Karl-Johan Malmberg
- Professor; MD, PhD
- +47 22 78 13 26
Publications 2024
MetaGate: Interactive analysis of high-dimensional cytometry data with metadata integration
Patterns (N Y), 5 (7), 100989
DOI 10.1016/j.patter.2024.100989, PubMed 39081571
Systematic evaluation of donor-KIR/recipient-HLA interactions in HLA-matched hematopoietic cell transplantation for AML
Blood Adv, 8 (3), 581-590
DOI 10.1182/bloodadvances.2023011622, PubMed 38052043
Genetic ablation of adhesion ligands mitigates rejection of allogeneic cellular immunotherapies
Cell Stem Cell, 31 (9), 1376-1386.e8
DOI 10.1016/j.stem.2024.06.011, PubMed 38981470
Engineering immune-evasive allogeneic cellular immunotherapies
Nat Rev Immunol, 24 (9), 680-693
DOI 10.1038/s41577-024-01022-8, PubMed 38658708
Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping
Nat Immunol, 25 (8), 1445-1459
DOI 10.1038/s41590-024-01884-z, PubMed 38956379
The G Protein-Coupled Receptor GPR56 Is an Inhibitory Checkpoint for NK Cell Migration
J Immunol, 213 (9), 1349-1357
DOI 10.4049/jimmunol.2400228, PubMed 39320215
Egr2 to the rescue: nanoparticles revitalize natural killer cells in the fight against cancer
EMBO J, 43 (13), 2527-2529
DOI 10.1038/s44318-024-00144-y, PubMed 38886578
High-dimensional single-cell analysis of human natural killer cell heterogeneity
Nat Immunol, 25 (8), 1474-1488
DOI 10.1038/s41590-024-01883-0, PubMed 38956378
The HLA-B -21 M/T dimorphism associates with disease severity in COVID-19
Genes Immun (in press)
DOI 10.1038/s41435-024-00302-6, PubMed 39487235
Targeting HLA-E-overexpressing cancers with a NKG2A/C switch receptor
Med (in press)
DOI 10.1016/j.medj.2024.09.010, PubMed 39423821
A temporal developmental map separates human NK cells from noncytotoxic ILCs through clonal and single-cell analysis
Blood Adv, 8 (11), 2933-2951
DOI 10.1182/bloodadvances.2023011909, PubMed 38484189
Publications 2023
MetaGate: Interactive Analysis of High-Dimensional Cytometry Data with Meta Data Integration
bioRxiv
DOI 10.1101/2023.10.27.564454, PubMed 37961421
The Lysosomal Calcium Channel TRPML1 Maintains Mitochondrial Fitness in NK Cells through Interorganelle Cross-Talk
J Immunol, 211 (9), 1348-1358
DOI 10.4049/jimmunol.2300406, PubMed 37737664
Affibody-based hBCMA x CD16 dual engagers for NK cell-mediated killing of multiple myeloma cells
N Biotechnol, 77, 139-148
DOI 10.1016/j.nbt.2023.09.002, PubMed 37673373
Genetic ablation of adhesion ligands averts rejection of allogeneic immune cells
bioRxiv
DOI 10.1101/2023.10.09.557143, PubMed 37873468
Effect of mTOR Inhibition with Sirolimus on Natural Killer Cell Reconstitution in Allogeneic Stem Cell Transplantation
Transplant Cell Ther, 29 (6), 376.e1-376.e11
DOI 10.1016/j.jtct.2023.03.023, PubMed 36966873
Functional SARS-CoV-2 cross-reactive CD4+ T cells established in early childhood decline with age
Proc Natl Acad Sci U S A, 120 (12), e2220320120
DOI 10.1073/pnas.2220320120, PubMed 36917669
Mapping the chemotactic landscape in NK cells reveals subset-specific synergistic migratory responses to dual chemokine receptor ligation
EBioMedicine, 96, 104811
DOI 10.1016/j.ebiom.2023.104811, PubMed 37741009
Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia
Respir Res, 24 (1), 62
DOI 10.1186/s12931-023-02364-y, PubMed 36829233
