Publications by Karl-Johan Malmberg
83 publications found
Publications 2019
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Imbalance of Genes Encoding Natural Killer Immunoglobulin-Like Receptors and Human Leukocyte Antigen in Patients With Biliary Cancer
Gastroenterology, 157 (4), 1067-1080.e9
DOI 10.1053/j.gastro.2019.06.023, PubMed 31229495 -
Systemic and Intra-Nodal Activation of NK Cells After Rituximab Monotherapy for Follicular Lymphoma
Front Immunol, 10, 2085
DOI 10.3389/fimmu.2019.02085, PubMed 31572357 -
Remodeling of secretory lysosomes during education tunes functional potential in NK cells
Nat Commun, 10 (1), 514
DOI 10.1038/s41467-019-08384-x, PubMed 30705279 -
Intra-lineage Plasticity and Functional Reprogramming Maintain Natural Killer Cell Repertoire Diversity
Cell Rep, 29 (8), 2284-2294.e4
DOI 10.1016/j.celrep.2019.10.058, PubMed 31747601
Publications 2018
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Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML
Clin Cancer Res, 24 (8), 1834-1844
DOI 10.1158/1078-0432.CCR-17-3196, PubMed 29444931 -
Innovative therapy, monoclonal antibodies, and beyond: Highlights from the eighth annual meeting
Cytokine Growth Factor Rev, 44, 1-10
DOI 10.1016/j.cytogfr.2018.10.005, PubMed 30393044 -
Induction of the BIM Short Splice Variant Sensitizes Proliferating NK Cells to IL-15 Withdrawal
J Immunol, 202 (3), 736-746
DOI 10.4049/jimmunol.1801146, PubMed 30578306 -
Intrinsic Functional Potential of NK-Cell Subsets Constrains Retargeting Driven by Chimeric Antigen Receptors
Cancer Immunol Res, 6 (4), 467-480
DOI 10.1158/2326-6066.CIR-17-0207, PubMed 29459477 -
Off-the-shelf cell therapy with induced pluripotent stem cell-derived natural killer cells
Semin Immunopathol, 41 (1), 59-68
DOI 10.1007/s00281-018-0721-x, PubMed 30361801
Publications 2017
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Bioinformatics Approaches to Profile the Tumor Microenvironment for Immunotherapeutic Discovery
Curr Pharm Des, 23 (32), 4716-4725
DOI 10.2174/1381612823666170710154936, PubMed 28699527 -
Ex Vivo Expanded Adaptive NK Cells Effectively Kill Primary Acute Lymphoblastic Leukemia Cells
Cancer Immunol Res, 5 (8), 654-665
DOI 10.1158/2326-6066.CIR-16-0296, PubMed 28637877 -
Natural killer cell-mediated immunosurveillance of human cancer
Semin Immunol, 31, 20-29
DOI 10.1016/j.smim.2017.08.002, PubMed 28888619 -
Immune selection during tumor checkpoint inhibition therapy paves way for NK-cell "missing self" recognition
Immunogenetics, 69 (8-9), 547-556
DOI 10.1007/s00251-017-1011-9, PubMed 28699110 -
CD56bright NK cells exhibit potent antitumor responses following IL-15 priming
J Clin Invest, 127 (11), 4042-4058
DOI 10.1172/JCI90387, PubMed 28972539
Publications 2016
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Naive Donor NK Cell Repertoires Associated with Less Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation
J Immunol, 196 (3), 1400-11
DOI 10.4049/jimmunol.1501434, PubMed 26746188 -
Class I HLA haplotypes form two schools that educate NK cells in different ways
Sci Immunol, 1 (3)
DOI 10.1126/sciimmunol.aag1672, PubMed 27868107 -
Cognate HLA absence in trans diminishes human NK cell education
J Clin Invest, 126 (10), 3772-3782
DOI 10.1172/JCI86923, PubMed 27571408 -
Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans
Cell Rep, 15 (5), 1088-1099
DOI 10.1016/j.celrep.2016.04.005, PubMed 27117418 -
Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA
Oncoimmunology, 5 (5), e1138199
DOI 10.1080/2162402X.2016.1138199, PubMed 27467957
Publications 2015
