Innate Lymphocyte Group

Publications 2024

Gjærde LK, Brück O, Gagelmann N, Gavriilaki E, Inngjerdingen M, Keranen M, Kisch A, Myhre AE, Olivieri A, Perez-Simon JA, Perovic D, Perovic V, Piekarska A, Pulanic D, Rathje K, Van Veen S, Dachy G, Moiseev I, Penack O, Peric Z, Greinix H, Lee SJ, Wolff D, Schoemans H (2024)
Standardized translations of the Lee Chronic GvHD Symptom Scale to 12 European languages: an EU COST Action cGvHD Eurograft project
Bone Marrow Transplant, 59 (10), 1477-1479
DOI 10.1038/s41409-024-02374-4, PubMed 39020019

Langer R, Lelas A, Rittenschober M, Piekarska A, Sadowska-Klasa A, Sabol I, Desnica L, Greinix H, Dickinson A, Inngjerdingen M, Lawitschka A, Vrhovac R, Pulanic D, Güneş S, Klein S, Moritz Middeke J, Grube M, Edinger M, Herr W, Wolff D (2024)
Retrospective analysis of the incidence and outcome of late acute and chronic graft-versus-host disease-an analysis from transplant centers across Europe
Front Transplant, 3, 1332181
DOI 10.3389/frtra.2024.1332181, PubMed 38993773

Mohamed WN, Butt HS, Schmidt TJ, Eltvik AA, Wu D, Malterud KE, Inngjerdingen M, Inngjerdingen KT, Wangensteen H (2024)
Biflavonoids and bi- and tricoumarins from Daphne mezereum and inhibition of TNF-α secretion
Phytochemistry, 229, 114308
DOI 10.1016/j.phytochem.2024.114308, PubMed 39433079

Ulvmoen A, Greiff V, Bechensteen AG, Inngjerdingen M (2024)
NKG2A discriminates natural killer cells with a suppressed phenotype in pediatric acute leukemia
J Leukoc Biol, 115 (2), 334-343
DOI 10.1093/jleuko/qiad112, PubMed 37738462

Publications 2023

Butt HS, Ulriksen ES, Rise F, Wangensteen H, Duus JØ, Inngjerdingen M, Inngjerdingen KT (2023)
Structural elucidation of novel pro-inflammatory polysaccharides from Daphne mezereum L
Carbohydr Polym, 324, 121554
DOI 10.1016/j.carbpol.2023.121554, PubMed 37985118

Gail LM, Schell KJ, Łacina P, Strobl J, Bolton SJ, Steinbakk Ulriksen E, Bogunia-Kubik K, Greinix H, Crossland RE, Inngjerdingen M, Stary G (2023)
Complex interactions of cellular players in chronic Graft-versus-Host Disease
Front Immunol, 14, 1199422
DOI 10.3389/fimmu.2023.1199422, PubMed 37435079

Saidu NEB, Aarsund M, Sørensen E, Stensland M, Nyman TA, Ulvmoen A, Wu Y, Inngjerdingen M (2023)
Identifying a core protein signature of small extracellular vesicles derived from B-cell precursor acute lymphoblastic leukaemia
Scand J Immunol, 99 (3), e13341
DOI 10.1111/sji.13341, PubMed 38441169

Publications 2022

Doglio M, Crossland RE, Alho AC, Penack O, Dickinson AM, Stary G, Lacerda JF, Eissner G, Inngjerdingen M (2022)
Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease
Front Immunol, 13, 1045168
DOI 10.3389/fimmu.2022.1045168, PubMed 36466922

Perovic V, Sabol I, Grce M, Inngjerdingen M, Pulanic D, Peric Z, Peczynski C, Polge E, Koenecke C, Dickinson A, Greinix H, Basak G, Penack O, Scherwath A, Barata A, Olivieri A, Lawitschka A, Mensah-Glanowska P, Andrikovics H, Schoemans H, Wolff D (2022)
Practice patterns in chronic graft-versus-host disease patient management and patient reported outcome measures across the EBMT allogeneic transplantation network
Bone Marrow Transplant, 57 (9), 1458-1460
DOI 10.1038/s41409-022-01733-3, PubMed 35690692

Skånland SS, Inngjerdingen M, Bendiksen H, York J, Spetalen S, Munthe LA, Tjønnfjord GE (2022)
Functional testing of relapsed chronic lymphocytic leukemia guides precision medicine and maps response and resistance mechanisms. An index case
Haematologica, 107 (8), 1994-1998
DOI 10.3324/haematol.2021.280393, PubMed 35236056

