OUH - Group members

Synne Brune-Ingebretsen

PhD student; MD

Synne Brune has a medical doctor degree from University of Oslo in 2013. She has been working at the neurologic departements at Bodø hospital and Oslo University Hospital for almost three years, and also at the neurosurgical department at Oslo University Hospital for 6 months.

Research Project:

Synne Brune started the project denoted «MRI changes and clinical MS phenotypes» in 2018. The overall objective for this Ph.D project is to identify novel MRI biomarkers of MS, which in the future will guide the clinician in follow-up and treatment of newly diagnosed patients.

Main supervisor: Hanne F. Harbo (Professor and consultant of neurology, Oslo University hospital).

Co-supervisor: Tone Berge

Co-supervisors: Pål Berg Hansen (Consultant of neurology, PhD, Oslo University hospital) and Mona Beyer (Professor at the Department of neuroradiology, Oslo University hospital).

Publications 2024

Kennedy KE, Kerlero de Rosbo N, Uccelli A, Cellerino M, Ivaldi F, Contini P, De Palma R, Harbo HF, Berge T, Bos SD, Høgestøl EA, Brune-Ingebretsen S, de Rodez Benavent SA, Paul F, Brandt AU, Bäcker-Koduah P, Behrens J, Kuchling J, Asseyer S, Scheel M, Chien C, Zimmermann H, Motamedi S, Kauer-Bonin J, Saez-Rodriguez J et al. (2024)
Multiscale networks in multiple sclerosis
PLoS Comput Biol, 20 (2), e1010980
DOI 10.1371/journal.pcbi.1010980, PubMed 38329927

Publications 2023

Brune-Ingebretsen S, Høgestøl EA, de Rosbo NK, Berg-Hansen P, Brunborg C, Blennow K, Zetterberg H, Paul F, Uccelli A, Villoslada P, Harbo HF, Berge T (2023)
Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis
J Neuroimmunol, 382, 578175
DOI 10.1016/j.jneuroim.2023.578175, PubMed 37573634

Publications 2022

Brune S, Høgestøl EA, de Rodez Benavent SA, Berg-Hansen P, Beyer MK, Leikfoss IS, Bos SD, Sowa P, Brunborg C, Andorra M, Pulido Valdeolivas I, Asseyer S, Brandt A, Chien C, Scheel M, Blennow K, Zetterberg H, Kerlero de Rosbo N, Paul F, Uccelli A, Villoslada P, Berge T, Harbo HF (2022)
Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis
Mult Scler, 28 (12), 1859-1870
DOI 10.1177/13524585221097296, PubMed 35658739

Rise HH, Brune S, Chien C, Berge T, Bos SD, Andorrà M, Valdeolivas IP, Beyer MK, Sowa P, Scheel M, Brandt AU, Asseyer S, Blennow K, Pedersen ML, Zetterberg H, de Schotten MT, Cellerino M, Uccelli A, Paul F, Villoslada P, Harbo HF, Westlye LT, Høgestøl EA (2022)
Brain disconnectome mapping derived from white matter lesions and serum neurofilament light levels in multiple sclerosis: A longitudinal multicenter study
Neuroimage Clin, 35, 103099
DOI 10.1016/j.nicl.2022.103099, PubMed 35772194

Solheim AM, Lorentzen ÅR, Dahlberg AO, Flemmen HØ, Brune S, Forselv KJN, Pripp AH, Bø MH, Eikeland R, Reiso H, Mygland Å, Ljøstad U (2022)
Six versus 2 weeks treatment with doxycycline in European Lyme neuroborreliosis: a multicentre, non-inferiority, double-blinded, randomised and placebo-controlled trial
J Neurol Neurosurg Psychiatry, 93 (11), 1222-8 (in press)
DOI 10.1136/jnnp-2022-329724, PubMed 35896378

Publications 2020

Brune S, Høgestøl EA, Cengija V, Berg-Hansen P, Sowa P, Nygaard GO, Harbo HF, Beyer MK (2020)
LesionQuant for Assessment of MRI in Multiple Sclerosis-A Promising Supplement to the Visual Scan Inspection
Front Neurol, 11, 546744
DOI 10.3389/fneur.2020.546744, PubMed 33362682