
Erlend Bremertun Smeland
- Principal investigator MD/PhD
- +47 913 88 199
1980: MD, Univ. of Oslo
1980, ECFMG-exam, Copenhagen
Positions
1996 date, Scientific director, Council for Translational Researh
2003 date, Director, Institute for Cancer Research
1998 - date, Professor II in experimental hematology/stem cell transplantation, Medical Faculty, University of Oslo
Research interests/projects
- Studies of regulation of growth and differentiation of normal and neoplastic B-cells
- signal transduction; role of protein kinases
- effect and production of cytokines - Expression profiling of normal and neoplastic B cells
- Use of SEREX-technology and phage display technology to characterise tumor antigens
Previous employments
- Practical training (turnustjeneste), Narvik Hospital, July 1980-June 1981.
- General practice (district service) Førde, July 1981-January 1982
- Medical doctor, Hormone Laboratory, Aker Hospital, JanuarJune 1982.
- Military service, Institute of Aviation Medicine, University of Oslo, July 1982March 1983.
- Research fellow, The Norwegian Cancer Society, March 1983-October 1987
- Researcher at The Norwegian Cancer Society, October 1987, April 1988.
- Deputy Head, Laboratory for Immunology, The Norwegian Radium Hospital, May 1988-September 1992
- Head, Department of Immunology, The Norwegian Radium Hospital, December 1992-2002.
Assignments/duties
The Norwegian Radium Hospital:
- Board Member, Institute for Cancer Research, 1992- 2000.
- Deputy representative, the Board of The Norwegian Radium Hospital
- Co-ordinator, The Stem Cell Project 1990-1996, (Institutional high priority area of research and development).
- Member, Advisory Board for High Dose Therapy/Stem Cell Project (1992, to date)
- Member, Council for Research and Development, DNR from 1992
- Member of working group for the Committee for Research and Development,1993 date
- Head, Committee for Research and Development, May 1996 date.
- Member, Board for the Radium Hospital Research Foundation, 1997 to date.
- Member, Educational Committee, 1995- 97
- Member, Planning and Strategy Committee, 1995-1996
- Member, Building and Development Programme, 1997 to date.
- Member, Organisation Committee, 1998- January 1999
- Member, Working group for Vestenghaugen- project- 1997 1998
- Head, Committee for reorganisation of Institute for Cancer Research, 1999-2000.
- Director, Institute for Cancer Research
- Member, Coordinating Comittee NRH/Rikshospitalet, 2004
External tasks
- National co-ordinator for immunophenotyping of childhood leukemias in the Nordic countries, 1991-2000.
- Deputy member of the Board of the Norwegian Society for Immunology, 1992 to date
- Member of the co-ordinating panel for the new National Hospital, 1993
- Co-ordinator of Forum for Experimental Haematology, 1993-1998..
- Member of the Board of the Norwegian Cancer Society 1995 to date
- Member of the Steering committee for TV-aksjonen 1997 (The Norwegian Cancer Society)
- Head, Evaluation committee regarding gene therapy in Norway, appointed by Senter for Medisinsk Metodevurdering (SMM 1/2000): Future role of gene therapy in the Norwegian health care.
- Member the Norwegian Research Councils reference group regarding recruitment within medical research, 1998-1999.
- Member of Regional Scientific Committee, 18th International UICC Cancer Conference, Oslo 2000
- Member of the Postgenome Committee, Medical Faculty, University of Oslo, autumn 2000 2002.
- Board member FORNY-program, The Norwegian Research Council, 2002 2003.
- Head, Strategy Group for Research & Development, Helse Sør RHF, 2002.
- Member, Steering committee, National microarray consortium, 2001- date.
- Member, Coordinating Council (Samarbeidsorganet) between Helse Sør RHF, Helse Øst RHF and University of Oslo
- Member, National Research Strategy Group in Medical Research (coordinated by Health department)
Administrative experience
I have had administrative responsibility for Lab.for Immunology/Dept. of Immunology, The Norwegian Radium Hospital from 1986 to 2003. Section for Immunotherapy was included in the department in 1995 and there are now more than 30 persons employed at Department of Immunology. Approximately 2/3 of the budget for salaries, expenses and equipment are obtained from external sources. During this period I have together with Steinar Funderud had the scientific responsibility for the department. I have also been Head for the Council for Research and Development at the Norwegian Radium Hospital from 1996. The Council is an institutional council which co-ordinates research and development between the Institute for cancer research, the clinic and the industry. The Council for Research and Development is responsible for establishment and evaluation of priority areas of research and development at our institution that include high-dose therapy/stem cell therapy, detection of micrometastases, photodynamic therapy/photochemical internalisation, immunotherapy, gene therapy, clinical research unit/clinical pharmacology, radiation biology.
Research evaluation
- The Danish Cancer Society (40 million DK to cancer research, 1994)
- Evaluation committee regarding the DNR Research Foundation Cancer Research Price 1995-97.
- Member of FORNY board, The Norwegian Research Council, 2001-2003
- Member of evaluation committee of professor I position in experimental hematology , University of Copenhagen, 2003
- Opponent and member of evaluation committees for the following PhD students: dr.med. Marit Hellebostad, University o f Oslo, 1993; dr.med. Geir Erland Tjønnfjord, University of Oslo, 1995; dr.med. Magne Børset, Univerity of Trondheim 1996; dr.med. Inger Nina Farstad, University of Oslo, 1997; dr.philos. Marie Elisabeth Børrezen, University of Oslo, 1997; dr.philos. Vigdis Aas, University of Oslo, 1998; dr.scient.Trude Stensvik, University of Oslo, 1998; cand.med. Brynjar Landmark, University of Oslo, 1998; dr. philos. Ala-Al-Aoukaty, University of Oslo, 1999; dr. philos. Xiuli Wang, University of Oslo, 1999, PhD Thomas Rasmussen, University of Copenhagen, 1999, cand. med Rita Steen, University of Oslo, 1999); dr.philos Stine Ulven, University of Oslo 2000; dr.philos. Tanja Aarvak, University of Oslo 2000; dr.med.med. Ludvig Munthe, University of Oslo, 2001, dr.med. Torkel Wang, University of Oslo, 2003, Karoline Western Schjetne, UiO, 2003.
