Mucosal Immunology and Cancer Research
Publications 2024
Correction to: Separate Gut Plasma Cell Populations Produce Auto-Antibodies against Transglutaminase 2 and Transglutaminase 3 in Dermatitis Herpetiformis
Adv Sci (Weinh), 11 (21), e2400894
DOI 10.1002/advs.202400894, PubMed 38477397
The prognostic effect of tumor-associated macrophages in stage I-III colorectal cancer depends on T cell infiltration
Cell Oncol (Dordr), 47 (4), 1267-1276
DOI 10.1007/s13402-024-00926-w, PubMed 38407700
Allogeneic bone marrow transplantation for patients with treatment-refractory Crohn's Disease
Heliyon, 10 (1), e24026
DOI 10.1016/j.heliyon.2024.e24026, PubMed 38283244
Bin2cell reconstructs cells from high resolution Visium HD data
Bioinformatics, 40 (9)
DOI 10.1093/bioinformatics/btae546, PubMed 39250728
Publications 2023
Human small intestine contains 2 functionally distinct regulatory T-cell subsets
J Allergy Clin Immunol, 152 (1), 278-289.e6
DOI 10.1016/j.jaci.2023.02.030, PubMed 36893861
Separate Gut Plasma Cell Populations Produce Auto-Antibodies against Transglutaminase 2 and Transglutaminase 3 in Dermatitis Herpetiformis
Adv Sci (Weinh), 10 (25), e2300401
DOI 10.1002/advs.202300401, PubMed 37424036
A Roadmap for the Human Gut Cell Atlas
Nat Rev Gastroenterol Hepatol, 20 (9), 597-614
DOI 10.1038/s41575-023-00784-1, PubMed 37258747
Publications 2022
Single cell transcriptomic analysis of the immune cell compartment in the human small intestine and in Celiac disease
Nat Commun, 13 (1), 4920
DOI 10.1038/s41467-022-32691-5, PubMed 35995787
Single-cell transcriptomic analysis of human colonic macrophages reveals niche-specific subsets
J Exp Med, 219 (3)
DOI 10.1084/jem.20211846, PubMed 35139155
Cellsnake: a user-friendly tool for single-cell RNA sequencing analysis
Gigascience, 12
DOI 10.1093/gigascience/giad091, PubMed 37889009
Calprotectin Expressing Donor-Derived Macrophages Increase in Acute Gastrointestinal Graft-Versus-Host Disease
Transplant Cell Ther, 28 (5), 248.e1-248.e8
DOI 10.1016/j.jtct.2022.01.028, PubMed 35144036
Publications 2021
Response to Lauro and Zorzetti
Mucosal Immunol, 14 (6), 1395-1396
DOI 10.1038/s41385-021-00454-y, PubMed 34535772
Legends of allergology and immunology: Per Brandtzaeg - Pillar of mucosal immunology
Allergy, 76 (8), 2634-2635
DOI 10.1111/all.14824, PubMed 33752264
Lung CD4+ T-cells in patients with lung fibrosis produce pro-fibrotic interleukin-13 together with interferon-γ
Eur Respir J, 57 (3)
DOI 10.1183/13993003.00983-2020, PubMed 33154027
Publications 2020
CD4+ T cells persist for years in the human small intestine and display a TH1 cytokine profile
Mucosal Immunol, 14 (2), 402-410
DOI 10.1038/s41385-020-0315-5, PubMed 32572129
Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease
J Clin Invest, 130 (9), 4624-4636
DOI 10.1172/JCI129965, PubMed 32516138
Publications 2019
Resident memory CD8 T cells persist for years in human small intestine
J Exp Med, 216 (10), 2412-2426
DOI 10.1084/jem.20190414, PubMed 31337737
Characterisation of the endocrine pancreas in type 1 diabetes: islet size is maintained but islet number is markedly reduced
J Pathol Clin Res, 5 (4), 248-255
DOI 10.1002/cjp2.140, PubMed 31493350
Publications 2018
Monocytes accumulate in the airways of children with fatal asthma
Clin Exp Allergy, 48 (12), 1631-1639
DOI 10.1111/cea.13265, PubMed 30184280
Plasma Cells Are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients With Celiac Disease
Gastroenterology, 156 (5), 1428-1439.e10
DOI 10.1053/j.gastro.2018.12.013, PubMed 30593798
Transcriptional profiling reveals monocyte-related macrophages phenotypically resembling DC in human intestine
Mucosal Immunol, 11 (5), 1512-1523
DOI 10.1038/s41385-018-0060-1, PubMed 30038215
Oral exposure to the free amino acid glycine inhibits the acute allergic response in a model of cow's milk allergy in mice
Nutr Res, 58, 95-105
DOI 10.1016/j.nutres.2018.07.005, PubMed 30340819
Publications 2017
Transcriptional and functional profiling defines human small intestinal macrophage subsets
J Exp Med, 215 (2), 441-458
DOI 10.1084/jem.20170057, PubMed 29273642
Do Long-Lived Plasma Cells Maintain a Healthy Microbiota in the Gut?