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Polyclonal Expansion of NKG2C(+) NK Cells in TAP-Deficient Patients
Front Immunol, 6, 507
DOI 10.3389/fimmu.2015.00507, PubMed 26500647 -
Coordinated expression of DNAM-1 and LFA-1 in educated NK cells
J Immunol, 194 (9), 4518-27
DOI 10.4049/jimmunol.1401972, PubMed 25825444 -
Microchip-Based Single-Cell Imaging Reveals That CD56dimCD57-KIR-NKG2A+ NK Cells Have More Dynamic Migration Associated with Increased Target Cell Conjugation and Probability of Killing Compared to CD56dimCD57-KIR-NKG2A- NK Cells
J Immunol, 195 (7), 3374-81
DOI 10.4049/jimmunol.1500171, PubMed 26320254 -
Newtonian cell interactions shape natural killer cell education
Immunol Rev, 267 (1), 197-213
DOI 10.1111/imr.12325, PubMed 26284479 -
Harnessing adaptive natural killer cells in cancer immunotherapy
Mol Oncol, 9 (10), 1904-17
DOI 10.1016/j.molonc.2015.10.001, PubMed 26604011 -
Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function
Immunity, 42 (3), 443-56
DOI 10.1016/j.immuni.2015.02.008, PubMed 25786176 -
Impact of KIR and HLA Genotypes on Outcomes after Reduced-Intensity Conditioning Hematopoietic Cell Transplantation
Biol Blood Marrow Transplant, 21 (9), 1589-96
DOI 10.1016/j.bbmt.2015.05.002, PubMed 25960307 -
Imprint of 5-azacytidine on the natural killer cell repertoire during systemic treatment for high-risk myelodysplastic syndrome
Oncotarget, 6 (33), 34178-90
DOI 10.18632/oncotarget.6213, PubMed 26497557 -
Increased incidence of chronic GvHD and CMV disease in patients with vitamin D deficiency before allogeneic stem cell transplantation
Bone Marrow Transplant, 50 (9), 1217-23
DOI 10.1038/bmt.2015.123, PubMed 26030049
Publications 2014
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Role for early-differentiated natural killer cells in infectious mononucleosis
Blood, 124 (16), 2533-43
DOI 10.1182/blood-2014-01-553024, PubMed 25205117 -
Tracing dynamic expansion of human NK-cell subsets by high-resolution analysis of KIR repertoires and cellular differentiation
Eur J Immunol, 44 (7), 2192-6
DOI 10.1002/eji.201444464, PubMed 24723455 -
Effects of HDV infection and pegylated interferon α treatment on the natural killer cell compartment in chronically infected individuals
Gut, 64 (3), 469-82
DOI 10.1136/gutjnl-2014-306767, PubMed 24721903 -
Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease
Blood, 124 (5), 812-21
DOI 10.1182/blood-2013-11-536888, PubMed 24855210
Publications 2013
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Independent skewing of the T cell and NK cell compartments associated with cytomegalovirus infection suggests division of labor between innate and adaptive immunity
Age (Dordr), 36 (2), 571-82
DOI 10.1007/s11357-013-9587-y, PubMed 24065293 -
NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs
Blood, 121 (14), 2678-88
DOI 10.1182/blood-2012-10-459545, PubMed 23325834 -
Influence of KIR gene copy number on natural killer cell education
Blood, 121 (23), 4703-7
DOI 10.1182/blood-2012-10-461442, PubMed 23637128 -
Natural killer cell inhibitory receptor expression in humans and mice: a closer look
Front Immunol, 4, 65
DOI 10.3389/fimmu.2013.00065, PubMed 23532016 -
Classification of human natural killer cells based on migration behavior and cytotoxic response
Blood, 121 (8), 1326-34
DOI 10.1182/blood-2012-06-439851, PubMed 23287857
Publications 2012
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CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells
Blood, 120 (17), 3455-65
DOI 10.1182/blood-2012-03-416867, PubMed 22968455 -
Toward a prime-boost regime for NK cells?
