Publications by Kjetil Tasken

252 publications found

Publications 2019

  1. Brennecke P, Rasina D, Aubi O, Herzog K, Landskron J, Cautain B, Vicente F, Quintana J, Mestres J, Stechmann B, Ellinger B, Brea J, Kolanowski JL, Pilarski R, Orzaez M, Pineda-Lucena A, Laraia L, Nami F, Zielenkiewicz P, Paruch K, Hansen E, von Kries JP, Neuenschwander M, Specker E, Bartunek P et al. (2019)
    EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology
    SLAS Discov, 24 (3), 398-413
    DOI 10.1177/2472555218816276, PubMed 30616481
  2. Chellappa S, Kushekhar K, Munthe LA, Tjønnfjord GE, Aandahl EM, Okkenhaug K, Taskén K (2019)
    The PI3K p110δ Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function
    J Immunol, 202 (5), 1397-1405
    DOI 10.4049/jimmunol.1701703, PubMed 30692213
  3. Dukic AR, Gerbaud P, Guibourdenche J, Thiede B, Taskén K, Pidoux G (2019)
    Correction: Ezrin-anchored PKA phosphorylates serine 369 and 373 on connexin 43 to enhance gap junction assembly, communication, and cell fusion
    Biochem J, 476 (13), 1927
    DOI 10.1042/BCJ-2017-0529_COR, PubMed 31266855
  4. Goodridge JP, Jacobs B, Saetersmoen ML, Clement D, Hammer Q, Clancy T, Skarpen E, Brech A, Landskron J, Grimm C, Pfefferle A, Meza-Zepeda L, Lorenz S, Wiiger MT, Louch WE, Ask EH, Liu LL, Oei VYS, Kjällquist U, Linnarsson S, Patel S, Taskén K, Stenmark H, Malmberg KJ (2019)
    Remodeling of secretory lysosomes during education tunes functional potential in NK cells
    Nat Commun, 10 (1), 514
    DOI 10.1038/s41467-019-08384-x, PubMed 30705279
  5. Skånland SS, Taskén K (2019)
    Carboxyl-Terminal Src Kinase Binds CD28 upon Activation and Mutes Downstream Signaling
    J Immunol, 203 (4), 1055-1063
    DOI 10.4049/jimmunol.1801660, PubMed 31292214
  6. Sukonina V, Ma H, Zhang W, Bartesaghi S, Subhash S, Heglind M, Foyn H, Betz MJ, Nilsson D, Lidell ME, Naumann J, Haufs-Brusberg S, Palmgren H, Mondal T, Beg M, Jedrychowski MP, Taskén K, Pfeifer A, Peng XR, Kanduri C, Enerbäck S (2019)
    FOXK1 and FOXK2 regulate aerobic glycolysis
    Nature, 566 (7743), 279-283
    DOI 10.1038/s41586-019-0900-5, PubMed 30700909

Publications 2018

  1. Dukic AR, Gerbaud P, Guibourdenche J, Thiede B, Taskén K, Pidoux G (2018)
    Ezrin-anchored PKA phosphorylates serine 369 and 373 on connexin 43 to enhance gap junction assembly, communication, and cell fusion
    Biochem J, 475 (2), 455-476
    DOI 10.1042/BCJ20170529, PubMed 29259079
  2. Hermansen JU, Tjønnfjord GE, Munthe LA, Taskén K, Skånland SS (2018)
    Cryopreservation of primary B cells minimally influences their signaling responses
    Sci Rep, 8 (1), 17651
    DOI 10.1038/s41598-018-36121-9, PubMed 30518828
  3. Myhrvold IK, Cremaschi A, Hermansen JU, Tjønnfjord GE, Munthe LA, Taskén K, Skånland SS (2018)
    Single cell profiling of phospho-protein levels in chronic lymphocytic leukemia
    Oncotarget, 9 (10), 9273-9284
    DOI 10.18632/oncotarget.23949, PubMed 29507689
  4. Rogne M, Chu DT, Küntziger TM, Mylonakou MN, Collas P, Tasken K (2018)
    OPA1-anchored PKA phosphorylates perilipin 1 on S522 and S497 in adipocytes differentiated from human adipose stem cells
    Mol Biol Cell, 29 (12), 1487-1501
    DOI 10.1091/mbc.E17-09-0538, PubMed 29688805
  5. Schwab C, Gabrysch A, Olbrich P, Patiño V, Warnatz K, Wolff D, Hoshino A, Kobayashi M, Imai K, Takagi M, Dybedal I, Haddock JA, Sansom DM, Lucena JM, Seidl M, Schmitt-Graeff A, Reiser V, Emmerich F, Frede N, Bulashevska A, Salzer U, Schubert D, Hayakawa S, Okada S, Kanariou M et al. (2018)
    Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects
    J Allergy Clin Immunol, 142 (6), 1932-1946
    DOI 10.1016/j.jaci.2018.02.055, PubMed 29729943
  6. Thimiri Govinda Raj DB, Cremaschi A, Skånland SS, Gade A, Schjesvold FH, Tjønnfjord GE, Munthe LA, Tasken K (2018)
    In-Vitro Drug Sensitivity Screening in Chronic Lymphocytic Leukemia (CLL) Primary Patient Samples Identifies Drug Candidates for Precision Cancer Therapy
    Blood, 132, 4676
    DOI 10.1182/blood-2018-99-110357, PublikaID 304
  7. Thimiri Govinda Raj DB, Giliberto M, Cremaschi A, Skånland SS, Gade A, Tjønnfjord GE, Schjesvold FH, Munthe LA, Tasken K (2018)
    Drug Sensitivity Screening on Multiple Myeloma for Precision Cancer Therapy
    Blood, 132, 4677
    DOI 10.1182/blood-2018-99-110669, PublikaID 303

Publications 2017

  1. Chellappa S, Hugenschmidt H, Hagness M, Subramani S, Melum E, Line PD, Labori KJ, Wiedswang G, Taskén K, Aandahl EM (2017)
    CD8+ T Cells That Coexpress RORγt and T-bet Are Functionally Impaired and Expand in Patients with Distal Bile Duct Cancer
    J Immunol, 198 (4), 1729-1739
    DOI 10.4049/jimmunol.1600061, PubMed 28053236
  2. Chu DT, Tao Y, Taskén K (2017)
    OPA1 in Lipid Metabolism: Function of OPA1 in Lipolysis and Thermogenesis of Adipocytes
    Horm Metab Res, 49 (4), 276-285
    DOI 10.1055/s-0043-100384, PubMed 28427098
  3. Dukic AR, Haugen LH, Pidoux G, Leithe E, Bakke O, Taskén K (2017)
    A protein kinase A-ezrin complex regulates connexin 43 gap junction communication in liver epithelial cells
    Cell Signal, 32, 1-11
    DOI 10.1016/j.cellsig.2017.01.008, PubMed 28077322
  4. Landskron J, Kraggerud SM, Wik E, Dørum A, Bjørnslett M, Melum E, Helland Ø, Bjørge L, Lothe RA, Salvesen HB, Taskén K (2017)
    C77G in PTPRC (CD45) is no risk allele for ovarian cancer, but associated with less aggressive disease
    PLoS One, 12 (7), e0182030
    DOI 10.1371/journal.pone.0182030, PubMed 28759630
  5. Prebensen C, Trøseid M, Ueland T, Dahm A, Sandset PM, Aaberge I, Waalen K, Dyrhol-Riise AM, Taskén K, Kvale D (2017)
    Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: An exploratory clinical trial
    PLoS One, 12 (5), e0176527
    DOI 10.1371/journal.pone.0176527, PubMed 28464042
  6. Taraldsrud E, Fevang B, Jørgensen SF, Moltu K, Hilden V, Taskén K, Aukrust P, Myklebust JH, Olweus J (2017)
    Defective IL-4 signaling in T cells defines severe common variable immunodeficiency
    J Autoimmun, 81, 110-119
    DOI 10.1016/j.jaut.2017.04.004, PubMed 28476239
  7. Wang D, Fløisand Y, Myklebust CV, Bürgler S, Parente-Ribes A, Hofgaard PO, Bogen B, Taskén K, Tjønnfjord GE, Schjesvold F, Dalgaard J, Tveita A, Munthe LA (2017)
    Autologous bone marrow Th cells can support multiple myeloma cell proliferation in vitro and in xenografted mice
    Leukemia, 31 (10), 2114-2121
    DOI 10.1038/leu.2017.69, PubMed 28232741

Publications 2016

  1. Bains SJ, Mahic M, Myklebust TÅ, Småstuen MC, Yaqub S, Dørum LM, Bjørnbeth BA, Møller B, Brudvik KW, Taskén K (2016)
    Reply to M. Løberg et al
    J Clin Oncol, 35 (5), 569-571
    DOI 10.1200/JCO.2016.70.8263, PubMed 29236616
  2. Bains SJ, Mahic M, Myklebust TÅ, Småstuen MC, Yaqub S, Dørum LM, Bjørnbeth BA, Møller B, Brudvik KW, Taskén K (2016)
    Aspirin As Secondary Prevention in Patients With Colorectal Cancer: An Unselected Population-Based Study
    J Clin Oncol, 34 (21), 2501-8
    DOI 10.1200/JCO.2015.65.3519, PubMed 27247217
  3. Bjerregaard-Andersen K, Østensen E, Scott JD, Taskén K, Morth JP (2016)
    Malonate in the nucleotide-binding site traps human AKAP18γ/δ in a novel conformational state
    Acta Crystallogr F Struct Biol Commun, 72 (Pt 8), 591-7
    DOI 10.1107/S2053230X16010189, PubMed 27487922
  4. Dukic AR, McClymont DW, Taskén K (2016)
    A Cell-Based High-Throughput Assay for Gap Junction Communication Suitable for Assessing Connexin 43-Ezrin Interaction Disruptors Using IncuCyte ZOOM
    SLAS Discov, 22 (1), 77-85
    DOI 10.1177/1087057116669120, PubMed 27628689
  5. Landskron J, Taskén K (2016)
    Phosphoprotein Detection by High-Throughput Flow Cytometry
    Methods Mol Biol, 1355, 275-90
    DOI 10.1007/978-1-4939-3049-4_19, PubMed 26584933
  6. Liu LL, Landskron J, Ask EH, Enqvist M, Sohlberg E, Traherne JA, Hammer Q, Goodridge JP, Larsson S, Jayaraman J, Oei VYS, Schaffer M, Taskén K, Ljunggren HG, Romagnani C, Trowsdale J, Malmberg KJ, Béziat V (2016)
    Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans
    Cell Rep, 15 (5), 1088-1099
    DOI 10.1016/j.celrep.2016.04.005, PubMed 27117418
  7. Moltu K, Henjum K, Oberprieler NG, Bjørnbeth BA, Taskén K (2016)
    Proximal signaling responses in peripheral T cells from colorectal cancer patients are affected by high concentrations of circulating prostaglandin E2
    Hum Immunol, 78 (2), 129-137
    DOI 10.1016/j.humimm.2016.10.007, PubMed 27769746
  8. Stiksrud B, Lorvik KB, Kvale D, Mollnes TE, Ueland PM, Trøseid M, Taskén K, Dyrhol-Riise AM (2016)
    Plasma IP-10 Is Increased in Immunological NonResponders and Associated With Activated Regulatory T Cells and Persisting Low CD4 Counts
    J Acquir Immune Defic Syndr, 73 (2), 138-48
    DOI 10.1097/QAI.0000000000001080, PubMed 27632144
  9. Tonby K, Wergeland I, Lieske NV, Kvale D, Tasken K, Dyrhol-Riise AM (2016)
    The COX- inhibitor indomethacin reduces Th1 effector and T regulatory cells in vitro in Mycobacterium tuberculosis infection
    BMC Infect Dis, 16 (1), 599
    DOI 10.1186/s12879-016-1938-8, PubMed 27776487
  10. Wehbi VL, Taskén K (2016)
    Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells - Role of Anchored Protein Kinase A Signaling Units
    Front Immunol, 7, 222
    DOI 10.3389/fimmu.2016.00222, PubMed 27375620