Trends Immunol, 39 (3), 196-208
DOI 10.1016/j.it.2017.10.006, PubMed 29162322
Antibody-secreting plasma cells persist for decades in human intestine
J Exp Med, 214 (2), 309-317
DOI 10.1084/jem.20161590, PubMed 28104812
Immunohistology and remodeling in fatal pediatric and adolescent asthma
Respir Res, 18 (1), 94
DOI 10.1186/s12931-017-0575-0, PubMed 28511697
Publications 2016
Characterization of Regulatory T-Cell Markers in CD4+ T Cells of the Upper Airway Mucosa
PLoS One, 11 (2), e0148826
DOI 10.1371/journal.pone.0148826, PubMed 26866695
Rapid recruitment of CD14(+) monocytes in experimentally induced allergic rhinitis in human subjects
J Allergy Clin Immunol, 137 (6), 1872-1881.e12
DOI 10.1016/j.jaci.2015.11.025, PubMed 26851967
Long-term persistence of human donor alveolar macrophages in lung transplant recipients
Thorax, 71 (11), 1006-1011
DOI 10.1136/thoraxjnl-2016-208292, PubMed 27329043
Obituary - In Memoriam Per Brandtzaeg
Scand J Immunol, 84 (6), 370-372
DOI 10.1111/sji.12505, PubMed 28025869
CD1c-Expression by Monocytes - Implications for the Use of Commercial CD1c+ Dendritic Cell Isolation Kits
PLoS One, 11 (6), e0157387
DOI 10.1371/journal.pone.0157387, PubMed 27311059
Publications 2015
Ichthyosis prematurity syndrome caused by a novel missense mutation in FATP4 gene-a case report from India
Clin Case Rep, 4 (1), 87-9
DOI 10.1002/ccr3.462, PubMed 26783444
Insulitis and characterisation of infiltrating T cells in surgical pancreatic tail resections from patients at onset of type 1 diabetes
Diabetologia, 59 (3), 492-501
DOI 10.1007/s00125-015-3820-4, PubMed 26602422
IL-5 production by resident mucosal allergen-specific T cells in an explant model of allergic rhinitis
Clin Exp Allergy, 45 (8), 1296-304
DOI 10.1111/cea.12543, PubMed 25817862
Publications 2014
The short form of TSLP is constitutively translated in human keratinocytes and has characteristics of an antimicrobial peptide
Mucosal Immunol, 8 (1), 49-56
DOI 10.1038/mi.2014.41, PubMed 24850429
A role for CCL28-CCR3 in T-cell homing to the human upper airway mucosa
Mucosal Immunol, 8 (1), 107-14
DOI 10.1038/mi.2014.46, PubMed 24917456
Immunological changes and increased expression of myxovirus resistance protein a in thyroid tissue of patients with recent onset and untreated Graves' disease
Thyroid, 24 (3), 537-44
DOI 10.1089/thy.2013.0287, PubMed 24032645
The frequencies of IFNγ+IL2+TNFα+ PPD-specific CD4+CD45RO+ T-cells correlate with the magnitude of the QuantiFERON® gold in-tube response in a prospective study of healthy indian adolescents
PLoS One, 9 (7), e101224
DOI 10.1371/journal.pone.0101224, PubMed 24992314
Lung function, airway remodeling, and inflammation in infants: outcome at 8 years
Ann Allergy Asthma Immunol, 114 (2), 90-6
DOI 10.1016/j.anai.2014.09.019, PubMed 25455519
A thymic stromal lymphopoietin-responsive dendritic cell subset mediates allergic responses in the upper airway mucosa
J Allergy Clin Immunol, 134 (3), 613-621.e7
