839-2843

Meier M, Grant J, Dowdle A, Thomas A, Gerton J, Collas P, O'Sullivan JM, Horsfield JA. 2017.
Cohesin facilitates zygotic genome activation in zebrafish. Development. doi: 10.1242/dev.156521

Züchner M, Kondratskaya E, Sylte CB, Glover JC, Boulland JL. Rapid recovery and altered neurochemical dependence of locomotor central pattern generation following lumbar neonatal spinal cord injury. J Physiol. 2018 Jan 15;596(2):281-303. doi: 10.1113/JP274484. Epub 2017 Dec 3.

Chagnaud BP, Engelmann J, Fritzsch B, Glover JC, Straka H. Sensing External and Self-Motion with Hair Cells: A Comparison of the Lateral Line and Vestibular Systems from a Developmental and Evolutionary Perspective.Brain Behav Evol. 2017;90(2):98-116. doi: 10.1159/000456646. Epub 2017 Oct 9.

Fritzsch B, Elliott KL, Glover JC. Gaskell revisited: new insights into spinal autonomics necessitate a revised motor neuron nomenclature. Cell Tissue Res. 2017 Nov;370(2):195-209. doi: 10.1007/s00441-017-2676-y. Epub 2017 Aug 31. Review.

Chawla RS, Züchner M, Mastrangelopoulou M, Lambert FM, Glover JC, Boulland JL.
Cellular reactions and compensatory tissue re-organization during spontaneous recovery after spinal cord injury in neonatal mice. Dev Neurobiol. 2017 Sep;77(8):928-946. doi: 10.1002/dneu.22479. Epub 2017 Feb 17.

Tang C, Klukovich R, Peng H, Wang Z, Yu T, Zhang Y, Zheng H, Klungland A, Yan W. ALKBH5-dependent m6A demethylation controls splicing and stability of long 3'-UTR mRNAs in male germ cells. Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E325-E333

Pawar T, Bjørås M, Klungland A, Eide L. Metabolism and DNA repair shape a specific modification pattern in mitochondrial DNA. Mitochondrion. 2017 Sep 8. pii: S1567-7249(17)30208-8

Seifermann M, Ulges A, Bopp T, Melcea S, Schäfer A, Oka S, Nakabeppu Y, Klungland A, Niehrs C, Epe B.
Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes. DNA Repair (Amst). 2017 Oct;58:13-20.

Jordan JJ, Chhim S, Margulies CM, Allocca M, Bronson RT, Klungland A, Samson LD, Fu D. ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage. Cell Death Dis. 2017 Jul 20;8(7):e2947.

Rolseth V, Luna L, Olsen AK, Suganthan R, Scheffler K, Neurauter CG, Esbensen Y, Kuśnierczyk A, Hildrestrand GA, Graupner A, Andersen JM, Slupphaug G, Klungland A, Nilsen H, Bjørås M. No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice. Sci Rep. 2017 Jun 29;7(1):4384

Landfors M, Johansen J, Aronsen JM, Vågbø CB, Doré LC, He C, Sjaastad I, Sætrom P, Fedorcsák P, Dahl JA, Aanes H, Fußer M, Klungland A.
Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation. Cell Discov. 2017 May 9;3:17013.

Aas A, Isakson P, Bindesbøll C, Alemu EA, Klungland A, Simonsen A.
Nucleocytoplasmic Shuttling of FTO Does Not Affect Starvation-Induced Autophagy. PLoS One. 2017 Mar 13;12(3):e0168182.

Kalikstad B, Kultima HG, Andersstuen TK, Klungland A, Isaksson A. Gene expression profiles on preterm infants on continuous long‑term oxygen therapy suggest reduced oxidative stress‑dependent signaling during hypoxia. Mol Med Rep. 2017 Apr;15(4):1513-1526

Chymkowitch P, Nguéa P A, Aanes H, Robertson J, Klungland A, Enserink JM. TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity.Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1039-1044.

