Erlend Bremertun Smeland
- Research director, Professor; MD, PhD
- +47 913 88 199
Publications 2024
Multi-omics profiling of longitudinal samples reveals early genomic changes in follicular lymphoma
Blood Cancer J, 14 (1), 147
DOI 10.1038/s41408-024-01124-5, PubMed 39191762
Publications 2023
Efficient chimeric antigen receptor targeting of a central epitope of CD22
J Biol Chem, 299 (7), 104883
DOI 10.1016/j.jbc.2023.104883, PubMed 37269947
The Geriatric Prognostic Index: a clinical prediction model for survival of older diffuse large B-cell lymphoma patients treated with standard immunochemotherapy
Haematologica, 108 (9), 2454-2466
DOI 10.3324/haematol.2022.282289, PubMed 36861406
Diversity of intratumoral regulatory T cells in B-cell non-Hodgkin lymphoma
Blood Adv, 7 (23), 7216-7230
DOI 10.1182/bloodadvances.2023010158, PubMed 37695745
Publications 2022
Mechanism of CD79A and CD79B Support for IgM+ B Cell Fitness through B Cell Receptor Surface Expression
J Immunol, 209 (10), 2042-2053
DOI 10.4049/jimmunol.2200144, PubMed 36426942
Publications 2021
A simplified frailty score predicts survival and can aid treatment-intensity decisions in older patients with DLBCL
Blood Adv, 5 (22), 4771-4782
DOI 10.1182/bloodadvances.2021004777, PubMed 34543384
Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma
Sci Rep, 11 (1), 6317
DOI 10.1038/s41598-021-85613-8, PubMed 33737576
MAPK and JAK-STAT pathways dysregulation in plasmablastic lymphoma
Haematologica, 106 (10), 2682-2693
DOI 10.3324/haematol.2020.271957, PubMed 33951889
Publications 2020
The DLBCL90 gene-expression assay identifies double-hit lymphomas with high sensitivity in patients from two phase II clinical trials with high-risk diffuse large B-cell lymphoma
EJHaem, 2 (1), 104-108
DOI 10.1002/jha2.109, PubMed 35846101
Combinatorial CAR design improves target restriction
J Biol Chem, 296, 100116
DOI 10.1074/jbc.RA120.016234, PubMed 33234592
Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series
Blood Adv, 4 (9), 1859-1866
DOI 10.1182/bloodadvances.2019001325, PubMed 32374878
Publications 2019
Human Germinal Center B Cells Differ from Naïve and Memory B Cells in CD40 Expression and CD40L-Induced Signaling Response
Cytometry A, 95 (4), 442-449
DOI 10.1002/cyto.a.23737, PubMed 30838773
TIGIT and PD-1 Mark Intratumoral T Cells with Reduced Effector Function in B-cell Non-Hodgkin Lymphoma
Cancer Immunol Res, 7 (3), 355-362
DOI 10.1158/2326-6066.CIR-18-0351, PubMed 30659053
Preclinical development of CD37CAR T-cell therapy for treatment of B-cell lymphoma
Blood Adv, 3 (8), 1230-1243
DOI 10.1182/bloodadvances.2018029678, PubMed 30979721
A clinico-molecular predictor identifies follicular lymphoma patients at risk of early transformation after first-line immunotherapy
Haematologica, 104 (10), e460-e464
DOI 10.3324/haematol.2018.209080, PubMed 30846496
Publications 2018
The MCL35 gene expression proliferation assay predicts high-risk MCL patients in a Norwegian cohort of younger patients given intensive first line therapy
Br J Haematol, 183 (2), 225-234
DOI 10.1111/bjh.15518, PubMed 30080252
Molecular classification of primary mediastinal large B-cell lymphoma using routinely available tissue specimens
Blood, 132 (22), 2401-2405
DOI 10.1182/blood-2018-05-851154, PubMed 30257882
Artesunate shows potent anti-tumor activity in B-cell lymphoma
J Hematol Oncol, 11 (1), 23
DOI 10.1186/s13045-018-0561-0, PubMed 29458389
Publications 2017
BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-β receptor type I ALK5
PLoS One, 12 (5), e0177188
DOI 10.1371/journal.pone.0177188, PubMed 28489883
T Cells Expressing Checkpoint Receptor TIGIT Are Enriched in Follicular Lymphoma Tumors and Characterized by Reversible Suppression of T-cell Receptor Signaling
Clin Cancer Res, 24 (4), 870-881
DOI 10.1158/1078-0432.CCR-17-2337, PubMed 29217528
The management and survival outcomes of nasopharyngeal cancer in the Nordic countries
Acta Oncol, 57 (4), 557-560
DOI 10.1080/0284186X.2017.1408961, PubMed 29202641
New Molecular Assay for the Proliferation Signature in Mantle Cell Lymphoma Applicable to Formalin-Fixed Paraffin-Embedded Biopsies
J Clin Oncol, 35 (15), 1668-1677
DOI 10.1200/JCO.2016.70.7901, PubMed 28291392
Publications 2016
The tumour microenvironment influences survival and time to transformation in follicular lymphoma in the rituximab era
Br J Haematol, 175 (1), 102-14
DOI 10.1111/bjh.14201, PubMed 27341313
Publications 2015
Computerized image analysis of the Ki-67 proliferation index in mantle cell lymphoma
Histopathology, 67 (1), 62-9