Allelic variation of KIR and HLA tunes the cytolytic payload and determines functional hierarchy of NK cell repertoires
Blood Adv, 7 (16), 4492-4504
DOI 10.1182/bloodadvances.2023009827, PubMed 37327114
Modulation of lytic molecules restrain serial killing in γδ T lymphocytes
Nat Commun, 14 (1), 6035
DOI 10.1038/s41467-023-41634-7, PubMed 37758698
Publications 2022
PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells
J Immunother Cancer, 10 (1)
DOI 10.1136/jitc-2021-002500, PubMed 35078921
Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma
Nat Commun, 13 (1), 7341
DOI 10.1038/s41467-022-35127-2, PubMed 36446823
SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells
Cell Rep, 38 (10), 110503
DOI 10.1016/j.celrep.2022.110503, PubMed 35235832
Adaptive single-KIR+NKG2C+ NK cells expanded from select superdonors show potent missing-self reactivity and efficiently control HLA-mismatched acute myeloid leukemia
J Immunother Cancer, 10 (11)
DOI 10.1136/jitc-2022-005577, PubMed 36319065
The Karolinska KI/K COVID-19 Immune Atlas: An open resource for immunological research and educational purposes
Scand J Immunol, 96 (1), e13195 (in press)
DOI 10.1111/sji.13195, PubMed 35652743
Small Interfering RNA Delivery Into Primary Human Natural Killer Cells for Functional Gene Analyses
Curr Protoc, 2 (11), e613
DOI 10.1002/cpz1.613, PubMed 36440989
An optimized platform for efficient siRNA delivery into human NK cells
Eur J Immunol, 52 (7), 1190-1193
DOI 10.1002/eji.202149710, PubMed 35416292
NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer
Cancer Cell, 40 (9), 1027-1043.e9
DOI 10.1016/j.ccell.2022.08.005, PubMed 36099881
Expansion, persistence, and efficacy of donor memory-like NK cells infused for posttransplant relapse
J Clin Invest, 132 (11)
DOI 10.1172/JCI154334, PubMed 35349491
Perturbed NK-cell homeostasis associated with disease severity in chronic neutropenia
Blood, 139 (5), 704-716
DOI 10.1182/blood.2021013233, PubMed 34699594
Publications 2021
Anti-NKG2C/IL-15/anti-CD33 killer engager directs primary and iPSC-derived NKG2C+ NK cells to target myeloid leukemia
Mol Ther, 29 (12), 3410-3421
DOI 10.1016/j.ymthe.2021.06.018, PubMed 34174441
PRDX-1 Supports the Survival and Antitumor Activity of Primary and CAR-Modified NK Cells under Oxidative Stress
Cancer Immunol Res, 10 (2), 228-244
DOI 10.1158/2326-6066.CIR-20-1023, PubMed 34853030
Bioinformatic Analysis Reveals Central Role for Tumor-Infiltrating Immune Cells in Uveal Melanoma Progression
J Immunol Res, 2021, 9920234
DOI 10.1155/2021/9920234, PubMed 34195299
High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19
Proc Natl Acad Sci U S A, 118 (40)
DOI 10.1073/pnas.2109123118, PubMed 34548411
Advances in immune therapies in hematological malignancies
J Intern Med, 292 (2), 205-220
DOI 10.1111/joim.13395, PubMed 34624160
Natural killer cell receptors regulate responses of HLA-E-restricted T cells
Sci Immunol, 6 (58)
DOI 10.1126/sciimmunol.abe9057, PubMed 33893172
Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy
Cell Stem Cell, 28 (12), 2062-2075.e5
DOI 10.1016/j.stem.2021.08.013, PubMed 34525347
Publications 2020
A Systemic Protein Deviation Score Linked to PD-1+ CD8+ T Cell Expansion That Predicts Overall Survival in Diffuse Large B Cell Lymphoma
Med, 2 (2), 180-195.e5
