Publications 2024

Díez-Sánchez A, Lindholm HT, Vornewald PM, Ostrop J, Yao R, Single AB, Marstad A, Parmar N, Shaw TN, Martín-Alonso M, Oudhoff MJ (2024)
LSD1 drives intestinal epithelial maturation and controls small intestinal immune cell composition independent of microbiota in a murine model
Nat Commun, 15 (1), 3412
DOI 10.1038/s41467-024-47815-2, PubMed 38649356

Publications 2023

Das S, Stamnaes J, Kemppainen E, Hervonen K, Lundin KEA, Parmar N, Jahnsen FL, Jahnsen J, Lindfors K, Salmi T, Iversen R, Sollid LM (2023)
Separate Gut Plasma Cell Populations Produce Auto-Antibodies against Transglutaminase 2 and Transglutaminase 3 in Dermatitis Herpetiformis
Adv Sci (Weinh), 10 (25), e2300401
DOI 10.1002/advs.202300401, PubMed 37424036

Vornewald PM, Forman R, Yao R, Parmar N, Lindholm HT, Lee LSK, Martín-Alonso M, Else KJ, Oudhoff MJ (2023)
Mmp17-deficient mice exhibit heightened goblet cell effector expression in the colon and increased resistance to chronic Trichuris muris infection
Front Immunol, 14, 1243528
DOI 10.3389/fimmu.2023.1243528, PubMed 37869014

Publications 2022

Lindholm HT, Parmar N, Drurey C, Campillo Poveda M, Vornewald PM, Ostrop J, Díez-Sanchez A, Maizels RM, Oudhoff MJ (2022)
BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia
Sci Immunol, 7 (71), eabl6543
DOI 10.1126/sciimmunol.abl6543, PubMed 35559665

Publications 2021

Chandrakar P, Seth A, Rani A, Dutta M, Parmar N, Descoteaux A, Kar S (2021)
Jagged-Notch-mediated divergence of immune cell crosstalk maintains the anti-inflammatory response in visceral leishmaniasis
J Cell Sci, 134 (5)
DOI 10.1242/jcs.252494, PubMed 33589499

Mishra S, Parmar N, Chandrakar P, Sharma CP, Parveen S, Vats RP, Seth A, Goel A, Kar S (2021)
Design, synthesis, in vitro and in vivo biological evaluation of pyranone-piperazine analogs as potent antileishmanial agents
Eur J Med Chem, 221, 113516
DOI 10.1016/j.ejmech.2021.113516, PubMed 33992928

Ostrop J, Zwiggelaar RT, Terndrup Pedersen M, Gerbe F, Bösl K, Lindholm HT, Díez-Sánchez A, Parmar N, Radetzki S, von Kries JP, Jay P, Jensen KB, Arrowsmith C, Oudhoff MJ (2021)
A Semi-automated Organoid Screening Method Demonstrates Epigenetic Control of Intestinal Epithelial Differentiation
Front Cell Dev Biol, 8, 618552
DOI 10.3389/fcell.2020.618552, PubMed 33575256

Parmar N, Burrows K, Vornewald PM, Lindholm HT, Zwiggelaar RT, Díez-Sánchez A, Martín-Alonso M, Fosslie M, Vallance BA, Dahl JA, Zaph C, Oudhoff MJ (2021)
Intestinal-epithelial LSD1 controls goblet cell maturation and effector responses required for gut immunity to bacterial and helminth infection
PLoS Pathog, 17 (3), e1009476
DOI 10.1371/journal.ppat.1009476, PubMed 33788902

Roberts LB, Schnoeller C, Berkachy R, Darby M, Pillaye J, Oudhoff MJ, Parmar N, Mackowiak C, Sedda D, Quesniaux V, Ryffel B, Vaux R, Gounaris K, Berrard S, Withers DR, Horsnell WGC, Selkirk ME (2021)
Acetylcholine production by group 2 innate lymphoid cells promotes mucosal immunity to helminths
Sci Immunol, 6 (57)
DOI 10.1126/sciimmunol.abd0359, PubMed 33674321

Publications 2020

Parmar N, Chandrakar P, Kar S (2020)
Leishmania donovani Subverts Host Immune Response by Epigenetic Reprogramming of Macrophage M(Lipopolysaccharides + IFN-γ)/M(IL-10) Polarization
J Immunol, 204 (10), 2762-2778
DOI 10.4049/jimmunol.1900251, PubMed 32277055

Verma SK, Joseph SK, Verma R, Kushwaha V, Parmar N, Yadav PK, Thota JR, Kar S, Murthy PK (2020)
Corrigendum to 'Protection against filarial infection by 45-49 kDa molecules of Brugia malayi via IFN-γ-mediated iNOS induction' [Vaccine 33 (2015) 527-534]
Vaccine, 38 (32), 5076
DOI 10.1016/j.vaccine.2020.05.041, PubMed 32517851