DOI 10.1111/his.12624, PubMed 25431344
Primary diffuse large B-cell lymphoma associated with clonally-related monoclonal B lymphocytosis indicates a common precursor cell
Haematologica, 100 (10), e415-8
DOI 10.3324/haematol.2015.126656, PubMed 26001788
The targeting of human and mouse B lymphocytes by dasatinib
Exp Hematol, 43 (5), 352-363.e4
DOI 10.1016/j.exphem.2015.01.008, PubMed 25641047
Publications 2014
A gene panel, including LRP12, is frequently hypermethylated in major types of B-cell lymphoma
PLoS One, 9 (9), e104249
DOI 10.1371/journal.pone.0104249, PubMed 25226156
High dose chemotherapy with autologous stem cell transplant for patients with transformed B-cell non-Hodgkin lymphoma in the rituximab era
Leuk Lymphoma, 55 (10), 2319-27
DOI 10.3109/10428194.2013.871632, PubMed 24432894
Combining MYC, BCL2 and TP53 gene and protein expression alterations improves risk stratification in diffuse large B-cell lymphoma
Leuk Lymphoma, 56 (6), 1742-9
DOI 10.3109/10428194.2014.970550, PubMed 25284491
Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma
Nature, 516 (7530), 254-8
DOI 10.1038/nature13765, PubMed 25274307
Expression of B-cell surface antigens in subpopulations of exosomes released from B-cell lymphoma cells
Clin Ther, 36 (6), 847-862.e1
DOI 10.1016/j.clinthera.2014.05.010, PubMed 24952935
Prognostic influence of macrophages in patients with diffuse large B-cell lymphoma: a correlative study from a Nordic phase II trial
Haematologica, 100 (2), 238-45
DOI 10.3324/haematol.2014.113472, PubMed 25381134
Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue
Blood, 123 (8), 1214-7
DOI 10.1182/blood-2013-11-536433, PubMed 24398326
Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms
Cancer Discov, 4 (4), 480-93
DOI 10.1158/2159-8290.CD-13-0915, PubMed 24491438
Publications 2013
Identification of highly methylated genes across various types of B-cell non-hodgkin lymphoma
PLoS One, 8 (11), e79602
DOI 10.1371/journal.pone.0079602, PubMed 24260260
Colorectal cancer DNA methylation marker panel validated with high performance in Non-Hodgkin lymphoma
Epigenetics, 9 (3), 428-36
DOI 10.4161/epi.27554, PubMed 24362313
Whole-genome integrative analysis reveals expression signatures predicting transformation in follicular lymphoma
Blood, 123 (7), 1051-4
DOI 10.1182/blood-2013-07-512392, PubMed 24357726
EZH2 mutations are frequent and represent an early event in follicular lymphoma
Blood, 122 (18), 3165-8
DOI 10.1182/blood-2013-04-496893, PubMed 24052547
Karyotyping of diffuse large B-cell lymphomas: loss of 17p is associated with poor patient outcome
Eur J Haematol, 91 (4), 332-8
DOI 10.1111/ejh.12171, PubMed 23859481
Higher World Health Organization grades of follicular lymphoma correlate with better outcome in two Nordic Lymphoma Group trials of rituximab without chemotherapy
Leuk Lymphoma, 55 (2), 288-95
DOI 10.3109/10428194.2013.802778, PubMed 23662992
Influence of polymorphisms in genes encoding immunoregulatory proteins and metabolizing enzymes on susceptibility and outcome in patients with diffuse large B-cell lymphoma treated with rituximab
Leuk Lymphoma, 54 (10), 2205-14
DOI 10.3109/10428194.2013.774392, PubMed 23391141
Publications 2012
SARA is dispensable for functional TGF-β signaling
FEBS Lett, 586 (19), 3367-72
DOI 10.1016/j.febslet.2012.07.027, PubMed 22819827
Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma
PLoS One, 7 (10), e46117
DOI 10.1371/journal.pone.0046117, PubMed 23049692
Effect of cycloheximide on epidermal growth factor receptor trafficking and signaling
FEBS Lett, 586 (20), 3575-81
DOI 10.1016/j.febslet.2012.08.022, PubMed 22971756
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics
Nature, 490 (7418), 116-20
DOI 10.1038/nature11378, PubMed 22885699
Polymorphisms in genes encoding interleukin-10 and drug metabolizing enzymes GSTP1, GSTT1, GSTA1 and UGT1A1 influence risk and outcome in Hodgkin lymphoma
Leuk Lymphoma, 53 (10), 1934-44
DOI 10.3109/10428194.2012.682307, PubMed 22475179
Publications 2011
Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7
Eur J Immunol, 41 (11), 3135-45
DOI 10.1002/eji.201141558, PubMed 21898381
Side population cells in highly enriched CD34-positive cells from peripheral blood progenitor cells identify an immature subtype of hematopoietic progenitor cells but do not predict time to engraftment in patients treated with high-dose therapy
Eur J Haematol, 87 (6), 494-502
DOI 10.1111/j.1600-0609.2011.01681.x, PubMed 21752097
LMO2 expression reflects the different stages of blast maturation and genetic features in B-cell acute lymphoblastic leukemia and predicts clinical outcome
