Kanutte Huse

  • Senior researcher; PhD
  • +47 22 78 14 27

Room: K03.059


Publications 2024

Chauhan SK, Dunn C, Andresen NK, Røssevold AH, Skorstad G, Sike A, Gilje B, Raj SX, Huse K, Naume B, Kyte JA (2024)
Peripheral immune cells in metastatic breast cancer patients display a systemic immunosuppressed signature consistent with chronic inflammation
NPJ Breast Cancer, 10 (1), 30
DOI 10.1038/s41523-024-00638-2, PubMed 38653982

Meriranta L, Sorri S, Huse K, Liu X, Spasevska I, Zafar S, Chowdhury I, Dufva O, Sahlberg E, Tandaric L, Karjalainen-Lindsberg ML, Hyytiainen M, Varjosalo M, Myklebust JH, Leppa S (2024)
Disruption of KLHL6 Fuels Oncogenic Antigen Receptor Signaling in B-cell Lymphoma
Blood Cancer Discov (in press)
DOI 10.1158/2643-3230.BCD-23-0182, PubMed 38630892

Otterlei Fjørtoft M, Huse K, Rye IH (2024)
The Tumor Immune Microenvironment in Breast Cancer Progression
Acta Oncol, 63, 359-367
DOI 10.2340/1651-226X.2024.33008, PubMed 38779867

Publications 2023

Spasevska I, Sharma A, Steen CB, Josefsson SE, Blaker YN, Kolstad A, Rustad EH, Meyer S, Isaksen K, Chellappa S, Kushekhar K, Beiske K, Førsund MS, Spetalen S, Holte H, Østenstad B, Brodtkorb M, Kimby E, Olweus J, Taskén K, Newman AM, Lorenz S, Smeland EB, Alizadeh AA, Huse K et al. (2023)
Diversity of intratumoral regulatory T cells in B-cell non-Hodgkin lymphoma
Blood Adv, 7 (23), 7216-7230
DOI 10.1182/bloodadvances.2023010158, PubMed 37695745

Publications 2022

Huse K, Bai B, Hilden VI, Bollum LK, Våtsveen TK, Munthe LA, Smeland EB, Irish JM, Wälchli S, Myklebust JH (2022)
Mechanism of CD79A and CD79B Support for IgM+ B Cell Fitness through B Cell Receptor Surface Expression
J Immunol, 209 (10), 2042-2053
DOI 10.4049/jimmunol.2200144, PubMed 36426942

Publications 2021

Rye IH, Huse K, Josefsson SE, Kildal W, Danielsen HE, Schlichting E, Garred Ø, Riis ML, Osbreac, Lingjaerde OC, Myklebust JH, Russnes HG (2021)
Breast cancer metastasis: immune profiling of lymph nodes reveals exhaustion of effector T cells and immunosuppression
Mol Oncol, 16 (1), 88-103
DOI 10.1002/1878-0261.13047, PubMed 34165864

Publications 2020

Rein ID, Notø HØ, Bostad M, Huse K, Stokke T (2020)
Cell Cycle Analysis and Relevance for Single-Cell Gating in Mass Cytometry
Cytometry A, 97 (8), 832-844
DOI 10.1002/cyto.a.23960, PubMed 31943748

Sonnet F, Namork E, Stylianou E, Gaare-Olstad I, Huse K, Andorf S, Mjaaland S, Dirven H, Nygaard U (2020)
Reduced polyfunctional T cells and increased cellular activation markers in adult allergy patients reporting adverse reactions to food
BMC Immunol, 21 (1), 43
DOI 10.1186/s12865-020-00373-w, PubMed 32698761

Publications 2019

Huse K (2019)
Expanding the Clinical Cytometry Toolbox-Receptor Occupancy by Mass Cytometry
Cytometry A, 95 (10), 1046-1048
DOI 10.1002/cyto.a.23784, PubMed 31046178

