Sigrid S. Skånland

  • Lab leader and Researcher; PhD
  • +47 2278 1981

Related imageRoom: K06.116

  Norway

ORCID: Sigrid Skånland

Twitter: @SigridSkanland


Address
Oslo University Hospital
The Norwegian Radium Hospital
Institute for Cancer Research
Department of Cancer Immunology
Ullernchausseen 70
0379 Oslo, Norway

Biography
Sigrid S. Skånland received her PhD from the Faculty of Mathematics and Natural Sciences at University of Oslo in 2009, under the supervision of Prof. Kirsten Sandvig. She was then awarded with a long-term EMBO fellowship to do her post-doctoral training in the Molecular Signaling Group of Prof. Ivan Dikic (2009-2011) at the University Hospital Frankfurt, Germany. From 2011, Dr. Skånland has been affiliated with the research group of Prof. Kjetil Taskén, first at the Nordic EMBL Partnership for Molecular Medicine in Norway (NCMM), currently at Oslo University Hospital. Here, she has established her own research group focusing on functional precision medicine in B-cell malignancies, in particular chronic lymphocytic leukemia (CLL).


Cancer cell signaling. In our reserach, we analyse cell signaling in a high-throughput manner by use of phospho flow cytometry with fluorescent cell barcoding. We study how cell signaling is altered in cancer cells, and how cancer therapies affect cell signaling. Our aims are to identify potential drug targets and biomarkers for precision medicine. See video of the method below (Skånland, J Vis Exp, 2018).


Curriculum Vitae
Education
2009                  PhD “Mechanisms in intracellular transport of toxins.”
                           The Norwegian Radium Hospital, University of Oslo, NO
                           Supervisor: Prof. Kirsten Sandvig
2005                  MSc “The phosphatidylinositol 3-kinase hVps34 modulates endosome to Golgi transport of ricin.”
                           The Norwegian Radium Hospital, University of Oslo, NO

Current positions
2018-present    Researcher and Lab leader in Prof. Kjetil Taskén’s lab
                            Oslo University Hospital, Institute for Cancer Research, Oslo, NO

Previous positions
2017-2018        Lab leader in Prof. Kjetil Taskén’s lab
                           Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, NO
2015-2018        Senior Researcher in Prof. Kjetil Taskén’s lab
                           NCMM, Nordic EMBL Partnership, University of Oslo, NO
2011-2015        Postdoc in Prof. Kjetil Taskén’s lab
                           NCMM, Nordic EMBL Partnership, University of Oslo, NO
2009-2011        EMBO fellow/Postdoc in Prof. Ivan Dikic’s lab
                           Institute of Biochemistry II, Goethe University School of Medicine, DE

Fellowships and Awards
2019                   Legacy: Lilly Constance og Karl Ingolf Larssons stiftelse
2015-2019         Career Development Research Fellowship, The Norwegian Cancer Society
2012                   Legacy: Ella og Kristian Nyerrøds stiftelse for medisinsk forskning ved Universitetet i Oslo
2009-2011         EMBO Long-term fellowship

Mobility
2019                  Visiting scientist (1 month) in Dr. Adrian Wiestner's lab
                           NIH, Bethesda, MD, USA
2009-2011        EMBO fellow/Postdoc in Prof. Ivan Dikic’s lab
                           Institute of Biochemistry II, Goethe University School of Medicine, DE
2006                  Visiting student (3 months) in Prof. Tom A. Rapoport’s lab
                           Harvard Medical School, Boston, MA, USA

Supervision and teaching
2015-present    1 Postdoc, 1 PhD, 1 MD/PhD, 4 Master students, 1 UiO:Life Science internship
2020-present    MF9135 - Biomarkers in clinical research (PhD course), University of Oslo, NO
2019-present    MF9120BTS - Molecular Medicine (national PhD course), University of Oslo, NO
2009-2011         Laboratory practical courses. Goethe University School of Medicine, DE


 

 

Publications 2020

Mato AR, Roeker LE, Lamanna N, Allan JN, Leslie L, Pagel JM, Patel K, Osterborg A, Wojenski D, Kamdar M, Huntington SF, Davids MS, Brown JR, Antic D, Jacobs R, Ahn IE, Pu J, Isaac KM, Barr PM, Ujjani CS, Geyer MB, Berman E, Zelenetz AD, Malakhov N, Furman RR et al. (2020)
Outcomes of COVID-19 in patients with CLL: a multicenter international experience
Blood, 136 (10), 1134-1143
DOI 10.1182/blood.2020006965, PubMed 32688395