Haematologica, 96 (7), 980-6
DOI 10.3324/haematol.2011.040568, PubMed 21459790
Clinical significance of the WHO grades of follicular lymphoma in a population-based cohort of 505 patients with long follow-up times
Br J Haematol, 156 (2), 225-33
DOI 10.1111/j.1365-2141.2011.08942.x, PubMed 22126847
Publications 2010
TGF-β-induced growth inhibition in B-cell lymphoma correlates with Smad1/5 signalling and constitutively active p38 MAPK
BMC Immunol, 11, 57
DOI 10.1186/1471-2172-11-57, PubMed 21092277
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
Nature, 463 (7277), 88-92
DOI 10.1038/nature08638, PubMed 20054396
Genomic alterations reveal potential for higher grade transformation in follicular lymphoma and confirm parallel evolution of tumor cell clones
Blood, 116 (9), 1489-97
DOI 10.1182/blood-2010-03-272278, PubMed 20505157
Oncogenically active MYD88 mutations in human lymphoma
Nature, 470 (7332), 115-9
DOI 10.1038/nature09671, PubMed 21179087
Cooperative epigenetic modulation by cancer amplicon genes
Cancer Cell, 18 (6), 590-605
DOI 10.1016/j.ccr.2010.11.013, PubMed 21156283
[Close cooperation, but not oversteering]
Tidsskr Nor Laegeforen, 130 (6), 590-1
DOI 10.4045/tidsskr.10.0153, PubMed 20348990
[Leadership and academic competence]
Tidsskr Nor Laegeforen, 130 (6), 591
DOI 10.4045/tidsskr.10.0217, PubMed 20348994
Publications 2009
[Molecular diagnosis of malignant lymphomas]
Tidsskr Nor Laegeforen, 129 (22), 2352-6
DOI 10.4045/tidsskr.09.0704, PubMed 19935935
Array-based DNA methylation profiling in follicular lymphoma
Leukemia, 23 (10), 1858-66
DOI 10.1038/leu.2009.114, PubMed 19587707
Publications 2008
Oncogenic CARD11 mutations in human diffuse large B cell lymphoma
Science, 319 (5870), 1676-9
DOI 10.1126/science.1153629, PubMed 18323416
Stromal gene signatures in large-B-cell lymphomas
N Engl J Med, 359 (22), 2313-23
DOI 10.1056/NEJMoa0802885, PubMed 19038878
Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways
Proc Natl Acad Sci U S A, 105 (36), 13520-5
DOI 10.1073/pnas.0804295105, PubMed 18765795
The presence of TP53 mutation at diagnosis of follicular lymphoma identifies a high-risk group of patients with shortened time to disease progression and poorer overall survival
Blood, 112 (8), 3126-9
DOI 10.1182/blood-2008-05-154013, PubMed 18628487
Publications 2007
Characterization of early stages of human B cell development by gene expression profiling
J Immunol, 179 (6), 3662-71
DOI 10.4049/jimmunol.179.6.3662, PubMed 17785802
Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell lymphoma
J Exp Med, 204 (3), 633-43
DOI 10.1084/jem.20062041, PubMed 17353367
Inhibitory effects and target genes of bone morphogenetic protein 6 in Jurkat TAg cells
Eur J Immunol, 37 (10), 2937-48
DOI 10.1002/eji.200636759, PubMed 17899540
Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival
Blood, 109 (11), 4599-606
DOI 10.1182/blood-2006-08-039859, PubMed 17299095
Publications 2006
Molecular diagnosis of Burkitt's lymphoma
N Engl J Med, 354 (23), 2431-42
DOI 10.1056/NEJMoa055759, PubMed 16760443
BMP-6 inhibits human bone marrow B lymphopoiesis--upregulation of Id1 and Id3
Exp Hematol, 34 (1), 72-81
DOI 10.1016/j.exphem.2005.09.010, PubMed 16413393
Gain of chromosome 6p is an infrequent cause of increased PIM1 expression in B-cell non-Hodgkin's lymphomas
Leukemia, 20 (3), 539-42
DOI 10.1038/sj.leu.2404094, PubMed 16437153
PI3K/Akt-dependent Epo-induced signalling and target genes in human early erythroid progenitor cells
Br J Haematol, 135 (1), 117-28
DOI 10.1111/j.1365-2141.2006.06252.x, PubMed 16965383
Publications 2005
Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction
Blood, 106 (9), 3183-90
DOI 10.1182/blood-2005-04-1399, PubMed 16046532
BMP-6 inhibits growth of mature human B cells; induction of Smad phosphorylation and upregulation of Id1
BMC Immunol, 6, 9
DOI 10.1186/1471-2172-6-9, PubMed 15877825
PU.1 protein expression has a positive linear association with protein expression of germinal centre B cell genes including BCL-6, CD10, CD20 and CD22: identification of PU.1 putative binding sites in the BCL-6 promotor
J Pathol, 206 (3), 312-9
DOI 10.1002/path.1777, PubMed 15892171
Publications 2004
Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells
N Engl J Med, 351 (21), 2159-69
DOI 10.1056/NEJMoa041869, PubMed 15548776
Serological cloning of cancer/testis antigens expressed in prostate cancer using cDNA phage surface display
Cancer Immunol Immunother, 53 (5), 431-8
DOI 10.1007/s00262-003-0458-8, PubMed 14747957