Author network for Erlend Bremertun Smeland by COREMINE medical
Publications 2019
TIGIT and PD-1 mark intratumoral T cells with reduced effector function in B-cell non-Hodgkin lymphoma
Cancer Immunol Res (in press)
DOI 10.1158/2326-6066.CIR-18-0351, PubMed 30659053
Publications 2018
The MCL35 gene expression proliferation assay predicts high-risk MCL patients in a Norwegian cohort of younger patients given intensive first line therapy
Br J Haematol, 183 (2), 225-234
DOI 10.1111/bjh.15518, PubMed 30080252
Molecular classification of primary mediastinal large B-cell lymphoma using routinely available tissue specimens
Blood, 132 (22), 2401-2405
DOI 10.1182/blood-2018-05-851154, PubMed 30257882
Artesunate shows potent anti-tumor activity in B-cell lymphoma
J Hematol Oncol, 11 (1), 23
DOI 10.1186/s13045-018-0561-0, PubMed 29458389
Publications 2017
BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-β receptor type I ALK5
PLoS One, 12 (5), e0177188
DOI 10.1371/journal.pone.0177188, PubMed 28489883
T Cells Expressing Checkpoint Receptor TIGIT Are Enriched in Follicular Lymphoma Tumors and Characterized by Reversible Suppression of T-cell Receptor Signaling
Clin Cancer Res, 24 (4), 870-881
DOI 10.1158/1078-0432.CCR-17-2337, PubMed 29217528
The management and survival outcomes of nasopharyngeal cancer in the Nordic countries
Acta Oncol, 57 (4), 557-560
DOI 10.1080/0284186X.2017.1408961, PubMed 29202641
New Molecular Assay for the Proliferation Signature in Mantle Cell Lymphoma Applicable to Formalin-Fixed Paraffin-Embedded Biopsies
J Clin Oncol, 35 (15), 1668-1677
DOI 10.1200/JCO.2016.70.7901, PubMed 28291392
Publications 2016
The tumour microenvironment influences survival and time to transformation in follicular lymphoma in the rituximab era
Br J Haematol, 175 (1), 102-14
DOI 10.1111/bjh.14201, PubMed 27341313
Publications 2015
Computerized image analysis of the Ki-67 proliferation index in mantle cell lymphoma
Histopathology, 67 (1), 62-9
DOI 10.1111/his.12624, PubMed 25431344
Primary diffuse large B-cell lymphoma associated with clonally-related monoclonal B lymphocytosis indicates a common precursor cell
Haematologica, 100 (10), e415-8
DOI 10.3324/haematol.2015.126656, PubMed 26001788
The targeting of human and mouse B lymphocytes by dasatinib
Exp Hematol, 43 (5), 352-363.e4
DOI 10.1016/j.exphem.2015.01.008, PubMed 25641047
Publications 2014
A gene panel, including LRP12, is frequently hypermethylated in major types of B-cell lymphoma
PLoS One, 9 (9), e104249
DOI 10.1371/journal.pone.0104249, PubMed 25226156
High dose chemotherapy with autologous stem cell transplant for patients with transformed B-cell non-Hodgkin lymphoma in the rituximab era
Leuk Lymphoma, 55 (10), 2319-27
DOI 10.3109/10428194.2013.871632, PubMed 24432894
Combining MYC, BCL2 and TP53 gene and protein expression alterations improves risk stratification in diffuse large B-cell lymphoma
Leuk Lymphoma, 56 (6), 1742-9
DOI 10.3109/10428194.2014.970550, PubMed 25284491
Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma
Nature, 516 (7530), 254-8
DOI 10.1038/nature13765, PubMed 25274307
Expression of B-cell surface antigens in subpopulations of exosomes released from B-cell lymphoma cells
Clin Ther, 36 (6), 847-862.e1
DOI 10.1016/j.clinthera.2014.05.010, PubMed 24952935
Prognostic influence of macrophages in patients with diffuse large B-cell lymphoma: a correlative study from a Nordic phase II trial
Haematologica, 100 (2), 238-45
DOI 10.3324/haematol.2014.113472, PubMed 25381134
Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue
Blood, 123 (8), 1214-7
DOI 10.1182/blood-2013-11-536433, PubMed 24398326
Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms
Cancer Discov, 4 (4), 480-93
DOI 10.1158/2159-8290.CD-13-0915, PubMed 24491438
Publications 2013
Identification of highly methylated genes across various types of B-cell non-hodgkin lymphoma
PLoS One, 8 (11), e79602
DOI 10.1371/journal.pone.0079602, PubMed 24260260
Colorectal cancer DNA methylation marker panel validated with high performance in Non-Hodgkin lymphoma
Epigenetics, 9 (3), 428-36
DOI 10.4161/epi.27554, PubMed 24362313
Whole-genome integrative analysis reveals expression signatures predicting transformation in follicular lymphoma
Blood, 123 (7), 1051-4
DOI 10.1182/blood-2013-07-512392, PubMed 24357726
EZH2 mutations are frequent and represent an early event in follicular lymphoma
Blood, 122 (18), 3165-8
DOI 10.1182/blood-2013-04-496893, PubMed 24052547
Karyotyping of diffuse large B-cell lymphomas: loss of 17p is associated with poor patient outcome
Eur J Haematol, 91 (4), 332-8
DOI 10.1111/ejh.12171, PubMed 23859481
Higher World Health Organization grades of follicular lymphoma correlate with better outcome in two Nordic Lymphoma Group trials of rituximab without chemotherapy