Olsen MB, Hildrestrand GA, Scheffler K, Vinge LE, Alfsnes K, Palibrk V, Wang J, Neurauter CG, Luna L, Johansen J, Øgaard JDS, Ohm IK, Slupphaug G, Kuśnierczyk A, Fiane AE, Brorson SH, Zhang L, Gullestad L, Louch WE, Iversen PO, Østlie I, Klungland A, Christensen G, Sjaastad I, Sætrom P, Yndestad A, Aukrust P, Bjørås M, Finsen AV.
NEIL3-Dependent
Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture. Cell Rep. 2017 Jan 3;18(1):82-92

Klungland A, Robertson AB. Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine. Free Radic Biol Med 2017 Jun;107:62-68.

Arjamaa O, Aaltonen V, Piippo N, Csont T, Petrovski G, Kaarniranta K, Kauppinen A (2017)
Hypoxia and inflammation in the release of VEGF and interleukins from human retinal pigment epithelial cells. Graefes Arch Clin Exp Ophthalmol, 255 (9), 1757-1762  PubMed 28631245 WOS 000407587600010 Cristin 1501797 FullText (Details)

Glatz W, Steinwender G, Tarmann L, Malle EM, Schörkhuber M, Wackernagel W, Petrovski G, Wedrich A, Ivastinovic D (2017) Vitreous hyper-reflective dots in pseudophakic cystoid macular edema assessed with optical coherence tomography. PLoS One, 12 (12), e0189194  PubMed 29244855 WOS 000418184700020 FullText (Details)

Hongisto H, Jylhä A, Nättinen J, Rieck J, Ilmarinen T, Veréb Z, Aapola U, Beuerman R, Petrovski G, Uusitalo H, Skottman H (2017) Comparative proteomic analysis of human embryonic stem cell-derived and primary human retinal pigment epithelium. Sci Rep, 7 (1), 6016 PubMed 28729539 WOS 000405907800070 Cristin 1503863 FullText (Details)

Hytti M, Andjelic S, Josifovska N, Piippo N, Korhonen E, Hawlina M, Kaarniranta K, Nevalainen TJ, Petrovski G, Parkkari T, Kauppinen A (2017)  CB2 receptor activation causes an ERK1/2-dependent inflammatory response in human RPE cells. Sci Rep, 7 (1), 16169 PubMed 29170454 WOS 000416129500004 Cristin 1528818 FullText (Details)

Hytti M, Szabó D, Piippo N, Korhonen E, Honkakoski P, Kaarniranta K, Petrovski G, Kauppinen A (2017) Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cells. J Nutr Biochem, 42, 37-42
PubMed 28113103 WOS 000398010600005 Cristin 1473840 FullText (Details)

Johnsen EO, Frøen RC, Olstad OK, Nicolaissen B, Petrovski G, Moe MC, Noer A (2017)
Proliferative Cells Isolated from the Adult Human Peripheral Retina only Transiently Upregulate Key Retinal Markers upon Induced Differentiation. Curr Eye Res, 1-10 (in press)  PubMed 29161152 FullText (Details)

Josifovska N, Szabó DJ, Nagymihály R, Veréb Z, Facskó A, Eriksen K, Moe MC, Petrovski G (2017) Cultivation and characterization of pterygium as an ex vivo study model for disease and therapy. Cont Lens Anterior Eye, 40 (5), 283-292
PubMed 28550976 WOS 000410658600003 FullText (Details)

Jørstad ØK, Faber RT, Moe MC (2017) Two-year functional and anatomical results after converting treatment resistant eyes with exudative age-related macular degeneration to aflibercept in accordance with a treat and extend protocol. Acta Ophthalmol, 95 (5), 460-463  PubMed 28556485 WOS 000405388500022 Cristin 1501447 FullText (Details)

Kaarniranta K, Petrovski G, Kauppinen A (2017)
The Nobel Prized cellular target autophagy in eye diseases. Acta Ophthalmol, 95 (4), 335-336
PubMed 28603953 WOS 000403361300013 FullText (Details)

Lytvynchuk L, Sergienko A, Savytska I, Albert R, Glittenberg C, Binder S, Petrovski G (2017)  Comparative cyto-histological study of needle tip aspirates and entry sites after intravitreal injection using different needle types. PLoS One, 12 (7), e0174467
PubMed 28692684 WOS 000405544800001 Cristin 1503675 FullText (Details)

Márkus B, Pató Z, Sarang Z, Albert R, Tőzsér J, Petrovski G, Csősz É (2017) The proteomic profile of a mouse model of proliferative vitreoretinopathy. FEBS Open Bio, 7 (8), 1166-1177  PubMed 28781956 WOS 000406682900010 Cristin 1501500 FullText (Details)

