Publications from OUS - Cell Signaling and Immune Regulation (Kjetil Taskén)
64 publications found
Publications 2024
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Patient-derived acellular ascites fluid affects drug responses in ovarian cancer cell lines through the activation of key signalling pathways
Mol Oncol (in press)
DOI 10.1002/1878-0261.13726, PubMed 39245677 -
Acta Oncologica Nordic Precision Cancer Medicine Symposium 2023 - merging clinical research and standard healthcare
Acta Oncol, 63, 487-490
DOI 10.2340/1651-226X.2024.24954, PubMed 38910311 -
T cells with increased responsiveness cause obesity in mice without diet intervention
iScience, 27 (4), 109471
DOI 10.1016/j.isci.2024.109471, PubMed 38551005 -
[Raising the quality of cancer treatment]
Tidsskr Nor Laegeforen, 144 (1)
DOI 10.4045/tidsskr.23.0740, PubMed 38258713 -
Immunophenotyping with (phospho)protein profiling and fluorescent cell barcoding for single-cell signaling analysis and biomarker discovery
NPJ Precis Oncol, 8 (1), 107
DOI 10.1038/s41698-024-00604-y, PubMed 38769096 -
Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127
Science, 383 (6682), eadi5798
DOI 10.1126/science.adi5798, PubMed 38301010 -
IMPRESS-Norway: improving public cancer care by implementing precision medicine in Norway; inclusion rates and preliminary results
Acta Oncol, 63, 379-384
DOI 10.2340/1651-226X.2024.28322, PubMed 38779911 -
PI3K Inhibitors in Hematology: When One Door Closes…
Clin Cancer Res, 30 (17), 3667-3675
DOI 10.1158/1078-0432.CCR-24-0967, PubMed 38967552 -
Evolutionary mode and timing of dissemination of high-grade serous carcinomas
JCI Insight, 9 (3)
DOI 10.1172/jci.insight.170423, PubMed 38175731 -
PCM4EU and PRIME-ROSE: Collaboration for implementation of precision cancer medicine in Europe
Acta Oncol, 63, 385-391
DOI 10.2340/1651-226X.2024.34791, PubMed 38779910
Publications 2023
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Clinical forecasting of acute myeloid leukemia using ex vivo drug-sensitivity profiling
Cell Rep Methods, 3 (12), 100654
DOI 10.1016/j.crmeth.2023.100654, PubMed 38065095 -
Standardized assays to monitor drug sensitivity in hematologic cancers
Cell Death Discov, 9 (1), 435
DOI 10.1038/s41420-023-01722-5, PubMed 38040674 -
Small molecule inhibitors targeting regulatory T cells for cancer treatment
Eur J Immunol, 54 (2), e2350448
DOI 10.1002/eji.202350448, PubMed 37937687 -
A tumor microenvironment model of chronic lymphocytic leukemia enables drug sensitivity testing to guide precision medicine
Cell Death Discov, 9 (1), 125
DOI 10.1038/s41420-023-01426-w, PubMed 37055391 -
Phenotypic deconvolution in heterogeneous cancer cell populations using drug-screening data
Cell Rep Methods, 3 (3), 100417
DOI 10.1016/j.crmeth.2023.100417, PubMed 37056380 -
Modified study designs to expand treatment options in personalised oncology: a multistakeholder view
Eur J Cancer, 194, 113278
DOI 10.1016/j.ejca.2023.113278, PubMed 37820553 -
Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure
Circulation, 147 (16), 1221-1236
DOI 10.1161/CIRCULATIONAHA.121.054168, PubMed 36876489 -
PI3K inhibitors in chronic lymphocytic leukemia: where do we go from here?