Publications 2015

  1. Calejo AI, Taskén K (2015)
    Targeting protein-protein interactions in complexes organized by A kinase anchoring proteins
    Front Pharmacol, 6, 192
    DOI 10.3389/fphar.2015.00192, PubMed 26441649
  2. Chellappa S, Hugenschmidt H, Hagness M, Line PD, Labori KJ, Wiedswang G, Taskén K, Aandahl EM (2015)
    Regulatory T cells that co-express RORγt and FOXP3 are pro-inflammatory and immunosuppressive and expand in human pancreatic cancer
    Oncoimmunology, 5 (4), e1102828
    DOI 10.1080/2162402X.2015.1102828, PubMed 27141387
  3. Chellappa S, Lieske NV, Hagness M, Line PD, Taskén K, Aandahl EM (2015)
    Human regulatory T cells control TCR signaling and susceptibility to suppression in CD4+ T cells
    J Leukoc Biol, 100 (1), 5-16
    DOI 10.1189/jlb.2HI0815-334R, PubMed 26715685
  4. Gerbaud P, Taskén K, Pidoux G (2015)
    Spatiotemporal regulation of cAMP signaling controls the human trophoblast fusion
    Front Pharmacol, 6, 202
    DOI 10.3389/fphar.2015.00202, PubMed 26441659
  5. Lieske NV, Tonby K, Kvale D, Dyrhol-Riise AM, Tasken K (2015)
    Targeting Tuberculosis and HIV Infection-Specific Regulatory T Cells with MEK/ERK Signaling Pathway Inhibitors
    PLoS One, 10 (11), e0141903
    DOI 10.1371/journal.pone.0141903, PubMed 26544592
  6. Parente-Ribes A, Skånland SS, Bürgler S, Os A, Wang D, Bogen B, Tjønnfjord GE, Taskén K, Munthe LA (2015)
    Spleen tyrosine kinase inhibitors reduce CD40L-induced proliferation of chronic lymphocytic leukemia cells but not normal B cells
    Haematologica, 101 (2), e59-62
    DOI 10.3324/haematol.2015.135590, PubMed 26589914
  7. Pidoux G, Taskén K (2015)
    Anchored PKA as a gatekeeper for gap junctions
    Commun Integr Biol, 8 (4), e1057361
    DOI 10.1080/19420889.2015.1057361, PubMed 26478781
  8. Raslan Z, Magwenzi S, Aburima A, Taskén K, Naseem KM (2015)
    Targeting of type I protein kinase A to lipid rafts is required for platelet inhibition by the 3',5'-cyclic adenosine monophosphate-signaling pathway
    J Thromb Haemost, 13 (9), 1721-34
    DOI 10.1111/jth.13042, PubMed 26176741
  9. Santegoets SJ, Dijkgraaf EM, Battaglia A, Beckhove P, Britten CM, Gallimore A, Godkin A, Gouttefangeas C, de Gruijl TD, Koenen HJ, Scheffold A, Shevach EM, Staats J, Taskén K, Whiteside TL, Kroep JR, Welters MJ, van der Burg SH (2015)
    Monitoring regulatory T cells in clinical samples: consensus on an essential marker set and gating strategy for regulatory T cell analysis by flow cytometry
    Cancer Immunol Immunother, 64 (10), 1271-86
    DOI 10.1007/s00262-015-1729-x, PubMed 26122357

Publications 2014

  1. Ellinger B, Silber J, Prashar A, Landskron J, Weber J, Rehermann S, Müller FJ, Smith S, Wrigley S, Taskén K, Gribbon P, Labes A, Imhoff JF (2014)
    A phenotypic screening approach to identify anticancer compounds derived from marine fungi
    Assay Drug Dev Technol, 12 (3), 162-75
    DOI 10.1089/adt.2013.564, PubMed 24735443
  2. Halvorsen B, Smedbakken LM, Michelsen AE, Skjelland M, Bjerkeli V, Sagen EL, Taskén K, Bendz B, Gullestad L, Holm S, Biessen EA, Aukrust P (2014)
    Activated platelets promote increased monocyte expression of CXCR5 through prostaglandin E2-related mechanisms and enhance the anti-inflammatory effects of CXCL13
    Atherosclerosis, 234 (2), 352-9
    DOI 10.1016/j.atherosclerosis.2014.03.021, PubMed 24732574
  3. Landskron J, Helland Ø, Torgersen KM, Aandahl EM, Gjertsen BT, Bjørge L, Taskén K (2014)
    Activated regulatory and memory T-cells accumulate in malignant ascites from ovarian carcinoma patients
    Cancer Immunol Immunother, 64 (3), 337-47
    DOI 10.1007/s00262-014-1636-6, PubMed 25416072
  4. Pidoux G, Gerbaud P, Dompierre J, Lygren B, Solstad T, Evain-Brion D, Taskén K (2014)
    A PKA-ezrin-Cx43 signaling complex controls gap junction communication and thereby trophoblast cell fusion
    J Cell Sci, 127 (Pt 19), 4172-85
    DOI 10.1242/jcs.149609, PubMed 25052094
  5. Rogne M, Taskén K (2014)
    Compartmentalization of cAMP signaling in adipogenesis, lipogenesis, and lipolysis
    Horm Metab Res, 46 (12), 833-40
    DOI 10.1055/s-0034-1389955, PubMed 25247872
  6. Skånland SS, Moltu K, Berge T, Aandahl EM, Taskén K (2014)
    T-cell co-stimulation through the CD2 and CD28 co-receptors induces distinct signalling responses
    Biochem J, 460 (3), 399-410
    DOI 10.1042/BJ20140040, PubMed 24665965
  7. Spurgeon BE, Aburima A, Oberprieler NG, Taskén K, Naseem KM (2014)
    Multiplexed phosphospecific flow cytometry enables large-scale signaling profiling and drug screening in blood platelets
    J Thromb Haemost, 12 (10), 1733-43
    DOI 10.1111/jth.12670, PubMed 25056834

Publications 2013

  1. Brudvik KW, Bains SJ, Seeberg LT, Labori KJ, Waage A, Taskén K, Aandahl EM, Bjørnbeth BA (2013)
    Aggressive treatment of patients with metastatic colorectal cancer increases survival: a scandinavian single-center experience
    HPB Surg, 2013, 727095
    DOI 10.1155/2013/727095, PubMed 23840074
  2. Cornez I, Joel M, Taskén K, Langmoen IA, Glover JC, Berge T (2013)
    EGF signalling and rapamycin-mediated mTOR inhibition in glioblastoma multiforme evaluated by phospho-specific flow cytometry
    J Neurooncol, 112 (1), 49-57
    DOI 10.1007/s11060-012-1035-9, PubMed 23299461
  3. Landskron J, Taskén K (2013)
    CD147 in regulatory T cells
    Cell Immunol, 282 (1), 17-20
    DOI 10.1016/j.cellimm.2013.04.008, PubMed 23665204
  4. Lone AM, Taskén K (2013)
    Proinflammatory and immunoregulatory roles of eicosanoids in T cells
    Front Immunol, 4, 130
    DOI 10.3389/fimmu.2013.00130, PubMed 23760108
  5. Rogne M, Taskén K (2013)
    Cell signalling analyses in the functional genomics era
    N Biotechnol, 30 (3), 333-8
    DOI 10.1016/j.nbt.2013.01.003, PubMed 23369868
  6. Singh M, Singh P, Vaira D, Torheim EA, Rahmouni S, Taskén K, Moutschen M (2013)
    The RIAD peptidomimetic inhibits HIV-1 replication in humanized NSG mice
    Eur J Clin Invest, 44 (2), 146-52
    DOI 10.1111/eci.12200, PubMed 24283208
  7. Størvold GL, Landskron J, Strozynski M, Arntzen MØ, Koehler CJ, Kalland ME, Taskén K, Thiede B (2013)
    Quantitative profiling of tyrosine phosphorylation revealed changes in the activity of the T cell receptor signaling pathway upon cisplatin-induced apoptosis
    J Proteomics, 91, 344-57
    DOI 10.1016/j.jprot.2013.07.019, PubMed 23933134
  8. Vang T, Landskron J, Viken MK, Oberprieler N, Torgersen KM, Mustelin T, Tasken K, Tautz L, Rickert RC, Lie BA (2013)
    The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses
    Hum Immunol, 74 (5), 574-85
    DOI 10.1016/j.humimm.2012.12.017, PubMed 23333624

Publications 2012

  1. Brudvik KW, Taskén K (2012)
    Modulation of T cell immune functions by the prostaglandin E(2) - cAMP pathway in chronic inflammatory states
    Br J Pharmacol, 166 (2), 411-9
    DOI 10.1111/j.1476-5381.2011.01800.x, PubMed 22141738
  2. Hagness M, Henjum K, Landskron J, Brudvik KW, Bjørnbeth BA, Foss A, Taskén K, Aandahl EM (2012)
    Kinetics and activation requirements of contact-dependent immune suppression by human regulatory T cells
    J Immunol, 188 (11), 5459-66
    DOI 10.4049/jimmunol.1101367, PubMed 22539784
  3. Kalland ME, Solheim SA, Skånland SS, Taskén K, Berge T (2012)
    Modulation of proximal signaling in normal and transformed B cells by transmembrane adapter Cbp/PAG
    Exp Cell Res, 318 (14), 1611-9
    DOI 10.1016/j.yexcr.2012.05.014, PubMed 22659621
  4. Pollheimer J, Bodin J, Sundnes O, Edelmann RJ, Skånland SS, Sponheim J, Brox MJ, Sundlisaeter E, Loos T, Vatn M, Kasprzycka M, Wang J, Küchler AM, Taskén K, Haraldsen G, Hol J (2012)
    Interleukin-33 drives a proinflammatory endothelial activation that selectively targets nonquiescent cells
    Arterioscler Thromb Vasc Biol, 33 (2), e47-55
    DOI 10.1161/ATVBAHA.112.253427, PubMed 23162017
  5. Scott JD, Dessauer CW, Taskén K (2012)
    Creating order from chaos: cellular regulation by kinase anchoring
    Annu Rev Pharmacol Toxicol, 53, 187-210
    DOI 10.1146/annurev-pharmtox-011112-140204, PubMed 23043438
  6. Vang T, Liu WH, Delacroix L, Wu S, Vasile S, Dahl R, Yang L, Musumeci L, Francis D, Landskron J, Tasken K, Tremblay ML, Lie BA, Page R, Mustelin T, Rahmouni S, Rickert RC, Tautz L (2012)
    LYP inhibits T-cell activation when dissociated from CSK
    Nat Chem Biol, 8 (5), 437-46
    DOI 10.1038/nchembio.916, PubMed 22426112