Sudworth A, Segers FM, Yilmaz B, Guslund NC, Macpherson AJ, Dissen E, Qiao SW, Inngjerdingen M (2022)
Innate lymphoid cell characterization in the rat and their correlation to gut commensal microbes
Eur J Immunol, 52 (5), 717-729
DOI 10.1002/eji.202149639, PubMed 35099074

Ulriksen ES, Butt HS, Ohrvik A, Blakeney RA, Kool A, Wangensteen H, Inngjerdingen M, Inngjerdingen KT (2022)
The discovery of novel immunomodulatory medicinal plants by combination of historical text reviews and immunological screening assays
J Ethnopharmacol, 296, 115402
DOI 10.1016/j.jep.2022.115402, PubMed 35640738

Zhang L, Ulriksen ES, Hoel H, Sandvik L, Malterud KE, Inngjerdingen KT, Inngjerdingen M, Wangensteen H (2022)
Phytochemical characterization and anti-inflammatory activity of a water extract of Gentiana purpurea roots
J Ethnopharmacol, 301, 115818
DOI 10.1016/j.jep.2022.115818, PubMed 36220509

Aarsund M, Nyman TA, Stensland ME, Wu Y, Inngjerdingen M (2022)
Isolation of a cytolytic subpopulation of extracellular vesicles derived from NK cells containing NKG7 and cytolytic proteins
Front Immunol, 13, 977353
DOI 10.3389/fimmu.2022.977353, PubMed 36189227

Aarsund M, Segers FM, Wu Y, Inngjerdingen M (2022)
Comparison of characteristics and tumor targeting properties of extracellular vesicles derived from primary NK cells or NK-cell lines stimulated with IL-15 or IL-12/15/18
Cancer Immunol Immunother, 71 (9), 2227-2238
DOI 10.1007/s00262-022-03161-0, PubMed 35119498

Publications 2020

Crossland RE, Perutelli F, Bogunia-Kubik K, Mooney N, Milutin Gašperov N, Pučić-Baković M, Greinix H, Weber D, Holler E, Pulanić D, Wolff D, Dickinson AM, Inngjerdingen M, Grce M (2020)
Potential Novel Biomarkers in Chronic Graft-Versus-Host Disease
Front Immunol, 11, 602547
DOI 10.3389/fimmu.2020.602547, PubMed 33424849

Farcas M, Inngjerdingen M (2020)
Natural killer cell-derived extracellular vesicles in cancer therapy
Scand J Immunol, 92 (4), e12938
DOI 10.1111/sji.12938, PubMed 32697853

Saidu NEB, Bonini C, Dickinson A, Grce M, Inngjerdingen M, Koehl U, Toubert A, Zeiser R, Galimberti S (2020)
New Approaches for the Treatment of Chronic Graft-Versus-Host Disease: Current Status and Future Directions
Front Immunol, 11, 578314
DOI 10.3389/fimmu.2020.578314, PubMed 33162993

Publications 2018

Sikorski K, Mehta A, Inngjerdingen M, Thakor F, Kling S, Kalina T, Nyman TA, Stensland ME, Zhou W, de Souza GA, Holden L, Stuchly J, Templin M, Lund-Johansen F (2018)
A high-throughput pipeline for validation of antibodies
Nat Methods, 15 (11), 909-912
DOI 10.1038/s41592-018-0179-8, PubMed 30377371

Publications 2017

Boieri M, Shah P, Jalapothu D, Zaitseva O, Walter L, Rolstad B, Naper C, Dressel R, Inngjerdingen M (2017)
Rat acute GvHD is Th1 driven and characterized by predominant donor CD4⁺ T-cell infiltration of skin and gut
Exp Hematol, 50, 33-45.e3
DOI 10.1016/j.exphem.2017.02.002, PubMed 28238806

Boieri M, Ulvmoen A, Sudworth A, Lendrem C, Collin M, Dickinson AM, Kveberg L, Inngjerdingen M (2017)
IL-12, IL-15, and IL-18 pre-activated NK cells target resistant T cell acute lymphoblastic leukemia and delay leukemia development in vivo
Oncoimmunology, 6 (3), e1274478
DOI 10.1080/2162402X.2016.1274478, PubMed 28405496

Braünlich PM, Inngjerdingen KT, Inngjerdingen M, Johnson Q, Paulsen BS, Mabusela W (2017)
Polysaccharides from the South African medicinal plant Artemisia afra: Structure and activity studies
Fitoterapia, 124, 182-187
DOI 10.1016/j.fitote.2017.11.016, PubMed 29155274