Blood, 120 (24), 4663-4
DOI 10.1182/blood-2012-09-457184, PubMed 23223209 -
Spotlight on NKG2C and the human NK-cell response to CMV infection
Eur J Immunol, 42 (12), 3141-5
DOI 10.1002/eji.201243050, PubMed 23255011
Publications 2011
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CMV drives clonal expansion of NKG2C+ NK cells expressing self-specific KIRs in chronic hepatitis patients
Eur J Immunol, 42 (2), 447-57
DOI 10.1002/eji.201141826, PubMed 22105371 -
Characterization of natural killer cell phenotype and function during recurrent human HSV-2 infection
PLoS One, 6 (11), e27664
DOI 10.1371/journal.pone.0027664, PubMed 22110712 -
Selenite induces posttranscriptional blockade of HLA-E expression and sensitizes tumor cells to CD94/NKG2A-positive NK cells
J Immunol, 187 (7), 3546-54
DOI 10.4049/jimmunol.1100610, PubMed 21890659 -
NKG2D performs two functions in invariant NKT cells: direct TCR-independent activation of NK-like cytolysis and co-stimulation of activation by CD1d
Eur J Immunol, 41 (7), 1913-23
DOI 10.1002/eji.200940278, PubMed 21590763 -
Killer cell immunoglobulin-like receptor workshop: insights into evolution, genetics, function, and translation
Immunity, 35 (5), 653-7
DOI 10.1016/j.immuni.2011.11.007, PubMed 22118518 -
Improved survival after allogeneic hematopoietic stem cell transplantation in recent years. A single-center study
Biol Blood Marrow Transplant, 17 (11), 1688-97
DOI 10.1016/j.bbmt.2011.05.001, PubMed 21620989
Publications 2010
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Tolerant and diverse natural killer cell repertoires in the absence of selection
Exp Cell Res, 316 (8), 1309-15
DOI 10.1016/j.yexcr.2010.02.030, PubMed 20206161 -
NK cells expressing inhibitory KIR for non-self-ligands remain tolerant in HLA-matched sibling stem cell transplantation
Blood, 115 (13), 2686-94
DOI 10.1182/blood-2009-07-229740, PubMed 20097883 -
Analysis of the KIR repertoire in human NK cells by flow cytometry
Methods Mol Biol, 612, 353-64
DOI 10.1007/978-1-60761-362-6_24, PubMed 20033653 -
Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus
J Exp Med, 208 (1), 13-21
DOI 10.1084/jem.20100762, PubMed 21173105 -
Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education
Blood, 116 (19), 3853-64
DOI 10.1182/blood-2010-04-281675, PubMed 20696944 -
Reduced DNAM-1 expression on bone marrow NK cells associated with impaired killing of CD34+ blasts in myelodysplastic syndrome
Leukemia, 24 (9), 1607-16
DOI 10.1038/leu.2010.149, PubMed 20613786 -
Activating NK-cell receptors co-stimulate CD4(+)CD28(-) T cells in patients with rheumatoid arthritis
Eur J Immunol, 40 (2), 378-87
DOI 10.1002/eji.200939399, PubMed 19904767 -
Distinct infiltration of neutrophils in lesion shoulders in ApoE-/- mice
Am J Pathol, 177 (1), 493-500
DOI 10.2353/ajpath.2010.090480, PubMed 20472897 -
Identification of a novel KIR3DL1*072 allele by sequence-based typing
Tissue Antigens, 76 (1), 74-5
DOI 10.1111/j.1399-0039.2010.01464.x, PubMed 20210921 -
Interactions of NK cell receptor KIR3DL1*004 with chaperones and conformation-specific antibody reveal a functional folded state as well as predominant intracellular retention
J Immunol, 186 (1), 62-72
DOI 10.4049/jimmunol.0903657, PubMed 21115737
Publications 2009
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KIR acquisition probabilities are independent of self-HLA class I ligands and increase with cellular KIR expression
Blood, 114 (1), 95-104
DOI 10.1182/blood-2008-10-184549, PubMed 19304956 -
Natural killer cell-mediated lysis of freshly isolated human tumor cells
Int J Cancer, 124 (4), 757-62
DOI 10.1002/ijc.24082, PubMed 19035446 -
Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cells
J Immunol, 183 (8), 4921-30
DOI 10.4049/jimmunol.0901226, PubMed 19801517 -
Regulation of interleukin-4 signaling by extracellular reduction of intramolecular disulfides
Biochem Biophys Res Commun, 390 (4), 1272-7
DOI 10.1016/j.bbrc.2009.10.134, PubMed 19878651 -
T cell infiltrates in the muscles of patients with dermatomyositis and polymyositis are dominated by CD28null T cells
J Immunol, 183 (7), 4792-9
DOI 10.4049/jimmunol.0803688, PubMed 19752224 -
Education of human natural killer cells by activating killer cell immunoglobulin-like receptors
Blood, 115 (6), 1166-74
DOI 10.1182/blood-2009-09-245746, PubMed 19903900 -
Spotlight on IL-22-producing NK cell receptor-expressing mucosal lymphocytes
Nat Immunol, 10 (1), 11-2
DOI 10.1038/ni0109-11, PubMed 19088733