Leuk Lymphoma, 55 (2), 288-95
DOI 10.3109/10428194.2013.802778, PubMed 23662992
Influence of polymorphisms in genes encoding immunoregulatory proteins and metabolizing enzymes on susceptibility and outcome in patients with diffuse large B-cell lymphoma treated with rituximab
Leuk Lymphoma, 54 (10), 2205-14
DOI 10.3109/10428194.2013.774392, PubMed 23391141
Publications 2012
SARA is dispensable for functional TGF-β signaling
FEBS Lett, 586 (19), 3367-72
DOI 10.1016/j.febslet.2012.07.027, PubMed 22819827
Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma
PLoS One, 7 (10), e46117
DOI 10.1371/journal.pone.0046117, PubMed 23049692
Effect of cycloheximide on epidermal growth factor receptor trafficking and signaling
FEBS Lett, 586 (20), 3575-81
DOI 10.1016/j.febslet.2012.08.022, PubMed 22971756
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics
Nature, 490 (7418), 116-20
DOI 10.1038/nature11378, PubMed 22885699
Polymorphisms in genes encoding interleukin-10 and drug metabolizing enzymes GSTP1, GSTT1, GSTA1 and UGT1A1 influence risk and outcome in Hodgkin lymphoma
Leuk Lymphoma, 53 (10), 1934-44
DOI 10.3109/10428194.2012.682307, PubMed 22475179
Publications 2011
Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7
Eur J Immunol, 41 (11), 3135-45
DOI 10.1002/eji.201141558, PubMed 21898381
Side population cells in highly enriched CD34-positive cells from peripheral blood progenitor cells identify an immature subtype of hematopoietic progenitor cells but do not predict time to engraftment in patients treated with high-dose therapy
Eur J Haematol, 87 (6), 494-502
DOI 10.1111/j.1600-0609.2011.01681.x, PubMed 21752097
LMO2 expression reflects the different stages of blast maturation and genetic features in B-cell acute lymphoblastic leukemia and predicts clinical outcome
Haematologica, 96 (7), 980-6
DOI 10.3324/haematol.2011.040568, PubMed 21459790
Clinical significance of the WHO grades of follicular lymphoma in a population-based cohort of 505 patients with long follow-up times
Br J Haematol, 156 (2), 225-33
DOI 10.1111/j.1365-2141.2011.08942.x, PubMed 22126847
Publications 2010
TGF-β-induced growth inhibition in B-cell lymphoma correlates with Smad1/5 signalling and constitutively active p38 MAPK
BMC Immunol, 11, 57
DOI 10.1186/1471-2172-11-57, PubMed 21092277
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
Nature, 463 (7277), 88-92
DOI 10.1038/nature08638, PubMed 20054396
Genomic alterations reveal potential for higher grade transformation in follicular lymphoma and confirm parallel evolution of tumor cell clones
Blood, 116 (9), 1489-97
DOI 10.1182/blood-2010-03-272278, PubMed 20505157
Oncogenically active MYD88 mutations in human lymphoma
Nature, 470 (7332), 115-9
DOI 10.1038/nature09671, PubMed 21179087
Cooperative epigenetic modulation by cancer amplicon genes
Cancer Cell, 18 (6), 590-605
DOI 10.1016/j.ccr.2010.11.013, PubMed 21156283
[Close cooperation, but not oversteering]
Tidsskr Nor Laegeforen, 130 (6), 590-1
DOI 10.4045/tidsskr.10.0153, PubMed 20348990
[Leadership and academic competence]
Tidsskr Nor Laegeforen, 130 (6), 591
DOI 10.4045/tidsskr.10.0217, PubMed 20348994
Publications 2009
[Molecular diagnosis of malignant lymphomas]
Tidsskr Nor Laegeforen, 129 (22), 2352-6
DOI 10.4045/tidsskr.09.0704, PubMed 19935935
Array-based DNA methylation profiling in follicular lymphoma
Leukemia, 23 (10), 1858-66
DOI 10.1038/leu.2009.114, PubMed 19587707
Publications 2008
Oncogenic CARD11 mutations in human diffuse large B cell lymphoma
Science, 319 (5870), 1676-9
DOI 10.1126/science.1153629, PubMed 18323416
Stromal gene signatures in large-B-cell lymphomas
N Engl J Med, 359 (22), 2313-23
DOI 10.1056/NEJMoa0802885, PubMed 19038878
Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways
Proc Natl Acad Sci U S A, 105 (36), 13520-5
DOI 10.1073/pnas.0804295105, PubMed 18765795
The presence of TP53 mutation at diagnosis of follicular lymphoma identifies a high-risk group of patients with shortened time to disease progression and poorer overall survival
Blood, 112 (8), 3126-9
DOI 10.1182/blood-2008-05-154013, PubMed 18628487
Publications 2007
Characterization of early stages of human B cell development by gene expression profiling
J Immunol, 179 (6), 3662-71
DOI 10.4049/jimmunol.179.6.3662, PubMed 17785802
Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell lymphoma
J Exp Med, 204 (3), 633-43
DOI 10.1084/jem.20062041, PubMed 17353367
Inhibitory effects and target genes of bone morphogenetic protein 6 in Jurkat TAg cells
Eur J Immunol, 37 (10), 2937-48
DOI 10.1002/eji.200636759, PubMed 17899540
Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival
Blood, 109 (11), 4599-606