Publications 2011

  1. Andrei M, Bakkebø T, Klaveness J, Taskén K, Undheim K (2011)
    Stereoselective synthesis of (RP)-8-substituted-N⁶-acylated and N⁶-alkylated adenosine-3',5'-cyclic phosphorothioic acids as cAMP antagonists
    Eur J Med Chem, 46 (12), 5935-40
    DOI 10.1016/j.ejmech.2011.10.003, PubMed 22041460
  2. Bjørgo E, Moltu K, Taskén K (2011)
    Phosphodiesterases as targets for modulating T-cell responses
    Handb Exp Pharmacol (204), 345-63
    DOI 10.1007/978-3-642-17969-3_15, PubMed 21695648
  3. Brudvik KW, Henjum K, Aandahl EM, Bjørnbeth BA, Taskén K (2011)
    Regulatory T-cell-mediated inhibition of antitumor immune responses is associated with clinical outcome in patients with liver metastasis from colorectal cancer
    Cancer Immunol Immunother, 61 (7), 1045-53
    DOI 10.1007/s00262-011-1174-4, PubMed 22159472
  4. Brudvik KW, Paulsen JE, Aandahl EM, Roald B, Taskén K (2011)
    Protein kinase A antagonist inhibits β-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in Apc(Min/+) mice
    Mol Cancer, 10, 149
    DOI 10.1186/1476-4598-10-149, PubMed 22168384
  5. Kalland ME, Oberprieler NG, Vang T, Taskén K, Torgersen KM (2011)
    T cell-signaling network analysis reveals distinct differences between CD28 and CD2 costimulation responses in various subsets and in the MAPK pathway between resting and activated regulatory T cells
    J Immunol, 187 (10), 5233-45
    DOI 10.4049/jimmunol.1101804, PubMed 22013130
  6. Means CK, Lygren B, Langeberg LK, Jain A, Dixon RE, Vega AL, Gold MG, Petrosyan S, Taylor SS, Murphy AN, Ha T, Santana LF, Tasken K, Scott JD (2011)
    An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria
    Proc Natl Acad Sci U S A, 108 (48), E1227-35
    DOI 10.1073/pnas.1107182108, PubMed 22084075
  7. Mosenden R, Moltu K, Ruppelt A, Berge T, Taskén K (2011)
    Effects of type I protein kinase A modulation on the T cell distal pole complex
    Scand J Immunol, 74 (6), 568-73
    DOI 10.1111/j.1365-3083.2011.02611.x, PubMed 21854406
  8. Mosenden R, Singh P, Cornez I, Heglind M, Ruppelt A, Moutschen M, Enerbäck S, Rahmouni S, Taskén K (2011)
    Mice with disrupted type I protein kinase A anchoring in T cells resist retrovirus-induced immunodeficiency
    J Immunol, 186 (9), 5119-30
    DOI 10.4049/jimmunol.1100003, PubMed 21430226
  9. Pettersen FO, Torheim EA, Dahm AE, Aaberge IS, Lind A, Holm M, Aandahl EM, Sandset PM, Taskén K, Kvale D (2011)
    An exploratory trial of cyclooxygenase type 2 inhibitor in HIV-1 infection: downregulated immune activation and improved T cell-dependent vaccine responses
    J Virol, 85 (13), 6557-66
    DOI 10.1128/JVI.00073-11, PubMed 21490090
  10. Pidoux G, Witczak O, Jarnæss E, Myrvold L, Urlaub H, Stokka AJ, Küntziger T, Taskén K (2011)
    Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis
    EMBO J, 30 (21), 4371-86
    DOI 10.1038/emboj.2011.365, PubMed 21983901
  11. Solstad T, Bains SJ, Landskron J, Aandahl EM, Thiede B, Taskén K, Torgersen KM (2011)
    CD147 (Basigin/Emmprin) identifies FoxP3+CD45RO+CTLA4+-activated human regulatory T cells
    Blood, 118 (19), 5141-51
    DOI 10.1182/blood-2011-02-339242, PubMed 21937704
  12. Weedon-Fekjær MS, Taskén K (2011)
    Review: Spatiotemporal dynamics of hCG/cAMP signaling and regulation of placental function
    Placenta, 33 Suppl, S87-91
    DOI 10.1016/j.placenta.2011.11.003, PubMed 22103973
  13. Ånensen N, Hjelle SM, Van Belle W, Haaland I, Silden E, Bourdon JC, Hovland R, Taskén K, Knappskog S, Lønning PE, Bruserud Ø, Gjertsen BT (2011)
    Correlation analysis of p53 protein isoforms with NPM1/FLT3 mutations and therapy response in acute myeloid leukemia
    Oncogene, 31 (12), 1533-45
    DOI 10.1038/onc.2011.348, PubMed 21860418

Publications 2010

  1. Bjørgo E, Solheim SA, Abrahamsen H, Baillie GS, Brown KM, Berge T, Okkenhaug K, Houslay MD, Taskén K (2010)
    Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex
    Mol Cell Biol, 30 (7), 1660-72
    DOI 10.1128/MCB.00696-09, PubMed 20086095
  2. Bjørgo E, Taskén K (2010)
    Novel mechanism of signaling by CD28
    Immunol Lett, 129 (1), 1-6
    DOI 10.1016/j.imlet.2010.01.007, PubMed 20123110
  3. Cornez I, Taskén K (2010)
    Spatiotemporal control of cyclic AMP immunomodulation through the PKA-Csk inhibitory pathway is achieved by anchoring to an Ezrin-EBP50-PAG scaffold in effector T cells
    FEBS Lett, 584 (12), 2681-8
    DOI 10.1016/j.febslet.2010.04.056, PubMed 20420835
  4. Mosenden R, Taskén K (2010)
    Cyclic AMP-mediated immune regulation--overview of mechanisms of action in T cells
    Cell Signal, 23 (6), 1009-16
    DOI 10.1016/j.cellsig.2010.11.018, PubMed 21130867
  5. Ndhlovu LC, Leal FE, Eccles-James IG, Jha AR, Lanteri M, Norris PJ, Barbour JD, Wachter DJ, Andersson J, Taskén K, Torheim EA, Aandahl EM, Kallas EG, Nixon DF (2010)
    A novel human CD4+ T-cell inducer subset with potent immunostimulatory properties
    Eur J Immunol, 40 (1), 134-41
    DOI 10.1002/eji.200939258, PubMed 19877008
  6. Oberprieler NG, Lemeer S, Kalland ME, Torgersen KM, Heck AJ, Taskén K (2010)
    High-resolution mapping of prostaglandin E2-dependent signaling networks identifies a constitutively active PKA signaling node in CD8+CD45RO+ T cells
    Blood, 116 (13), 2253-65
    DOI 10.1182/blood-2010-01-266650, PubMed 20558615
  7. Oberprieler NG, Taskén K (2010)
    Analysing phosphorylation-based signalling networks by phospho flow cytometry
    Cell Signal, 23 (1), 14-8
    DOI 10.1016/j.cellsig.2010.07.009, PubMed 20643206
  8. Pettersen FO, Taskén K, Kvale D (2010)
    Combined Env- and Gag-specific T cell responses in relation to programmed death-1 receptor and CD4 T cell loss rates in human immunodeficiency virus-1 infection
    Clin Exp Immunol, 161 (2), 315-23
    DOI 10.1111/j.1365-2249.2010.04179.x, PubMed 20491784
  9. Pidoux G, Taskén K (2010)
    Specificity and spatial dynamics of protein kinase A signaling organized by A-kinase-anchoring proteins
    J Mol Endocrinol, 44 (5), 271-84
    DOI 10.1677/JME-10-0010, PubMed 20150326
  10. Solstad T, Bjørgo E, Koehler CJ, Strozynski M, Torgersen KM, Taskén K, Thiede B (2010)
    Quantitative proteome analysis of detergent-resistant membranes identifies the differential regulation of protein kinase C isoforms in apoptotic T cells
    Proteomics, 10 (15), 2758-68
    DOI 10.1002/pmic.201000164, PubMed 20486122
  11. Soond DR, Bjørgo E, Moltu K, Dale VQ, Patton DT, Torgersen KM, Galleway F, Twomey B, Clark J, Gaston JS, Taskén K, Bunyard P, Okkenhaug K (2010)
    PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans
    Blood, 115 (11), 2203-13
    DOI 10.1182/blood-2009-07-232330, PubMed 20081091

Publications 2009

  1. Jarnaess E, Stokka AJ, Kvissel AK, Skålhegg BS, Torgersen KM, Scott JD, Carlson CR, Taskén K (2009)
    Splicing factor arginine/serine-rich 17A (SFRS17A) is an A-kinase anchoring protein that targets protein kinase A to splicing factor compartments
    J Biol Chem, 284 (50), 35154-64
    DOI 10.1074/jbc.M109.056465, PubMed 19840947
  2. Ngai J, Inngjerdingen M, Berge T, Taskén K (2009)
    Interplay between the heterotrimeric G-protein subunits Galphaq and Galphai2 sets the threshold for chemotaxis and TCR activation
    BMC Immunol, 10, 27
    DOI 10.1186/1471-2172-10-27, PubMed 19426503
  3. Stokka AJ, Mosenden R, Ruppelt A, Lygren B, Taskén K (2009)
    The adaptor protein EBP50 is important for localization of the protein kinase A-Ezrin complex in T-cells and the immunomodulating effect of cAMP
    Biochem J, 425 (2), 381-8
    DOI 10.1042/BJ20091136, PubMed 19857202
  4. Taskén K (2009)
    Waking up regulatory T cells
    Blood, 114 (6), 1136-7
    DOI 10.1182/blood-2009-06-223222, PubMed 19661275
  5. Torheim EA, Jarnaess E, Lygren B, Taskén K (2009)
    Design of proteolytically stable RI-anchoring disruptor peptidomimetics for in vivo studies of anchored type I protein kinase A-mediated signalling
    Biochem J, 424 (1), 69-78
    DOI 10.1042/BJ20090933, PubMed 19715558
  6. Torheim EA, Ndhlovu LC, Pettersen FO, Larsen TL, Jha AR, Torgersen KM, Kvale D, Nixon DF, Taskén K, Aandahl EM (2009)
    Interleukin-10-secreting T cells define a suppressive subset within the HIV-1-specific T-cell population
    Eur J Immunol, 39 (5), 1280-7
    DOI 10.1002/eji.200839002, PubMed 19384871