Skånland SS, Karlsen L, Taskén K (2020)
B cell signaling pathways - new targets for precision medicine in CLL
Scand J Immunol, e12931 (in press)
DOI 10.1111/sji.12931, PubMed 32640099

Publications 2019

Skånland SS, Cieślar-Pobuda A (2019)
Off-label uses of drugs for depression
Eur J Pharmacol, 865, 172732
DOI 10.1016/j.ejphar.2019.172732, PubMed 31622593

Skånland SS, Cremaschi A, Bendiksen H, Hermansen JU, Thimiri Govinda Raj DB, Munthe LA, Tjønnfjord GE, Taskén K (2019)
An in vitro assay for biomarker discovery and dose prediction applied to ibrutinib plus venetoclax treatment of CLL
Leukemia, 34 (2), 478-487
DOI 10.1038/s41375-019-0569-7, PubMed 31471562

Skånland SS, Taskén K (2019)
Carboxyl-Terminal Src Kinase Binds CD28 upon Activation and Mutes Downstream Signaling
J Immunol, 203 (4), 1055-1063
DOI 10.4049/jimmunol.1801660, PubMed 31292214

Publications 2018

Hermansen JU, Tjønnfjord GE, Munthe LA, Taskén K, Skånland SS (2018)
Cryopreservation of primary B cells minimally influences their signaling responses
Sci Rep, 8 (1), 17651
DOI 10.1038/s41598-018-36121-9, PubMed 30518828

Myhrvold IK, Cremaschi A, Hermansen JU, Tjønnfjord GE, Munthe LA, Taskén K, Skånland SS (2018)
Single cell profiling of phospho-protein levels in chronic lymphocytic leukemia
Oncotarget, 9 (10), 9273-9284
DOI 10.18632/oncotarget.23949, PubMed 29507689

Skånland SS (2018)
Phospho Flow Cytometry with Fluorescent Cell Barcoding for Single Cell Signaling Analysis and Biomarker Discovery
J Vis Exp (140)
DOI 10.3791/58386, PubMed 30346411

Thimiri Govinda Raj DB, Cremaschi A, Skånland SS, Gade A, Schjesvold FH, Tjønnfjord GE, Munthe LA, Tasken K (2018)
In-Vitro Drug Sensitivity Screening in Chronic Lymphocytic Leukemia (CLL) Primary Patient Samples Identifies Drug Candidates for Precision Cancer Therapy
Blood, 132, 4676
DOI 10.1182/blood-2018-99-110357, PublikaID 304

Thimiri Govinda Raj DB, Giliberto M, Cremaschi A, Skånland SS, Gade A, Tjønnfjord GE, Schjesvold FH, Munthe LA, Tasken K (2018)
Drug Sensitivity Screening on Multiple Myeloma for Precision Cancer Therapy
Blood, 132, 4677
DOI 10.1182/blood-2018-99-110669, PublikaID 303

Publications 2015

Parente-Ribes A, Skånland SS, Bürgler S, Os A, Wang D, Bogen B, Tjønnfjord GE, Taskén K, Munthe LA (2015)
Spleen tyrosine kinase inhibitors reduce CD40L-induced proliferation of chronic lymphocytic leukemia cells but not normal B cells
Haematologica, 101 (2), e59-62
DOI 10.3324/haematol.2015.135590, PubMed 26589914

Publications 2014

Skånland SS, Moltu K, Berge T, Aandahl EM, Taskén K (2014)
T-cell co-stimulation through the CD2 and CD28 co-receptors induces distinct signalling responses
Biochem J, 460 (3), 399-410
DOI 10.1042/BJ20140040, PubMed 24665965

Publications 2013

Gregers TF, Skånland SS, Wälchli S, Bakke O, Sandvig K (2013)
BiP negatively affects ricin transport
Toxins (Basel), 5 (5), 969-82
DOI 10.3390/toxins5050969, PubMed 23666197

Publications 2012

Kalland ME, Solheim SA, Skånland SS, Taskén K, Berge T (2012)
Modulation of proximal signaling in normal and transformed B cells by transmembrane adapter Cbp/PAG
Exp Cell Res, 318 (14), 1611-9
DOI 10.1016/j.yexcr.2012.05.014, PubMed 22659621