NY-ESO-1 protein expression and humoral immune responses in prostate cancer
Prostate, 59 (4), 440-7
DOI 10.1002/pros.20025, PubMed 15065093
Analysis of the autoantibody repertoire in Burkitt's lymphoma patients: frequent response against the transcription factor ATF-2
Cancer Immunol Immunother, 53 (12), 1119-26
DOI 10.1007/s00262-004-0558-0, PubMed 15185015
Publications 2003
Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma
J Exp Med, 198 (6), 851-62
DOI 10.1084/jem.20031074, PubMed 12975453
The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma
Cancer Cell, 3 (2), 185-97
DOI 10.1016/s1535-6108(03)00028-x, PubMed 12620412
Publications 2002
Activation of phosphatidylinositol 3-kinase is important for erythropoietin-induced erythropoiesis from CD34(+) hematopoietic progenitor cells
Exp Hematol, 30 (9), 990-1000
DOI 10.1016/s0301-472x(02)00868-8, PubMed 12225790
The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma
N Engl J Med, 346 (25), 1937-47
DOI 10.1056/NEJMoa012914, PubMed 12075054
Clustering of the SOM easily reveals distinct gene expression patterns: results of a reanalysis of lymphoma study
BMC Bioinformatics, 3, 36
DOI 10.1186/1471-2105-3-36, PubMed 12445336
Publications 2001
High-dose therapy in patients with Hodgkin's disease: the use of selected CD34(+) cells is as safe as unmanipulated peripheral blood progenitor cells
Bone Marrow Transplant, 28 (9), 849-57
DOI 10.1038/sj.bmt.1703244, PubMed 11781645
[Gene therapy in cancer]
Tidsskr Nor Laegeforen, 121 (4), 482-8
PubMed 11255868
[Gene therapy--status and recommendations in Norwegian health care system]
Tidsskr Nor Laegeforen, 121 (3), 343-8
PubMed 11242880
Loss of chromosome 11q21-23.1 and 17p and gain of chromosome 6p are independent prognostic indicators in B-cell non-Hodgkin's lymphoma
Br J Cancer, 85 (12), 1900-13
DOI 10.1054/bjoc.2001.2164, PubMed 11747333
Publications 2000
Identification of nucleolar protein No55 as a tumour-associated autoantigen in patients with prostate cancer
Br J Cancer, 83 (6), 743-9
DOI 10.1054/bjoc.2000.1365, PubMed 10952778
Differential expression of bcl-2 homologs in human CD34(+) hematopoietic progenitor cells induced to differentiate into erythroid or granulocytic cells
Stem Cells, 18 (4), 261-72
DOI 10.1634/stemcells.18-4-261, PubMed 10924092
Protein kinase C-alpha isoform is involved in erythropoietin-induced erythroid differentiation of CD34(+) progenitor cells from human bone marrow
Blood, 95 (2), 510-8
DOI 10.1182/blood.V95.2.510, PubMed 10627456
cAMP-mediated growth inhibition of lymphoid cells in G1: rapid down-regulation of cyclin D3 at the level of translation
Eur J Immunol, 30 (6), 1757-68
DOI 10.1002/1521-4141(200006)30:6<1757::AID-IMMU1757>3.0.CO;2-N, PubMed 10898514
Genterapi: status og fremtidige muligheter innen klinisk medisin
In SMM-rapport, Senteret, Oslo, 2000:1, 124 s.
BIBSYS 000268178, ISBN 82-14-01814-5
Gene therapy: status and potential in clinical medicine
In SMM-rapport, Senteret, Oslo, nr 7/2000, 120 s.
BIBSYS 010526498, ISBN 82-14-02179-0
Oncogenic aberrations in the p53 pathway are associated with a high S phase fraction and poor patient survival in B-cell Non-Hodgkin's lymphoma
Int J Cancer, 89 (4), 313-24
DOI 10.1002/1097-0215(20000720)89:4<313::aid-ijc1>3.0.co;2-d, PubMed 10956404
A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes
Blood, 95 (1), 221-30
DOI 10.1182/blood.V95.1.221.001k01_221_230, PubMed 10607706
Publications 1999
Evaluation of lymphoid cell populations in cytology specimens using flow cytometry and polymerase chain reaction
Diagn Mol Pathol, 8 (4), 183-8
DOI 10.1097/00019606-199912000-00003, PubMed 10617274
Prognostic value of lymphoma-specific S-phase fraction compared with that of other cell proliferation markers
Acta Oncol, 38 (4), 495-503
DOI 10.1080/028418699432040, PubMed 10418718
Retinoic acid induces apoptosis of human CD34+ hematopoietic progenitor cells: involvement of retinoic acid receptors and retinoid X receptors depends on lineage commitment of the hematopoietic progenitor cells
Exp Hematol, 27 (4), 642-53
DOI 10.1016/s0301-472x(98)00073-3, PubMed 10210322
Fas ligand promotes cell survival of immature human bone marrow CD34+CD38- hematopoietic progenitor cells by suppressing apoptosis
Exp Hematol, 27 (9), 1451-9
DOI 10.1016/s0301-472x(99)00073-9, PubMed 10480436
Activation of the cAMP signaling pathway increases apoptosis in human B-precursor cells and is associated with downregulation of Mcl-1 expression
J Cell Physiol, 180 (1), 71-80
DOI 10.1002/(SICI)1097-4652(199907)180:1<71::AID-JCP8>3.0.CO;2-N, PubMed 10362019