Publications 2008

  1. Berg T, Degerman E, Tasken K (2008)
    Increased cAMP signaling can ameliorate the hypertensive condition in spontaneously hypertensive rats
    J Vasc Res, 46 (1), 25-35
    DOI 10.1159/000135662, PubMed 18515972
  2. Bryn T, Mahic M, Aandahl EM, Frøland SS, Aukrust P, Taskén K (2008)
    Inhibition of protein kinase A improves effector function of monocytes from HIV-infected patients
    AIDS Res Hum Retroviruses, 24 (7), 1013-5
    DOI 10.1089/aid.2008.0071, PubMed 18593346
  3. Jarnaess E, Ruppelt A, Stokka AJ, Lygren B, Scott JD, Taskén K (2008)
    Dual specificity A-kinase anchoring proteins (AKAPs) contain an additional binding region that enhances targeting of protein kinase A type I
    J Biol Chem, 283 (48), 33708-18
    DOI 10.1074/jbc.M804807200, PubMed 18824551
  4. Larsen KO, Lygren B, Sjaastad I, Krobert KA, Arnkvaern K, Florholmen G, Larsen AK, Levy FO, Taskén K, Skjønsberg OH, Christensen G (2008)
    Diastolic dysfunction in alveolar hypoxia: a role for interleukin-18-mediated increase in protein phosphatase 2A
    Cardiovasc Res, 80 (1), 47-54
    DOI 10.1093/cvr/cvn180, PubMed 18599478
  5. Lygren B, Taskén K (2008)
    The potential use of AKAP18delta as a drug target in heart failure patients
    Expert Opin Biol Ther, 8 (8), 1099-108
    DOI 10.1517/14712598.8.8.1099, PubMed 18613762
  6. Mahic M, Henjum K, Yaqub S, Bjørnbeth BA, Torgersen KM, Taskén K, Aandahl EM (2008)
    Generation of highly suppressive adaptive CD8(+)CD25(+)FOXP3(+) regulatory T cells by continuous antigen stimulation
    Eur J Immunol, 38 (3), 640-6
    DOI 10.1002/eji.200737529, PubMed 18266270
  7. Mahic M, Kalland ME, Aandahl EM, Torgersen KM, Taskén K (2008)
    Human naturally occurring and adaptive regulatory T cells secrete high levels of leukaemia inhibitory factor upon activation
    Scand J Immunol, 68 (4), 391-6
    DOI 10.1111/j.1365-3083.2008.02148.x, PubMed 18782268
  8. Mahic M, Yaqub S, Bryn T, Henjum K, Eide DM, Torgersen KM, Aandahl EM, Taskén K (2008)
    Differentiation of naive CD4+ T cells into CD4+CD25+FOXP3+ regulatory T cells by continuous antigen stimulation
    J Leukoc Biol, 83 (5), 1111-7
    DOI 10.1189/jlb.0507329, PubMed 18270250
  9. Methi T, Berge T, Torgersen KM, Taskén K (2008)
    Reduced Cbl phosphorylation and degradation of the zeta-chain of the T-cell receptor/CD3 complex in T cells with low Lck levels
    Eur J Immunol, 38 (9), 2557-63
    DOI 10.1002/eji.200737837, PubMed 18792408
  10. Ngai J, Methi T, Andressen KW, Levy FO, Torgersen KM, Vang T, Wettschureck N, Taskén K (2008)
    The heterotrimeric G-protein alpha-subunit Galphaq regulates TCR-mediated immune responses through an Lck-dependent pathway
    Eur J Immunol, 38 (11), 3208-18
    DOI 10.1002/eji.200838195, PubMed 18991294
  11. Rogne M, Stokka AJ, Taskén K, Collas P, Küntziger T (2008)
    Mutually exclusive binding of PP1 and RNA to AKAP149 affects the mitochondrial network
    Hum Mol Genet, 18 (5), 978-87
    DOI 10.1093/hmg/ddn425, PubMed 19074462
  12. Solheim SA, Petsalaki E, Stokka AJ, Russell RB, Taskén K, Berge T (2008)
    Interactions between the Fyn SH3-domain and adaptor protein Cbp/PAG derived ligands, effects on kinase activity and affinity
    FEBS J, 275 (19), 4863-74
    DOI 10.1111/j.1742-4658.2008.06626.x, PubMed 18721137
  13. Torgersen KM, Aandahl EM, Taskén K (2008)
    Molecular architecture of signal complexes regulating immune cell function
    Handb Exp Pharmacol (186), 327-63
    DOI 10.1007/978-3-540-72843-6_14, PubMed 18491059
  14. Yaqub S, Taskén K (2008)
    Role for the cAMP-protein kinase A signaling pathway in suppression of antitumor immune responses by regulatory T cells
    Crit Rev Oncog, 14 (1), 57-77
    PubMed 19105570
  15. Aandahl EM, Torgersen KM, Taskén K (2008)
    CD8+ regulatory T cells-A distinct T-cell lineage or a transient T-cell phenotype?
    Hum Immunol, 69 (11), 696-9
    DOI 10.1016/j.humimm.2008.08.291, PubMed 18817824

Publications 2007

  1. Andrei M, Bjørnstad V, Langli G, Rømming C, Klaveness J, Taskén K, Undheim K (2007)
    Stereoselective preparation of (RP)-8-hetaryladenosine-3',5'-cyclic phosphorothioic acids
    Org Biomol Chem, 5 (13), 2070-80
    DOI 10.1039/b702403g, PubMed 17581650
  2. Bryn T, Yaqub S, Mahic M, Henjum K, Aandahl EM, Taskén K (2007)
    LPS-activated monocytes suppress T-cell immune responses and induce FOXP3+ T cells through a COX-2-PGE2-dependent mechanism
    Int Immunol, 20 (2), 235-45
    DOI 10.1093/intimm/dxm134, PubMed 18156149
  3. Jarnaess E, Taskén K (2007)
    Spatiotemporal control of cAMP signalling processes by anchored signalling complexes
    Biochem Soc Trans, 35 (Pt 5), 931-7
    DOI 10.1042/BST0350931, PubMed 17956249
  4. Kesti T, Ruppelt A, Wang JH, Liss M, Wagner R, Taskén K, Saksela K (2007)
    Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon
    J Immunol, 179 (2), 878-85
    DOI 10.4049/jimmunol.179.2.878, PubMed 17617578
  5. Lygren B, Carlson CR, Santamaria K, Lissandron V, McSorley T, Litzenberg J, Lorenz D, Wiesner B, Rosenthal W, Zaccolo M, Taskén K, Klussmann E (2007)
    AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum
    EMBO Rep, 8 (11), 1061-7
    DOI 10.1038/sj.embor.7401081, PubMed 17901878
  6. Methi T, Ngai J, Vang T, Torgersen KM, Taskén K (2007)
    Hypophosphorylated TCR/CD3zeta signals through a Grb2-SOS1-Ras pathway in Lck knockdown cells
    Eur J Immunol, 37 (9), 2539-48
    DOI 10.1002/eji.200636973, PubMed 17683112
  7. Ruppelt A, Mosenden R, Grönholm M, Aandahl EM, Tobin D, Carlson CR, Abrahamsen H, Herberg FW, Carpén O, Taskén K (2007)
    Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin
    J Immunol, 179 (8), 5159-68
    DOI 10.4049/jimmunol.179.8.5159, PubMed 17911601
  8. Solheim SA, Torgersen KM, Taskén K, Berge T (2007)
    Regulation of FynT function by dual domain docking on PAG/Cbp
    J Biol Chem, 283 (5), 2773-83
    DOI 10.1074/jbc.M705215200, PubMed 18056706
  9. Yaqub S, Henjum K, Mahic M, Jahnsen FL, Aandahl EM, Bjørnbeth BA, Taskén K (2007)
    Regulatory T cells in colorectal cancer patients suppress anti-tumor immune activity in a COX-2 dependent manner
    Cancer Immunol Immunother, 57 (6), 813-21
    DOI 10.1007/s00262-007-0417-x, PubMed 17962941

Publications 2006

  1. Bjørgo E, Taskén K (2006)
    Role of cAMP phosphodiesterase 4 in regulation of T-cell function
    Crit Rev Immunol, 26 (5), 443-51
    PubMed 17341187
  2. Bryn T, Mahic M, Enserink JM, Schwede F, Aandahl EM, Taskén K (2006)
    The cyclic AMP-Epac1-Rap1 pathway is dissociated from regulation of effector functions in monocytes but acquires immunoregulatory function in mature macrophages
    J Immunol, 176 (12), 7361-70
    DOI 10.4049/jimmunol.176.12.7361, PubMed 16751380
  3. Carlson CR, Lygren B, Berge T, Hoshi N, Wong W, Taskén K, Scott JD (2006)
    Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor
    J Biol Chem, 281 (30), 21535-45
    DOI 10.1074/jbc.M603223200, PubMed 16728392
  4. Damås JK, Smith C, Øie E, Fevang B, Halvorsen B, Waehre T, Boullier A, Breland U, Yndestad A, Ovchinnikova O, Robertson AK, Sandberg WJ, Kjekshus J, Taskén K, Frøland SS, Gullestad L, Hansson GK, Quehenberger O, Aukrust P (2006)
    Enhanced expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental atherosclerosis: possible pathogenic role in plaque destabilization
    Arterioscler Thromb Vasc Biol, 27 (3), 614-20
    DOI 10.1161/01.ATV.0000255581.38523.7c, PubMed 17170367
  5. Gold MG, Lygren B, Dokurno P, Hoshi N, McConnachie G, Taskén K, Carlson CR, Scott JD, Barford D (2006)
    Molecular basis of AKAP specificity for PKA regulatory subunits
    Mol Cell, 24 (3), 383-95
    DOI 10.1016/j.molcel.2006.09.006, PubMed 17081989
  6. Grønning LM, Baillie GS, Cederberg A, Lynch MJ, Houslay MD, Enerbäck S, Taskén K (2006)
    Reduced PDE4 expression and activity contributes to enhanced catecholamine-induced cAMP accumulation in adipocytes from FOXC2 transgenic mice
    FEBS Lett, 580 (17), 4126-30
    DOI 10.1016/j.febslet.2006.06.058, PubMed 16828089
  7. Kvale D, Ormaasen V, Kran AM, Johansson CC, Aukrust P, Aandahl EM, Frøland SS, Taskén K (2006)
    Immune modulatory effects of cyclooxygenase type 2 inhibitors in HIV patients on combination antiretroviral treatment
    AIDS, 20 (6), 813-20
    DOI 10.1097/01.aids.0000218544.54586.f1, PubMed 16549964
  8. Lygren B, Taskén K (2006)
    Compartmentalized cAMP signalling is important in the regulation of Ca(2+) cycling in the heart
    Biochem Soc Trans, 34 (Pt 4), 489-91
    DOI 10.1042/BST0340489, PubMed 16856840
  9. Mahic M, Yaqub S, Johansson CC, Taskén K, Aandahl EM (2006)
    FOXP3+CD4+CD25+ adaptive regulatory T cells express cyclooxygenase-2 and suppress effector T cells by a prostaglandin E2-dependent mechanism
    J Immunol, 177 (1), 246-54
    DOI 10.4049/jimmunol.177.1.246, PubMed 16785520
  10. Stokka AJ, Gesellchen F, Carlson CR, Scott JD, Herberg FW, Taskén K (2006)
    Characterization of A-kinase-anchoring disruptors using a solution-based assay
    Biochem J, 400 (3), 493-9
    DOI 10.1042/BJ20060962, PubMed 16948636
  11. Tasken K, Ruppelt A (2006)
    Negative regulation of T-cell receptor activation by the cAMP-PKA-Csk signalling pathway in T-cell lipid rafts
    Front Biosci, 11, 2929-39
    DOI 10.2741/2022, PubMed 16720365
  12. Taskén K, Stokka AJ (2006)
    The molecular machinery for cAMP-dependent immunomodulation in T-cells
    Biochem Soc Trans, 34 (Pt 4), 476-9
    DOI 10.1042/BST0340476, PubMed 16856837