Pollheimer J, Bodin J, Sundnes O, Edelmann RJ, Skånland SS, Sponheim J, Brox MJ, Sundlisaeter E, Loos T, Vatn M, Kasprzycka M, Wang J, Küchler AM, Taskén K, Haraldsen G, Hol J (2012)
Interleukin-33 drives a proinflammatory endothelial activation that selectively targets nonquiescent cells
Arterioscler Thromb Vasc Biol, 33 (2), e47-55
DOI 10.1161/ATVBAHA.112.253427, PubMed 23162017

Tcatchoff L, Andersson S, Utskarpen A, Klokk TI, Skånland SS, Pust S, Gerke V, Sandvig K (2012)
Annexin A1 and A2: roles in retrograde trafficking of Shiga toxin
PLoS One, 7 (7), e40429
DOI 10.1371/journal.pone.0040429, PubMed 22792315

Publications 2011

Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I (2011)
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
Nature, 471 (7340), 637-41
DOI 10.1038/nature09814, PubMed 21455181

Publications 2010

Bethani I, Skånland SS, Dikic I, Acker-Palmer A (2010)
Spatial organization of transmembrane receptor signalling
EMBO J, 29 (16), 2677-88
DOI 10.1038/emboj.2010.175, PubMed 20717138

Publications 2009

Skånland SS, Wälchli S, Brech A, Sandvig K (2009)
SNX4 in complex with clathrin and dynein: implications for endosome movement
PLoS One, 4 (6), e5935
DOI 10.1371/journal.pone.0005935, PubMed 19529763

Skånland SS, Wälchli S, Sandvig K (2009)
β-arrestins attenuate p38-mediated endosome to Golgi transport
Cell Microbiol, 11 (5), 796-807
DOI 10.1111/j.1462-5822.2009.01292.x, PubMed 19159388

Wälchli S, Aasheim HC, Skånland SS, Spilsberg B, Torgersen ML, Rosendal KR, Sandvig K (2009)
Characterization of clathrin and Syk interaction upon Shiga toxin binding
Cell Signal, 21 (7), 1161-8
DOI 10.1016/j.cellsig.2009.03.005, PubMed 19289168

Publications 2008

Skånland SS (2008)
Mechanisms in intracellular transport of toxins
In Series of dissertations submitted to the Faculty of Mathematics and Natural Sciences, University of Oslo, The Faculty, Oslo, nr. 818, 1 b. (flere pag.)
BIBSYS 090016602

Publications 2007

Ménétret JF, Schaletzky J, Clemons WM, Osborne AR, Skånland SS, Denison C, Gygi SP, Kirkpatrick DS, Park E, Ludtke SJ, Rapoport TA, Akey CW (2007)
Ribosome binding of a single copy of the SecY complex: implications for protein translocation
Mol Cell, 28 (6), 1083-92
DOI 10.1016/j.molcel.2007.10.034, PubMed 18158904

Skånland SS, Wälchli S, Utskarpen A, Wandinger-Ness A, Sandvig K (2007)
Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins
Traffic, 8 (3), 297-309
DOI 10.1111/j.1600-0854.2006.00527.x, PubMed 17319803

Torgersen ML, Wälchli S, Grimmer S, Skånland SS, Sandvig K (2007)
Protein kinase Cdelta is activated by Shiga toxin and regulates its transport
J Biol Chem, 282 (22), 16317-28
DOI 10.1074/jbc.M610886200, PubMed 17403690

Utskarpen A, Slagsvold HH, Dyve AB, Skånland SS, Sandvig K (2007)
SNX1 and SNX2 mediate retrograde transport of Shiga toxin
Biochem Biophys Res Commun, 358 (2), 566-70
DOI 10.1016/j.bbrc.2007.04.159, PubMed 17498660

Wälchli S, Skånland SS, Gregers TF, Lauvrak SU, Torgersen ML, Ying M, Kuroda S, Maturana A, Sandvig K (2007)
The Mitogen-activated protein kinase p38 links Shiga Toxin-dependent signaling and trafficking
Mol Biol Cell, 19 (1), 95-104
DOI 10.1091/mbc.e07-06-0565, PubMed 17959827

Publications 2005

Skånland SS (2005)
The PI 3-kinase hVps34 modulates endosomes to Golgi transport of ricin
S.S. Skånland, Oslo, 47, 23 s.
BIBSYS 050613553

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