Lovastatin inhibits G1/S transition of normal human B-lymphocytes independent of apoptosis
Exp Cell Res, 252 (1), 144-53
DOI 10.1006/excr.1999.4608, PubMed 10502407
[University function at the central hospital in Akershus]
Tidsskr Nor Laegeforen, 119 (11), 1647
PubMed 10385812
Publications 1998
Combination chemotherapy with mitoguazon, ifosfamide, MTX, etoposide (MIME) and G-CSF can efficiently mobilize PBPC in patients with Hodgkin's and non-Hodgkin's lymphoma
Bone Marrow Transplant, 21 (9), 873-8
DOI 10.1038/sj.bmt.1701192, PubMed 9613778
[Molecular genetic diagnosis of leukemias and lymphomas]
Tidsskr Nor Laegeforen, 118 (16), 2511-8
PubMed 9667131
[Chronic lymphatic leukemia. Immunophenotyping as an aid to correct diagnosis]
Tidsskr Nor Laegeforen, 118 (2), 233-7
PubMed 9485618
RAR-, not RXR, ligands inhibit cell activation and prevent apoptosis in B-lymphocytes
J Cell Physiol, 175 (1), 68-77
DOI 10.1002/(SICI)1097-4652(199804)175:1<68::AID-JCP8>3.0.CO;2-A, PubMed 9491782
Proliferation and apoptosis in malignant and normal cells in B-cell non-Hodgkin's lymphomas
Br J Cancer, 77 (11), 1832-8
DOI 10.1038/bjc.1998.304, PubMed 9667654
Tumour cell proliferation, but not apoptosis, predicts survival in B-cell non-Hodgkin's lymphomas
Br J Cancer, 77 (11), 1839-41
DOI 10.1038/bjc.1998.305, PubMed 9667655
Publications 1997
Involvement of ICE (Caspase) family in gamma-radiation-induced apoptosis of normal B lymphocytes
Scand J Immunol, 46 (6), 601-8
DOI 10.1046/j.1365-3083.1997.d01-173.x, PubMed 9420624
A novel putative G-protein-coupled receptor expressed in lung, heart and lymphoid tissue
FEBS Lett, 407 (1), 59-62
DOI 10.1016/s0014-5793(97)00278-0, PubMed 9141481
Interleukin-13 in combination with CD40 ligand potently inhibits apoptosis in human B lymphocytes: upregulation of Bcl-xL and Mcl-1
Blood, 89 (12), 4415-24
PubMed 9192766
CDw78--a determinant on a major histocompatibility complex class II subpopulation that can be induced to associate with the cytoskeleton
Eur J Immunol, 27 (12), 3206-13
DOI 10.1002/eji.1830271218, PubMed 9464807
[Changing physician's role]
Tidsskr Nor Laegeforen, 117 (29), 4290
PubMed 9441481
Characterization, expression and chromosomal localization of a human gene homologous to the mouse Lsc oncogene, with strongest expression in hematopoetic tissues
Oncogene, 14 (14), 1747-52
DOI 10.1038/sj.onc.1200994, PubMed 9135076
Publications 1996
[High-dose therapy of cancer with CD34 positive cells as stem cell support]
Tidsskr Nor Laegeforen, 116 (21), 2542-6
PubMed 8928121
Purging of tumor cells from leukapheresis products: experimental and clinical aspects
J Hematother, 5 (4), 427-36
DOI 10.1089/scd.1.1996.5.427, PubMed 8877718
Cyclic AMP-dependent protein kinase (cAK) in human B cells: co-localization of type I cAK (RI alpha 2 C2) with the antigen receptor during anti-immunoglobulin-induced B cell activation
Eur J Immunol, 26 (6), 1290-6
DOI 10.1002/eji.1830260617, PubMed 8647207
Expression of the Bcl-2 homologue Mcl-1 correlates with survival of peripheral blood B lymphocytes
Cancer Res, 56 (1), 40-3
PubMed 8548771
The RAR-RXR as well as the RXR-RXR pathway is involved in signaling growth inhibition of human CD34+ erythroid progenitor cells
Blood, 87 (5), 1728-36
PubMed 8634418
Solid-phase method for differential display of genes expressed in hematopoietic stem cells
Biotechniques, 21 (1), 114-21
DOI 10.2144/96211rr02, PubMed 8816245
High-dose 7-hydromethotrexate: acute toxicity and lethality in a rat model
Cancer Chemother Pharmacol, 37 (5), 415-22
DOI 10.1007/s002800050406, PubMed 8599863
Publications 1995
Semiquantitative polymerase chain reaction for t(14;18) in follicular lymphomas: a colorimetric approach
Lab Invest, 72 (4), 411-8
PubMed 7723279
All-trans- and 9-cis-retinoic acid inhibit growth of normal human and murine B cell precursors
J Immunol, 155 (1), 58-65
PubMed 7602122
TGF-beta 1 and cyclic AMP promote apoptosis in resting human B lymphocytes
J Immunol, 154 (4), 1634-43
PubMed 7836748
[Physicians liable for military service for sale]
Tidsskr Nor Laegeforen, 115 (24), 3072
PubMed 7570542
The effect of calcium channel blockers and calcium on methotrexate accumulation in rat hepatocytes
Anticancer Res, 15 (4), 1221-5
PubMed 7654001
Perturbation of methotrexate transport by verapamil, vinblastine, taurocholate and bromosulfophthalein in rat hepatocytes
Anticancer Res, 15 (1), 45-50
PubMed 7733639
Characterization of a promoter region supporting transcription of a novel human beta-galactoside alpha-2,6-sialyltransferase transcript in HepG2 cells
Biochim Biophys Acta, 1261 (1), 166-9
