On the cover:
Protein deposits (red) are not cleaned up in autophagy-deficient cells. This might lead to dementia, say Filimenko et al.
See article: "Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease" by Filimonenko M, Stuffers S, Raiborg C, Yamamoto A, Malerød L, Fisher EM, Isaacs A, Brech A, Stenmark H, Simonsen A., J Cell Biol. 2007 Nov 5;179(3):485-500.