Nagymihály R, Veréb Z, Albert R, Sidney L, Dua H, Hopkinson A, Petrovski G (2017)
Cultivation and characterisation of the surface markers and carbohydrate profile of human corneal endothelial cells. Clin Exp Ophthalmol, 45 (5), 509-519  PubMed 28032398 WOS 000406911300011 FullText (Details)

Nagymihály R, Veréb Z, Facskó A, Moe MC, Petrovski G (2017) Effect of Isolation Technique and Location on the Phenotype of Human Corneal Stroma-Derived Cells. Stem Cells Int, 2017, 9275248 PubMed 29213290 WOS 000413828600001 FullText (Details)

Ness C, Garred Ø, Eide NA, Kumar T, Olstad OK, Bærland TP, Petrovski G, Moe MC, Noer A (2017) Multicellular tumor spheroids of human uveal melanoma induce genes associated with anoikis resistance, lipogenesis, and SSXs Mol Vis, 23, 680-694
PubMed 29033534 WOS 000412367800001 FullText (Details)

Petrovski G, Kaarniranta K, Petrovič D (2017) Oxidative Stress, Epigenetics, Environment, and Epidemiology of Diabetic Retinopathy. J Diabetes Res, 2017, 6419357  PubMed 28321416 WOS 000396146600001 FullText (Details)

Szabó DJ, Nagymihály R, Veréb Z, Josifovska N, Noer A, Liskova P, Facskó A, Moe MC, Petrovski G (2017) Ex vivo 3D human corneal stroma model for Schnyder corneal dystrophy - role of autophagy in its pathogenesis and resolution. Histol Histopathol, 11928 (in press)
PubMed 28872183 FullText (Details)

Siller R and Sullivan GJ*. Simple and rapid screen for human pluripotent stem cell endoderm differentiation potential. Current Protocols in Stem Cell Biology, 43, 1G.7.1–1G.7.23.doi: 10.1002/cpsc.36. (*corresponding author).

Rutkovskiy A, Malashicheva A, Sullivan GJ*, Bogdanova M, Kostareva A, Stensløkken KO, Fianne A, Vaage J. Valve Interstitial Cells: The Key to Understanding the Pathophysiology of Heart Valve Calcification. Journal of the American Heart Association. 2017: 14;6(9) pii: e006339. doi: 10.1161/JAHA.117.006339.(*co-corresponding author).

Scarfe L, Brillant N, Kumar JD, Ali N, Alrumayh A, Amali M, Barbellion S, Jones V, Niemeijer M, Potdevin S, Roussignol G, Vaganov A, Barbaric I, Barrow M, Burton NC, Connell J, Dazzi F, Edsbagge J, French NS, Holder J, Hutchinson C, Jones DR, Kalber T, Lovatt C, Lythgoe MF, Patel S, Patrick PS, Piner J, Reinhardt J, Ricci E, Sidaway J, Stacey GN, Starkey Lewis PJ, Sullivan G, Taylor A, Wilm B, Poptani H, Murray P, Goldring CEP, Park BK. Pre-clinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies. Nature Regenerative Medicine. 2017: (2017)2:28; doi:10.1038/s41536-017-0029-9.

Siller R, Greenhough S, Mathipati S, Si-Tayeb K* and Sullivan GJ*. Future challenges in the generation of hepatocyte like cells from human pluripotent stem cells. Current Pathobiology Reports. 2017:5:(3):301-314. (*co-corresponding author).

Siller R, Dufour E, Wilmut I, Jung Y-W, Park IH and Sullivan GJ*. Development of an inducible platform for intercellular protein delivery. International Journal of Pharmaceutics. 2017: http://dx.doi.org/10.1016/j.ijpharm.2017.02.067. (*corresponding author).

Gamal W, Treskes P, Chesne CG, Samuel K, Sullivan GJ, Siller R, Srsen V, Underwood I, Smith S, Hayes PC, Plevris JN, Bagnaninchi PO and Nelson LJ. Low-dose acetaminophen induces early disruption of cell-cell tight junctions in human hepatic cells and mouse liver. Scientific Reports. 2017:DOI: 10.1038/srep37541.