Sudworth A, Vaage JT, Inngjerdingen M, Kveberg L (2017)
Frontline Science: A hyporesponsive subset of rat NK cells negative for Ly49s3 and NKR-P1B are precursors to the functionally mature NKR-P1B⁺ subset
J Leukoc Biol, 102 (6), 1289-1298
DOI 10.1189/jlb.1HI0517-177RR, PubMed 28747319

Publications 2016

Boieri M, Shah P, Dressel R, Inngjerdingen M (2016)
The Role of Animal Models in the Study of Hematopoietic Stem Cell Transplantation and GvHD: A Historical Overview
Front Immunol, 7, 333
DOI 10.3389/fimmu.2016.00333, PubMed 27625651

Jalapothu D, Boieri M, Crossland RE, Shah P, Butt IA, Norden J, Dressel R, Dickinson AM, Inngjerdingen M (2016)
Tissue-Specific Expression Patterns of MicroRNA during Acute Graft-versus-Host Disease in the Rat
Front Immunol, 7, 361
DOI 10.3389/fimmu.2016.00361, PubMed 27695455

Lund-Johansen F, de la Rosa Carrillo D, Mehta A, Sikorski K, Inngjerdingen M, Kalina T, Røysland K, de Souza GA, Bradbury AR, Lecrevisse Q, Stuchly J (2016)
MetaMass, a tool for meta-analysis of subcellular proteomics data
Nat Methods, 13 (10), 837-40
DOI 10.1038/nmeth.3967, PubMed 27571551

Publications 2014

Kveberg L, Sudworth A, Todros-Dawda I, Inngjerdingen M, Vaage JT (2014)
Functional characterization of a conserved pair of NKR-P1 receptors expressed by NK cells and T lymphocytes in liver and gut
Eur J Immunol, 45 (2), 501-12
DOI 10.1002/eji.201444710, PubMed 25382546

Todros-Dawda I, Kveberg L, Vaage JT, Inngjerdingen M (2014)
The tetraspanin CD53 modulates responses from activating NK cell receptors, promoting LFA-1 activation and dampening NK cell effector functions
PLoS One, 9 (5), e97844
DOI 10.1371/journal.pone.0097844, PubMed 24832104

Publications 2013

Le Normand M, Mélida H, Holmbom B, Michaelsen TE, Inngjerdingen M, Bulone V, Paulsen BS, Ek M (2013)
Hot-water extracts from the inner bark of Norway spruce with immunomodulating activities
Carbohydr Polym, 101, 699-704
DOI 10.1016/j.carbpol.2013.09.067, PubMed 24299828

Publications 2012

Austarheim I, Christensen BE, Hegna IK, Petersen BO, Duus JO, Bye R, Michaelsen TE, Diallo D, Inngjerdingen M, Paulsen BS (2012)
Chemical and biological characterization of pectin-like polysaccharides from the bark of the Malian medicinal tree Cola cordifolia
Carbohydr Polym, 89 (1), 259-68
DOI 10.1016/j.carbpol.2012.03.005, PubMed 24750632

Inngjerdingen M, Kveberg L, Vaage JT (2012)
A novel NKR-P1B(bright) NK cell subset expresses an activated CD25(+)CX(3)CR1(+)CD62L(-)CD11b(-)CD27(-) phenotype and is prevalent in blood, liver, and gut-associated lymphoid organs of rats
J Immunol, 188 (6), 2499-508
DOI 10.4049/jimmunol.1003939, PubMed 22308308

Publications 2011

Glaeserud S, Gronhaug TE, Michaelsen TE, Inngjerdingen M, Barsett H, Diallo D, Paulsen BS (2011)
Immunomodulating polysaccharides from leaves of the Malian medicinal tree Combretum glutinosum; structural differences between small and large leaves can substantiate the preference for small leaves by some healers
J. Med. Plants Res., 5 (13), 2781-2790

Inngjerdingen KT, Meskini S, Austarheim I, Ballo N, Inngjerdingen M, Michaelsen TE, Diallo D, Paulsen BS (2011)
Chemical and biological characterization of polysaccharides from wild and cultivated roots of Vernonia kotschyana
J Ethnopharmacol, 139 (2), 350-8
DOI 10.1016/j.jep.2011.10.044, PubMed 22107838

Inngjerdingen M, Kveberg L, Naper C, Vaage JT (2011)
Natural killer cell subsets in man and rodents
Tissue Antigens, 78 (2), 81-8
DOI 10.1111/j.1399-0039.2011.01714.x, PubMed 21726202