DOI 10.1016/j.jaci.2014.05.010, PubMed 24958565
Publications 2013
Mucosal cytokine response after short-term gluten challenge in celiac disease and non-celiac gluten sensitivity
Am J Gastroenterol, 108 (5), 842-50
DOI 10.1038/ajg.2013.91, PubMed 23588237
Inflammation and increased myxovirus resistance protein A expression in thyroid tissue in the early stages of Hashimoto's thyroiditis
Thyroid, 23 (3), 334-41
DOI 10.1089/thy.2012.0264, PubMed 22998463
Plasmacytoid dendritic cells are scarcely represented in the human gut mucosa and are not recruited to the celiac lesion
Mucosal Immunol, 6 (5), 985-92
DOI 10.1038/mi.2012.136, PubMed 23340820
Publications 2012
Rapid accumulation of CD14+CD11c+ dendritic cells in gut mucosa of celiac disease after in vivo gluten challenge
PLoS One, 7 (3), e33556
DOI 10.1371/journal.pone.0033556, PubMed 22438948
Prenatal sonographic assessment and perinatal course of ichthyosis prematurity syndrome
Ultrasound Obstet Gynecol, 39 (4), 473-7
DOI 10.1002/uog.9014, PubMed 21465607
Serum response factor controls transcriptional network regulating epidermal function and hair follicle morphogenesis
J Invest Dermatol, 133 (3), 608-617
DOI 10.1038/jid.2012.378, PubMed 23151848
Research needs in allergy: an EAACI position paper, in collaboration with EFA
Clin Transl Allergy, 2 (1), 21
DOI 10.1186/2045-7022-2-21, PubMed 23121771
Epithelial-microbial crosstalk in polymeric Ig receptor deficient mice
Eur J Immunol, 42 (11), 2959-70
DOI 10.1002/eji.201242543, PubMed 22865203
Publications 2011
Density of CD163+ CD11c+ dendritic cells increases and CD103+ dendritic cells decreases in the coeliac lesion
Scand J Immunol, 74 (2), 186-94
DOI 10.1111/j.1365-3083.2011.02549.x, PubMed 21392045
Assessing possible celiac disease by an HLA-DQ2-gliadin Tetramer Test
Am J Gastroenterol, 106 (7), 1318-24
DOI 10.1038/ajg.2011.23, PubMed 21364548
Sun exposure rapidly reduces plasmacytoid dendritic cells and inflammatory dermal dendritic cells in psoriatic skin
Br J Dermatol, 165 (4), 792-801
DOI 10.1111/j.1365-2133.2011.10430.x, PubMed 21623747
Ichthyosis prematurity syndrome caused by a novel fatty acid transport protein 4 gene mutation in a German infant
Arch Dermatol, 147 (6), 750-2
DOI 10.1001/archdermatol.2011.139, PubMed 21690550
Role of fatty acid transporters in epidermis: Implications for health and disease
Dermatoendocrinol, 3 (2), 53-61
DOI 10.4161/derm.3.2.14816, PubMed 21695012
Ichthyosis prematurity syndrome: clinical evaluation of 17 families with a rare disorder of lipid metabolism
J Am Acad Dermatol, 66 (4), 606-16
DOI 10.1016/j.jaad.2011.04.014, PubMed 21856041
Depletion of murine intestinal microbiota: effects on gut mucosa and epithelial gene expression
PLoS One, 6 (3), e17996
DOI 10.1371/journal.pone.0017996, PubMed 21445311
Experimentally induced accumulation of Foxp3⁺ T cells in upper airway allergy
Clin Exp Allergy, 41 (7), 954-62
