Publications 2024

Kvistad CE, Lehmann AK, Kvistad SAS, Holmøy T, Lorentzen ÅR, Trovik LH, Kristoffersen EK, Bø L, Torkildsen Ø (2024)
Autologous hematopoietic stem cell transplantation for multiple sclerosis: Long-term follow-up data from Norway
Mult Scler, 13524585241231665 (in press)
DOI 10.1177/13524585241231665, PubMed 38345003

Skarstein I, Ulvestad E, Solheim AM, Vedeler C, Ljøstad U, Mygland Å, Eikeland R, Reiso H, Lorentzen ÅR, Bos SD (2024)
Serum neurofilament light chain associates with symptom burden in Lyme neuroborreliosis patients: a longitudinal cohort study from Norway
J Neurol (in press)
DOI 10.1007/s00415-024-12237-z, PubMed 38407594

Publications 2023

Lindland ES, Solheim AM, Andreassen S, Bugge R, Eikeland R, Reiso H, Lorentzen ÅR, Harbo HF, Beyer MK, Bjørnerud A (2023)
Dynamic contrast-enhanced MRI shows altered blood-brain barrier function of deep gray matter structures in neuroborreliosis: a case-control study
Eur Radiol Exp, 7 (1), 52
DOI 10.1186/s41747-023-00365-6, PubMed 37710058

Lorentzen ÅR, Berg KK, Ljøstad U (2023)
Rituximab leading to an atypical presentation of neuroborreliosis and false negative serology
Pract Neurol (in press)
DOI 10.1136/pn-2023-003976, PubMed 38135497

Publications 2022

Andreassen S, Lindland EMS, Beyer MK, Solheim AM, Ljøstad U, Mygland Å, Lorentzen ÅR, Reiso H, Bjuland KJ, Pripp AH, Harbo HF, Løhaugen GCC, Eikeland R (2022)
Assessment of cognitive function, structural brain changes and fatigue 6 months after treatment of neuroborreliosis
J Neurol, 270 (3), 1430-1438
DOI 10.1007/s00415-022-11463-7, PubMed 36380166

Andreassen S, Solheim AM, Ljøstad U, Mygland Å, Lorentzen ÅR, Reiso H, Beyer MK, Harbo HF, Løhaugen GCC, Eikeland R (2022)
Cognitive function in patients with neuroborreliosis: A prospective cohort study from the acute phase to 12 months post treatment
Brain Behav, 12 (6), e2608
DOI 10.1002/brb3.2608, PubMed 35593485

Bernardshaw E, Gynthersen RMM, Bremell D, Mens H, Stenør C, Lorentzen ÅR, Bodilsen J, Eikeland R, Lebech AM (2022)
Antibiotic therapy of neuroborreliosis: A survey among infectious disease specialists and neurologists in Norway, Sweden, and Denmark
Ticks Tick Borne Dis, 13 (6), 102051
DOI 10.1016/j.ttbdis.2022.102051, PubMed 36228536

Lindland ES, Solheim AM, Dareez MN, Eikeland R, Ljøstad U, Mygland Å, Reiso H, Lorentzen ÅR, Harbo HF, Beyer MK (2022)
Enhancement of cranial nerves in Lyme neuroborreliosis: incidence and correlation with clinical symptoms and prognosis
Neuroradiology, 64 (12), 2323-2333
DOI 10.1007/s00234-022-02957-2, PubMed 35608630

Solheim AM, Lorentzen ÅR, Dahlberg AO, Flemmen HØ, Brune S, Forselv KJN, Pripp AH, Bø MH, Eikeland R, Reiso H, Mygland Å, Ljøstad U (2022)
Six versus 2 weeks treatment with doxycycline in European Lyme neuroborreliosis: a multicentre, non-inferiority, double-blinded, randomised and placebo-controlled trial
J Neurol Neurosurg Psychiatry, 93 (11), 1222-8 (in press)
DOI 10.1136/jnnp-2022-329724, PubMed 35896378

Publications 2021

Andreassen S, Lindland EMS, Solheim AM, Beyer MK, Ljøstad U, Mygland Å, Lorentzen ÅR, Reiso H, Harbo HF, Løhaugen GCC, Eikeland R (2021)
Cognitive function, fatigue and Fazekas score in patients with acute neuroborreliosis
Ticks Tick Borne Dis, 12 (3), 101678
DOI 10.1016/j.ttbdis.2021.101678, PubMed 33529985