Huse K, Wogsland CE, Polikowsky HG, Diggins KE, Smeland EB, Myklebust JH, Irish JM (2019)
Human Germinal Center B Cells Differ from Naïve and Memory B Cells in CD40 Expression and CD40L-Induced Signaling Response
Cytometry A, 95 (4), 442-449
DOI 10.1002/cyto.a.23737, PubMed 30838773

Josefsson SE, Beiske K, Blaker YN, Førsund MS, Holte H, Østenstad B, Kimby E, Köksal H, Wälchli S, Bai B, Smeland EB, Levy R, Kolstad A, Huse K, Myklebust JH (2019)
TIGIT and PD-1 Mark Intratumoral T Cells with Reduced Effector Function in B-cell Non-Hodgkin Lymphoma
Cancer Immunol Res, 7 (3), 355-362
DOI 10.1158/2326-6066.CIR-18-0351, PubMed 30659053

Köksal H, Dillard P, Josefsson SE, Maggadottir SM, Pollmann S, Fåne A, Blaker YN, Beiske K, Huse K, Kolstad A, Holte H, Kvalheim G, Smeland EB, Myklebust JH, Inderberg EM, Wälchli S (2019)
Preclinical development of CD37CAR T-cell therapy for treatment of B-cell lymphoma
Blood Adv, 3 (8), 1230-1243
DOI 10.1182/bloodadvances.2018029678, PubMed 30979721

Publications 2017

Bollum LK, Huse K, Oksvold MP, Bai B, Hilden VI, Forfang L, Yoon SO, Wälchli S, Smeland EB, Myklebust JH (2017)
BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-β receptor type I ALK5
PLoS One, 12 (5), e0177188
DOI 10.1371/journal.pone.0177188, PubMed 28489883

Josefsson SE, Huse K, Kolstad A, Beiske K, Pende D, Steen CB, Inderberg EM, Lingjærde OC, Østenstad B, Smeland EB, Levy R, Irish JM, Myklebust JH (2017)
T Cells Expressing Checkpoint Receptor TIGIT Are Enriched in Follicular Lymphoma Tumors and Characterized by Reversible Suppression of T-cell Receptor Signaling
Clin Cancer Res, 24 (4), 870-881
DOI 10.1158/1078-0432.CCR-17-2337, PubMed 29217528

Wogsland CE, Greenplate AR, Kolstad A, Myklebust JH, Irish JM, Huse K (2017)
Mass Cytometry of Follicular Lymphoma Tumors Reveals Intrinsic Heterogeneity in Proteins Including HLA-DR and a Deficit in Nonmalignant Plasmablast and Germinal Center B-Cell Populations
Cytometry B Clin Cytom, 92 (1), 79-87
DOI 10.1002/cyto.b.21498, PubMed 27933753

Publications 2015

Polikowsky HG, Wogsland CE, Diggins KE, Huse K, Irish JM (2015)
Cutting Edge: Redox Signaling Hypersensitivity Distinguishes Human Germinal Center B Cells
J Immunol, 195 (4), 1364-1367
DOI 10.4049/jimmunol.1500904, PubMed 26157177

Publications 2013

Brodtkorb M, Lingjærde OC, Huse K, Trøen G, Hystad M, Hilden VI, Myklebust JH, Leich E, Rosenwald A, Delabie J, Holte H, Smeland EB (2013)
Whole-genome integrative analysis reveals expression signatures predicting transformation in follicular lymphoma
Blood, 123 (7), 1051-4
DOI 10.1182/blood-2013-07-512392, PubMed 24357726

Publications 2012

Bakkebø M, Huse K, Hilden VI, Forfang L, Myklebust JH, Smeland EB, Oksvold MP (2012)
SARA is dispensable for functional TGF-β signaling
FEBS Lett, 586 (19), 3367-72
DOI 10.1016/j.febslet.2012.07.027, PubMed 22819827