Publications 2008
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Elevated numbers of Fc gamma RIIIA+ (CD16+) effector CD8 T cells with NK cell-like function in chronic hepatitis C virus infection
J Immunol, 181 (6), 4219-28
DOI 10.4049/jimmunol.181.6.4219, PubMed 18768879 -
Estimation of the size of the alloreactive NK cell repertoire: studies in individuals homozygous for the group A KIR haplotype
J Immunol, 181 (9), 6010-9
DOI 10.4049/jimmunol.181.9.6010, PubMed 18941190 -
NK cell-mediated targeting of human cancer and possibilities for new means of immunotherapy
Cancer Immunol Immunother, 57 (10), 1541-52
DOI 10.1007/s00262-008-0492-7, PubMed 18317755
Publications 2007
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DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells
Cancer Res, 67 (3), 1317-25
DOI 10.1158/0008-5472.CAN-06-2264, PubMed 17283169 -
Application of nine-color flow cytometry for detailed studies of the phenotypic complexity and functional heterogeneity of human lymphocyte subsets
J Immunol Methods, 330 (1-2), 64-74
DOI 10.1016/j.jim.2007.10.020, PubMed 18083186 -
The CD16- CD56(bright) NK cell subset is resistant to reactive oxygen species produced by activated granulocytes and has higher antioxidative capacity than the CD16+ CD56(dim) subset
J Immunol, 179 (7), 4513-9
DOI 10.4049/jimmunol.179.7.4513, PubMed 17878347 -
IFN-gamma production dominates the early human natural killer cell response to Coxsackievirus infection
Cell Microbiol, 10 (2), 426-36
DOI 10.1111/j.1462-5822.2007.01056.x, PubMed 17961184 -
Prospects for the use of NK cells in immunotherapy of human cancer
Nat Rev Immunol, 7 (5), 329-39
DOI 10.1038/nri2073, PubMed 17438573
Publications 2006
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A short-term dietary supplementation with high doses of vitamin E increases NK cell cytolytic activity in advanced colorectal cancer patients
Cancer Immunol Immunother, 56 (7), 973-84
DOI 10.1007/s00262-006-0261-4, PubMed 17143612 -
Frequent loss of HLA-A2 expression in metastasizing ovarian carcinomas associated with genomic haplotype loss and HLA-A2-restricted HER-2/neu-specific immunity
Cancer Res, 66 (12), 6387-94
DOI 10.1158/0008-5472.CAN-06-0029, PubMed 16778217
Publications 2005
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Escape from immune- and nonimmune-mediated tumor surveillance
Semin Cancer Biol, 16 (1), 16-31
DOI 10.1016/j.semcancer.2005.07.007, PubMed 16140546 -
KIR-ligand mismatch in allogeneic hematopoietic stem cell transplantation
Mol Immunol, 42 (4), 531-4
DOI 10.1016/j.molimm.2004.07.037, PubMed 15607809 -
Preferential cell death of CD8+ effector memory (CCR7-CD45RA-) T cells by hydrogen peroxide-induced oxidative stress
J Immunol, 174 (10), 6080-7
DOI 10.4049/jimmunol.174.10.6080, PubMed 15879102
Publications 2004
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Effective immunotherapy against cancer: a question of overcoming immune suppression and immune escape?
Cancer Immunol Immunother, 53 (10), 879-92
DOI 10.1007/s00262-004-0577-x, PubMed 15338206 -
Increased infection-related mortality in KIR-ligand-mismatched unrelated allogeneic hematopoietic stem-cell transplantation
Transplantation, 78 (7), 1081-5
DOI 10.1097/01.tp.0000137103.19717.86, PubMed 15480179
Publications 2002
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A short-term dietary supplementation of high doses of vitamin E increases T helper 1 cytokine production in patients with advanced colorectal cancer
Clin Cancer Res, 8 (6), 1772-8
PubMed 12060616 -
IFN-gamma protects short-term ovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism
J Clin Invest, 110 (10), 1515-23
DOI 10.1172/JCI15564, PubMed 12438449
Publications 2001
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The identification of a common pathogen-specific HLA class I A*0201-restricted cytotoxic T cell epitope encoded within the heat shock protein 65
Eur J Immunol, 31 (12), 3602-11
DOI 10.1002/1521-4141(200112)31:12<3602::aid-immu3602>3.0.co;2-l, PubMed 11745380 -
Inhibition of activated/memory (CD45RO(+)) T cells by oxidative stress associated with block of NF-kappaB activation
J Immunol, 167 (5), 2595-601
DOI 10.4049/jimmunol.167.5.2595, PubMed 11509600
Publications 1999
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Identification of new HER2/neu-derived peptide epitopes that can elicit specific CTL against autologous and allogeneic carcinomas and melanomas
J Immunol, 163 (2), 1037-44
PubMed 10395702