Zwiggelaar RT, Lindholm HT, Fosslie M, Terndrup Pedersen M, Ohta Y, Díez-Sánchez A, Martín-Alonso M, Ostrop J, Matano M, Parmar N, Kvaløy E, Spanjers RR, Nazmi K, Rye M, Drabløs F, Arrowsmith C, Arne Dahl J, Jensen KB, Sato T, Oudhoff MJ (2020)
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium
Sci Adv, 6 (37)
DOI 10.1126/sciadv.abc0367, PubMed 32917713

Publications 2019

Chandrakar P, Gunaganti N, Parmar N, Kumar A, Singh SK, Rashid M, Wahajuddin M, Mitra K, Narender T, Kar S (2019)
β-Amino acid derivatives as mitochondrial complex III inhibitors of L. donovani: A promising chemotype targeting visceral leishmaniasis
Eur J Med Chem, 182, 111632
DOI 10.1016/j.ejmech.2019.111632, PubMed 31499363

Chandrakar P, Parmar N, Descoteaux A, Kar S (2019)
Differential Induction of SOCS Isoforms by Leishmania donovani Impairs Macrophage-T Cell Cross-Talk and Host Defense
J Immunol, 204 (3), 596-610
DOI 10.4049/jimmunol.1900412, PubMed 31882519

Upadhyay A, Chandrakar P, Gupta S, Parmar N, Singh SK, Rashid M, Kushwaha P, Wahajuddin M, Sashidhara KV, Kar S (2019)
Synthesis, Biological Evaluation, Structure-Activity Relationship, and Mechanism of Action Studies of Quinoline-Metronidazole Derivatives Against Experimental Visceral Leishmaniasis
J Med Chem, 62 (11), 5655-5671
DOI 10.1021/acs.jmedchem.9b00628, PubMed 31124675

Yadav PK, Chandrakar P, Sharma P, Vishwakarma P, Parmar N, Srivastava M, Kar S (2019)
Reciprocal changes in CD11c⁺CD11b⁺ and CD11c⁺CD8α⁺ dendritic cell subsets determine protective or permissive immune response in murine experimental VL
Vaccine, 38 (2), 355-365
DOI 10.1016/j.vaccine.2019.10.004, PubMed 31648908

Publications 2018

Parmar N, Chandrakar P, Vishwakarma P, Singh K, Mitra K, Kar S (2018)
Leishmania donovani Exploits Tollip, a Multitasking Protein, To Impair TLR/IL-1R Signaling for Its Survival in the Host
J Immunol, 201 (3), 957-970
DOI 10.4049/jimmunol.1800062, PubMed 29907707

Verma R, Kushwaha V, Pandey S, Thota JR, Vishwakarma P, Parmar N, Yadav PK, Tewari P, Kar S, Shukla PK, Murthy PK (2018)
Leishmania donovani molecules recognized by sera of filaria infected host facilitate filarial infection
Parasitol Res, 117 (9), 2901-2912
DOI 10.1007/s00436-018-5981-9, PubMed 29946763

Publications 2017

Anand D, Yadav PK, Patel OP, Parmar N, Maurya RK, Vishwakarma P, Raju KS, Taneja I, Wahajuddin M, Kar S, Yadav PP (2017)
Antileishmanial Activity of Pyrazolopyridine Derivatives and Their Potential as an Adjunct Therapy with Miltefosine
J Med Chem, 60 (3), 1041-1059
DOI 10.1021/acs.jmedchem.6b01447, PubMed 28059524

Vishwakarma P, Parmar N, Chandrakar P, Sharma T, Kathuria M, Agnihotri PK, Siddiqi MI, Mitra K, Kar S (2017)
Ammonium trichloro [1,2-ethanediolato-O,O']-tellurate cures experimental visceral leishmaniasis by redox modulation of Leishmania donovani trypanothione reductase and inhibiting host integrin linked PI3K/Akt pathway
Cell Mol Life Sci, 75 (3), 563-588
DOI 10.1007/s00018-017-2653-3, PubMed 28900667

Publications 2016

Vishwakarma P, Parmar N, Yadav PK, Chandrakar P, Kar S (2016)
15d-Prostaglandin J2 induced reactive oxygen species-mediated apoptosis during experimental visceral leishmaniasis
J Mol Med (Berl), 94 (6), 695-710
DOI 10.1007/s00109-016-1384-5, PubMed 26830627

Publications 2014

Shivahare R, Vishwakarma P, Parmar N, Yadav PK, Haq W, Srivastava M, Gupta S, Kar S (2014)
Combination of liposomal CpG oligodeoxynucleotide 2006 and miltefosine induces strong cell-mediated immunity during experimental visceral leishmaniasis
PLoS One, 9 (4), e94596
DOI 10.1371/journal.pone.0094596, PubMed 24732039

Verma SK, Joseph SK, Verma R, Kushwaha V, Parmar N, Yadav PK, Thota JR, Kar S, Murthy PK (2014)
Protection against filarial infection by 45-49 kDa molecules of Brugia malayi via IFN-γ-mediated iNOS induction
Vaccine, 33 (4), 527-34
DOI 10.1016/j.vaccine.2014.11.041, PubMed 25454090