Kveberg L, Dai KZ, Inngjerdingen M, Brooks CG, Fossum S, Vaage JT (2011)
Phylogenetic and functional conservation of the NKR-P1F and NKR-P1G receptors in rat and mouse
Immunogenetics, 63 (7), 429-36
DOI 10.1007/s00251-011-0520-1, PubMed 21409442

Naper C, Shegarfi H, Inngjerdingen M, Rolstad B (2011)
The role of natural killer cells in the defense against Listeria monocytogenes lessons from a rat model
J Innate Immun, 3 (3), 289-97
DOI 10.1159/000324143, PubMed 21430356

Publications 2010

Berge T, Sundvold-Gjerstad V, Granum S, Andersen TC, Holthe GB, Claesson-Welsh L, Andreotti AH, Inngjerdingen M, Spurkland A (2010)
T cell specific adapter protein (TSAd) interacts with Tec kinase ITK to promote CXCL12 induced migration of human and murine T cells
PLoS One, 5 (3), e9761
DOI 10.1371/journal.pone.0009761, PubMed 20305788

Grønhaug TE, Ghildyal P, Barsett H, Michaelsen TE, Morris G, Diallo D, Inngjerdingen M, Paulsen BS (2010)
Bioactive arabinogalactans from the leaves of Opilia celtidifolia Endl. ex Walp. (Opiliaceae)
Glycobiology, 20 (12), 1654-64
DOI 10.1093/glycob/cwq120, PubMed 20729344

Kveberg L, Jiménez-Royo P, Naper C, Rolstad B, Butcher GW, Vaage JT, Inngjerdingen M (2010)
Two complementary rat NK cell subsets, Ly49s3+ and NKR-P1B+, differ in phenotypic characteristics and responsiveness to cytokines
J Leukoc Biol, 88 (1), 87-93
DOI 10.1189/jlb.0110039, PubMed 20395458

Shegarfi H, Dai KZ, Inngjerdingen M, Ryan JC, Vaage JT, Rolstad B, Naper C (2010)
The activating rat Ly49s5 receptor responds to increased levels of MHC class Ib molecules on Listeria monocytogenes-infected enteric epithelial cells
Eur J Immunol, 40 (12), 3535-43
DOI 10.1002/eji.201040651, PubMed 21108473

Shegarfi H, Naper C, Rolstad B, Inngjerdingen M (2010)
Listeria monocytogenes infection affects a subset of Ly49-expressing NK cells in the rat
PLoS One, 5 (12), e15579
DOI 10.1371/journal.pone.0015579, PubMed 21179539

Publications 2009

Ngai J, Inngjerdingen M, Berge T, Taskén K (2009)
Interplay between the heterotrimeric G-protein subunits Galphaq and Galphai2 sets the threshold for chemotaxis and TCR activation
BMC Immunol, 10, 27
DOI 10.1186/1471-2172-10-27, PubMed 19426503

Shegarfi H, Sydnes K, Løvik M, Inngjerdingen M, Rolstad B, Naper C (2009)
The role of natural killer cells in resistance to the intracellular bacterium Listeria monocytogenes in rats
Scand J Immunol, 70 (3), 238-44
DOI 10.1111/j.1365-3083.2009.02292.x, PubMed 19703013

Publications 2008

Inngjerdingen M, Inngjerdingen KT, Patel TR, Allen S, Chen X, Rolstad B, Morris GA, Harding SE, Michaelsen TE, Diallo D, Paulsen BS (2008)
Pectic polysaccharides from Biophytum petersianum Klotzsch, and their activation of macrophages and dendritic cells
Glycobiology, 18 (12), 1074-84
DOI 10.1093/glycob/cwn090, PubMed 18809620

Publications 2007

Inngjerdingen KT, Kiyohara H, Matsumoto T, Petersen D, Michaelsen TE, Diallo D, Inngjerdingen M, Yamada H, Paulsen BS (2007)
An immunomodulating pectic polymer from Glinus oppositifolius
Phytochemistry, 68 (7), 1046-58
DOI 10.1016/j.phytochem.2007.01.011, PubMed 17337024

Inngjerdingen KT, Patel TR, Chen X, Kenne L, Allen S, Morris GA, Harding SE, Matsumoto T, Diallo D, Yamada H, Michaelsen TE, Inngjerdingen M, Paulsen BS (2007)
Immunological and structural properties of a pectic polymer from Glinus oppositifolius
Glycobiology, 17 (12), 1299-310
DOI 10.1093/glycob/cwm088, PubMed 17726087