DOI 10.1016/0167-4781(94)00250-7, PubMed 7893756
Publications 1994
Retinoblastoma protein is rapidly dephosphorylated by elevated cyclic adenosine monophosphate levels in human B-lymphoid cells
Cancer Res, 54 (8), 2245-50
PubMed 8174134
Role of the 75-kDa tumor necrosis factor receptor: inhibition of early hematopoiesis
Proc Natl Acad Sci U S A, 91 (22), 10695-9
DOI 10.1073/pnas.91.22.10695, PubMed 7524102
All-trans- and 9-cis-retinoic acid: potent direct inhibitors of primitive murine hematopoietic progenitors in vitro
J Exp Med, 179 (5), 1665-70
DOI 10.1084/jem.179.5.1665, PubMed 8163945
Autologous bone marrow transplantation of non-Hodgkin's lymphoma patients with marrow purged using immunomagnetic beads
Prog Clin Biol Res, 389, 133-8
PubMed 7700895
[Bone marrow transplantation--a constantly developing procedure--requiring updating]
Tidsskr Nor Laegeforen, 114 (3), 302-3
PubMed 8191422
Cross-linking of CD53 promotes activation of resting human B lymphocytes
J Immunol, 153 (11), 4997-5007
PubMed 7963560
Bifunctional effects of tumor necrosis factor alpha (TNF alpha) on the growth of mature and primitive human hematopoietic progenitor cells: involvement of p55 and p75 TNF receptors
Blood, 83 (11), 3152-9
PubMed 7514902
Functional differences between CD38- and DR- subfractions of CD34+ bone marrow cells
Blood, 84 (5), 1473-81
PubMed 7520773
Tumor necrosis factor-alpha inhibits stem cell factor-induced proliferation of human bone marrow progenitor cells in vitro. Role of p55 and p75 tumor necrosis factor receptors
J Clin Invest, 94 (1), 165-72
DOI 10.1172/JCI117303, PubMed 7518828
Renal and hepatic toxicity after high-dose 7-hydroxymethotrexate in the rat
Cancer Chemother Pharmacol, 34 (2), 119-24
DOI 10.1007/BF00685928, PubMed 8194163
All-trans retinoic acid directly inhibits granulocyte colony-stimulating factor-induced proliferation of CD34+ human hematopoietic progenitor cells
Blood, 84 (9), 2940-5
DOI 10.1182/blood.V84.9.2940.bloodjournal8492940, PubMed 7524761
A simple subtraction method for the isolation of cell-specific genes using magnetic monodisperse polymer particles
Biotechniques, 16 (4), 716-21
PubMed 8024795
Tissue specific expression and cDNA structure of a human transcript encoding a nucleic acid binding [oligo(dC)] protein related to the pre-mRNA binding protein K
Nucleic Acids Res, 22 (6), 959-64
DOI 10.1093/nar/22.6.959, PubMed 8152927
Publications 1993
Constitutive expression of c-myc does not relieve cAMP-mediated growth arrest in human lymphoid Reh cells
J Cell Physiol, 157 (1), 61-9
DOI 10.1002/jcp.1041570108, PubMed 8408242
Expression of CD18 (integrin beta 2 chain) correlates with prognosis in malignant B cell lymphomas
Br J Haematol, 83 (3), 392-8
DOI 10.1111/j.1365-2141.1993.tb04662.x, PubMed 8097923
Cytotoxic lymphocyte maturation factor (interleukin 12) is a synergistic growth factor for hematopoietic stem cells
J Exp Med, 178 (2), 413-8
DOI 10.1084/jem.178.2.413, PubMed 7688022
Leukemic blasts with markers of four cell lineages in Down's syndrome ("megakaryoblastic leukemia")
Med Pediatr Oncol, 21 (4), 254-8
DOI 10.1002/mpo.2950210404, PubMed 8469219
Interactions of vinblastine and vincristine with methotrexate transport in isolated rat hepatocytes
Cancer Chemother Pharmacol, 32 (3), 209-14
DOI 10.1007/BF00685837, PubMed 8500226
Cell-specific expression of human beta-galactoside alpha 2,6-sialyltransferase transcripts differing in the 5' untranslated region
Eur J Biochem, 213 (1), 467-75
DOI 10.1111/j.1432-1033.1993.tb17783.x, PubMed 8477718
Publications 1992
Vitamin A is a key regulator for cell growth, cytokine production, and differentiation in normal B cells
J Biol Chem, 267 (33), 23988-92
PubMed 1429735
Cell cycle-dependent regulation of CDw75 (beta-galactoside alpha-2,6-sialyltransferase) on human B lymphocytes
Eur J Immunol, 22 (5), 1149-55
DOI 10.1002/eji.1830220507, PubMed 1577059
A new method for detachment of Dynabeads from positively selected B lymphocytes
J Immunol Methods, 146 (2), 195-202
DOI 10.1016/0022-1759(92)90228-l, PubMed 1371532
[Programmed cell death--significance for cancer etiology and treatment]
Tidsskr Nor Laegeforen, 112 (12), 1567
PubMed 1615504
[Immunophenotyping of leukemias]
Tidsskr Nor Laegeforen, 112 (18), 2373-4
PubMed 1412241
[Sugar molecules, cell adhesion and cancer etiology]
Tidsskr Nor Laegeforen, 112 (22), 2834
PubMed 1412318
Isolation and characterization of human hematopoietic progenitor cells: an effective method for positive selection of CD34+ cells
Leukemia, 6 (8), 845-52
PubMed 1379314