Publications 2005

  1. Lygren B, Taskén K, Carlson CR (2005)
    A fast and sensitive method for isolation of detergent-resistant membranes from T cells
    J Immunol Methods, 305 (2), 199-205
    DOI 10.1016/j.jim.2005.06.011, PubMed 16176818
  2. McCahill A, McSorley T, Huston E, Hill EV, Lynch MJ, Gall I, Keryer G, Lygren B, Tasken K, van Heeke G, Houslay MD (2005)
    In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region
    Cell Signal, 17 (9), 1158-73
    DOI 10.1016/j.cellsig.2005.04.003, PubMed 15905070
  3. Methi T, Ngai J, Mahic M, Amarzguioui M, Vang T, Tasken K (2005)
    Short-interfering RNA-mediated Lck knockdown results in augmented downstream T cell responses
    J Immunol, 175 (11), 7398-406
    DOI 10.4049/jimmunol.175.11.7398, PubMed 16301647
  4. Vang T, Congia M, Macis MD, Musumeci L, Orrú V, Zavattari P, Nika K, Tautz L, Taskén K, Cucca F, Mustelin T, Bottini N (2005)
    Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant
    Nat Genet, 37 (12), 1317-9
    DOI 10.1038/ng1673, PubMed 16273109
  5. Wong L, Lieser SA, Miyashita O, Miller M, Tasken K, Onuchic JN, Adams JA, Woods VL, Jennings PA (2005)
    Coupled motions in the SH2 and kinase domains of Csk control Src phosphorylation
    J Mol Biol, 351 (1), 131-43
    DOI 10.1016/j.jmb.2005.05.042, PubMed 16002086
  6. Zeddou M, Greimers R, de Valensart N, Nayjib B, Tasken K, Boniver J, Moutschen M, Rahmouni S (2005)
    Prostaglandin E2 induces the expression of functional inhibitory CD94/NKG2A receptors in human CD8+ T lymphocytes by a cAMP-dependent protein kinase A type I pathway
    Biochem Pharmacol, 70 (5), 714-24
    DOI 10.1016/j.bcp.2005.05.015, PubMed 15978547

Publications 2004

  1. Abrahamsen H, Baillie G, Ngai J, Vang T, Nika K, Ruppelt A, Mustelin T, Zaccolo M, Houslay M, Taskén K (2004)
    TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling
    J Immunol, 173 (8), 4847-58
    DOI 10.4049/jimmunol.173.8.4847, PubMed 15470025
  2. Enserink JM, Price LS, Methi T, Mahic M, Sonnenberg A, Bos JL, Taskén K (2004)
    The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin
    J Biol Chem, 279 (43), 44889-96
    DOI 10.1074/jbc.M404599200, PubMed 15302884
  3. Johansson CC, Bryn T, Yndestad A, Eiken HG, Bjerkeli V, Frøland SS, Aukrust P, Taskén K (2004)
    Cytokine networks are pre-activated in T cells from HIV-infected patients on HAART and are under the control of cAMP
    AIDS, 18 (2), 171-9
    DOI 10.1097/00002030-200401230-00005, PubMed 15075533
  4. Johansson CC, Bryn T, Aandahl EM, Areklett MA, Aukrust P, Taskén K, Frøland SS (2004)
    Treatment with type-2 selective and non-selective cyclooxygenase inhibitors improves T-cell proliferation in HIV-infected patients on highly active antiretroviral therapy
    AIDS, 18 (6), 951-2
    DOI 10.1097/00002030-200404090-00015, PubMed 15060445
  5. Johansson CC, Yndestad A, Enserink JM, Ree AH, Aukrust P, Taskén K (2004)
    The epidermal growth factor-like growth factor amphiregulin is strongly induced by the adenosine 3',5'-monophosphate pathway in various cell types
    Endocrinology, 145 (11), 5177-84
    DOI 10.1210/en.2004-0232, PubMed 15284208
  6. Nika K, Hyunh H, Williams S, Paul S, Bottini N, Taskén K, Lombroso PJ, Mustelin T (2004)
    Haematopoietic protein tyrosine phosphatase (HePTP) phosphorylation by cAMP-dependent protein kinase in T-cells: dynamics and subcellular location
    Biochem J, 378 (Pt 2), 335-42
    DOI 10.1042/BJ20031244, PubMed 14613483
  7. Rahmouni S, Aandahl EM, Nayjib B, Zeddou M, Giannini S, Verlaet M, Greimers R, Boniver J, Tasken K, Moutschen M (2004)
    Cyclo-oxygenase type 2-dependent prostaglandin E2 secretion is involved in retrovirus-induced T-cell dysfunction in mice
    Biochem J, 384 (Pt 3), 469-76
    DOI 10.1042/BJ20031859, PubMed 15344910
  8. Taskén K, Aandahl EM (2004)
    Localized effects of cAMP mediated by distinct routes of protein kinase A
    Physiol Rev, 84 (1), 137-67
    DOI 10.1152/physrev.00021.2003, PubMed 14715913
  9. Vang T, Abrahamsen H, Myklebust S, Enserink J, Prydz H, Mustelin T, Amarzguioui M, Tasken K (2004)
    Knockdown of C-terminal Src kinase by siRNA-mediated RNA interference augments T cell receptor signaling in mature T cells
    Eur J Immunol, 34 (8), 2191-9
    DOI 10.1002/eji.200425036, PubMed 15259016
  10. Waehre T, Damås JK, Yndestad A, Taskén K, Pedersen TM, Smith C, Halvorsen B, Frøland SS, Solum NO, Aukrust P (2004)
    Effect of activated platelets on expression of cytokines in peripheral blood mononuclear cells - potential role of prostaglandin E2
    Thromb Haemost, 92 (6), 1358-67
    DOI 10.1160/TH04-03-0146, PubMed 15583745

Publications 2003

  1. Abrahamsen H, Vang T, Taskén K (2003)
    Protein kinase A intersects SRC signaling in membrane microdomains
    J Biol Chem, 278 (19), 17170-7
    DOI 10.1074/jbc.M211426200, PubMed 12606547
  2. Carlson CR, Ruppelt A, Taskén K (2003)
    A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system
    J Mol Biol, 327 (3), 609-18
    DOI 10.1016/s0022-2836(03)00093-7, PubMed 12634056
  3. Eide T, Taskén KA, Carlson C, Williams G, Jahnsen T, Taskén K, Collas P (2003)
    Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication
    J Biol Chem, 278 (29), 26750-6
    DOI 10.1074/jbc.M300765200, PubMed 12740381
  4. Grönholm M, Vossebein L, Carlson CR, Kuja-Panula J, Teesalu T, Alfthan K, Vaheri A, Rauvala H, Herberg FW, Taskén K, Carpén O (2003)
    Merlin links to the cAMP neuronal signaling pathway by anchoring the RIbeta subunit of protein kinase A
    J Biol Chem, 278 (42), 41167-72
    DOI 10.1074/jbc.M306149200, PubMed 12896975
  5. Holm AM, Aukrust P, Aandahl EM, Müller F, Taskén K, Frøland SS (2003)
    Impaired secretion of IL-10 by T cells from patients with common variable immunodeficiency--involvement of protein kinase A type I
    J Immunol, 170 (11), 5772-7
    DOI 10.4049/jimmunol.170.11.5772, PubMed 12759461
  6. Johansson CC, Dahle MK, Blomqvist SR, Grønning LM, Aandahl EM, Enerbäck S, Taskén K (2003)
    A winged helix forkhead (FOXD2) tunes sensitivity to cAMP in T lymphocytes through regulation of cAMP-dependent protein kinase RIalpha
    J Biol Chem, 278 (19), 17573-9
    DOI 10.1074/jbc.M300311200, PubMed 12621056
  7. Keryer G, Witczak O, Delouvée A, Kemmner WA, Rouillard D, Tasken K, Bornens M (2003)
    Dissociating the centrosomal matrix protein AKAP450 from centrioles impairs centriole duplication and cell cycle progression
    Mol Biol Cell, 14 (6), 2436-46
    DOI 10.1091/mbc.e02-09-0614, PubMed 12808041
  8. Mustelin T, Taskén K (2003)
    Positive and negative regulation of T-cell activation through kinases and phosphatases
    Biochem J, 371 (Pt 1), 15-27
    DOI 10.1042/BJ20021637, PubMed 12485116
  9. Vang T, Abrahamsen H, Myklebust S, Horejsí V, Taskén K (2003)
    Combined spatial and enzymatic regulation of Csk by cAMP and protein kinase a inhibits T cell receptor signaling
    J Biol Chem, 278 (20), 17597-600
    DOI 10.1074/jbc.C300077200, PubMed 12665526
  10. Yaqub S, Abrahamsen H, Zimmerman B, Kholod N, Torgersen KM, Mustelin T, Herberg FW, Taskén K, Vang T (2003)
    Activation of C-terminal Src kinase (Csk) by phosphorylation at serine-364 depends on the Csk-Src homology 3 domain
    Biochem J, 372 (Pt 1), 271-8
    DOI 10.1042/BJ20030021, PubMed 12600271
  11. Yaqub S, Solhaug V, Vang T, Solberg R, Aasen A, Taskén K, Wang JE (2003)
    A human whole blood model of LPS-mediated suppression of T cell activation
    Med Sci Monit, 9 (3), BR120-6
    PubMed 12640334
  12. Aandahl EM, Sandberg JK, Beckerman KP, Taskén K, Moretto WJ, Nixon DF (2003)
    CD7 is a differentiation marker that identifies multiple CD8 T cell effector subsets
    J Immunol, 170 (5), 2349-55
    DOI 10.4049/jimmunol.170.5.2349, PubMed 12594257