DOI 10.1016/j.medj.2020.10.006, PubMed 35590201
TRP Channels as Interior Designers: Remodeling the Endolysosomal Compartment in Natural Killer Cells
Front Immunol, 11, 753
DOI 10.3389/fimmu.2020.00753, PubMed 32411146
Umbilical Cord Blood and iPSC-Derived Natural Killer Cells Demonstrate Key Differences in Cytotoxic Activity and KIR Profiles
Front Immunol, 11, 561553
DOI 10.3389/fimmu.2020.561553, PubMed 33178188
The Oncometabolite 5'-Deoxy-5'-Methylthioadenosine Blocks Multiple Signaling Pathways of NK Cell Activation
Front Immunol, 11, 2128
DOI 10.3389/fimmu.2020.02128, PubMed 33123121
Prospects for NK Cell Therapy of Sarcoma
Cancers (Basel), 12 (12)
DOI 10.3390/cancers12123719, PubMed 33322371
Natural killer cell immunotypes related to COVID-19 disease severity
Sci Immunol, 5 (50)
DOI 10.1126/sciimmunol.abd6832, PubMed 32826343
Preventing a shock to the system. Two-pore channel 1 negatively regulates anaphylaxis
Cell Calcium, 92, 102289
DOI 10.1016/j.ceca.2020.102289, PubMed 33027744
Deciphering Natural Killer Cell Homeostasis
Front Immunol, 11, 812
DOI 10.3389/fimmu.2020.00812, PubMed 32477340
Cellular immunotherapy with multiple infusions of in vitro-expanded haploidentical natural killer cells after autologous transplantation for patients with plasma cell myeloma
Cytotherapy, 23 (4), 329-338
DOI 10.1016/j.jcyt.2020.09.009, PubMed 33268029
Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity
Cell Stem Cell, 27 (2), 224-237.e6
DOI 10.1016/j.stem.2020.05.008, PubMed 32531207
Publications 2019
Imbalance of Genes Encoding Natural Killer Immunoglobulin-Like Receptors and Human Leukocyte Antigen in Patients With Biliary Cancer
Gastroenterology, 157 (4), 1067-1080.e9
DOI 10.1053/j.gastro.2019.06.023, PubMed 31229495
Systemic and Intra-Nodal Activation of NK Cells After Rituximab Monotherapy for Follicular Lymphoma
Front Immunol, 10, 2085
DOI 10.3389/fimmu.2019.02085, PubMed 31572357
Remodeling of secretory lysosomes during education tunes functional potential in NK cells
Nat Commun, 10 (1), 514
DOI 10.1038/s41467-019-08384-x, PubMed 30705279
Intra-lineage Plasticity and Functional Reprogramming Maintain Natural Killer Cell Repertoire Diversity
Cell Rep, 29 (8), 2284-2294.e4
DOI 10.1016/j.celrep.2019.10.058, PubMed 31747601
Publications 2018
Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML
Clin Cancer Res, 24 (8), 1834-1844
DOI 10.1158/1078-0432.CCR-17-3196, PubMed 29444931
Innovative therapy, monoclonal antibodies, and beyond: Highlights from the eighth annual meeting
Cytokine Growth Factor Rev, 44, 1-10
DOI 10.1016/j.cytogfr.2018.10.005, PubMed 30393044
Induction of the BIM Short Splice Variant Sensitizes Proliferating NK Cells to IL-15 Withdrawal
J Immunol, 202 (3), 736-746
DOI 10.4049/jimmunol.1801146, PubMed 30578306
Intrinsic Functional Potential of NK-Cell Subsets Constrains Retargeting Driven by Chimeric Antigen Receptors
Cancer Immunol Res, 6 (4), 467-480
DOI 10.1158/2326-6066.CIR-17-0207, PubMed 29459477
Off-the-shelf cell therapy with induced pluripotent stem cell-derived natural killer cells
Semin Immunopathol, 41 (1), 59-68
DOI 10.1007/s00281-018-0721-x, PubMed 30361801
Publications 2017
Bioinformatics Approaches to Profile the Tumor Microenvironment for Immunotherapeutic Discovery
Curr Pharm Des, 23 (32), 4716-4725