Eid K, Torkildsen ØF, Aarseth J, Flemmen HØ, Holmøy T, Lorentzen ÅR, Myhr KM, Riise T, Simonsen C, Torkildsen CF, Wergeland S, Willumsen JS, Øksendal N, Gilhus NE, Bjørk MH (2021)
Perinatal Depression and Anxiety in Women With Multiple Sclerosis: A Population-Based Cohort Study
Neurology, 96 (23), e2789-e2800
DOI 10.1212/WNL.0000000000012062, PubMed 33883236

Hoiberg HK, Solheim AM, Noraas S, Lorentzen AR (2021)
Acrodermatitis chronica atrophicans in prolonged borrelia infection
Tidsskr. Nor. Laegeforen., 141 (16), 1541-1542

Høiberg HK, Solheim AM, Noraas S, Lorentzen ÅR (2021)
Acrodermatitis chronica atrophicans in prolonged borrelia infection
Tidsskr Nor Laegeforen, 141 (16)
DOI 10.4045/tidsskr.21.0201, PubMed 34758594

König M, Lorentzen ÅR, Torgauten HM, Tran TT, Schikora-Rustad S, Vaage EB, Mygland Å, Wergeland S, Aarseth J, Aaberge IAS, Torkildsen Ø, Holmøy T, Berge T, Myhr KM, Harbo HF, Andersen JT, Munthe LA, Søraas A, Celius EG, Vaage JT, Lund-Johansen F, Nygaard GO (2021)
Humoral immunity to SARS-CoV-2 mRNA vaccination in multiple sclerosis: the relevance of time since last rituximab infusion and first experience from sporadic revaccinations
J Neurol Neurosurg Psychiatry, 94 (1), 19-22
DOI 10.1136/jnnp-2021-327612, PubMed 34670844

Quarsten H, Salte T, Lorentzen ÅR, Hansen IJW, Hamre R, Forselv KJN, Øines Ø, Wennerås C, Noraas S (2021)
Tick-borne Pathogens Detected in the Blood of Immunosuppressed Norwegian Patients Living in a Tick-endemic Area
Clin Infect Dis, 73 (7), e2364-e2371
DOI 10.1093/cid/ciaa971, PubMed 32662513

Publications 2020

Eikeland R, Ljøstad U, Helgeland G, Sand G, Flemmen HØ, Bø MH, Nordaa L, Owe JF, Mygland Å, Lorentzen ÅR (2020)
Patient-reported outcome after treatment for definite Lyme neuroborreliosis
Brain Behav, 10 (4), e01595
DOI 10.1002/brb3.1595, PubMed 32153118

Thortveit ET, Aase A, Petersen LB, Lorentzen ÅR, Mygland Å, Ljøstad U (2020)
Human seroprevalence of antibodies to tick-borne microbes in southern Norway
Ticks Tick Borne Dis, 11 (4), 101410
DOI 10.1016/j.ttbdis.2020.101410, PubMed 32156478

Thortveit ET, Aase A, Petersen LB, Lorentzen ÅR, Mygland Å, Ljøstad U (2020)
Subjective health complaints and exposure to tick-borne infections in southern Norway
Acta Neurol Scand, 142 (3), 260-266
DOI 10.1111/ane.13263, PubMed 32392618

Publications 2019

Lager M, Dessau RB, Wilhelmsson P, Nyman D, Jensen GF, Matussek A, Lindgren PE, Henningsson AJ, ScandTick Biobank Study Group, Baqir H, Serrander L, Johansson M, Tjernberg I, Skarstein I, Ulvestad E, Grude N, Pedersen AB, Bredberg A, Veflingstad R, Wass L, Aleke J, Nordberg M, Nyberg C, Perander L, Bojesson C et al. (2019)
Serological diagnostics of Lyme borreliosis: comparison of assays in twelve clinical laboratories in Northern Europe
Eur J Clin Microbiol Infect Dis, 38 (10), 1933-1945
DOI 10.1007/s10096-019-03631-x, PubMed 31399914