Publications 2002

  1. Birkeli KA, Llorente A, Torgersen ML, Keryer G, Taskén K, Sandvig K (2002)
    Endosome-to-Golgi transport is regulated by protein kinase A type II alpha
    J Biol Chem, 278 (3), 1991-7
    DOI 10.1074/jbc.M209982200, PubMed 12419802
  2. Dahle MK, Grønning LM, Cederberg A, Blomhoff HK, Miura N, Enerbäck S, Taskén KA, Taskén K (2002)
    Mechanisms of FOXC2- and FOXD1-mediated regulation of the RI alpha subunit of cAMP-dependent protein kinase include release of transcriptional repression and activation by protein kinase B alpha and cAMP
    J Biol Chem, 277 (25), 22902-8
    DOI 10.1074/jbc.M200131200, PubMed 11943768
  3. Dahle MK, Taskén K, Taskén KA (2002)
    USF2 inhibits C/EBP-mediated transcriptional regulation of the RIIbeta subunit of cAMP-dependent protein kinase
    BMC Mol Biol, 3, 10
    DOI 10.1186/1471-2199-3-10, PubMed 12086590
  4. Eide T, Carlson C, Taskén KA, Hirano T, Taskén K, Collas P (2002)
    Distinct but overlapping domains of AKAP95 are implicated in chromosome condensation and condensin targeting
    EMBO Rep, 3 (5), 426-32
    DOI 10.1093/embo-reports/kvf089, PubMed 11964380
  5. Grønning LM, Cederberg A, Miura N, Enerbäck S, Taskén K (2002)
    Insulin and TNF alpha induce expression of the forkhead transcription factor gene Foxc2 in 3T3-L1 adipocytes via PI3K and ERK 1/2-dependent pathways
    Mol Endocrinol, 16 (4), 873-83
    DOI 10.1210/mend.16.4.0803, PubMed 11923482
  6. Hoover F, Kalhovde JM, Dahle MK, Skålhegg B, Taskén K, Lømo T (2002)
    Electrical muscle activity pattern and transcriptional and posttranscriptional mechanisms regulate PKA subunit expression in rat skeletal muscle
    Mol Cell Neurosci, 19 (2), 125-37
    DOI 10.1006/mcne.2001.1053, PubMed 11860267
  7. Torgersen KM, Vang T, Abrahamsen H, Yaqub S, Taskén K (2002)
    Molecular mechanisms for protein kinase A-mediated modulation of immune function
    Cell Signal, 14 (1), 1-9
    DOI 10.1016/S0898-6568(01)00214-5, PubMed 11747983
  8. Aandahl EM, Moretto WJ, Haslett PA, Vang T, Bryn T, Tasken K, Nixon DF (2002)
    Inhibition of antigen-specific T cell proliferation and cytokine production by protein kinase A type I
    J Immunol, 169 (2), 802-8
    DOI 10.4049/jimmunol.169.2.802, PubMed 12097383

Publications 2001

  1. Carlson CR, Witczak O, Vossebein L, Labbé JC, Skålhegg BS, Keryer G, Herberg FW, Collas P, Taskén K (2001)
    CDK1-mediated phosphorylation of the RIIalpha regulatory subunit of PKA works as a molecular switch that promotes dissociation of RIIalpha from centrosomes at mitosis
    J Cell Sci, 114 (Pt 18), 3243-54
    PubMed 11591813
  2. Cederberg A, Grønning LM, Ahrén B, Taskén K, Carlsson P, Enerbäck S (2001)
    FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance
    Cell, 106 (5), 563-73
    DOI 10.1016/s0092-8674(01)00474-3, PubMed 11551504
  3. Dahle MK, Knutsen HK, Taskén KA, Pilz R, Taskén K (2001)
    Cyclic AMP regulates expression of the RI alpha subunit of cAMP-dependent protein kinase through an alternatively spliced 5' UTR
    Eur J Biochem, 268 (22), 5920-9
    DOI 10.1046/j.0014-2956.2001.02542.x, PubMed 11722580
  4. Dahle MK, Reinton N, Orstavik S, Taskén KA, Taskén K (2001)
    Novel alternatively spliced mRNA (1c) of the protein kinase A RIα subunit is implicated in haploid germ cell specific expression
    Mol Reprod Dev, 59 (1), 11-6
    DOI 10.1002/mrd.1001, PubMed 11335941
  5. Fax P, Carlson CR, Collas P, Taskén K, Esche H, Brockmann D (2001)
    Binding of PKA-RIIalpha to the Adenovirus E1A12S oncoprotein correlates with its nuclear translocation and an increase in PKA-dependent promoter activity
    Virology, 285 (1), 30-41
    DOI 10.1006/viro.2001.0926, PubMed 11414803
  6. Hoover F, Mathiesen I, Skålhegg BS, Lømo T, Taskén K (2001)
    Differential expression and regulation of the PKA signalling pathway in fast and slow skeletal muscle
    Anat Embryol (Berl), 203 (3), 193-201
    DOI 10.1007/s004290000155, PubMed 11303905
  7. Landsverk HB, Carlson CR, Steen RL, Vossebein L, Herberg FW, Taskén K, Collas P (2001)
    Regulation of anchoring of the RIIalpha regulatory subunit of PKA to AKAP95 by threonine phosphorylation of RIIalpha: implications for chromosome dynamics at mitosis
    J Cell Sci, 114 (Pt 18), 3255-64
    PubMed 11591814
  8. Li H, Degenhardt B, Tobin D, Yao ZX, Tasken K, Papadopoulos V (2001)
    Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein
    Mol Endocrinol, 15 (12), 2211-28
    DOI 10.1210/mend.15.12.0736, PubMed 11731621
  9. Rahmouni S, Aandahl EM, Trebak M, Boniver J, Taskén K, Moutschen M (2001)
    Increased cAMP levels and protein kinase (PKA) type I activation in CD4+ T cells and B cells contribute to retrovirus-induced immunodeficiency of mice (MAIDS): a useful in vivo model for drug testing
    FASEB J, 15 (8), 1466-8
    DOI 10.1096/fj.00-0813fje, PubMed 11387259
  10. Taskén KA, Collas P, Kemmner WA, Witczak O, Conti M, Taskén K (2001)
    Phosphodiesterase 4D and protein kinase a type II constitute a signaling unit in the centrosomal area
    J Biol Chem, 276 (25), 21999-2002
    DOI 10.1074/jbc.C000911200, PubMed 11285255
  11. Torgersen KM, Vang T, Abrahamsen H, Yaqub S, Horejsí V, Schraven B, Rolstad B, Mustelin T, Taskén K (2001)
    Release from tonic inhibition of T cell activation through transient displacement of C-terminal Src kinase (Csk) from lipid rafts
    J Biol Chem, 276 (31), 29313-8
    DOI 10.1074/jbc.C100014200, PubMed 11390365
  12. Torgersen KM, Vaage JT, Rolstad B, Taskén K (2001)
    A soluble LAT deletion mutant inhibits T-cell activation: reduced recruitment of signalling molecules to glycolipid-enriched microdomains
    Cell Signal, 13 (3), 213-20
    DOI 10.1016/S0898-6568(01)00131-0, PubMed 11282460
  13. Vang T, Torgersen KM, Sundvold V, Saxena M, Levy FO, Skålhegg BS, Hansson V, Mustelin T, Taskén K (2001)
    Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor
    J Exp Med, 193 (4), 497-507
    DOI 10.1084/jem.193.4.497, PubMed 11181701

Publications 2000

  1. Grønning LM, Wang JE, Ree AH, Haugen TB, Taskén K, Taskén KA (2000)
    Regulation of tissue inhibitor of metalloproteinases-1 in rat Sertoli cells: induction by germ cell residual bodies, interleukin-1alpha, and second messengers
    Biol Reprod, 62 (4), 1040-6
    DOI 10.1095/biolreprod62.4.1040, PubMed 10727275
  2. Hansson V, Skalhegg BS, Tasken K (2000)
    Cyclic-AMP-dependent protein kinase (PKA) in testicular cells. Cell specific expression, differential regulation and targeting of subunits of PKA
    J Steroid Biochem Mol Biol, 73 (1-2), 81-92
    PubMed 10822028
  3. Hansson V, Skalhegg BS, Tasken K (2000)
    Cyclic-AMP-dependent protein kinase (PKA) in testicular cells. Cell specific expression, differential regulation and targeting of subunits of PKA (vol 69, pg 367, 1999)
    J. Steroid Biochem. Mol. Biol., 73 (1-2), 79-+
  4. Hansson V, Skålhegg BS, Taskén K (2000)
    Cyclic-AMP-dependent protein kinase (PKA) in testicular cells. Cell specific expression, differential regulation and targeting of subunits of PKA
    J Steroid Biochem Mol Biol, 73 (1-2), 81-92
    PubMed 10905822
  5. Herberg FW, Maleszka A, Eide T, Vossebein L, Tasken K (2000)
    Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding
    J Mol Biol, 298 (2), 329-39
    DOI 10.1006/jmbi.2000.3662, PubMed 10764601
  6. Orstavik S, Eide T, Collas P, Han IO, Taskén K, Kieff E, Jahnsen T, Skålhegg BS (2000)
    Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95
    Biol Cell, 92 (1), 27-37
    DOI 10.1016/S0248-4900(00)88761-4, PubMed 10761695
  7. Pursiheimo JP, Jalkanen M, Taskén K, Jaakkola P (2000)
    Involvement of protein kinase A in fibroblast growth factor-2-activated transcription
    Proc Natl Acad Sci U S A, 97 (1), 168-73
    DOI 10.1073/pnas.97.1.168, PubMed 10618389
  8. Reinton N, Collas P, Haugen TB, Skâlhegg BS, Hansson V, Jahnsen T, Taskén K (2000)
    Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis
    Dev Biol, 223 (1), 194-204
    DOI 10.1006/dbio.2000.9725, PubMed 10864471
  9. Reinton N, Orstavik S, Haugen TB, Jahnsen T, Taskén K, Skålhegg BS (2000)
    A novel isoform of human cyclic 3',5'-adenosine monophosphate-dependent protein kinase, c alpha-s, localizes to sperm midpiece
    Biol Reprod, 63 (2), 607-11
    DOI 10.1095/biolreprod63.2.607, PubMed 10906071
  10. Skalhegg BS, Tasken K (2000)
    Specificity in the cAMP/PKA signaling pathway. Differential expression,regulation, and subcellular localization of subunits of PKA
    Front Biosci, 5, D678-93
    DOI 10.2741/Skalhegg, PubMed 10922298
  11. Steen RL, Martins SB, Taskén K, Collas P (2000)
    Recruitment of protein phosphatase 1 to the nuclear envelope by A-kinase anchoring protein AKAP149 is a prerequisite for nuclear lamina assembly
    J Cell Biol, 150 (6), 1251-62
    DOI 10.1083/jcb.150.6.1251, PubMed 10995432
  12. Taskén K, Hansson V, Aukrust P, Frøland S, Skålhegg BS, Müller F, Tobin D, Vang T, Torgersen KM, Aandahl EM (2000)
    PKAI as a potential target for therapeutic intervention
    Drug News Perspect, 13 (1), 12-8
    PubMed 12937648