DOI 10.1182/blood-2006-08-039859, PubMed 17299095
Publications 2006
Molecular diagnosis of Burkitt's lymphoma
N Engl J Med, 354 (23), 2431-42
DOI 10.1056/NEJMoa055759, PubMed 16760443
BMP-6 inhibits human bone marrow B lymphopoiesis--upregulation of Id1 and Id3
Exp Hematol, 34 (1), 72-81
DOI 10.1016/j.exphem.2005.09.010, PubMed 16413393
Gain of chromosome 6p is an infrequent cause of increased PIM1 expression in B-cell non-Hodgkin's lymphomas
Leukemia, 20 (3), 539-42
DOI 10.1038/sj.leu.2404094, PubMed 16437153
PI3K/Akt-dependent Epo-induced signalling and target genes in human early erythroid progenitor cells
Br J Haematol, 135 (1), 117-28
DOI 10.1111/j.1365-2141.2006.06252.x, PubMed 16965383
Publications 2005
Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction
Blood, 106 (9), 3183-90
DOI 10.1182/blood-2005-04-1399, PubMed 16046532
BMP-6 inhibits growth of mature human B cells; induction of Smad phosphorylation and upregulation of Id1
BMC Immunol, 6, 9
DOI 10.1186/1471-2172-6-9, PubMed 15877825
PU.1 protein expression has a positive linear association with protein expression of germinal centre B cell genes including BCL-6, CD10, CD20 and CD22: identification of PU.1 putative binding sites in the BCL-6 promotor
J Pathol, 206 (3), 312-9
DOI 10.1002/path.1777, PubMed 15892171
Publications 2004
Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells
N Engl J Med, 351 (21), 2159-69
DOI 10.1056/NEJMoa041869, PubMed 15548776
Serological cloning of cancer/testis antigens expressed in prostate cancer using cDNA phage surface display
Cancer Immunol Immunother, 53 (5), 431-8
DOI 10.1007/s00262-003-0458-8, PubMed 14747957
NY-ESO-1 protein expression and humoral immune responses in prostate cancer
Prostate, 59 (4), 440-7
DOI 10.1002/pros.20025, PubMed 15065093
Analysis of the autoantibody repertoire in Burkitt's lymphoma patients: frequent response against the transcription factor ATF-2
Cancer Immunol Immunother, 53 (12), 1119-26
DOI 10.1007/s00262-004-0558-0, PubMed 15185015
Publications 2003
Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma
J Exp Med, 198 (6), 851-62
DOI 10.1084/jem.20031074, PubMed 12975453
The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma
Cancer Cell, 3 (2), 185-97
DOI 10.1016/S1535-6108(03)00028-X, PubMed 12620412
Publications 2002
Activation of phosphatidylinositol 3-kinase is important for erythropoietin-induced erythropoiesis from CD34(+) hematopoietic progenitor cells
Exp Hematol, 30 (9), 990-1000
PubMed 12225790
The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma
N Engl J Med, 346 (25), 1937-47
DOI 10.1056/NEJMoa012914, PubMed 12075054
Clustering of the SOM easily reveals distinct gene expression patterns: results of a reanalysis of lymphoma study
BMC Bioinformatics, 3, 36
DOI 10.1186/1471-2105-3-36, PubMed 12445336
Publications 2001
High-dose therapy in patients with Hodgkin's disease: the use of selected CD34(+) cells is as safe as unmanipulated peripheral blood progenitor cells
Bone Marrow Transplant, 28 (9), 849-57
DOI 10.1038/sj.bmt.1703244, PubMed 11781645
[Gene therapy in cancer]
Tidsskr Nor Laegeforen, 121 (4), 482-8
PubMed 11255868
[Gene therapy--status and recommendations in Norwegian health care system]
Tidsskr Nor Laegeforen, 121 (3), 343-8
PubMed 11242880
Loss of chromosome 11q21-23.1 and 17p and gain of chromosome 6p are independent prognostic indicators in B-cell non-Hodgkin's lymphoma
Br J Cancer, 85 (12), 1900-13
DOI 10.1054/bjoc.2001.2164, PubMed 11747333
Publications 2000
Identification of nucleolar protein No55 as a tumour-associated autoantigen in patients with prostate cancer
Br J Cancer, 83 (6), 743-9
DOI 10.1054/bjoc.2000.1365, PubMed 10952778
Differential expression of bcl-2 homologs in human CD34(+) hematopoietic progenitor cells induced to differentiate into erythroid or granulocytic cells
Stem Cells, 18 (4), 261-72
DOI 10.1634/stemcells.18-4-261, PubMed 10924092
Protein kinase C-alpha isoform is involved in erythropoietin-induced erythroid differentiation of CD34(+) progenitor cells from human bone marrow
Blood, 95 (2), 510-8
PubMed 10627456
cAMP-mediated growth inhibition of lymphoid cells in G1: rapid down-regulation of cyclin D3 at the level of translation
Eur J Immunol, 30 (6), 1757-68
DOI 10.1002/1521-4141(200006)30:6<1757::AID-IMMU1757>3.0.CO;2-N, PubMed 10898514
Oncogenic aberrations in the p53 pathway are associated with a high S phase fraction and poor patient survival in B-cell Non-Hodgkin's lymphoma
Int J Cancer, 89 (4), 313-24
DOI 10.1002/1097-0215(20000720)89:4<313::AID-IJC1>3.0.CO;2-D, PubMed 10956404
A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes
Blood, 95 (1), 221-30
PubMed 10607706
Publications 1999
Evaluation of lymphoid cell populations in cytology specimens using flow cytometry and polymerase chain reaction