DOI 10.2174/1381612823666170710154936, PubMed 28699527
Ex Vivo Expanded Adaptive NK Cells Effectively Kill Primary Acute Lymphoblastic Leukemia Cells
Cancer Immunol Res, 5 (8), 654-665
DOI 10.1158/2326-6066.CIR-16-0296, PubMed 28637877
Natural killer cell-mediated immunosurveillance of human cancer
Semin Immunol, 31, 20-29
DOI 10.1016/j.smim.2017.08.002, PubMed 28888619
Immune selection during tumor checkpoint inhibition therapy paves way for NK-cell "missing self" recognition
Immunogenetics, 69 (8-9), 547-556
DOI 10.1007/s00251-017-1011-9, PubMed 28699110
CD56bright NK cells exhibit potent antitumor responses following IL-15 priming
J Clin Invest, 127 (11), 4042-4058
DOI 10.1172/JCI90387, PubMed 28972539
Publications 2016
Naive Donor NK Cell Repertoires Associated with Less Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation
J Immunol, 196 (3), 1400-11
DOI 10.4049/jimmunol.1501434, PubMed 26746188
Class I HLA haplotypes form two schools that educate NK cells in different ways
Sci Immunol, 1 (3)
DOI 10.1126/sciimmunol.aag1672, PubMed 27868107
Cognate HLA absence in trans diminishes human NK cell education
J Clin Invest, 126 (10), 3772-3782
DOI 10.1172/JCI86923, PubMed 27571408
Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans
Cell Rep, 15 (5), 1088-1099
DOI 10.1016/j.celrep.2016.04.005, PubMed 27117418
Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA
Oncoimmunology, 5 (5), e1138199
DOI 10.1080/2162402X.2016.1138199, PubMed 27467957
Publications 2015
Polyclonal Expansion of NKG2C(+) NK Cells in TAP-Deficient Patients
Front Immunol, 6, 507
DOI 10.3389/fimmu.2015.00507, PubMed 26500647
Coordinated expression of DNAM-1 and LFA-1 in educated NK cells
J Immunol, 194 (9), 4518-27
DOI 10.4049/jimmunol.1401972, PubMed 25825444
Microchip-Based Single-Cell Imaging Reveals That CD56dimCD57-KIR-NKG2A+ NK Cells Have More Dynamic Migration Associated with Increased Target Cell Conjugation and Probability of Killing Compared to CD56dimCD57-KIR-NKG2A- NK Cells
J Immunol, 195 (7), 3374-81
DOI 10.4049/jimmunol.1500171, PubMed 26320254
Newtonian cell interactions shape natural killer cell education
Immunol Rev, 267 (1), 197-213
DOI 10.1111/imr.12325, PubMed 26284479
Harnessing adaptive natural killer cells in cancer immunotherapy
Mol Oncol, 9 (10), 1904-17
DOI 10.1016/j.molonc.2015.10.001, PubMed 26604011
Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function
Immunity, 42 (3), 443-56
DOI 10.1016/j.immuni.2015.02.008, PubMed 25786176
Impact of KIR and HLA Genotypes on Outcomes after Reduced-Intensity Conditioning Hematopoietic Cell Transplantation
Biol Blood Marrow Transplant, 21 (9), 1589-96
DOI 10.1016/j.bbmt.2015.05.002, PubMed 25960307
Imprint of 5-azacytidine on the natural killer cell repertoire during systemic treatment for high-risk myelodysplastic syndrome
Oncotarget, 6 (33), 34178-90
DOI 10.18632/oncotarget.6213, PubMed 26497557
Increased incidence of chronic GvHD and CMV disease in patients with vitamin D deficiency before allogeneic stem cell transplantation
Bone Marrow Transplant, 50 (9), 1217-23
DOI 10.1038/bmt.2015.123, PubMed 26030049
Publications 2014
Role for early-differentiated natural killer cells in infectious mononucleosis
Blood, 124 (16), 2533-43
DOI 10.1182/blood-2014-01-553024, PubMed 25205117