Publications 1999

  1. Aukrust P, Aandahl EM, Skålhegg BS, Nordøy I, Hansson V, Taskén K, Frøland SS, Müller F (1999)
    Increased activation of protein kinase A type I contributes to the T cell deficiency in common variable immunodeficiency
    J Immunol, 162 (2), 1178-85
    PubMed 9916750
  2. Collas P, Le Guellec K, Taskén K (1999)
    The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis
    J Cell Biol, 147 (6), 1167-80
    DOI 10.1083/jcb.147.6.1167, PubMed 10601332
  3. Gronning LM, Knutsen HK, Eskild W, Hansson V, Taskén K, Taskén KA (1999)
    Method of transfection affects the cAMP-mediated induction of the RIIbeta subunit of protein kinase A in Sertoli cells: inhibition of response by increase in intracellullar calcium
    Eur J Endocrinol, 141 (1), 75-82
    DOI 10.1530/eje.0.1410075, PubMed 10407227
  4. Grønning LM, Dahle MK, Taskén KA, Enerbäck S, Hedin L, Taskén K, Knutsen HK (1999)
    Isoform-specific regulation of the CCAAT/enhancer-binding protein family of transcription factors by 3',5'-cyclic adenosine monophosphate in Sertoli cells
    Endocrinology, 140 (2), 835-43
    DOI 10.1210/endo.140.2.6526, PubMed 9927313
  5. Hansson V, Skålhegg BS, Taskén K (1999)
    Cyclic-AMP-dependent protein kinase (PKA) in testicular cells. Cell specific expression, differential regulation and targeting of subunits of PKA
    J Steroid Biochem Mol Biol, 69 (1-6), 367-78
    DOI 10.1016/S0960-0760(99)00077-1, PubMed 10419014
  6. Keryer G, Skålhegg BS, Landmark BF, Hansson V, Jahnsen T, Taskén K (1999)
    Differential localization of protein kinase A type II isozymes in the Golgi-centrosomal area
    Exp Cell Res, 249 (1), 131-46
    DOI 10.1006/excr.1999.4447, PubMed 10328961
  7. Krall J, Taskén K, Staheli J, Jahnsen T, Movsesian MA (1999)
    Identification and quantitation of cAMP-dependent protein kinase R subunit isoforms in subcellular fractions of failing human myocardium
    J Mol Cell Cardiol, 31 (5), 971-80
    DOI 10.1006/jmcc.1999.0926, PubMed 10336837
  8. Laxminarayana D, Khan IU, Mishra N, Olorenshaw I, Taskén K, Kammer GM (1999)
    Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes
    J Immunol, 162 (9), 5639-48
    PubMed 10228048
  9. Maronde E, Wicht H, Taskén K, Genieser HG, Dehghani F, Olcese J, Korf HW (1999)
    CREB phosphorylation and melatonin biosynthesis in the rat pineal gland: involvement of cyclic AMP dependent protein kinase type II
    J Pineal Res, 27 (3), 170-82
    DOI 10.1111/j.1600-079X.1999.tb00613.x, PubMed 10535767
  10. Saxena M, Williams S, Taskén K, Mustelin T (1999)
    Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase
    Nat Cell Biol, 1 (5), 305-11
    DOI 10.1038/13024, PubMed 10559944
  11. Witczak O, Skålhegg BS, Keryer G, Bornens M, Taskén K, Jahnsen T, Orstavik S (1999)
    Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450
    EMBO J, 18 (7), 1858-68
    DOI 10.1093/emboj/18.7.1858, PubMed 10202149
  12. Aandahl EM, Aukrust P, Müller F, Hansson V, Taskén K, Frøland SS (1999)
    Additive effects of IL-2 and protein kinase A type I antagonist on function of T cells from HIV-infected patients on HAART
    AIDS, 13 (17), F109-14
    DOI 10.1097/00002030-199912030-00001, PubMed 10597771

Publications 1998

  1. Eide T, Coghlan V, Orstavik S, Holsve C, Solberg R, Skâlhegg BS, Lamb NJ, Langeberg L, Fernandez A, Scott JD, Jahnsen T, Taskén K (1998)
    Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95
    Exp Cell Res, 238 (2), 305-16
    DOI 10.1006/excr.1997.3855, PubMed 9473338
  2. Keryer G, Alsat E, Tasken K, Evain-Brion D (1998)
    Cyclic AMP-dependent protein kinases and human trophoblast cell differentiation in vitro
    J Cell Sci, 111 ( Pt 7), 995-1004
    PubMed 9490643
  3. Keryer G, Yassenko M, Labbé JC, Castro A, Lohmann SM, Evain-Brion D, Taskén K (1998)
    Mitosis-specific phosphorylation and subcellular redistribution of the RIIalpha regulatory subunit of cAMP-dependent protein kinase
    J Biol Chem, 273 (51), 34594-602
    DOI 10.1074/jbc.273.51.34594, PubMed 9852131
  4. Reinton N, Haugen TB, Orstavik S, Skålhegg BS, Hansson V, Jahnsen T, Taskén K (1998)
    The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon
    Genomics, 49 (2), 290-7
    DOI 10.1006/geno.1998.5240, PubMed 9598317
  5. Singh AE, Tasken K, Walker W, Frizzell RA, Watkins SC, Bridges RJ, Bradbury NA (1998)
    Characterization of PKA isoforms and kinase-dependent activation of chloride secretion in T84 cells
    Am. J. Physiol.-Cell Physiol., 275 (2), C562-C570
  6. Singh AK, Taskén K, Walker W, Frizzell RA, Watkins SC, Bridges RJ, Bradbury NA (1998)
    Characterization of PKA isoforms and kinase-dependent activation of chloride secretion in T84 cells
    Am J Physiol, 275 (2), C562-70
    DOI 10.1152/ajpcell.1998.275.2.C562, PubMed 9688611
  7. Skarpen E, Thoresen GH, Taskén K, Samuelsen JT, Jahnsen T, Schwarze PE, Huitfeldt HS (1998)
    Localization of cAMP-dependent signal transducers in early rat liver carcinogenesis
    Histochem Cell Biol, 109 (3), 203-9
    DOI 10.1007/s004180050219, PubMed 9541468
  8. Skålhegg BS, Johansen AK, Levy FO, Andersson KB, Aandahl EM, Blomhoff HK, Hansson V, Taskén K (1998)
    Isozymes of cyclic AMP-dependent protein kinases (PKA) in human lymphoid cell lines: levels of endogenous cAMP influence levels of PKA subunits and growth in lymphoid cell lines
    J Cell Physiol, 177 (1), 85-93
    DOI 10.1002/(SICI)1097-4652(199810)177:1<85::AID-JCP9>3.0.CO;2-A, PubMed 9731748
  9. Strömstedt M, Waterman MR, Haugen TB, Taskén K, Parvinen M, Rozman D (1998)
    Elevated expression of lanosterol 14alpha-demethylase (CYP51) and the synthesis of oocyte meiosis-activating sterols in postmeiotic germ cells of male rats
    Endocrinology, 139 (5), 2314-21
    DOI 10.1210/endo.139.5.5984, PubMed 9564839
  10. Taskén K, Naylor SL, Solberg R, Jahnsen T (1998)
    Mapping of the gene encoding the regulatory subunit RII alpha of cAMP-dependent protein kinase (locus PRKAR2A) to human chromosome region 3p21.3-p21.2
    Genomics, 50 (3), 378-81
    DOI 10.1006/geno.1998.5326, PubMed 9676433
  11. Taskén K, Schulz T, Elgjo K, Skullerud K, Relman D, Brubakk O (1998)
    Diagnostic utility of the polymerase chain reaction in 2 cases of suspected Whipple disease
    Arch Intern Med, 158 (7), 801-3
    DOI 10.1001/archinte.158.7.801, PubMed 9554687
  12. Vang T, Taskén K, Skålhegg BS, Hansson V, Levy FO (1998)
    Kinetic properties of the C-terminal Src kinase, p50csk
    Biochim Biophys Acta, 1384 (2), 285-93
    DOI 10.1016/s0167-4838(97)00202-1, PubMed 9659389
  13. Weber JR, Orstavik S, Torgersen KM, Danbolt NC, Berg SF, Ryan JC, Taskén K, Imboden JB, Vaage JT (1998)
    Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells
    J Exp Med, 187 (7), 1157-61
    DOI 10.1084/jem.187.7.1157, PubMed 9529333
  14. Aandahl EM, Aukrust P, Skålhegg BS, Müller F, Frøland SS, Hansson V, Taskén K (1998)
    Protein kinase A type I antagonist restores immune responses of T cells from HIV-infected patients
    FASEB J, 12 (10), 855-62
    DOI 10.1096/fasebj.12.10.855, PubMed 9657525

Publications 1997

  1. Foss KB, Solberg R, Simard J, Myklebust F, Hansson V, Jahnsen T, Taskén K (1997)
    Molecular cloning, upstream sequence and promoter studies of the human gene for the regulatory subunit RII alpha of cAMP-dependent protein kinase
    Biochim Biophys Acta, 1350 (1), 98-108
    DOI 10.1016/s0167-4781(96)00152-2, PubMed 9003463
  2. Knutsen HK, Taskén K, Eskild W, Richards JS, Kurten RC, Torjesen PA, Jahnsen T, Hansson V, Guérin S, Taskén KA (1997)
    Characterization of the 5'-flanking region of the gene for the cAMP-inducible protein kinase A subunit, RIIbeta, in Sertoli cells
    Mol Cell Endocrinol, 129 (1), 101-14
    DOI 10.1016/s0303-7207(97)04045-8, PubMed 9175634
  3. Maronde E, Middendorff R, Telgmann R, Müller D, Hemmings B, Taskén K, Olcese J (1997)
    Melatonin synthesis in the bovine pineal gland is regulated by type II cyclic AMP-dependent protein kinase
    J Neurochem, 68 (2), 770-7
    DOI 10.1046/j.1471-4159.1997.68020770.x, PubMed 9003068
  4. Orstavik S, Natarajan V, Taskén K, Jahnsen T, Sandberg M (1997)
    Characterization of the human gene encoding the type I alpha and type I beta cGMP-dependent protein kinase (PRKG1)
    Genomics, 42 (2), 311-8
    DOI 10.1006/geno.1997.4743, PubMed 9192852
  5. Skålhegg BS, Taskén K (1997)
    Specificity in the cAMP/PKA signaling pathway. differential expression, regulation, and subcellular localization of subunits of PKA
    Front Biosci, 2, d331-42
    PubMed 9236186
  6. Solberg R, Sandberg M, Natarajan V, Torjesen PA, Hansson V, Jahnsen T, Taskén K (1997)
    The human gene for the regulatory subunit RI alpha of cyclic adenosine 3', 5'-monophosphate-dependent protein kinase: two distinct promoters provide differential regulation of alternately spliced messenger ribonucleic acids
    Endocrinology, 138 (1), 169-81
    DOI 10.1210/endo.138.1.4864, PubMed 8977401
  7. Taskén K, Skålhegg BS, Taskén KA, Solberg R, Knutsen HK, Levy FO, Sandberg M, Orstavik S, Larsen T, Johansen AK, Vang T, Schrader HP, Reinton NT, Torgersen KM, Hansson V, Jahnsen T (1997)
    Structure, function, and regulation of human cAMP-dependent protein kinases
    Adv Second Messenger Phosphoprotein Res, 31, 191-204
    PubMed 9344252
  8. Telgmann R, Maronde E, Taskén K, Gellersen B (1997)
    Activated protein kinase A is required for differentiation-dependent transcription of the decidual prolactin gene in human endometrial stromal cells
    Endocrinology, 138 (3), 929-37
    DOI 10.1210/endo.138.3.5004, PubMed 9048592
  9. Torgersen KM, Vaage JT, Levy FO, Hansson V, Rolstad B, Taskén K (1997)
    Selective activation of cAMP-dependent protein kinase type I inhibits rat natural killer cell cytotoxicity
    J Biol Chem, 272 (9), 5495-500
    DOI 10.1074/jbc.272.9.5495, PubMed 9038153