Haematologica, 108 (1), 9-21
DOI 10.3324/haematol.2022.281266, PubMed 35899388 -
Diversity of intratumoral regulatory T cells in B-cell non-Hodgkin lymphoma
Blood Adv, 7 (23), 7216-7230
DOI 10.1182/bloodadvances.2023010158, PubMed 37695745 -
NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts
Blood, 141 (13), 1584-1596
DOI 10.1182/blood.2022016934, PubMed 36375120
Publications 2022
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Approach to a patient with "double refractory" chronic lymphocytic leukemia: "Double, double toil and trouble" (Shakespeare)
Am J Hematol, 97 Suppl 2, S19-S25
DOI 10.1002/ajh.26682, PubMed 36125036 -
Computational Pipeline for Rational Drug Combination Screening in Patient-Derived Cells
Methods Mol Biol, 2449, 327-348
DOI 10.1007/978-1-0716-2095-3_14, PubMed 35507270 -
Functional precision cancer medicine: drug sensitivity screening enabled by cell culture models
Trends Pharmacol Sci, 43 (11), 973-985
DOI 10.1016/j.tips.2022.08.009, PubMed 36163057 -
Mutational analysis and protein profiling predict drug sensitivity in multiple myeloma cell lines
Front Oncol, 12, 1040730
DOI 10.3389/fonc.2022.1040730, PubMed 36523963 -
Ex vivo drug sensitivity screening in multiple myeloma identifies drug combinations that act synergistically
Mol Oncol, 16 (6), 1241-1258
DOI 10.1002/1878-0261.13191, PubMed 35148457 -
Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
J Transl Med, 20 (1), 225
DOI 10.1186/s12967-022-03432-5, PubMed 35568909 -
Correction to: Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
J Transl Med, 20 (1), 317
DOI 10.1186/s12967-022-03518-0, PubMed 35841045 -
T-helper cell regulation of CD45 phosphatase activity by galectin-1 and CD43 governs chronic lymphocytic leukaemia proliferation
Br J Haematol, 198 (3), 556-573
DOI 10.1111/bjh.18285, PubMed 35655388 -
Functional testing of relapsed chronic lymphocytic leukemia guides precision medicine and maps response and resistance mechanisms. An index case
Haematologica, 107 (8), 1994-1998
DOI 10.3324/haematol.2021.280393, PubMed 35236056 -
Determining drug dose in the era of targeted therapies: playing it (un)safe?
Blood Cancer J, 12 (8), 123
DOI 10.1038/s41408-022-00720-7, PubMed 35999205 -
A national precision cancer medicine implementation initiative for Norway
Nat Med, 28 (5), 885-887
DOI 10.1038/s41591-022-01777-4, PubMed 35513529 -
Immunoregulatory signal networks and tumor immune evasion mechanisms: insights into therapeutic targets and agents in clinical development
Biochem J, 479 (20), 2219-2260
DOI 10.1042/BCJ20210233, PubMed 36305711 -
Functional Testing to Characterize and Stratify PI3K Inhibitor Responses in Chronic Lymphocytic Leukemia
Clin Cancer Res, 28 (20), 4444-4455
DOI 10.1158/1078-0432.CCR-22-1221, PubMed 35998013
Publications 2021
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The Presence of Activated T Cell Subsets prior to Transplantation Is Associated with Increased Rejection Risk in Pancreas Transplant Recipients
J Immunol, 207 (10), 2501-2511
DOI 10.4049/jimmunol.2001103, PubMed 34607938 -
A Phase I/II randomized trial of H56:IC31 vaccination and adjunctive cyclooxygenase-2-inhibitor treatment in tuberculosis patients
Nat Commun, 12 (1), 6774
DOI 10.1038/s41467-021-27029-6, PubMed 34811370 -
A heterozygous germline CD100 mutation in a family with primary sclerosing cholangitis
Sci Transl Med, 13 (582)
DOI 10.1126/scitranslmed.abb0036, PubMed 33627483 -
Plasma LOX-Products and Monocyte Signaling Is Reduced by Adjunctive Cyclooxygenase-2 Inhibitor in a Phase I Clinical Trial of Tuberculosis Patients
Front Cell Infect Microbiol, 11, 669623
DOI 10.3389/fcimb.2021.669623, PubMed 34307194 -
Systems approach reveals distinct and shared signaling networks of the four PGE2 receptors in T cells
Sci Signal, 14 (703), eabc8579
DOI 10.1126/scisignal.abc8579, PubMed 34609894 -
Phosphoproteomics-Based Characterization of Prostaglandin E2 Signaling in T Cells
Mol Pharmacol, 99 (5), 370-382
DOI 10.1124/molpharm.120.000170, PubMed 33674363 -
Enhanced Gut-Homing Dynamics and Pronounced Exhaustion of Mucosal and Blood CD4+ T Cells in HIV-Infected Immunological Non-Responders
Front Immunol, 12, 744155
DOI 10.3389/fimmu.2021.744155, PubMed 34691047 -
Mcl-1 and Bcl-xL levels predict responsiveness to dual MEK/Bcl-2 inhibition in B-cell malignancies