Diagn Mol Pathol, 8 (4), 183-8
DOI 10.1097/00019606-199912000-00003, PubMed 10617274
Prognostic value of lymphoma-specific S-phase fraction compared with that of other cell proliferation markers
Acta Oncol, 38 (4), 495-503
DOI 10.1080/028418699432040, PubMed 10418718
Retinoic acid induces apoptosis of human CD34+ hematopoietic progenitor cells: involvement of retinoic acid receptors and retinoid X receptors depends on lineage commitment of the hematopoietic progenitor cells
Exp Hematol, 27 (4), 642-53
DOI 10.1016/S0301-472X(98)00073-3, PubMed 10210322
Fas ligand promotes cell survival of immature human bone marrow CD34+CD38- hematopoietic progenitor cells by suppressing apoptosis
Exp Hematol, 27 (9), 1451-9
DOI 10.1016/S0301-472X(99)00073-9, PubMed 10480436
Activation of the cAMP signaling pathway increases apoptosis in human B-precursor cells and is associated with downregulation of Mcl-1 expression
J Cell Physiol, 180 (1), 71-80
DOI 10.1002/(SICI)1097-4652(199907)180:1<71::AID-JCP8>3.0.CO;2-N, PubMed 10362019
Lovastatin inhibits G1/S transition of normal human B-lymphocytes independent of apoptosis
Exp Cell Res, 252 (1), 144-53
DOI 10.1006/excr.1999.4608, PubMed 10502407
[University function at the central hospital in Akershus]
Tidsskr Nor Laegeforen, 119 (11), 1647
PubMed 10385812
Publications 1998
Combination chemotherapy with mitoguazon, ifosfamide, MTX, etoposide (MIME) and G-CSF can efficiently mobilize PBPC in patients with Hodgkin's and non-Hodgkin's lymphoma
Bone Marrow Transplant, 21 (9), 873-8
DOI 10.1038/sj.bmt.1701192, PubMed 9613778
[Molecular genetic diagnosis of leukemias and lymphomas]
Tidsskr Nor Laegeforen, 118 (16), 2511-8
PubMed 9667131
[Chronic lymphatic leukemia. Immunophenotyping as an aid to correct diagnosis]
Tidsskr Nor Laegeforen, 118 (2), 233-7
PubMed 9485618
RAR-, not RXR, ligands inhibit cell activation and prevent apoptosis in B-lymphocytes
J Cell Physiol, 175 (1), 68-77
DOI 10.1002/(SICI)1097-4652(199804)175:1<68::AID-JCP8>3.0.CO;2-A, PubMed 9491782
Proliferation and apoptosis in malignant and normal cells in B-cell non-Hodgkin's lymphomas
Br J Cancer, 77 (11), 1832-8
DOI 10.1038/bjc.1998.304, PubMed 9667654
Tumour cell proliferation, but not apoptosis, predicts survival in B-cell non-Hodgkin's lymphomas
Br J Cancer, 77 (11), 1839-41
DOI 10.1038/bjc.1998.305, PubMed 9667655
Publications 1997
Involvement of ICE (Caspase) family in gamma-radiation-induced apoptosis of normal B lymphocytes
Scand J Immunol, 46 (6), 601-8
DOI 10.1046/j.1365-3083.1997.d01-173.x, PubMed 9420624
A novel putative G-protein-coupled receptor expressed in lung, heart and lymphoid tissue
FEBS Lett, 407 (1), 59-62
DOI 10.1016/S0014-5793(97)00278-0, PubMed 9141481
Interleukin-13 in combination with CD40 ligand potently inhibits apoptosis in human B lymphocytes: upregulation of Bcl-xL and Mcl-1
Blood, 89 (12), 4415-24
PubMed 9192766
CDw78--a determinant on a major histocompatibility complex class II subpopulation that can be induced to associate with the cytoskeleton
Eur J Immunol, 27 (12), 3206-13
DOI 10.1002/eji.1830271218, PubMed 9464807
[Changing physician's role]
Tidsskr Nor Laegeforen, 117 (29), 4290
PubMed 9441481
Characterization, expression and chromosomal localization of a human gene homologous to the mouse Lsc oncogene, with strongest expression in hematopoetic tissues
Oncogene, 14 (14), 1747-52
DOI 10.1038/sj.onc.1200994, PubMed 9135076
Publications 1996
[High-dose therapy of cancer with CD34 positive cells as stem cell support]
Tidsskr Nor Laegeforen, 116 (21), 2542-6
PubMed 8928121
Purging of tumor cells from leukapheresis products: experimental and clinical aspects
J Hematother, 5 (4), 427-36
DOI 10.1089/scd.1.1996.5.427, PubMed 8877718
Cyclic AMP-dependent protein kinase (cAK) in human B cells: co-localization of type I cAK (RI alpha 2 C2) with the antigen receptor during anti-immunoglobulin-induced B cell activation
Eur J Immunol, 26 (6), 1290-6
DOI 10.1002/eji.1830260617, PubMed 8647207
Expression of the Bcl-2 homologue Mcl-1 correlates with survival of peripheral blood B lymphocytes
Cancer Res, 56 (1), 40-3
PubMed 8548771
The RAR-RXR as well as the RXR-RXR pathway is involved in signaling growth inhibition of human CD34+ erythroid progenitor cells
Blood, 87 (5), 1728-36
PubMed 8634418
Solid-phase method for differential display of genes expressed in hematopoietic stem cells
Biotechniques, 21 (1), 114-21
DOI 10.2144/96211rr02, PubMed 8816245
High-dose 7-hydromethotrexate: acute toxicity and lethality in a rat model
Cancer Chemother Pharmacol, 37 (5), 415-22
DOI 10.1007/s002800050406, PubMed 8599863
Publications 1995
Semiquantitative polymerase chain reaction for t(14;18) in follicular lymphomas: a colorimetric approach