Publications 1996

  1. Hansson V, Skålhegg BS, Taskén K (1996)
    Is basic endocrinology disappearing?
    Eur J Endocrinol, 134 (1), 7-8
    DOI 10.1530/eje.0.1340007, PubMed 8590959
  2. Levy FO, Rasmussen AM, Taskén K, Skålhegg BS, Huitfeldt HS, Funderud S, Smeland EB, Hansson V (1996)
    Cyclic AMP-dependent protein kinase (cAK) in human B cells: co-localization of type I cAK (RI alpha 2 C2) with the antigen receptor during anti-immunoglobulin-induced B cell activation
    Eur J Immunol, 26 (6), 1290-6
    DOI 10.1002/eji.1830260617, PubMed 8647207
  3. Levy FO, Taskén K, Hansson V (1996)
    Report on the 9th European Workshop on the Molecular and Cellular Endocrinology of the Testis
    Mol Cell Endocrinol, 122 (1), 1-13
    DOI 10.1016/0303-7207(96)03883-x, PubMed 8898343
  4. Orstavik S, Solberg R, Taskén K, Nordahl M, Altherr MR, Hansson V, Jahnsen T, Sandberg M (1996)
    Molecular cloning, cDNA structure, and chromosomal localization of the human type II cGMP-dependent protein kinase
    Biochem Biophys Res Commun, 220 (3), 759-65
    DOI 10.1006/bbrc.1996.0477, PubMed 8607838
  5. Taskén K, Solberg R, Zhao Y, Hansson V, Jahnsen T, Siciliano MJ (1996)
    The gene encoding the catalytic subunit C alpha of cAMP-dependent protein kinase (locus PRKACA) localizes to human chromosome region 19p13.1
    Genomics, 36 (3), 535-8
    DOI 10.1006/geno.1996.0501, PubMed 8884279

Publications 1994

  1. Andersson KB, Taskén K, Blomhoff HK (1994)
    Cyclic AMP downregulates c-myc expression by inhibition of transcript initiation in human B-precursor Reh cells
    FEBS Lett, 337 (1), 71-6
    DOI 10.1016/0014-5793(94)80632-2, PubMed 8276117
  2. Berg JP, Ree AH, Sandvik JA, Taskén K, Landmark BF, Torjesen PA, Haug E (1994)
    1,25-dihydroxyvitamin D3 alters the effect of cAMP in thyroid cells by increasing the regulatory subunit type II beta of the cAMP-dependent protein kinase
    J Biol Chem, 269 (51), 32233-8
    PubMed 7798223
  3. Christoffersen J, Smeland EB, Stokke T, Taskén K, Andersson KB, Blomhoff HK (1994)
    Retinoblastoma protein is rapidly dephosphorylated by elevated cyclic adenosine monophosphate levels in human B-lymphoid cells
    Cancer Res, 54 (8), 2245-50
    PubMed 8174134
  4. Foss KB, Landmark B, Skålhegg BS, Taskén K, Jellum E, Hansson V, Jahnsen T (1994)
    Characterization of in-vitro-translated human regulatory and catalytic subunits of cAMP-dependent protein kinases
    Eur J Biochem, 220 (1), 217-23
    DOI 10.1111/j.1432-1033.1994.tb18617.x, PubMed 8119290
  5. Kristoffersen AK, Taskèn K, Rollag H (1994)
    Expression of protein kinase A and protein kinase C during ongoing human cytomegalovirus infection
    Arch Virol, 138 (1-2), 85-93
    DOI 10.1007/bf01310040, PubMed 7980013
  6. Levy FO, Holtgreve-Grez H, Taskén K, Solberg R, Ried T, Gudermann T (1994)
    Assignment of the gene encoding the 5-HT1E serotonin receptor (S31) (locus HTR1E) to human chromosome 6q14-q15
    Genomics, 22 (3), 637-40
    DOI 10.1006/geno.1994.1439, PubMed 8001977
  7. Ree AH, Taskén K, Hansson V (1994)
    Regulation of glucocorticoid receptor (GR) mRNA and protein levels by phorbol ester in MCF-7 cells. Mechanism of GR mRNA induction and decay
    J Steroid Biochem Mol Biol, 48 (1), 23-9
    DOI 10.1016/0960-0760(94)90247-X, PubMed 8136303
  8. Skålhegg BS, Rasmussen AM, Taskén K, Hansson V, Jahnsen T, Lea T (1994)
    Cyclic AMP sensitive signalling by the CD28 marker requires concomitant stimulation by the T-cell antigen receptor (TCR/CD3) complex
    Scand J Immunol, 40 (2), 201-8
    DOI 10.1111/j.1365-3083.1994.tb03451.x, PubMed 8047842
  9. Skålhegg BS, Taskén K, Hansson V, Huitfeldt HS, Jahnsen T, Lea T (1994)
    Location of cAMP-dependent protein kinase type I with the TCR-CD3 complex
    Science, 263 (5143), 84-7
    DOI 10.1126/science.8272870, PubMed 8272870
  10. Solberg R, Taskén K, Wen W, Coghlan VM, Meinkoth JL, Scott JD, Jahnsen T, Taylor SS (1994)
    Human regulatory subunit RI beta of cAMP-dependent protein kinases: expression, holoenzyme formation and microinjection into living cells
    Exp Cell Res, 214 (2), 595-605
    DOI 10.1006/excr.1994.1297, PubMed 7925653
  11. Taskén K, Andersson KB, Erikstein BK, Hansson V, Jahnsen T, Blomhoff HK (1994)
    Regulation of growth in a neoplastic B cell line by transfected subunits of 3',5'-cyclic adenosine monophosphate-dependent protein kinase
    Endocrinology, 135 (5), 2109-19
    DOI 10.1210/endo.135.5.7956934, PubMed 7956934

Publications 1993

  1. JAHNSEN T, TASKEN K, LANDMARK B, KNUTSEN H, TASKEN KA, SOLBERG R, FOSS KB, SKALHEGG B, ORSTAVIK S, ESKILD W, HANSSON V (1993)
    MULTIPLE GENES FOR REGULATORY AND CATALYTIC SUBUNITS OF CYCLIC-AMP-DEPENDENT PROTEIN-KINASES ARE DIFFERENTIALLY EXPRESSED AND REGULATED IN TESTICULAR CELLS
    I C S S, 3, 29-33
  2. Krajci P, Taskén K, Kvale D, Brandtzaeg P (1993)
    Interferon-gamma stimulation of messenger RNA for human secretory component (poly-Ig receptor) depends on continuous intermediate protein synthesis
    Scand J Immunol, 37 (2), 251-6
    DOI 10.1111/j.1365-3083.1993.tb01763.x, PubMed 8434236
  3. Taskén K, Andersson KB, Skålhegg BS, Taskén KA, Hansson V, Jahnsen T, Blomhoff HK (1993)
    Reciprocal regulation of mRNA and protein for subunits of cAMP-dependent protein kinase (RI alpha and C alpha) by cAMP in a neoplastic B cell line (Reh)
    J Biol Chem, 268 (31), 23483-9
    PubMed 8226875
  4. Taskén K, Skålhegg BS, Solberg R, Andersson KB, Taylor SS, Lea T, Blomhoff HK, Jahnsen T, Hansson V (1993)
    Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes
    J Biol Chem, 268 (28), 21276-83
    PubMed 8407966

Publications 1992

  1. Krajci P, Kvale D, Taskén K, Brandtzaeg P (1992)
    Molecular cloning and exon-intron mapping of the gene encoding human transmembrane secretory component (the poly-Ig receptor)
    Eur J Immunol, 22 (9), 2309-15
    DOI 10.1002/eji.1830220920, PubMed 1355431
  2. Taskén KA, Knutsen HK, Eikvar L, Taskén K, Eskild W, Jahnsen T, Hansson V (1992)
    Protein kinase C activation by 12-O-tetradecanoylphorbol 13-acetate modulates messenger ribonucleic acid levels for two of the regulatory subunits of 3',5'-cyclic adenosine monophosphate-dependent protein kinases (RII beta and RI alpha) via multiple and distinct mechanisms
    Endocrinology, 130 (3), 1271-80
    DOI 10.1210/endo.130.3.1311233, PubMed 1311233

Publications 1991

  1. Solberg R, Taskén K, Keiserud A, Jahnsen T (1991)
    Molecular cloning, cDNA structure and tissue-specific expression of the human regulatory subunit RI beta of cAMP-dependent protein kinases
    Biochem Biophys Res Commun, 176 (1), 166-72
    DOI 10.1016/0006-291x(91)90904-l, PubMed 1708242
  2. Taskén KA, Knutsen HK, Attramadal H, Taskén K, Jahnsen T, Hansson V, Eskild W (1991)
    Different mechanisms are involved in cAMP-mediated induction of mRNAs for subunits of cAMP-dependent protein kinases
    Mol Endocrinol, 5 (1), 21-8
    DOI 10.1210/mend-5-1-21, PubMed 1850108

Publications 1990

  1. Dissen E, Vaage JT, Taskén K, Jahnsen T, Rolstad B, Fossum S (1990)
    Alloreactive lymphokine-activated killer cells from athymic nude rats do not express CD3-associated alpha/beta or gamma/delta T cell receptors
    Int Immunol, 2 (5), 453-60
    DOI 10.1093/intimm/2.5.453, PubMed 2150758
  2. Taskén K, Kvale D, Hansson V, Jahnsen T (1990)
    Protein kinase C activation selectively increases mRNA levels for one of the regulatory subunits (RI alpha) of cAMP-dependent protein kinases in HT-29 cells
    Biochem Biophys Res Commun, 172 (2), 409-14
    DOI 10.1016/0006-291x(90)90688-j, PubMed 2241943

Publications 1988

  1. Levy FO, Oyen O, Sandberg M, Taskén K, Eskild W, Hansson V, Jahnsen T (1988)
    Molecular cloning, complementary deoxyribonucleic acid structure and predicted full-length amino acid sequence of the hormone-inducible regulatory subunit of 3'-5'-cyclic adenosine monophosphate-dependent protein kinase from human testis
    Mol Endocrinol, 2 (12), 1364-73
    DOI 10.1210/mend-2-12-1364, PubMed 2851102
  2. Oyen O, Sandberg M, Levy FO, Taskén K, Beebe S, Hansson V, Jahnsen T (1988)
    Molecular cloning and cell-specific expression of newly discovered subunits of cAMP-dependent protein kinases. Implications for different cellular responses to cAMP
    APMIS Suppl, 2, 238-50
    PubMed 2846017
  3. OYEN O, SANDBERG M, LEVY FO, TASKEN K, BEEBE S, HANSSON V, JAHNSEN T (1988)
    MOLECULAR-CLONING AND CELL-SPECIFIC EXPRESSION OF NEWLY DISCOVERED SUBUNITS OF CAMP-DEPENDENT PROTEIN-KINASES - IMPLICATIONS FOR DIFFERENT CELLULAR-RESPONSES TO CAMP
    APMIS, 96 2, 238-250

Publications 1987

  1. Sandberg M, Taskén K, Oyen O, Hansson V, Jahnsen T (1987)
    Molecular cloning, cDNA structure and deduced amino acid sequence for a type I regulatory subunit of cAMP-dependent protein kinase from human testis
    Biochem Biophys Res Commun, 149 (3), 939-45
    DOI 10.1016/0006-291x(87)90499-2, PubMed 3426618

 
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