DOI 10.1111/j.1365-2222.2011.03710.x, PubMed 21418344
Sun exposure induces rapid immunological changes in skin and peripheral blood in patients with psoriasis
Br J Dermatol, 164 (2), 344-55
DOI 10.1111/j.1365-2133.2010.10149.x, PubMed 21271993
Publications 2010
Characterisation of bronchus-associated lymphoid tissue and antigen-presenting cells in central airway mucosa of children
Thorax, 66 (2), 151-6
DOI 10.1136/thx.2010.149591, PubMed 21163807
Publications 2009
Pathogenic mechanisms of allergic inflammation: atopic asthma as a paradigm
Adv Immunol, 104, 51-113
DOI 10.1016/S0065-2776(08)04003-0, PubMed 20457116
Publications 2008
Depletion of CD4+ CD25+ regulatory T cells inhibits local tumour growth in a mouse model of B cell lymphoma
Clin Exp Immunol, 152 (2), 381-7
DOI 10.1111/j.1365-2249.2008.03642.x, PubMed 18341610
Bronchial response pattern of antigen presenting cells and regulatory T cells in children less than 2 years of age
Thorax, 63 (8), 703-9
DOI 10.1136/thx.2007.082974, PubMed 18250182
Regulation of immunological homeostasis in the respiratory tract
Nat Rev Immunol, 8 (2), 142-52
DOI 10.1038/nri2236, PubMed 18204469
Depletion of CD4+CD25+CD127lo regulatory T cells does not increase allergen-driven T cell activation
Clin Exp Allergy, 38 (11), 1752-9
DOI 10.1111/j.1365-2222.2008.03081.x, PubMed 18681851
Publications 2007
Surface expression of transglutaminase 2 by dendritic cells and its potential role for uptake and presentation of gluten peptides to T cells
Scand J Immunol, 65 (3), 213-20
DOI 10.1111/j.1365-3083.2006.01881.x, PubMed 17309775
Regulatory T cells in colorectal cancer patients suppress anti-tumor immune activity in a COX-2 dependent manner
Cancer Immunol Immunother, 57 (6), 813-21
DOI 10.1007/s00262-007-0417-x, PubMed 17962941
Publications 2006
Plasmacytoid dendritic cells induce a distinct cytokine pattern in virus-specific CD4+ memory T cells that is modulated by CpG oligodeoxynucleotides
Scand J Immunol, 64 (4), 404-11
DOI 10.1111/j.1365-3083.2006.01792.x, PubMed 16970682
Human dendritic cell expression of HLA-DO is subset specific and regulated by maturation
J Immunol, 176 (6), 3536-47
DOI 10.4049/jimmunol.176.6.3536, PubMed 16517722
Accelerated antigen sampling and transport by airway mucosal dendritic cells following inhalation of a bacterial stimulus
J Immunol, 177 (9), 5861-7
DOI 10.4049/jimmunol.177.9.5861, PubMed 17056510
Plasmacytoid DCs regulate recall responses by rapid induction of IL-10 in memory T cells
Blood, 109 (8), 3369-76
DOI 10.1182/blood-2006-06-031484, PubMed 17158235
A unique dendritic cell subset accumulates in the celiac lesion and efficiently activates gluten-reactive T cells
Gastroenterology, 131 (2), 428-38
DOI 10.1053/j.gastro.2006.06.002, PubMed 16890596
Publications 2005
Differential capability for phagocytosis of apoptotic and necrotic leukemia cells by human peripheral blood dendritic cell subsets
J Leukoc Biol, 77 (5), 689-98
DOI 10.1189/jlb.1204711, PubMed 15728242