Tracing dynamic expansion of human NK-cell subsets by high-resolution analysis of KIR repertoires and cellular differentiation
Eur J Immunol, 44 (7), 2192-6
DOI 10.1002/eji.201444464, PubMed 24723455
Effects of HDV infection and pegylated interferon α treatment on the natural killer cell compartment in chronically infected individuals
Gut, 64 (3), 469-82
DOI 10.1136/gutjnl-2014-306767, PubMed 24721903
Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease
Blood, 124 (5), 812-21
DOI 10.1182/blood-2013-11-536888, PubMed 24855210
Publications 2013
Independent skewing of the T cell and NK cell compartments associated with cytomegalovirus infection suggests division of labor between innate and adaptive immunity
Age (Dordr), 36 (2), 571-82
DOI 10.1007/s11357-013-9587-y, PubMed 24065293
NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs
Blood, 121 (14), 2678-88
DOI 10.1182/blood-2012-10-459545, PubMed 23325834
Influence of KIR gene copy number on natural killer cell education
Blood, 121 (23), 4703-7
DOI 10.1182/blood-2012-10-461442, PubMed 23637128
Natural killer cell inhibitory receptor expression in humans and mice: a closer look
Front Immunol, 4, 65
DOI 10.3389/fimmu.2013.00065, PubMed 23532016
Classification of human natural killer cells based on migration behavior and cytotoxic response
Blood, 121 (8), 1326-34
DOI 10.1182/blood-2012-06-439851, PubMed 23287857
Publications 2012
CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells
Blood, 120 (17), 3455-65
DOI 10.1182/blood-2012-03-416867, PubMed 22968455
Toward a prime-boost regime for NK cells?
Blood, 120 (24), 4663-4
DOI 10.1182/blood-2012-09-457184, PubMed 23223209
Spotlight on NKG2C and the human NK-cell response to CMV infection
Eur J Immunol, 42 (12), 3141-5
DOI 10.1002/eji.201243050, PubMed 23255011
Publications 2011
CMV drives clonal expansion of NKG2C+ NK cells expressing self-specific KIRs in chronic hepatitis patients
Eur J Immunol, 42 (2), 447-57
DOI 10.1002/eji.201141826, PubMed 22105371
Characterization of natural killer cell phenotype and function during recurrent human HSV-2 infection
PLoS One, 6 (11), e27664
DOI 10.1371/journal.pone.0027664, PubMed 22110712
Selenite induces posttranscriptional blockade of HLA-E expression and sensitizes tumor cells to CD94/NKG2A-positive NK cells
J Immunol, 187 (7), 3546-54
DOI 10.4049/jimmunol.1100610, PubMed 21890659
NKG2D performs two functions in invariant NKT cells: direct TCR-independent activation of NK-like cytolysis and co-stimulation of activation by CD1d
Eur J Immunol, 41 (7), 1913-23
DOI 10.1002/eji.200940278, PubMed 21590763
Killer cell immunoglobulin-like receptor workshop: insights into evolution, genetics, function, and translation
Immunity, 35 (5), 653-7
DOI 10.1016/j.immuni.2011.11.007, PubMed 22118518
Improved survival after allogeneic hematopoietic stem cell transplantation in recent years. A single-center study
Biol Blood Marrow Transplant, 17 (11), 1688-97
DOI 10.1016/j.bbmt.2011.05.001, PubMed 21620989
Publications 2010
Tolerant and diverse natural killer cell repertoires in the absence of selection
Exp Cell Res, 316 (8), 1309-15
DOI 10.1016/j.yexcr.2010.02.030, PubMed 20206161
NK cells expressing inhibitory KIR for non-self-ligands remain tolerant in HLA-matched sibling stem cell transplantation
Blood, 115 (13), 2686-94