Huse K, Bakkebø M, Wälchli S, Oksvold MP, Hilden VI, Forfang L, Bredahl ML, Liestøl K, Alizadeh AA, Smeland EB, Myklebust JH (2012)
Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma
PLoS One, 7 (10), e46117
DOI 10.1371/journal.pone.0046117, PubMed 23049692

Publications 2011

Huse K (2011)
The role of bone morphogenetic proteins in normal and malignant lymphocytes
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 1143, 1 b. (flere pag.)
BIBSYS 112899609, ISBN 978-82-8264-027-5

Huse K, Bakkebø M, Oksvold MP, Forfang L, Hilden VI, Stokke T, Smeland EB, Myklebust JH (2011)
Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7
Eur J Immunol, 41 (11), 3135-45
DOI 10.1002/eji.201141558, PubMed 21898381

Publications 2010

Bakkebø M, Huse K, Hilden VI, Smeland EB, Oksvold MP (2010)
TGF-β-induced growth inhibition in B-cell lymphoma correlates with Smad1/5 signalling and constitutively active p38 MAPK
BMC Immunol, 11, 57
DOI 10.1186/1471-2172-11-57, PubMed 21092277

Groth M, Wiegand C, Szafranski K, Huse K, Kramer M, Rosenstiel P, Schreiber S, Norgauer J, Platzer M (2010)
Both copy number and sequence variations affect expression of human DEFB4
Genes Immun, 11 (6), 458-66
DOI 10.1038/gene.2010.19, PubMed 20445567

Publications 2007

Sivertsen EA, Huse K, Hystad ME, Kersten C, Smeland EB, Myklebust JH (2007)
Inhibitory effects and target genes of bone morphogenetic protein 6 in Jurkat TAg cells
Eur J Immunol, 37 (10), 2937-48
DOI 10.1002/eji.200636759, PubMed 17899540

Publications 2006

Winning J, Claus RA, Huse K, Bauer M (2006)
Molecular biology on the ICU. From understanding to treating sepsis
Minerva Anestesiol, 72 (5), 255-67
PubMed 16675935

Zheng W, Rosenstiel P, Huse K, Sina C, Valentonyte R, Mah N, Zeitlmann L, Grosse J, Ruf N, Nürnberg P, Costello CM, Onnie C, Mathew C, Platzer M, Schreiber S, Hampe J (2006)
Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease
Genes Immun, 7 (1), 11-8
DOI 10.1038/sj.gene.6364263, PubMed 16222343

Publications 2005

Moche M, Hui DS, Huse K, Chan KS, Choy DK, Scholz GH, Gosse H, Winkler J, Schauer J, Sack U, Hoheisel G (2005)
[Matrix metalloproteinases and their inhibitors in lung cancer with malignant pleural effusion]
Pneumologie, 59 (8), 523-8
DOI 10.1055/s-2005-870966, PubMed 16110415

Publications 2004

Sinnreich O, Kratzsch J, Reichenbach A, Gläser C, Huse K, Birkenmeier G (2004)
Plasma levels of transforming growth factor-1beta and alpha2-macroglobulin before and after radical prostatectomy: association to clinicopathological parameters
Prostate, 61 (3), 201-8
DOI 10.1002/pros.20062, PubMed 15368477

Publications 2003

Birkenmeier G, Müller R, Huse K, Forberg J, Gläser C, Hedrich H, Nicklisch S, Reichenbach A (2003)
Human alpha2-macroglobulin: genotype-phenotype relation
Exp Neurol, 184 (1), 153-61
DOI 10.1016/s0014-4886(03)00110-9, PubMed 14637088

Publications 2001

Hoheisel G, Sack U, Hui DS, Huse K, Chan KS, Chan KK, Hartwig K, Schuster E, Scholz GH, Schauer J (2001)
Occurrence of matrix metalloproteinases and tissue inhibitors of metalloproteinases in tuberculous pleuritis
Tuberculosis (Edinb), 81 (3), 203-9
DOI 10.1054/tube.2000.0276, PubMed 11466032