[Cytokines--from research to clinical use]
Tidsskr Nor Laegeforen, 112 (28), 3544
PubMed 1462323
Differential chromatin structure-dependent binding of 7-aminoactinomycin D in normal and malignant bone marrow hematopoietic cells
Cancer Res, 52 (18), 5007-12
PubMed 1516056
Publications 1991
Acute hepatotoxicity after high-dose methotrexate administration to rats
Pharmacol Toxicol, 69 (2), 132-9
DOI 10.1111/j.1600-0773.1991.tb01286.x, PubMed 1775433
The effect of vindesine on methotrexate hydroxylation in the rat
Biochem Pharmacol, 42 (8), 1561-8
DOI 10.1016/0006-2952(91)90425-5, PubMed 1930283
Inhibition of 7-hydroxymethotrexate formation by amsacrine
Cancer Chemother Pharmacol, 28 (5), 377-83
DOI 10.1007/BF00685693, PubMed 1914082
Use of size fractionation of in vitro-activated human B lymphocytes for studies of cell cycle-dependent growth regulation
Scand J Immunol, 33 (1), 51-60
DOI 10.1111/j.1365-3083.1991.tb02491.x, PubMed 1899949
Independent regulation of 55-kDa and 75-kDa tumor necrosis factor receptors during activation of human peripheral blood B lymphocytes
Eur J Immunol, 21 (4), 1033-7
DOI 10.1002/eji.1830210426, PubMed 1850359
Differential effects of interferon-gamma and low molecular weight BCGF on growth of human B lymphocytes; interferon-gamma prolongs the increased c-MYC mRNA levels after activation
Scand J Immunol, 33 (4), 365-73
DOI 10.1111/j.1365-3083.1991.tb01783.x, PubMed 1902001
Immunomagnetic isolation of NK and LAK cells
J Immunol Methods, 136 (1), 1-9
DOI 10.1016/0022-1759(91)90242-8, PubMed 1704900
Interleukin-7 differentiates a subgroup of acute lymphoblastic leukemias
Blood, 77 (11), 2445-50
PubMed 2039826
Retinyl esters in chylomicron remnants inhibit growth of myeloid and lymphoid leukaemic cells
Eur J Clin Invest, 21 (6), 574-9
DOI 10.1111/j.1365-2362.1991.tb01411.x, PubMed 1778218
Publications 1990
Functional properties of CD19+ B lymphocytes positively selected from buffy coats by immunomagnetic separation
Eur J Immunol, 20 (1), 201-6
DOI 10.1002/eji.1830200129, PubMed 1689662
Characterization of a new malignant human T-cell line (PFI-285) sensitive to ascorbic acid
Eur J Haematol, 44 (1), 9-17
DOI 10.1111/j.1600-0609.1990.tb00340.x, PubMed 2307225
A transient acidification linked to intracellular Ca2+ in anti-mu-stimulated human B-lymphocytes
Acta Physiol Scand, 138 (2), 221-7
DOI 10.1111/j.1748-1716.1990.tb08836.x, PubMed 1690498
Immunological typing of acute leukaemias by rosetting with immunomagnetic beads: comparison with immunofluorescence staining
Scand J Immunol, 31 (5), 567-73
DOI 10.1111/j.1365-3083.1990.tb02807.x, PubMed 2189214
Inhibition of polyphosphoinositide breakdown and c-myc induction accompanying inhibition of human B-cell activation by two monoclonal antibodies against the leucocyte common antigen (CD45)
Scand J Immunol, 31 (5), 583-91
DOI 10.1111/j.1365-3083.1990.tb02809.x, PubMed 1693226
The B cell antigen CD75 is a cell surface sialytransferase
J Exp Med, 172 (2), 641-3
DOI 10.1084/jem.172.2.641, PubMed 2373995
Publications 1989
[Experiences of immunologic phenotyping in acute leukemia]
Tidsskr Nor Laegeforen, 109 (4), 443-6
PubMed 2919374
[Gene technology in the prevention of cancer]
Tidsskr Nor Laegeforen, 109 (33), 3430-4
PubMed 2609305
Intracellular events associated with inhibition of B cell activation by monoclonal antibodies to HLA class II antigens
Eur J Immunol, 19 (7), 1221-5
DOI 10.1002/eji.1830190711, PubMed 2547623
Ki67 and 4F2 antigen expression as well as DNA synthesis predict survival at relapse/tumour progression in low-grade B-cell lymphoma
Int J Cancer, 44 (6), 975-80
DOI 10.1002/ijc.2910440605, PubMed 2606582
Levels of myc protein, as analyzed by flow cytometry, correlate with cell growth potential in malignant B-cell lymphomas
Int J Cancer, 43 (1), 164-70
DOI 10.1002/ijc.2910430130, PubMed 2642893
Interleukin 4 induces selective production of interleukin 6 from normal human B lymphocytes
J Exp Med, 170 (4), 1463-8
DOI 10.1084/jem.170.4.1463, PubMed 2677211
[The 1989 Nobel Prize in physiology and medicine]
Tidsskr Nor Laegeforen, 109 (34-36), 3541-2
PubMed 2694425
Publications 1988
Triggering of neoplastic B cells via surface IgM and the cell surface antigens CD20 and CDw40. Responses differ from normal blood B cells and are restricted to certain morphologic subsets
Int J Cancer, 42 (4), 521-8
DOI 10.1002/ijc.2910420409, PubMed 2459071
cAMP-mediated growth inhibition of a B-lymphoid precursor cell line Reh is associated with an early transient delay in G2/M, followed by an accumulation of cells in G1
J Cell Physiol, 137 (3), 583-7