Klungland A, Dahl JA, Greggains G, Fedorcsak P, Filipczyk A.
Reversible RNA modifications in meiosis and pluripotency. 18 |VOL.14 NO.1 | Jan 2017 | NATURE METHODS

Thomas Fleischer, Xavier Tekpli, Anthony Mathelier, Shixiong Wang, Daniel Nebdal, Hari P. Dhakal, Kristine Kleivi Sahlberg, Ellen Schlichting, Oslo Breast Cancer Research Consortium (OSBREAC), Anne-Lise Børresen-Dale, Elin Borgen, Bjørn Naume,

Ragnhild Eskeland, Arnoldo Frigessi, Jörg Tost, Antoni Hurtado, Vessela N. Kristensen.
Major gene regulatory networks explained by DNA methylation at enhancers distinguish ER positive and ER negative breast cancer lineages. Nature Communications. 2017 Nov 9;8(1):1379. doi: 10.1038/s41467-017-00510-x.

Boris Simovski; Daniel Vodák; Sveinung Sveinung; Diana Domanska; Abdulrahman Azab; Lars Holden; Marit Holden; Ivar Grytten; Knut Dagestad Rand; Finn Drabløs; Morten Johansen; Antonio Mora; Christin Lund-Andersen; Bastian Fromm; Ragnhild Eskeland; Odd Stokke Gabrielsen; Sigve Nakken; Mads Bengtsen; Alexander Johan Nederbragt; Hildur Sif Thorarensen; Johannes Andreas Akse; Ingrid Glad; Eivind Hovig; Geir Kjetil Sandve.
GSuite HyperBrowser: integrative analysis of dataset collections across the genome and epigenome. GigaScience. 2017 Apr 27. doi: 10.1093/gigascience/gix032.

Bettina Maria Fuglerud, Roza Berhanu Lemma, Pimthanya Wanichawan, Arvind Sundaram, Marit Ledsaak, Ragnhild Eskeland and Odd Stokke Gabrielsen
The interaction of c-Myb with histone tails is disrupted by the hematopoietic mutant D152V - evidence for altered pioneer function. Nucleic Acids Research. Nucleic Acids Res. 2017 May 2. doi: 10.1093/nar/gkx364. [Epub ahead of print]

Marie MacLennan, Marta García-Cañadas, Judith Reichmann, Elena Khazina, Carmen Salvador-Palomeque, Abigail R. Mann, Paula Peressini, Laura Sanchez, Christopher J. Playfoot, David Read, Chao-Chun Hung, Ragnhild Eskeland, Richard R. Meehan, Oliver Weichenrieder, Jose Luis García-Pérez, Ian R. Adams.
The Ubiquitin-Proteasome System Protects The Mammalian Germline From L1 Retrotransposons. eLife 2017 Aug 14;6. pii: e26152. doi: 10.7554/eLife.26152.

Abadpour S, Gopel SO, Schive SW, Korsgren O, Foss A, Scholz H.
Glial cell-line derived neurotrophic factor protects human islets from nutrient deprivation and endoplasmic reticulum stress induced apoptosis. Sci Rep. 2017;7(1):1575.

Hals I, Ohki T, Singh R, Ma Z, Björklund A, Balasuriya C, Scholz H, Grill V.Hyperoxia reduces insulin release and induces mitochondrial dysfunction with possible implications for hyperoxic treatment of neonates. Physiol Rep. 2017;5(19).

Li X, Zhong Y, Lu J, Axcrona K, Eide L, Syljuåsen RG, Peng Q, Wang J, Zhang H, Goscinski MA, Kvalheim G, Nesland JM, Suo Z. Correction: MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features.
Oncotarget. 2017 Jan 24;8(4):7208-7213. doi: 10.18632/oncotarget.14800. No abstract available.

Wang MY, Nestvold J, Rekdal Ø, Kvalheim G, Fodstad Ø. A novel rat fibrosarcoma cell line from transformed bone marrow-derived mesenchymal stem cells with maintained in vitro and in vivo stemness properties. Exp Cell Res. 2017 Mar 15;352(2):218-224. doi: 10.1016/j.yexcr.2017.02.005. Epub 2017 Feb 9.