Lab Invest, 72 (4), 411-8
PubMed 7723279
All-trans- and 9-cis-retinoic acid inhibit growth of normal human and murine B cell precursors
J Immunol, 155 (1), 58-65
PubMed 7602122
TGF-beta 1 and cyclic AMP promote apoptosis in resting human B lymphocytes
J Immunol, 154 (4), 1634-43
PubMed 7836748
[Physicians liable for military service for sale]
Tidsskr Nor Laegeforen, 115 (24), 3072
PubMed 7570542
The effect of calcium channel blockers and calcium on methotrexate accumulation in rat hepatocytes
Anticancer Res, 15 (4), 1221-5
PubMed 7654001
Perturbation of methotrexate transport by verapamil, vinblastine, taurocholate and bromosulfophthalein in rat hepatocytes
Anticancer Res, 15 (1), 45-50
PubMed 7733639
Characterization of a promoter region supporting transcription of a novel human beta-galactoside alpha-2,6-sialyltransferase transcript in HepG2 cells
Biochim Biophys Acta, 1261 (1), 166-9
DOI 10.1016/0167-4781(94)00250-7, PubMed 7893756
Publications 1994
Retinoblastoma protein is rapidly dephosphorylated by elevated cyclic adenosine monophosphate levels in human B-lymphoid cells
Cancer Res, 54 (8), 2245-50
PubMed 8174134
Role of the 75-kDa tumor necrosis factor receptor: inhibition of early hematopoiesis
Proc Natl Acad Sci U S A, 91 (22), 10695-9
DOI 10.1073/pnas.91.22.10695, PubMed 7524102
All-trans- and 9-cis-retinoic acid: potent direct inhibitors of primitive murine hematopoietic progenitors in vitro
J Exp Med, 179 (5), 1665-70
PubMed 8163945
Autologous bone marrow transplantation of non-Hodgkin's lymphoma patients with marrow purged using immunomagnetic beads
Prog Clin Biol Res, 389, 133-8
PubMed 7700895
[Bone marrow transplantation--a constantly developing procedure--requiring updating]
Tidsskr Nor Laegeforen, 114 (3), 302-3
PubMed 8191422
Cross-linking of CD53 promotes activation of resting human B lymphocytes
J Immunol, 153 (11), 4997-5007
PubMed 7963560
Bifunctional effects of tumor necrosis factor alpha (TNF alpha) on the growth of mature and primitive human hematopoietic progenitor cells: involvement of p55 and p75 TNF receptors
Blood, 83 (11), 3152-9
PubMed 7514902
Functional differences between CD38- and DR- subfractions of CD34+ bone marrow cells
Blood, 84 (5), 1473-81
PubMed 7520773
Tumor necrosis factor-alpha inhibits stem cell factor-induced proliferation of human bone marrow progenitor cells in vitro. Role of p55 and p75 tumor necrosis factor receptors
J Clin Invest, 94 (1), 165-72
DOI 10.1172/JCI117303, PubMed 7518828
Renal and hepatic toxicity after high-dose 7-hydroxymethotrexate in the rat
Cancer Chemother Pharmacol, 34 (2), 119-24
PubMed 8194163
All-trans retinoic acid directly inhibits granulocyte colony-stimulating factor-induced proliferation of CD34+ human hematopoietic progenitor cells
Blood, 84 (9), 2940-5
PubMed 7524761
A simple subtraction method for the isolation of cell-specific genes using magnetic monodisperse polymer particles
Biotechniques, 16 (4), 716-21
PubMed 8024795
Tissue specific expression and cDNA structure of a human transcript encoding a nucleic acid binding [oligo(dC)] protein related to the pre-mRNA binding protein K
Nucleic Acids Res, 22 (6), 959-64
DOI 10.1093/nar/22.6.959, PubMed 8152927
Publications 1993
Constitutive expression of c-myc does not relieve cAMP-mediated growth arrest in human lymphoid Reh cells
J Cell Physiol, 157 (1), 61-9
DOI 10.1002/jcp.1041570108, PubMed 8408242
Expression of CD18 (integrin beta 2 chain) correlates with prognosis in malignant B cell lymphomas
Br J Haematol, 83 (3), 392-8
DOI 10.1111/j.1365-2141.1993.tb04662.x, PubMed 8097923
Cytotoxic lymphocyte maturation factor (interleukin 12) is a synergistic growth factor for hematopoietic stem cells
J Exp Med, 178 (2), 413-8
DOI 10.1084/jem.178.2.413, PubMed 7688022
Leukemic blasts with markers of four cell lineages in Down's syndrome ("megakaryoblastic leukemia")
Med Pediatr Oncol, 21 (4), 254-8
DOI 10.1002/mpo.2950210404, PubMed 8469219
Interactions of vinblastine and vincristine with methotrexate transport in isolated rat hepatocytes
Cancer Chemother Pharmacol, 32 (3), 209-14
DOI 10.1007/BF00685837, PubMed 8500226
Cell-specific expression of human beta-galactoside alpha 2,6-sialyltransferase transcripts differing in the 5' untranslated region
Eur J Biochem, 213 (1), 467-75
DOI 10.1111/j.1432-1033.1993.tb17783.x, PubMed 8477718
Publications 1992
Vitamin A is a key regulator for cell growth, cytokine production, and differentiation in normal B cells
J Biol Chem, 267 (33), 23988-92
PubMed 1429735
Cell cycle-dependent regulation of CDw75 (beta-galactoside alpha-2,6-sialyltransferase) on human B lymphocytes
Eur J Immunol, 22 (5), 1149-55
DOI 10.1002/eji.1830220507, PubMed 1577059