Togola A, Inngjerdingen M, Diallo D, Barsett H, Rolstad B, Michaelsen TE, Paulsen BS (2007)
Polysaccharides with complement fixing and macrophage stimulation activity from Opilia celtidifolia, isolation and partial characterisation
J Ethnopharmacol, 115 (3), 423-31
DOI 10.1016/j.jep.2007.10.017, PubMed 18053663

Publications 2006

Kveberg L, Bäck CJ, Dai KZ, Inngjerdingen M, Rolstad B, Ryan JC, Vaage JT, Naper C (2006)
The novel inhibitory NKR-P1C receptor and Ly49s3 identify two complementary, functionally distinct NK cell subsets in rats
J Immunol, 176 (7), 4133-40
DOI 10.4049/jimmunol.176.7.4133, PubMed 16547249

Publications 2005

Bryceson YT, Torgersen KM, Inngjerdingen M, Berg SF, Hoelsbrekken SE, Fossum S, Dissen E (2005)
The rat orthologue to the inhibitory receptor gp49B is expressed by neutrophils and monocytes, but not by NK cells or mast cells
Eur J Immunol, 35 (4), 1230-9
DOI 10.1002/eji.200324593, PubMed 15756648

Inngjerdingen KT, Debes SC, Inngjerdingen M, Hokputsa S, Harding SE, Rolstad B, Michaelsen TE, Diallo D, Paulsen BS (2005)
Bioactive pectic polysaccharides from Glinus oppositifolius (L.) Aug. DC., a Malian medicinal plant, isolation and partial characterization
J Ethnopharmacol, 101 (1-3), 204-14
DOI 10.1016/j.jep.2005.04.021, PubMed 15996844

Kveberg L, Ryan JC, Rolstad B, Inngjerdingen M (2005)
Expression of regulator of G protein signalling proteins in natural killer cells, and their modulation by Ly49A and Ly49D
Immunology, 115 (3), 358-65
DOI 10.1111/j.1365-2567.2005.02174.x, PubMed 15946253

Nergard CS, Matsumoto T, Inngjerdingen M, Inngjerdingen K, Hokputsa S, Harding SE, Michaelsen TE, Diallo D, Kiyohara H, Paulsen BS, Yamada H (2005)
Structural and immunological studies of a pectin and a pectic arabinogalactan from Vernonia kotschyana Sch. Bip. ex Walp. (Asteraceae)
Carbohydr Res, 340 (1), 115-30
DOI 10.1016/j.carres.2004.10.023, PubMed 15620674

Publications 2003

Inngjerdingen M, Rolstad B, Ryan JC (2003)
Activating and inhibitory Ly49 receptors modulate NK cell chemotaxis to CXC chemokine ligand (CXCL) 10 and CXCL12
J Immunol, 171 (6), 2889-95
DOI 10.4049/jimmunol.171.6.2889, PubMed 12960311

Publications 2002

Inngjerdingen M, Torgersen KM, Maghazachi AA (2002)
Lck is required for stromal cell-derived factor 1 alpha (CXCL12)-induced lymphoid cell chemotaxis
Blood, 99 (12), 4318-25
DOI 10.1182/blood.v99.12.4318, PubMed 12036857

Kveberg L, Bryceson Y, Inngjerdingen M, Rolstad B, Maghazachi AA (2002)
Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases
Eur J Immunol, 32 (7), 1856-64
DOI 10.1002/1521-4141(200207)32:7<1856::AID-IMMU1856>3.0.CO;2-B, PubMed 12115604

Publications 2001

Inngjerdingen M, Damaj B, Maghazachi AA (2001)
Expression and regulation of chemokine receptors in human natural killer cells
Blood, 97 (2), 367-75
DOI 10.1182/blood.v97.2.367, PubMed 11154210

Publications 2000

Inngjerdingen M, Damaj B, Maghazachi AA (2000)
Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309
J Immunol, 164 (8), 4048-54
DOI 10.4049/jimmunol.164.8.4048, PubMed 10754297

Publications 1999

Inngjerdingen M, Al-Aoukaty A, Damaj B, Maghazachi AA (1999)
Differential utilization of cyclic ADP-ribose pathway by chemokines to induce the mobilization of intracellular calcium in NK cells
Biochem Biophys Res Commun, 262 (2), 467-72
DOI 10.1006/bbrc.1999.1234, PubMed 10462498

Inngjerdingen M, Waterhouse K, Solum NO (1999)
Studies on the dual effects on platelets of a monoclonal antibody to CD9, and on the properties of platelet CD9
Thromb Res, 95 (5), 215-27
DOI 10.1016/s0049-3848(99)00035-3, PubMed 10515286