Steffan Daniƫl Bos

  • Postdoc; PhD
  • +47 230 79024

Bos has obtained a PhD degree in genetics after obtaining a Master degree in biopharmaceutics, University of Leiden, The Netherlands. His research has focused on the genetics of complex diseases and in particular the follow up of genes showing involvement through genome wide approaches.

Project/research interest:
Bos' main project encompasses the investigation of the epigenetic profile of MS patients' immune cells. Furthermore, the functional follow up of genes implicated in MS through recent genome wide approaches is a focus point in his research. Bos is co-supervisor for Pankaj Kumar Keshari.

Adress: Oslo University Hospital, Research Unit for Neuroscience, Domus Medica II, 2nd floor, L-268, Gaustadalleen 34, 0372 Oslo

 

Publications 2021

Eriksson AM, Leikfoss IS, Abrahamsen G, Sundvold V, Isom MM, Keshari PK, Rognes T, Landsverk OJB, Bos SD, Harbo HF, Spurkland A, Berge T (2021)
Exploring the role of the multiple sclerosis susceptibility gene CLEC16A in T cells
Scand. J. Immunol., 94 (1), e13050
DOI 10.1111/sji.13050

Publications 2020

Adams CJ, Wu SL, Shao XR, Bradshaw PT, Gonzales E, Smith JB, Xiang AH, Bellesis KH, Chinn T, Bos SD, Wendel-Haga M, Olsson T, Kockum I, Langer-Gould AM, Schaefer C, Alfredsson L, Barcellos LF (2020)
Pregnancy does not modify the risk of MS in genetically susceptible women
Neurol.-Neuroimmunol. Neuroinflammation, 7 (6), e898
DOI 10.1212/NXI.0000000000000898

Publications 2019

Berge T, Eriksson A, Brorson IS, Hogestol EA, Berg-Hansen P, Doskeland A, Mjaavatten O, Bos SD, Harbo HF, Berven F (2019)
Quantitative proteomic analyses of CD4(+) and CD8(+) T cells reveal differentially expressed proteins in multiple sclerosis patients and healthy controls
Clin. Proteom., 16, 19
DOI 10.1186/s12014-019-9241-5

Brorson IS, Eriksson A, Leikfoss IS, Celius EG, Berg-Hansen P, Barcellos LF, Berge T, Harbo HF, Bos SD (2019)
No differential gene expression for CD4(+) T cells of MS patients and healthy controls
Mult. Scler. J. Exp. Transl. Clin., 5 (2)
DOI 10.1177/2055217319856903

Madireddy L, Patsopoulos NA, Cotsapas C, Bos SD, Beecham A, McCauley J, Kim K, Jia XM, Santaniello A, Caillier SJ, Andlauer TFM, Barcellos LF, Berge T, Bernardinelli L, Martinelli-Boneschi F, Booth DR, Briggs F, Celius EG, Comabella M, Comi G, Cree BAC, D'Alfonso S, Dedham K, Duquette P, Dardiotis E et al. (2019)
A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis (vol 10, 2236, 2019)
Nat. Commun., 10, 2956
DOI 10.1038/s41467-019-10951-1

Madireddy L, Patsopoulos NA, Cotsapas C, Bos SD, Beecham A, McCauley J, Kim K, Jia XM, Santaniello A, Caillier SJ, Andlauer TFM, Barcellos LF, Berge T, Bernardinelli L, Martinelli-Boneschi F, Booth DR, Briggs F, Celius EG, Comabella M, Comi G, Cree BAC, D'Alfonso S, Dedham K, Duquette P, Efthimios D et al. (2019)
A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis
Nat. Commun., 10, 2236
DOI 10.1038/s41467-019-09773-y

Patsopoulos NA, Baranzini SE, Santaniello A, Shoostari P, Cotsapas C, Wong G, Beecham AH, James T, Replogle J, Vlachos IS, McCabe C, Pers TH, Brandes A, White C, Keenan B, Cimpean M, Winn P, Panteliadis IP, Robbins A, Andlauer TFM, Zarzycki O, Dubois B, Goris A, Sondergaard HB, Sellebjerg F et al. (2019)
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility
Science, 365 (6460), eaav7188-+
DOI 10.1126/science.aav7188

Publications 2018

Akhmadeev K, Houssein A, Moussaoui S, Hogestol EA, Tutturen I, Harbo HF, Bos-Haugen SD, Graves J, Laplaud DA, Gourraud PA (2018)
SVM-based Tool to Detect Patients with Multiple Sclerosis Using a Commercial EMG Sensor
PR IEEE SEN ARRAY, 376-379