CD11c+ dendritic cells and plasmacytoid DCs are activated by human cytomegalovirus and retain efficient T cell-stimulatory capability upon infection
Blood, 107 (5), 2022-9
DOI 10.1182/blood-2005-05-2016, PubMed 16269620
Cerebral thrombotic microangiopathy and antiphospholipid antibodies in Aicardi-Goutieres syndrome--report of two sisters
Neuropediatrics, 36 (1), 40-4
DOI 10.1055/s-2004-830532, PubMed 15776321
Publications 2004
Plasmacytoid dendritic cells activate allergen-specific TH2 memory cells: modulation by CpG oligodeoxynucleotides
J Allergy Clin Immunol, 114 (2), 436-43
DOI 10.1016/j.jaci.2004.04.035, PubMed 15316529
The CMRF58 antibody recognizes a subset of CD123hi dendritic cells in allergen-challenged mucosa
J Leukoc Biol, 77 (3), 344-51
DOI 10.1189/jlb.1004559, PubMed 15569693
Publications 2003
[Pulmonary veno-occlusive disease in a patient with scleroderma and the CREST syndrome]
Tidsskr Nor Laegeforen, 123 (23), 3391-2
PubMed 14713977
Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules
Am J Pathol, 163 (1), 69-79
DOI 10.1016/S0002-9440(10)63631-0, PubMed 12819012
Endothelial cell diversity revealed by global expression profiling
Proc Natl Acad Sci U S A, 100 (19), 10623-8
DOI 10.1073/pnas.1434429100, PubMed 12963823
Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma
J Exp Med, 198 (1), 19-30
DOI 10.1084/jem.20021328, PubMed 12835476
Human nasal mucosa contains antigen-presenting cells of strikingly different functional phenotypes
Am J Respir Cell Mol Biol, 30 (1), 31-7
DOI 10.1165/rcmb.2002-0230OC, PubMed 12829449
Publications 2002
Involvement of plasmacytoid dendritic cells in human diseases
Hum Immunol, 63 (12), 1201-5
DOI 10.1016/s0198-8859(02)00759-0, PubMed 12480264
A site-specific plectin mutation causes dominant epidermolysis bullosa simplex Ogna: two identical de novo mutations
J Invest Dermatol, 118 (1), 87-93
DOI 10.1046/j.0022-202x.2001.01591.x, PubMed 11851880
Publications 2001
Plasmacytoid dendritic cells (natural interferon- alpha/beta-producing cells) accumulate in cutaneous lupus erythematosus lesions
Am J Pathol, 159 (1), 237-43
DOI 10.1016/s0002-9440(10)61689-6, PubMed 11438470
Rapid dendritic cell recruitment to the bronchial mucosa of patients with atopic asthma in response to local allergen challenge
Thorax, 56 (11), 823-6
DOI 10.1136/thorax.56.11.823, PubMed 11641504
Publications 2000
Immunohistochemistry in research and diagnosis of celiac disease
Methods Mol Med, 41, 203-39
DOI 10.1385/1-59259-082-9:203, PubMed 21374442
Experimentally induced recruitment of plasmacytoid (CD123high) dendritic cells in human nasal allergy
J Immunol, 165 (7), 4062-8
DOI 10.4049/jimmunol.165.7.4062, PubMed 11034417
Publications 1999
Culture characterization of differentiated high endothelial venule cells from human tonsils
Lab Invest, 79 (3), 327-36
PubMed 10092069
Regional specialization in the mucosal immune system: what happens in the microcompartments?