Publications 2018

Lindland ES, Solheim AM, Andreassen S, Quist-Paulsen E, Eikeland R, Ljøstad U, Mygland Å, Elsais A, Nygaard GO, Lorentzen ÅR, Harbo HF, Beyer MK (2018)
Imaging in Lyme neuroborreliosis
Insights Imaging, 9 (5), 833-844
DOI 10.1007/s13244-018-0646-x, PubMed 30187265

Thortveit ET, Lorentzen ÅR, Ljøstad U, Mygland Å (2018)
Somatic symptoms and fatigue in a Norwegian population with high exposure to ticks
Ticks Tick Borne Dis, 10 (1), 156-161
DOI 10.1016/j.ttbdis.2018.09.012, PubMed 30337264

Publications 2017

Forselv KJN, Lorentzen ÅR, Ljøstad U, Mygland Å, Eikeland R, Kjelland V, Noraas S, Quarsten H (2017)
Does more favourable handling of the cerebrospinal fluid increase the diagnostic sensitivity of Borrelia burgdorferi sensu lato-specific PCR in Lyme neuroborreliosis?
Infect Dis (Lond), 50 (4), 297-302
DOI 10.1080/23744235.2017.1399315, PubMed 29125008

Lorentzen ÅR, Forselv KJN, Helgeland G, Salvesen RE, Sand G, Flemmen HØ, Bø MH, Nordaa L, Roos AK, Jim MW, Owe JF, Nyquist KB, Schüler S, Eikeland R, Mygland Å, Ljøstad U (2017)
Lyme neuroborreliosis: do we treat according to guidelines?
J Neurol, 264 (7), 1506-1510
DOI 10.1007/s00415-017-8559-z, PubMed 28676925

Lossius A, Tomescu-Baciu A, Holmøy T, Vedeler CA, Røsjø E, Lorentzen ÅR, Casetta I, Vartdal F (2017)
Selective intrathecal enrichment of G1m1-positive B cells in multiple sclerosis
Ann Clin Transl Neurol, 4 (10), 756-761
DOI 10.1002/acn3.451, PubMed 29046884

Publications 2013

Borsig L, Wolf MJ, Roblek M, Lorentzen A, Heikenwalder M (2013)
Inflammatory chemokines and metastasis--tracing the accessory
Oncogene, 33 (25), 3217-24
DOI 10.1038/onc.2013.272, PubMed 23851506

Publications 2012

Link J, Kockum I, Lorentzen AR, Lie BA, Celius EG, Westerlind H, Schaffer M, Alfredsson L, Olsson T, Brynedal B, Harbo HF, Hillert J (2012)
Importance of human leukocyte antigen (HLA) class I and II alleles on the risk of multiple sclerosis
PLoS One, 7 (5), e36779
DOI 10.1371/journal.pone.0036779, PubMed 22586495

Maniaol AH, Elsais A, Lorentzen ÅR, Owe JF, Viken MK, Sæther H, Flåm ST, Bråthen G, Kampman MT, Midgard R, Christensen M, Rognerud A, Kerty E, Gilhus NE, Tallaksen CM, Lie BA, Harbo HF (2012)
Late onset myasthenia gravis is associated with HLA DRB1*15:01 in the Norwegian population
PLoS One, 7 (5), e36603
DOI 10.1371/journal.pone.0036603, PubMed 22590574

Mero IL, Smestad C, Lie BA, Lorentzen ÅR, Sandvik L, Landrø NI, Aarseth JH, Myhr KM, Celius EG, Harbo HF (2012)
Polymorphisms of the BDNF gene show neither association with multiple sclerosis susceptibility nor clinical course
J Neuroimmunol, 244 (1-2), 107-10
DOI 10.1016/j.jneuroim.2012.01.011, PubMed 22341604

Publications 2011

Harbo HF, Lorentzen AR, Lie BA, Celius EG, Spurkland A (2011)
[New gene map for multiple sclerosis]
Tidsskr Nor Laegeforen, 131 (21), 2126-30
DOI 10.4045/tidsskr.10.0823, PubMed 22048209

International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium 2, Sawcer S, Hellenthal G, Pirinen M, Spencer CC, Patsopoulos NA, Moutsianas L, Dilthey A, Su Z, Freeman C, Hunt SE, Edkins S, Gray E, Booth DR, Potter SC, Goris A, Band G, Oturai AB, Strange A, Saarela J, Bellenguez C, Fontaine B, Gillman M, Hemmer B et al. (2011)
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
Nature, 476 (7359), 214-9
DOI 10.1038/nature10251, PubMed 21833088