Publications 1999

Huse K, Wippich P, Gutknecht D, Aust G, Scholz GH (1999)
Purification of aminophenyl mercuryacetate-activated human matrix metalloproteinase 1 and removal of the organomercurial in a single-step chromatography
Bioseparation, 7 (6), 281-6
DOI 10.1023/a:1008045515149, PubMed 10643638

Publications 1998

Scholz GH, Vieweg S, Leistner S, Seissler J, Scherbaum WA, Huse K (1998)
A simplified procedure for the isolation of immunoglobulins from human serum using a novel type of thiophilic gel at low salt concentration
J Immunol Methods, 219 (1-2), 109-18
DOI 10.1016/s0022-1759(98)00132-x, PubMed 9831392

Scholz GH, Wippich P, Leistner S, Huse K (1998)
Salt-independent binding of antibodies from human serum to thiophilic heterocyclic ligands
J Chromatogr B Biomed Sci Appl, 709 (2), 189-96
DOI 10.1016/s0378-4347(98)00109-1, PubMed 9657215

Publications 1996

Schneider H, Huse K (1996)
Arterial gene therapy
Lancet, 348 (9038), 1380-1; author reply 1381-2
DOI 10.1016/S0140-6736(05)65442-6, PubMed 8918290

Schneider H, Huse K, Birkenmeier G, Otto A, Scholz GH (1996)
Gene transfer mediated by alpha2-macroglobulin
Nucleic Acids Res, 24 (19), 3873-4
DOI 10.1093/nar/24.19.3873, PubMed 8871570

Publications 1992

Hohmann S, Huse K, Valentin E, Mbonyi K, Thevelein JM, Zimmermann FK (1992)
Glucose-induced regulatory defects in the Saccharomyces cerevisiae byp1 growth initiation mutant and identification of MIG1 as a partial suppressor
J Bacteriol, 174 (12), 4183-8
DOI 10.1128/jb.174.12.4183-4188.1992, PubMed 1597433

Publications 1988

Huse K, Jergil B, Schwidop WD, Kopperschläger G (1988)
Evidence for phosphorylation of yeast phosphofructokinase
FEBS Lett, 234 (1), 185-8
DOI 10.1016/0014-5793(88)81330-9, PubMed 2968917

Kriegel T, Huse K, Kopperschläger G (1988)
The use of separated subunits of yeast phosphofructokinase for the isolation of subunit-specific antibodies from polyclonal antisera
Biomed Biochim Acta, 47 (7), 705-11
PubMed 2974282

Publications 1987

Piek J, Adelt T, Huse K, Bock WJ (1987)
[Cerebrospinal fluid and plasma aminograms in patients with primary and secondary tumors of the CNS]
Infusionsther Klin Ernahr, 14 (2), 73-7
PubMed 3610311

Publications 1984

Porstmann B, Porstmann T, Schmechta H, Nugel E, Huse K, Kopperschläger G, Seifert R (1984)
Direct two-site binding enzyme immunoassay for human alpha-1-fetoprotein. Part I: Comparison of different peroxidase-IgG-conjugates and various reaction conditions
Z Med Lab Diagn, 25 (1), 5-13
PubMed 6202071

Publications 1983

Huse K, Himmel M, Birkenmeier G, Bohla M, Kopperschläger G (1983)
A novel purification procedure for human alpha-fetoprotein by application of immobilised Cibacron Blue F3G-A as affinity ligand
Clin Chim Acta, 133 (3), 335-40
DOI 10.1016/0009-8981(83)90280-2, PubMed 6194922

Huse K, Kopperschläger G (1983)
Interactions of antibodies against soluble phosphofructokinase with the soluble and particulate enzymes from yeast
FEBS Lett, 155 (1), 50-4
DOI 10.1016/0014-5793(83)80207-5, PubMed 6220923