DOI 10.1182/blood-2009-07-229740, PubMed 20097883
Analysis of the KIR repertoire in human NK cells by flow cytometry
Methods Mol Biol, 612, 353-64
DOI 10.1007/978-1-60761-362-6_24, PubMed 20033653
Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus
J Exp Med, 208 (1), 13-21
DOI 10.1084/jem.20100762, PubMed 21173105
Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education
Blood, 116 (19), 3853-64
DOI 10.1182/blood-2010-04-281675, PubMed 20696944
Reduced DNAM-1 expression on bone marrow NK cells associated with impaired killing of CD34+ blasts in myelodysplastic syndrome
Leukemia, 24 (9), 1607-16
DOI 10.1038/leu.2010.149, PubMed 20613786
Activating NK-cell receptors co-stimulate CD4(+)CD28(-) T cells in patients with rheumatoid arthritis
Eur J Immunol, 40 (2), 378-87
DOI 10.1002/eji.200939399, PubMed 19904767
Distinct infiltration of neutrophils in lesion shoulders in ApoE-/- mice
Am J Pathol, 177 (1), 493-500
DOI 10.2353/ajpath.2010.090480, PubMed 20472897
Identification of a novel KIR3DL1*072 allele by sequence-based typing
Tissue Antigens, 76 (1), 74-5
DOI 10.1111/j.1399-0039.2010.01464.x, PubMed 20210921
Interactions of NK cell receptor KIR3DL1*004 with chaperones and conformation-specific antibody reveal a functional folded state as well as predominant intracellular retention
J Immunol, 186 (1), 62-72
DOI 10.4049/jimmunol.0903657, PubMed 21115737
Publications 2009
KIR acquisition probabilities are independent of self-HLA class I ligands and increase with cellular KIR expression
Blood, 114 (1), 95-104
DOI 10.1182/blood-2008-10-184549, PubMed 19304956
Natural killer cell-mediated lysis of freshly isolated human tumor cells
Int J Cancer, 124 (4), 757-62
DOI 10.1002/ijc.24082, PubMed 19035446
Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cells
J Immunol, 183 (8), 4921-30
DOI 10.4049/jimmunol.0901226, PubMed 19801517
Regulation of interleukin-4 signaling by extracellular reduction of intramolecular disulfides
Biochem Biophys Res Commun, 390 (4), 1272-7
DOI 10.1016/j.bbrc.2009.10.134, PubMed 19878651
T cell infiltrates in the muscles of patients with dermatomyositis and polymyositis are dominated by CD28null T cells
J Immunol, 183 (7), 4792-9
DOI 10.4049/jimmunol.0803688, PubMed 19752224
Education of human natural killer cells by activating killer cell immunoglobulin-like receptors
Blood, 115 (6), 1166-74
DOI 10.1182/blood-2009-09-245746, PubMed 19903900
Spotlight on IL-22-producing NK cell receptor-expressing mucosal lymphocytes
Nat Immunol, 10 (1), 11-2
DOI 10.1038/ni0109-11, PubMed 19088733
Publications 2008
Elevated numbers of Fc gamma RIIIA+ (CD16+) effector CD8 T cells with NK cell-like function in chronic hepatitis C virus infection
J Immunol, 181 (6), 4219-28
DOI 10.4049/jimmunol.181.6.4219, PubMed 18768879
Estimation of the size of the alloreactive NK cell repertoire: studies in individuals homozygous for the group A KIR haplotype
J Immunol, 181 (9), 6010-9
DOI 10.4049/jimmunol.181.9.6010, PubMed 18941190
NK cell-mediated targeting of human cancer and possibilities for new means of immunotherapy
Cancer Immunol Immunother, 57 (10), 1541-52
DOI 10.1007/s00262-008-0492-7, PubMed 18317755
Publications 2007
DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells
Cancer Res, 67 (3), 1317-25
DOI 10.1158/0008-5472.CAN-06-2264, PubMed 17283169