Mol Oncol, 16 (5), 1153-1170
DOI 10.1002/1878-0261.13153, PubMed 34861096 -
COVID-19 in patients with CLL: improved survival outcomes and update on management strategies
Blood, 138 (18), 1768-1773
DOI 10.1182/blood.2021011841, PubMed 34297826 -
Overcoming resistance to targeted therapies in chronic lymphocytic leukemia
Blood Adv, 5 (1), 334-343
DOI 10.1182/bloodadvances.2020003423, PubMed 33570649 -
Aspirin as secondary prevention in colorectal cancer liver metastasis (ASAC trial): study protocol for a multicentre randomized placebo-controlled trial
Trials, 22 (1), 642
DOI 10.1186/s13063-021-05587-w, PubMed 34544470
Publications 2020
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Optic Atrophy 1 Controls Human Neuronal Development by Preventing Aberrant Nuclear DNA Methylation
iScience, 23 (6), 101154
DOI 10.1016/j.isci.2020.101154, PubMed 32450518 -
Outcomes of COVID-19 in patients with CLL: a multicenter international experience
Blood, 136 (10), 1134-1143
DOI 10.1182/blood.2020006965, PubMed 32688395 -
Sensing of HIV-1 by TLR8 activates human T cells and reverses latency
Nat Commun, 11 (1), 147
DOI 10.1038/s41467-019-13837-4, PubMed 31919342 -
B cell signalling pathways-New targets for precision medicine in chronic lymphocytic leukaemia
Scand J Immunol, 92 (5), e12931
DOI 10.1111/sji.12931, PubMed 32640099
Publications 2019
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EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology
SLAS Discov, 24 (3), 398-413
DOI 10.1177/2472555218816276, PubMed 30616481 -
The PI3K p110δ Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function
J Immunol, 202 (5), 1397-1405
DOI 10.4049/jimmunol.1701703, PubMed 30692213 -
Hierarchical Normalized Completely Random Measures for Robust Graphical Modeling
Bayesian Anal, 14 (4), 1271-1301
DOI 10.1214/19-ba1153, PubMed 32431780 -
Correction: Ezrin-anchored PKA phosphorylates serine 369 and 373 on connexin 43 to enhance gap junction assembly, communication, and cell fusion
Biochem J, 476 (13), 1927
DOI 10.1042/BCJ-2017-0529_COR, PubMed 31266855 -
Remodeling of secretory lysosomes during education tunes functional potential in NK cells
Nat Commun, 10 (1), 514
DOI 10.1038/s41467-019-08384-x, PubMed 30705279 -
Off-label uses of drugs for depression
Eur J Pharmacol, 865, 172732
DOI 10.1016/j.ejphar.2019.172732, PubMed 31622593 -
An in vitro assay for biomarker discovery and dose prediction applied to ibrutinib plus venetoclax treatment of CLL
Leukemia, 34 (2), 478-487
DOI 10.1038/s41375-019-0569-7, PubMed 31471562 -
Carboxyl-Terminal Src Kinase Binds CD28 upon Activation and Mutes Downstream Signaling
J Immunol, 203 (4), 1055-1063
DOI 10.4049/jimmunol.1801660, PubMed 31292214 -
FOXK1 and FOXK2 regulate aerobic glycolysis
Nature, 566 (7743), 279-283
DOI 10.1038/s41586-019-0900-5, PubMed 30700909
Publications 2018
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Cryopreservation of primary B cells minimally influences their signaling responses
Sci Rep, 8 (1), 17651
DOI 10.1038/s41598-018-36121-9, PubMed 30518828 -
OPA1-anchored PKA phosphorylates perilipin 1 on S522 and S497 in adipocytes differentiated from human adipose stem cells
Mol Biol Cell, 29 (12), 1487-1501
DOI 10.1091/mbc.E17-09-0538, PubMed 29688805 -
Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects
J Allergy Clin Immunol, 142 (6), 1932-1946
DOI 10.1016/j.jaci.2018.02.055, PubMed 29729943
Publications 2016
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Erratum: Individualized strategies to target specific mechanisms of disease in malignant melanoma patients displaying unique mutational signatures
Oncotarget, 7 (5), 6352
DOI 10.18632/oncotarget.7118, PubMed 26997263
Publications 2010
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Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis
Proc Natl Acad Sci U S A, 107 (27), 12233-8
DOI 10.1073/pnas.0915112107, PubMed 20566843
Publications 2009
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Profiling of mismatch discrimination in RNAi enabled rational design of allele-specific siRNAs
Nucleic Acids Res, 37 (22), 7560-9
DOI 10.1093/nar/gkp835, PubMed 19815667 -
Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion
Nat Med, 15 (6), 633-40
DOI 10.1038/nm.1968, PubMed 19465928