Lundström W, Greiner E, Lundmark F, Westerlind H, Smestad C, Lorentzen AR, Kockum I, Link J, Brynedal B, Celius EG, Harbo HF, Masterman T, Hillert J (2011)
No influence on disease progression of non-HLA susceptibility genes in MS
J Neuroimmunol, 237 (1-2), 98-100
DOI 10.1016/j.jneuroim.2011.05.003, PubMed 21742385

Publications 2010

International Multiple Sclerosis Genetics Consortium (IMSGC), Booth DR, Heard RN, Stewart GJ, Cox M, Scott RJ, Lechner-Scott J, Goris A, Dobosi R, Dubois B, Saarela J, Leppä V, Peltonen L, Pirttila T, Cournu-Rebeix I, Fontaine B, Bergamaschi L, D'Alfonso S, Leone M, Lorentzen AR, Harbo HF, Celius EG, Spurkland A, Link J, Kockum I et al. (2010)
Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis
Nat Genet, 42 (6), 469-70; author reply 470-1
DOI 10.1038/ng0610-469, PubMed 20502484

Link J, Lorentzen AR, Kockum I, Duvefelt K, Lie BA, Celius EG, Harbo HF, Hillert J, Brynedal B (2010)
Two HLA class I genes independently associated with multiple sclerosis
J Neuroimmunol, 226 (1-2), 172-6
DOI 10.1016/j.jneuroim.2010.07.006, PubMed 20678810

Lorentzen AR, Melum E, Ellinghaus E, Smestad C, Mero IL, Aarseth JH, Myhr KM, Celius EG, Lie BA, Karlsen TH, Franke A, Harbo HF (2010)
Association to the Glypican-5 gene in multiple sclerosis
J Neuroimmunol, 226 (1-2), 194-7
DOI 10.1016/j.jneuroim.2010.07.003, PubMed 20692050

Mero IL, Ban M, Lorentzen ÅR, Smestad C, Celius EG, Sæther H, Saeedi H, Viken MK, Skinningsrud B, Undlien DE, Aarseth J, Myhr KM, Granum S, Spurkland A, Sawcer S, Compston A, Lie BA, Harbo HF (2010)
Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus
Genes Immun, 12 (3), 191-8
DOI 10.1038/gene.2010.59, PubMed 21179112

Publications 2009

Ban M, Goris A, Lorentzen AR, Baker A, Mihalova T, Ingram G, Booth DR, Heard RN, Stewart GJ, Bogaert E, Dubois B, Harbo HF, Celius EG, Spurkland A, Strange R, Hawkins C, Robertson NP, Dudbridge F, Wason J, De Jager PL, Hafler D, Rioux JD, Ivinson AJ, McCauley JL, Pericak-Vance M et al. (2009)
Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor
Eur J Hum Genet, 17 (10), 1309-13
DOI 10.1038/ejhg.2009.41, PubMed 19293837

Harbo HF, Riccio ME, Lorentzen AR, Utsi E, Myhr KM, Mellgren SI, Flåm ST, Thorsby E, Sanchez-Mazas A, Lie BA (2009)
Norwegian Sami differs significantly from other Norwegians according to their HLA profile
Tissue Antigens, 75 (3), 207-17
DOI 10.1111/j.1399-0039.2009.01425.x, PubMed 20047643

Kallio SP, Jakkula E, Purcell S, Suvela M, Koivisto K, Tienari PJ, Elovaara I, Pirttilä T, Reunanen M, Bronnikov D, Viander M, Meri S, Hillert J, Lundmark F, Harbo HF, Lorentzen AR, De Jager PL, Daly MJ, Hafler DA, Palotie A, Peltonen L, Saarela J (2009)
Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS
Hum Mol Genet, 18 (9), 1670-83
DOI 10.1093/hmg/ddp073, PubMed 19221116

Lorentzen AR, Karlsen TH, Olsson M, Smestad C, Mero IL, Woldseth B, Sun JY, Senitzer D, Celius EG, Thorsby E, Spurkland A, Lie BA, Harbo HF (2009)
Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis
Ann Neurol, 65 (6), 658-66
DOI 10.1002/ana.21695, PubMed 19630074