A new method for detachment of Dynabeads from positively selected B lymphocytes
J Immunol Methods, 146 (2), 195-202
DOI 10.1016/0022-1759(92)90228-L, PubMed 1371532
[Programmed cell death--significance for cancer etiology and treatment]
Tidsskr Nor Laegeforen, 112 (12), 1567
PubMed 1615504
[Immunophenotyping of leukemias]
Tidsskr Nor Laegeforen, 112 (18), 2373-4
PubMed 1412241
[Sugar molecules, cell adhesion and cancer etiology]
Tidsskr Nor Laegeforen, 112 (22), 2834
PubMed 1412318
Isolation and characterization of human hematopoietic progenitor cells: an effective method for positive selection of CD34+ cells
Leukemia, 6 (8), 845-52
PubMed 1379314
[Cytokines--from research to clinical use]
Tidsskr Nor Laegeforen, 112 (28), 3544
PubMed 1462323
Differential chromatin structure-dependent binding of 7-aminoactinomycin D in normal and malignant bone marrow hematopoietic cells
Cancer Res, 52 (18), 5007-12
PubMed 1516056
Publications 1991
Acute hepatotoxicity after high-dose methotrexate administration to rats
Pharmacol Toxicol, 69 (2), 132-9
DOI 10.1111/j.1600-0773.1991.tb01286.x, PubMed 1775433
The effect of vindesine on methotrexate hydroxylation in the rat
Biochem Pharmacol, 42 (8), 1561-8
DOI 10.1016/0006-2952(91)90425-5, PubMed 1930283
Inhibition of 7-hydroxymethotrexate formation by amsacrine
Cancer Chemother Pharmacol, 28 (5), 377-83
DOI 10.1007/BF00685693, PubMed 1914082
Use of size fractionation of in vitro-activated human B lymphocytes for studies of cell cycle-dependent growth regulation
Scand J Immunol, 33 (1), 51-60
DOI 10.1111/j.1365-3083.1991.tb02491.x, PubMed 1899949
Independent regulation of 55-kDa and 75-kDa tumor necrosis factor receptors during activation of human peripheral blood B lymphocytes
Eur J Immunol, 21 (4), 1033-7
DOI 10.1002/eji.1830210426, PubMed 1850359
Differential effects of interferon-gamma and low molecular weight BCGF on growth of human B lymphocytes; interferon-gamma prolongs the increased c-MYC mRNA levels after activation
Scand J Immunol, 33 (4), 365-73
DOI 10.1111/j.1365-3083.1991.tb01783.x, PubMed 1902001
Immunomagnetic isolation of NK and LAK cells
J Immunol Methods, 136 (1), 1-9
DOI 10.1016/0022-1759(91)90242-8, PubMed 1704900
Interleukin-7 differentiates a subgroup of acute lymphoblastic leukemias
Blood, 77 (11), 2445-50
PubMed 2039826
Retinyl esters in chylomicron remnants inhibit growth of myeloid and lymphoid leukaemic cells
Eur J Clin Invest, 21 (6), 574-9
DOI 10.1111/j.1365-2362.1991.tb01411.x, PubMed 1778218
Publications 1990
Functional properties of CD19+ B lymphocytes positively selected from buffy coats by immunomagnetic separation
Eur J Immunol, 20 (1), 201-6
DOI 10.1002/eji.1830200129, PubMed 1689662
Characterization of a new malignant human T-cell line (PFI-285) sensitive to ascorbic acid
Eur J Haematol, 44 (1), 9-17
PubMed 2307225
A transient acidification linked to intracellular Ca2+ in anti-mu-stimulated human B-lymphocytes
Acta Physiol Scand, 138 (2), 221-7
DOI 10.1111/j.1748-1716.1990.tb08836.x, PubMed 1690498
Immunological typing of acute leukaemias by rosetting with immunomagnetic beads: comparison with immunofluorescence staining
Scand J Immunol, 31 (5), 567-73
DOI 10.1111/j.1365-3083.1990.tb02807.x, PubMed 2189214
Inhibition of polyphosphoinositide breakdown and c-myc induction accompanying inhibition of human B-cell activation by two monoclonal antibodies against the leucocyte common antigen (CD45)
Scand J Immunol, 31 (5), 583-91
DOI 10.1111/j.1365-3083.1990.tb02809.x, PubMed 1693226
The B cell antigen CD75 is a cell surface sialytransferase
J Exp Med, 172 (2), 641-3
DOI 10.1084/jem.172.2.641, PubMed 2373995
Publications 1989
[Experiences of immunologic phenotyping in acute leukemia]
Tidsskr Nor Laegeforen, 109 (4), 443-6
PubMed 2919374
[Gene technology in the prevention of cancer]
Tidsskr Nor Laegeforen, 109 (33), 3430-4
PubMed 2609305
Intracellular events associated with inhibition of B cell activation by monoclonal antibodies to HLA class II antigens
Eur J Immunol, 19 (7), 1221-5
DOI 10.1002/eji.1830190711, PubMed 2547623
Ki67 and 4F2 antigen expression as well as DNA synthesis predict survival at relapse/tumour progression in low-grade B-cell lymphoma
Int J Cancer, 44 (6), 975-80
DOI 10.1002/ijc.2910440605, PubMed 2606582
Levels of myc protein, as analyzed by flow cytometry, correlate with cell growth potential in malignant B-cell lymphomas
Int J Cancer, 43 (1), 164-70
DOI 10.1002/ijc.2910430130, PubMed 2642893
Interleukin 4 induces selective production of interleukin 6 from normal human B lymphocytes
J Exp Med, 170 (4), 1463-8
DOI 10.1084/jem.170.4.1463, PubMed 2677211
[The 1989 Nobel Prize in physiology and medicine]
Tidsskr Nor Laegeforen, 109 (34-36), 3541-2
PubMed 2694425
Publications 1988