DOI 10.1002/jcp.1041370327, PubMed 2848044
Cyclic AMP has the ability to influence multiple events during B cell stimulation
Eur J Immunol, 18 (9), 1359-66
DOI 10.1002/eji.1830180909, PubMed 2458941
[The immunoglobulin gene superfamily]
Tidsskr Nor Laegeforen, 108 (13), 1029-32, 1004
PubMed 2455362
[Cellular oncogenes. Role in normal cell growth and activation in neoplasms]
Tidsskr Nor Laegeforen, 108 (16), 1299-303
PubMed 3291192
Transcription of protooncogenes during stimulation of normal human B lymphocytes
Eur J Immunol, 18 (11), 1847-50
DOI 10.1002/eji.1830181131, PubMed 3060364
Retinol bound to physiological carrier molecules regulates growth and differentiation of myeloid leukemic cells
J Biol Chem, 263 (18), 8691-5
PubMed 3163997
Publications 1987
Epstein-Barr virus mediates a switch in responsiveness to transforming growth factor, type beta, in cells of the B cell lineage
Eur J Immunol, 17 (2), 299-301
DOI 10.1002/eji.1830170224, PubMed 3030769
Cyclic AMP-mediated suppression of normal and neoplastic B cell proliferation is associated with regulation of myc and Ha-ras protooncogenes
J Cell Physiol, 131 (3), 426-33
DOI 10.1002/jcp.1041310315, PubMed 3036888
The activation-associated antigen 4F2 predicts patient survival in low-grade B-cell lymphomas
Int J Cancer, 39 (5), 590-4
DOI 10.1002/ijc.2910390508, PubMed 3106247
Downregulation of c-myc RNA is not a prerequisite for reduced cell proliferation, but is associated with G1 arrest in B-lymphoid cell lines
Exp Cell Res, 172 (1), 84-91
DOI 10.1016/0014-4827(87)90095-4, PubMed 3115797
Regulation of human B cell growth in vitro
The Norwegian Radium Hospital/The Norwegian Cancer Society, Oslo, 1 b. (flere pag.)
BIBSYS 874163404, ISBN 82-90187-34-3
Regulation of c-myc transcription and protein expression during activation of normal human B cells
Exp Cell Res, 172 (1), 101-9
DOI 10.1016/0014-4827(87)90097-8, PubMed 3308492
Activation of human B cells: alternate options for initial triggering and effects of nonmitogenic concentrations of anti-IgM antibodies on resting and activated cells
J Immunol, 138 (10), 3179-84
PubMed 3553323
Transforming growth factor type beta (TGF beta) inhibits G1 to S transition, but not activation of human B lymphocytes
Exp Cell Res, 171 (1), 213-22
DOI 10.1016/0014-4827(87)90264-3, PubMed 2442015
Publications 1986
Effect of near normoglycaemia for two years on progression of early diabetic retinopathy, nephropathy, and neuropathy: the Oslo study
Br Med J (Clin Res Ed), 293 (6556), 1195-9
DOI 10.1136/bmj.293.6556.1195, PubMed 3096429
Characterization of human mononuclear cells after positive selection with immunomagnetic particles
Scand J Immunol, 23 (4), 509-19
DOI 10.1111/j.1365-3083.1986.tb03083.x, PubMed 2422741
IgG subclasses in lymphomas
Monogr Allergy, 19, 164-8
PubMed 3762542
Regulation of c-myc mRNA and protein levels during activation of normal human B cells
Curr Top Microbiol Immunol, 132, 290-6
DOI 10.1007/978-3-642-71562-4_43, PubMed 3539537
Publications 1985
Analyses of maximum cardiopulmonary performance during exposure to acute hypoxia at simulated altitude--sea level to 5000 meters (760-404 mm Hg)
Aviat Space Environ Med, 56 (12), 1192-7
PubMed 4084174
Antibodies to surface IgM and IgD increase the expression of various class II antigens on human B cells
Eur J Immunol, 15 (2), 173-7
DOI 10.1002/eji.1830150212, PubMed 3871699
Intracellular Ca2+ buffering potentiates an 86Rb+ permeability response in human lymphocytes
Acta Physiol Scand, 124 (2), 247-51
DOI 10.1111/j.1748-1716.1985.tb07658.x, PubMed 3925725
Characterization of two murine monoclonal antibodies reactive with human B cells. Their use in a high-yield, high-purity method for isolation of B cells and utilization of such cells in an assay for B-cell stimulating factor
Scand J Immunol, 21 (3), 205-14
DOI 10.1111/j.1365-3083.1985.tb01422.x, PubMed 3887557
The specific induction of myc protooncogene expression in normal human B cells is not a sufficient event for acquisition of competence to proliferate
Proc Natl Acad Sci U S A, 82 (18), 6255-9
DOI 10.1073/pnas.82.18.6255, PubMed 3929253
Publications 1984
Thyroid antibodies in blood donors: prevalence and clinical significance
Acta Endocrinol (Copenh), 105 (3), 324-9
DOI 10.1530/acta.0.1050324, PubMed 6702401
Surface IgG subclasses in human B cell lymphomas as revealed by monoclonal antibodies
Clin Exp Immunol, 57 (1), 163-70
PubMed 6378459
Modification of the 'dividing bradycardia' by hypoxia or exercise
Respir Physiol, 56 (2), 245-51
DOI 10.1016/0034-5687(84)90108-7, PubMed 6463431