Publications 1982

Huse K, Kopperschläger G, Hofmann E (1982)
A new procedure for the purification of proteinase B from baker's yeast and interaction of the purified enzyme with a specific inhibitor
Acta Biol Med Ger, 41 (11), 991-1002
PubMed 6763433

Publications 1981

Huse K, Diening G (1981)
[Anaesthesia and diabetes insipidus. A review (author's transl)]
Anaesthesist, 30 (4), 159-65
PubMed 7018319

Publications 1980

Huse K, Leem W (1980)
[Circulatory changes in neurosurgical patients with intracerebral angiomas in neuroleptanaesthesia (author's transl)]
Anasth Intensivther Notfallmed, 15 (2), 144-51
PubMed 7396101

Huse K, Röhner G (1980)
[Circulatory effects of dihydrazinophthalazine (Nepresol) compared with sodium nitroprusside in controlled hypotension. A study of neurosurgical patients under neuroleptanesthesia]
Anasth Intensivther Notfallmed, 15 (2), 152-8
PubMed 6772047

Huse K, Schäffer R, Fistas G (1980)
[Clinical experiences with diazepam (Valium) - fentanyl combination anesthesia in neurosurgery. A study of circulation and oxygen consumption]
Anasth Intensivther Notfallmed, 15 (2), 135-43
PubMed 6772046

Publications 1979

Diezel W, Meffert H, Günther W, Huse K, Sönnichsen N (1979)
[Exacerbation of systemic lupus erythematosus following UV irradiation--a hypothesis]
Acta Biol Med Ger, 38 (9), 1301-6
PubMed 399148

Huse K, Wiecken H (1979)
[Circulatory changes in the sitting position during neurosurgical anaesthesia (NLA) (author's transl)]
Anaesthesist, 28 (12), 557-63
PubMed 539650

Publications 1978

Huse K, Stahl HJ, Krämer M (1978)
[The effect of buprenorphin on circulation, respiration and the electroencephalogram (a postoperative study of 12 neurosurgical cases) (author's transl)]
Prakt Anaesth, 13 (6), 489-94
PubMed 740629

Publications 1977

Diezel W, Meffert H, Günther W, Huse K, Sönnichsen N (1977)
[Exacerbation of lupus erythematodes visceralis due to UV irradiation. Results and hypothetical aspects]
Dermatol Monatsschr, 163 (4), 290-5
PubMed 881079

Publications 1976

Huse K, Kopperschläger G, Hofmann E (1976)
Differences in the degradation of yeast phosphofructokinase by proteinases A and B from yeast
Biochem J, 155 (3), 721-3
DOI 10.1042/bj1550721, PubMed 133676

Wüst HJ, Huse K, Lennartz H (1976)
[Cardiovascular changes caused by atropine in normo- and hypothermic methoxyflurane anaesthesia (author's transl)]
Anaesthesist, 25 (9), 418-24
PubMed 970597

Publications 1974

Huse K, Hartung E, Nadjmabadi MH (1974)
[The effects of naloxone (Narcan) on circulation and respiration after neurolept anaesthesia for neurosurgical operations (author's transl)]
Anaesthesist, 23 (11), 493-9
PubMed 4458474

Nadjmabadi MH, Huse K (1974)
[Changes of the pah-plasma levels as a guideline for the renal circulation under the influence of various anaesthetic agents (author's transl)]
Anaesthesist, 23 (1), 5-9
PubMed 4458471

Publications 1972

Huse K, Nicola E, Jeuken B (1972)
[Changes of lactic and pyruvic acid levels in the cerebrospinal fluid as possible indicators for central hypoxia. Studies in hydrocephalic children]
Neurochirurgia (Stuttg), 15 (6), 194-200
DOI 10.1055/s-0028-1090542, PubMed 4655985

Huse K, Röhner G (1972)
[Hemodynamic changes in methoxyflurane anesthesia with controlled hypotension and hypothermia for neurosurgery]
Zentralbl Neurochir, 33 (1), 19-33
PubMed 5072148

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