Lorentzen ÅR (2009)
Immunogenetic studies in multiple sclerosis
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 835, 1 b. (flere pag.)
BIBSYS 093635370, ISBN 978-82-8072-340-6

Mero IL, Lorentzen AR, Ban M, Smestad C, Celius EG, Aarseth JH, Myhr KM, Link J, Hillert J, Olsson T, Kockum I, Masterman T, Oturai AB, Søndergaard HB, Sellebjerg F, Saarela J, Kemppinen A, Elovaara I, Spurkland A, Dudbridge F, Lie BA, Harbo HF (2009)
A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis
Eur J Hum Genet, 18 (4), 502-4
DOI 10.1038/ejhg.2009.195, PubMed 19888296

Ockinger J, Stridh P, Beyeen AD, Lundmark F, Seddighzadeh M, Oturai A, Sørensen PS, Lorentzen AR, Celius EG, Leppä V, Koivisto K, Tienari PJ, Alfredsson L, Padyukov L, Hillert J, Kockum I, Jagodic M, Olsson T (2009)
Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis
Genes Immun, 11 (2), 142-54
DOI 10.1038/gene.2009.82, PubMed 19865101

Publications 2008

Lorentzen AR, Smestad C, Lie BA, Oturai AB, Akesson E, Saarela J, Myhr KM, Vartdal F, Celius EG, Sørensen PS, Hillert J, Spurkland A, Harbo HF (2008)
The SH2D2A gene and susceptibility to multiple sclerosis
J Neuroimmunol, 197 (2), 152-8
DOI 10.1016/j.jneuroim.2008.04.037, PubMed 18554728

Publications 2007

Harbo HF, Utsi E, Lorentzen AR, Kampman MT, Celius EG, Myhr KM, Lie BA, Mellgren SI, Thorsby E (2007)
Low frequency of the disease-associated DRB1*15-DQB1*06 haplotype may contribute to the low prevalence of multiple sclerosis in Sami
Tissue Antigens, 69 (4), 299-304
DOI 10.1111/j.1399-0039.2007.00803.x, PubMed 17389012

Smestad C, Brynedal B, Jonasdottir G, Lorentzen AR, Masterman T, Akesson E, Spurkland A, Lie BA, Palmgren J, Celius EG, Hillert J, Harbo HF (2007)
The impact of HLA-A and -DRB1 on age at onset, disease course and severity in Scandinavian multiple sclerosis patients
Eur J Neurol, 14 (8), 835-40
DOI 10.1111/j.1468-1331.2007.01825.x, PubMed 17662002

Publications 2006

Harbo HF, Ekstrøm PO, Lorentzen AR, Sundvold-Gjerstad V, Celius EG, Sawcer S, Spurkland A (2006)
Coding region polymorphisms in T cell signal transduction genes. Prevalence and association to development of multiple sclerosis
J Neuroimmunol, 177 (1-2), 40-5
DOI 10.1016/j.jneuroim.2006.04.021, PubMed 16764945

Publications 2005

Lorentzen AR, Celius EG, Ekstrøm PO, Wiencke K, Lie BA, Myhr KM, Ling V, Thorsby E, Vartdal F, Spurkland A, Harbo HF (2005)
Lack of association with the CD28/CTLA4/ICOS gene region among Norwegian multiple sclerosis patients
J Neuroimmunol, 166 (1-2), 197-201
DOI 10.1016/j.jneuroim.2005.06.002, PubMed 16005527

Publications 2004

Harbo HF, Lie BA, Sawcer S, Celius EG, Dai KZ, Oturai A, Hillert J, Lorentzen AR, Laaksonen M, Myhr KM, Ryder LP, Fredrikson S, Nyland H, Sørensen PS, Sandberg-Wollheim M, Andersen O, Svejgaard A, Edland A, Mellgren SI, Compston A, Vartdal F, Spurkland A (2004)
Genes in the HLA class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis
Tissue Antigens, 63 (3), 237-47
DOI 10.1111/j.0001-2815.2004.00173.x, PubMed 14989713

Smerdel A, Dai KZ, Lorentzen AR, Flatø B, Maslinski S, Thorsby E, Førre Ø, Spurkland A (2004)
Genetic association between juvenile rheumatoid arthritis and polymorphism in the SH2D2A gene
Genes Immun, 5 (4), 310-2
DOI 10.1038/sj.gene.6364093, PubMed 15129233