Immunol Today, 20 (3), 141-51
DOI 10.1016/s0167-5699(98)01413-3, PubMed 10203706
Antigen presentation and stimulation of the immune system in human airways
Allergy, 54 Suppl 57, 37-49
DOI 10.1111/j.1398-9995.1999.tb04405.x, PubMed 10565479
Glucocorticosteroids inhibit mRNA expression for eotaxin, eotaxin-2, and monocyte-chemotactic protein-4 in human airway inflammation with eosinophilia
J Immunol, 163 (3), 1545-51
PubMed 10415058
Publications 1998
Cellular and molecular mechanisms for induction of mucosal immunity
Dev Biol Stand, 92, 93-108
PubMed 9554262
Phenotypic distribution of T cells in human nasal mucosa differs from that in the gut
Am J Respir Cell Mol Biol, 18 (3), 392-401
DOI 10.1165/ajrcmb.18.3.2995, PubMed 9490657
Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease
Gastroenterology, 115 (3), 551-63
DOI 10.1016/s0016-5085(98)70134-9, PubMed 9721152
Cytokine profiles of cultured microvascular endothelial cells from the human intestine
Gut, 42 (5), 635-42
DOI 10.1136/gut.42.5.635, PubMed 9659156
Rapid secretion of prestored interleukin 8 from Weibel-Palade bodies of microvascular endothelial cells
J Exp Med, 188 (9), 1751-6
DOI 10.1084/jem.188.9.1751, PubMed 9802986
Publications 1997
Mucosal immunity--a major adaptive defence mechanism
Behring Inst Mitt (98), 1-23
PubMed 9382729
Mucosal immunology of the upper airways: an overview
Ann N Y Acad Sci, 830, 1-18
DOI 10.1111/j.1749-6632.1997.tb51875.x, PubMed 9616663
Eosinophils and T cells in fatal asthma
Am J Respir Crit Care Med, 155 (3), 1167-8
DOI 10.1164/ajrccm.155.3.9117005, PubMed 9117005
Expression of functional VCAM-1 by cultured nasal polyp-derived microvascular endothelium
Am J Pathol, 150 (6), 2113-23
PubMed 9176402
Plectin abnormality in epidermolysis bullosa simplex Ogna: non-responsiveness of basal keratinocytes to some anti-rat plectin antibodies
Exp Dermatol, 6 (1), 41-8
DOI 10.1111/j.1600-0625.1997.tb00144.x, PubMed 9067706
Publications 1996
Immune functions and immunopathology of the mucosa of the upper respiratory pathways
Acta Otolaryngol, 116 (2), 149-59
DOI 10.3109/00016489609137812, PubMed 8725503
Publications 1995
Immunostaining with monoclonal antibodies to eosinophil cationic protein (EG1 and EG2) does not distinguish between resting and activated eosinophils in formalin-fixed tissue specimens
Adv Exp Med Biol, 371A, 283-6
DOI 10.1007/978-1-4615-1941-6_59, PubMed 8525926
Monoclonal antibody EG2 reactivity cannot be used as an immunohistochemical activation marker for eosinophils
J Leukoc Biol, 57 (3), 513-4
DOI 10.1002/jlb.57.3.513, PubMed 7884325
Eosinophil infiltration is related to increased expression of vascular cell adhesion molecule-1 in nasal polyps
Am J Respir Cell Mol Biol, 12 (6), 624-32
DOI 10.1165/ajrcmb.12.6.7539273, PubMed 7539273
Publications 1994
Monoclonal antibody EG2 does not provide reliable immunohistochemical discrimination between resting and activated eosinophils
J Immunol Methods, 175 (1), 23-36
DOI 10.1016/0022-1759(94)90328-x, PubMed 7930638
Erroneous immunohistochemical application of monoclonal antibody EG2 to detect cellular activation
Lancet, 344 (8935), 1514-5
DOI 10.1016/s0140-6736(94)90336-0, PubMed 7968154
Differential interference contrast microscopy combined with immunofluorescence: a new method to phenotype eosinophils in situ
J Immunol Methods, 173 (1), 77-91
DOI 10.1016/0022-1759(94)90285-2, PubMed 8034989
Publications 1993
Distribution of macrophages and granulocytes expressing L1 protein (calprotectin) in human Peyer's patches compared with normal ileal lamina propria and mesenteric lymph nodes
Gut, 34 (10), 1357-63
DOI 10.1136/gut.34.10.1357, PubMed 8244101