Inderberg EM, Wälchli S, Myhre MR, Trachsel S, Almåsbak H, Kvalheim G, Gaudernack G.
T cell therapy targeting a public neoantigen in microsatellite instable colon cancer reduces in vivo tumor growth.
Oncoimmunology. 2017 Mar 17;6(4):e1302631. doi: 10.1080/2162402X.2017.1302631. eCollection 2017.

Li X, Lu J, Kan Q, Li X, Fan Q, Li Y, Huang R, Slipicevic A, Dong HP, Eide L, Wang J, Zhang H, Berge V, Goscinski MA, Kvalheim G, Nesland JM, Suo Z. Metabolic reprogramming is associated with flavopiridol resistance in prostate cancer DU145 cells. Sci Rep. 2017 Jul 11;7(1):5081. doi: 10.1038/s41598-017-05086-6.

Li X, Grigalavicius M, Li Y, Li X, Zhong Y, Huang R, Yu D, Berge V, Goscinski MA, Kvalheim G, Nesland JM, Suo Z.
MtDNA depletion influences the transition of CD44 subtypes in human prostate cancer DU145 cells. Tumour Biol. 2017 Aug;39(8):1010428317713671. doi: 10.1177/1010428317713671.

Walseng E, Köksal H, Sektioglu IM, Fåne A, Skorstad G, Kvalheim G, Gaudernack G, Inderberg EM, Wälchli S.
A TCR-based Chimeric Antigen Receptor. Sci Rep. 2017 Sep 6;7(1):10713. doi: 10.1038/s41598-017-11126-y.

Nestvold J, Wang MY, Camilio KA, Zinöcker S, Tjelle TE, Lindberg A, Haug BE, Kvalheim G, Sveinbjørnsson B, Rekdal Ø. Oncolytic peptide LTX-315 induces an immune-mediated abscopal effect in a rat sarcoma model. Oncoimmunology. 2017 Jun 16;6(8):e1338236. doi: 10.1080/2162402X.2017.1338236. eCollection 2017.

Eide N, Faye RS, Høifødt HK, Sandvik L, Qvale GA, Faber R, Jebsen P, Kvalheim G, Fodstad Ø. The Results of Stricter Inclusion Criteria in an Immunomagnetic Detection Study of Micrometastatic Cells in Bone Marrow of Uveal Melanoma Patients - Relevance for Dormancy. Pathol Oncol Res. 2017 Nov 2. doi: 10.1007/s12253-017-0355-7.

Inderberg EM, Mensali N, Oksvold MP, Fallang LE, Fåne A, Skorstad G, Stenvik GE, Progida C, Bakke O, Kvalheim G, Myklebust JH, Wälchli S. Human c-SRC kinase (CSK) overexpression makes T cells dummy. Cancer Immunol Immunother. 2017 Dec 16. doi: 10.1007/s00262-017-2105-9. [Epub ahead of print]

Schive SW, Foss A, Sahraoui A, Kloster-Jensen K, Hafsahl G, Kvalheim G, Lundgren T, von Zur-Mühlen B, Felldin M, Rafael E, Lempinen M, Korsgren O, Jenssen TG, Mishra V, Scholz H.
Cost and clinical outcome of islet transplantation in Norway 2010-2015. Clin Transplant. 2017;31(1).

Schive SW, Mirlashari MR, Hasvold G, Wang M, Josefsen D, Gullestad HP, Korsgren O, Foss A, Kvalheim G, Scholz H. Human Adipose-Derived Mesenchymal Stem Cells Respond to Short-Term Hypoxia by Secreting Factors Beneficial for Human Islets In Vitro and Potentiate Antidiabetic Effect In Vivo. Cell Med. 2017;9(3):103-16.

Schuetz C, Anazawa T, Cross SE, Labriola L, Meier RPH, Redfield RR 3rd, Scholz H, Stock PG, Zammit NW; IPITA YIC Young Investigator Committee. ss cell replacement therapy: the next 10 years. Transplantation. 2017.

Vethe H, Bjorlykke Y, Ghila LM, Paulo JA, Scholz H, Gygi SP, et al. Probing the missing mature beta-cell proteomic landscape in differentiating patient iPSC-derived cells. Sci Rep. 2017;7(1):4780.

 

 

 
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