Rhead B, Brorson IS, Berge T, Adams C, Quach H, Moen SM, Berg-Hansen P, Celius EG, Sangurdekar DP, Bronson PG, Lea RA, Burnard S, Maltby VE, Scott RJ, Lechner-Scott J, Harbo HF, Bos SD, Barcellos LF (2018)
Increased DNA methylation of SLFN12 in CD4(+) and CD8(+) T cells from multiple sclerosis patients
PLoS One, 13 (10), e0206511
DOI 10.1371/journal.pone.0206511

Publications 2017

Olafsson S, Stridh P, Bos SD, Ingason A, Euesden J, Sulem P, Thorleifsson G, Gustafsson O, Johannesson A, Geirsson AJ, Thorsson AV, Sigurgeirsson B, Ludviksson BR, Olafsson E, Kristjansdottir H, Jonasson JG, Olafsson JH, Orvar KB, Benediktsson R, Bjarnason R, Kristjansdottir S, Gislason T, Valdimarsson T, Mikaelsdottir E, Sigurdsson S et al. (2017)
Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations
npj Genom. Med., 2, 24
DOI 10.1038/s41525-017-0027-2

Publications 2016

George MF, Briggs FBS, Shao X, Gianfrancesco MA, Kockum I, Harbo HF, Celius EG, Bos SD, Hedstrom A, Shen L, Bernstein A, Alfredsson L, Hiller J, Olsson T, Patsopoulos NA, De Jager PL, Oturai AB, Sondergaard HB, Sellebjerg F, Sorensen PS, Gomez R, Caillier SJ, Cree BAC, Oksenberg JR, Hauser SL et al. (2016)
Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies
Neurol.-Genet., 2 (4), eB7
DOI 10.1212/NXG.00000000000000B7

Keshari PK, Harbo HF, Myhr KM, Aarseth JH, Bos SD, Berge T (2016)
Allelic imbalance of multiple sclerosis susceptibility genes IKZF3 and IQGAP1 in human peripheral blood
BMC Genet., 17, 59
DOI 10.1186/s12863-016-0367-4

Wang YP, Bos SD, Harbo HF, Thompson WK, Schork AJ, Bettella F, Witoelar A, Lie BA, Li W, McEvoy LK, Djurovic S, Desikan RS, Dale AM, Andreassen OA (2016)
Genetic overlap between multiple sclerosis and several cardiovascular disease risk factors
Mult. Scler. J., 22 (14), 1783-1793
DOI 10.1177/1352458516635873

Publications 2015

Bos SD, Page CM, Andreassen BK, Elboudwarej E, Gustavsen MW, Briggs F, Quach H, Leikfoss IS, Bjolgerud A, Berge T, Harbo HF, Barcellos LF (2015)
Genome-Wide DNA Methylation Profiles Indicate CD8+T Cell Hypermethylation in Multiple Sclerosis
PLoS One, 10 (3), e0117403
DOI 10.1371/journal.pone.0117403

Eriksen AB, Berge T, Gustavsen MW, Leikfoss IS, Bos SD, Spurkland A, Harbo HF, Blomhoff HK (2015)
Retinoic acid enhances the levels of IL-10 in TLR-stimulated B cells from patients with relapsing-remitting multiple sclerosis
J. Neuroimmunol., 278, 11-18
DOI 10.1016/j.jneuroim.2014.11.019

Goris A, Pauwels I, Gustavsen MW, van Son B, Hilven K, Bos SD, Celius EG, Berg-Hansen P, Aarseth J, Myhr KM, D'Alfonso S, Barizzone N, Leone MA, Boneschi FM, Sorosina M, Liberatore G, Kockum I, Olsson T, Hillert J, Alfredsson L, Bedri SK, Hemmer B, Buck D, Berthele A, Knier B et al. (2015)
Genetic variants are major determinants of CSF antibody levels in multiple sclerosis
Brain, 138, 632-643
DOI 10.1093/brain/awu405

Leikfoss IS, Keshari PK, Gustavsen MW, Bjolgerud A, Brorson IS, Celius EG, Spurkland A, Bos SD, Harbo HF, Berge T (2015)
Multiple Sclerosis Risk Allele in CLEC16A Acts as an Expression Quantitative Trait Locus for CLEC16A and SOCS1 in CD4+T Cells
PLoS One, 10 (7), e0132957
DOI 10.1371/journal.pone.0132957

Page CM, Baranzini SE, Mevik BH, Bos SD, Harbo HF, Andreassen BK (2015)
Assessing the Power of Exome Chips
PLoS One, 10 (10), e0139642
DOI 10.1371/journal.pone.0139642

Publications 2014

Harbo HF, Isobe N, Berg-Hansen P, Bos SD, Caillier SJ, Gustavsen MW, Mero IL, Celius EG, Hauser SL, Oksenberg JR, Gourraud PA (2014)
Oligoclonal bands and age at onset correlate with genetic risk score in multiple sclerosis
Mult. Scler. J., 20 (6), 660-668
DOI 10.1177/1352458513506503