Triggering of neoplastic B cells via surface IgM and the cell surface antigens CD20 and CDw40. Responses differ from normal blood B cells and are restricted to certain morphologic subsets
Int J Cancer, 42 (4), 521-8
DOI 10.1002/ijc.2910420409, PubMed 2459071
cAMP-mediated growth inhibition of a B-lymphoid precursor cell line Reh is associated with an early transient delay in G2/M, followed by an accumulation of cells in G1
J Cell Physiol, 137 (3), 583-7
DOI 10.1002/jcp.1041370327, PubMed 2848044
Cyclic AMP has the ability to influence multiple events during B cell stimulation
Eur J Immunol, 18 (9), 1359-66
DOI 10.1002/eji.1830180909, PubMed 2458941
[The immunoglobulin gene superfamily]
Tidsskr Nor Laegeforen, 108 (13), 1029-32, 1004
PubMed 2455362
[Cellular oncogenes. Role in normal cell growth and activation in neoplasms]
Tidsskr Nor Laegeforen, 108 (16), 1299-303
PubMed 3291192
Transcription of protooncogenes during stimulation of normal human B lymphocytes
Eur J Immunol, 18 (11), 1847-50
DOI 10.1002/eji.1830181131, PubMed 3060364
Retinol bound to physiological carrier molecules regulates growth and differentiation of myeloid leukemic cells
J Biol Chem, 263 (18), 8691-5
PubMed 3163997
Publications 1987
Epstein-Barr virus mediates a switch in responsiveness to transforming growth factor, type beta, in cells of the B cell lineage
Eur J Immunol, 17 (2), 299-301
DOI 10.1002/eji.1830170224, PubMed 3030769
Cyclic AMP-mediated suppression of normal and neoplastic B cell proliferation is associated with regulation of myc and Ha-ras protooncogenes
J Cell Physiol, 131 (3), 426-33
DOI 10.1002/jcp.1041310315, PubMed 3036888
The activation-associated antigen 4F2 predicts patient survival in low-grade B-cell lymphomas
Int J Cancer, 39 (5), 590-4
DOI 10.1002/ijc.2910390508, PubMed 3106247
Downregulation of c-myc RNA is not a prerequisite for reduced cell proliferation, but is associated with G1 arrest in B-lymphoid cell lines
Exp Cell Res, 172 (1), 84-91
DOI 10.1016/0014-4827(87)90095-4, PubMed 3115797
Regulation of c-myc transcription and protein expression during activation of normal human B cells
Exp Cell Res, 172 (1), 101-9
DOI 10.1016/0014-4827(87)90097-8, PubMed 3308492
Activation of human B cells: alternate options for initial triggering and effects of nonmitogenic concentrations of anti-IgM antibodies on resting and activated cells
J Immunol, 138 (10), 3179-84
PubMed 3553323
Transforming growth factor type beta (TGF beta) inhibits G1 to S transition, but not activation of human B lymphocytes
Exp Cell Res, 171 (1), 213-22
DOI 10.1016/0014-4827(87)90264-3, PubMed 2442015
Publications 1986
Effect of near normoglycaemia for two years on progression of early diabetic retinopathy, nephropathy, and neuropathy: the Oslo study
Br Med J (Clin Res Ed), 293 (6556), 1195-9
DOI 10.1136/bmj.293.6556.1195, PubMed 3096429
Characterization of human mononuclear cells after positive selection with immunomagnetic particles
Scand J Immunol, 23 (4), 509-19
PubMed 2422741
IgG subclasses in lymphomas
Monogr Allergy, 19, 164-8
PubMed 3762542
Regulation of c-myc mRNA and protein levels during activation of normal human B cells
Curr Top Microbiol Immunol, 132, 290-6
PubMed 3539537
Publications 1985
Analyses of maximum cardiopulmonary performance during exposure to acute hypoxia at simulated altitude--sea level to 5000 meters (760-404 mm Hg)
Aviat Space Environ Med, 56 (12), 1192-7
PubMed 4084174
Antibodies to surface IgM and IgD increase the expression of various class II antigens on human B cells
Eur J Immunol, 15 (2), 173-7
DOI 10.1002/eji.1830150212, PubMed 3871699
Intracellular Ca2+ buffering potentiates an 86Rb+ permeability response in human lymphocytes
Acta Physiol Scand, 124 (2), 247-51
DOI 10.1111/j.1748-1716.1985.tb07658.x, PubMed 3925725
Characterization of two murine monoclonal antibodies reactive with human B cells. Their use in a high-yield, high-purity method for isolation of B cells and utilization of such cells in an assay for B-cell stimulating factor
Scand J Immunol, 21 (3), 205-14
DOI 10.1111/j.1365-3083.1985.tb01422.x, PubMed 3887557
The specific induction of myc protooncogene expression in normal human B cells is not a sufficient event for acquisition of competence to proliferate
Proc Natl Acad Sci U S A, 82 (18), 6255-9
DOI 10.1073/pnas.82.18.6255, PubMed 3929253
Publications 1984
Thyroid antibodies in blood donors: prevalence and clinical significance
Acta Endocrinol (Copenh), 105 (3), 324-9
PubMed 6702401
Surface IgG subclasses in human B cell lymphomas as revealed by monoclonal antibodies
Clin Exp Immunol, 57 (1), 163-70
PubMed 6378459
Modification of the 'dividing bradycardia' by hypoxia or exercise
Respir Physiol, 56 (2), 245-51
DOI 10.1016/0034-5687(84)90108-7, PubMed 6463431