Application of nine-color flow cytometry for detailed studies of the phenotypic complexity and functional heterogeneity of human lymphocyte subsets
J Immunol Methods, 330 (1-2), 64-74
DOI 10.1016/j.jim.2007.10.020, PubMed 18083186
The CD16- CD56(bright) NK cell subset is resistant to reactive oxygen species produced by activated granulocytes and has higher antioxidative capacity than the CD16+ CD56(dim) subset
J Immunol, 179 (7), 4513-9
DOI 10.4049/jimmunol.179.7.4513, PubMed 17878347
IFN-gamma production dominates the early human natural killer cell response to Coxsackievirus infection
Cell Microbiol, 10 (2), 426-36
DOI 10.1111/j.1462-5822.2007.01056.x, PubMed 17961184
Prospects for the use of NK cells in immunotherapy of human cancer
Nat Rev Immunol, 7 (5), 329-39
DOI 10.1038/nri2073, PubMed 17438573
Publications 2006
A short-term dietary supplementation with high doses of vitamin E increases NK cell cytolytic activity in advanced colorectal cancer patients
Cancer Immunol Immunother, 56 (7), 973-84
DOI 10.1007/s00262-006-0261-4, PubMed 17143612
Frequent loss of HLA-A2 expression in metastasizing ovarian carcinomas associated with genomic haplotype loss and HLA-A2-restricted HER-2/neu-specific immunity
Cancer Res, 66 (12), 6387-94
DOI 10.1158/0008-5472.CAN-06-0029, PubMed 16778217
Publications 2005
Escape from immune- and nonimmune-mediated tumor surveillance
Semin Cancer Biol, 16 (1), 16-31
DOI 10.1016/j.semcancer.2005.07.007, PubMed 16140546
KIR-ligand mismatch in allogeneic hematopoietic stem cell transplantation
Mol Immunol, 42 (4), 531-4
DOI 10.1016/j.molimm.2004.07.037, PubMed 15607809
Preferential cell death of CD8+ effector memory (CCR7-CD45RA-) T cells by hydrogen peroxide-induced oxidative stress
J Immunol, 174 (10), 6080-7
DOI 10.4049/jimmunol.174.10.6080, PubMed 15879102
Publications 2004
Effective immunotherapy against cancer: a question of overcoming immune suppression and immune escape?
Cancer Immunol Immunother, 53 (10), 879-92
DOI 10.1007/s00262-004-0577-x, PubMed 15338206
Increased infection-related mortality in KIR-ligand-mismatched unrelated allogeneic hematopoietic stem-cell transplantation
Transplantation, 78 (7), 1081-5
DOI 10.1097/01.tp.0000137103.19717.86, PubMed 15480179
Publications 2002
A short-term dietary supplementation of high doses of vitamin E increases T helper 1 cytokine production in patients with advanced colorectal cancer
Clin Cancer Res, 8 (6), 1772-8
PubMed 12060616
IFN-gamma protects short-term ovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism
J Clin Invest, 110 (10), 1515-23
DOI 10.1172/JCI15564, PubMed 12438449
Publications 2001
The identification of a common pathogen-specific HLA class I A*0201-restricted cytotoxic T cell epitope encoded within the heat shock protein 65
Eur J Immunol, 31 (12), 3602-11
DOI 10.1002/1521-4141(200112)31:12<3602::aid-immu3602>3.0.co;2-l, PubMed 11745380
Inhibition of activated/memory (CD45RO(+)) T cells by oxidative stress associated with block of NF-kappaB activation
J Immunol, 167 (5), 2595-601
DOI 10.4049/jimmunol.167.5.2595, PubMed 11509600
Publications 1999
Identification of new HER2/neu-derived peptide epitopes that can elicit specific CTL against autologous and allogeneic carcinomas and melanomas
J Immunol, 163 (2), 1037-44
PubMed 10395702